ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	7.61410984
2	otic vesicle formation (GO:0030916)	6.95331510
3	pyrimidine nucleobase catabolic process (GO:0006208)	5.30098777
4	nonmotile primary cilium assembly (GO:0035058)	5.03819132
5	cellular biogenic amine catabolic process (GO:0042402)	4.63633445
6	amine catabolic process (GO:0009310)	4.63633445
7	establishment of mitochondrion localization (GO:0051654)	4.43891940
8	coenzyme catabolic process (GO:0009109)	4.29894484
9	nucleobase catabolic process (GO:0046113)	4.06959090
10	cornea development in camera-type eye (GO:0061303)	4.04762416
11	urinary tract smooth muscle contraction (GO:0014848)	4.00320059
12	respiratory system process (GO:0003016)	3.99535222
13	negative regulation of axonogenesis (GO:0050771)	3.90113841
14	response to muscle activity (GO:0014850)	3.87022100
15	resolution of meiotic recombination intermediates (GO:0000712)	3.83707245
16	axonal fasciculation (GO:0007413)	3.78716765
17	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.67866120
18	mitochondrion transport along microtubule (GO:0047497)	3.67866120
19	cell proliferation in forebrain (GO:0021846)	3.52993092
20	glycosphingolipid biosynthetic process (GO:0006688)	3.52038678
21	positive regulation of mitochondrial fission (GO:0090141)	3.49319536
22	negative regulation of telomere maintenance (GO:0032205)	3.37669598
23	glycine transport (GO:0015816)	3.36290350
24	protein-cofactor linkage (GO:0018065)	3.35178992
25	axon extension (GO:0048675)	3.32523177
26	regulation of cilium movement (GO:0003352)	3.31282877
27	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.26573416
28	regulation of autophagic vacuole assembly (GO:2000785)	3.24502335
29	telomere maintenance via semi-conservative replication (GO:0032201)	3.20908511
30	neuron recognition (GO:0008038)	3.18620332
31	oligosaccharide biosynthetic process (GO:0009312)	3.15390582
32	behavioral response to nicotine (GO:0035095)	3.15386708
33	neurotransmitter-gated ion channel clustering (GO:0072578)	3.09064902
34	retinal rod cell development (GO:0046548)	3.07252276
35	presynaptic membrane assembly (GO:0097105)	3.03805199
36	isoprenoid biosynthetic process (GO:0008299)	3.02970549
37	postsynaptic membrane organization (GO:0001941)	3.02374130
38	peroxisome fission (GO:0016559)	3.01843206
39	auditory behavior (GO:0031223)	3.00396898
40	DNA double-strand break processing (GO:0000729)	2.95773832
41	serine family amino acid catabolic process (GO:0009071)	2.92188489
42	cilium morphogenesis (GO:0060271)	2.88311146
43	seminiferous tubule development (GO:0072520)	2.86208377
44	photoreceptor cell development (GO:0042461)	2.85207724
45	polyamine metabolic process (GO:0006595)	2.84695006
46	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.83749993
47	cerebellar Purkinje cell differentiation (GO:0021702)	2.83610159
48	regulation of collateral sprouting (GO:0048670)	2.83144057
49	eye photoreceptor cell development (GO:0042462)	2.83118095
50	regulation of microtubule-based movement (GO:0060632)	2.82448308
51	cholesterol biosynthetic process (GO:0006695)	2.80929622
52	tachykinin receptor signaling pathway (GO:0007217)	2.79623574
53	neuromuscular synaptic transmission (GO:0007274)	2.79186683
54	negative regulation of response to food (GO:0032096)	2.77650331
55	negative regulation of appetite (GO:0032099)	2.77650331
56	tryptophan catabolic process (GO:0006569)	2.74615462
57	indole-containing compound catabolic process (GO:0042436)	2.74615462
58	indolalkylamine catabolic process (GO:0046218)	2.74615462
59	iron coordination entity transport (GO:1901678)	2.74048980
60	detection of light stimulus involved in sensory perception (GO:0050962)	2.73874606
61	detection of light stimulus involved in visual perception (GO:0050908)	2.73874606
62	ribonucleoprotein complex disassembly (GO:0032988)	2.73187321
63	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.71110194
64	organelle disassembly (GO:1903008)	2.69613151
65	mitochondrion degradation (GO:0000422)	2.68718691
66	neuron projection extension (GO:1990138)	2.67347929
67	positive regulation of protein kinase C signaling (GO:0090037)	2.67335806
68	forebrain neuron differentiation (GO:0021879)	2.67189269
69	dicarboxylic acid catabolic process (GO:0043649)	2.66421428
70	activation of protein kinase B activity (GO:0032148)	2.65464845
