GDF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.16309769
2layer formation in cerebral cortex (GO:0021819)3.98125848
3pyrimidine nucleobase catabolic process (GO:0006208)3.86333377
4presynaptic membrane organization (GO:0097090)3.81536718
5cell proliferation in forebrain (GO:0021846)3.68010854
6innervation (GO:0060384)3.61407549
7cell migration in hindbrain (GO:0021535)3.57790860
8dosage compensation (GO:0007549)3.40765447
9neuron cell-cell adhesion (GO:0007158)3.39475686
10metanephric mesenchyme development (GO:0072075)3.38148322
11axon extension involved in axon guidance (GO:0048846)3.36362604
12neuron projection extension involved in neuron projection guidance (GO:1902284)3.36362604
13spinal cord development (GO:0021510)3.36131732
14ganglion development (GO:0061548)3.33939365
15kidney mesenchyme development (GO:0072074)3.26763232
16glomerulus development (GO:0032835)3.26438399
17generation of neurons (GO:0048699)3.25842493
18positive regulation of dendritic spine morphogenesis (GO:0061003)3.18604605
19outer ear morphogenesis (GO:0042473)3.14070683
20postsynaptic membrane organization (GO:0001941)3.13351735
21somite development (GO:0061053)3.12101017
22cell differentiation involved in metanephros development (GO:0072202)3.10780813
23sympathetic nervous system development (GO:0048485)3.04146274
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99166816
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97757347
26substrate-independent telencephalic tangential migration (GO:0021826)2.96861878
27substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.96861878
28negative chemotaxis (GO:0050919)2.95907396
29body morphogenesis (GO:0010171)2.90602861
30atrial cardiac muscle cell action potential (GO:0086014)2.87696109
31nucleobase catabolic process (GO:0046113)2.85025612
32mesenchyme morphogenesis (GO:0072132)2.81701381
33axonal fasciculation (GO:0007413)2.80000266
34regulation of synaptic vesicle exocytosis (GO:2000300)2.79660337
35embryonic body morphogenesis (GO:0010172)2.79586261
36neuron recognition (GO:0008038)2.78080242
37endocardial cushion morphogenesis (GO:0003203)2.77745172
38axon extension (GO:0048675)2.76756014
39regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76105416
40transmission of nerve impulse (GO:0019226)2.72806860
41dendritic spine morphogenesis (GO:0060997)2.72794164
42dermatan sulfate biosynthetic process (GO:0030208)2.71887845
43appendage development (GO:0048736)2.69142819
44limb development (GO:0060173)2.69142819
45kidney morphogenesis (GO:0060993)2.66341896
46proximal/distal pattern formation (GO:0009954)2.64765683
47positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.63009694
48olfactory bulb development (GO:0021772)2.62732099
49chondrocyte proliferation (GO:0035988)2.62708606
50regulation of short-term neuronal synaptic plasticity (GO:0048172)2.61909147
51peristalsis (GO:0030432)2.61372833
52head development (GO:0060322)2.60764736
53regulation of secondary heart field cardioblast proliferation (GO:0003266)2.59679177
54regulation of cardioblast proliferation (GO:0003264)2.59679177
55sensory perception of smell (GO:0007608)2.59346750
56nephron tubule morphogenesis (GO:0072078)2.58807755
57nephron epithelium morphogenesis (GO:0072088)2.58807755
58establishment of mitochondrion localization (GO:0051654)2.58465058
59protein localization to synapse (GO:0035418)2.57634953
60dendrite morphogenesis (GO:0048813)2.57504413
61central nervous system projection neuron axonogenesis (GO:0021952)2.57333990
62retinal ganglion cell axon guidance (GO:0031290)2.56897267
63negative regulation of axon extension involved in axon guidance (GO:0048843)2.56446772
64positive regulation of synapse assembly (GO:0051965)2.56255318
65planar cell polarity pathway involved in neural tube closure (GO:0090179)2.55500808
66retina layer formation (GO:0010842)2.55390507
67glial cell proliferation (GO:0014009)2.55355508
68single strand break repair (GO:0000012)2.53710501
69regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.53057282
70neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.52132387
71vocalization behavior (GO:0071625)2.51601536
72neurofilament cytoskeleton organization (GO:0060052)2.50986522
73axon ensheathment in central nervous system (GO:0032291)2.50059287
74central nervous system myelination (GO:0022010)2.50059287
75negative regulation of translation, ncRNA-mediated (GO:0040033)2.49991732
76regulation of translation, ncRNA-mediated (GO:0045974)2.49991732
77negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49991732
78positive regulation of mesonephros development (GO:0061213)2.49690378
79protein polyglutamylation (GO:0018095)2.49488689
