GDF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)5.00507766
2sodium ion export (GO:0071436)4.99279715
3cellular potassium ion homeostasis (GO:0030007)4.79989321
4cell differentiation involved in metanephros development (GO:0072202)4.63343650
5gamma-aminobutyric acid transport (GO:0015812)4.59337462
6metanephric mesenchyme development (GO:0072075)4.42340517
7mesenchymal cell differentiation involved in renal system development (GO:2001012)4.26573052
8mesenchymal cell differentiation involved in kidney development (GO:0072161)4.26573052
9cellular sodium ion homeostasis (GO:0006883)4.23670875
10locomotory exploration behavior (GO:0035641)4.04680603
11response to pheromone (GO:0019236)4.02401767
12kidney mesenchyme development (GO:0072074)3.85951874
13extracellular fibril organization (GO:0043206)3.81658761
14skin morphogenesis (GO:0043589)3.75241207
15diaphragm development (GO:0060539)3.74656776
16lung vasculature development (GO:0060426)3.69104861
17C4-dicarboxylate transport (GO:0015740)3.57084457
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.56170175
19potassium ion import (GO:0010107)3.52002359
20cell communication by electrical coupling (GO:0010644)3.45676167
21neuron projection extension involved in neuron projection guidance (GO:1902284)3.42081033
22axon extension involved in axon guidance (GO:0048846)3.42081033
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34545076
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.32101916
25neuron recognition (GO:0008038)3.31825127
26cell migration involved in heart development (GO:0060973)3.31091797
27blood vessel maturation (GO:0001955)3.28031251
28cell differentiation in hindbrain (GO:0021533)3.27233546
29potassium ion homeostasis (GO:0055075)3.26606172
30keratan sulfate catabolic process (GO:0042340)3.23907862
31cerebellar Purkinje cell differentiation (GO:0021702)3.19896789
32regulation of axon extension involved in axon guidance (GO:0048841)3.19035231
33endothelial cell chemotaxis (GO:0035767)3.18140358
34protein heterotrimerization (GO:0070208)3.17641299
35respiratory tube development (GO:0030323)3.16675489
36collagen fibril organization (GO:0030199)3.13255961
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.11908598
38myelination in peripheral nervous system (GO:0022011)3.10687971
39peripheral nervous system axon ensheathment (GO:0032292)3.10687971
40fibril organization (GO:0097435)3.09809477
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08738719
42axon extension (GO:0048675)3.04448162
43glomerulus development (GO:0032835)3.04314533
44paraxial mesoderm development (GO:0048339)3.00795902
45venous blood vessel morphogenesis (GO:0048845)2.99551103
46vocalization behavior (GO:0071625)2.97320143
47glutamate receptor signaling pathway (GO:0007215)2.95097788
48layer formation in cerebral cortex (GO:0021819)2.94848879
49cell differentiation involved in kidney development (GO:0061005)2.94334007
50embryonic retina morphogenesis in camera-type eye (GO:0060059)2.93046805
51cartilage condensation (GO:0001502)2.92925554
52cell aggregation (GO:0098743)2.92925554
53positive regulation of synapse maturation (GO:0090129)2.92903782
54suckling behavior (GO:0001967)2.92017268
55ionotropic glutamate receptor signaling pathway (GO:0035235)2.88797051
56regulation of axon guidance (GO:1902667)2.88403956
57glomerular visceral epithelial cell development (GO:0072015)2.87646369
58negative regulation of catenin import into nucleus (GO:0035414)2.86990666
59cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.86644239
60camera-type eye morphogenesis (GO:0048593)2.84367056
61growth hormone secretion (GO:0030252)2.84343541
62dendrite morphogenesis (GO:0048813)2.83793588
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81852238
64negative regulation of vascular permeability (GO:0043116)2.81562614
65cell migration in hindbrain (GO:0021535)2.78298604
66sodium ion homeostasis (GO:0055078)2.77226617
67presynaptic membrane organization (GO:0097090)2.77074506
68alanine transport (GO:0032328)2.76810949
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76489710
70chondrocyte development (GO:0002063)2.76480038
71regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.76379990
72neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.76235328
73establishment of tissue polarity (GO:0007164)2.75850150
74establishment of planar polarity (GO:0001736)2.75850150
75regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74877238
76synaptic vesicle maturation (GO:0016188)2.73830825
77presynaptic membrane assembly (GO:0097105)2.72802560
78mesenchymal-epithelial cell signaling (GO:0060638)2.72630665
79postsynaptic membrane organization (GO:0001941)2.72187784
80regulation of vascular permeability (GO:0043114)2.71056861
81mesenchyme morphogenesis (GO:0072132)2.70429741
82neurotransmitter secretion (GO:0007269)2.70148816
83cellular response to cholesterol (GO:0071397)2.69200307
84neuronal action potential propagation (GO:0019227)2.68188280
85cAMP biosynthetic process (GO:0006171)2.65310221
86auditory behavior (GO:0031223)2.64612911
87central nervous system projection neuron axonogenesis (GO:0021952)2.63838106
88mating behavior (GO:0007617)2.63797011
89establishment of nucleus localization (GO:0040023)2.63763284
