ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	6.04378429
2	positive regulation of action potential (GO:0045760)	5.88891326
3	ribonucleoprotein complex disassembly (GO:0032988)	5.74575489
4	positive regulation of monocyte chemotaxis (GO:0090026)	5.56992184
5	tongue development (GO:0043586)	5.25686657
6	positive regulation of synaptic transmission, GABAergic (GO:0032230)	5.16334305
7	resolution of meiotic recombination intermediates (GO:0000712)	5.04725449
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.93933332
9	DNA strand renaturation (GO:0000733)	4.87971354
10	coenzyme catabolic process (GO:0009109)	4.73809851
11	pattern specification involved in kidney development (GO:0061004)	4.49925419
12	organelle disassembly (GO:1903008)	4.45952554
13	regulation of cilium movement (GO:0003352)	4.42603785
14	coenzyme A biosynthetic process (GO:0015937)	4.30659893
15	protein K11-linked deubiquitination (GO:0035871)	4.29343492
16	lens fiber cell development (GO:0070307)	4.27107440
17	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	4.20771060
18	ubiquinone biosynthetic process (GO:0006744)	4.05408079
19	DNA deamination (GO:0045006)	4.03623786
20	positive regulation of digestive system process (GO:0060456)	4.01428292
21	neuronal stem cell maintenance (GO:0097150)	3.98624241
22	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.96542757
23	pyrimidine nucleotide catabolic process (GO:0006244)	3.84374751
24	mitochondrion degradation (GO:0000422)	3.82593080
25	cytoplasmic sequestering of transcription factor (GO:0042994)	3.79719597
26	establishment of viral latency (GO:0019043)	3.78682518
27	cytidine deamination (GO:0009972)	3.76383810
28	cytidine metabolic process (GO:0046087)	3.76383810
29	cytidine catabolic process (GO:0006216)	3.76383810
30	negative regulation of heart rate (GO:0010459)	3.74098339
31	ubiquinone metabolic process (GO:0006743)	3.71961615
32	intestinal cholesterol absorption (GO:0030299)	3.70065086
33	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.67448500
34	UV protection (GO:0009650)	3.64749289
35	response to follicle-stimulating hormone (GO:0032354)	3.63236716
36	negative regulation of appetite (GO:0032099)	3.62256793
37	negative regulation of response to food (GO:0032096)	3.62256793
38	termination of RNA polymerase III transcription (GO:0006386)	3.52494787
39	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.52494787
40	positive regulation of protein kinase C signaling (GO:0090037)	3.46920853
41	regulation of monocyte chemotaxis (GO:0090025)	3.45584235
42	protein neddylation (GO:0045116)	3.44836283
43	regulation of action potential (GO:0098900)	3.43873198
44	negative regulation of telomere maintenance (GO:0032205)	3.42540710
45	xenobiotic catabolic process (GO:0042178)	3.38652578
46	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.37414644
47	regulation of protein kinase A signaling (GO:0010738)	3.36525414
48	positive regulation of protein homooligomerization (GO:0032464)	3.31318519
49	platelet dense granule organization (GO:0060155)	3.31160729
50	positive regulation of vascular permeability (GO:0043117)	3.29705673
51	regulation of glycogen (starch) synthase activity (GO:2000465)	3.28888100
52	establishment of mitochondrion localization (GO:0051654)	3.27384802
53	water-soluble vitamin biosynthetic process (GO:0042364)	3.24931573
54	male meiosis I (GO:0007141)	3.24824721
55	regulation of oxidative stress-induced neuron death (GO:1903203)	3.24659136
56	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.23860324
57	mitochondrion transport along microtubule (GO:0047497)	3.23860324
58	centrosome localization (GO:0051642)	3.23466980
59	regulation of microtubule-based movement (GO:0060632)	3.23427621
60	negative regulation of cAMP-mediated signaling (GO:0043951)	3.23289142
61	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.18562508
62	response to morphine (GO:0043278)	3.17528815
63	myoblast migration (GO:0051451)	3.16811688
64	metanephric nephron tubule development (GO:0072234)	3.16184284
65	metanephric tubule development (GO:0072170)	3.16184284
66	cerebral cortex radially oriented cell migration (GO:0021799)	3.14907068
67	acrosome reaction (GO:0007340)	3.14000444
68	quinone biosynthetic process (GO:1901663)	3.13329306
69	positive regulation of steroid hormone secretion (GO:2000833)	3.13124120
70	cellular response to glucose starvation (GO:0042149)	3.11302294
