GDA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)5.36612558
2vocalization behavior (GO:0071625)4.99198458
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.79427921
4synaptic vesicle exocytosis (GO:0016079)4.77516493
5urea metabolic process (GO:0019627)4.55388321
6urea cycle (GO:0000050)4.52774097
7regulation of guanylate cyclase activity (GO:0031282)4.51261929
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.39815380
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.36772595
10glutamate secretion (GO:0014047)4.24507511
11proline transport (GO:0015824)4.23288162
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.21832802
13nitrogen cycle metabolic process (GO:0071941)4.17594503
14locomotory exploration behavior (GO:0035641)4.16773794
15regulation of glutamate receptor signaling pathway (GO:1900449)4.16294415
16regulation of bile acid biosynthetic process (GO:0070857)4.12136799
17synaptic vesicle maturation (GO:0016188)4.12042973
18cellular glucuronidation (GO:0052695)4.11372528
19response to histamine (GO:0034776)4.08826143
20protein localization to synapse (GO:0035418)4.06170565
21peptide hormone processing (GO:0016486)4.03621805
22NADH metabolic process (GO:0006734)4.01632445
23glucuronate metabolic process (GO:0019585)3.99768720
24uronic acid metabolic process (GO:0006063)3.99768720
25drug metabolic process (GO:0017144)3.97744578
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.96877552
27regulation of synaptic vesicle exocytosis (GO:2000300)3.95955974
28regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.94940487
29G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.88233445
30exogenous drug catabolic process (GO:0042738)3.86725894
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.84631941
32drug catabolic process (GO:0042737)3.83528227
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.75538370
34glutamate receptor signaling pathway (GO:0007215)3.71251996
35positive regulation of guanylate cyclase activity (GO:0031284)3.68734171
36angiotensin maturation (GO:0002003)3.67006461
37regulation of synaptic vesicle transport (GO:1902803)3.61044451
38flavonoid metabolic process (GO:0009812)3.60268731
39neuron cell-cell adhesion (GO:0007158)3.60055829
40exploration behavior (GO:0035640)3.59243027
41neurotransmitter secretion (GO:0007269)3.56118112
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.55709122
43negative regulation of cell killing (GO:0031342)3.47624034
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.47624034
45homocysteine metabolic process (GO:0050667)3.46070841
46layer formation in cerebral cortex (GO:0021819)3.44416723
47lipoprotein transport (GO:0042953)3.42810586
48regulation of neuronal synaptic plasticity (GO:0048168)3.41703146
49bile acid and bile salt transport (GO:0015721)3.36177439
50synaptic vesicle docking involved in exocytosis (GO:0016081)3.35953623
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34501795
52neuronal action potential propagation (GO:0019227)3.33413494
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.29098666
54fat-soluble vitamin biosynthetic process (GO:0042362)3.28683433
55glutamine family amino acid biosynthetic process (GO:0009084)3.23512526
56synaptic vesicle endocytosis (GO:0048488)3.21044466
57neuron-neuron synaptic transmission (GO:0007270)3.20687067
58cellular ketone body metabolic process (GO:0046950)3.19498736
59cellular potassium ion homeostasis (GO:0030007)3.16645813
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.16160625
61L-phenylalanine metabolic process (GO:0006558)3.16160625
62regulation of postsynaptic membrane potential (GO:0060078)3.16049794
63arginine metabolic process (GO:0006525)3.15033424
64hormone catabolic process (GO:0042447)3.14687119
65fructose metabolic process (GO:0006000)3.14344427
66dendritic spine morphogenesis (GO:0060997)3.14100406
67regulation of synapse structural plasticity (GO:0051823)3.13697382
68synaptic transmission, glutamatergic (GO:0035249)3.11632160
69regulation of cGMP biosynthetic process (GO:0030826)3.11526774
70heme transport (GO:0015886)3.11413988
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.11293509
72L-phenylalanine catabolic process (GO:0006559)3.11293509
73neuron recognition (GO:0008038)3.09747423
74long-term memory (GO:0007616)3.08290197
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07908352
76neurotransmitter transport (GO:0006836)3.07219914
77midgut development (GO:0007494)3.06874410
78regulation of vesicle fusion (GO:0031338)3.06347986
79neurotransmitter-gated ion channel clustering (GO:0072578)3.04792618
80long-term synaptic potentiation (GO:0060291)3.02656682
81phenylpropanoid metabolic process (GO:0009698)3.01780561
82negative regulation of hormone metabolic process (GO:0032351)3.01295540
83iron coordination entity transport (GO:1901678)3.00512604
84regulation of dendritic spine morphogenesis (GO:0061001)2.99431354
85regulation of synaptic plasticity (GO:0048167)2.98599565
86citrulline biosynthetic process (GO:0019240)2.97058993
87positive regulation of membrane potential (GO:0045838)2.96192514
88omega-hydroxylase P450 pathway (GO:0097267)2.95261006
89positive regulation of neurotransmitter secretion (GO:0001956)2.94553828
90activation of protein kinase A activity (GO:0034199)2.94002640
91regulation of glutamate secretion (GO:0014048)2.93907389
92gamma-aminobutyric acid transport (GO:0015812)2.93133254
93very-low-density lipoprotein particle assembly (GO:0034379)2.92130675
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92056330
95intestinal absorption (GO:0050892)2.91986991
96bile acid metabolic process (GO:0008206)2.91133671
97regulation of triglyceride catabolic process (GO:0010896)2.90718651