80auditory behavior (GO:0031223)2.48179403
81synaptic vesicle maturation (GO:0016188)2.45637058
82dermatan sulfate metabolic process (GO:0030205)2.45393358
83forebrain neuron differentiation (GO:0021879)2.45155910
84synaptic transmission, glutamatergic (GO:0035249)2.44793875
85neuromuscular synaptic transmission (GO:0007274)2.44605874
86negative regulation of DNA repair (GO:0045738)2.44544853
87artery development (GO:0060840)2.43835894
88lung-associated mesenchyme development (GO:0060484)2.43826003
89thalamus development (GO:0021794)2.43474203
90negative regulation of oligodendrocyte differentiation (GO:0048715)2.43427103
91cell differentiation involved in kidney development (GO:0061005)2.41798390
92limb bud formation (GO:0060174)2.41551590
93positive regulation of synapse maturation (GO:0090129)2.40390794
94cardiovascular system development (GO:0072358)2.40062912
95regulation of synapse assembly (GO:0051963)2.40038472
96regulation of axon guidance (GO:1902667)2.39709635
97regulation of respiratory system process (GO:0044065)2.38467829
98locomotory exploration behavior (GO:0035641)2.37848970
99cerebral cortex radially oriented cell migration (GO:0021799)2.37546447
100nonmotile primary cilium assembly (GO:0035058)2.36352654
101negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.36188784
102negative regulation of fatty acid transport (GO:2000192)2.35980042
103negative regulation of catenin import into nucleus (GO:0035414)2.35575513
104regulation of gene silencing by RNA (GO:0060966)2.34253142
105regulation of posttranscriptional gene silencing (GO:0060147)2.34253142
106regulation of gene silencing by miRNA (GO:0060964)2.34253142
107positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.34145507
108regulation of Rac GTPase activity (GO:0032314)2.34062473
109presynaptic membrane assembly (GO:0097105)2.34009541
110regulation of synapse structural plasticity (GO:0051823)2.33774857
111establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.33310345
112mitochondrion transport along microtubule (GO:0047497)2.33310345
113negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.32919105
114hippocampus development (GO:0021766)2.32534702
115inner ear receptor stereocilium organization (GO:0060122)2.32360729
116regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.32116723
117neural crest cell development (GO:0014032)2.32083582
118regulation of respiratory gaseous exchange (GO:0043576)2.31181917
119dentate gyrus development (GO:0021542)2.30815014
120facial nerve structural organization (GO:0021612)2.29747787
121insulin-like growth factor receptor signaling pathway (GO:0048009)2.29476745
122forelimb morphogenesis (GO:0035136)2.29339351
123spinal cord association neuron differentiation (GO:0021527)2.29315526
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.29002505
125regulation of glutamate receptor signaling pathway (GO:1900449)2.28649119
126synapse assembly (GO:0007416)2.28361764
127negative regulation of transcription regulatory region DNA binding (GO:2000678)2.28044837
128lateral sprouting from an epithelium (GO:0060601)2.27853537
129regulation of synaptic vesicle transport (GO:1902803)2.27603642
130positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.27359304
131craniofacial suture morphogenesis (GO:0097094)2.26968720
132histone H3-K9 methylation (GO:0051567)2.24529521
133atrial septum morphogenesis (GO:0060413)2.24413985
134negative regulation of axon guidance (GO:1902668)2.24266479
135regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.24260480
136establishment of tissue polarity (GO:0007164)2.23898704
137establishment of planar polarity (GO:0001736)2.23898704
138regulation of axon extension involved in axon guidance (GO:0048841)2.23523415
139urinary tract smooth muscle contraction (GO:0014848)2.23470439
140response to auditory stimulus (GO:0010996)2.22536562
141cranial nerve structural organization (GO:0021604)2.22521455
142embryonic digit morphogenesis (GO:0042733)2.22414009
143neuron projection extension (GO:1990138)2.22184487
144cell differentiation in spinal cord (GO:0021515)2.22144401
145negative regulation of axon extension (GO:0030517)2.21319832
146regulation of cilium movement (GO:0003352)2.19611180
147relaxation of smooth muscle (GO:0044557)2.19586918
148hindbrain development (GO:0030902)2.18572674
149embryonic cranial skeleton morphogenesis (GO:0048701)2.18473858
150mechanosensory behavior (GO:0007638)2.18290201
151central nervous system neuron axonogenesis (GO:0021955)2.18065167
152regulation of non-canonical Wnt signaling pathway (GO:2000050)2.17846565
153regulation of mesonephros development (GO:0061217)2.17722160
154dendrite development (GO:0016358)2.17627357