71	positive regulation of T cell apoptotic process (GO:0070234)	3.11207518
72	L-serine metabolic process (GO:0006563)	3.08133304
73	pantothenate metabolic process (GO:0015939)	3.07350216
74	cell differentiation involved in metanephros development (GO:0072202)	3.07071124
75	response to isoquinoline alkaloid (GO:0014072)	3.06729685
76	protein K6-linked ubiquitination (GO:0085020)	3.03815892
77	positive regulation of renal sodium excretion (GO:0035815)	3.03475302
78	positive regulation of defense response to virus by host (GO:0002230)	3.00992234
79	nucleoside diphosphate catabolic process (GO:0009134)	3.00638895
80	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.99728417
81	rRNA methylation (GO:0031167)	2.95667344
82	zinc ion homeostasis (GO:0055069)	2.93769595
83	polyamine biosynthetic process (GO:0006596)	2.91655143
84	replication fork processing (GO:0031297)	2.91070817
85	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.90543611
86	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.90543611
87	NADH dehydrogenase complex assembly (GO:0010257)	2.90543611
88	meiosis I (GO:0007127)	2.89274596
89	deoxyribonucleotide catabolic process (GO:0009264)	2.87452767
90	inner ear receptor cell differentiation (GO:0060113)	2.83555726
91	startle response (GO:0001964)	2.82843915
92	fat-soluble vitamin catabolic process (GO:0042363)	2.82150467
93	vitamin catabolic process (GO:0009111)	2.82150467
94	response to nitrosative stress (GO:0051409)	2.81486915
95	pyrimidine nucleoside catabolic process (GO:0046135)	2.81183671
96	somite development (GO:0061053)	2.80619444
97	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.80548101
98	mannosylation (GO:0097502)	2.78260207
99	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.78187476
100	melanin biosynthetic process (GO:0042438)	2.76909846

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.66250468
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.96934231
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.90052719
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.47800356
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.07624917
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.91428285
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.88156547
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.81195215
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.65303539
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.57484698
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.56709184
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.50809305
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.41653523
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.39000715
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.34605661
16	VDR_22108803_ChIP-Seq_LS180_Human	2.31821817
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30189901
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.23430052
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.21214297
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.20907686
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.01861520
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.94412159
23	CIITA_25753668_ChIP-Seq_RAJI_Human	1.92367665
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.87746722
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.81915725
26	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.77583299
27	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.77072907
28	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.76941493
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.74846319
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.74687076
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.73577641
32	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.68935622
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.66946446
34	ERA_21632823_ChIP-Seq_H3396_Human	1.66045977
35	ZNF274_21170338_ChIP-Seq_K562_Hela	1.65268168
36	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.64956032
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.63195922
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.62114713
39	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.61212035
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.52853211
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49872610