98serotonin metabolic process (GO:0042428)2.90243910
99potassium ion homeostasis (GO:0055075)2.90205765
100fear response (GO:0042596)2.87280663
101positive regulation of vesicle fusion (GO:0031340)2.87108204
102phosphate ion transmembrane transport (GO:0035435)2.86168095
103digestion (GO:0007586)2.83191310
104negative regulation of dendrite morphogenesis (GO:0050774)2.82544556
105sodium ion homeostasis (GO:0055078)2.82491244
106regulation of neurotransmitter secretion (GO:0046928)2.82376673
107vitamin transport (GO:0051180)2.82280911
108primary amino compound metabolic process (GO:1901160)2.80681527
109regulation of dendritic spine development (GO:0060998)2.80315712
110positive regulation of neurotransmitter transport (GO:0051590)2.77712688
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.77303323
112regulation of neurotransmitter levels (GO:0001505)2.76790951
113auditory receptor cell differentiation (GO:0042491)2.75870255
114vesicle transport along microtubule (GO:0047496)2.75869471
115drug transmembrane transport (GO:0006855)2.74917934
116ketone body metabolic process (GO:1902224)2.74218657
117nucleoside diphosphate biosynthetic process (GO:0009133)2.72843725
118regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.71920607
119endocrine process (GO:0050886)2.71920607
120regulation of systemic arterial blood pressure by hormone (GO:0001990)2.71920607
121behavioral defense response (GO:0002209)2.71754741
122behavioral fear response (GO:0001662)2.71754741
123sodium ion export (GO:0071436)2.70385208
124regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.67799861
125presynaptic membrane assembly (GO:0097105)2.67497148
126ethanol oxidation (GO:0006069)2.65870817
127L-amino acid import (GO:0043092)2.65420383
128neutral amino acid transport (GO:0015804)2.65299667
129receptor guanylyl cyclase signaling pathway (GO:0007168)2.65220344
130axonal fasciculation (GO:0007413)2.64699967
131alkaloid metabolic process (GO:0009820)2.64348993
132potassium ion import (GO:0010107)2.62885568
133detection of calcium ion (GO:0005513)2.62852104
134positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.62678609
135intestinal cholesterol absorption (GO:0030299)2.62506156
136phagosome maturation (GO:0090382)2.62445485
137vitamin biosynthetic process (GO:0009110)2.60498892
138glycine transport (GO:0015816)2.60237226
139negative regulation of hormone biosynthetic process (GO:0032353)2.59889769
140regulation of amyloid precursor protein catabolic process (GO:1902991)2.59811950
141behavioral response to cocaine (GO:0048148)2.59516197
1423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.59222062
143purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.59222062
144C4-dicarboxylate transport (GO:0015740)2.58993719
145urate metabolic process (GO:0046415)2.58077048
146regulation of neurotransmitter transport (GO:0051588)2.57653707
147diacylglycerol metabolic process (GO:0046339)2.57619628
148negative regulation of amino acid transport (GO:0051956)2.57588324
149positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57522663
150long term synaptic depression (GO:0060292)2.57357466
151citrulline metabolic process (GO:0000052)2.57243748
152mating behavior (GO:0007617)2.56306830
153energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.56128370
154ATP hydrolysis coupled proton transport (GO:0015991)2.56128370
155cellular sodium ion homeostasis (GO:0006883)2.55431496
156positive regulation of synapse maturation (GO:0090129)2.53840837
157regulation of systemic arterial blood pressure (GO:0003073)2.53800075
158myelin maintenance (GO:0043217)2.53506420
159positive regulation of cGMP biosynthetic process (GO:0030828)2.53330080
160protein targeting to Golgi (GO:0000042)2.53026765
161cellular response to ammonium ion (GO:0071242)2.52822029
162drinking behavior (GO:0042756)2.52480261
163G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51598678
164oxaloacetate metabolic process (GO:0006107)2.51407485
165positive regulation of glycolytic process (GO:0045821)2.50835539
166phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.50509523
167membrane depolarization (GO:0051899)2.49141836
168regulation of cGMP metabolic process (GO:0030823)2.49053338
169regulation of exocytosis (GO:0017157)2.47587629
170synaptic transmission (GO:0007268)2.47477270
171regulation of protein kinase A signaling (GO:0010738)2.47430479
172positive regulation of synaptic transmission (GO:0050806)2.47118759
173membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46758741
174clathrin coat assembly (GO:0048268)2.46539392
175regulation of synaptic transmission (GO:0050804)2.45977663
176positive regulation of dendritic spine development (GO:0060999)2.45563173
177establishment of synaptic vesicle localization (GO:0097480)2.44935304
178synaptic vesicle transport (GO:0048489)2.44935304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.97329558
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.17418250
3GBX2_23144817_ChIP-Seq_PC3_Human3.11800701
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84859201
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75661701
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67545935
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52893885
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51196038
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.38454518
10REST_21632747_ChIP-Seq_MESCs_Mouse2.30829625
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30201715
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30201715
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27930703
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27280154
