GCSAML

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein thought to be a signaling molecule associated with germinal centers, the sites of proliferation and differentiation of mature B lymphocytes. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)6.86325150
2definitive hemopoiesis (GO:0060216)5.48596015
3positive regulation of granulocyte differentiation (GO:0030854)4.61698180
4megakaryocyte development (GO:0035855)4.32830435
5positive regulation of vasculogenesis (GO:2001214)3.99098807
6positive regulation of B cell differentiation (GO:0045579)3.98051230
7piRNA metabolic process (GO:0034587)3.77237000
8regulation of memory T cell differentiation (GO:0043380)3.74216031
9negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.49788072
10negative regulation of T-helper cell differentiation (GO:0045623)3.49788072
11regulation of platelet aggregation (GO:0090330)3.46117245
12neutrophil activation involved in immune response (GO:0002283)3.44185027
13protein neddylation (GO:0045116)3.42217889
14negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.41540858
15aggressive behavior (GO:0002118)3.40112399
16regulation of B cell receptor signaling pathway (GO:0050855)3.39826830
17purinergic nucleotide receptor signaling pathway (GO:0035590)3.37257032
18indolalkylamine metabolic process (GO:0006586)3.33521355
19neural tube formation (GO:0001841)3.32044743
20tryptophan metabolic process (GO:0006568)3.23228509
21regulation of platelet activation (GO:0010543)3.22178095
22phosphatidylinositol acyl-chain remodeling (GO:0036149)3.10727274
23platelet dense granule organization (GO:0060155)3.06232465
24nerve growth factor signaling pathway (GO:0038180)3.06103092
25positive regulation of gamma-delta T cell activation (GO:0046645)3.04184572
26negative regulation of thymocyte apoptotic process (GO:0070244)3.03372662
27negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96404366
28embryonic hemopoiesis (GO:0035162)2.94611903
29regulation of erythrocyte differentiation (GO:0045646)2.94065024
30endothelium development (GO:0003158)2.93722411
31negative regulation of neurotransmitter transport (GO:0051589)2.90904979
32response to pheromone (GO:0019236)2.88457850
33regulation of granulocyte differentiation (GO:0030852)2.85110820
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83224418
35autophagic vacuole fusion (GO:0000046)2.76782977
36regulation of regulatory T cell differentiation (GO:0045589)2.74873215
37positive regulation of steroid hormone secretion (GO:2000833)2.72752937
38regulation of vasculogenesis (GO:2001212)2.72273891
39organelle membrane fusion (GO:0090174)2.71654510
40regulation of T-helper 1 cell differentiation (GO:0045625)2.71338334
41positive regulation of alpha-beta T cell proliferation (GO:0046641)2.71310896
42myeloid cell development (GO:0061515)2.70895380
43tryptophan catabolic process (GO:0006569)2.69391679
44indole-containing compound catabolic process (GO:0042436)2.69391679
45indolalkylamine catabolic process (GO:0046218)2.69391679
46dopamine transport (GO:0015872)2.69038303
47adenosine metabolic process (GO:0046085)2.68271145
48interkinetic nuclear migration (GO:0022027)2.67741131
49tachykinin receptor signaling pathway (GO:0007217)2.67449885
50parental behavior (GO:0060746)2.67440844
51protein K11-linked deubiquitination (GO:0035871)2.65393860
52phosphatidylserine acyl-chain remodeling (GO:0036150)2.64042384
53fucose catabolic process (GO:0019317)2.63341547
54L-fucose metabolic process (GO:0042354)2.63341547
55L-fucose catabolic process (GO:0042355)2.63341547
56monoamine transport (GO:0015844)2.63218577
57ether lipid metabolic process (GO:0046485)2.61256779
58histamine secretion (GO:0001821)2.59190665
59regulation of gamma-delta T cell differentiation (GO:0045586)2.58727169
60angiogenesis involved in wound healing (GO:0060055)2.56745606
61cellular biogenic amine catabolic process (GO:0042402)2.56587803
62amine catabolic process (GO:0009310)2.56587803
63cellular response to ethanol (GO:0071361)2.56141098
64B cell receptor signaling pathway (GO:0050853)2.54058358
65negative regulation of calcium ion transport into cytosol (GO:0010523)2.53843215
66neutrophil activation (GO:0042119)2.53153879
