ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	CENP-A containing nucleosome assembly (GO:0034080)	4.65257618
2	chromatin remodeling at centromere (GO:0031055)	4.50116899
3	L-serine metabolic process (GO:0006563)	4.39920042
4	regulation of mitochondrial translation (GO:0070129)	4.17290301
5	proteasome assembly (GO:0043248)	4.10314236
6	DNA strand elongation involved in DNA replication (GO:0006271)	3.91540242
7	histone exchange (GO:0043486)	3.80936062
8	telomere maintenance via semi-conservative replication (GO:0032201)	3.79262674
9	establishment of integrated proviral latency (GO:0075713)	3.74413046
10	DNA strand elongation (GO:0022616)	3.72896248
11	DNA replication-independent nucleosome assembly (GO:0006336)	3.72762415
12	DNA replication-independent nucleosome organization (GO:0034724)	3.72762415
13	IMP biosynthetic process (GO:0006188)	3.57820746
14	oxidative phosphorylation (GO:0006119)	3.50223274
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.48096747
16	chaperone-mediated protein transport (GO:0072321)	3.47672840
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.43455987
18	DNA double-strand break processing (GO:0000729)	3.40636195
19	ribosome assembly (GO:0042255)	3.31951486
20	IMP metabolic process (GO:0046040)	3.24825332
21	telomere maintenance via recombination (GO:0000722)	3.24522379
22	mitotic metaphase plate congression (GO:0007080)	3.19840565
23	spliceosomal snRNP assembly (GO:0000387)	3.17187498
24	purine nucleobase biosynthetic process (GO:0009113)	3.17130145
25	peptidyl-arginine omega-N-methylation (GO:0035247)	3.15805996
26	protein localization to kinetochore (GO:0034501)	3.14422345
27	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.11451597
28	DNA replication-dependent nucleosome assembly (GO:0006335)	3.09924883
29	DNA replication-dependent nucleosome organization (GO:0034723)	3.09924883
30	serine family amino acid biosynthetic process (GO:0009070)	3.08215860
31	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.07793521
32	mitotic recombination (GO:0006312)	3.06640875
33	DNA damage response, detection of DNA damage (GO:0042769)	3.05942458
34	protein targeting to mitochondrion (GO:0006626)	3.05892012
35	regulation of helicase activity (GO:0051095)	3.04745859
36	protein localization to chromosome, centromeric region (GO:0071459)	3.03145508
37	serine family amino acid catabolic process (GO:0009071)	3.00850277
38	ATP synthesis coupled proton transport (GO:0015986)	2.99671933
39	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.99671933
40	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.99381432
41	tRNA aminoacylation for protein translation (GO:0006418)	2.96396628
42	DNA replication initiation (GO:0006270)	2.95276199
43	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.94007064
44	DNA ligation (GO:0006266)	2.90929616
45	amino acid activation (GO:0043038)	2.90706139
46	tRNA aminoacylation (GO:0043039)	2.90706139
47	DNA replication checkpoint (GO:0000076)	2.90496063
48	glycine metabolic process (GO:0006544)	2.90217202
49	histone arginine methylation (GO:0034969)	2.89874099
50	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.89492025
51	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.89028831
52	establishment of viral latency (GO:0019043)	2.87994960
53	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.87459993
54	DNA unwinding involved in DNA replication (GO:0006268)	2.85434060
55	ribosomal small subunit assembly (GO:0000028)	2.85307879
56	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.85137936
57	cullin deneddylation (GO:0010388)	2.84065610
58	mitochondrial RNA metabolic process (GO:0000959)	2.83859300
59	protein localization to mitochondrion (GO:0070585)	2.83441588
60	folic acid-containing compound biosynthetic process (GO:0009396)	2.81805589
61	establishment of protein localization to mitochondrion (GO:0072655)	2.81737895
62	non-recombinational repair (GO:0000726)	2.79530162
63	double-strand break repair via nonhomologous end joining (GO:0006303)	2.79530162
64	formation of translation preinitiation complex (GO:0001731)	2.78377117
65	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.77630678
66	negative regulation of ligase activity (GO:0051352)	2.77630678
67	serine family amino acid metabolic process (GO:0009069)	2.75362570
68	nucleobase biosynthetic process (GO:0046112)	2.74766912
69	ATP-dependent chromatin remodeling (GO:0043044)	2.73530092