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24345366
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22288897
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21299722
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15745635
19TAF15_26573619_Chip-Seq_HEK293_Human2.14854128
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.13993951
21DROSHA_22980978_ChIP-Seq_HELA_Human2.13935841
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05863199
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97049967
24RXR_22158963_ChIP-Seq_LIVER_Mouse1.92941147
25* LXR_22158963_ChIP-Seq_LIVER_Mouse1.86963666
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.86160548
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81730143
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.79763433
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78586062
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.77027504
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76998128
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74083800
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.73552870
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.70135968
35GATA4_25053715_ChIP-Seq_YYC3_Human1.69132926
36* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68964493
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.65900177
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.65299637
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.63657516
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.57119589
41* SOX2_20726797_ChIP-Seq_SW620_Human1.55758433
42TP53_16413492_ChIP-PET_HCT116_Human1.53960830
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.53925644
44AR_21572438_ChIP-Seq_LNCaP_Human1.53585051
45P300_19829295_ChIP-Seq_ESCs_Human1.49483225
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49349492
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48551521
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47784646
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47779021
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45747684
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44787146
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.36035185
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.34298207
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34253653
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33527377
56* AR_25329375_ChIP-Seq_VCAP_Human1.33003842
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.32831463
58GATA1_22025678_ChIP-Seq_K562_Human1.32778346
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32291125
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26768284
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25774988
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25335952
63GATA6_25053715_ChIP-Seq_YYC3_Human1.24765487
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24438325
65CDX2_22108803_ChIP-Seq_LS180_Human1.23980221
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23734825
67FOXA1_25552417_ChIP-Seq_VCAP_Human1.23406586
68HTT_18923047_ChIP-ChIP_STHdh_Human1.23069276
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22861096
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22745473
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21834417
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.20960498
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20558166
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.20555404
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19290916
76* HNF4A_19822575_ChIP-Seq_HepG2_Human1.19115960
77VDR_22108803_ChIP-Seq_LS180_Human1.19065694
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.16276332
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15498770
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15477569
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15302092
82* PRDM14_20953172_ChIP-Seq_ESCs_Human1.14494608
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13964415
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13247839
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12838750
86BCAT_22108803_ChIP-Seq_LS180_Human1.12156213
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10555343
88* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10477285
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09688575
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09391826
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08254260
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08242438
93STAT3_23295773_ChIP-Seq_U87_Human1.07417214
94TP53_18474530_ChIP-ChIP_U2OS_Human1.07317211
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07052184
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06817635
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05852773
98* TCF4_22108803_ChIP-Seq_LS180_Human1.05445080
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05339655
100CBP_21632823_ChIP-Seq_H3396_Human1.05272578
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.03444384
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.03443297
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02276025
104* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02019281
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.00642068
106PHF8_20622853_ChIP-Seq_HELA_Human0.99366124
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.99299213
108FUS_26573619_Chip-Seq_HEK293_Human0.99211009
109SOX2_18555785_Chip-Seq_ESCs_Mouse0.98862338
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97813285
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97805843