71	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.64460366
72	cell migration in hindbrain (GO:0021535)	2.57911146
73	synapsis (GO:0007129)	2.56310206
74	neuronal action potential propagation (GO:0019227)	2.54243555
75	DNA replication initiation (GO:0006270)	2.53653664
76	presynaptic membrane organization (GO:0097090)	2.53551603
77	telomere maintenance via recombination (GO:0000722)	2.52234993
78	regulation of vacuole organization (GO:0044088)	2.51577079
79	mechanosensory behavior (GO:0007638)	2.51248197
80	anterograde axon cargo transport (GO:0008089)	2.49017221
81	negative regulation of transcription by competitive promoter binding (GO:0010944)	2.48629981
82	protein localization to synapse (GO:0035418)	2.47240170
83	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.46186778
84	regulation of gene silencing by RNA (GO:0060966)	2.43190477
85	regulation of posttranscriptional gene silencing (GO:0060147)	2.43190477
86	regulation of gene silencing by miRNA (GO:0060964)	2.43190477
87	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.42090410
88	secondary metabolite biosynthetic process (GO:0044550)	2.41862974
89	L-methionine salvage (GO:0071267)	2.41668520
90	L-methionine biosynthetic process (GO:0071265)	2.41668520
91	amino acid salvage (GO:0043102)	2.41668520
92	water-soluble vitamin biosynthetic process (GO:0042364)	2.41131981
93	anterograde synaptic vesicle transport (GO:0048490)	2.41018732
94	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.40751600
95	membrane depolarization during action potential (GO:0086010)	2.40741477
96	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.40529845
97	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.39934968
98	sulfation (GO:0051923)	2.37927876
99	regulation of action potential (GO:0098900)	2.37899340
100	dopamine transport (GO:0015872)	2.37056480

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.10408718
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.92836885
3	VDR_22108803_ChIP-Seq_LS180_Human	3.38809986
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.19709231
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.19171219
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.91649681
7	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.47689666
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.45329347
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.39158844
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.38808639
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.17046486
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.10889753
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.07769646
14	FUS_26573619_Chip-Seq_HEK293_Human	2.06566738
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04628048
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00183360
17	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.98417064
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98417064
19	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.95127113
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.92753219
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89899908
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.87797075
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.86657667
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.80122379
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.77492528
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.74629901
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73441042
28	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.69981255
29	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.69818470
30	EWS_26573619_Chip-Seq_HEK293_Human	1.63696074
31	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.60378567
32	REST_21632747_ChIP-Seq_MESCs_Mouse	1.59934350
33	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.57719674
34	P300_19829295_ChIP-Seq_ESCs_Human	1.57403009
35	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.53227160
36	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.46049753
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.45952704
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.43938108
39	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.43832099
40	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.43724480
41	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.43724480