67positive regulation of T-helper cell differentiation (GO:0045624)2.52012858
68tyrosine phosphorylation of STAT protein (GO:0007260)2.51913074
69heparin biosynthetic process (GO:0030210)2.51857101
70heparin metabolic process (GO:0030202)2.51857101
71negative regulation of alpha-beta T cell differentiation (GO:0046639)2.50695829
72regulation of B cell differentiation (GO:0045577)2.50093714
73positive regulation of histone H3-K4 methylation (GO:0051571)2.49486445
74positive regulation of cAMP-mediated signaling (GO:0043950)2.47883085
75positive regulation of mast cell activation (GO:0033005)2.47722874
76detection of light stimulus involved in sensory perception (GO:0050962)2.47599172
77detection of light stimulus involved in visual perception (GO:0050908)2.47599172
78mast cell degranulation (GO:0043303)2.46972247
79mast cell activation involved in immune response (GO:0002279)2.46972247
80positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.46731275
81cell wall macromolecule catabolic process (GO:0016998)2.46124261
82cardiolipin metabolic process (GO:0032048)2.45929314
83DNA double-strand break processing (GO:0000729)2.45865433
84regulation of establishment of cell polarity (GO:2000114)2.44016550
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43882576
86replication fork processing (GO:0031297)2.42848336
87positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.42716382
88positive regulation of erythrocyte differentiation (GO:0045648)2.42223734
89photoreceptor cell maintenance (GO:0045494)2.42019343
90regulation of inositol phosphate biosynthetic process (GO:0010919)2.41056637
91negative regulation of erythrocyte differentiation (GO:0045647)2.40977929
92mast cell activation (GO:0045576)2.39906836
93regulation of B cell apoptotic process (GO:0002902)2.39403926
94regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.39221946
95seminiferous tubule development (GO:0072520)2.37608198
96regulation of mast cell activation (GO:0033003)2.36817292
97regulation of meiosis I (GO:0060631)2.36270990
98positive regulation of prostaglandin secretion (GO:0032308)2.35188809
99DNA deamination (GO:0045006)2.35116663
100G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.34502677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human3.36598392
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.95459799
3IGF1R_20145208_ChIP-Seq_DFB_Human2.80220128
4VDR_22108803_ChIP-Seq_LS180_Human2.70889463
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63206472
6ZNF274_21170338_ChIP-Seq_K562_Hela2.60287555
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48136275
8GBX2_23144817_ChIP-Seq_PC3_Human2.40279342
9GATA1_22025678_ChIP-Seq_K562_Human2.30220737
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.23705449
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.09242785
12EWS_26573619_Chip-Seq_HEK293_Human2.04128095
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02819772
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97605136
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96822010
16FUS_26573619_Chip-Seq_HEK293_Human1.89777762
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.89208127
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86956517
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86872435
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.84042300
21ER_23166858_ChIP-Seq_MCF-7_Human1.80200041
22GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.75243111
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75057356
24SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.72326131
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71687726
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71236835
27TAF15_26573619_Chip-Seq_HEK293_Human1.68281497
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66041886
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64904657
30P300_19829295_ChIP-Seq_ESCs_Human1.64157912
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52298883
32GATA3_26560356_Chip-Seq_TH2_Human1.51639571
33MYB_26560356_Chip-Seq_TH2_Human1.51094300
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48574565
35CBP_20019798_ChIP-Seq_JUKART_Human1.47314404
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47314404