155neuronal stem cell maintenance (GO:0097150)2.17626674
156neuron migration (GO:0001764)2.17505091
157embryonic forelimb morphogenesis (GO:0035115)2.16081954
158negative regulation of astrocyte differentiation (GO:0048712)2.15838987
159regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.15433583
160positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.15213206
161synaptic transmission, cholinergic (GO:0007271)2.14950162
162axonogenesis (GO:0007409)2.14882993
163neuronal ion channel clustering (GO:0045161)2.14096989
164negative regulation of Rho protein signal transduction (GO:0035024)2.13794321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.33832785
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.89796922
3GBX2_23144817_ChIP-Seq_PC3_Human3.03505850
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89523117
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87962051
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.87713411
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87667673
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87667673
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.81015362
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.72599582
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66574092
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60121705
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48697076
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48586301
15PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.47589148
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.47428436
17RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.26380879
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.17996943
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.13470043
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.10176265
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06651590
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04300320
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93505048
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91958018
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89942771
26RNF2_27304074_Chip-Seq_NSC_Mouse1.88692857
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86490986
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82935412
29ZNF274_21170338_ChIP-Seq_K562_Hela1.79674200
30AR_21572438_ChIP-Seq_LNCaP_Human1.78717514
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77515728
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75544913
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74731485
34RING1B_27294783_Chip-Seq_NPCs_Mouse1.74381314
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73124108
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.72346394
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69932550
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68629953
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.63563973
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.62674595
41* RING1B_27294783_Chip-Seq_ESCs_Mouse1.61582991
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.59100858
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.57106021
44VDR_22108803_ChIP-Seq_LS180_Human1.55028159
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54784588
46AHR_22903824_ChIP-Seq_MCF-7_Human1.49087984
47P300_19829295_ChIP-Seq_ESCs_Human1.48602259
48SMAD4_21799915_ChIP-Seq_A2780_Human1.45393091
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44756855
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.44675245
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44320479
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43395093
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42761004
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.41705993
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41574532
56* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.40858521
57DROSHA_22980978_ChIP-Seq_HELA_Human1.40434725
58TAF15_26573619_Chip-Seq_HEK293_Human1.39022053
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35097241
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33612097
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33550090
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32830947
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32272225
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32116872
65REST_21632747_ChIP-Seq_MESCs_Mouse1.30938897
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29786075
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.27352934
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.26822731
