GDE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.64810144
2synaptic vesicle maturation (GO:0016188)4.59374227
3synaptic vesicle exocytosis (GO:0016079)4.43774318
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.38429703
5neuronal action potential propagation (GO:0019227)4.34500644
6regulation of synaptic vesicle exocytosis (GO:2000300)4.25059124
7COPI coating of Golgi vesicle (GO:0048205)4.16479566
8Golgi transport vesicle coating (GO:0048200)4.16479566
9glutamate secretion (GO:0014047)4.05625992
10negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.05285478
11NADH metabolic process (GO:0006734)3.81149999
12regulation of synaptic vesicle transport (GO:1902803)3.77176772
13positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.74342096
14axon ensheathment in central nervous system (GO:0032291)3.73076166
15central nervous system myelination (GO:0022010)3.73076166
16locomotory exploration behavior (GO:0035641)3.68633400
17cellular potassium ion homeostasis (GO:0030007)3.63214712
18antigen processing and presentation via MHC class Ib (GO:0002475)3.57610501
19protein retention in ER lumen (GO:0006621)3.53114460
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.52127307
21proline biosynthetic process (GO:0006561)3.48584274
22vocalization behavior (GO:0071625)3.42017386
23neuron cell-cell adhesion (GO:0007158)3.39485938
24protein localization to synapse (GO:0035418)3.36962277
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.33600036
26negative regulation of catenin import into nucleus (GO:0035414)3.33302721
27nucleoside diphosphate biosynthetic process (GO:0009133)3.27495752
28regulation of neuronal synaptic plasticity (GO:0048168)3.22250505
29low-density lipoprotein particle clearance (GO:0034383)3.21558549
30positive regulation of Rho protein signal transduction (GO:0035025)3.16781359
31neurotransmitter secretion (GO:0007269)3.16338564
32regulation of integrin-mediated signaling pathway (GO:2001044)3.15602976
33protein maturation by protein folding (GO:0022417)3.15228171
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.14315260
35desmosome organization (GO:0002934)3.11085443
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.10332861
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.06869384
38neuromuscular process controlling posture (GO:0050884)3.06172570
39gamma-aminobutyric acid transport (GO:0015812)3.05751253
40alpha-linolenic acid metabolic process (GO:0036109)3.04675375
41regulation of synapse structural plasticity (GO:0051823)3.03840406
42nucleobase-containing small molecule interconversion (GO:0015949)3.02668996
43layer formation in cerebral cortex (GO:0021819)3.01913607
44exploration behavior (GO:0035640)3.00078935
45transmission of nerve impulse (GO:0019226)2.99489392
46synaptic transmission, glutamatergic (GO:0035249)2.98841535
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98595107
48regulation of glutamate receptor signaling pathway (GO:1900449)2.98392888
49mitotic nuclear envelope reassembly (GO:0007084)2.97592389
50nuclear envelope reassembly (GO:0031468)2.97592389
51proline transport (GO:0015824)2.95335167
52energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.93659912
53ATP hydrolysis coupled proton transport (GO:0015991)2.93659912
54mitochondrial calcium ion homeostasis (GO:0051560)2.92081136
55mating behavior (GO:0007617)2.91550301
56cellular copper ion homeostasis (GO:0006878)2.89661452
57DNA strand renaturation (GO:0000733)2.89098565
58sodium ion export (GO:0071436)2.87738064
59neuron-neuron synaptic transmission (GO:0007270)2.87493052
60glutamate receptor signaling pathway (GO:0007215)2.87441460
61positive regulation of membrane potential (GO:0045838)2.87344219
62retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86997437
63regulation of vesicle fusion (GO:0031338)2.86214387
64barbed-end actin filament capping (GO:0051016)2.85414594
65regulation of amyloid precursor protein catabolic process (GO:1902991)2.83808458
66epithelial cell-cell adhesion (GO:0090136)2.82562773
67neuron recognition (GO:0008038)2.81554488
68regulation of cholesterol storage (GO:0010885)2.81464551
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.80520087
70neurotransmitter transport (GO:0006836)2.79045290
71regulation of sequestering of triglyceride (GO:0010889)2.78219698
72triglyceride catabolic process (GO:0019433)2.77497040
73triglyceride biosynthetic process (GO:0019432)2.77368329
74negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.76246985
75gamma-aminobutyric acid signaling pathway (GO:0007214)2.75911416
76fatty acid homeostasis (GO:0055089)2.72565206
77mitochondrial fusion (GO:0008053)2.70344732
78glycine transport (GO:0015816)2.70257586
79transferrin transport (GO:0033572)2.69782724
80bundle of His cell to Purkinje myocyte communication (GO:0086069)2.68290505
81synaptic vesicle docking involved in exocytosis (GO:0016081)2.68173296
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67537662
83regulation of neurotransmitter secretion (GO:0046928)2.67441041
84peroxisome fission (GO:0016559)2.66994291
85detection of calcium ion (GO:0005513)2.66963053
86dendritic spine morphogenesis (GO:0060997)2.66690651
87long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.64562117
88tricarboxylic acid cycle (GO:0006099)2.63703265
89negative regulation of neurotransmitter transport (GO:0051589)2.63327803
90activation of protein kinase A activity (GO:0034199)2.62735030
91regulation of synaptic plasticity (GO:0048167)2.62680450
92neuronal ion channel clustering (GO:0045161)2.61757746
93long-term memory (GO:0007616)2.61490815
94negative regulation of protein localization to plasma membrane (GO:1903077)2.61256482
95neutral lipid biosynthetic process (GO:0046460)2.60740953
96acylglycerol biosynthetic process (GO:0046463)2.60740953
97regulation of excitatory postsynaptic membrane potential (GO:0060079)2.59651583
98negative regulation of protein localization to cell surface (GO:2000009)2.59607073
99potassium ion import (GO:0010107)2.58922456
100adult walking behavior (GO:0007628)2.58700618
101neutral lipid catabolic process (GO:0046461)2.58275850
102acylglycerol catabolic process (GO:0046464)2.58275850
103regulation of oxidative phosphorylation (GO:0002082)2.56886275
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.54750351
105regulation of dendritic spine morphogenesis (GO:0061001)2.54719356
106long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.54481191
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.54111411
108regulation of neurotransmitter levels (GO:0001505)2.53659516
109very-low-density lipoprotein particle assembly (GO:0034379)2.53603911
110fatty-acyl-CoA biosynthetic process (GO:0046949)2.53514727
111calcium ion-dependent exocytosis (GO:0017156)2.53056243