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.49613504
43	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.47859169
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.44655357
45	NCOR_22424771_ChIP-Seq_293T_Human	1.44324786
46	GABP_19822575_ChIP-Seq_HepG2_Human	1.43867888
47	TTF2_22483619_ChIP-Seq_HELA_Human	1.39192296
48	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.38989841
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30477030
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28793736
51	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.28203885
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.27954969
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.24653093
54	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24395968
55	EWS_26573619_Chip-Seq_HEK293_Human	1.22838270
56	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.20872600
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.20797119
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20797119
59	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.20721255
60	BCL6_27268052_Chip-Seq_Bcells_Human	1.19208367
61	XRN2_22483619_ChIP-Seq_HELA_Human	1.15782424
62	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15639831
63	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.15275558
64	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.13543930
65	FUS_26573619_Chip-Seq_HEK293_Human	1.10576055
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10385702
67	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.09786856
68	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.08647099
69	P53_21459846_ChIP-Seq_SAOS-2_Human	1.03192897
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03064117
71	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.02701227
72	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.01910080
73	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01867236
74	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.01203722
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00758832
76	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95961993
77	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.94247759
78	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.94174517
79	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.92833848
80	E2F1_20622854_ChIP-Seq_HELA_Human	0.92539653
81	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.90581129
82	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.89792732
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89356691
84	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.88575346
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.88567939
86	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.87914683
87	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.86878341
88	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.86859239
89	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.86026559
90	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.85983822
91	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.85743043
92	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.85650055
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84897186
94	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.84533515
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.84405434
96	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.82884278
97	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.82514750
98	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.82051047
99	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.81703609
100	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.81420599

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	9.30583366
2	MP0001529_abnormal_vocalization	4.66377247
3	MP0002102_abnormal_ear_morphology	3.22872785
4	MP0000566_synostosis	3.22521548
5	MP0001188_hyperpigmentation	2.76925329
6	MP0003329_amyloid_beta_deposits	2.75585428
7	MP0002089_abnormal_postnatal_growth/wei	2.66164266
8	MP0004142_abnormal_muscle_tone	2.44033352
9	MP0002653_abnormal_ependyma_morphology	2.43346156
10	MP0005409_darkened_coat_color	2.38952419
11	MP0001984_abnormal_olfaction	2.27165350
12	MP0000015_abnormal_ear_pigmentation	2.24258002
13	MP0010386_abnormal_urinary_bladder	2.21678113
14	MP0008789_abnormal_olfactory_epithelium	2.08326483
15	MP0005248_abnormal_Harderian_gland	1.99852001