42	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.43559910
43	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.41883595
44	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.38838906
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.36679739
46	ER_23166858_ChIP-Seq_MCF-7_Human	1.35131306
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.34511629
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34163298
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.33729860
50	TAF15_26573619_Chip-Seq_HEK293_Human	1.33610395
51	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33047664
52	NCOR_22424771_ChIP-Seq_293T_Human	1.30231949
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.29820523
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29820523
55	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.29612370
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29582892
57	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.28809200
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26718560
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26493181
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25448703
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23803054
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21455557
63	BCAT_22108803_ChIP-Seq_LS180_Human	1.20873078
64	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.20642910
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.19113892
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18284353
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17214534
68	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16619069
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15547844
70	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14310928
71	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.14306282
72	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.13425515
73	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.12770461
74	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12711373
75	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.12339199
76	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11205256
77	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.09924798
78	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09263446
79	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.06372553
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03310035
81	AR_20517297_ChIP-Seq_VCAP_Human	1.03267815
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02641693
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.98075714
84	MYC_18940864_ChIP-ChIP_HL60_Human	0.97646057
85	TCF4_23295773_ChIP-Seq_U87_Human	0.96757033
86	AR_25329375_ChIP-Seq_VCAP_Human	0.96570567
87	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.96485126
88	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96096620
89	STAT3_23295773_ChIP-Seq_U87_Human	0.94699374
90	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.94585556
91	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94434950
92	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93314497
93	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.93074522
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92551118
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.92239510
96	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.91040214
97	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.90678904
98	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.88388130
99	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.88379077
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.86019341

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004858_abnormal_nervous_system	6.83852182
2	MP0003122_maternal_imprinting	3.11418299
3	MP0004142_abnormal_muscle_tone	3.07376737
4	MP0001529_abnormal_vocalization	2.91012026
5	MP0005423_abnormal_somatic_nervous	2.90986295
6	MP0003136_yellow_coat_color	2.62353832
7	MP0009046_muscle_twitch	2.45525408
8	MP0001188_hyperpigmentation	2.34549614
9	MP0003880_abnormal_central_pattern	2.24738144
10	MP0003121_genomic_imprinting	2.19997990
11	MP0000569_abnormal_digit_pigmentation	2.13435201
12	MP0006276_abnormal_autonomic_nervous	2.13196403
13	MP0003806_abnormal_nucleotide_metabolis	2.10169270
14	MP0001984_abnormal_olfaction	2.01871653
