GDAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ethanol (GO:0071361)6.04957558
2COPI coating of Golgi vesicle (GO:0048205)5.25441605
3Golgi transport vesicle coating (GO:0048200)5.25441605
4folic acid transport (GO:0015884)4.89906921
5autophagic vacuole assembly (GO:0000045)4.85208362
6folic acid metabolic process (GO:0046655)4.71891999
7purine nucleobase biosynthetic process (GO:0009113)4.71344676
8regulation of translation in response to stress (GO:0043555)4.57187399
9vitamin transmembrane transport (GO:0035461)4.57093294
10cellular response to leptin stimulus (GO:0044320)4.34792485
11neural tube formation (GO:0001841)4.31602856
12amino acid salvage (GO:0043102)4.29636679
13L-methionine salvage (GO:0071267)4.29636679
14L-methionine biosynthetic process (GO:0071265)4.29636679
15S-adenosylmethionine metabolic process (GO:0046500)4.24051861
16nucleobase biosynthetic process (GO:0046112)4.06767555
17amyloid precursor protein catabolic process (GO:0042987)3.99863970
18DNA double-strand break processing (GO:0000729)3.97886763
19GMP metabolic process (GO:0046037)3.96939431
20UDP-N-acetylglucosamine metabolic process (GO:0006047)3.85699233
21water-soluble vitamin biosynthetic process (GO:0042364)3.83812118
22DNA deamination (GO:0045006)3.78981144
23platelet dense granule organization (GO:0060155)3.78698878
24replication fork processing (GO:0031297)3.78396114
257-methylguanosine mRNA capping (GO:0006370)3.78081675
26negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.77467870
27protein prenylation (GO:0018342)3.71926298
28prenylation (GO:0097354)3.71926298
297-methylguanosine RNA capping (GO:0009452)3.65274351
30RNA capping (GO:0036260)3.65274351
31protein deneddylation (GO:0000338)3.65170962
32cullin deneddylation (GO:0010388)3.57181881
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.55811372
34termination of RNA polymerase III transcription (GO:0006386)3.55811372
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53193498
36response to leptin (GO:0044321)3.50612441
37cofactor transport (GO:0051181)3.48256666
38rRNA modification (GO:0000154)3.48051583
39microtubule anchoring (GO:0034453)3.45800663
40rRNA methylation (GO:0031167)3.42708725
41behavioral response to nicotine (GO:0035095)3.42162407
42cellular ketone body metabolic process (GO:0046950)3.39212134
43methionine metabolic process (GO:0006555)3.38742198
44pantothenate metabolic process (GO:0015939)3.38499372
45keratinocyte development (GO:0003334)3.37833505
46monoubiquitinated protein deubiquitination (GO:0035520)3.37239323
47serine family amino acid catabolic process (GO:0009071)3.36420630
48negative regulation of protein tyrosine kinase activity (GO:0061099)3.35696852
49protein K11-linked deubiquitination (GO:0035871)3.35182730
50negative regulation of fibroblast apoptotic process (GO:2000270)3.33551777
51response to pheromone (GO:0019236)3.32099674
52methionine biosynthetic process (GO:0009086)3.30216852
53establishment of protein localization to Golgi (GO:0072600)3.28676252
54regulation of glucokinase activity (GO:0033131)3.27877046
55regulation of hexokinase activity (GO:1903299)3.27877046
56COPII vesicle coating (GO:0048208)3.27357246
57RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.27017936
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25560370
59vitamin transport (GO:0051180)3.20245754
60ketone body metabolic process (GO:1902224)3.19341326
61kidney morphogenesis (GO:0060993)3.18718279
62L-fucose catabolic process (GO:0042355)3.17623157
63fucose catabolic process (GO:0019317)3.17623157
64L-fucose metabolic process (GO:0042354)3.17623157
65sulfur amino acid biosynthetic process (GO:0000097)3.15363044
66centriole replication (GO:0007099)3.14393256
67positive regulation of receptor recycling (GO:0001921)3.13999746
68regulation of spindle organization (GO:0090224)3.11284945
69NADH metabolic process (GO:0006734)3.10976830
70mitotic metaphase plate congression (GO:0007080)3.10186312
71regulation of meiosis I (GO:0060631)3.08450132
72endocrine pancreas development (GO:0031018)3.06108286
73protein maturation by protein folding (GO:0022417)3.04065432
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03462412
75regulation of mitotic spindle checkpoint (GO:1903504)3.03462412
76ribosome assembly (GO:0042255)3.03151320
77respiratory chain complex IV assembly (GO:0008535)3.00551683
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00141228
79negative regulation of translation, ncRNA-mediated (GO:0040033)3.00141228
80regulation of translation, ncRNA-mediated (GO:0045974)3.00141228
81recombinational repair (GO:0000725)2.98740755
82double-strand break repair via homologous recombination (GO:0000724)2.98611356
83protein K6-linked ubiquitination (GO:0085020)2.96442749
84protein targeting to Golgi (GO:0000042)2.95976694
85positive regulation of autophagy (GO:0010508)2.95818612
86resolution of meiotic recombination intermediates (GO:0000712)2.95329595
87protein localization to cilium (GO:0061512)2.92419032
88vacuole organization (GO:0007033)2.89546797
89photoreceptor cell maintenance (GO:0045494)2.89467629
90modified amino acid transport (GO:0072337)2.88147221
91oocyte maturation (GO:0001556)2.87666194
92synapsis (GO:0007129)2.87419905
93intestinal epithelial cell development (GO:0060576)2.83503963
94regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.83374479
95nucleotide-sugar biosynthetic process (GO:0009226)2.80022738
96positive regulation of mitotic sister chromatid separation (GO:1901970)2.79810595
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.79810595
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.79810595
99negative regulation of DNA-dependent DNA replication (GO:2000104)2.79734709
100indolalkylamine metabolic process (GO:0006586)2.79392403
101intraciliary transport (GO:0042073)2.78611125
102L-phenylalanine catabolic process (GO:0006559)2.77781041
103erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.77781041
104cilium morphogenesis (GO:0060271)2.77241484
105pyrimidine-containing compound transmembrane transport (GO:0072531)2.76747815
106maturation of 5.8S rRNA (GO:0000460)2.76705899
107signal peptide processing (GO:0006465)2.76341949
108type B pancreatic cell development (GO:0003323)2.76248846
109transcription elongation from RNA polymerase II promoter (GO:0006368)2.75912185
110chromatin remodeling at centromere (GO:0031055)2.75270846