37RUNX_20019798_ChIP-Seq_JUKART_Human1.41739978
38IRF1_19129219_ChIP-ChIP_H3396_Human1.41005165
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40236732
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39822799
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39402236
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.38155526
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38120792
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36439262
45SMAD4_21799915_ChIP-Seq_A2780_Human1.35995748
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35405449
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.34068145
48STAT3_23295773_ChIP-Seq_U87_Human1.33683631
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.31406314
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30336346
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.28765987
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26431096
53NANOG_19829295_ChIP-Seq_ESCs_Human1.25499658
54SOX2_19829295_ChIP-Seq_ESCs_Human1.25499658
55TCF4_23295773_ChIP-Seq_U87_Human1.25447934
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.24939815
57GATA3_27048872_Chip-Seq_THYMUS_Human1.24331346
58HTT_18923047_ChIP-ChIP_STHdh_Human1.23037829
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21431504
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21346999
61AR_25329375_ChIP-Seq_VCAP_Human1.19091374
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18937138
63ELK1_19687146_ChIP-ChIP_HELA_Human1.18773526
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18709072
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18181242
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.17545512
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17088712
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16281652
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16260790
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.15274397
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15082230
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14326086
73CDX2_22108803_ChIP-Seq_LS180_Human1.14305811
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14098370
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.13036769
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12711405
77TP53_22573176_ChIP-Seq_HFKS_Human1.12448186
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.11636075
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10193291
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10161728
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.10152052
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10152052
83SALL4_22934838_ChIP-ChIP_CD34+_Human1.10099917
84BCAT_22108803_ChIP-Seq_LS180_Human1.09721768
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.09518077
86VDR_23849224_ChIP-Seq_CD4+_Human1.09408590
87SPI1_23547873_ChIP-Seq_NB4_Human1.09390353
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09315409
89GATA1_19941826_ChIP-Seq_K562_Human1.09098256
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08837897
91GATA2_19941826_ChIP-Seq_K562_Human1.08334085
92OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07246377
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07191993
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.06874029
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.06400974
96P53_22387025_ChIP-Seq_ESCs_Mouse1.06358210
97VDR_24787735_ChIP-Seq_THP-1_Human1.04867012
98AR_20517297_ChIP-Seq_VCAP_Human1.04705354
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.03462680
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01553106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.15043477
2MP0003724_increased_susceptibility_to2.79035155
3MP0005646_abnormal_pituitary_gland2.76573307
4MP0000465_gastrointestinal_hemorrhage2.55801040
5MP0002396_abnormal_hematopoietic_system2.34595518
6MP0001835_abnormal_antigen_presentation2.14376866
7MP0004147_increased_porphyrin_level2.12082773
8MP0001968_abnormal_touch/_nociception2.11605993
9MP0001545_abnormal_hematopoietic_system2.08710818
10MP0005397_hematopoietic_system_phenotyp2.08710818
11MP0005174_abnormal_tail_pigmentation2.02018719