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97804840
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.97415137
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97033657
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96985304
116ZNF274_21170338_ChIP-Seq_K562_Hela0.96598845
117FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96304620
118FOXA1_25329375_ChIP-Seq_VCAP_Human0.96304620
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94831948
120* TCF4_23295773_ChIP-Seq_U87_Human0.94720910
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94239528
122P53_22387025_ChIP-Seq_ESCs_Mouse0.93637845
123TBL1_22424771_ChIP-Seq_293T_Human0.93528167
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.93522984
125AR_19668381_ChIP-Seq_PC3_Human0.93505319
126NCOR_22424771_ChIP-Seq_293T_Human0.93218226
127CMYC_18555785_Chip-Seq_ESCs_Mouse0.92730352
128AHR_22903824_ChIP-Seq_MCF-7_Human0.92374975
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92128206
130NFYB_21822215_ChIP-Seq_K562_Human0.91496444
131JUN_21703547_ChIP-Seq_K562_Human0.91159351
132RUNX2_22187159_ChIP-Seq_PCA_Human0.91153472
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91090646
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91090646
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90927357
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90926383
137* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90726765
138BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90143730
139KDM2B_26808549_Chip-Seq_REH_Human0.89714333
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89315538
141RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88971698
142RXR_22108803_ChIP-Seq_LS180_Human0.88200519
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86814541
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83958008
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.83359469
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82688690
147NANOG_18555785_Chip-Seq_ESCs_Mouse0.81089107
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81011008

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.80692826
2MP0003880_abnormal_central_pattern4.57125612
3MP0002139_abnormal_hepatobiliary_system4.17927584
4MP0002822_catalepsy4.13549528
5MP0003635_abnormal_synaptic_transmissio3.73712550
6MP0004270_analgesia3.66064632
7MP0009745_abnormal_behavioral_response3.32979636
8MP0005365_abnormal_bile_salt3.13562755
9MP0002063_abnormal_learning/memory/cond3.06411922
10MP0004019_abnormal_vitamin_homeostasis2.97858234
11MP0001968_abnormal_touch/_nociception2.94619869
12MP0002064_seizures2.87619546
13MP0001501_abnormal_sleep_pattern2.64941185
14MP0005360_urolithiasis2.63334653
15MP0002572_abnormal_emotion/affect_behav2.60176042
16MP0001440_abnormal_grooming_behavior2.54202703
17MP0003329_amyloid_beta_deposits2.53950488
18MP0002736_abnormal_nociception_after2.47450397
19MP0002734_abnormal_mechanical_nocicepti2.37876780
20MP0009046_muscle_twitch2.30104265
21MP0005332_abnormal_amino_acid2.29900992
22MP0002735_abnormal_chemical_nociception2.12293133
23MP0003195_calcinosis2.06119126
24MP0002733_abnormal_thermal_nociception2.05631083
25MP0002272_abnormal_nervous_system2.04093782
26MP0001970_abnormal_pain_threshold1.98635146
27MP0001486_abnormal_startle_reflex1.98298094
28MP0003183_abnormal_peptide_metabolism1.94126677
29MP0000604_amyloidosis1.90948700
30MP0009780_abnormal_chondrocyte_physiolo1.90352698
31MP0010234_abnormal_vibrissa_follicle1.89938833
32MP0002837_dystrophic_cardiac_calcinosis1.77726218
33MP0004924_abnormal_behavior1.74382426
34MP0005386_behavior/neurological_phenoty1.74382426
35MP0003252_abnormal_bile_duct1.71842314
36MP0003868_abnormal_feces_composition1.66057676
37MP0002876_abnormal_thyroid_physiology1.62195161
38MP0004858_abnormal_nervous_system1.60446940
39MP0003879_abnormal_hair_cell1.58757095
40MP0002067_abnormal_sensory_capabilities1.55553780
41MP0001529_abnormal_vocalization1.52935285
42MP0010386_abnormal_urinary_bladder1.51350538
43MP0003075_altered_response_to1.49852574
44MP0001666_abnormal_nutrient_absorption1.45050377
45MP0004043_abnormal_pH_regulation1.42768596
46MP0005636_abnormal_mineral_homeostasis1.42729799
47MP0003303_peritoneal_inflammation1.42703242
48MP0008874_decreased_physiological_sensi1.40416658
49MP0005423_abnormal_somatic_nervous1.40109885
50MP0008872_abnormal_physiological_respon1.40063262
51MP0006276_abnormal_autonomic_nervous1.39433575
52MP0009643_abnormal_urine_homeostasis1.38514769
53MP0003633_abnormal_nervous_system1.37580765
54MP0001905_abnormal_dopamine_level1.34520112
55MP0004510_myositis1.33993041
56MP0005535_abnormal_body_temperature1.32933022
57MP0004264_abnormal_extraembryonic_tissu1.32234109
58MP0002909_abnormal_adrenal_gland1.31269928
59MP0002118_abnormal_lipid_homeostasis1.29465986
60MP0002557_abnormal_social/conspecific_i1.27873363
61MP0001764_abnormal_homeostasis1.26367383
62MP0005167_abnormal_blood-brain_barrier1.26150159
63MP0004811_abnormal_neuron_physiology1.25405281
64MP0008569_lethality_at_weaning1.23863265
65MP0003787_abnormal_imprinting1.22130681
66MP0010329_abnormal_lipoprotein_level1.16216281
67MP0001756_abnormal_urination1.13440258
68MP0005166_decreased_susceptibility_to1.08509276
69MP0003631_nervous_system_phenotype1.08208906
70MP0000778_abnormal_nervous_system1.07939806
71MP0008875_abnormal_xenobiotic_pharmacok1.07861328
72MP0002066_abnormal_motor_capabilities/c1.05755527
73MP0002184_abnormal_innervation1.04572051
74MP0002638_abnormal_pupillary_reflex1.04006766
75MP0002078_abnormal_glucose_homeostasis1.03002650
76MP0001664_abnormal_digestion1.01892330
77MP0001485_abnormal_pinna_reflex0.96354438