90negative regulation of cartilage development (GO:0061037)2.63213293
91barbed-end actin filament capping (GO:0051016)2.62806034
92positive regulation of gastrulation (GO:2000543)2.62673651
93glomerular basement membrane development (GO:0032836)2.61201435
94establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.59813716
95exploration behavior (GO:0035640)2.57678689
96vascular endothelial growth factor signaling pathway (GO:0038084)2.56455755
97regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.56279390
98astrocyte development (GO:0014002)2.56100028
99apical protein localization (GO:0045176)2.55779636
100metanephric tubule development (GO:0072170)2.55388973
101metanephric nephron tubule development (GO:0072234)2.55388973
102positive regulation of vascular permeability (GO:0043117)2.54267898
103regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54157245
104glomerular epithelial cell development (GO:0072310)2.53929868
105synaptic transmission, glutamatergic (GO:0035249)2.52681882
106cellular response to catecholamine stimulus (GO:0071870)2.52075220
107cellular response to monoamine stimulus (GO:0071868)2.52075220
108Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.51711979
109Notch signaling involved in heart development (GO:0061314)2.51025478
110neuron projection extension (GO:1990138)2.50472077
111cell proliferation involved in metanephros development (GO:0072203)2.49858077
112lateral sprouting from an epithelium (GO:0060601)2.48582016
113neuron remodeling (GO:0016322)2.48081002
114dendritic spine morphogenesis (GO:0060997)2.48043835
115eye morphogenesis (GO:0048592)2.47334778
116negative regulation of hormone metabolic process (GO:0032351)2.46981804
117negative regulation of hormone biosynthetic process (GO:0032353)2.46981804
118cellular response to sterol (GO:0036315)2.46253811
119proline transport (GO:0015824)2.46125833
120cell migration involved in sprouting angiogenesis (GO:0002042)2.46051654
121mesenchymal cell differentiation (GO:0048762)2.45016637
122endothelial cell morphogenesis (GO:0001886)2.44790250
123endocardial cushion morphogenesis (GO:0003203)2.43274537
124pyrimidine nucleobase catabolic process (GO:0006208)2.43072852
125surfactant homeostasis (GO:0043129)2.42898255
126bone trabecula formation (GO:0060346)2.42561228
127cochlea morphogenesis (GO:0090103)2.42295581
128regulation of establishment of planar polarity (GO:0090175)2.40631831
129aorta morphogenesis (GO:0035909)2.40537267
130protein targeting to plasma membrane (GO:0072661)2.39902884
131middle ear morphogenesis (GO:0042474)2.39737912
132negative regulation of sodium ion transport (GO:0010766)2.38827025
133neuromuscular process controlling balance (GO:0050885)2.38669409
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.38266567
135negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.37855244
136glutamate secretion (GO:0014047)2.37522927
137dermatan sulfate biosynthetic process (GO:0030208)2.37474552
138ovulation cycle (GO:0042698)2.37191168
139regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.36380117
140axonal fasciculation (GO:0007413)2.35870590
141positive regulation of macrophage cytokine production (GO:0060907)2.35225883
142inositol phosphate-mediated signaling (GO:0048016)2.35189745
143extracellular matrix assembly (GO:0085029)2.34886926
144collagen metabolic process (GO:0032963)2.34312317
145collagen catabolic process (GO:0030574)2.33949898
146multicellular organismal macromolecule metabolic process (GO:0044259)2.31074728
147peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.30294312
148regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29251819
149sequestering of extracellular ligand from receptor (GO:0035581)2.28208217
150glycine transport (GO:0015816)2.27816190
151neuromuscular junction development (GO:0007528)2.24065523
152long-term memory (GO:0007616)2.23084909
153multicellular organismal catabolic process (GO:0044243)2.20621790
154relaxation of cardiac muscle (GO:0055119)2.18691536
155negative regulation of chondrocyte differentiation (GO:0032331)2.18643004
156multicellular organismal metabolic process (GO:0044236)2.18330798
157neuronal ion channel clustering (GO:0045161)2.17045866
158skeletal muscle organ development (GO:0060538)2.16823742
159neurotransmitter-gated ion channel clustering (GO:0072578)2.16400217
160craniofacial suture morphogenesis (GO:0097094)2.16325075
161regulation of glutamate receptor signaling pathway (GO:1900449)2.15222781
162dermatan sulfate metabolic process (GO:0030205)2.15214641
163response to auditory stimulus (GO:0010996)2.15161527
164G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.14800091
165non-canonical Wnt signaling pathway (GO:0035567)2.14636959
166synaptic vesicle exocytosis (GO:0016079)2.14480713
167activation of protein kinase A activity (GO:0034199)2.14381270
168chondrocyte proliferation (GO:0035988)2.14369569
169cell communication involved in cardiac conduction (GO:0086065)2.13882373
170cytoskeletal anchoring at plasma membrane (GO:0007016)2.13193172
171planar cell polarity pathway involved in neural tube closure (GO:0090179)2.12356916
172lung epithelium development (GO:0060428)2.11161584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.53018805
2EZH2_22144423_ChIP-Seq_EOC_Human3.67664116