112negative regulation of amino acid transport (GO:0051956)2.52959496
113potassium ion homeostasis (GO:0055075)2.52641626
114trivalent inorganic cation transport (GO:0072512)2.52208396
115ferric iron transport (GO:0015682)2.52208396
116acyl-CoA biosynthetic process (GO:0071616)2.51445643
117thioester biosynthetic process (GO:0035384)2.51445643
118regulation of voltage-gated calcium channel activity (GO:1901385)2.51382524
119protein targeting to plasma membrane (GO:0072661)2.51284427
120apoptotic cell clearance (GO:0043277)2.51235548
121regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50513878
122establishment of mitochondrion localization (GO:0051654)2.50315862
123L-amino acid import (GO:0043092)2.49446233
124dendrite morphogenesis (GO:0048813)2.48952392
125pentose-phosphate shunt (GO:0006098)2.48874100
126regulation of glutamate secretion (GO:0014048)2.48824797
127neuromuscular process controlling balance (GO:0050885)2.48466378
128regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.48279612
129vesicle transport along microtubule (GO:0047496)2.47396681
130positive regulation of potassium ion transport (GO:0043268)2.47229547
131regulation of neurotransmitter transport (GO:0051588)2.46945293
132calcium-mediated signaling using intracellular calcium source (GO:0035584)2.46320076
133organelle transport along microtubule (GO:0072384)2.46103941
134regulation of postsynaptic membrane potential (GO:0060078)2.45973812
135membrane hyperpolarization (GO:0060081)2.45798709
136tight junction assembly (GO:0070830)2.45661524
137regulation of early endosome to late endosome transport (GO:2000641)2.45498974
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45476357
139presynaptic membrane assembly (GO:0097105)2.44604639
140negative regulation of response to reactive oxygen species (GO:1901032)2.44214222
141glucose catabolic process (GO:0006007)2.43820060
142detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.43532663
143detection of temperature stimulus involved in sensory perception (GO:0050961)2.43532663
144carnitine shuttle (GO:0006853)2.43429677
145presynaptic membrane organization (GO:0097090)2.42869340
146long-term synaptic potentiation (GO:0060291)2.42853118
147positive regulation of exocytosis (GO:0045921)2.42744296
148negative regulation of neurotransmitter secretion (GO:0046929)2.42674301
149negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.41257286
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.41117365
151L-phenylalanine metabolic process (GO:0006558)2.41117365
152membrane repolarization (GO:0086009)2.40936085
153positive regulation of receptor recycling (GO:0001921)2.39915536
154protein localization to endosome (GO:0036010)2.39775866
155synaptic vesicle endocytosis (GO:0048488)2.39775617
156protoporphyrinogen IX metabolic process (GO:0046501)2.39519864
157cerebellar granule cell differentiation (GO:0021707)2.39306389
158positive regulation of synaptic transmission, GABAergic (GO:0032230)2.39257262
159positive regulation of potassium ion transmembrane transport (GO:1901381)2.39251270
160regulation of exocytosis (GO:0017157)2.38932638
161mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.38840464
162ribosomal small subunit biogenesis (GO:0042274)2.38603178
163axonal fasciculation (GO:0007413)2.38598726
164cell communication by electrical coupling (GO:0010644)2.38307842
165L-serine transport (GO:0015825)2.38162448
166regulation of synaptic transmission, glutamatergic (GO:0051966)2.37157009
167regulation of calcium ion-dependent exocytosis (GO:0017158)2.37061678
168NADPH regeneration (GO:0006740)2.37054228
169positive regulation of actin filament depolymerization (GO:0030836)2.36936017
170amyloid precursor protein catabolic process (GO:0042987)2.36034395
171response to muscle activity (GO:0014850)2.35207081
172amyloid precursor protein metabolic process (GO:0042982)2.34143761
173tricarboxylic acid metabolic process (GO:0072350)2.34086278
174endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.33641390
175regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.32107481
176glycogen catabolic process (GO:0005980)2.31553606
177heme biosynthetic process (GO:0006783)2.29833239
178receptor recycling (GO:0001881)2.26910850
179regulation of cellular respiration (GO:0043457)2.26219240
180intestinal epithelial cell development (GO:0060576)2.25610849
181cGMP-mediated signaling (GO:0019934)2.25607059
182regulation of protein localization to cell surface (GO:2000008)2.24903335
183muscle cell migration (GO:0014812)2.24621247
184glucan catabolic process (GO:0009251)2.24033800
185sarcomere organization (GO:0045214)2.23522388
186negative regulation of granulocyte differentiation (GO:0030853)2.20720155
187linoleic acid metabolic process (GO:0043651)2.20124351
188stress fiber assembly (GO:0043149)2.19579738
189regulation of hydrogen peroxide-induced cell death (GO:1903205)2.19575426
190triglyceride metabolic process (GO:0006641)2.19539811
191proline metabolic process (GO:0006560)2.18604870
192heme metabolic process (GO:0042168)2.18358938
193urea cycle (GO:0000050)2.17804493
194porphyrin-containing compound biosynthetic process (GO:0006779)2.16646766
195tetrapyrrole biosynthetic process (GO:0033014)2.16294302
196beta-amyloid metabolic process (GO:0050435)2.16198996
197regulation of cholesterol biosynthetic process (GO:0045540)2.16016798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.70197934
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.33636353
3ZNF263_19887448_ChIP-Seq_K562_Human4.29667663
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.26444582
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.16680050
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96158180
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87320096
8GBX2_23144817_ChIP-Seq_PC3_Human2.78391288
9CLOCK_20551151_ChIP-Seq_293T_Human2.77735969
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.70046812
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.65281450
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65149090
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61888639
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61197045
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60128395
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.57588243
17REST_21632747_ChIP-Seq_MESCs_Mouse2.56697122
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47463119
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45513547
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45513547
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44390721
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42728699
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35837792
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.35399241