12MP0004808_abnormal_hematopoietic_stem1.96329388
13MP0002148_abnormal_hypersensitivity_rea1.93216075
14MP0005084_abnormal_gallbladder_morpholo1.90985754
15MP0002736_abnormal_nociception_after1.87560804
16MP0008057_abnormal_DNA_replication1.80653143
17MP0000372_irregular_coat_pigmentation1.77058293
18MP0000015_abnormal_ear_pigmentation1.70960195
19MP0005075_abnormal_melanosome_morpholog1.69111228
20MP0003303_peritoneal_inflammation1.67731165
21MP0009697_abnormal_copulation1.62143468
22MP0000569_abnormal_digit_pigmentation1.60535791
23MP0008058_abnormal_DNA_repair1.58655094
24MP0004084_abnormal_cardiac_muscle1.57624601
25MP0008877_abnormal_DNA_methylation1.55413640
26MP0000230_abnormal_systemic_arterial1.55255528
27MP0008872_abnormal_physiological_respon1.49439239
28MP0002398_abnormal_bone_marrow1.48606588
29MP0008004_abnormal_stomach_pH1.46075475
30MP0001800_abnormal_humoral_immune1.43629323
31MP0005410_abnormal_fertilization1.39255845
32MP0002102_abnormal_ear_morphology1.37036951
33MP0000689_abnormal_spleen_morphology1.34724393
34MP0002138_abnormal_hepatobiliary_system1.33971492
35MP0003763_abnormal_thymus_physiology1.33626858
36MP0005000_abnormal_immune_tolerance1.32693773
37MP0002723_abnormal_immune_serum1.31551987
38MP0005167_abnormal_blood-brain_barrier1.30117632
39MP0002837_dystrophic_cardiac_calcinosis1.29782422
40MP0006054_spinal_hemorrhage1.28455623
41MP0003183_abnormal_peptide_metabolism1.27979096
42MP0009764_decreased_sensitivity_to1.27025394
43MP0003656_abnormal_erythrocyte_physiolo1.25400586
44MP0005551_abnormal_eye_electrophysiolog1.24897463
45MP0008775_abnormal_heart_ventricle1.24166825
46MP0003718_maternal_effect1.23694346
47MP0005671_abnormal_response_to1.23595438
48MP0002420_abnormal_adaptive_immunity1.22590391
49MP0002452_abnormal_antigen_presenting1.20974455
50MP0001819_abnormal_immune_cell1.20603177
51MP0001764_abnormal_homeostasis1.18680878
52MP0006276_abnormal_autonomic_nervous1.16135262
53MP0003787_abnormal_imprinting1.15852884
54MP0002095_abnormal_skin_pigmentation1.13666460
55MP0002722_abnormal_immune_system1.12425642
56MP0001986_abnormal_taste_sensitivity1.11705444
57MP0000383_abnormal_hair_follicle1.11216757
58MP0003866_abnormal_defecation1.10015444
59MP0000716_abnormal_immune_system1.09086164
60MP0010386_abnormal_urinary_bladder1.08389774
61MP0003195_calcinosis1.06823673
62MP0009278_abnormal_bone_marrow1.05079649
63MP0004484_altered_response_of1.03132612
64MP0002429_abnormal_blood_cell1.02846008
65MP0002132_abnormal_respiratory_system1.02194999
66MP0002419_abnormal_innate_immunity0.99704127
67MP0001501_abnormal_sleep_pattern0.98970101
68MP0005310_abnormal_salivary_gland0.98497564
69MP0005083_abnormal_biliary_tract0.97923577
70MP0005535_abnormal_body_temperature0.97371900
71MP0010155_abnormal_intestine_physiology0.97206695
72MP0000343_altered_response_to0.91320485
73MP0005387_immune_system_phenotype0.90774667
74MP0001790_abnormal_immune_system0.90774667
75MP0005645_abnormal_hypothalamus_physiol0.90643394
76MP0002735_abnormal_chemical_nociception0.90503494
77MP0004036_abnormal_muscle_relaxation0.89599164
78MP0000516_abnormal_urinary_system0.88986374
79MP0005367_renal/urinary_system_phenotyp0.88986374
80MP0009765_abnormal_xenobiotic_induced0.87014079
81MP0000703_abnormal_thymus_morphology0.86887556
82MP0003252_abnormal_bile_duct0.86704263
83MP0003943_abnormal_hepatobiliary_system0.85769963
84MP0005025_abnormal_response_to0.84557077
85MP0006036_abnormal_mitochondrial_physio0.81797755
86MP0001851_eye_inflammation0.81501612
87MP0003806_abnormal_nucleotide_metabolis0.80400570
88MP0001664_abnormal_digestion0.79981797
89MP0002733_abnormal_thermal_nociception0.79957799
90MP0001845_abnormal_inflammatory_respons0.79541634
91MP0005670_abnormal_white_adipose0.76934586
92MP0002405_respiratory_system_inflammati0.75648842
93MP0009785_altered_susceptibility_to0.74575742
94MP0004215_abnormal_myocardial_fiber0.72110391
95MP0003172_abnormal_lysosome_physiology0.71402824
96MP0003880_abnormal_central_pattern0.71295280
97MP0003638_abnormal_response/metabolism_0.70580718
98MP0009763_increased_sensitivity_to0.70510161
99MP0003828_pulmonary_edema0.69818440
100MP0002019_abnormal_tumor_incidence0.69734952