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95040882
4* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73781603
5* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73781603
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.69450013
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62349084
8* EED_16625203_ChIP-ChIP_MESCs_Mouse2.59911415
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58090576
10* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57043429
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49062654
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41058938
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39700985
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35770894
15DROSHA_22980978_ChIP-Seq_HELA_Human2.17460766
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.15177626
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08118509
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05614546
19AR_21572438_ChIP-Seq_LNCaP_Human2.02867214
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.02866860
21* EZH2_27294783_Chip-Seq_ESCs_Mouse1.95709613
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88044947
23* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86372926
24* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81865210
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81510822
26GBX2_23144817_ChIP-Seq_PC3_Human1.79347374
27* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76547153
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73995037
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.69269544
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67469697
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.64168748
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61703943
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59512310
34* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58693962
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58226257
36* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56425006
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47231112
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47181637
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44963470
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40315436
41KDM2B_26808549_Chip-Seq_K562_Human1.39114218
42CLOCK_20551151_ChIP-Seq_293T_Human1.38813227
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.38732392
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.37268315
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.36446109
46OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32201029
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29675503
48REST_21632747_ChIP-Seq_MESCs_Mouse1.29294767
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.27326640
50RXR_22108803_ChIP-Seq_LS180_Human1.26400770
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24426631
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.23119291
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20588110
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20090534
55* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19446454
56* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19419187
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.17299640
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15520053
59AR_19668381_ChIP-Seq_PC3_Human1.15411172
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14747000
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14115106
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.13515805
63RNF2_27304074_Chip-Seq_NSC_Mouse1.13361790
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11979824
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11231326
66SMAD4_21799915_ChIP-Seq_A2780_Human1.10931496
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09874880
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09827215
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.09482066
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09227465
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08934283
72TP53_16413492_ChIP-PET_HCT116_Human1.08637288
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07708869
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07367647
75TP53_18474530_ChIP-ChIP_U2OS_Human1.06935252
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05030611
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03760989
78PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03217371
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.02921303
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02836447
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02013017
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.01830288
83AHR_22903824_ChIP-Seq_MCF-7_Human1.00453957
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00267270
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00099842
86TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99694252
87SA1_22415368_ChIP-Seq_MEFs_Mouse0.99643481
88SMAD4_21741376_ChIP-Seq_HESCs_Human0.99609302
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99470815
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99005416