15	MP0002272_abnormal_nervous_system	1.78981886
16	MP0000372_irregular_coat_pigmentation	1.77916739
17	MP0005394_taste/olfaction_phenotype	1.74352966
18	MP0005499_abnormal_olfactory_system	1.74352966
19	MP0003315_abnormal_perineum_morphology	1.70650578
20	MP0008789_abnormal_olfactory_epithelium	1.70438543
21	MP0002160_abnormal_reproductive_system	1.66575668
22	MP0005551_abnormal_eye_electrophysiolog	1.65715698
23	MP0002138_abnormal_hepatobiliary_system	1.63355174
24	MP0002837_dystrophic_cardiac_calcinosis	1.62877556
25	MP0002063_abnormal_learning/memory/cond	1.52294833
26	MP0002572_abnormal_emotion/affect_behav	1.47298153
27	MP0003123_paternal_imprinting	1.43077604
28	MP0004885_abnormal_endolymph	1.41316300
29	MP0003868_abnormal_feces_composition	1.38287722
30	MP0003635_abnormal_synaptic_transmissio	1.37511534
31	MP0002184_abnormal_innervation	1.37404291
32	MP0006072_abnormal_retinal_apoptosis	1.36475051
33	MP0002938_white_spotting	1.35530265
34	MP0002928_abnormal_bile_duct	1.32433086
35	MP0008058_abnormal_DNA_repair	1.31077297
36	MP0004215_abnormal_myocardial_fiber	1.28988070
37	MP0005174_abnormal_tail_pigmentation	1.27976854
38	MP0000778_abnormal_nervous_system	1.27752266
39	MP0002139_abnormal_hepatobiliary_system	1.27605895
40	MP0002653_abnormal_ependyma_morphology	1.27548561
41	MP0000537_abnormal_urethra_morphology	1.27152059
42	MP0004924_abnormal_behavior	1.26785073
43	MP0005386_behavior/neurological_phenoty	1.26785073
44	MP0003879_abnormal_hair_cell	1.26618792
45	MP0001986_abnormal_taste_sensitivity	1.26251892
46	MP0010386_abnormal_urinary_bladder	1.25925106
47	MP0009745_abnormal_behavioral_response	1.24237918
48	MP0004270_analgesia	1.20733486
49	MP0009697_abnormal_copulation	1.18937871
50	MP0009780_abnormal_chondrocyte_physiolo	1.18883128
51	MP0002064_seizures	1.17121290
52	MP0005187_abnormal_penis_morphology	1.16870037
53	MP0005084_abnormal_gallbladder_morpholo	1.14916368
54	MP0000013_abnormal_adipose_tissue	1.11397178
55	MP0002734_abnormal_mechanical_nocicepti	1.11095228
56	MP0004133_heterotaxia	1.10916217
57	MP0001440_abnormal_grooming_behavior	1.10609991
58	MP0001324_abnormal_eye_pigmentation	1.10229625
59	MP0001968_abnormal_touch/_nociception	1.09486468
60	MP0003385_abnormal_body_wall	1.08771198
61	MP0002882_abnormal_neuron_morphology	1.08647358
62	MP0002067_abnormal_sensory_capabilities	1.07075041
63	MP0006035_abnormal_mitochondrial_morpho	1.06660941
64	MP0003828_pulmonary_edema	1.06182542
65	MP0005253_abnormal_eye_physiology	1.04342392
66	MP0002735_abnormal_chemical_nociception	1.04048009
67	MP0000749_muscle_degeneration	1.02825553
68	MP0003075_altered_response_to	1.02321974
69	MP0002752_abnormal_somatic_nervous	1.00121610
70	MP0001485_abnormal_pinna_reflex	0.99115484
71	MP0002733_abnormal_thermal_nociception	0.97177640
72	MP0002557_abnormal_social/conspecific_i	0.96754703
73	MP0003567_abnormal_fetal_cardiomyocyte	0.95497099
74	MP0001970_abnormal_pain_threshold	0.94926358
75	MP0003646_muscle_fatigue	0.94162425
76	MP0002277_abnormal_respiratory_mucosa	0.93670390
77	MP0001486_abnormal_startle_reflex	0.92242794
78	MP0002295_abnormal_pulmonary_circulatio	0.91936978
79	MP0005075_abnormal_melanosome_morpholog	0.91905988
80	MP0002066_abnormal_motor_capabilities/c	0.89827806
81	MP0004859_abnormal_synaptic_plasticity	0.88973073
82	MP0000955_abnormal_spinal_cord	0.86203517
83	MP0001502_abnormal_circadian_rhythm	0.84129874
84	MP0008877_abnormal_DNA_methylation	0.82727044
85	MP0006292_abnormal_olfactory_placode	0.82229817
86	MP0001905_abnormal_dopamine_level	0.81664127
87	MP0002876_abnormal_thyroid_physiology	0.81486994
88	MP0002736_abnormal_nociception_after	0.79598981
89	MP0005330_cardiomyopathy	0.78395109
90	MP0005645_abnormal_hypothalamus_physiol	0.77833960
91	MP0005360_urolithiasis	0.76882832
92	MP0002095_abnormal_skin_pigmentation	0.73253324
93	MP0004811_abnormal_neuron_physiology	0.73239239
94	MP0005389_reproductive_system_phenotype	0.72706129
95	MP0000538_abnormal_urinary_bladder	0.72427972
96	MP0005365_abnormal_bile_salt	0.72206751
97	MP0000026_abnormal_inner_ear	0.71855844
98	MP0002233_abnormal_nose_morphology	0.69281544
99	MP0001963_abnormal_hearing_physiology	0.68129553
100	MP0000631_abnormal_neuroendocrine_gland	0.67906503

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Failure to thrive in infancy (HP:0001531)	5.97706675
2	Abnormality of the labia minora (HP:0012880)	5.11486194