16	MP0001486_abnormal_startle_reflex	1.98733411
17	MP0001968_abnormal_touch/_nociception	1.95994830
18	MP0002277_abnormal_respiratory_mucosa	1.94172337
19	MP0005394_taste/olfaction_phenotype	1.92633276
20	MP0005499_abnormal_olfactory_system	1.92633276
21	MP0003646_muscle_fatigue	1.84735659
22	MP0003186_abnormal_redox_activity	1.75379466
23	MP0001293_anophthalmia	1.62484440
24	MP0000604_amyloidosis	1.58932440
25	MP0008877_abnormal_DNA_methylation	1.57708770
26	MP0004924_abnormal_behavior	1.55631273
27	MP0005386_behavior/neurological_phenoty	1.55631273
28	MP0009780_abnormal_chondrocyte_physiolo	1.49800681
29	MP0001905_abnormal_dopamine_level	1.44352638
30	MP0006072_abnormal_retinal_apoptosis	1.44021577
31	MP0004133_heterotaxia	1.43671595
32	MP0002249_abnormal_larynx_morphology	1.43097424
33	MP0006035_abnormal_mitochondrial_morpho	1.35296418
34	MP0002736_abnormal_nociception_after	1.32710852
35	MP0001346_abnormal_lacrimal_gland	1.29946478
36	MP0002095_abnormal_skin_pigmentation	1.29120955
37	MP0001666_abnormal_nutrient_absorption	1.28584375
38	MP0008872_abnormal_physiological_respon	1.26097890
39	MP0001485_abnormal_pinna_reflex	1.25922980
40	MP0008875_abnormal_xenobiotic_pharmacok	1.25698838
41	MP0009745_abnormal_behavioral_response	1.25685671
42	MP0000358_abnormal_cell_content/	1.22883327
43	MP0001970_abnormal_pain_threshold	1.22569011
44	MP0009384_cardiac_valve_regurgitation	1.19945439
45	MP0003252_abnormal_bile_duct	1.18191362
46	MP0003123_paternal_imprinting	1.12700997
47	MP0000631_abnormal_neuroendocrine_gland	1.10476831
48	MP0002734_abnormal_mechanical_nocicepti	1.10090787
49	MP0000371_diluted_coat_color	1.06354242
50	MP0001986_abnormal_taste_sensitivity	1.06237374
51	MP0005085_abnormal_gallbladder_physiolo	1.05857853
52	MP0004381_abnormal_hair_follicle	1.05412589
53	MP0010030_abnormal_orbit_morphology	1.05317729
54	MP0000778_abnormal_nervous_system	1.04313990
55	MP0003787_abnormal_imprinting	1.02854387
56	MP0002272_abnormal_nervous_system	1.01243857
57	MP0000026_abnormal_inner_ear	1.00908580
58	MP0002572_abnormal_emotion/affect_behav	0.98466343
59	MP0002557_abnormal_social/conspecific_i	0.97331613
60	MP0009250_abnormal_appendicular_skeleto	0.96585253
61	MP0001963_abnormal_hearing_physiology	0.95529881
62	MP0005174_abnormal_tail_pigmentation	0.94927059
63	MP0005464_abnormal_platelet_physiology	0.90039197
64	MP0005671_abnormal_response_to	0.85636782
65	MP0003632_abnormal_nervous_system	0.85083170
66	MP0006292_abnormal_olfactory_placode	0.85081022
67	MP0009697_abnormal_copulation	0.84251330
68	MP0002075_abnormal_coat/hair_pigmentati	0.81577660
69	MP0003698_abnormal_male_reproductive	0.81378890
70	MP0004145_abnormal_muscle_electrophysio	0.81005888
71	MP0000465_gastrointestinal_hemorrhage	0.80051357
72	MP0005645_abnormal_hypothalamus_physiol	0.79256767
73	MP0001929_abnormal_gametogenesis	0.78485942
74	MP0003121_genomic_imprinting	0.75974697
75	MP0002064_seizures	0.75923929
76	MP0001440_abnormal_grooming_behavior	0.74387578
77	MP0002063_abnormal_learning/memory/cond	0.73772518
78	MP0004885_abnormal_endolymph	0.72479365
79	MP0000955_abnormal_spinal_cord	0.72174677
80	MP0005410_abnormal_fertilization	0.72125354
81	MP0002733_abnormal_thermal_nociception	0.71753631
82	MP0000049_abnormal_middle_ear	0.71042092
83	MP0001186_pigmentation_phenotype	0.68917900
84	MP0002837_dystrophic_cardiac_calcinosis	0.66362330
85	MP0002882_abnormal_neuron_morphology	0.66032579
86	MP0001765_abnormal_ion_homeostasis	0.62229434
87	MP0002735_abnormal_chemical_nociception	0.60405413
88	MP0005423_abnormal_somatic_nervous	0.59428570
89	MP0005253_abnormal_eye_physiology	0.59280365
90	MP0005195_abnormal_posterior_eye	0.59220966
91	MP0003635_abnormal_synaptic_transmissio	0.58708717
92	MP0002184_abnormal_innervation	0.55959356
93	MP0002938_white_spotting	0.54732547
94	MP0005075_abnormal_melanosome_morpholog	0.54218297
95	MP0005332_abnormal_amino_acid	0.53961751
96	MP0002282_abnormal_trachea_morphology	0.53046821
97	MP0003221_abnormal_cardiomyocyte_apopto	0.52774696
98	MP0002752_abnormal_somatic_nervous	0.52122230
99	MP0002210_abnormal_sex_determination	0.51947395
100	MP0002066_abnormal_motor_capabilities/c	0.51908981

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.84515392
2	Cortical dysplasia (HP:0002539)	4.22809582
3	Type II lissencephaly (HP:0007260)	4.20227054
4	Thickened helices (HP:0000391)	4.01940235