91REST_18959480_ChIP-ChIP_MESCs_Mouse0.98728066
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97677217
93BCAT_22108803_ChIP-Seq_LS180_Human0.97349792
94CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96953619
95RARB_27405468_Chip-Seq_BRAIN_Mouse0.95445663
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95211047
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.95206290
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95077258
99TAF15_26573619_Chip-Seq_HEK293_Human0.94851944
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94755415
101ISL1_27105846_Chip-Seq_CPCs_Mouse0.93639907
102SMAD3_21741376_ChIP-Seq_EPCs_Human0.93519213
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93305246
104ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92617883
105AR_25329375_ChIP-Seq_VCAP_Human0.91866918
106CJUN_26792858_Chip-Seq_BT549_Human0.91791412
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91597835
108NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91301243
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91301243
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91016161
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90848159
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90713489
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90635831
114ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90242234
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89793411
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89196084
117* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89187437
118SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88881122
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88662202
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.88069408
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87021419
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86123482
123FOXA2_19822575_ChIP-Seq_HepG2_Human0.85771656
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85285654
125KDM2B_26808549_Chip-Seq_REH_Human0.84693148
126ZNF274_21170338_ChIP-Seq_K562_Hela0.84129029
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83951977
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82824437
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82011822
130LXR_22158963_ChIP-Seq_LIVER_Mouse0.81831289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.63331808
2MP0008438_abnormal_cutaneous_collagen3.38374063
3MP0004859_abnormal_synaptic_plasticity2.97165976
4MP0005275_abnormal_skin_tensile2.72829577
5MP0009046_muscle_twitch2.57995083
6MP0003283_abnormal_digestive_organ2.55844401
7MP0009780_abnormal_chondrocyte_physiolo2.37801944
8MP0002877_abnormal_melanocyte_morpholog2.29561830
9MP0003635_abnormal_synaptic_transmissio2.23893196
10MP0004272_abnormal_basement_membrane2.17287956
11MP0005187_abnormal_penis_morphology2.15677971
12MP0008569_lethality_at_weaning2.14641738
13MP0004885_abnormal_endolymph2.13160438
14MP0004134_abnormal_chest_morphology2.07950003
15MP0001542_abnormal_bone_strength2.02555641
16MP0001299_abnormal_eye_distance/2.01657909
17MP0009250_abnormal_appendicular_skeleto1.88320303
18MP0003705_abnormal_hypodermis_morpholog1.87718374
19MP0002089_abnormal_postnatal_growth/wei1.86101119
20MP0003690_abnormal_glial_cell1.83446728
21MP0001958_emphysema1.79447637
22MP0004858_abnormal_nervous_system1.76945962
23MP0002108_abnormal_muscle_morphology1.76389446
24MP0005623_abnormal_meninges_morphology1.75806172
25MP0000751_myopathy1.71087257
26MP0004145_abnormal_muscle_electrophysio1.68710485
27MP0005167_abnormal_blood-brain_barrier1.65875590
28MP0000537_abnormal_urethra_morphology1.65066056
29MP0002896_abnormal_bone_mineralization1.63304723
30MP0005508_abnormal_skeleton_morphology1.62704702
31MP0003279_aneurysm1.60485881
32MP0001879_abnormal_lymphatic_vessel1.53904767
33MP0005257_abnormal_intraocular_pressure1.53097399
34MP0002282_abnormal_trachea_morphology1.50455550
35MP0002909_abnormal_adrenal_gland1.47923181
36MP0009384_cardiac_valve_regurgitation1.46609942
37MP0002064_seizures1.46111134
38MP0009745_abnormal_behavioral_response1.44620915
39MP0000163_abnormal_cartilage_morphology1.44453337
40MP0004270_analgesia1.44144634
41MP0002063_abnormal_learning/memory/cond1.40725390
42MP0005423_abnormal_somatic_nervous1.36795537
43MP0003385_abnormal_body_wall1.35448435
44MP0002272_abnormal_nervous_system1.34393327
45MP0003938_abnormal_ear_development1.34181288
46MP0001440_abnormal_grooming_behavior1.33081101
47MP0000534_abnormal_ureter_morphology1.33078909
48MP0002115_abnormal_skeleton_extremities1.31772958
49MP0002184_abnormal_innervation1.30486212
50MP0002734_abnormal_mechanical_nocicepti1.26897448
51MP0001501_abnormal_sleep_pattern1.24132814
52MP0002067_abnormal_sensory_capabilities1.23763623
53MP0000013_abnormal_adipose_tissue1.22967837
54MP0003942_abnormal_urinary_system1.22243975
55MP0002572_abnormal_emotion/affect_behav1.19344797
56MP0003329_amyloid_beta_deposits1.18563149
57MP0002060_abnormal_skin_morphology1.12892744
58MP0002735_abnormal_chemical_nociception1.12318808
59MP0000681_abnormal_thyroid_gland1.12004797
60MP0001486_abnormal_startle_reflex1.11207675
61MP0009053_abnormal_anal_canal1.10418543
62MP0000462_abnormal_digestive_system1.10216460