78MP0000003_abnormal_adipose_tissue0.95729903
79MP0004484_altered_response_of0.95237718
80MP0005551_abnormal_eye_electrophysiolog0.94706820
81MP0010678_abnormal_skin_adnexa0.94060074
82MP0002693_abnormal_pancreas_physiology0.92713385
83MP0003953_abnormal_hormone_level0.91660789
84MP0001944_abnormal_pancreas_morphology0.91471598
85MP0000955_abnormal_spinal_cord0.90454008
86MP0005448_abnormal_energy_balance0.89062420
87MP0002971_abnormal_brown_adipose0.87910207
88MP0005310_abnormal_salivary_gland0.87463001
89MP0005379_endocrine/exocrine_gland_phen0.87428135
90MP0001188_hyperpigmentation0.86974289
91MP0003690_abnormal_glial_cell0.86715402
92MP0002254_reproductive_system_inflammat0.85607979
93MP0000538_abnormal_urinary_bladder0.84996255
94MP0005409_darkened_coat_color0.84317818
95MP0001984_abnormal_olfaction0.84248549
96MP0005085_abnormal_gallbladder_physiolo0.84219968
97MP0002069_abnormal_eating/drinking_beha0.84135364
98MP0003718_maternal_effect0.83478247
99MP0009840_abnormal_foam_cell0.81467355
100MP0002138_abnormal_hepatobiliary_system0.81381279
101MP0001663_abnormal_digestive_system0.80593679
102MP0002882_abnormal_neuron_morphology0.80372794
103MP0010352_gastrointestinal_tract_polyps0.80015759
104MP0003283_abnormal_digestive_organ0.79561386
105MP0005584_abnormal_enzyme/coenzyme_acti0.78698521
106MP0004147_increased_porphyrin_level0.76182170
107MP0005646_abnormal_pituitary_gland0.75819966
108MP0000569_abnormal_digit_pigmentation0.75191479
109MP0001502_abnormal_circadian_rhythm0.74889305
110MP0002136_abnormal_kidney_physiology0.74136897
111MP0000230_abnormal_systemic_arterial0.71880822
112MP0000609_abnormal_liver_physiology0.70577106
113MP0000462_abnormal_digestive_system0.69463839
114MP0005645_abnormal_hypothalamus_physiol0.69404097
115MP0004883_abnormal_blood_vessel0.69044464
116MP0000013_abnormal_adipose_tissue0.68415037
117MP0002090_abnormal_vision0.68140250
118MP0005174_abnormal_tail_pigmentation0.66920776
119MP0001177_atelectasis0.66130730
120MP0004142_abnormal_muscle_tone0.63503642
121MP0002229_neurodegeneration0.63044353
122MP0003638_abnormal_response/metabolism_0.62460649
123MP0003436_decreased_susceptibility_to0.61831707
124MP0005464_abnormal_platelet_physiology0.61750404
125MP0003632_abnormal_nervous_system0.59943231
126MP0003656_abnormal_erythrocyte_physiolo0.59513817
127MP0004130_abnormal_muscle_cell0.58657801
128MP0003172_abnormal_lysosome_physiology0.58594760
129MP0002152_abnormal_brain_morphology0.58462746
130MP0004085_abnormal_heartbeat0.58371825
131MP0003191_abnormal_cellular_cholesterol0.58042096
132MP0001765_abnormal_ion_homeostasis0.57650875
133MP0003866_abnormal_defecation0.56620381
134MP0009379_abnormal_foot_pigmentation0.55607652
135MP0004885_abnormal_endolymph0.54854226
136MP0005381_digestive/alimentary_phenotyp0.54463895

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.59863571
2Myokymia (HP:0002411)5.53886685
3Focal seizures (HP:0007359)5.51398336
4Visual hallucinations (HP:0002367)5.46055216
5Hydroxyprolinuria (HP:0003080)4.98060229
6Abnormality of proline metabolism (HP:0010907)4.98060229
7Atonic seizures (HP:0010819)4.53082631
8Epileptic encephalopathy (HP:0200134)4.31951409
9Absence seizures (HP:0002121)4.27966232
10Cerebral inclusion bodies (HP:0100314)4.17940822
11Febrile seizures (HP:0002373)4.08156099
12Abnormality of vitamin B metabolism (HP:0004340)4.05503179
13Generalized tonic-clonic seizures (HP:0002069)4.04535349
14Hyperventilation (HP:0002883)3.94619172
15Malnutrition (HP:0004395)3.91616476
16Dialeptic seizures (HP:0011146)3.88289925
17Papilledema (HP:0001085)3.85278458
18Abnormality of vitamin metabolism (HP:0100508)3.70744976
19Abnormality of the vitamin B12 metabolism (HP:0004341)3.62564387
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.55884917
21Supranuclear gaze palsy (HP:0000605)3.48676808
22Neurofibrillary tangles (HP:0002185)3.47742710
23Confusion (HP:0001289)3.47355814
24Amblyopia (HP:0000646)3.47102799
25Alkalosis (HP:0001948)3.43257688
26Fat malabsorption (HP:0002630)3.42465955
27Abnormality of monocarboxylic acid metabolism (HP:0010996)3.35669190
28Poor eye contact (HP:0000817)3.33491960
29Glycosuria (HP:0003076)3.31185457
30Abnormality of urine glucose concentration (HP:0011016)3.31185457
31Impaired social interactions (HP:0000735)3.27677182
32Abnormal social behavior (HP:0012433)3.27677182
33Broad-based gait (HP:0002136)3.21677639
34Hypoglycemic coma (HP:0001325)3.16297867
35Increased circulating renin level (HP:0000848)3.02557559
36Ketoacidosis (HP:0001993)3.01609712
37Mutism (HP:0002300)2.95870583
38Metabolic alkalosis (HP:0200114)2.95100606
39Progressive cerebellar ataxia (HP:0002073)2.93316632
40Abnormal eating behavior (HP:0100738)2.90241134
41Hyperammonemia (HP:0001987)2.88106914
42Proximal tubulopathy (HP:0000114)2.83008304
43Hyperglycinuria (HP:0003108)2.80946397
44Acanthocytosis (HP:0001927)2.80260838
45Abnormality of renin-angiotensin system (HP:0000847)2.77427576
46Anxiety (HP:0000739)2.74615156
47Congenital sensorineural hearing impairment (HP:0008527)2.72550586
48Progressive inability to walk (HP:0002505)2.70019633
49Hypoglycemic seizures (HP:0002173)2.67793450
50Abnormality of magnesium homeostasis (HP:0004921)2.66615078
51Inability to walk (HP:0002540)2.66612608
52Hyperglycemia (HP:0003074)2.66144804
53Dysmetria (HP:0001310)2.64961706
54Chronic diarrhea (HP:0002028)2.62792497
55Hypolipoproteinemia (HP:0010981)2.62502639
56Truncal ataxia (HP:0002078)2.62041920
57Excessive salivation (HP:0003781)2.61293364
58Drooling (HP:0002307)2.61293364
59Diplopia (HP:0000651)2.60767358
60Abnormality of binocular vision (HP:0011514)2.60767358
61Hyperinsulinemic hypoglycemia (HP:0000825)2.60069880