5	Rib fusion (HP:0000902)	3.76724723
6	CNS hypomyelination (HP:0003429)	3.74449573
7	Hypoplasia of the capital femoral epiphysis (HP:0003090)	3.71956496
8	Abnormality of the aortic arch (HP:0012303)	3.71112773
9	Abnormality of the pons (HP:0007361)	3.68064822
10	Hypoplasia of the pons (HP:0012110)	3.59602829
11	Medial flaring of the eyebrow (HP:0010747)	3.49133748
12	Septo-optic dysplasia (HP:0100842)	3.47681541
13	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	3.42988850
14	Absent epiphyses (HP:0010577)	3.42988850
15	Esophageal atresia (HP:0002032)	3.35565889
16	Renal dysplasia (HP:0000110)	3.31258270
17	Lipid accumulation in hepatocytes (HP:0006561)	3.28635435
18	Abnormal rod and cone electroretinograms (HP:0008323)	3.22068527
19	Tongue fasciculations (HP:0001308)	3.20336643
20	Cerebellar dysplasia (HP:0007033)	3.17362761
21	Congenital primary aphakia (HP:0007707)	3.13798367
22	Gait imbalance (HP:0002141)	3.11542599
23	Retinal dysplasia (HP:0007973)	3.10377071
24	Increased hepatocellular lipid droplets (HP:0006565)	3.03737092
25	Gastrointestinal atresia (HP:0002589)	2.89936721
26	High pitched voice (HP:0001620)	2.89354503
27	Large for gestational age (HP:0001520)	2.89319615
28	Long foot (HP:0001833)	2.88245306
29	Pancreatic islet-cell hyperplasia (HP:0004510)	2.84428642
30	Renal Fanconi syndrome (HP:0001994)	2.81336880
31	Poor coordination (HP:0002370)	2.75461814
32	Poor eye contact (HP:0000817)	2.72470812
33	Increased CSF lactate (HP:0002490)	2.69255045
34	Specific learning disability (HP:0001328)	2.68583934
35	Polyphagia (HP:0002591)	2.66725134
36	Severe muscular hypotonia (HP:0006829)	2.65949317
37	Muscle fibrillation (HP:0010546)	2.64189868
38	Atonic seizures (HP:0010819)	2.60794839
39	Nephronophthisis (HP:0000090)	2.60730681
40	Vitreoretinal degeneration (HP:0000655)	2.55014597
41	Nephrogenic diabetes insipidus (HP:0009806)	2.52634275
42	Abnormality of the renal medulla (HP:0100957)	2.52071386
43	Increased intramyocellular lipid droplets (HP:0012240)	2.51086333
44	Abnormality of midbrain morphology (HP:0002418)	2.44718095
45	Molar tooth sign on MRI (HP:0002419)	2.44718095
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.44573741
47	Abolished electroretinogram (ERG) (HP:0000550)	2.44047094
48	Optic nerve hypoplasia (HP:0000609)	2.43033789
49	Abnormality of the metopic suture (HP:0005556)	2.42132521
50	True hermaphroditism (HP:0010459)	2.39151348
51	Abnormal drinking behavior (HP:0030082)	2.37068638
52	Polydipsia (HP:0001959)	2.37068638
53	Increased muscle lipid content (HP:0009058)	2.36360985
54	Volvulus (HP:0002580)	2.34559447
55	Bell-shaped thorax (HP:0001591)	2.31085959
56	Hepatocellular necrosis (HP:0001404)	2.31003264
57	Dyschromatopsia (HP:0007641)	2.29453751
58	Pancreatic cysts (HP:0001737)	2.27688995
59	Cortical visual impairment (HP:0100704)	2.27113134
60	Thyroid-stimulating hormone excess (HP:0002925)	2.26742124
61	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.25740078
62	Acute necrotizing encephalopathy (HP:0006965)	2.24797101
63	Hypsarrhythmia (HP:0002521)	2.23882117
64	Vertebral arch anomaly (HP:0008438)	2.23745316
65	Abnormality of the renal cortex (HP:0011035)	2.23598834
66	Vertebral clefting (HP:0008428)	2.23233754
67	Abnormality of the pancreatic islet cells (HP:0006476)	2.22427632
68	Abnormality of endocrine pancreas physiology (HP:0012093)	2.22427632
69	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.22415863
70	Upper limb muscle weakness (HP:0003484)	2.18518989
71	Postaxial foot polydactyly (HP:0001830)	2.15885724
72	Chronic hepatic failure (HP:0100626)	2.13348049
73	Missing ribs (HP:0000921)	2.12432353
74	Abnormality of DNA repair (HP:0003254)	2.11716853
75	Colon cancer (HP:0003003)	2.10832833
76	Lissencephaly (HP:0001339)	2.09396128
77	Vaginal atresia (HP:0000148)	2.08408262
78	Mitochondrial inheritance (HP:0001427)	2.08002457
79	EEG with generalized epileptiform discharges (HP:0011198)	2.07974313
80	Absent septum pellucidum (HP:0001331)	2.07948286
81	Spastic diplegia (HP:0001264)	2.05364278
82	Short femoral neck (HP:0100864)	2.04014669
83	Abnormal mitochondria in muscle tissue (HP:0008316)	2.03745456
84	Exertional dyspnea (HP:0002875)	2.02666355
85	Epileptiform EEG discharges (HP:0011182)	2.00286933
86	Prominent metopic ridge (HP:0005487)	1.97387765
87	Abnormality of glycine metabolism (HP:0010895)	1.95759258