111histone mRNA catabolic process (GO:0071044)2.74494300
112aromatic amino acid family catabolic process (GO:0009074)2.73240842
113peptidyl-histidine modification (GO:0018202)2.72761258
114cellular metabolic compound salvage (GO:0043094)2.72711260
115DNA-templated transcription, elongation (GO:0006354)2.71829323
116negative regulation of mast cell activation (GO:0033004)2.71778789
117axoneme assembly (GO:0035082)2.71518713
118negative regulation of transcription regulatory region DNA binding (GO:2000678)2.70784096
119intracellular pH reduction (GO:0051452)2.70318699
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70105430
121regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.69172384
122retrograde transport, vesicle recycling within Golgi (GO:0000301)2.68994494
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68971229
124preassembly of GPI anchor in ER membrane (GO:0016254)2.68928780
125vesicle targeting (GO:0006903)2.68376873
126microtubule organizing center organization (GO:0031023)2.67727682
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67148710
128histone H2A ubiquitination (GO:0033522)2.64610072
129beta-amyloid metabolic process (GO:0050435)2.64572170
130protein localization to Golgi apparatus (GO:0034067)2.63627218
131protein K11-linked ubiquitination (GO:0070979)2.63596482
132guanosine-containing compound biosynthetic process (GO:1901070)2.63368896
133prostate gland growth (GO:0060736)2.63236134
134glycine metabolic process (GO:0006544)2.63215301
135embryonic epithelial tube formation (GO:0001838)2.63038622
136nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62607083
137transcription elongation from RNA polymerase I promoter (GO:0006362)2.62559179
138skin morphogenesis (GO:0043589)2.62029736
139single strand break repair (GO:0000012)2.61811343
140regulation of centriole replication (GO:0046599)2.61569051
141protein K48-linked ubiquitination (GO:0070936)2.60358209
142urate metabolic process (GO:0046415)2.60119813
143positive regulation of mitochondrial fission (GO:0090141)2.59855619
144epithelial cilium movement (GO:0003351)2.59651744
145centrosome organization (GO:0051297)2.59633672
146sulfation (GO:0051923)2.59534454
147response to X-ray (GO:0010165)2.59135463
148kynurenine metabolic process (GO:0070189)2.58104344
149aromatic amino acid family metabolic process (GO:0009072)2.58096291
150maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58038793
151regulation of cilium movement (GO:0003352)2.57122869
152aspartate family amino acid biosynthetic process (GO:0009067)2.57049744
153regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.56308557
154magnesium ion transport (GO:0015693)2.56228431
155tryptophan metabolic process (GO:0006568)2.54602173
156protein polyglutamylation (GO:0018095)2.54310918
157somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.54163214
158isotype switching (GO:0045190)2.54163214
159somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.54163214
160inositol phosphate catabolic process (GO:0071545)2.53834137
161reciprocal DNA recombination (GO:0035825)2.53722995
162reciprocal meiotic recombination (GO:0007131)2.53722995
163behavioral response to ethanol (GO:0048149)2.53099293
164retinal cone cell development (GO:0046549)2.51611650
165cytochrome complex assembly (GO:0017004)2.51147523
166tryptophan catabolic process (GO:0006569)2.49942502
167indole-containing compound catabolic process (GO:0042436)2.49942502
168indolalkylamine catabolic process (GO:0046218)2.49942502
169positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.49516828
170DNA demethylation (GO:0080111)2.48076628
171regulation of helicase activity (GO:0051095)2.47996626
172negative regulation of DNA recombination (GO:0045910)2.47549605
173pH reduction (GO:0045851)2.46545758
174regulation of DNA endoreduplication (GO:0032875)2.45268980
175regulation of pigment cell differentiation (GO:0050932)2.45247569
176GPI anchor metabolic process (GO:0006505)2.45015975
177cilium organization (GO:0044782)2.44964812
178CENP-A containing nucleosome assembly (GO:0034080)2.44630307
179anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.44268028
180pyrimidine dimer repair (GO:0006290)2.43685869
181purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.43192593
1823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.43192593
183meiosis I (GO:0007127)2.43113571
184termination of RNA polymerase I transcription (GO:0006363)2.42995656
185regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.42804293
186endosome to melanosome transport (GO:0035646)2.42493368
187endosome to pigment granule transport (GO:0043485)2.42493368
188cornea development in camera-type eye (GO:0061303)2.42369829
189regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.42052977
190proteasome assembly (GO:0043248)2.41258505
191polyol catabolic process (GO:0046174)2.39952041
192regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.39780499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.32820300
2GATA1_22025678_ChIP-Seq_K562_Human4.54916152
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.31102388
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.99870705
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.62377284
6* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18834367
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.11017283
8POU3F2_20337985_ChIP-ChIP_501MEL_Human3.07307856
9ZNF274_21170338_ChIP-Seq_K562_Hela2.99301959
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.91789809
11GBX2_23144817_ChIP-Seq_PC3_Human2.88755782
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.87415328
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.83924745
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.78486935
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.56632102
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55768378
17EWS_26573619_Chip-Seq_HEK293_Human2.49506656
18FUS_26573619_Chip-Seq_HEK293_Human2.42686390
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.39580944
20IGF1R_20145208_ChIP-Seq_DFB_Human2.39005298
21VDR_23849224_ChIP-Seq_CD4+_Human2.33851547
22P300_19829295_ChIP-Seq_ESCs_Human2.25923740
23KAP1_22055183_ChIP-Seq_ESCs_Mouse2.23178561
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.22296338
25* GABP_19822575_ChIP-Seq_HepG2_Human2.16400439
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15543514
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05275565