3	True hermaphroditism (HP:0010459)	4.99852623
4	Gait imbalance (HP:0002141)	4.85833915
5	Pancreatic fibrosis (HP:0100732)	4.64410770
6	Abnormal hair whorl (HP:0010721)	4.41406715
7	Congenital primary aphakia (HP:0007707)	4.39458434
8	Atonic seizures (HP:0010819)	4.23498525
9	Pancreatic cysts (HP:0001737)	4.21743807
10	Polyphagia (HP:0002591)	4.15253111
11	Medial flaring of the eyebrow (HP:0010747)	4.07781916
12	Nephrogenic diabetes insipidus (HP:0009806)	4.02937339
13	Poor coordination (HP:0002370)	3.83368303
14	Poor suck (HP:0002033)	3.69607589
15	Abnormality of midbrain morphology (HP:0002418)	3.47685232
16	Molar tooth sign on MRI (HP:0002419)	3.47685232
17	Vaginal atresia (HP:0000148)	3.40080783
18	Specific learning disability (HP:0001328)	3.33922040
19	Genital tract atresia (HP:0001827)	3.33852877
20	Cystic liver disease (HP:0006706)	3.25060791
21	Oligomenorrhea (HP:0000876)	3.19130873
22	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.15906459
23	Nephronophthisis (HP:0000090)	3.09722064
24	Sclerocornea (HP:0000647)	3.02532556
25	Rimmed vacuoles (HP:0003805)	2.88015223
26	Abnormal protein N-linked glycosylation (HP:0012347)	2.87814207
27	Abnormal protein glycosylation (HP:0012346)	2.87814207
28	Abnormal glycosylation (HP:0012345)	2.87814207
29	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.87814207
30	Hip dysplasia (HP:0001385)	2.83391034
31	Absent/shortened dynein arms (HP:0200106)	2.78494403
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.78494403
33	Absence seizures (HP:0002121)	2.74228010
34	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.72882080
35	Febrile seizures (HP:0002373)	2.68234902
36	Epileptic encephalopathy (HP:0200134)	2.66857434
37	Limb dystonia (HP:0002451)	2.65942955
38	Pendular nystagmus (HP:0012043)	2.63625292
39	Anencephaly (HP:0002323)	2.61998735
40	Chronic hepatic failure (HP:0100626)	2.61526886
41	Male pseudohermaphroditism (HP:0000037)	2.61225389
42	Renal cortical cysts (HP:0000803)	2.50552152
43	Global brain atrophy (HP:0002283)	2.47947261
44	Postaxial foot polydactyly (HP:0001830)	2.45316958
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.43349975
46	Furrowed tongue (HP:0000221)	2.43162956
47	Aplasia/Hypoplasia of the lens (HP:0008063)	2.39987120
48	Urinary urgency (HP:0000012)	2.37646304
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.32465777
50	Astigmatism (HP:0000483)	2.31332708
51	Abnormality of the renal medulla (HP:0100957)	2.27622814
52	Nasal speech (HP:0001611)	2.27598941
53	Abnormal ciliary motility (HP:0012262)	2.26863775
54	Hyperglycinemia (HP:0002154)	2.26466207
55	Dialeptic seizures (HP:0011146)	2.24289538
56	Meckel diverticulum (HP:0002245)	2.22776411
57	Broad alveolar ridges (HP:0000187)	2.19159776
58	Focal motor seizures (HP:0011153)	2.18050149
59	Decreased testicular size (HP:0008734)	2.13866604
60	Abnormality of the ileum (HP:0001549)	2.09896483
61	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06633854
62	Abnormal respiratory epithelium morphology (HP:0012253)	2.06633854
63	Progressive cerebellar ataxia (HP:0002073)	2.05956776
64	Short foot (HP:0001773)	2.02995054
65	Abnormal eating behavior (HP:0100738)	2.01602260
66	Status epilepticus (HP:0002133)	2.00203680
67	Preaxial hand polydactyly (HP:0001177)	1.99424032
68	Clumsiness (HP:0002312)	1.97870887
69	Labial hypoplasia (HP:0000066)	1.96794579
70	White forelock (HP:0002211)	1.93013269
71	Generalized hypotonia (HP:0001290)	1.92059760
72	Postural instability (HP:0002172)	1.91431377
73	Absent speech (HP:0001344)	1.91123108
74	Congenital hepatic fibrosis (HP:0002612)	1.90781542
75	Aganglionic megacolon (HP:0002251)	1.86561825
76	Scrotal hypoplasia (HP:0000046)	1.86166451
77	Hypogonadotrophic hypogonadism (HP:0000044)	1.86089024
78	Broad foot (HP:0001769)	1.82654191
79	Reduced antithrombin III activity (HP:0001976)	1.82094101
80	Patchy hypopigmentation of hair (HP:0011365)	1.82086114
81	Abnormality of chromosome stability (HP:0003220)	1.81611775
82	Abnormality of DNA repair (HP:0003254)	1.80781603
83	Morphological abnormality of the middle ear (HP:0008609)	1.79724115
84	Narrow forehead (HP:0000341)	1.77969794
85	Postaxial hand polydactyly (HP:0001162)	1.75998623
86	Sleep apnea (HP:0010535)	1.74798908
87	Hypoplastic female external genitalia (HP:0012815)	1.74217090
88	Narrow nasal bridge (HP:0000446)	1.73718264