62Urinary bladder sphincter dysfunction (HP:0002839)2.59457281
63Xanthomatosis (HP:0000991)2.57134500
64Action tremor (HP:0002345)2.56141951
65Depression (HP:0000716)2.55725066
66Steatorrhea (HP:0002570)2.54985171
67Polyphagia (HP:0002591)2.51790574
68Widely patent fontanelles and sutures (HP:0004492)2.51734222
69Pigmentary retinal degeneration (HP:0001146)2.51604376
70Abnormality of glycine metabolism (HP:0010895)2.49850530
71Abnormality of serine family amino acid metabolism (HP:0010894)2.49850530
72Insidious onset (HP:0003587)2.49587959
73Termporal pattern (HP:0011008)2.49587959
74Inappropriate behavior (HP:0000719)2.48595231
75Gaze-evoked nystagmus (HP:0000640)2.48127270
76Stereotypic behavior (HP:0000733)2.45946176
77Decreased circulating renin level (HP:0003351)2.44166945
78Systemic lupus erythematosus (HP:0002725)2.43131956
79Dysdiadochokinesis (HP:0002075)2.42977153
80Gout (HP:0001997)2.42833982
81Generalized myoclonic seizures (HP:0002123)2.40302250
82Postural instability (HP:0002172)2.39554462
83Recurrent gram-negative bacterial infections (HP:0005420)2.39413059
84Irritability (HP:0000737)2.39055088
85Impaired vibration sensation in the lower limbs (HP:0002166)2.37937401
86Psychosis (HP:0000709)2.36939604
87Absent speech (HP:0001344)2.34203003
88Hyperuricemia (HP:0002149)2.33678581
89Increased purine levels (HP:0004368)2.33678581
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32459347
91Ketosis (HP:0001946)2.30738925
92Conjugated hyperbilirubinemia (HP:0002908)2.29963440
93Exotropia (HP:0000577)2.29272323
94Hypomagnesemia (HP:0002917)2.29267056
95Eczematoid dermatitis (HP:0000976)2.29094970
96Delusions (HP:0000746)2.28610675
97Global brain atrophy (HP:0002283)2.27758665
98Symptomatic seizures (HP:0011145)2.25373532
99Ileus (HP:0002595)2.24423899
100Megaloblastic anemia (HP:0001889)2.23158851
101Late onset (HP:0003584)2.21334866
102Generalized hypopigmentation of hair (HP:0011358)2.20332210
103Abnormal gallbladder physiology (HP:0012438)2.19728768
104Cholecystitis (HP:0001082)2.19728768
105Epileptiform EEG discharges (HP:0011182)2.19727279
106Amyloidosis (HP:0011034)2.16784413
107Hyperphosphaturia (HP:0003109)2.15919930
108Rapidly progressive (HP:0003678)2.14937752
109Metabolic acidosis (HP:0001942)2.14392018
110Hyperactive renin-angiotensin system (HP:0000841)2.12880965
111Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12204164
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11510829
113Fair hair (HP:0002286)2.11038735
114Apathy (HP:0000741)2.10751452
115Nephrolithiasis (HP:0000787)2.09385992
116Abdominal distention (HP:0003270)2.09374407
117Impaired smooth pursuit (HP:0007772)2.09178518
118Abnormality of purine metabolism (HP:0004352)2.08505895
119Akinesia (HP:0002304)2.07310790
120Bradykinesia (HP:0002067)2.06708036
121Dysmetric saccades (HP:0000641)2.06588221
122Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05947509
123Abnormal urine phosphate concentration (HP:0012599)2.05554085
124EEG with generalized epileptiform discharges (HP:0011198)2.02744349
125Status epilepticus (HP:0002133)2.02288341
126Limb dystonia (HP:0002451)2.01156215
127Abnormality of nucleobase metabolism (HP:0010932)2.00501999
128Epidermoid cyst (HP:0200040)1.99518891
129Autoimmune thrombocytopenia (HP:0001973)1.99312719
130Recurrent abscess formation (HP:0002722)1.98405713
131Vascular calcification (HP:0004934)1.97870516
132Recurrent bacterial skin infections (HP:0005406)1.97856702
133Neuronal loss in central nervous system (HP:0002529)1.97791590
134Abnormality of the corticospinal tract (HP:0002492)1.97576097
135Syncope (HP:0001279)1.96865624
136Lethargy (HP:0001254)1.96766078
137Torticollis (HP:0000473)1.96081369
138J-shaped sella turcica (HP:0002680)1.94896029
139Hypothermia (HP:0002045)1.94576618
140Diminished motivation (HP:0000745)1.92961507
141Cerebral hemorrhage (HP:0001342)1.92147112
142Poikilocytosis (HP:0004447)1.91207608
143Hyperphosphatemia (HP:0002905)1.91183067
144Clonus (HP:0002169)1.91093584
145Hypotension (HP:0002615)1.90752673
146Ankle clonus (HP:0011448)1.89121698
147Orthostatic hypotension (HP:0001278)1.88786626
148Urinary urgency (HP:0000012)1.87635032
149Focal dystonia (HP:0004373)1.86642225
150Gingivitis (HP:0000230)1.85887985
151Intention tremor (HP:0002080)1.85572993
152Abnormality of salivation (HP:0100755)1.85060100
153Facial shape deformation (HP:0011334)1.84824159
154Potter facies (HP:0002009)1.84824159
155Increased IgE level (HP:0003212)1.84147532
156Ventricular fibrillation (HP:0001663)1.83737588
157Focal segmental glomerulosclerosis (HP:0000097)1.83737349
158Hemiparesis (HP:0001269)1.83322798
159Lower limb amyotrophy (HP:0007210)1.83307773
160Abnormality of pyrimidine metabolism (HP:0004353)1.83038953
161Hypsarrhythmia (HP:0002521)1.82763574
162Hyperthyroidism (HP:0000836)1.81317374
163Blue irides (HP:0000635)1.79210940
164Abnormality of sulfur amino acid metabolism (HP:0004339)1.78595433
165Clumsiness (HP:0002312)1.78589170
166Posterior subcapsular cataract (HP:0007787)1.77514376
167Ankyloglossia (HP:0010296)1.77194635
168Postural tremor (HP:0002174)1.76642063
169Insulin-resistant diabetes mellitus (HP:0000831)1.76333450
170Hypobetalipoproteinemia (HP:0003563)1.75060804
171Cerebral edema (HP:0002181)1.74129853
172Scanning speech (HP:0002168)1.70374065
173Resting tremor (HP:0002322)1.69570477
174Protruding tongue (HP:0010808)1.69477782
175Lower limb asymmetry (HP:0100559)1.69294000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.43711305
2RIPK44.29040715
3EPHA44.11926912
4MAP3K93.89575325
5NTRK33.76112242
6MAP3K123.38368108
7PDK23.08982070
8STK392.89629898
9MAP3K42.79520896
10KSR22.68015699
11OXSR12.61863944