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.00404137
29FOXP3_21729870_ChIP-Seq_TREG_Human1.99585174
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94218979
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93239297
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92603331
33* RXR_22158963_ChIP-Seq_LIVER_Mouse1.87435076
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.87401033
35ER_23166858_ChIP-Seq_MCF-7_Human1.82708236
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80594202
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78605403
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77916472
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75582909
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.74939974
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73250673
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.71993633
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71480817
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69366950
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68128493
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66795414
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.66687821
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66533950
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64214621
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62318714
51STAT3_23295773_ChIP-Seq_U87_Human1.60825897
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.60666466
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60331737
54CBP_20019798_ChIP-Seq_JUKART_Human1.60331737
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58946843
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58359840
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58205416
58* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.58182861
59BCAT_22108803_ChIP-Seq_LS180_Human1.57630589
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56595754
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56046297
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.53107347
63* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48296074
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47572166
65* NANOG_18555785_Chip-Seq_ESCs_Mouse1.47407962
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.47203742
67IRF1_19129219_ChIP-ChIP_H3396_Human1.46923879
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46825063
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46460566
70* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43766953
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43567327
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.42540557
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41361704
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41245335
75TCF4_23295773_ChIP-Seq_U87_Human1.41108886
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.41004923
77AR_25329375_ChIP-Seq_VCAP_Human1.39799475
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39793263
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39287329
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38571301
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38060064
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37076857
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35233366
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.34837281
85* KDM5A_27292631_Chip-Seq_BREAST_Human1.33556478
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33051857
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32895694
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31908167
89* P53_22387025_ChIP-Seq_ESCs_Mouse1.30276615
90* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30071414
91NANOG_19829295_ChIP-Seq_ESCs_Human1.29917855
92SOX2_19829295_ChIP-Seq_ESCs_Human1.29917855
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29709994
94* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29705949
95TCF4_22108803_ChIP-Seq_LS180_Human1.29059106
96* CDX2_22108803_ChIP-Seq_LS180_Human1.28777607
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28047708
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27444308
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.26820474
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25044953
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24864092
102DCP1A_22483619_ChIP-Seq_HELA_Human1.24235933
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.23833858
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23292557
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20922382
106E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20748964
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19901902
108* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19556852
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19487071
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19172056
111P300_18555785_Chip-Seq_ESCs_Mouse1.18501148
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.17956168
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17920490
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17106178
115ELK1_19687146_ChIP-ChIP_HELA_Human1.16945069
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16552350
117SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16385588
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16081250
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15684319
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.15629238
121RUNX2_22187159_ChIP-Seq_PCA_Human1.15369091
122OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15073350
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13351485
124NOTCH1_21737748_ChIP-Seq_TLL_Human1.12065839
125SALL1_21062744_ChIP-ChIP_HESCs_Human1.12063556
126* MYC_18940864_ChIP-ChIP_HL60_Human1.12019217
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11020397
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10207150
129SMAD_19615063_ChIP-ChIP_OVARY_Human1.10157554
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.09698032
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09356808
132MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09257572
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07616027
134* JUN_21703547_ChIP-Seq_K562_Human1.07248706
135FLI1_27457419_Chip-Seq_LIVER_Mouse1.07107414