63MP0010368_abnormal_lymphatic_system1.09714427
64MP0003091_abnormal_cell_migration1.09172226
65MP0000778_abnormal_nervous_system1.07768134
66MP0000955_abnormal_spinal_cord1.05298895
67MP0002249_abnormal_larynx_morphology1.04671362
68MP0002295_abnormal_pulmonary_circulatio1.01687853
69MP0002638_abnormal_pupillary_reflex1.00740625
70MP0001849_ear_inflammation1.00575764
71MP0005388_respiratory_system_phenotype1.00193791
72MP0002133_abnormal_respiratory_system1.00193791
73MP0001270_distended_abdomen0.99179053
74MP0001243_abnormal_dermal_layer0.98272024
75MP0003633_abnormal_nervous_system0.97035917
76MP0005595_abnormal_vascular_smooth0.96989116
77MP0005377_hearing/vestibular/ear_phenot0.94447466
78MP0003878_abnormal_ear_physiology0.94447466
79MP0001177_atelectasis0.94048187
80MP0003935_abnormal_craniofacial_develop0.93779893
81MP0005171_absent_coat_pigmentation0.91814838
82MP0003632_abnormal_nervous_system0.91712648
83MP0010030_abnormal_orbit_morphology0.91638547
84MP0000516_abnormal_urinary_system0.91558594
85MP0005367_renal/urinary_system_phenotyp0.91558594
86MP0001968_abnormal_touch/_nociception0.91415359
87MP0000428_abnormal_craniofacial_morphol0.91166018
88MP0000003_abnormal_adipose_tissue0.89457623
89MP0002736_abnormal_nociception_after0.89397869
90MP0000767_abnormal_smooth_muscle0.87539605
91MP0002116_abnormal_craniofacial_bone0.87528428
92MP0002733_abnormal_thermal_nociception0.87241041
93MP0000579_abnormal_nail_morphology0.87093242
94MP0001502_abnormal_circadian_rhythm0.86869436
95MP0002932_abnormal_joint_morphology0.86440405
96MP0004233_abnormal_muscle_weight0.85340587
97MP0002127_abnormal_cardiovascular_syste0.84867348
98MP0002113_abnormal_skeleton_development0.84364329
99MP0004484_altered_response_of0.83988825
100MP0002557_abnormal_social/conspecific_i0.83938026
101MP0002933_joint_inflammation0.83414987
102MP0002109_abnormal_limb_morphology0.83098829
103MP0003880_abnormal_central_pattern0.82361718
104MP0003045_fibrosis0.82303036
105MP0000049_abnormal_middle_ear0.81456817
106MP0003631_nervous_system_phenotype0.81044521
107MP0003115_abnormal_respiratory_system0.80684847
108MP0000639_abnormal_adrenal_gland0.80339513
109MP0002938_white_spotting0.78704537
110MP0001970_abnormal_pain_threshold0.78425008
111MP0002233_abnormal_nose_morphology0.77789640
112MP0005670_abnormal_white_adipose0.77481474
113MP0000762_abnormal_tongue_morphology0.77375986
114MP0006054_spinal_hemorrhage0.77231206
115MP0000432_abnormal_head_morphology0.77179605
116MP0002998_abnormal_bone_remodeling0.75987896
117MP0006138_congestive_heart_failure0.74626679
118MP0003122_maternal_imprinting0.74293745
119MP0000733_abnormal_muscle_development0.74220241
120MP0002128_abnormal_blood_circulation0.74192410
121MP0005409_darkened_coat_color0.73858637
122MP0002066_abnormal_motor_capabilities/c0.73575624
123MP0000747_muscle_weakness0.73535337
124MP0004811_abnormal_neuron_physiology0.71866027
125MP0000566_synostosis0.71666146
126MP0004130_abnormal_muscle_cell0.71482804
127MP0005390_skeleton_phenotype0.71118400
128MP0002697_abnormal_eye_size0.70416237
129MP0002152_abnormal_brain_morphology0.70246003
130MP0003634_abnormal_glial_cell0.68399413
131MP0001175_abnormal_lung_morphology0.68230696
132MP0003755_abnormal_palate_morphology0.68136583
133MP0002971_abnormal_brown_adipose0.67694043
134MP0001984_abnormal_olfaction0.67379379

Predicted human phenotypes

RankGene SetZ-score
1Broad metatarsal (HP:0001783)4.36002748
2Atrophic scars (HP:0001075)4.15327139
3Shallow orbits (HP:0000586)3.98039573
4Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.97034155
5Epiphyseal dysplasia (HP:0002656)3.95085700
6Protrusio acetabuli (HP:0003179)3.81831232
7Morphological abnormality of the middle ear (HP:0008609)3.75997019
8Action tremor (HP:0002345)3.60894870
9Neonatal short-limb short stature (HP:0008921)3.48438130
10Vitreoretinal degeneration (HP:0000655)3.46057223
11Hypoplastic ischia (HP:0003175)3.41350106
12Abnormality of dentin (HP:0010299)3.12546427
13Abnormality of the ischium (HP:0003174)3.04428423
14Hemiplegia (HP:0002301)3.03547718
15Bowel diverticulosis (HP:0005222)2.82464344
16Progressive cerebellar ataxia (HP:0002073)2.76042302
17Vertebral arch anomaly (HP:0008438)2.75202089
18Peritonitis (HP:0002586)2.74352232
19Aplasia involving bones of the upper limbs (HP:0009823)2.70982499
20Aplasia of the phalanges of the hand (HP:0009802)2.70982499
21Aplasia involving bones of the extremities (HP:0009825)2.70982499
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.70077905
23Short 4th metacarpal (HP:0010044)2.70077905
24Breech presentation (HP:0001623)2.69965788
25Calcaneovalgus deformity (HP:0001848)2.69696562
26Premature rupture of membranes (HP:0001788)2.68097572
27Deformed tarsal bones (HP:0008119)2.66561242
28Abnormal tarsal ossification (HP:0008369)2.66373894
29Osteoarthritis (HP:0002758)2.63621250
30Irregular epiphyses (HP:0010582)2.63427994
31Fragile skin (HP:0001030)2.63381248
32Ankle contracture (HP:0006466)2.62666398
33Aortic regurgitation (HP:0001659)2.61145554
34Obstructive sleep apnea (HP:0002870)2.55848391
35Abnormality of the middle phalanges of the toes (HP:0010183)2.54497493
36Mitral regurgitation (HP:0001653)2.53768325
37Dilatation of the ascending aorta (HP:0005111)2.52000578