70	protein deneddylation (GO:0000338)	2.72958184
71	telomere maintenance via telomere lengthening (GO:0010833)	2.72449686
72	maturation of 5.8S rRNA (GO:0000460)	2.72386278
73	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.71665578
74	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.71665578
75	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.70110996
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.70110996
77	NADH dehydrogenase complex assembly (GO:0010257)	2.70110996
78	nucleobase-containing small molecule interconversion (GO:0015949)	2.68735654
79	rRNA modification (GO:0000154)	2.67681757
80	peptidyl-arginine N-methylation (GO:0035246)	2.67137639
81	peptidyl-arginine methylation (GO:0018216)	2.67137639
82	metaphase plate congression (GO:0051310)	2.66114680
83	base-excision repair (GO:0006284)	2.65159504
84	pseudouridine synthesis (GO:0001522)	2.62679186
85	ribosomal large subunit biogenesis (GO:0042273)	2.62477446
86	respiratory electron transport chain (GO:0022904)	2.62080743
87	branched-chain amino acid catabolic process (GO:0009083)	2.62056235
88	pteridine-containing compound biosynthetic process (GO:0042559)	2.61682134
89	mitotic sister chromatid segregation (GO:0000070)	2.61502179
90	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.61489558
91	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.60581033
92	de novo protein folding (GO:0006458)	2.60033303
93	regulation of translational fidelity (GO:0006450)	2.59338241
94	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.59246520
95	amino acid salvage (GO:0043102)	2.58954041
96	L-methionine salvage (GO:0071267)	2.58954041
97	L-methionine biosynthetic process (GO:0071265)	2.58954041
98	histone mRNA metabolic process (GO:0008334)	2.57168956
99	iron-sulfur cluster assembly (GO:0016226)	2.57015490
100	metallo-sulfur cluster assembly (GO:0031163)	2.57015490

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.56530217
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.43805649
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.35927022
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.35262834
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.54931257
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.35081782
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.17863194
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.17728357
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.12450294
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.07666843
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.01580476
12	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.91038835
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.88014665
14	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.81118860
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.78757977
16	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.59118388
17	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.58542119
18	AR_21909140_ChIP-Seq_LNCAP_Human	2.52610204
19	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.44894001
20	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.43162107
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.41241735
22	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.37326915
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34819322
24	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.28869033
25	GABP_19822575_ChIP-Seq_HepG2_Human	2.27377136
26	ELK1_19687146_ChIP-ChIP_HELA_Human	2.26735069
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.21388407
28	XRN2_22483619_ChIP-Seq_HELA_Human	2.20193434
29	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.14402632
30	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.09417498
31	FOXP3_21729870_ChIP-Seq_TREG_Human	2.08101613
32	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.05624426
33	TTF2_22483619_ChIP-Seq_HELA_Human	2.02522100
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.01785783
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.97296572
36	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.93152423
37	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.86876156
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.85115803
39	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.81250433
40	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.80391860
41	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.79500969