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06914462
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.06838697
138* OCT4_18555785_Chip-Seq_ESCs_Mouse1.06689134
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06400433
140HTT_18923047_ChIP-ChIP_STHdh_Human1.06241378
141YY1_21170310_ChIP-Seq_MESCs_Mouse1.05981561
142TP53_16413492_ChIP-PET_HCT116_Human1.05245908
143* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04975478
144MYC_18555785_ChIP-Seq_MESCs_Mouse1.04888227
145CIITA_25753668_ChIP-Seq_RAJI_Human1.03844024
146* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03583323
147CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03384332
148FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01293561
149NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00118045
150CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98746947
151VDR_22108803_ChIP-Seq_LS180_Human0.97981903
152ZNF263_19887448_ChIP-Seq_K562_Human0.96528219
153TFEB_21752829_ChIP-Seq_HELA_Human0.94046304
154ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93971962
155ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93359397
156* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91456650
157RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89299250
158FOXM1_23109430_ChIP-Seq_U2OS_Human0.89197189
159REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88598862
160* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86281631
161E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85849186
162SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84916108
163HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83258842
164TAF15_26573619_Chip-Seq_HEK293_Human0.81339761
165MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.80774349
166TP53_22573176_ChIP-Seq_HFKS_Human0.80342560
167ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79079838
168TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78134002
169XRN2_22483619_ChIP-Seq_HELA_Human0.77473124
170NANOG_21062744_ChIP-ChIP_HESCs_Human0.76576537
171FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75933326
172* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75544327
173GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75202022
174CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74920036
175EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.72879030
176KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68930283
177ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.68709280
178RBPJ_22232070_ChIP-Seq_NCS_Mouse0.68545328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism5.56519705
2MP0000569_abnormal_digit_pigmentation4.99677319
3MP0008260_abnormal_autophagy4.13655842
4MP0002876_abnormal_thyroid_physiology4.11783968
5MP0008057_abnormal_DNA_replication3.43857837
6MP0003693_abnormal_embryo_hatching3.27762346
7MP0002102_abnormal_ear_morphology3.21238180
8MP0005365_abnormal_bile_salt3.17340611
9MP0003329_amyloid_beta_deposits3.07964098
10MP0005174_abnormal_tail_pigmentation3.06334107
11MP0002139_abnormal_hepatobiliary_system2.94329177
12MP0005379_endocrine/exocrine_gland_phen2.93004197
13MP0000372_irregular_coat_pigmentation2.87483070
14MP0009840_abnormal_foam_cell2.84205285
15MP0002163_abnormal_gland_morphology2.75650515
16MP0000015_abnormal_ear_pigmentation2.73761481
17MP0003718_maternal_effect2.71661013
18MP0008877_abnormal_DNA_methylation2.62070488
19MP0006054_spinal_hemorrhage2.61284441
20MP0004043_abnormal_pH_regulation2.47874354
21MP0005220_abnormal_exocrine_pancreas2.35387563
22MP0000013_abnormal_adipose_tissue2.22250074
23MP0005085_abnormal_gallbladder_physiolo2.20906422
24MP0000604_amyloidosis2.18328118
25MP0005360_urolithiasis2.15440431
26MP0003656_abnormal_erythrocyte_physiolo2.11067290
27MP0005253_abnormal_eye_physiology2.11062491
28MP0000427_abnormal_hair_cycle2.10801496
29MP0005451_abnormal_body_composition2.07415691
30MP0001188_hyperpigmentation2.07340701
31MP0001661_extended_life_span2.05884407
32MP0003646_muscle_fatigue1.99706590
33MP0005551_abnormal_eye_electrophysiolog1.92929425
34MP0002095_abnormal_skin_pigmentation1.92476278
35MP0001944_abnormal_pancreas_morphology1.84288035
36MP0003195_calcinosis1.82488871
37MP0002938_white_spotting1.79815045
38MP0003890_abnormal_embryonic-extraembry1.74494817
39MP0009780_abnormal_chondrocyte_physiolo1.72267618
40MP0008058_abnormal_DNA_repair1.71672242
41MP0005645_abnormal_hypothalamus_physiol1.71475935
42MP0002693_abnormal_pancreas_physiology1.70339205
43MP0001764_abnormal_homeostasis1.62273312
44MP0005408_hypopigmentation1.58656130
45MP0003011_delayed_dark_adaptation1.55362964
46MP0000647_abnormal_sebaceous_gland1.54903551
47MP0005171_absent_coat_pigmentation1.54153287
48MP0005646_abnormal_pituitary_gland1.53379000
49MP0001984_abnormal_olfaction1.53267863
50MP0002653_abnormal_ependyma_morphology1.52317554
51MP0002909_abnormal_adrenal_gland1.44979758
52MP0009672_abnormal_birth_weight1.42733086
53MP0006276_abnormal_autonomic_nervous1.41886416
54MP0005075_abnormal_melanosome_morpholog1.41563783
55MP0005332_abnormal_amino_acid1.41508258
56MP0000383_abnormal_hair_follicle1.37656770
57MP0000371_diluted_coat_color1.36725192
58MP0003136_yellow_coat_color1.35931910
59MP0001324_abnormal_eye_pigmentation1.34012547
60MP0003123_paternal_imprinting1.32572563
61MP0009697_abnormal_copulation1.31678108
62MP0002160_abnormal_reproductive_system1.30303075
63MP0005389_reproductive_system_phenotype1.30040069
64MP0001756_abnormal_urination1.29339567
65MP0010329_abnormal_lipoprotein_level1.28969309
66MP0005058_abnormal_lysosome_morphology1.28929600
67MP0002751_abnormal_autonomic_nervous1.28704443
68MP0008875_abnormal_xenobiotic_pharmacok1.27262396
69MP0002090_abnormal_vision1.26571795
70MP0009046_muscle_twitch1.26556864
71MP0003111_abnormal_nucleus_morphology1.26464229
72MP0001485_abnormal_pinna_reflex1.26138136
73MP0001542_abnormal_bone_strength1.25339495
74MP0004019_abnormal_vitamin_homeostasis1.21891241
75MP0004142_abnormal_muscle_tone1.20895529
76MP0000609_abnormal_liver_physiology1.20869994
77MP0002138_abnormal_hepatobiliary_system1.18764388
78MP0002837_dystrophic_cardiac_calcinosis1.18369268
79MP0002638_abnormal_pupillary_reflex1.16329862
80MP0004264_abnormal_extraembryonic_tissu1.15553992
81MP0005395_other_phenotype1.14533601
82MP0003937_abnormal_limbs/digits/tail_de1.14251065
83MP0009643_abnormal_urine_homeostasis1.10097293