25RACK7_27058665_Chip-Seq_MCF-7_Human2.31973785
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29149077
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25158871
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.23317616
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20651290
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.18381522
31ESR1_20079471_ChIP-ChIP_T-47D_Human2.15155751
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.08996262
33ESR1_21235772_ChIP-Seq_MCF-7_Human2.06393439
34DROSHA_22980978_ChIP-Seq_HELA_Human2.00292033
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.99453071
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.98757396
37* RXR_22158963_ChIP-Seq_LIVER_Mouse1.94786665
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.89623062
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.86176292
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85422480
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84727840
42AR_21909140_ChIP-Seq_LNCAP_Human1.82352079
43* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.73198258
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68727918
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.64952008
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64935626
47SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.64160974
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.63314906
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62998086
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62395493
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60658005
52TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53839157
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52580919
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52112073
55TAF15_26573619_Chip-Seq_HEK293_Human1.51702251
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50779511
57SOX2_20726797_ChIP-Seq_SW620_Human1.50295029
58* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50193533
59* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50015923
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49978270
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48757479
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48189689
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46328461
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44959074
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44788941
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44217162
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42600846
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42481093
69LXR_22292898_ChIP-Seq_THP-1_Human1.41765946
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41740551
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40701620
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40472702
73ZNF274_21170338_ChIP-Seq_K562_Hela1.39944201
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.36643788
75* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36574662
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.35217602
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34562648
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34255702
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32369011
80ATF3_27146783_Chip-Seq_COLON_Human1.31394721
81MYC_18555785_ChIP-Seq_MESCs_Mouse1.30797598
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30013541
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28260304
84* TET1_21451524_ChIP-Seq_MESCs_Mouse1.28163410
85* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28058450
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26781746
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24086817
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23692313
89LXR_22158963_ChIP-Seq_LIVER_Mouse1.23664653
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22855404
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22478285
92EOMES_21245162_ChIP-Seq_HESCs_Human1.21705786
93SMAD4_21799915_ChIP-Seq_A2780_Human1.21599467
94VDR_22108803_ChIP-Seq_LS180_Human1.20675060
95TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.20575683
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20288684
97* TBX20_22080862_ChIP-Seq_HEART_Mouse1.20206393
98* TBX20_22328084_ChIP-Seq_HEART_Mouse1.20206393
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19777321
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18814938
101NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18667959
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18655027
103STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18099571
104AR_21572438_ChIP-Seq_LNCaP_Human1.17957979
105OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16639319
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16216279
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.16049852
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15763467
109* GATA6_25053715_ChIP-Seq_YYC3_Human1.15568161
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14789362
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.14427014
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14424912
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14170092
114P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13328134
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12675021
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12521254
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.11784288
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11463849
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10461154
120TET1_21490601_ChIP-Seq_MESCs_Mouse1.09375801
121* GATA3_24758297_ChIP-Seq_MCF-7_Human1.07180709
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07001216
123CHD1_26751641_Chip-Seq_LNCaP_Human1.06698164
124SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06532289
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05617531
126TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04872760
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04673415
128ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04117933
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03687069
130SMAD3_21741376_ChIP-Seq_EPCs_Human1.03684473
131P300_19829295_ChIP-Seq_ESCs_Human1.03674751
132STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02929277
133ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02794250
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.02687219
135P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01454499
136SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01404067
137CTCF_27219007_Chip-Seq_Bcells_Human1.01342772
138WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00982168
139MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00709513
140SOX2_21211035_ChIP-Seq_LN229_Gbm1.00663384
141HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00598765
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00292138
143CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99852741
144TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99631436
145RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99481415
146THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99312683
147SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99095566
148SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99095566
149AR_25329375_ChIP-Seq_VCAP_Human0.98604512
150CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97359105
151CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96583495
152HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96060659
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94838185
154BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94530104
155KDM2B_26808549_Chip-Seq_K562_Human0.93790195
156RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93697092
157EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93288754
158STAT3_23295773_ChIP-Seq_U87_Human0.93249154
159ESR2_21235772_ChIP-Seq_MCF-7_Human0.93145805
160SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91976977
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91768378
162AR_19668381_ChIP-Seq_PC3_Human0.86701995
163OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86024133
164SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85010064
165GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83682417
166SMAD4_21741376_ChIP-Seq_HESCs_Human0.83670490
167CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83374119
168MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83204045
169AHR_22903824_ChIP-Seq_MCF-7_Human0.83194449
170NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81798773
171SMAD3_21741376_ChIP-Seq_ESCs_Human0.81716459
172ARNT_22903824_ChIP-Seq_MCF-7_Human0.81557568
173TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81540977
174RUNX2_22187159_ChIP-Seq_PCA_Human0.80840701
175THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80602928
176ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80406912
177GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80372951
178ER_23166858_ChIP-Seq_MCF-7_Human0.80059512
179UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79550744
180VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79399090
181NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78751067
182NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78751067
183RING1B_27294783_Chip-Seq_NPCs_Mouse0.77780120
184AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77113674
185FLI1_21867929_ChIP-Seq_TH2_Mouse0.76936497
186PRDM14_20953172_ChIP-Seq_ESCs_Human0.76204174
187CBX2_27304074_Chip-Seq_ESCs_Mouse0.75815249
188* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75582423
189SMAD4_21741376_ChIP-Seq_EPCs_Human0.75126699
190WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75016672

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.09158559
2MP0003880_abnormal_central_pattern4.34109741
3MP0004270_analgesia3.99877887
4MP0003635_abnormal_synaptic_transmissio3.39996391
5MP0005670_abnormal_white_adipose3.20947241
6MP0003329_amyloid_beta_deposits3.08542938
7MP0010234_abnormal_vibrissa_follicle2.89886938
8MP0002064_seizures2.83446808
9MP0009745_abnormal_behavioral_response2.77617517
10MP0004130_abnormal_muscle_cell2.73433447
11MP0002063_abnormal_learning/memory/cond2.65170077
12MP0003191_abnormal_cellular_cholesterol2.63764526
13MP0001968_abnormal_touch/_nociception2.61975726
14MP0002734_abnormal_mechanical_nocicepti2.55392225
15MP0002272_abnormal_nervous_system2.54956613
16MP0003705_abnormal_hypodermis_morpholog2.54828239
17MP0004185_abnormal_adipocyte_glucose2.41995081
18MP0003566_abnormal_cell_adhesion2.41992943
19MP0009046_muscle_twitch2.40445787
20MP0004233_abnormal_muscle_weight2.24510908
21MP0002572_abnormal_emotion/affect_behav2.22277122
22MP0001486_abnormal_startle_reflex2.19260705
23MP0002735_abnormal_chemical_nociception2.16650741
24MP0002796_impaired_skin_barrier2.15350000
25MP0002733_abnormal_thermal_nociception2.14512776
26MP0004043_abnormal_pH_regulation2.09252868
27MP0000920_abnormal_myelination2.09070398
28MP0004858_abnormal_nervous_system2.03552440
29MP0001440_abnormal_grooming_behavior2.03382641
30MP0002909_abnormal_adrenal_gland2.01547148
31MP0002877_abnormal_melanocyte_morpholog2.00217439
32MP0001970_abnormal_pain_threshold1.99139394
33MP0003941_abnormal_skin_development1.97984274
34MP0002736_abnormal_nociception_after1.96000462
35MP0005257_abnormal_intraocular_pressure1.95582812
36MP0005501_abnormal_skin_physiology1.93211247
37MP0001501_abnormal_sleep_pattern1.93072974
38MP0004885_abnormal_endolymph1.92756530
39MP0003656_abnormal_erythrocyte_physiolo1.91255286
40MP0002822_catalepsy1.86733916
41MP0005423_abnormal_somatic_nervous1.86399818
42MP0009379_abnormal_foot_pigmentation1.84971452
43MP0005666_abnormal_adipose_tissue1.84774419
44MP0008438_abnormal_cutaneous_collagen1.83936167
45MP0005464_abnormal_platelet_physiology1.80682068
46MP0000604_amyloidosis1.79991078
47MP0003186_abnormal_redox_activity1.79293729
48MP0002971_abnormal_brown_adipose1.76288509
49MP0000751_myopathy1.75298594
50MP0001905_abnormal_dopamine_level1.73102324
51MP0009780_abnormal_chondrocyte_physiolo1.70613191
52MP0002067_abnormal_sensory_capabilities1.70434336
53MP0004272_abnormal_basement_membrane1.69273924
54MP0000749_muscle_degeneration1.67537826
55MP0006276_abnormal_autonomic_nervous1.62157214
56MP0004147_increased_porphyrin_level1.57024328
57MP0003690_abnormal_glial_cell1.55734697
58MP0004134_abnormal_chest_morphology1.54603353
59MP0005165_increased_susceptibility_to1.53623405
60MP0003634_abnormal_glial_cell1.53165660
61MP0001529_abnormal_vocalization1.51868842
62MP0000778_abnormal_nervous_system1.50342063
63MP0000343_altered_response_to1.49977356
64MP0004087_abnormal_muscle_fiber1.49602334
65MP0004924_abnormal_behavior1.49098416
66MP0005386_behavior/neurological_phenoty1.49098416
67MP0000013_abnormal_adipose_tissue1.47824064
68MP0000955_abnormal_spinal_cord1.47076833
69MP0006036_abnormal_mitochondrial_physio1.46341360
70MP0005408_hypopigmentation1.46174529
71MP0009053_abnormal_anal_canal1.46019995
72MP0003806_abnormal_nucleotide_metabolis1.43119208
73MP0003633_abnormal_nervous_system1.42359101
74MP0005330_cardiomyopathy1.41377978
75MP0002184_abnormal_innervation1.40819792
76MP0008569_lethality_at_weaning1.40491401
77MP0002229_neurodegeneration1.40405337
78MP0004142_abnormal_muscle_tone1.39096978
79MP0002066_abnormal_motor_capabilities/c1.37941728