42	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.79362994
43	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.79283077
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.76448581
45	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.72528217
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72434320
47	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.65807762
48	ZNF263_19887448_ChIP-Seq_K562_Human	1.60652993
49	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.56462116
50	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.46639321
51	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45278980
52	IGF1R_20145208_ChIP-Seq_DFB_Human	1.44537918
53	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.40780078
54	KDM5A_27292631_Chip-Seq_BREAST_Human	1.39789335
55	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.38438088
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.37737161
57	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.37642388
58	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.31199462
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.30023664
60	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.26923090
61	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.20440461
62	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.19973374
63	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.17623433
64	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.16208471
65	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.14755531
66	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	1.12336950
67	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.10578745
68	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.08499024
69	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.06995475
70	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.05001843
71	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.04840840
72	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.02644581
73	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.02570352
74	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.02558926
75	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.01767457
76	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.00750167
77	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.00554201
78	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.98561775
79	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.98423776
80	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.96754645
81	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.94973318
82	ZNF274_21170338_ChIP-Seq_K562_Hela	0.90989496
83	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.89693256
84	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.89574828
85	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.88709386
86	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.87984602
87	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.85460462
88	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.83502926
89	FUS_26573619_Chip-Seq_HEK293_Human	0.82989269
90	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.82890735
91	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.81579915
92	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.81124250
93	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.79221687
94	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.78484774
95	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.76263385
96	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.76219819
97	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.75790431
98	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.75194073
99	IRF1_19129219_ChIP-ChIP_H3396_Human	0.74681883
100	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.74602093

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.77697001
2	MP0001529_abnormal_vocalization	3.52549584
3	MP0008058_abnormal_DNA_repair	3.43643871
4	MP0003693_abnormal_embryo_hatching	3.10615245
5	MP0009697_abnormal_copulation	2.97819055
6	MP0004957_abnormal_blastocyst_morpholog	2.96456910
7	MP0003111_abnormal_nucleus_morphology	2.80327598
8	MP0008932_abnormal_embryonic_tissue	2.66662839
9	MP0003806_abnormal_nucleotide_metabolis	2.60690535
10	MP0003077_abnormal_cell_cycle	2.45844176
11	MP0008789_abnormal_olfactory_epithelium	2.43288845
12	MP0003718_maternal_effect	2.09741525
13	MP0005394_taste/olfaction_phenotype	2.05410239
14	MP0005499_abnormal_olfactory_system	2.05410239