38Abnormality of the 4th metacarpal (HP:0010012)2.49714121
39Aortic dissection (HP:0002647)2.47429799
40Cutaneous finger syndactyly (HP:0010554)2.46123012
41Broad ribs (HP:0000885)2.45151001
42Cupped ribs (HP:0000887)2.44141237
43Pulmonary artery stenosis (HP:0004415)2.41974980
44Nonimmune hydrops fetalis (HP:0001790)2.41958664
45Rectal prolapse (HP:0002035)2.41280216
46Overgrowth (HP:0001548)2.39409951
47Diplopia (HP:0000651)2.36523580
48Abnormality of binocular vision (HP:0011514)2.36523580
49Follicular hyperkeratosis (HP:0007502)2.34690974
50Humeroradial synostosis (HP:0003041)2.31915556
51Synostosis involving the elbow (HP:0003938)2.31915556
52Camptodactyly of toe (HP:0001836)2.31608276
53Aortic aneurysm (HP:0004942)2.30214577
54Joint laxity (HP:0001388)2.29858334
55Short hallux (HP:0010109)2.27271700
56Turricephaly (HP:0000262)2.24815116
57Slender build (HP:0001533)2.24499171
58Neurofibrillary tangles (HP:0002185)2.23116458
59Hemiparesis (HP:0001269)2.22134665
60Abnormality of the pubic bones (HP:0003172)2.19603766
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.18518783
62Blue sclerae (HP:0000592)2.18490617
63Cutaneous syndactyly (HP:0012725)2.17476693
64Bronchomalacia (HP:0002780)2.17387048
65Mild short stature (HP:0003502)2.14875753
66Coronal craniosynostosis (HP:0004440)2.12873646
67Flat capital femoral epiphysis (HP:0003370)2.12560555
68Mitral valve prolapse (HP:0001634)2.11963530
69Infantile muscular hypotonia (HP:0008947)2.11798663
70Spinal rigidity (HP:0003306)2.11379857
71Absent frontal sinuses (HP:0002688)2.09627964
72Bladder diverticulum (HP:0000015)2.08470429
73Narrow nasal bridge (HP:0000446)2.08393847
74Abnormality of skeletal muscle fiber size (HP:0012084)2.08206928
75Megalencephaly (HP:0001355)2.06904359
76Exostoses (HP:0100777)2.06502955
77Dysdiadochokinesis (HP:0002075)2.05362481
78Hypoplasia of the iris (HP:0007676)2.02227454
79Dysmetric saccades (HP:0000641)2.01684249
80Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.01632063
81Shawl scrotum (HP:0000049)2.01214800
82Vertebral compression fractures (HP:0002953)2.00812554
83Hyperextensible skin (HP:0000974)2.00382325
84Aplasia/Hypoplasia of the hallux (HP:0008362)2.00298202
85Ectopia lentis (HP:0001083)1.98878308
86Small epiphyses (HP:0010585)1.98350482
87Tracheomalacia (HP:0002779)1.97553997
88Limited hip movement (HP:0008800)1.97108605
89Broad long bones (HP:0005622)1.95634530
90Neoplasm of the heart (HP:0100544)1.94932995
91Chin dimple (HP:0010751)1.94767295
92Patent foramen ovale (HP:0001655)1.94212588
93Thoracolumbar scoliosis (HP:0002944)1.94092915
94Intention tremor (HP:0002080)1.93673922
95Cervical subluxation (HP:0003308)1.92954217
96Scanning speech (HP:0002168)1.91084368
97Abnormality of the parietal bone (HP:0002696)1.90991484
98Increased variability in muscle fiber diameter (HP:0003557)1.89678779
99Tetraplegia (HP:0002445)1.89190139
100Abnormality of the 2nd finger (HP:0004100)1.88295209
101Visual hallucinations (HP:0002367)1.88070930
102Wide anterior fontanel (HP:0000260)1.87662635
103Abnormal ossification of hand bones (HP:0005921)1.87154084
104Trigonocephaly (HP:0000243)1.87026568
105Mesomelia (HP:0003027)1.86867087
106Type 1 muscle fiber predominance (HP:0003803)1.86732666
107Abnormality of skull ossification (HP:0002703)1.85517235
108Hammertoe (HP:0001765)1.84957410
109Cerebral aneurysm (HP:0004944)1.84584782
110Facial shape deformation (HP:0011334)1.84384957
111Potter facies (HP:0002009)1.84384957
112Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.83928090
113Hepatoblastoma (HP:0002884)1.83400050
114Aortic valve stenosis (HP:0001650)1.82828999
115Abnormal delivery (HP:0001787)1.82764520
116Abnormality of the lower motor neuron (HP:0002366)1.81598143
117Mixed hearing impairment (HP:0000410)1.81282461
118Thin ribs (HP:0000883)1.80327541
119Midline defect of the nose (HP:0004122)1.80289329
120Decreased skull ossification (HP:0004331)1.79967887
121Abnormal hand bone ossification (HP:0010660)1.79686180
122Lumbar hyperlordosis (HP:0002938)1.79643827
123Biconcave vertebral bodies (HP:0004586)1.79575272
124Abnormality of the proximal phalanges of the hand (HP:0009834)1.79468436
125Hypoventilation (HP:0002791)1.79085569
126Abnormality of the middle phalanges of the hand (HP:0009833)1.78836983
127Deviation of the hallux (HP:0010051)1.78619988
128Wormian bones (HP:0002645)1.78396956
129Hip contracture (HP:0003273)1.78265049
130Cerebral inclusion bodies (HP:0100314)1.77569403
131Gaze-evoked nystagmus (HP:0000640)1.77141386
132Genetic anticipation (HP:0003743)1.77073073
133Delayed epiphyseal ossification (HP:0002663)1.76543519
134Focal motor seizures (HP:0011153)1.75762894
135Flat cornea (HP:0007720)1.75373161
136Ulnar bowing (HP:0003031)1.75072446
137Broad phalanx (HP:0006009)1.74941848
138Abnormality of the calcaneus (HP:0008364)1.73829728
139Abnormal foot bone ossification (HP:0010675)1.73553565
140Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.72760901
141Focal seizures (HP:0007359)1.72627486
142Genu recurvatum (HP:0002816)1.72583411
143Soft skin (HP:0000977)1.72524110
144Mildly elevated creatine phosphokinase (HP:0008180)1.72324969
145Genu varum (HP:0002970)1.71238621
146Flat acetabular roof (HP:0003180)1.70961677
147Striae distensae (HP:0001065)1.70933604