80MP0006138_congestive_heart_failure1.37773840
81MP0002557_abnormal_social/conspecific_i1.37112655
82MP0004811_abnormal_neuron_physiology1.34853389
83MP0005377_hearing/vestibular/ear_phenot1.33741182
84MP0003878_abnormal_ear_physiology1.33741182
85MP0001502_abnormal_circadian_rhythm1.33551064
86MP0001984_abnormal_olfaction1.32633578
87MP0003879_abnormal_hair_cell1.32059071
88MP0009250_abnormal_appendicular_skeleto1.30679892
89MP0003195_calcinosis1.30145778
90MP0000759_abnormal_skeletal_muscle1.29476905
91MP0002882_abnormal_neuron_morphology1.29266719
92MP0008004_abnormal_stomach_pH1.28905857
93MP0010386_abnormal_urinary_bladder1.28179873
94MP0004036_abnormal_muscle_relaxation1.26995508
95MP0005058_abnormal_lysosome_morphology1.26513690
96MP0005623_abnormal_meninges_morphology1.24884164
97MP0000750_abnormal_muscle_regeneration1.23946189
98MP0004782_abnormal_surfactant_physiolog1.23740173
99MP0003631_nervous_system_phenotype1.23671725
100MP0004264_abnormal_extraembryonic_tissu1.21440514
101MP0005535_abnormal_body_temperature1.20085620
102MP0003315_abnormal_perineum_morphology1.19747323
103MP0002972_abnormal_cardiac_muscle1.17491463
104MP0004742_abnormal_vestibular_system1.17360602
105MP0005375_adipose_tissue_phenotype1.17204535
106MP0010630_abnormal_cardiac_muscle1.14931332
107MP0000537_abnormal_urethra_morphology1.13793497
108MP0002837_dystrophic_cardiac_calcinosis1.13761189
109MP0010030_abnormal_orbit_morphology1.11562170
110MP0010352_gastrointestinal_tract_polyps1.10452872
111MP0003075_altered_response_to1.09617756
112MP0010329_abnormal_lipoprotein_level1.09586853
113MP0008260_abnormal_autophagy1.09586630
114MP0002896_abnormal_bone_mineralization1.07109697
115MP0003453_abnormal_keratinocyte_physiol1.06404176
116MP0005409_darkened_coat_color1.05892914
117MP0005645_abnormal_hypothalamus_physiol1.04550612
118MP0005646_abnormal_pituitary_gland1.03529069
119MP0005451_abnormal_body_composition1.02949644
120MP0000678_abnormal_parathyroid_gland1.02350624
121MP0001661_extended_life_span1.01852780
122MP0003283_abnormal_digestive_organ1.01240297
123MP0003632_abnormal_nervous_system1.00812210
124MP0005365_abnormal_bile_salt1.00383512
125MP0001666_abnormal_nutrient_absorption0.99060877
126MP0004019_abnormal_vitamin_homeostasis0.98423909
127MP0001765_abnormal_ion_homeostasis0.97451795
128MP0000762_abnormal_tongue_morphology0.96244142
129MP0005551_abnormal_eye_electrophysiolog0.95627679
130MP0001485_abnormal_pinna_reflex0.94869816
131MP0002069_abnormal_eating/drinking_beha0.94639744
132MP0000534_abnormal_ureter_morphology0.93623768
133MP0003172_abnormal_lysosome_physiology0.93368075
134MP0005620_abnormal_muscle_contractility0.92834030
135MP0002090_abnormal_vision0.91954828
136MP0000467_abnormal_esophagus_morphology0.91111225
137MP0003183_abnormal_peptide_metabolism0.89974476
138MP0001664_abnormal_digestion0.89507965
139MP0005410_abnormal_fertilization0.89339169
140MP0003828_pulmonary_edema0.89155057
141MP0002089_abnormal_postnatal_growth/wei0.88492062
142MP0002139_abnormal_hepatobiliary_system0.87112415
143MP0005275_abnormal_skin_tensile0.87084024
144MP0001177_atelectasis0.86831387
145MP0002638_abnormal_pupillary_reflex0.86772567
146MP0005385_cardiovascular_system_phenoty0.85624516
147MP0001544_abnormal_cardiovascular_syste0.85624516
148MP0000747_muscle_weakness0.84356667
149MP0001963_abnormal_hearing_physiology0.83776847
150MP0004145_abnormal_muscle_electrophysio0.83546229
151MP0003638_abnormal_response/metabolism_0.83243415
152MP0002269_muscular_atrophy0.81978118
153MP0002876_abnormal_thyroid_physiology0.81655407
154MP0005584_abnormal_enzyme/coenzyme_acti0.81600881
155MP0002152_abnormal_brain_morphology0.80811569
156MP0001727_abnormal_embryo_implantation0.80264325
157MP0001849_ear_inflammation0.79792096
158MP0001958_emphysema0.78488167
159MP0004215_abnormal_myocardial_fiber0.78077771
160MP0000681_abnormal_thyroid_gland0.77725007
161MP0000858_altered_metastatic_potential0.75551301
162MP0005379_endocrine/exocrine_gland_phen0.75120591
163MP0005360_urolithiasis0.74904718
164MP0002060_abnormal_skin_morphology0.74680415
165MP0002098_abnormal_vibrissa_morphology0.74246262
166MP0005083_abnormal_biliary_tract0.73312449
167MP0001542_abnormal_bone_strength0.73048330
168MP0002752_abnormal_somatic_nervous0.73043312
169MP0009840_abnormal_foam_cell0.71785065
170MP0008874_decreased_physiological_sensi0.71558246
171MP0005332_abnormal_amino_acid0.71472323
172MP0000462_abnormal_digestive_system0.71446895
173MP0001986_abnormal_taste_sensitivity0.68736162
174MP0008961_abnormal_basal_metabolism0.67834978
175MP0002078_abnormal_glucose_homeostasis0.67202698
176MP0000230_abnormal_systemic_arterial0.66483325
177MP0001299_abnormal_eye_distance/0.64323382
178MP0002118_abnormal_lipid_homeostasis0.63638806
179MP0005167_abnormal_blood-brain_barrier0.63010822
180MP0002295_abnormal_pulmonary_circulatio0.62150396
181MP0003122_maternal_imprinting0.60158009
182MP0000003_abnormal_adipose_tissue0.60074001
183MP0008872_abnormal_physiological_respon0.59914925
184MP0005636_abnormal_mineral_homeostasis0.59283584

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.31830820
2Neurofibrillary tangles (HP:0002185)5.12525697
3Focal motor seizures (HP:0011153)4.72076927
4Supranuclear gaze palsy (HP:0000605)4.57555214
5Achilles tendon contracture (HP:0001771)4.40129876
6Cerebral inclusion bodies (HP:0100314)4.32203779
7Abnormality of the Achilles tendon (HP:0005109)4.23543132
8Visual hallucinations (HP:0002367)4.08402484
9Focal seizures (HP:0007359)3.61399010
10Reduced subcutaneous adipose tissue (HP:0003758)3.55518631
11Vertebral compression fractures (HP:0002953)3.52343898
12Atonic seizures (HP:0010819)3.43625346
13Ankle clonus (HP:0011448)3.34912480
14Epileptic encephalopathy (HP:0200134)3.20719628
15Atrioventricular block (HP:0001678)3.17118436
16Pheochromocytoma (HP:0002666)3.16723664
17Action tremor (HP:0002345)3.11826857
18Abnormal atrioventricular conduction (HP:0005150)3.09579632
19Rhabdomyolysis (HP:0003201)3.06352356
20Retinal dysplasia (HP:0007973)2.96855082
21Distal lower limb muscle weakness (HP:0009053)2.95869773
22Hyporeflexia of lower limbs (HP:0002600)2.94876405
23Dysmetria (HP:0001310)2.93662940
24Heart block (HP:0012722)2.90523809
25Exercise-induced myalgia (HP:0003738)2.89314638
26Right ventricular cardiomyopathy (HP:0011663)2.88063526
27Absence seizures (HP:0002121)2.83850814
28Nemaline bodies (HP:0003798)2.77805899
29Protrusio acetabuli (HP:0003179)2.77219198
30Muscle fiber inclusion bodies (HP:0100299)2.76895959
31Dialeptic seizures (HP:0011146)2.76783339
32Neuroendocrine neoplasm (HP:0100634)2.76450297
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.75092819
34Trismus (HP:0000211)2.75052954
35Intention tremor (HP:0002080)2.73958816
36Anxiety (HP:0000739)2.73639327