15	MP0006036_abnormal_mitochondrial_physio	2.02491303
16	MP0003186_abnormal_redox_activity	1.96398689
17	MP0008057_abnormal_DNA_replication	1.95109829
18	MP0004147_increased_porphyrin_level	1.92899242
19	MP0006035_abnormal_mitochondrial_morpho	1.79066089
20	MP0008007_abnormal_cellular_replicative	1.70042720
21	MP0006292_abnormal_olfactory_placode	1.68988943
22	MP0003786_premature_aging	1.65646612
23	MP0004233_abnormal_muscle_weight	1.61211205
24	MP0000749_muscle_degeneration	1.57195186
25	MP0003890_abnormal_embryonic-extraembry	1.53980771
26	MP0001730_embryonic_growth_arrest	1.47660074
27	MP0010030_abnormal_orbit_morphology	1.47489092
28	MP0001661_extended_life_span	1.44905498
29	MP0006072_abnormal_retinal_apoptosis	1.42046981
30	MP0003315_abnormal_perineum_morphology	1.33672704
31	MP0008995_early_reproductive_senescence	1.30897668
32	MP0000049_abnormal_middle_ear	1.30480791
33	MP0003567_abnormal_fetal_cardiomyocyte	1.29795122
34	MP0002233_abnormal_nose_morphology	1.29401827
35	MP0002234_abnormal_pharynx_morphology	1.28801714
36	MP0002160_abnormal_reproductive_system	1.28708475
37	MP0003937_abnormal_limbs/digits/tail_de	1.24816250
38	MP0001697_abnormal_embryo_size	1.24256372
39	MP0003136_yellow_coat_color	1.23975578
40	MP0002938_white_spotting	1.23934877
41	MP0002102_abnormal_ear_morphology	1.23011383
42	MP0005380_embryogenesis_phenotype	1.20873129
43	MP0001672_abnormal_embryogenesis/_devel	1.20873129
44	MP0003941_abnormal_skin_development	1.20083417
45	MP0003221_abnormal_cardiomyocyte_apopto	1.19743768
46	MP0005187_abnormal_penis_morphology	1.17394104
47	MP0000350_abnormal_cell_proliferation	1.16683425
48	MP0002269_muscular_atrophy	1.14801317
49	MP0001293_anophthalmia	1.14792769
50	MP0002084_abnormal_developmental_patter	1.13605831
51	MP0000358_abnormal_cell_content/	1.12256899
52	MP0001984_abnormal_olfaction	1.10361113
53	MP0002080_prenatal_lethality	1.10244107
54	MP0002085_abnormal_embryonic_tissue	1.08647472
55	MP0009672_abnormal_birth_weight	1.08078658
56	MP0000647_abnormal_sebaceous_gland	1.07033381
57	MP0002090_abnormal_vision	1.06880641
58	MP0001764_abnormal_homeostasis	1.06836573
59	MP0003119_abnormal_digestive_system	1.02407984
60	MP0002697_abnormal_eye_size	1.02385169
61	MP0000537_abnormal_urethra_morphology	1.01313209
62	MP0003121_genomic_imprinting	1.00843670
63	MP0004197_abnormal_fetal_growth/weight/	0.98972574
64	MP0003984_embryonic_growth_retardation	0.97999845
65	MP0002751_abnormal_autonomic_nervous	0.94851885
66	MP0002088_abnormal_embryonic_growth/wei	0.94344704
67	MP0001929_abnormal_gametogenesis	0.93145459
68	MP0002210_abnormal_sex_determination	0.93061861
69	MP0003385_abnormal_body_wall	0.91352495
70	MP0002111_abnormal_tail_morphology	0.91347138
71	MP0000751_myopathy	0.90160658
72	MP0009379_abnormal_foot_pigmentation	0.90106268
73	MP0001286_abnormal_eye_development	0.85573969
74	MP0000762_abnormal_tongue_morphology	0.85512490
75	MP0004133_heterotaxia	0.85070656
76	MP0001145_abnormal_male_reproductive	0.83030276
77	MP0005253_abnormal_eye_physiology	0.80085783
78	MP0003755_abnormal_palate_morphology	0.80052202
79	MP0000653_abnormal_sex_gland	0.79720329
80	MP0005330_cardiomyopathy	0.78480484
81	MP0009703_decreased_birth_body	0.78274639
82	MP0004145_abnormal_muscle_electrophysio	0.77542660
83	MP0000313_abnormal_cell_death	0.76902092
84	MP0003122_maternal_imprinting	0.76303472
85	MP0000750_abnormal_muscle_regeneration	0.76278145
86	MP0001188_hyperpigmentation	0.75988584
87	MP0005332_abnormal_amino_acid	0.74341713
88	MP0000566_synostosis	0.73304831
89	MP0006276_abnormal_autonomic_nervous	0.70076486
90	MP0005646_abnormal_pituitary_gland	0.69445327
91	MP0005391_vision/eye_phenotype	0.68732524
92	MP0003698_abnormal_male_reproductive	0.68501835
93	MP0003861_abnormal_nervous_system	0.66929563
94	MP0000747_muscle_weakness	0.66499032
95	MP0000579_abnormal_nail_morphology	0.65628152
96	MP0000631_abnormal_neuroendocrine_gland	0.65626201
97	MP0001727_abnormal_embryo_implantation	0.64331589
98	MP0009250_abnormal_appendicular_skeleto	0.63908876
99	MP0002086_abnormal_extraembryonic_tissu	0.63882733
100	MP0002822_catalepsy	0.63194308

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperglycinemia (HP:0002154)	5.05106515
2	Increased serum pyruvate (HP:0003542)	4.18455527
3	Abnormality of glycolysis (HP:0004366)	3.89118457
4	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.77023451