84MP0000631_abnormal_neuroendocrine_gland1.08219257
85MP0001293_anophthalmia1.07847057
86MP0001919_abnormal_reproductive_system1.07773146
87MP0009333_abnormal_splenocyte_physiolog1.07231504
88MP0010678_abnormal_skin_adnexa1.06818619
89MP0002078_abnormal_glucose_homeostasis1.06405776
90MP0000681_abnormal_thyroid_gland1.05593842
91MP0005187_abnormal_penis_morphology1.03187101
92MP0003252_abnormal_bile_duct1.00207799
93MP0005310_abnormal_salivary_gland0.99096597
94MP0003868_abnormal_feces_composition0.97616175
95MP0005195_abnormal_posterior_eye0.97590986
96MP0001119_abnormal_female_reproductive0.96127968
97MP0005636_abnormal_mineral_homeostasis0.94393247
98MP0005367_renal/urinary_system_phenotyp0.94214403
99MP0000516_abnormal_urinary_system0.94214403
100MP0005535_abnormal_body_temperature0.94060041
101MP0003786_premature_aging0.93996813
102MP0004957_abnormal_blastocyst_morpholog0.93972206
103MP0010386_abnormal_urinary_bladder0.92532737
104MP0006292_abnormal_olfactory_placode0.92432016
105MP0005319_abnormal_enzyme/_coenzyme0.92400992
106MP0005671_abnormal_response_to0.92064574
107MP0008872_abnormal_physiological_respon0.91203122
108MP0002118_abnormal_lipid_homeostasis0.90439023
109MP0003121_genomic_imprinting0.89690352
110MP0004134_abnormal_chest_morphology0.88720986
111MP0002277_abnormal_respiratory_mucosa0.87842637
112MP0002234_abnormal_pharynx_morphology0.87832415
113MP0004084_abnormal_cardiac_muscle0.86521066
114MP0003879_abnormal_hair_cell0.86292219
115MP0004215_abnormal_myocardial_fiber0.86196021
116MP0003724_increased_susceptibility_to0.86105406
117MP0003077_abnormal_cell_cycle0.85593968
118MP0003943_abnormal_hepatobiliary_system0.85521214
119MP0009703_decreased_birth_body0.83766471
120MP0005391_vision/eye_phenotype0.83092977
121MP0003953_abnormal_hormone_level0.82928129
122MP0003787_abnormal_imprinting0.81037924
123MP0001986_abnormal_taste_sensitivity0.79751208
124MP0001529_abnormal_vocalization0.79559423
125MP0008775_abnormal_heart_ventricle0.79393085
126MP0000653_abnormal_sex_gland0.78464435
127MP0003567_abnormal_fetal_cardiomyocyte0.78369950
128MP0004133_heterotaxia0.78280009
129MP0001501_abnormal_sleep_pattern0.78202031
130MP0004885_abnormal_endolymph0.76680698
131MP0002877_abnormal_melanocyte_morpholog0.75931053
132MP0000462_abnormal_digestive_system0.75887436
133MP0005248_abnormal_Harderian_gland0.75509646
134MP0002075_abnormal_coat/hair_pigmentati0.75483699
135MP0008007_abnormal_cellular_replicative0.75252051
136MP0008995_early_reproductive_senescence0.74807714
137MP0005084_abnormal_gallbladder_morpholo0.74002498
138MP0008789_abnormal_olfactory_epithelium0.74002322
139MP0000613_abnormal_salivary_gland0.71252770
140MP0003172_abnormal_lysosome_physiology0.70831518
141MP0002177_abnormal_outer_ear0.70409681
142MP0002272_abnormal_nervous_system0.69705009
143MP0001186_pigmentation_phenotype0.69403316
144MP0003950_abnormal_plasma_membrane0.69050039
145MP0005266_abnormal_metabolism0.68328419
146MP0001486_abnormal_startle_reflex0.68036856
147MP0006035_abnormal_mitochondrial_morpho0.67373710
148MP0003122_maternal_imprinting0.67353001
149MP0000598_abnormal_liver_morphology0.66826001
150MP0009642_abnormal_blood_homeostasis0.66815267
151MP0004924_abnormal_behavior0.66431401
152MP0004270_analgesia0.64417040
153MP0000358_abnormal_cell_content/0.64197878
154MP0003880_abnormal_central_pattern0.63203790
155MP0006072_abnormal_retinal_apoptosis0.63162023
156MP0000230_abnormal_systemic_arterial0.62024266
157MP0008469_abnormal_protein_level0.60541446
158MP0001730_embryonic_growth_arrest0.60187211
159MP0006036_abnormal_mitochondrial_physio0.59441419
160MP0010094_abnormal_chromosome_stability0.58901634
161MP0000639_abnormal_adrenal_gland0.58221840
162MP0008932_abnormal_embryonic_tissue0.57668911
163MP0004036_abnormal_muscle_relaxation0.55093863
164MP0001929_abnormal_gametogenesis0.55016400
165MP0002928_abnormal_bile_duct0.54718555
166MP0001727_abnormal_embryo_implantation0.53635283

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal dysplasia (HP:0100255)5.61752855
2Prostate neoplasm (HP:0100787)4.71398590
3Hyperglycemia (HP:0003074)3.91518874
4Hyperglycinemia (HP:0002154)3.91026477
5Short middle phalanx of the 5th finger (HP:0004220)3.80385986
6Agnosia (HP:0010524)3.79920568
7Pancreatic cysts (HP:0001737)3.73175373
8Carpal bone hypoplasia (HP:0001498)3.70521580
9Polyphagia (HP:0002591)3.64489150
10Abnormality of glycolipid metabolism (HP:0010969)3.54212055
11Abnormality of liposaccharide metabolism (HP:0010968)3.54212055
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.54212055
13Insulin-resistant diabetes mellitus (HP:0000831)3.46160086
14Gout (HP:0001997)3.38744198
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.35911907
16Birth length less than 3rd percentile (HP:0003561)3.32971090
17Spondylolisthesis (HP:0003302)3.32773069
18Methylmalonic acidemia (HP:0002912)3.12996627
19Molar tooth sign on MRI (HP:0002419)3.10762290
20Abnormality of midbrain morphology (HP:0002418)3.10762290
21Thoracolumbar scoliosis (HP:0002944)3.10082074
22Cerebral hypomyelination (HP:0006808)3.08258768
23Atrophy/Degeneration involving motor neurons (HP:0007373)3.06305172
24True hermaphroditism (HP:0010459)3.05043417
25Abnormality of lateral ventricle (HP:0030047)2.98410230
26Neurofibrillary tangles (HP:0002185)2.89445360
27Personality changes (HP:0000751)2.86469573
28Abnormality of the anterior horn cell (HP:0006802)2.83422966
29Degeneration of anterior horn cells (HP:0002398)2.83422966
30Amyotrophic lateral sclerosis (HP:0007354)2.82959581
31Hyperglycinuria (HP:0003108)2.77519910
32Abnormality of chromosome stability (HP:0003220)2.77515453
33Thyroiditis (HP:0100646)2.74810871
34Medial flaring of the eyebrow (HP:0010747)2.71714140
35Hypoplastic scapulae (HP:0000882)2.71524044
36Aplasia/Hypoplasia of the scapulae (HP:0006713)2.71524044
37Lower limb hyperreflexia (HP:0002395)2.70453560
38Bundle branch block (HP:0011710)2.68659677
39Albinism (HP:0001022)2.66468834
40Hyperinsulinemic hypoglycemia (HP:0000825)2.66386212
41Nephronophthisis (HP:0000090)2.63470504
42Abnormality of the renal cortex (HP:0011035)2.60992236
43Hypoglycemic coma (HP:0001325)2.60658895
44Abolished electroretinogram (ERG) (HP:0000550)2.59836158
45Irritability (HP:0000737)2.56984475
46Chronic hepatic failure (HP:0100626)2.56083446
47Hyperventilation (HP:0002883)2.54175032
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.53382022