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26594235
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26399603
71* FUS_26573619_Chip-Seq_HEK293_Human1.24866679
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.24364492
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23688810
74* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23256055
75TP53_18474530_ChIP-ChIP_U2OS_Human1.23057935
76TP53_16413492_ChIP-PET_HCT116_Human1.22868012
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.22318170
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.20467878
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19746864
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19530614
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14864800
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.14580815
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14004462
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13467987
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12707649
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12073997
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11557763
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11262379
89AR_19668381_ChIP-Seq_PC3_Human1.09351105
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09284776
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08039512
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07433839
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07317230
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07233450
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06884332
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04752033
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03170063
98EWS_26573619_Chip-Seq_HEK293_Human1.02719370
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02580892
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.01116157
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00949359
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.00025561
103RARB_27405468_Chip-Seq_BRAIN_Mouse0.99990690
104STAT3_23295773_ChIP-Seq_U87_Human0.99944642
105IGF1R_20145208_ChIP-Seq_DFB_Human0.97892728
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97693739
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97693739
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96942860
109* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95524008
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95205938
111IRF1_19129219_ChIP-ChIP_H3396_Human0.94734823
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94530898
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94401718
114RUNX2_22187159_ChIP-Seq_PCA_Human0.94396063
115SOX9_26525672_Chip-Seq_HEART_Mouse0.94269754
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94173420
117REST_18959480_ChIP-ChIP_MESCs_Mouse0.94106598
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93385793
119HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92775309
120CTCF_27219007_Chip-Seq_Bcells_Human0.92591760
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92578990
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89204663
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88146617
124MYC_18940864_ChIP-ChIP_HL60_Human0.87717929
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87129904
126KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86608669
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85181936
128POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.83204941
129LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83058493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction3.29137158
2MP0003122_maternal_imprinting3.21511020
3MP0003787_abnormal_imprinting2.94946458
4* MP0008789_abnormal_olfactory_epithelium2.93692730
5* MP0005394_taste/olfaction_phenotype2.81788202
6* MP0005499_abnormal_olfactory_system2.81788202
7MP0010030_abnormal_orbit_morphology2.51819955
8MP0000049_abnormal_middle_ear2.44056636
9MP0003121_genomic_imprinting2.37322328
10* MP0009250_abnormal_appendicular_skeleto2.22863183
11MP0001188_hyperpigmentation2.14549204
12MP0003880_abnormal_central_pattern2.02234060
13MP0000778_abnormal_nervous_system1.97367910
14MP0006276_abnormal_autonomic_nervous1.93178003
15MP0002234_abnormal_pharynx_morphology1.90118391
16MP0004859_abnormal_synaptic_plasticity1.85919216
17MP0003136_yellow_coat_color1.81723296
18* MP0003942_abnormal_urinary_system1.80051312
19* MP0003385_abnormal_body_wall1.75829800
20MP0008877_abnormal_DNA_methylation1.75390159
21MP0003937_abnormal_limbs/digits/tail_de1.70900972
22MP0005503_abnormal_tendon_morphology1.70315250