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.77023451
6	Hyperglycinuria (HP:0003108)	3.65229591
7	Acute encephalopathy (HP:0006846)	3.59407755
8	Abnormality of glycine metabolism (HP:0010895)	3.53047427
9	Abnormality of serine family amino acid metabolism (HP:0010894)	3.53047427
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.47785689
11	Acute necrotizing encephalopathy (HP:0006965)	3.47139347
12	Increased hepatocellular lipid droplets (HP:0006565)	3.29842837
13	Lipid accumulation in hepatocytes (HP:0006561)	3.25643793
14	Reduced antithrombin III activity (HP:0001976)	3.19044156
15	Exercise-induced muscle cramps (HP:0003710)	3.16590220
16	Abnormality of alanine metabolism (HP:0010916)	3.13617188
17	Hyperalaninemia (HP:0003348)	3.13617188
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.13617188
19	Abnormality of serum amino acid levels (HP:0003112)	3.07676309
20	Increased CSF lactate (HP:0002490)	3.07333756
21	Microvesicular hepatic steatosis (HP:0001414)	3.02859108
22	Mitochondrial inheritance (HP:0001427)	2.94201784
23	Hepatocellular necrosis (HP:0001404)	2.88724241
24	Cerebral edema (HP:0002181)	2.86138970
25	Hepatic necrosis (HP:0002605)	2.69796243
26	Increased intramyocellular lipid droplets (HP:0012240)	2.69736055
27	Progressive macrocephaly (HP:0004481)	2.66820589
28	Lactic acidosis (HP:0003128)	2.63742708
29	Increased serum lactate (HP:0002151)	2.63573759
30	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.60050576
31	Type I transferrin isoform profile (HP:0003642)	2.53998691
32	Exercise intolerance (HP:0003546)	2.51846077
33	Chromsome breakage (HP:0040012)	2.50939228
34	Colon cancer (HP:0003003)	2.46994781
35	Abnormality of the labia minora (HP:0012880)	2.43548015
36	Increased muscle lipid content (HP:0009058)	2.39425359
37	Cortical dysplasia (HP:0002539)	2.37601288
38	Multiple enchondromatosis (HP:0005701)	2.34884207
39	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.29617410
40	Abnormal protein N-linked glycosylation (HP:0012347)	2.29617410
41	Abnormal protein glycosylation (HP:0012346)	2.29617410
42	Abnormal glycosylation (HP:0012345)	2.29617410
43	Reticulocytopenia (HP:0001896)	2.29443262
44	Meckel diverticulum (HP:0002245)	2.25356444
45	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.25241199
46	Renal Fanconi syndrome (HP:0001994)	2.24590318
47	Birth length less than 3rd percentile (HP:0003561)	2.16715380
48	Abnormality of the ileum (HP:0001549)	2.15883034
49	Lethargy (HP:0001254)	2.12933243
50	Abnormality of the anterior horn cell (HP:0006802)	2.02900403
51	Degeneration of anterior horn cells (HP:0002398)	2.02900403
52	Abnormality of methionine metabolism (HP:0010901)	2.02253524
53	Myoglobinuria (HP:0002913)	1.97602064
54	Abnormality of placental membranes (HP:0011409)	1.95932667
55	Amniotic constriction ring (HP:0009775)	1.95932667
56	Rimmed vacuoles (HP:0003805)	1.95913902
57	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.94503240
58	Impulsivity (HP:0100710)	1.90703513
59	Abnormality of chromosome stability (HP:0003220)	1.90255077
60	Abnormality of the preputium (HP:0100587)	1.90097220
61	Generalized aminoaciduria (HP:0002909)	1.89504802
62	Abnormal lung lobation (HP:0002101)	1.88582039
63	Medulloblastoma (HP:0002885)	1.88067861
64	Ragged-red muscle fibers (HP:0003200)	1.87722595
65	Leukodystrophy (HP:0002415)	1.84552243
66	Retinal dysplasia (HP:0007973)	1.82940386
67	Hyperammonemia (HP:0001987)	1.81342229
68	Shoulder girdle muscle weakness (HP:0003547)	1.80472127
69	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.79448086
70	Postnatal microcephaly (HP:0005484)	1.77612522
71	Respiratory failure (HP:0002878)	1.77040827
72	Triphalangeal thumb (HP:0001199)	1.72045388
73	Methylmalonic acidemia (HP:0002912)	1.70554480
74	Rhabdomyolysis (HP:0003201)	1.69344564
75	Median cleft lip (HP:0000161)	1.68606103
76	Horseshoe kidney (HP:0000085)	1.67484090
77	Progressive muscle weakness (HP:0003323)	1.67323160
78	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.64910106
79	Hypoplastic pelvis (HP:0008839)	1.64879584
80	CNS demyelination (HP:0007305)	1.62774524
81	Cerebral hypomyelination (HP:0006808)	1.60282928
82	Small intestinal stenosis (HP:0012848)	1.57622378
83	Duodenal stenosis (HP:0100867)	1.57622378
84	Abnormalities of placenta or umbilical cord (HP:0001194)	1.57132915
85	Nephrogenic diabetes insipidus (HP:0009806)	1.56752102
86	Congenital primary aphakia (HP:0007707)	1.56524141
87	Split foot (HP:0001839)	1.56292712