37Spastic gait (HP:0002064)2.72295389
38Vascular calcification (HP:0004934)2.71774381
39Bundle branch block (HP:0011710)2.71453616
40Generalized tonic-clonic seizures (HP:0002069)2.70573314
41Type 1 muscle fiber predominance (HP:0003803)2.69043794
42Increased circulating renin level (HP:0000848)2.68781566
43Peripheral hypomyelination (HP:0007182)2.67657437
44Gout (HP:0001997)2.65904489
45Cardiovascular calcification (HP:0011915)2.60927228
46Myoglobinuria (HP:0002913)2.60366413
47Abnormal eating behavior (HP:0100738)2.60137103
48Abnormality of the corticospinal tract (HP:0002492)2.56474530
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54988077
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.54988077
51Depression (HP:0000716)2.54053922
52Elbow flexion contracture (HP:0002987)2.53239195
53Mutism (HP:0002300)2.52968013
54Megalencephaly (HP:0001355)2.52130697
55Premature rupture of membranes (HP:0001788)2.51876409
56Axonal loss (HP:0003447)2.50887899
57Myopathic facies (HP:0002058)2.48908761
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.48411519
59Ventricular tachycardia (HP:0004756)2.47756273
60Increased connective tissue (HP:0009025)2.44982854
61Delusions (HP:0000746)2.44901215
62Progressive cerebellar ataxia (HP:0002073)2.43886566
63Hypokalemic alkalosis (HP:0001949)2.43135016
64Abnormality of the nasal mucosa (HP:0000433)2.41418308
65Ileus (HP:0002595)2.41135875
66Increased serum pyruvate (HP:0003542)2.41013547
67Type II lissencephaly (HP:0007260)2.40810911
68Scanning speech (HP:0002168)2.39929518
69Hyperparathyroidism (HP:0000843)2.39171785
70Truncal ataxia (HP:0002078)2.34879196
71Insidious onset (HP:0003587)2.31457777
72Termporal pattern (HP:0011008)2.31457777
73Vacuolated lymphocytes (HP:0001922)2.29895305
74Hyperactive renin-angiotensin system (HP:0000841)2.28109938
75Osteolytic defects of the hand bones (HP:0009699)2.25822244
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.25822244
77Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25567743
78Akinesia (HP:0002304)2.25442952
79Nasal polyposis (HP:0100582)2.24944991
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24929345
81Polyphagia (HP:0002591)2.24865328
82Postural instability (HP:0002172)2.22357248
83Abnormality of skeletal muscle fiber size (HP:0012084)2.21027610
84Abnormality of magnesium homeostasis (HP:0004921)2.20348295
85Progressive inability to walk (HP:0002505)2.18778096
86Paralysis (HP:0003470)2.18599926
87Epileptiform EEG discharges (HP:0011182)2.17792246
88EEG with generalized epileptiform discharges (HP:0011198)2.17653240
89Hydroxyprolinuria (HP:0003080)2.17525185
90Abnormality of proline metabolism (HP:0010907)2.17525185
91Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16615492
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16615492
93Limb dystonia (HP:0002451)2.16342743
94Cerebral hemorrhage (HP:0001342)2.16095492
95Urinary urgency (HP:0000012)2.15131705
96Hypertriglyceridemia (HP:0002155)2.13659453
97Rigidity (HP:0002063)2.12814889
98Scapular winging (HP:0003691)2.12763540
99Torticollis (HP:0000473)2.11236450
100Increased variability in muscle fiber diameter (HP:0003557)2.10391164
101Hypsarrhythmia (HP:0002521)2.09105453
102Abnormality of glycolysis (HP:0004366)2.08375007
103Neuronal loss in central nervous system (HP:0002529)2.08306867
104Hypomagnesemia (HP:0002917)2.07102694
105Clonus (HP:0002169)2.06396976
106Poor eye contact (HP:0000817)2.06252174
107Spinal rigidity (HP:0003306)2.06206851
108Lipoatrophy (HP:0100578)2.05976717
109Cerebral hypomyelination (HP:0006808)2.05000799
110Muscle stiffness (HP:0003552)2.04101307
111Metabolic alkalosis (HP:0200114)2.04070558
112Lower limb muscle weakness (HP:0007340)2.03969735
113Split foot (HP:0001839)2.03262661
114Febrile seizures (HP:0002373)2.02882090
115Focal dystonia (HP:0004373)2.02865991
116Dysdiadochokinesis (HP:0002075)2.02589139
117Bradykinesia (HP:0002067)2.01053615
118Rapidly progressive (HP:0003678)2.00474328
119Abnormality of the distal phalanges of the toes (HP:0010182)1.99544528
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99409978
121Neck muscle weakness (HP:0000467)1.98549007
122Renal salt wasting (HP:0000127)1.97699914
123Sudden death (HP:0001699)1.95706311
124Generalized myoclonic seizures (HP:0002123)1.95327695
125Short nail (HP:0001799)1.95145765
126Hyperventilation (HP:0002883)1.94562211
127Abnormality of glycolipid metabolism (HP:0010969)1.94391665
128Abnormality of liposaccharide metabolism (HP:0010968)1.94391665
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.94391665
130Amblyopia (HP:0000646)1.93559576
131Thickened helices (HP:0000391)1.91986273
132Craniofacial dystonia (HP:0012179)1.91413253
133Abnormal social behavior (HP:0012433)1.91378394
134Impaired social interactions (HP:0000735)1.91378394
135Psychosis (HP:0000709)1.91144544
136Hyperaldosteronism (HP:0000859)1.91003502
137Beaking of vertebral bodies (HP:0004568)1.90647457
138Hemiparesis (HP:0001269)1.90026929
139Ragged-red muscle fibers (HP:0003200)1.89205098
140EMG: myopathic abnormalities (HP:0003458)1.89152432
141Distal lower limb amyotrophy (HP:0008944)1.89037025
142Dysostosis multiplex (HP:0000943)1.88420959
143Flat acetabular roof (HP:0003180)1.88362622
144Increased mean platelet volume (HP:0011877)1.88237035
145Progressive muscle weakness (HP:0003323)1.88120780
146Menorrhagia (HP:0000132)1.87688080
147Gaze-evoked nystagmus (HP:0000640)1.87103368
148Pathologic fracture (HP:0002756)1.87063552
149Dilated cardiomyopathy (HP:0001644)1.86765012
150Spastic tetraparesis (HP:0001285)1.86228877
151Ventricular arrhythmia (HP:0004308)1.84523612
152Abnormality of renin-angiotensin system (HP:0000847)1.84170611
153Papilledema (HP:0001085)1.83960001
154Asymmetric septal hypertrophy (HP:0001670)1.83229273
155Hyperammonemia (HP:0001987)1.82589198
156Broad-based gait (HP:0002136)1.82566239
157Ventricular fibrillation (HP:0001663)1.81724074
158Impaired vibration sensation in the lower limbs (HP:0002166)1.81037244
159Abnormality of the umbilical cord (HP:0010881)1.79131156
160Sensory axonal neuropathy (HP:0003390)1.78827557
161Hyperphosphatemia (HP:0002905)1.78730679
162Bone pain (HP:0002653)1.78658131
163Abnormal gallbladder physiology (HP:0012438)1.78375054
164Cholecystitis (HP:0001082)1.78375054
165Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78079217
166Cervical subluxation (HP:0003308)1.77830264
167Onion bulb formation (HP:0003383)1.77229156
168Back pain (HP:0003418)1.76851236
169Urinary bladder sphincter dysfunction (HP:0002839)1.76070054
170Polycythemia (HP:0001901)1.75917354
171Global brain atrophy (HP:0002283)1.75497146
172Ketoacidosis (HP:0001993)1.74314292
173Increased muscle lipid content (HP:0009058)1.74281984
174Resting tremor (HP:0002322)1.73907576