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.40256425
2Petechiae (HP:0000967)5.00658680
3Increased mean platelet volume (HP:0011877)4.05230412
4Epistaxis (HP:0000421)3.99194140
5Abnormal platelet volume (HP:0011876)3.84094891
6Menorrhagia (HP:0000132)3.67614207
7Stomatitis (HP:0010280)3.50744073
8Panhypogammaglobulinemia (HP:0003139)3.49241166
9Gingival bleeding (HP:0000225)3.41679119
10Dyschromatopsia (HP:0007641)3.33521535
11Acute lymphatic leukemia (HP:0006721)3.23869082
12Decreased central vision (HP:0007663)3.12655442
13Abnormality of B cell number (HP:0010975)3.09230094
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.05398265
15Purpura (HP:0000979)3.02487460
16Abnormal platelet function (HP:0011869)2.97972170
17Impaired platelet aggregation (HP:0003540)2.97972170
18Autoimmune hemolytic anemia (HP:0001890)2.97711327
19Abnormality of the prostate (HP:0008775)2.96065210
20Abnormality of the heme biosynthetic pathway (HP:0010472)2.95618445
21Elevated erythrocyte sedimentation rate (HP:0003565)2.91878375
22Attenuation of retinal blood vessels (HP:0007843)2.91693757
23Abolished electroretinogram (ERG) (HP:0000550)2.81870596
24Stomach cancer (HP:0012126)2.80582035
25Pancreatic cysts (HP:0001737)2.77806606
26Abnormal rod and cone electroretinograms (HP:0008323)2.68519188
27Congenital stationary night blindness (HP:0007642)2.68408357
28Abnormality of the renal cortex (HP:0011035)2.62529685
29Renal cortical cysts (HP:0000803)2.60622688
30B lymphocytopenia (HP:0010976)2.47599199
31Pancreatic fibrosis (HP:0100732)2.44711158
32Abnormality of lateral ventricle (HP:0030047)2.41784468
33Acute myeloid leukemia (HP:0004808)2.39135845
34Gaze-evoked nystagmus (HP:0000640)2.38698146
35Poikilocytosis (HP:0004447)2.27360079
36Absent/shortened dynein arms (HP:0200106)2.27259838
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.27259838
38Encephalitis (HP:0002383)2.20841015
39Hypoproteinemia (HP:0003075)2.19811811
40Albinism (HP:0001022)2.19784080
41Abnormality of midbrain morphology (HP:0002418)2.18271853
42Molar tooth sign on MRI (HP:0002419)2.18271853
43Febrile seizures (HP:0002373)2.17773234
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.16834651
45Abnormal pupillary function (HP:0007686)2.14624098
46True hermaphroditism (HP:0010459)2.14127438
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09719103
48Abnormal protein N-linked glycosylation (HP:0012347)2.09719103
49Abnormal protein glycosylation (HP:0012346)2.09719103
50Abnormal glycosylation (HP:0012345)2.09719103
51Central scotoma (HP:0000603)2.07658617
52Thyroiditis (HP:0100646)2.03948931
533-Methylglutaconic aciduria (HP:0003535)2.03237195
54Ketosis (HP:0001946)2.02322071
55Spontaneous hematomas (HP:0007420)2.01891418
56Autoimmune thrombocytopenia (HP:0001973)2.00580968
57Aplastic anemia (HP:0001915)1.99195627
58Hyperlipoproteinemia (HP:0010980)1.98334622
59Eosinophilia (HP:0001880)1.96607594
60Constricted visual fields (HP:0001133)1.95213440
61Granulocytopenia (HP:0001913)1.91676520
62Tubulointerstitial nephritis (HP:0001970)1.91084142
63Chronic hepatic failure (HP:0100626)1.90880445
64Facial diplegia (HP:0001349)1.90635396
65Thrombocytosis (HP:0001894)1.87675387
66Hypothermia (HP:0002045)1.87428322
67Hyperventilation (HP:0002883)1.87361766
68Abnormality of eosinophils (HP:0001879)1.86711779
69Abnormality of T cell number (HP:0011839)1.86315331
70Agammaglobulinemia (HP:0004432)1.85567108
71Leukocytosis (HP:0001974)1.85014893
72Abnormality of T cells (HP:0002843)1.84208820
73Abnormality of T cell physiology (HP:0011840)1.83045020
74Protruding tongue (HP:0010808)1.82144799
75Increased neuronal autofluorescent lipopigment (HP:0002074)1.82101853
76Abnormal drinking behavior (HP:0030082)1.81620881
77Polydipsia (HP:0001959)1.81620881
78Myelodysplasia (HP:0002863)1.80991874
79Volvulus (HP:0002580)1.80330882
80Prostate neoplasm (HP:0100787)1.80317284
81Thyroid-stimulating hormone excess (HP:0002925)1.79480924
82Recurrent viral infections (HP:0004429)1.78540028
83Abnormality of the renal medulla (HP:0100957)1.78037079
84Recurrent fungal infections (HP:0002841)1.77022587
85Chronic otitis media (HP:0000389)1.76848936
86Amaurosis fugax (HP:0100576)1.76795393
87Chest pain (HP:0100749)1.76643810