88	Gout (HP:0001997)	1.55311797
89	Abnormality of fatty-acid metabolism (HP:0004359)	1.53960741
90	Spastic diplegia (HP:0001264)	1.51127092
91	Microglossia (HP:0000171)	1.48878609
92	Abnormality of the fetal cardiovascular system (HP:0010948)	1.48854301
93	Abnormal umbilical cord blood vessels (HP:0011403)	1.48854301
94	Single umbilical artery (HP:0001195)	1.48854301
95	3-Methylglutaconic aciduria (HP:0003535)	1.48441741
96	Hemivertebrae (HP:0002937)	1.48410296
97	Muscle fiber inclusion bodies (HP:0100299)	1.48231596
98	Respiratory difficulties (HP:0002880)	1.48027336
99	Thyroid-stimulating hormone excess (HP:0002925)	1.47303765
100	Abnormal number of erythroid precursors (HP:0012131)	1.47221519

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	4.27438378
2	PBK	3.75343063
3	SRPK1	3.08966025
4	BUB1	2.93297509
5	CDC7	2.69182602
6	TSSK6	2.38446539
7	VRK2	2.34663638
8	BCR	2.28758227
9	BCKDK	2.27683195
10	EIF2AK1	2.23228401
11	TTK	2.19223091
12	SCYL2	2.08843745
13	WEE1	2.07535031
14	PLK4	2.03813016
15	TRIM28	2.02216013
16	NME2	1.96101243
17	PINK1	1.87320770
18	MAP4K2	1.83294904
19	ZAK	1.82377291
20	EIF2AK3	1.82165486
21	CSNK1G3	1.80871789
22	MAP2K7	1.75308287
23	CSNK1A1L	1.71784002
24	PLK3	1.59589281
25	CSNK1G1	1.55247029
26	VRK1	1.50659587
27	PLK1	1.45888215
28	NEK2	1.44841566
29	CSNK1G2	1.43813548
30	MKNK1	1.43704210
31	WNK3	1.39417825
32	OBSCN	1.38734635
33	AURKB	1.26198554
34	RPS6KA4	1.26088947
35	DYRK3	1.21539514
36	CHEK2	1.16038102
37	DYRK2	1.11038728
38	ATR	1.07235977
39	TESK2	1.06364873
40	NME1	1.06149913
41	CCNB1	1.03519753
42	MAP3K4	1.01101405
43	PAK4	0.99462158
44	ERBB3	0.98008446
45	ARAF	0.96667001
46	PNCK	0.94081694
47	LATS1	0.92259363
48	MST4	0.90207875
49	MET	0.89726748
50	CDK19	0.89610273
51	AURKA	0.87285310
52	CDK7	0.82737533
53	FLT3	0.82675264
54	TAF1	0.82477413
55	LIMK1	0.81955332
56	ERBB4	0.80942096
57	PIM2	0.79745982
58	LATS2	0.79436424
59	TESK1	0.71417135
60	STK38L	0.71411780
61	CDK14	0.71197405
62	CHEK1	0.69850750
63	STK16	0.69335465
64	BRSK2	0.67652665
65	BRSK1	0.67324776
66	ATM	0.64323083
67	DAPK1	0.63716201
68	CSNK2A1	0.63696796
69	MST1R	0.63254733
70	RPS6KB2	0.62918242
71	PDK2	0.62897640
72	KDR	0.62749582
73	AKT2	0.61491333
74	CSNK2A2	0.59991871
75	EIF2AK2	0.59896188
76	BRAF	0.59181864
77	CDK8	0.56528431
78	EPHA2	0.54823840
79	CSNK1A1	0.52140547
80	CDK18	0.51567879
81	MAPKAPK5	0.49274114
82	MAP3K9	0.48987842
83	PLK2	0.46823272
84	CDK11A	0.45795770
85	CDK15	0.45565583
86	MINK1	0.45320112
87	CDK1	0.43768906
88	CSNK1E	0.43574853
89	MAP3K5	0.43394241
90	PAK1	0.42399288
91	RPS6KA5	0.42205913
92	PHKG2	0.40305935
93	PHKG1	0.40305935
94	CAMK2G	0.40135771
95	CDK2	0.38262366
96	MKNK2	0.36397803
97	NUAK1	0.34578952
98	CAMK2B	0.31109534
99	RAF1	0.30778517
100	MAP3K8	0.28537498

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.33253707
2	Proteasome_Homo sapiens_hsa03050	2.91966607
3	Mismatch repair_Homo sapiens_hsa03430	2.88370959
4	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.39599748
5	Base excision repair_Homo sapiens_hsa03410	2.33747384
6	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.31215963
7	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.31176337
8	Protein export_Homo sapiens_hsa03060	2.22162092
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.15208882
10	Parkinsons disease_Homo sapiens_hsa05012	2.13917182
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.12601785
12	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.11615447
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.10407115
14	Propanoate metabolism_Homo sapiens_hsa00640	2.08959542
15	Ribosome_Homo sapiens_hsa03010	2.07460871
16	Spliceosome_Homo sapiens_hsa03040	2.04478516
17	Nucleotide excision repair_Homo sapiens_hsa03420	2.00867194
18	One carbon pool by folate_Homo sapiens_hsa00670	1.99093783
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.95176690
20	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.94918208
21	Homologous recombination_Homo sapiens_hsa03440	1.90127608
22	Pyruvate metabolism_Homo sapiens_hsa00620	1.87106593
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.84729101
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.81809865
25	Carbon metabolism_Homo sapiens_hsa01200	1.79365079
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.79093533
27	RNA polymerase_Homo sapiens_hsa03020	1.71283634
28	RNA transport_Homo sapiens_hsa03013	1.69860771
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.69398997