23MP0002184_abnormal_innervation1.67149414
24MP0004133_heterotaxia1.67075631
25MP0003635_abnormal_synaptic_transmissio1.65631587
26MP0003283_abnormal_digestive_organ1.65150287
27MP0002751_abnormal_autonomic_nervous1.64792168
28MP0000566_synostosis1.61769888
29MP0005623_abnormal_meninges_morphology1.61765824
30* MP0002233_abnormal_nose_morphology1.61668637
31* MP0000534_abnormal_ureter_morphology1.60162265
32MP0003890_abnormal_embryonic-extraembry1.58869083
33MP0000631_abnormal_neuroendocrine_gland1.57192927
34MP0001293_anophthalmia1.56812102
35MP0009379_abnormal_foot_pigmentation1.53881410
36* MP0003755_abnormal_palate_morphology1.53169628
37MP0003938_abnormal_ear_development1.49795966
38MP0002249_abnormal_larynx_morphology1.49633232
39MP0009745_abnormal_behavioral_response1.45668221
40MP0002063_abnormal_learning/memory/cond1.40617616
41MP0008438_abnormal_cutaneous_collagen1.40509406
42MP0006292_abnormal_olfactory_placode1.38184955
43MP0005174_abnormal_tail_pigmentation1.37618752
44MP0000569_abnormal_digit_pigmentation1.36723783
45MP0001486_abnormal_startle_reflex1.35337192
46MP0002557_abnormal_social/conspecific_i1.30276911
47MP0004858_abnormal_nervous_system1.29139766
48* MP0002116_abnormal_craniofacial_bone1.28651793
49MP0002653_abnormal_ependyma_morphology1.28399578
50MP0005551_abnormal_eye_electrophysiolog1.25593443
51MP0002734_abnormal_mechanical_nocicepti1.24966777
52MP0005645_abnormal_hypothalamus_physiol1.24481044
53MP0004270_analgesia1.24138689
54MP0001177_atelectasis1.20574443
55* MP0003861_abnormal_nervous_system1.20401673
56MP0003935_abnormal_craniofacial_develop1.20026839
57MP0002638_abnormal_pupillary_reflex1.19624753
58MP0005248_abnormal_Harderian_gland1.19185879
59MP0000537_abnormal_urethra_morphology1.18648627
60MP0002932_abnormal_joint_morphology1.18231799
61MP0004233_abnormal_muscle_weight1.18052808
62* MP0002882_abnormal_neuron_morphology1.16278966
63MP0005171_absent_coat_pigmentation1.16079279
64MP0000428_abnormal_craniofacial_morphol1.14850728
65MP0001905_abnormal_dopamine_level1.14821534
66MP0000516_abnormal_urinary_system1.14139246
67MP0005367_renal/urinary_system_phenotyp1.14139246
68MP0003115_abnormal_respiratory_system1.14133223
69MP0002822_catalepsy1.13798038
70MP0001970_abnormal_pain_threshold1.13436903
71* MP0002752_abnormal_somatic_nervous1.11720308
72MP0005423_abnormal_somatic_nervous1.11459508
73MP0002177_abnormal_outer_ear1.10946968
74MP0002160_abnormal_reproductive_system1.10462576
75* MP0000955_abnormal_spinal_cord1.10294440
76MP0001299_abnormal_eye_distance/1.10045541
77MP0002102_abnormal_ear_morphology1.09932174
78MP0001502_abnormal_circadian_rhythm1.09343099
79MP0002697_abnormal_eye_size1.08555590
80MP0004134_abnormal_chest_morphology1.06530431
81MP0003279_aneurysm1.06176248
82MP0002152_abnormal_brain_morphology1.05858163
83MP0002733_abnormal_thermal_nociception1.05186173
84MP0001440_abnormal_grooming_behavior1.04952065
85MP0003123_paternal_imprinting1.04421464
86* MP0005195_abnormal_posterior_eye1.04097109
87MP0001986_abnormal_taste_sensitivity1.03200852
88MP0000762_abnormal_tongue_morphology1.03173786
89MP0004811_abnormal_neuron_physiology1.02545993
90MP0005646_abnormal_pituitary_gland1.02330407
91MP0002163_abnormal_gland_morphology1.02262154
92* MP0002081_perinatal_lethality1.00050152
93MP0006072_abnormal_retinal_apoptosis0.99889159
94MP0003646_muscle_fatigue0.98774743
95MP0000026_abnormal_inner_ear0.98571477
96MP0002572_abnormal_emotion/affect_behav0.97665641
97MP0004142_abnormal_muscle_tone0.97652597
98MP0004885_abnormal_endolymph0.97585740
99MP0004145_abnormal_muscle_electrophysio0.96784229
100MP0002064_seizures0.96314352
101MP0003315_abnormal_perineum_morphology0.94256472
102MP0001485_abnormal_pinna_reflex0.94179969
103MP0002272_abnormal_nervous_system0.93650118
104MP0000733_abnormal_muscle_development0.93457096
105MP0008569_lethality_at_weaning0.92424624
106MP0005257_abnormal_intraocular_pressure0.92099435
107MP0001968_abnormal_touch/_nociception0.91629535
108* MP0002114_abnormal_axial_skeleton0.90909731
109MP0000432_abnormal_head_morphology0.89693940
110MP0005508_abnormal_skeleton_morphology0.89591179
111MP0002067_abnormal_sensory_capabilities0.89142180
112MP0005386_behavior/neurological_phenoty0.88986450
113MP0004924_abnormal_behavior0.88986450
114MP0004130_abnormal_muscle_cell0.88854268
115MP0001919_abnormal_reproductive_system0.87521217
116MP0003567_abnormal_fetal_cardiomyocyte0.87249432
117MP0001529_abnormal_vocalization0.86686016
118* MP0002109_abnormal_limb_morphology0.86201356
119MP0002938_white_spotting0.85673666
120* MP0009053_abnormal_anal_canal0.84990647
121MP0001963_abnormal_hearing_physiology0.84382372