49Hypoglycemic seizures (HP:0002173)2.53215395
50Protuberant abdomen (HP:0001538)2.51969685
51Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.49376012
52Abnormality of the renal medulla (HP:0100957)2.47229178
53CNS hypomyelination (HP:0003429)2.44595579
54Congenital stationary night blindness (HP:0007642)2.43434360
55Abnormality of vitamin B metabolism (HP:0004340)2.41111869
56Intestinal atresia (HP:0011100)2.40458184
57Recurrent bacterial skin infections (HP:0005406)2.39116703
58Abnormality of serine family amino acid metabolism (HP:0010894)2.38854138
59Abnormality of glycine metabolism (HP:0010895)2.38854138
60Abnormality of serum amino acid levels (HP:0003112)2.38023782
61Abnormality of the vitamin B12 metabolism (HP:0004341)2.35768255
62Spastic tetraparesis (HP:0001285)2.33699193
63Prolonged neonatal jaundice (HP:0006579)2.32642121
64Pancreatic fibrosis (HP:0100732)2.32524515
65Secondary amenorrhea (HP:0000869)2.29793971
66Volvulus (HP:0002580)2.29082953
67Abnormality of DNA repair (HP:0003254)2.29043909
68Congenital primary aphakia (HP:0007707)2.26563119
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26091905
70Abnormal neuron morphology (HP:0012757)2.25291113
71Abnormality of the motor neurons (HP:0002450)2.25291113
72Methylmalonic aciduria (HP:0012120)2.25236268
73Dysautonomia (HP:0002459)2.24597886
74Ketoacidosis (HP:0001993)2.22173854
75Symptomatic seizures (HP:0011145)2.22023533
76Thickened calvaria (HP:0002684)2.21169613
77Nephrogenic diabetes insipidus (HP:0009806)2.20789038
78Vertebral arch anomaly (HP:0008438)2.20598848
79Abnormal pancreas size (HP:0012094)2.19521398
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19508841
81Abnormality of alanine metabolism (HP:0010916)2.19508841
82Hyperalaninemia (HP:0003348)2.19508841
83Entropion (HP:0000621)2.18824189
84Gaze-evoked nystagmus (HP:0000640)2.18619457
85Gait imbalance (HP:0002141)2.18029684
86Hypothermia (HP:0002045)2.17347988
87Abnormality of the prostate (HP:0008775)2.16821116
88Congenital sensorineural hearing impairment (HP:0008527)2.15564547
89Oligomenorrhea (HP:0000876)2.14814222
90Adrenal hypoplasia (HP:0000835)2.14730890
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.14659836
92Short clavicles (HP:0000894)2.14457996
93Syringomyelia (HP:0003396)2.14157446
94Spinal cord lesions (HP:0100561)2.14157446
95Microglossia (HP:0000171)2.13108540
96Spinal muscular atrophy (HP:0007269)2.12649869
97Aplasia/Hypoplasia of the fovea (HP:0008060)2.12414738
98Hypoplasia of the fovea (HP:0007750)2.12414738
99Delusions (HP:0000746)2.12333617
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.12078457
101Genital tract atresia (HP:0001827)2.12045083
102Anterior segment dysgenesis (HP:0007700)2.12015770
103Colon cancer (HP:0003003)2.11341889
104Restlessness (HP:0000711)2.10708941
105Genetic anticipation (HP:0003743)2.08982163
106Abnormality of the ileum (HP:0001549)2.08639787
107Epileptiform EEG discharges (HP:0011182)2.07984937
108Meckel diverticulum (HP:0002245)2.06512240
109Vaginal atresia (HP:0000148)2.05434008
110EEG with generalized epileptiform discharges (HP:0011198)2.05311372
111Hypsarrhythmia (HP:0002521)2.05155458
112Abnormal eating behavior (HP:0100738)2.04970980
113Neoplasm of the adrenal cortex (HP:0100641)2.04929371
114Disproportionate short-trunk short stature (HP:0003521)2.04053825
115Conjugated hyperbilirubinemia (HP:0002908)2.02938909
116Sloping forehead (HP:0000340)2.00679915
117Cerebral inclusion bodies (HP:0100314)1.99194297
118Chorioretinal atrophy (HP:0000533)1.98458210
119Progressive inability to walk (HP:0002505)1.98380795
120Absent frontal sinuses (HP:0002688)1.98195882
121Renal cortical cysts (HP:0000803)1.98177502
122Pendular nystagmus (HP:0012043)1.98064929
123Mucopolysacchariduria (HP:0008155)1.97869000
124Urinary glycosaminoglycan excretion (HP:0003541)1.97869000
125Abnormality of the labia minora (HP:0012880)1.97824040
126Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.97697970
127Abnormality of dental color (HP:0011073)1.96283192
128Abnormality of the intrinsic pathway (HP:0010989)1.96169787
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.95834936
130Clubbing of toes (HP:0100760)1.93695033
131Hypoplastic iliac wings (HP:0002866)1.93632562
132Tubulointerstitial nephritis (HP:0001970)1.93189658
133Disinhibition (HP:0000734)1.92726433
134Dysostosis multiplex (HP:0000943)1.92624151
135Apathy (HP:0000741)1.92202985
136Impulsivity (HP:0100710)1.92027611
137Capillary hemangiomas (HP:0005306)1.89821506
138Prolonged partial thromboplastin time (HP:0003645)1.89615164
139Cystic liver disease (HP:0006706)1.88929206
140Astigmatism (HP:0000483)1.88814102
141Abnormality of the fovea (HP:0000493)1.88646127
142Abnormality of the common coagulation pathway (HP:0010990)1.88491685
143Intrahepatic cholestasis (HP:0001406)1.88227976
144Submucous cleft hard palate (HP:0000176)1.88219044
145Furrowed tongue (HP:0000221)1.88213724
146Ketosis (HP:0001946)1.87397501
147Neuroendocrine neoplasm (HP:0100634)1.87131231
148Oligodactyly (hands) (HP:0001180)1.86910982
149Glucose intolerance (HP:0000833)1.86475481
150Abnormality of the phalanges of the 2nd finger (HP:0009541)1.85902774
151Xanthomatosis (HP:0000991)1.85356801
152Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.84759018
153Abnormality of polysaccharide metabolism (HP:0011012)1.84567345
154Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84567345
155Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84567345
156Postaxial foot polydactyly (HP:0001830)1.84363093
157Abnormality of monocarboxylic acid metabolism (HP:0010996)1.83661108
158Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83643087
159Abnormality of the metopic suture (HP:0005556)1.81837670
160Abnormality of the wing of the ilium (HP:0011867)1.81410199
161Hypoplastic pelvis (HP:0008839)1.81390744
162Rhabdomyosarcoma (HP:0002859)1.79551209
163Preaxial hand polydactyly (HP:0001177)1.78732356
164Postaxial hand polydactyly (HP:0001162)1.78150717
165Attenuation of retinal blood vessels (HP:0007843)1.77574776
166Poor coordination (HP:0002370)1.77434214
167Abnormality of the preputium (HP:0100587)1.77399634
168Fair hair (HP:0002286)1.77263845
169Duodenal stenosis (HP:0100867)1.77145569
170Small intestinal stenosis (HP:0012848)1.77145569
171Dandy-Walker malformation (HP:0001305)1.76532693
172Chromsome breakage (HP:0040012)1.75024114
173Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74577366