148Protruding ear (HP:0000411)1.70806001
149Arterial tortuosity (HP:0005116)1.70673967
150Aneurysm (HP:0002617)1.70506524
151Vascular tortuosity (HP:0004948)1.69555239
152Renovascular hypertension (HP:0100817)1.69282797
153Inguinal hernia (HP:0000023)1.69070119
154Long toe (HP:0010511)1.68076664
155Choanal stenosis (HP:0000452)1.67895907
156Spondylolisthesis (HP:0003302)1.64211728
157Joint contractures involving the joints of the feet (HP:0100492)1.63158816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR23.82604439
2RIPK13.61855283
3TRIB33.03194967
4SIK12.60392367
5CAMKK22.52326081
6MOS2.28579057
7PDGFRA2.23536394
8CASK2.16908801
9MARK11.93930881
10NTRK21.88717773
11NTRK31.87050528
12EPHB21.84050612
13PRKD31.80814255
14CAMKK11.80330964
15WNK11.76293700
16FGFR21.75376725
17PTK61.72706612
18PHKG21.71939525
19PHKG11.71939525
20CAMK1G1.70531871
21LATS11.66360970
22MINK11.57042161
23PAK61.53869892
24PRKCH1.48334714
25LMTK21.47947931
26STK381.47946254
27MAP3K41.45909483
28BCR1.38324128
29NTRK11.29200006
30CDK121.27937071
31UHMK11.26416455
32LATS21.24744347
33DAPK21.23769594
34MAP2K41.17591381
35CAMK1D1.17483949
36PKN21.15690473
37ERN11.15060041
38SGK31.14150628
39EPHA31.08987802
40MAPK121.07040160
41ROCK21.06901403
42PNCK1.06597753
43PRKCG1.03514630
44TYRO31.02151318
45SGK21.02071681
46ARAF1.02023377
47PTK21.01619481
48BRD41.00091455
49NEK90.96719893
50ROCK10.96272421
51FER0.96184869
52OXSR10.94102370
53SGK2230.94052574
54SGK4940.94052574
55FGFR10.93194552
56CDC42BPA0.92085014
57RET0.91504216
58CAMK2G0.91251603
59EPHB10.89489985
60MYLK0.88746017
61WNK40.87020959
62PAK30.81521130
63TIE10.81489088
64ERBB30.80643021
65PDGFRB0.80473419
66RPS6KA20.80364819
67YES10.79886343
68CAMK40.79225839
69TAOK10.77013127
70NEK20.77005575
71DYRK1A0.76900274
72BMX0.76758559
73CDK50.75612296
74DMPK0.75497616
75SIK20.72723626
76MAPK130.72436041
77TGFBR20.72259042
78RPS6KA40.71773149
79MAPK70.71529502
80CAMK2B0.70550280
81CAMK10.69754620
82MAP3K90.69554445
83MTOR0.69371382
84TTN0.68048537
85KSR10.67077565
86PLK20.66979108
87CLK10.66235419
88PRKG10.65367671
89MAP3K70.65278435
90MAP3K100.65004537
91MARK20.64059288
92PRKD10.63681958
93FGFR40.62885872
94CDK11A0.62210555
95PAK20.62110621
96EPHA40.61587268
97STK110.61564094
98TNIK0.61225722
99CDK180.61190692
100EEF2K0.59845513
101SGK10.59602229
102PTK2B0.58469376
103ALK0.58437162
104SRC0.57930956
105PINK10.56741000
106KIT0.56398319
107ADRBK10.54863597
108ERBB20.53790271
109KSR20.53161632
110DYRK20.53149730
111GRK10.52832935
112STK38L0.52748846
113MAPK100.52361256
114FYN0.52150493
115PIK3CA0.52010604
116JAK10.51911493
117DYRK1B0.51680881
118CSNK1G20.51399124
119PRKACG0.51087155
120CAMK2D0.50478978
121RPS6KL10.50358074
122RPS6KC10.50358074
123PRPF4B0.49720348
124FES0.49406801
125GSK3A0.49406800
126CAMK2A0.48835139
127GRK50.47666169
128ICK0.47488004
129AKT30.47420371
130PRKCE0.46736031
131CDK150.46290837
132TESK10.46289986
133PRKD20.45049021
134STK390.44558335
135CDK140.44527978
136CDK30.44381635
137MAPK40.44116732
138MAP3K60.41423586
139GRK60.40639064
140ABL20.39740452
141MAP3K130.39473662

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.20404180
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.00040722
3Nicotine addiction_Homo sapiens_hsa050332.42961631
4ECM-receptor interaction_Homo sapiens_hsa045122.13786037
5Glutamatergic synapse_Homo sapiens_hsa047242.04117165
6Protein digestion and absorption_Homo sapiens_hsa049741.93602944
7Circadian entrainment_Homo sapiens_hsa047131.85614453
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85239859
9Salivary secretion_Homo sapiens_hsa049701.84460765
10GABAergic synapse_Homo sapiens_hsa047271.82913569
11Long-term depression_Homo sapiens_hsa047301.69617793
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67596747
13Long-term potentiation_Homo sapiens_hsa047201.67224665
14Gastric acid secretion_Homo sapiens_hsa049711.65774867
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63152658
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62292860
17Bile secretion_Homo sapiens_hsa049761.59889215
18Adherens junction_Homo sapiens_hsa045201.51845231
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50245059
20Insulin secretion_Homo sapiens_hsa049111.40722494
21Morphine addiction_Homo sapiens_hsa050321.40150442
22Basal cell carcinoma_Homo sapiens_hsa052171.34789225
23Renal cell carcinoma_Homo sapiens_hsa052111.32727221
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32354280
25Renin secretion_Homo sapiens_hsa049241.32152227
26Thyroid hormone synthesis_Homo sapiens_hsa049181.31579334
27Hedgehog signaling pathway_Homo sapiens_hsa043401.28510549
28Prion diseases_Homo sapiens_hsa050201.28375525
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26543961
30Taste transduction_Homo sapiens_hsa047421.26271209
31Amphetamine addiction_Homo sapiens_hsa050311.25135746
32Focal adhesion_Homo sapiens_hsa045101.23676023
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23581316
34Synaptic vesicle cycle_Homo sapiens_hsa047211.19854950
35cAMP signaling pathway_Homo sapiens_hsa040241.17374880
36Notch signaling pathway_Homo sapiens_hsa043301.16573962
37Dilated cardiomyopathy_Homo sapiens_hsa054141.15353412
38Fatty acid biosynthesis_Homo sapiens_hsa000611.11935490
39Gap junction_Homo sapiens_hsa045401.10546926