88Ketoacidosis (HP:0001993)1.76339495
89Neoplasm of the tracheobronchial system (HP:0100552)1.74982432
90Alveolar cell carcinoma (HP:0006519)1.74973930
91Abnormality of male internal genitalia (HP:0000022)1.74795688
92Conjunctival telangiectasia (HP:0000524)1.73602902
93Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72725500
94Widely spaced teeth (HP:0000687)1.72638303
95Severe combined immunodeficiency (HP:0004430)1.72310148
96Medial flaring of the eyebrow (HP:0010747)1.71097675
97Cystic liver disease (HP:0006706)1.70024096
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69942055
99Congenital hepatic fibrosis (HP:0002612)1.69550110
100Nephronophthisis (HP:0000090)1.69068543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.34945793
2TAOK33.84888577
3TEC3.05032646
4NUAK12.79846409
5TXK2.68319493
6MAP4K22.32646612
7ADRBK22.10028502
8BTK1.85759161
9KIT1.85369504
10PIK3CG1.83212073
11FES1.74062793
12DAPK21.73760804
13BMPR1B1.69681382
14SYK1.68707600
15MATK1.62375684
16TNK21.60145422
17MKNK11.58542710
18RIPK41.55269183
19EIF2AK11.53829850
20MST41.51682344
21ITK1.46077370
22EIF2AK31.45107825
23MAPK131.43434190
24MKNK21.38614600
25ACVR1B1.28942489
26PINK11.28525839
27PLK41.27732357
28TRIM281.21759392
29INSRR1.19758741
30ZAK1.18662746
31BRSK21.16464096
32MAP4K11.14607749
33GRK11.13241089
34IKBKB1.12204907
35TLK11.10982644
36BMPR21.03915797
37LYN1.02407748
38MAP2K31.01966968
39BCKDK0.99499900
40TNIK0.99487869
41HCK0.98918176
42VRK10.96258462
43STK390.95320243
44WNK30.94725948
45TIE10.93023822
46FER0.92087047
47DAPK10.89918383
48PLK20.87920609
49IRAK10.87090957
50ADRBK10.84025449
51PRKCQ0.83355248
52MAP3K140.82916335
53MAPKAPK30.82328482
54CSF1R0.81941154
55PTK2B0.81313404
56MAP3K60.78057078
57FLT30.77540523
58OXSR10.77048329
59ZAP700.76928690
60STK30.74886466
61GRK50.73666765
62GRK60.71381673
63AKT30.70294700
64MAP3K50.70187576
65MAP3K40.69917303
66LCK0.69748448
67MAP2K60.68028011
68JAK30.64985887
69RPS6KB20.64234580
70JAK10.62661691
71CAMKK20.61625595
72HIPK20.61508707
73MARK30.60018218
74TRPM70.59093181
75CSNK1G30.58969779
76CCNB10.57732510
77NLK0.55784763
78TBK10.50676820
79PAK30.49667150
80CSNK1G20.49248171
81ABL10.48732725
82MAPKAPK50.48116592
83IGF1R0.48041475
84MAP2K40.47984204
85CSNK1G10.46285648
86PIK3CA0.44518057
87PIM10.42300904
88BMX0.42215757
89EIF2AK20.41670462
90PRKCE0.41305304
91TGFBR10.41163647
92ERBB30.40424746
93RPS6KA50.39859702
94MYLK0.38594391
95VRK20.37578347
96IKBKE0.37562452
97MINK10.37232593
98CSNK1A1L0.36521437
99PRKG10.35761285
100TAF10.35314096

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.32634500
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51281095
3Linoleic acid metabolism_Homo sapiens_hsa005912.29345380
4Asthma_Homo sapiens_hsa053102.20771624
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.19450422
6Phototransduction_Homo sapiens_hsa047442.14281911
7Arachidonic acid metabolism_Homo sapiens_hsa005902.07076867
8Nitrogen metabolism_Homo sapiens_hsa009102.05955270
9SNARE interactions in vesicular transport_Homo sapiens_hsa041301.96553779
10Hematopoietic cell lineage_Homo sapiens_hsa046401.90825304
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74733324
12Butanoate metabolism_Homo sapiens_hsa006501.69792980
13Ether lipid metabolism_Homo sapiens_hsa005651.66838873
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65527342
15Graft-versus-host disease_Homo sapiens_hsa053321.65142201
16Primary immunodeficiency_Homo sapiens_hsa053401.60907219
17Allograft rejection_Homo sapiens_hsa053301.60712697
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.59785469
19Non-homologous end-joining_Homo sapiens_hsa034501.59128243
20Type I diabetes mellitus_Homo sapiens_hsa049401.51411439
21Homologous recombination_Homo sapiens_hsa034401.46363162
22Long-term depression_Homo sapiens_hsa047301.42728444
23Olfactory transduction_Homo sapiens_hsa047401.41526077
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40535909
25Regulation of autophagy_Homo sapiens_hsa041401.39544276
26Autoimmune thyroid disease_Homo sapiens_hsa053201.33970989
27Fanconi anemia pathway_Homo sapiens_hsa034601.33461593
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29071821
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26189193