174Abnormality of homocysteine metabolism (HP:0010919)1.73657433
175Homocystinuria (HP:0002156)1.73657433
176Abnormality of the duodenum (HP:0002246)1.72824963
177Anencephaly (HP:0002323)1.72622262
178Ectopic kidney (HP:0000086)1.72162188
179Male pseudohermaphroditism (HP:0000037)1.71788383
180Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71203100
181Degeneration of the lateral corticospinal tracts (HP:0002314)1.71203100
182Growth hormone deficiency (HP:0000824)1.70774249
183Curly hair (HP:0002212)1.69452785
184Cutaneous melanoma (HP:0012056)1.69442989
185Sclerocornea (HP:0000647)1.69296895
186Pancreatic islet-cell hyperplasia (HP:0004510)1.69166245
187Hypomagnesemia (HP:0002917)1.68856524
188Bifid tongue (HP:0010297)1.68510145
189Congenital hepatic fibrosis (HP:0002612)1.68422965
190Progressive cerebellar ataxia (HP:0002073)1.68102556
191Inability to walk (HP:0002540)1.65934976
192Aqueductal stenosis (HP:0002410)1.65616753
193Short tibia (HP:0005736)1.65181399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.58451772
2AKT33.44871714
3PIK3CG3.32933314
4ACVR1B3.17517101
5MAP4K22.73462860
6TRIM282.67013471
7MAP3K22.65183592
8CCNB12.59118836
9PLK42.41788831
10IRAK32.23759442
11TAOK32.19961859
12BRAF2.16467565
13INSRR2.14867083
14STK162.08351937
15FLT32.06194252
16ERBB32.06040897
17TNIK2.05154901
18EIF2AK32.05128064
19MAP3K32.04913033
20CAMKK22.02229138
21BCR1.91714159
22MAP3K91.89321696
23GRK11.82939394
24BRSK21.80642856
25WEE11.80423992
26JAK31.78933227
27TSSK61.74406231
28ARAF1.69499839
29NTRK11.56176783
30PLK21.55804116
31MKNK11.54741341
32ZAK1.52036840
33PASK1.50481715
34BMPR21.48670365
35EIF2AK11.47942851
36EPHA21.45703381
37ADRBK21.45426258
38LATS21.37859220
39PLK31.34491145
40MAPK131.32685273
41STK391.28903122
42BRSK11.28506238
43STK38L1.28504608
44MST41.28085919
45OXSR11.25316102
46DYRK1A1.24674820
47FGFR41.17868367
48PBK1.15508527
49NEK21.11972329
50RIPK41.11876878
51MAP2K71.04862760
52CSNK1G21.02037309
53FRK1.02035249
54NEK61.01338640
55FER1.01224330
56PDK40.96917641
57PDK30.96917641
58PRKCE0.92667997
59TXK0.90046860
60PLK10.89161066
61MAP3K60.87924447
62MELK0.86994780
63BMPR1B0.85859135
64PAK60.85575551
65CSNK1A1L0.82786124
66VRK10.81537404
67ERBB40.80183754
68KSR10.78147641
69DYRK20.77800030
70TGFBR10.76533977
71MARK10.75930841
72PDK20.75676577
73PIK3CA0.75143183
74NEK10.72633875
75LATS10.72555008
76PNCK0.72179336
77MAP2K20.70690836
78MAP3K40.70547546
79TLK10.68525273
80PRKAA10.67921180
81BCKDK0.67074668
82SGK20.66791696
83DYRK30.66532097
84FGFR20.65837542
85EPHA30.65520147
86ADRBK10.65256060
87MAPK40.64836541
88IRAK10.64823934
89STK240.64445321
90ZAP700.63617972
91RPS6KB10.63599634
92TTK0.62888136
93NEK90.62067051
94SRPK10.61150304
95MAP2K40.60817946
96PRKCG0.60785098
97STK30.60684814
98PINK10.59686081
99WNK30.58912147
100CHEK20.58570191
101TAF10.57395837
102PDPK10.56708018
103NTRK30.55311998
104CDK180.55294430
105IRAK40.53957487
106MAP3K130.53752818
107TEC0.52422208
108ATR0.51740468
109CDK150.51663011
110PRKCI0.51636284
111WNK40.51166217
112MAP3K140.49706411
113NLK0.49107546
114SIK30.47423224
115PAK30.47401889
116NUAK10.46740927
117ATM0.46515271
118RAF10.45639030
119PDK10.45120660
120CDK140.44094944
121MAP3K80.43812297
122PKN10.43090373
123CDK11A0.41680951
124CDK80.41619193
125YES10.41280165
126STK110.40122312
127TRPM70.40043253
128ERN10.39089579
129MKNK20.38211841
130EPHA40.37731021
131CDK90.37714681
132CSNK1G30.37316898
133PRKCZ0.36944340
134MAP2K10.36864401
135CASK0.36687337
136MARK30.36649392
137SGK2230.36189325
138SGK4940.36189325
139CSNK1G10.35539757
140EIF2AK20.33780855
141CAMK2A0.33284267
142OBSCN0.33066284
143CDC70.32732009
144DAPK20.31347676
145FGFR10.30504904
146GRK70.30297358
147PTK2B0.30245251
148MAPKAPK50.29976156
149MAP3K50.29187330
150BRD40.28715229
151RPS6KA50.28519340
152MAP3K120.28455609
153CSNK1A10.28130554
154ERBB20.26956759

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.12235570
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.24297288
3Regulation of autophagy_Homo sapiens_hsa041403.76762946
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.69360356
5RNA polymerase_Homo sapiens_hsa030203.23123539
6Protein export_Homo sapiens_hsa030602.86558154
7Folate biosynthesis_Homo sapiens_hsa007902.72802964
8Non-homologous end-joining_Homo sapiens_hsa034502.59301647
9Propanoate metabolism_Homo sapiens_hsa006402.51074127
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47284531
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.09961869
12Selenocompound metabolism_Homo sapiens_hsa004502.05704957
13Phototransduction_Homo sapiens_hsa047442.05212517
14Homologous recombination_Homo sapiens_hsa034402.03933801
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99858780
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.85321010
17Proteasome_Homo sapiens_hsa030501.79843286
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.78712845
19Basal transcription factors_Homo sapiens_hsa030221.75661697
20Nitrogen metabolism_Homo sapiens_hsa009101.75654421
21Vitamin digestion and absorption_Homo sapiens_hsa049771.70939532
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69241752
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.67185171
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66631275
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63762772
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61570947
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.54839761
28Pyrimidine metabolism_Homo sapiens_hsa002401.45121011
29Caffeine metabolism_Homo sapiens_hsa002321.43528396
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43335335
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43141479
32Butanoate metabolism_Homo sapiens_hsa006501.42737369
33Circadian rhythm_Homo sapiens_hsa047101.41632969
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.39005748
35Ether lipid metabolism_Homo sapiens_hsa005651.38070729
36Sulfur metabolism_Homo sapiens_hsa009201.35760113
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.34347688
38Nicotine addiction_Homo sapiens_hsa050331.32944276
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31510903
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30537378
41Oocyte meiosis_Homo sapiens_hsa041141.28230425
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26536788
43Vibrio cholerae infection_Homo sapiens_hsa051101.26428644