89	Abnormal biliary tract morphology (HP:0012440)	1.73594159
90	Oligohydramnios (HP:0001562)	1.72631767
91	Generalized tonic-clonic seizures (HP:0002069)	1.72177300
92	Increased corneal curvature (HP:0100692)	1.71734864
93	Keratoconus (HP:0000563)	1.71734864
94	Micropenis (HP:0000054)	1.71067104
95	Abnormal respiratory motile cilium physiology (HP:0012261)	1.70285542
96	Dyskinesia (HP:0100660)	1.69780836
97	Decreased central vision (HP:0007663)	1.68446240
98	Left ventricular hypertrophy (HP:0001712)	1.68435949
99	Acute necrotizing encephalopathy (HP:0006965)	1.68211836
100	Decreased muscle mass (HP:0003199)	1.67908096

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	6.85294317
2	MARK1	3.65922477
3	CASK	3.50799683
4	MAPK13	3.12423537
5	WNK3	2.78336253
6	CDK19	2.54140019
7	PRKD3	2.25934622
8	OBSCN	2.25514584
9	MAP3K9	2.21494473
10	PHKG2	1.96698503
11	PHKG1	1.96698503
12	DYRK3	1.94777563
13	NTRK3	1.87214711
14	DYRK2	1.80651140
15	MAP4K2	1.60391885
16	PNCK	1.60345463
17	TNIK	1.57349432
18	ARAF	1.54107087
19	BMPR1B	1.50051222
20	BCR	1.49665659
21	PRKCG	1.39307017
22	MAP2K7	1.38939825
23	TAF1	1.35636706
24	MARK3	1.34116286
25	LMTK2	1.31677670
26	ZAK	1.27768317
27	CAMK1	1.27459190
28	CSNK1G2	1.22275404
29	SRPK1	1.21213760
30	GRK1	1.20361649
31	EIF2AK3	1.19837250
32	OXSR1	1.14210547
33	ADRBK2	1.13899924
34	TLK1	1.11836571
35	PLK4	1.07458295
36	CSNK1G3	1.07152046
37	EPHB2	1.06697908
38	MINK1	0.98719008
39	WEE1	0.98379850
40	NTRK2	0.89468615
41	KSR1	0.89230800
42	BCKDK	0.87871424
43	NUAK1	0.86344736
44	WNK4	0.85689197
45	CSNK1A1L	0.85602748
46	CSNK1G1	0.85230176
47	STK39	0.84827653
48	PLK2	0.83852175
49	PRKD2	0.81052272
50	FRK	0.80385335
51	MUSK	0.79804982
52	PRKCQ	0.75650861
53	ERBB3	0.68536190
54	BRD4	0.67570347
55	PAK3	0.66597741
56	CDC7	0.65238090
57	RPS6KA2	0.63638909
58	NEK2	0.63243449
59	DYRK1A	0.63204281
60	RPS6KA4	0.62886564
61	VRK1	0.62601628
62	PLK1	0.60123357
63	MOS	0.58431812
64	PKN1	0.58148620
65	LATS1	0.57887043
66	ABL2	0.57483834
67	PRKACB	0.56001854
68	PRKCE	0.53446628
69	PBK	0.53256831
70	PRKCZ	0.52452647
71	CCNB1	0.52329004
72	PRKD1	0.50912598
73	PRKAA1	0.50472429
74	MAP3K13	0.50178036
75	CDK14	0.49635191
76	PRKCI	0.49307399
77	CSNK1A1	0.49119913
78	PRKCH	0.48149372
79	CSNK1D	0.45622528
80	MYLK	0.45184773
81	TRIM28	0.44989030
82	PRKG1	0.44905331
83	CDK5	0.44295475
84	SGK494	0.42468902
85	SGK223	0.42468902
86	PRKACA	0.41958750
87	BRAF	0.41869933
88	EPHA3	0.40208890
89	CAMK2A	0.39726779
90	NME1	0.38647886
91	ERBB2	0.38593488
92	INSRR	0.38550606
93	VRK2	0.37587615
94	AKT2	0.32869353
95	CDK11A	0.32368233
96	PIK3CA	0.32292304
97	CSNK1E	0.31020058
98	ROCK1	0.30228753
99	STK16	0.29709982
100	TAOK1	0.29431301

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.71971613
2	Sulfur relay system_Homo sapiens_hsa04122	2.76860758
3	Steroid biosynthesis_Homo sapiens_hsa00100	2.67244396
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.35380788
5	Parkinsons disease_Homo sapiens_hsa05012	2.27630785
6	Nicotine addiction_Homo sapiens_hsa05033	2.18659030
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05800023
8	Butanoate metabolism_Homo sapiens_hsa00650	1.96865094
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.91601565
10	Phototransduction_Homo sapiens_hsa04744	1.90043898
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.88242265
12	DNA replication_Homo sapiens_hsa03030	1.87759294
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.84859859
14	Regulation of autophagy_Homo sapiens_hsa04140	1.75681357
15	Basal transcription factors_Homo sapiens_hsa03022	1.74148842
16	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.67204119
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.66673998
18	Homologous recombination_Homo sapiens_hsa03440	1.63422524
19	Protein export_Homo sapiens_hsa03060	1.61235782
20	Alzheimers disease_Homo sapiens_hsa05010	1.54783235
21	Propanoate metabolism_Homo sapiens_hsa00640	1.50700433
22	GABAergic synapse_Homo sapiens_hsa04727	1.46797007
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.42300402
24	Olfactory transduction_Homo sapiens_hsa04740	1.40199906
25	Huntingtons disease_Homo sapiens_hsa05016	1.39201662
26	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.36628390
27	RNA polymerase_Homo sapiens_hsa03020	1.35006040
28	Peroxisome_Homo sapiens_hsa04146	1.33380172
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.33336518