12DAPK22.61381625
13MAP2K72.38813833
14WNK42.30493829
15MAP2K42.24275328
16MINK12.19943771
17NTRK12.08500667
18GRK62.07219820
19GRK52.06288126
20MAP3K132.05083065
21ARAF2.03480282
22DAPK11.88063646
23FRK1.83624931
24PLK21.79254432
25MARK11.78421144
26FES1.76359405
27FGR1.74139848
28MAP3K21.73442563
29PNCK1.65279307
30MET1.62245968
31PINK11.62136557
32EPHA21.61038839
33PHKG11.55138911
34PHKG21.55138911
35NME11.51907066
36SIK21.50264014
37PTK2B1.45803928
38KSR11.45725151
39CAMKK11.40736920
40UHMK11.36509697
41NEK61.36262698
42BMPR21.34614046
43CASK1.34289454
44PAK61.33592431
45GRK71.29483223
46CDK51.28091681
47RAF11.26614383
48NTRK21.24169305
49MST1R1.18003673
50MAP3K61.13398997
51GRK10.96712927
52CAMK1G0.95738973
53FGFR20.95421266
54CDK190.94131213
55CAMK2A0.91902546
56CAMKK20.90313260
57FGFR30.89896854
58MAP3K10.88408791
59TNIK0.85897431
60RIPK10.83523633
61PDPK10.83255521
62PRKCG0.80546829
63TAOK10.78267238
64STK110.76567975
65RET0.75923809
66MATK0.75475729
67MAP2K10.75425079
68CAMK2G0.74959477
69LMTK20.73949412
70PDK10.72580189
71PRKCI0.71850604
72STK380.70211811
73LATS20.68558471
74MAP4K20.60882186
75MST40.60708417
76PRKCE0.59889706
77SGK10.57762591
78ADRBK20.57559140
79MAPK110.57439848
80CAMK10.57070266
81CAMK2B0.56948545
82BMPR1B0.55780500
83FYN0.55318964
84INSRR0.54771716
85ALK0.54050614
86MOS0.53869267
87NEK10.53380110
88SYK0.53074495
89MAPK130.52708840
90CSNK1G20.50692837
91CDK140.50604669
92TRPM70.49701841
93BRSK10.49186450
94CDK180.49150819
95CDK150.47747282
96AKT30.46644160
97MAPKAPK50.44921159
98FER0.43488505
99MAP3K70.43188875
100PRKCZ0.42395957
101PRKACG0.42229004
102PRKAA20.41216698
103MAPK120.41155404
104WNK10.40497277
105ERN10.39596505
106PRPF4B0.39551311
107CAMK1D0.39453484
108CDK11A0.39224263
109PRKACA0.39165168
110PIK3CA0.38537829
111DYRK1A0.38301578
112PAK30.38284410
113CAMK2D0.37618317
114TNK20.37435840
115PRKCH0.36896187
116CSNK1E0.36844540
117CSNK1A10.36716478
118TYRO30.35926726
119DAPK30.35874647
120RPS6KA20.35867534
121CCNB10.35649467
122SCYL20.35237791
123PRKAA10.34657193
124MAP2K20.34130384
125EPHA30.33246403
126AKT20.33102140
127PRKD30.32953197
128MAP3K50.32286805
129ERBB30.32090368
130PRKCQ0.31859801
131BMX0.31827379
132MAP2K60.31157593
133ABL20.30998466
134ERBB20.30922736
135WNK30.30237098
136JAK20.29207583
137DMPK0.28688061
138PRKCA0.26660924
139PRKCB0.26565797
140PRKG20.26351470
141BLK0.26084214
142SGK4940.26004412
143SGK2230.26004412
144RPS6KA30.25442473

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.09103099
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.93943664
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.77103966
4Synaptic vesicle cycle_Homo sapiens_hsa047212.68092916
5Long-term potentiation_Homo sapiens_hsa047202.58607637
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50101873
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41489292
8Olfactory transduction_Homo sapiens_hsa047402.35767586
9Circadian entrainment_Homo sapiens_hsa047132.18872807
10Amphetamine addiction_Homo sapiens_hsa050312.16372400
11Salivary secretion_Homo sapiens_hsa049702.13636499
12Glutamatergic synapse_Homo sapiens_hsa047242.09641466
13Renin secretion_Homo sapiens_hsa049242.06141629
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05821831
15GABAergic synapse_Homo sapiens_hsa047272.03266857
16Morphine addiction_Homo sapiens_hsa050322.03038181
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99240628
18Retinol metabolism_Homo sapiens_hsa008301.95266801
19Collecting duct acid secretion_Homo sapiens_hsa049661.92563529
20Dopaminergic synapse_Homo sapiens_hsa047281.84340416
21Chemical carcinogenesis_Homo sapiens_hsa052041.83002623
22Linoleic acid metabolism_Homo sapiens_hsa005911.82146456
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81395608
24Gastric acid secretion_Homo sapiens_hsa049711.75135453
25Vitamin B6 metabolism_Homo sapiens_hsa007501.72946803
26Sulfur metabolism_Homo sapiens_hsa009201.72825412
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66924969
28Long-term depression_Homo sapiens_hsa047301.62781134
29Serotonergic synapse_Homo sapiens_hsa047261.60877879
30Cholinergic synapse_Homo sapiens_hsa047251.60415278
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.55975944
32Butanoate metabolism_Homo sapiens_hsa006501.55130866
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.52931802
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50565665
35GnRH signaling pathway_Homo sapiens_hsa049121.47123221
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44826085
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44553226
38Taste transduction_Homo sapiens_hsa047421.43193878
39Oxytocin signaling pathway_Homo sapiens_hsa049211.42821524
40Tryptophan metabolism_Homo sapiens_hsa003801.40549533
41Arginine and proline metabolism_Homo sapiens_hsa003301.38752387
42Insulin secretion_Homo sapiens_hsa049111.38639707
43Fat digestion and absorption_Homo sapiens_hsa049751.37752606
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36469006
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.34458795
46Calcium signaling pathway_Homo sapiens_hsa040201.33190584
47Fatty acid degradation_Homo sapiens_hsa000711.30934070
48Phenylalanine metabolism_Homo sapiens_hsa003601.30675565
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29772059
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28305603
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26167958
52Mineral absorption_Homo sapiens_hsa049781.25568089
53Cocaine addiction_Homo sapiens_hsa050301.23769318
54Folate biosynthesis_Homo sapiens_hsa007901.21337605
55Protein digestion and absorption_Homo sapiens_hsa049741.19682693