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.56567181
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.53339251
32	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.51612863
33	Fatty acid elongation_Homo sapiens_hsa00062	1.50613767
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.48342377
35	Huntingtons disease_Homo sapiens_hsa05016	1.45988864
36	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.43487296
37	Cell cycle_Homo sapiens_hsa04110	1.38531565
38	Sulfur relay system_Homo sapiens_hsa04122	1.37551209
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37540410
40	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.36064266
41	RNA degradation_Homo sapiens_hsa03018	1.32731142
42	Folate biosynthesis_Homo sapiens_hsa00790	1.32425829
43	Basal transcription factors_Homo sapiens_hsa03022	1.28243448
44	Alzheimers disease_Homo sapiens_hsa05010	1.22631458
45	Butanoate metabolism_Homo sapiens_hsa00650	1.11753113
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.09965679
47	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.09244960
48	Fatty acid metabolism_Homo sapiens_hsa01212	1.03906152
49	Selenocompound metabolism_Homo sapiens_hsa00450	1.03539270
50	Arginine and proline metabolism_Homo sapiens_hsa00330	1.02879313
51	Pentose phosphate pathway_Homo sapiens_hsa00030	1.02486707
52	Purine metabolism_Homo sapiens_hsa00230	1.01154169
53	Glutathione metabolism_Homo sapiens_hsa00480	0.98435650
54	mRNA surveillance pathway_Homo sapiens_hsa03015	0.94311405
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92978360
56	Arginine biosynthesis_Homo sapiens_hsa00220	0.89242298
57	Peroxisome_Homo sapiens_hsa04146	0.87136559
58	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.85242548
59	Metabolic pathways_Homo sapiens_hsa01100	0.82912059
60	Oocyte meiosis_Homo sapiens_hsa04114	0.78556737
61	Phenylalanine metabolism_Homo sapiens_hsa00360	0.78126474
62	Fatty acid degradation_Homo sapiens_hsa00071	0.76044837
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72601509
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.71135942
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.70468061
66	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.65407758
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65230453
68	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.61228466
69	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.56247363
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51992539
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.51023796
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.50328620
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.47499855
74	Nitrogen metabolism_Homo sapiens_hsa00910	0.45942010
75	Galactose metabolism_Homo sapiens_hsa00052	0.44972664
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.44461452
77	p53 signaling pathway_Homo sapiens_hsa04115	0.44238017
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44207785
79	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.41868644
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41763530
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38392294
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.37729155
83	Retinol metabolism_Homo sapiens_hsa00830	0.36909337
84	Sulfur metabolism_Homo sapiens_hsa00920	0.35965050
85	Caffeine metabolism_Homo sapiens_hsa00232	0.32968667
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.30388611
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.29845593
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.26971087
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26961847
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26799286
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.26722473
92	Lysine degradation_Homo sapiens_hsa00310	0.24886132
93	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.21624530
94	Thyroid cancer_Homo sapiens_hsa05216	0.20482327
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.20379351
96	Vibrio cholerae infection_Homo sapiens_hsa05110	0.18543243
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.17555180
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.17479518
99	Alcoholism_Homo sapiens_hsa05034	0.17009433
100	Regulation of autophagy_Homo sapiens_hsa04140	0.14334156

GCSHP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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