30	Arginine and proline metabolism_Homo sapiens_hsa00330	1.27709263
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26530921
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.25639514
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.25338121
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24842110
35	Retinol metabolism_Homo sapiens_hsa00830	1.17382183
36	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.12684622
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12515582
38	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.10388391
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.07829094
40	RNA degradation_Homo sapiens_hsa03018	1.06980695
41	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.06935154
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04948985
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.00274506
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.00012096
45	Purine metabolism_Homo sapiens_hsa00230	0.98906147
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.95442719
47	Circadian rhythm_Homo sapiens_hsa04710	0.94446626
48	One carbon pool by folate_Homo sapiens_hsa00670	0.93644456
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93578591
50	Morphine addiction_Homo sapiens_hsa05032	0.92131665
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.89282161
52	Ribosome_Homo sapiens_hsa03010	0.88417907
53	Taste transduction_Homo sapiens_hsa04742	0.87997462
54	Circadian entrainment_Homo sapiens_hsa04713	0.87682212
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87074962
56	Oocyte meiosis_Homo sapiens_hsa04114	0.86572038
57	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.85952136
58	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.84924348
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.84246291
60	Axon guidance_Homo sapiens_hsa04360	0.81615826
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.80256561
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.78852190
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78329464
64	Metabolic pathways_Homo sapiens_hsa01100	0.77785178
65	Proteasome_Homo sapiens_hsa03050	0.77456406
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.76720290
67	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75711134
68	ABC transporters_Homo sapiens_hsa02010	0.74232665
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73014538
70	Amphetamine addiction_Homo sapiens_hsa05031	0.69753939
71	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.69561903
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.69097233
73	Fatty acid elongation_Homo sapiens_hsa00062	0.68481913
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.66277481
75	Dopaminergic synapse_Homo sapiens_hsa04728	0.66174965
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64633964
77	AMPK signaling pathway_Homo sapiens_hsa04152	0.63173248
78	Mismatch repair_Homo sapiens_hsa03430	0.59679712
79	Cocaine addiction_Homo sapiens_hsa05030	0.59638805
80	Alcoholism_Homo sapiens_hsa05034	0.58733651
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.57808050
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57718903
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.55967107
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.55345916
85	Insulin secretion_Homo sapiens_hsa04911	0.55313065
86	Caffeine metabolism_Homo sapiens_hsa00232	0.54651531
87	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.53701189
88	Renin secretion_Homo sapiens_hsa04924	0.53350101
89	Spliceosome_Homo sapiens_hsa03040	0.53280257
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51500139
91	Serotonergic synapse_Homo sapiens_hsa04726	0.49582559
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48404634
93	PPAR signaling pathway_Homo sapiens_hsa03320	0.48177267
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47236884
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46667832
96	Folate biosynthesis_Homo sapiens_hsa00790	0.46144318
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45741984
98	Non-homologous end-joining_Homo sapiens_hsa03450	0.45471939
99	Base excision repair_Homo sapiens_hsa03410	0.44779619
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.44627696

GCSHP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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