88	Abnormality of serine family amino acid metabolism (HP:0010894)	1.95759258
89	Genital tract atresia (HP:0001827)	1.95034711
90	Abnormal social behavior (HP:0012433)	1.94572290
91	Impaired social interactions (HP:0000735)	1.94572290
92	Maternal diabetes (HP:0009800)	1.93603517
93	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.93340758
94	Hepatic necrosis (HP:0002605)	1.92411221
95	Abnormality of renal resorption (HP:0011038)	1.89284507
96	Pancreatic fibrosis (HP:0100732)	1.88881280
97	11 pairs of ribs (HP:0000878)	1.88542270
98	Abnormal biliary tract physiology (HP:0012439)	1.88492886
99	Bile duct proliferation (HP:0001408)	1.88492886
100	Ketosis (HP:0001946)	1.88418019

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.46387813
2	WNK4	4.00862271
3	BRAF	3.58237272
4	STK16	3.36278160
5	STK39	2.97260689
6	BCKDK	2.95563161
7	TNIK	2.89949335
8	MAP2K7	2.87473253
9	MAP2K2	2.61836628
10	PAK6	2.32891225
11	LIMK1	2.25443432
12	VRK1	2.17937117
13	TLK1	2.08866953
14	MAPK13	1.68475255
15	TXK	1.63850736
16	VRK2	1.61672016
17	EPHB2	1.58210936
18	KDR	1.57219433
19	MAPK15	1.54889006
20	NLK	1.54828751
21	WNK1	1.43606898
22	EIF2AK3	1.41363002
23	CDK19	1.37865459
24	PBK	1.32071229
25	TESK2	1.29441830
26	PRKCQ	1.28739643
27	MAPKAPK3	1.26152842
28	MAP3K4	1.25958635
29	MOS	1.25943998
30	DAPK3	1.23939755
31	TEC	1.22985046
32	TAOK1	1.21178886
33	AURKA	1.18703652
34	GRK1	1.17838945
35	ZAK	1.16699635
36	PRKD3	1.15462069
37	PKN1	1.13823286
38	EPHA4	1.04285996
39	BCR	0.98942797
40	AKT2	0.95753739
41	TESK1	0.94681646
42	KSR2	0.77530289
43	PRKCG	0.77285714
44	FRK	0.77271637
45	CAMK1D	0.77040056
46	CSNK1G3	0.75779136
47	DAPK1	0.75094210
48	DYRK2	0.72706879
49	PRKD2	0.72455080
50	TAOK3	0.71177584
51	ROCK1	0.70128741
52	NUAK1	0.68569881
53	MAPKAPK5	0.67308610
54	EIF2AK1	0.66673006
55	MAP2K6	0.65937343
56	PRKCE	0.64331392
57	PAK3	0.62907711
58	BTK	0.62345991
59	CSNK1G2	0.61894247
60	CSNK1G1	0.61278515
61	ERBB2	0.59039168
62	PRKCH	0.58608240
63	CDK12	0.57434439
64	ERBB3	0.57230115
65	CDC7	0.55173302
66	PRKCD	0.53382966
67	EEF2K	0.52962485
68	RPS6KA2	0.49947145
69	CDK5	0.49481661
70	SYK	0.47567338
71	CAMK1G	0.47419093
72	EIF2AK2	0.46775799
73	ATR	0.46761847
74	CSNK1A1L	0.46732486
75	MAP3K8	0.46043136
76	INSRR	0.43968039
77	DDR2	0.42118745
78	NTRK2	0.40784221
79	CAMKK2	0.40645051
80	PLK2	0.40626740
81	MARK2	0.40528671
82	CHEK1	0.39101634
83	PLK1	0.38407212
84	GRK7	0.36132539
85	PRKAA2	0.36004517
86	PRKCZ	0.35837179
87	STK11	0.35531219
88	CAMK2A	0.34955141
89	CDK14	0.34141376
90	PDK1	0.32997866
91	RPS6KA5	0.32473799
92	TRIM28	0.32135700
93	CAMK2D	0.31745593
94	ADRBK2	0.30723288
95	MAPK9	0.30620229
96	PRKCA	0.30555743
97	CDK15	0.30425420
98	SGK223	0.30287772
99	SGK494	0.30287772
100	CDK11A	0.29733856

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	5.02514221
2	Steroid biosynthesis_Homo sapiens_hsa00100	3.50258107
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.94258357
4	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.78365768
5	RNA polymerase_Homo sapiens_hsa03020	2.74645116
6	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.71668174
7	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.50846134
8	Parkinsons disease_Homo sapiens_hsa05012	2.35752741
9	Ribosome_Homo sapiens_hsa03010	2.20733920
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.15863845
11	Huntingtons disease_Homo sapiens_hsa05016	2.00848283
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.92363481
13	Insulin secretion_Homo sapiens_hsa04911	1.88912132
14	Glutathione metabolism_Homo sapiens_hsa00480	1.76688067
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.73633099
16	Peroxisome_Homo sapiens_hsa04146	1.69629171
17	Alcoholism_Homo sapiens_hsa05034	1.55958669
18	Sulfur metabolism_Homo sapiens_hsa00920	1.55933984
19	Proteasome_Homo sapiens_hsa03050	1.51683155
20	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.50266355
21	Arginine and proline metabolism_Homo sapiens_hsa00330	1.49971620
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.46014110
23	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.43406600
24	Cocaine addiction_Homo sapiens_hsa05030	1.41436294
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.35879684
26	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.33658063
27	ABC transporters_Homo sapiens_hsa02010	1.32162677
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.31013992
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30524037