175Sparse eyelashes (HP:0000653)1.73631439
176Clumsiness (HP:0002312)1.72867853
177Purpura (HP:0000979)1.72650883
178Agitation (HP:0000713)1.72076833
179Tetraparesis (HP:0002273)1.71472770
180Skin nodule (HP:0200036)1.71445518
181Abnormality of the fetal cardiovascular system (HP:0010948)1.70689031
182Abnormal umbilical cord blood vessels (HP:0011403)1.70689031
183Single umbilical artery (HP:0001195)1.70689031
184Vascular tortuosity (HP:0004948)1.70415347
185Shawl scrotum (HP:0000049)1.69823614
186Renal tubular acidosis (HP:0001947)1.68359763
187Xanthomatosis (HP:0000991)1.67988025
188Chronic otitis media (HP:0000389)1.67313183
189Abnormal cartilage morphology (HP:0002763)1.66080691
190Abnormality of the acetabulum (HP:0003170)1.64344650
191Tetraplegia (HP:0002445)1.64115142
192Abnormality of the heme biosynthetic pathway (HP:0010472)1.63910150
193Ulnar deviation of the wrist (HP:0003049)1.63526451
194Hyperthyroidism (HP:0000836)1.62543007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.59544690
2EPHA43.51627495
3EIF2AK13.28726801
4NTRK33.06631971
5TESK12.93080537
6MYLK2.92570814
7EPHA22.86305362
8NTRK12.81541683
9ARAF2.76982731
10KSR22.75537289
11MST1R2.64269821
12TRIB32.63920696
13STK392.63040900
14OXSR12.50980748
15MARK12.36261402
16DAPK22.20578112
17PAK62.17603455
18TGFBR22.16996813
19RIPK42.16286324
20MINK12.14956818
21WNK42.09275777
22PRKD31.97293756
23DMPK1.88884671
24PDK21.86641420
25NME21.84997083
26MAP3K41.83300632
27PBK1.81827928
28MAP3K21.69196162
29TTN1.67052773
30CAMKK21.64018953
31MOS1.63931134
32CDK191.62957934
33MAP2K71.60022512
34PRKD21.59826671
35OBSCN1.59364654
36TESK21.55112681
37GRK71.54854455
38RIPK11.45586578
39PAK41.44270710
40MAP3K121.42309055
41SIK11.41895303
42CDK51.40598748
43MAP3K131.38417278
44UHMK11.38304482
45KSR11.37916795
46PNCK1.36593532
47GRK51.34365936
48PIK3CA1.28900945
49LIMK11.27654495
50IRAK31.27115263
51CAMKK11.24816739
52WNK31.23791845
53LRRK21.23159260
54BCR1.21407445
55EPHB21.21216696
56BMX1.20909422
57ILK1.20595146
58MAPKAPK31.20056014
59MAP2K41.19991641
60CAMK2B1.19353400
61PRPF4B1.18698438
62SGK4941.15004321
63SGK2231.15004321
64LATS21.13542340
65NEK11.10312059
66NTRK21.09553163
67CSNK1G21.09189186
68PINK11.09018734
69PKN21.08621903
70PHKG21.08342056
71PHKG11.08342056
72TNIK1.07865394
73MAP2K31.06232484
74PAK31.05083760
75PRKCG0.98182599
76SMG10.97490487
77CDK140.96849732
78TYRO30.96266745
79CAMK2A0.95381221
80MAP3K10.94760551
81PDPK10.93969956
82CAMK2G0.92368602
83CAMK2D0.89603956
84CSNK1G30.88846251
85MAP3K30.88497098
86MET0.87722613
87ERN10.86544212
88NME10.86403835
89PRKCH0.86304727
90WNK10.85977255
91PDGFRA0.85871992
92DAPK10.85195789
93PLK20.84184069
94PTK2B0.83638551
95BRAF0.83535626
96MAPKAPK50.83111862
97CDK180.82294822
98PAK10.82251144
99CDK150.81713956
100PTK60.79758137
101FGR0.79156071
102TAOK20.76843035
103RAF10.76608330
104CASK0.74975094
105MAPK150.74720386
106FGFR20.74155550
107MST40.73694440
108LMTK20.72075495
109MAP3K110.71617524
110STK160.71604813
111RET0.70829991
112BMPR20.70527965
113EPHB10.70312463
114CDK11A0.69816057
115MAP2K10.66826721
116PDK10.66503768
117ERBB40.64228490
118PRKD10.64075103
119BRSK10.63923865
120PRKCE0.63604996
121AURKA0.63236972
122MAPK130.62620330
123NEK60.62522563
124RPS6KA20.62256413
125MAP3K50.61508351
126CSNK1A1L0.60592022
127ROCK20.60488300
128PAK20.60045450
129PKN10.59647822
130PIM20.58230007
131FES0.57256218
132STK100.57199058
133ICK0.56412723
134DYRK30.56149577
135PRKG20.55575545
136PRKCZ0.55239857
137STK380.54234485
138AKT20.53233481
139PRKAA20.53201948
140CSNK1G10.52203374
141DYRK1A0.52041151
142MUSK0.50295663
143VRK20.49545478
144MAPK120.49448391
145NEK90.49014514
146MAPKAPK20.48878303
147MARK20.46596697
148FER0.45289397
149STK110.44254763
150CAMK10.43959172
151DAPK30.43733851
152BRSK20.42963996
153MAP3K60.42279758
154DYRK20.41976253
155TAOK10.41588960
156FYN0.41193983
157SGK30.40233647
158INSRR0.40229786
159BUB10.38608124
160PTK20.38164656
161MTOR0.38019083
162SCYL20.37222192
163CAMK1G0.37069091
164PRKCI0.36689012
165ABL20.35862284
166PRKCD0.31644181

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.30917937
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.66886381
3Collecting duct acid secretion_Homo sapiens_hsa049662.57872345
4Nicotine addiction_Homo sapiens_hsa050332.47466945
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36978309
6GABAergic synapse_Homo sapiens_hsa047272.31491829
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08238802
8PPAR signaling pathway_Homo sapiens_hsa033201.97881094
9Insulin secretion_Homo sapiens_hsa049111.97166894
10Circadian entrainment_Homo sapiens_hsa047131.97111563
11Long-term potentiation_Homo sapiens_hsa047201.95201239
12Glutamatergic synapse_Homo sapiens_hsa047241.94712823
13Galactose metabolism_Homo sapiens_hsa000521.94496759
14Morphine addiction_Homo sapiens_hsa050321.91117010
15Fatty acid metabolism_Homo sapiens_hsa012121.89362517
16Vibrio cholerae infection_Homo sapiens_hsa051101.88491941
17Amphetamine addiction_Homo sapiens_hsa050311.84491198
18Phenylalanine metabolism_Homo sapiens_hsa003601.84458066
19Olfactory transduction_Homo sapiens_hsa047401.79051331
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74834563
21beta-Alanine metabolism_Homo sapiens_hsa004101.72897138
22Dopaminergic synapse_Homo sapiens_hsa047281.72090897
23Salivary secretion_Homo sapiens_hsa049701.68259953
24Arginine and proline metabolism_Homo sapiens_hsa003301.66626105
25Oxidative phosphorylation_Homo sapiens_hsa001901.63243333
26Pentose phosphate pathway_Homo sapiens_hsa000301.60782083
27Fatty acid degradation_Homo sapiens_hsa000711.58497111
28Fat digestion and absorption_Homo sapiens_hsa049751.58427758
29Gastric acid secretion_Homo sapiens_hsa049711.56860580
30Carbon metabolism_Homo sapiens_hsa012001.52550089
31Dilated cardiomyopathy_Homo sapiens_hsa054141.50744815
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49522828
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49495904
34Cocaine addiction_Homo sapiens_hsa050301.49139635
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48740341
36Histidine metabolism_Homo sapiens_hsa003401.48299907
37Taste transduction_Homo sapiens_hsa047421.47765053
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47325206
39Serotonergic synapse_Homo sapiens_hsa047261.45606352
40Cholinergic synapse_Homo sapiens_hsa047251.45208879
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.31030564
42Long-term depression_Homo sapiens_hsa047301.27353976
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26431390
44ECM-receptor interaction_Homo sapiens_hsa045121.25689408
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21939678
46Alzheimers disease_Homo sapiens_hsa050101.21298119
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20129963