40Estrogen signaling pathway_Homo sapiens_hsa049151.09904257
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.09604336
42Pancreatic secretion_Homo sapiens_hsa049721.08770108
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08373475
44Tight junction_Homo sapiens_hsa045301.07163446
45Type II diabetes mellitus_Homo sapiens_hsa049301.06456664
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05917741
47Cholinergic synapse_Homo sapiens_hsa047251.03666638
48Olfactory transduction_Homo sapiens_hsa047401.03201340
49Chronic myeloid leukemia_Homo sapiens_hsa052201.02777917
50Oxytocin signaling pathway_Homo sapiens_hsa049211.02469911
51Dopaminergic synapse_Homo sapiens_hsa047281.02430694
52MicroRNAs in cancer_Homo sapiens_hsa052061.00531427
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98220199
54Ras signaling pathway_Homo sapiens_hsa040140.97862127
55Calcium signaling pathway_Homo sapiens_hsa040200.97708398
56Melanogenesis_Homo sapiens_hsa049160.97627605
57Colorectal cancer_Homo sapiens_hsa052100.96334900
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95184987
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.94739823
60Proteoglycans in cancer_Homo sapiens_hsa052050.94437303
61Pathways in cancer_Homo sapiens_hsa052000.93584744
62Axon guidance_Homo sapiens_hsa043600.93223120
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89660205
64GnRH signaling pathway_Homo sapiens_hsa049120.88380976
65Cocaine addiction_Homo sapiens_hsa050300.86715494
66Amoebiasis_Homo sapiens_hsa051460.85364157
67Arginine biosynthesis_Homo sapiens_hsa002200.84060567
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82777466
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.81969124
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81325613
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80344397
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.78181734
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77921151
74Platelet activation_Homo sapiens_hsa046110.77232198
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76805300
76Insulin signaling pathway_Homo sapiens_hsa049100.76183272
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75981733
78Dorso-ventral axis formation_Homo sapiens_hsa043200.75322009
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74625694
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74361088
81Hippo signaling pathway_Homo sapiens_hsa043900.74315408
82PPAR signaling pathway_Homo sapiens_hsa033200.70562693
83VEGF signaling pathway_Homo sapiens_hsa043700.70045729
84Fatty acid metabolism_Homo sapiens_hsa012120.68746274
85AMPK signaling pathway_Homo sapiens_hsa041520.68275362
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67232020
87Wnt signaling pathway_Homo sapiens_hsa043100.66635476
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66569970
89Glioma_Homo sapiens_hsa052140.65800265
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65037460
91Butanoate metabolism_Homo sapiens_hsa006500.64734860
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63426294
93TGF-beta signaling pathway_Homo sapiens_hsa043500.63063477
94Prostate cancer_Homo sapiens_hsa052150.63020899
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62032354
96Pancreatic cancer_Homo sapiens_hsa052120.61974778
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.59717442
98Prolactin signaling pathway_Homo sapiens_hsa049170.57405537
99Rap1 signaling pathway_Homo sapiens_hsa040150.57232908
100Insulin resistance_Homo sapiens_hsa049310.56690768
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56372454
102Serotonergic synapse_Homo sapiens_hsa047260.55916965
103HIF-1 signaling pathway_Homo sapiens_hsa040660.54695563
104Mineral absorption_Homo sapiens_hsa049780.53577492
105Choline metabolism in cancer_Homo sapiens_hsa052310.53371100
106Ovarian steroidogenesis_Homo sapiens_hsa049130.53063330
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52950176
108Glucagon signaling pathway_Homo sapiens_hsa049220.52896418
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.52507942
110Complement and coagulation cascades_Homo sapiens_hsa046100.51239653
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49688303
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.49534996
113Circadian rhythm_Homo sapiens_hsa047100.49441895
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49423311
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.49292161
116FoxO signaling pathway_Homo sapiens_hsa040680.48646720
117MAPK signaling pathway_Homo sapiens_hsa040100.46165019
118Lysine degradation_Homo sapiens_hsa003100.45819010
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45649735
120Melanoma_Homo sapiens_hsa052180.44770161
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44094055
122Cardiac muscle contraction_Homo sapiens_hsa042600.43876679
123Endometrial cancer_Homo sapiens_hsa052130.42347322
124Fatty acid degradation_Homo sapiens_hsa000710.41745337
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41599831
126mTOR signaling pathway_Homo sapiens_hsa041500.40429830
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40263643
128ErbB signaling pathway_Homo sapiens_hsa040120.39708162

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