30	Primary immunodeficiency_Homo sapiens_hsa05340	1.28179762
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27827972
32	Propanoate metabolism_Homo sapiens_hsa00640	1.26718725
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25249574
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.23676093
35	Mismatch repair_Homo sapiens_hsa03430	1.19340625
36	Alzheimers disease_Homo sapiens_hsa05010	1.17226068
37	Melanogenesis_Homo sapiens_hsa04916	1.16466596
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13045682
39	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.07311585
40	Taste transduction_Homo sapiens_hsa04742	1.06271375
41	Dopaminergic synapse_Homo sapiens_hsa04728	0.95815077
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.94775979
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93245432
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92181298
45	Hippo signaling pathway_Homo sapiens_hsa04390	0.92147924
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.91417104
47	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.90768408
48	Protein export_Homo sapiens_hsa03060	0.89331164
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89199044
50	Basal transcription factors_Homo sapiens_hsa03022	0.87018863
51	Nicotine addiction_Homo sapiens_hsa05033	0.86684927
52	Amphetamine addiction_Homo sapiens_hsa05031	0.85489685
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.83166040
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.79015656
55	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.78905193
56	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.78491840
57	cAMP signaling pathway_Homo sapiens_hsa04024	0.78417989
58	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.78012777
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76376344
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73015639
61	Thyroid cancer_Homo sapiens_hsa05216	0.70135426
62	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.69016808
63	Phototransduction_Homo sapiens_hsa04744	0.68230049
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.67071233
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.65995334
66	mRNA surveillance pathway_Homo sapiens_hsa03015	0.65863396
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65776901
68	Glucagon signaling pathway_Homo sapiens_hsa04922	0.64489944
69	Bladder cancer_Homo sapiens_hsa05219	0.63440392
70	Spliceosome_Homo sapiens_hsa03040	0.63231281
71	Selenocompound metabolism_Homo sapiens_hsa00450	0.62679268
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.61385739
73	Bile secretion_Homo sapiens_hsa04976	0.59587132
74	Purine metabolism_Homo sapiens_hsa00230	0.58912282
75	Carbon metabolism_Homo sapiens_hsa01200	0.55585499
76	Ether lipid metabolism_Homo sapiens_hsa00565	0.55230788
77	AMPK signaling pathway_Homo sapiens_hsa04152	0.51069304
78	Prion diseases_Homo sapiens_hsa05020	0.50325082
79	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.47689559
80	Metabolic pathways_Homo sapiens_hsa01100	0.47359075
81	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.45396425
82	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.44236938
83	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.44006311
84	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.40588375
85	Fatty acid degradation_Homo sapiens_hsa00071	0.39742592
86	Lysine degradation_Homo sapiens_hsa00310	0.37590722
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36853228
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36011191
89	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.35502055
90	Butanoate metabolism_Homo sapiens_hsa00650	0.34740309
91	Regulation of autophagy_Homo sapiens_hsa04140	0.34223610
92	Wnt signaling pathway_Homo sapiens_hsa04310	0.33824529
93	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32695122
94	Apoptosis_Homo sapiens_hsa04210	0.31924199
95	Viral carcinogenesis_Homo sapiens_hsa05203	0.31880492
96	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.31494898
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.31293576
98	RNA degradation_Homo sapiens_hsa03018	0.29386333
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28630536
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.27951664

GCOM2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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