48Tyrosine metabolism_Homo sapiens_hsa003501.20018104
49Biosynthesis of amino acids_Homo sapiens_hsa012301.19850088
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19371276
51Renin secretion_Homo sapiens_hsa049241.19022784
52Other glycan degradation_Homo sapiens_hsa005111.15358916
53Lysosome_Homo sapiens_hsa041421.13421716
54Parkinsons disease_Homo sapiens_hsa050121.13411938
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13260274
56Folate biosynthesis_Homo sapiens_hsa007901.12367223
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11126211
58Cardiac muscle contraction_Homo sapiens_hsa042601.09499870
59Starch and sucrose metabolism_Homo sapiens_hsa005001.08350772
60Sulfur metabolism_Homo sapiens_hsa009201.08133732
61Glutathione metabolism_Homo sapiens_hsa004801.07901553
62Sulfur relay system_Homo sapiens_hsa041221.06833356
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06563189
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06552609
65Fructose and mannose metabolism_Homo sapiens_hsa000511.06189721
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04828203
67Butanoate metabolism_Homo sapiens_hsa006501.03837946
68Pancreatic secretion_Homo sapiens_hsa049721.01605041
69Arginine biosynthesis_Homo sapiens_hsa002201.01416258
70Nitrogen metabolism_Homo sapiens_hsa009101.00186731
71Oxytocin signaling pathway_Homo sapiens_hsa049210.99691131
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97809360
73Fatty acid elongation_Homo sapiens_hsa000620.96801889
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96381106
75GnRH signaling pathway_Homo sapiens_hsa049120.95529177
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95239484
77Calcium signaling pathway_Homo sapiens_hsa040200.94445812
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93635492
79Gap junction_Homo sapiens_hsa045400.93232614
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92922773
81Thyroid cancer_Homo sapiens_hsa052160.92020463
82Mineral absorption_Homo sapiens_hsa049780.91993740
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91511794
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.90052961
85Type II diabetes mellitus_Homo sapiens_hsa049300.89328294
86AMPK signaling pathway_Homo sapiens_hsa041520.88898830
87Thyroid hormone synthesis_Homo sapiens_hsa049180.88344738
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88242829
89Renin-angiotensin system_Homo sapiens_hsa046140.87230178
90Proteasome_Homo sapiens_hsa030500.85838495
91Vitamin digestion and absorption_Homo sapiens_hsa049770.84000468
92Axon guidance_Homo sapiens_hsa043600.83742841
93Regulation of autophagy_Homo sapiens_hsa041400.83691023
94N-Glycan biosynthesis_Homo sapiens_hsa005100.83461859
95cAMP signaling pathway_Homo sapiens_hsa040240.82253638
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80877845
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.80626397
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80230964
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79516629
100Estrogen signaling pathway_Homo sapiens_hsa049150.77380545
101Prion diseases_Homo sapiens_hsa050200.76562318
102Focal adhesion_Homo sapiens_hsa045100.76071451
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75415857
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74805632
105Ether lipid metabolism_Homo sapiens_hsa005650.74310407
106Rheumatoid arthritis_Homo sapiens_hsa053230.73564499
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73463012
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72140074
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.72070109
110Steroid biosynthesis_Homo sapiens_hsa001000.71621252
111Tight junction_Homo sapiens_hsa045300.71590849
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71493615
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68797344
114Protein export_Homo sapiens_hsa030600.68639346
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68095762
116Vitamin B6 metabolism_Homo sapiens_hsa007500.67108204
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.66610208
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.66593755
119Insulin signaling pathway_Homo sapiens_hsa049100.66231140
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65803866
121Endocytosis_Homo sapiens_hsa041440.64274366
122Dorso-ventral axis formation_Homo sapiens_hsa043200.63767211
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63253055
124Bile secretion_Homo sapiens_hsa049760.62357335
125Melanogenesis_Homo sapiens_hsa049160.61557061
126Sphingolipid metabolism_Homo sapiens_hsa006000.61521177
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61259305
128Huntingtons disease_Homo sapiens_hsa050160.61215871
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.59983606
130Protein digestion and absorption_Homo sapiens_hsa049740.58831348
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58504755
132ErbB signaling pathway_Homo sapiens_hsa040120.57614195
133Phagosome_Homo sapiens_hsa041450.56244152
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53153776
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52919053
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52836786
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.52496558
138Renal cell carcinoma_Homo sapiens_hsa052110.51604002
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51075716
140Choline metabolism in cancer_Homo sapiens_hsa052310.50338898
141Glioma_Homo sapiens_hsa052140.49878749
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45929711
143Proteoglycans in cancer_Homo sapiens_hsa052050.45678032
144VEGF signaling pathway_Homo sapiens_hsa043700.45295489
145Ribosome_Homo sapiens_hsa030100.44739705
146Peroxisome_Homo sapiens_hsa041460.44532809
147Glycerolipid metabolism_Homo sapiens_hsa005610.43191560
148Metabolic pathways_Homo sapiens_hsa011000.42877276
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42244974
150Phototransduction_Homo sapiens_hsa047440.39085252
151Adherens junction_Homo sapiens_hsa045200.38956174
152Type I diabetes mellitus_Homo sapiens_hsa049400.38657689
153Bladder cancer_Homo sapiens_hsa052190.38555227
154Pyruvate metabolism_Homo sapiens_hsa006200.37277317
155Ras signaling pathway_Homo sapiens_hsa040140.37163610
156Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36881042
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.35924248
158Fatty acid biosynthesis_Homo sapiens_hsa000610.35835410
159Inositol phosphate metabolism_Homo sapiens_hsa005620.35108053
160Oocyte meiosis_Homo sapiens_hsa041140.35099780
161Propanoate metabolism_Homo sapiens_hsa006400.34425393
162Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33305404
163Glucagon signaling pathway_Homo sapiens_hsa049220.33142696

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