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24226944
31Serotonergic synapse_Homo sapiens_hsa047261.23657068
32Tryptophan metabolism_Homo sapiens_hsa003801.22764115
33Propanoate metabolism_Homo sapiens_hsa006401.20996320
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20812736
35Dorso-ventral axis formation_Homo sapiens_hsa043201.19765844
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.18076742
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17296856
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15770346
39Peroxisome_Homo sapiens_hsa041461.11438507
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10467119
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10185011
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06646406
43Taste transduction_Homo sapiens_hsa047421.05942235
44Salivary secretion_Homo sapiens_hsa049701.05540500
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04248193
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.02313304
47ABC transporters_Homo sapiens_hsa020100.97996034
48Pancreatic secretion_Homo sapiens_hsa049720.96810190
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.95165808
50Renin secretion_Homo sapiens_hsa049240.93829116
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88822149
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86316535
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.86233793
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.85789136
55B cell receptor signaling pathway_Homo sapiens_hsa046620.82985373
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.82921694
57Rheumatoid arthritis_Homo sapiens_hsa053230.80167422
58Leishmaniasis_Homo sapiens_hsa051400.79273024
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76641953
60Circadian entrainment_Homo sapiens_hsa047130.76593991
61Purine metabolism_Homo sapiens_hsa002300.76282959
62Calcium signaling pathway_Homo sapiens_hsa040200.75444429
63Chemical carcinogenesis_Homo sapiens_hsa052040.74833082
64Selenocompound metabolism_Homo sapiens_hsa004500.74464336
65Fatty acid elongation_Homo sapiens_hsa000620.70206911
66Basal transcription factors_Homo sapiens_hsa030220.69086074
67T cell receptor signaling pathway_Homo sapiens_hsa046600.67918119
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66999456
69Glycerolipid metabolism_Homo sapiens_hsa005610.66982329
70Ovarian steroidogenesis_Homo sapiens_hsa049130.65048349
71Sphingolipid metabolism_Homo sapiens_hsa006000.64051548
72Measles_Homo sapiens_hsa051620.64016920
73Morphine addiction_Homo sapiens_hsa050320.62711798
74Chemokine signaling pathway_Homo sapiens_hsa040620.62143720
75Staphylococcus aureus infection_Homo sapiens_hsa051500.61799010
76Legionellosis_Homo sapiens_hsa051340.59317238
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58111408
78RNA degradation_Homo sapiens_hsa030180.57854391
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56552900
80Herpes simplex infection_Homo sapiens_hsa051680.54145850
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49694534
82Antigen processing and presentation_Homo sapiens_hsa046120.49476384
83One carbon pool by folate_Homo sapiens_hsa006700.47927073
84African trypanosomiasis_Homo sapiens_hsa051430.47658138
85Fatty acid degradation_Homo sapiens_hsa000710.45244107
86Mismatch repair_Homo sapiens_hsa034300.44118299
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.43712598
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43170627
89Oxytocin signaling pathway_Homo sapiens_hsa049210.42958179
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42125886
91Acute myeloid leukemia_Homo sapiens_hsa052210.41696222
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40960488
93Sulfur metabolism_Homo sapiens_hsa009200.40737462
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40362876
95Collecting duct acid secretion_Homo sapiens_hsa049660.39586704
96Fatty acid metabolism_Homo sapiens_hsa012120.39385431
97Base excision repair_Homo sapiens_hsa034100.38636186
98beta-Alanine metabolism_Homo sapiens_hsa004100.37700020
99Retinol metabolism_Homo sapiens_hsa008300.37373747
100RNA polymerase_Homo sapiens_hsa030200.36153773

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