56Caffeine metabolism_Homo sapiens_hsa002321.18227095
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17285152
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15713891
59Fructose and mannose metabolism_Homo sapiens_hsa000511.15337868
60Renin-angiotensin system_Homo sapiens_hsa046141.15294424
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14274015
62Gap junction_Homo sapiens_hsa045401.11040251
63PPAR signaling pathway_Homo sapiens_hsa033201.09610937
64Estrogen signaling pathway_Homo sapiens_hsa049151.06770814
65Vibrio cholerae infection_Homo sapiens_hsa051101.06280379
66African trypanosomiasis_Homo sapiens_hsa051431.03996979
67Bile secretion_Homo sapiens_hsa049761.03779470
68Arachidonic acid metabolism_Homo sapiens_hsa005901.02098419
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01492575
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01390034
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01297222
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01253586
73Type II diabetes mellitus_Homo sapiens_hsa049301.00798684
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99726312
75Ether lipid metabolism_Homo sapiens_hsa005650.99192153
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97642074
77cAMP signaling pathway_Homo sapiens_hsa040240.96528173
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.95173166
79Alzheimers disease_Homo sapiens_hsa050100.93015517
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92387828
81Glioma_Homo sapiens_hsa052140.89356360
82Thyroid hormone synthesis_Homo sapiens_hsa049180.84608976
83Dorso-ventral axis formation_Homo sapiens_hsa043200.84192262
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84094782
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81237388
86Pancreatic secretion_Homo sapiens_hsa049720.81191533
87ABC transporters_Homo sapiens_hsa020100.80760205
88VEGF signaling pathway_Homo sapiens_hsa043700.80329577
89Peroxisome_Homo sapiens_hsa041460.80217156
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77844197
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.77521584
92Melanogenesis_Homo sapiens_hsa049160.73490934
93Oxidative phosphorylation_Homo sapiens_hsa001900.72907761
94Starch and sucrose metabolism_Homo sapiens_hsa005000.72861791
95Tyrosine metabolism_Homo sapiens_hsa003500.71628842
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69282764
97Fatty acid metabolism_Homo sapiens_hsa012120.69196051
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68891932
99beta-Alanine metabolism_Homo sapiens_hsa004100.68099633
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67824034
101Sphingolipid metabolism_Homo sapiens_hsa006000.67450720
102Fatty acid biosynthesis_Homo sapiens_hsa000610.65775955
103Tuberculosis_Homo sapiens_hsa051520.61771583
104Propanoate metabolism_Homo sapiens_hsa006400.61577655
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61107280
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.60880600
107ErbB signaling pathway_Homo sapiens_hsa040120.60605528
108Pyruvate metabolism_Homo sapiens_hsa006200.59837904
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59147267
110Axon guidance_Homo sapiens_hsa043600.58884701
111Staphylococcus aureus infection_Homo sapiens_hsa051500.57967632
112Rheumatoid arthritis_Homo sapiens_hsa053230.57957567
113Cardiac muscle contraction_Homo sapiens_hsa042600.57179708
114Galactose metabolism_Homo sapiens_hsa000520.57101933
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56768272
116Choline metabolism in cancer_Homo sapiens_hsa052310.56659951
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.55870505
118Pertussis_Homo sapiens_hsa051330.55588396
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53994776
120Arginine biosynthesis_Homo sapiens_hsa002200.53927610
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53861294
122Phagosome_Homo sapiens_hsa041450.52192890
123Glycerolipid metabolism_Homo sapiens_hsa005610.51152319
124Vitamin digestion and absorption_Homo sapiens_hsa049770.50931154
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50001177
126Glucagon signaling pathway_Homo sapiens_hsa049220.49643117
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49421229
128Salmonella infection_Homo sapiens_hsa051320.47652596
129Chemokine signaling pathway_Homo sapiens_hsa040620.46911904
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.46898817
131Biosynthesis of amino acids_Homo sapiens_hsa012300.46393478
132Platelet activation_Homo sapiens_hsa046110.45688322
133Complement and coagulation cascades_Homo sapiens_hsa046100.44665130
134Prion diseases_Homo sapiens_hsa050200.42679989
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42457873
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41860533
137Histidine metabolism_Homo sapiens_hsa003400.40339660
138Carbon metabolism_Homo sapiens_hsa012000.39792341
139MAPK signaling pathway_Homo sapiens_hsa040100.39680724
140Parkinsons disease_Homo sapiens_hsa050120.39003631
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38552535
142Nitrogen metabolism_Homo sapiens_hsa009100.38331625
143* Metabolic pathways_Homo sapiens_hsa011000.37377436
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37109184
145Ovarian steroidogenesis_Homo sapiens_hsa049130.35835382
146Glutathione metabolism_Homo sapiens_hsa004800.35278805
147Osteoclast differentiation_Homo sapiens_hsa043800.35046538
148Oocyte meiosis_Homo sapiens_hsa041140.34777615
149Rap1 signaling pathway_Homo sapiens_hsa040150.33660286
150Inositol phosphate metabolism_Homo sapiens_hsa005620.33280425
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.30638824

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