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25799280
45Tryptophan metabolism_Homo sapiens_hsa003801.25340068
46Lysosome_Homo sapiens_hsa041421.22034374
47Purine metabolism_Homo sapiens_hsa002301.21364273
48Chemical carcinogenesis_Homo sapiens_hsa052041.20557783
49Collecting duct acid secretion_Homo sapiens_hsa049661.18783286
50Fatty acid elongation_Homo sapiens_hsa000621.18016720
51RNA transport_Homo sapiens_hsa030131.14711833
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10200086
53Taste transduction_Homo sapiens_hsa047421.09788732
54Synaptic vesicle cycle_Homo sapiens_hsa047211.08352941
55Insulin secretion_Homo sapiens_hsa049111.06716561
56Mismatch repair_Homo sapiens_hsa034301.03918405
57Cell cycle_Homo sapiens_hsa041101.02017567
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00312118
59One carbon pool by folate_Homo sapiens_hsa006700.92012125
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90427485
61Pentose phosphate pathway_Homo sapiens_hsa000300.89071496
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88242936
63RNA degradation_Homo sapiens_hsa030180.87722377
64Epstein-Barr virus infection_Homo sapiens_hsa051690.87441830
65Steroid biosynthesis_Homo sapiens_hsa001000.84488149
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84179785
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79781420
68Arginine biosynthesis_Homo sapiens_hsa002200.75702245
69Type II diabetes mellitus_Homo sapiens_hsa049300.74466967
70Serotonergic synapse_Homo sapiens_hsa047260.73591499
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73059973
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72032431
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71546202
74Oxidative phosphorylation_Homo sapiens_hsa001900.71239844
75Complement and coagulation cascades_Homo sapiens_hsa046100.70674130
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70180242
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69277399
78mTOR signaling pathway_Homo sapiens_hsa041500.68858597
79Phenylalanine metabolism_Homo sapiens_hsa003600.68450051
80Prolactin signaling pathway_Homo sapiens_hsa049170.68060173
81Ovarian steroidogenesis_Homo sapiens_hsa049130.67828134
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67527252
83Histidine metabolism_Homo sapiens_hsa003400.65926367
84Glycerolipid metabolism_Homo sapiens_hsa005610.65551419
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64971441
86Fatty acid degradation_Homo sapiens_hsa000710.64912229
87Dorso-ventral axis formation_Homo sapiens_hsa043200.62873726
88Arachidonic acid metabolism_Homo sapiens_hsa005900.61740815
89Fatty acid metabolism_Homo sapiens_hsa012120.61298546
90Olfactory transduction_Homo sapiens_hsa047400.58902032
91Fatty acid biosynthesis_Homo sapiens_hsa000610.58444289
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58424642
93Fat digestion and absorption_Homo sapiens_hsa049750.57359494
94Starch and sucrose metabolism_Homo sapiens_hsa005000.55140124
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52359973
96Biosynthesis of amino acids_Homo sapiens_hsa012300.52002581
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51737904
98FoxO signaling pathway_Homo sapiens_hsa040680.51372547
99TGF-beta signaling pathway_Homo sapiens_hsa043500.49173789
100ABC transporters_Homo sapiens_hsa020100.48563510
101Rheumatoid arthritis_Homo sapiens_hsa053230.47978331
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47884879
103Lysine degradation_Homo sapiens_hsa003100.46961294
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46870347
105Morphine addiction_Homo sapiens_hsa050320.46525563
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46394287
107p53 signaling pathway_Homo sapiens_hsa041150.46175153
108Hedgehog signaling pathway_Homo sapiens_hsa043400.45819677
109Peroxisome_Homo sapiens_hsa041460.44024959
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44008761
111beta-Alanine metabolism_Homo sapiens_hsa004100.43869454
112Systemic lupus erythematosus_Homo sapiens_hsa053220.43658946
113Amphetamine addiction_Homo sapiens_hsa050310.43347689
114Metabolic pathways_Homo sapiens_hsa011000.43284999
115Long-term depression_Homo sapiens_hsa047300.42932403
116Cocaine addiction_Homo sapiens_hsa050300.42748997
117Phagosome_Homo sapiens_hsa041450.42735380
118Insulin resistance_Homo sapiens_hsa049310.38554366
119Inositol phosphate metabolism_Homo sapiens_hsa005620.38314935
120Fructose and mannose metabolism_Homo sapiens_hsa000510.37462953
121Sulfur relay system_Homo sapiens_hsa041220.37146763
122Staphylococcus aureus infection_Homo sapiens_hsa051500.36894567
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35541716
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35315787
125Other glycan degradation_Homo sapiens_hsa005110.34264663
126Retinol metabolism_Homo sapiens_hsa008300.33568290
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33460068
128Prion diseases_Homo sapiens_hsa050200.32922672
129Nucleotide excision repair_Homo sapiens_hsa034200.32863989
130Huntingtons disease_Homo sapiens_hsa050160.31744124
131Melanoma_Homo sapiens_hsa052180.31633557
132Tyrosine metabolism_Homo sapiens_hsa003500.31249864
133Salivary secretion_Homo sapiens_hsa049700.30870025
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30621696
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30183306
136Fanconi anemia pathway_Homo sapiens_hsa034600.29721834
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29615401
138Linoleic acid metabolism_Homo sapiens_hsa005910.29524143
139Hippo signaling pathway_Homo sapiens_hsa043900.29289733
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.28952924
141Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28642960
142Sphingolipid metabolism_Homo sapiens_hsa006000.28109677
143Arginine and proline metabolism_Homo sapiens_hsa003300.25859581
144N-Glycan biosynthesis_Homo sapiens_hsa005100.24518201
145Antigen processing and presentation_Homo sapiens_hsa046120.24324991
146Type I diabetes mellitus_Homo sapiens_hsa049400.24076539
147GABAergic synapse_Homo sapiens_hsa047270.23199314
148Legionellosis_Homo sapiens_hsa051340.22665558
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.22417225
150Bile secretion_Homo sapiens_hsa049760.22069722
151mRNA surveillance pathway_Homo sapiens_hsa030150.20315179
152Hepatitis C_Homo sapiens_hsa051600.17362365

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