122MP0001286_abnormal_eye_development0.84300371
123MP0003119_abnormal_digestive_system0.84258465
124MP0009046_muscle_twitch0.84149342
125MP0002736_abnormal_nociception_after0.83600151
126MP0002735_abnormal_chemical_nociception0.79870736

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)3.10995505
2Ectopic kidney (HP:0000086)3.09687413
3Asymmetry of the thorax (HP:0001555)2.95978429
4Febrile seizures (HP:0002373)2.78112187
5Bifid tongue (HP:0010297)2.68464067
6Pancreatic fibrosis (HP:0100732)2.66321987
7High anterior hairline (HP:0009890)2.47329179
8Chronic hepatic failure (HP:0100626)2.41969529
9Abnormality of the phalanges of the hallux (HP:0010057)2.39954855
10Spinal cord lesions (HP:0100561)2.38424827
11Syringomyelia (HP:0003396)2.38424827
12Absent thumb (HP:0009777)2.38215731
13Cutaneous finger syndactyly (HP:0010554)2.33544862
14Nephronophthisis (HP:0000090)2.32257112
15Increased number of teeth (HP:0011069)2.32036878
16Morphological abnormality of the middle ear (HP:0008609)2.30791195
17Shallow orbits (HP:0000586)2.29810183
18Stenosis of the external auditory canal (HP:0000402)2.29055023
19Anophthalmia (HP:0000528)2.27228458
20Morphological abnormality of the inner ear (HP:0011390)2.26023649
21Pendular nystagmus (HP:0012043)2.25089610
22Narrow nasal bridge (HP:0000446)2.24225620
23Fibular aplasia (HP:0002990)2.23692019
24Mesomelia (HP:0003027)2.22544684
25Intestinal fistula (HP:0100819)2.20635127
26Patellar aplasia (HP:0006443)2.19206213
27Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.18558335
28Broad distal phalanx of finger (HP:0009836)2.18281550
29Aplasia/Hypoplasia of the patella (HP:0006498)2.16548036
30Pancreatic cysts (HP:0001737)2.14694219
31Genetic anticipation (HP:0003743)2.12878789
32Reticulocytopenia (HP:0001896)2.11955870
33Cutaneous syndactyly (HP:0012725)2.11837670
34Preaxial foot polydactyly (HP:0001841)2.11715305
35Colon cancer (HP:0003003)2.11657049
36Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.11547635
37Neoplasm of the adrenal cortex (HP:0100641)2.10311097
38Hypothermia (HP:0002045)2.08957785
39Abnormal number of incisors (HP:0011064)2.08188209
40Tarsal synostosis (HP:0008368)2.06613795
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05765288
42Short 4th metacarpal (HP:0010044)2.05765288
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05110736
44Myokymia (HP:0002411)2.03536184
45Synostosis involving bones of the feet (HP:0009140)2.02334807
46Synostosis involving bones of the lower limbs (HP:0009138)2.02334807
47Bradycardia (HP:0001662)2.01516360
48Preauricular pit (HP:0004467)2.00853960
49Periauricular skin pits (HP:0100277)2.00853960
50Renal dysplasia (HP:0000110)2.00326584
51Abnormality of the phalanges of the 5th finger (HP:0004213)1.98541223
52Aplasia involving bones of the upper limbs (HP:0009823)1.98145311
53Aplasia of the phalanges of the hand (HP:0009802)1.98145311
54Aplasia involving bones of the extremities (HP:0009825)1.98145311
55Hypoplasia of the ulna (HP:0003022)1.97340282
56Optic nerve coloboma (HP:0000588)1.96867629
57Anencephaly (HP:0002323)1.96248326
58Renal duplication (HP:0000075)1.96119570
59Optic nerve hypoplasia (HP:0000609)1.95786696
60Progressive cerebellar ataxia (HP:0002073)1.95122394
61Lip pit (HP:0100267)1.95027416
62Abnormality of the renal medulla (HP:0100957)1.94191340
63Pachygyria (HP:0001302)1.94011140
64Hepatoblastoma (HP:0002884)1.93837528
65Generalized hypotonia (HP:0001290)1.92991008
66Oligodactyly (hands) (HP:0001180)1.91531110
67Coronal craniosynostosis (HP:0004440)1.91110707
68Drooling (HP:0002307)1.89898241
69Abnormality of cochlea (HP:0000375)1.89028995
70Pelvic girdle muscle weakness (HP:0003749)1.89009053
71Maternal diabetes (HP:0009800)1.88888815
72Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.88778563
73Abnormality of dentin (HP:0010299)1.88202828
74Short middle phalanx of the 5th finger (HP:0004220)1.88050665
75Congenital stationary night blindness (HP:0007642)1.88027476
76Abnormality of the nasal septum (HP:0000419)1.87993598
77Abnormality of the phalanges of the 2nd finger (HP:0009541)1.87513482
78Focal motor seizures (HP:0011153)1.87265864
79Megalencephaly (HP:0001355)1.86662131
80Abnormality of the 1st metacarpal (HP:0010009)1.86519521
81Failure to thrive in infancy (HP:0001531)1.84638958
82Long nose (HP:0003189)1.84473689
83Deviation of the hallux (HP:0010051)1.83426346
84Myelomeningocele (HP:0002475)1.83284555
85Epileptic encephalopathy (HP:0200134)1.82979181
86Lissencephaly (HP:0001339)1.82713210
87Septo-optic dysplasia (HP:0100842)1.82673044
88Rectovaginal fistula (HP:0000143)1.81562732
89Rectal fistula (HP:0100590)1.81562732
90Abnormality of the labia minora (HP:0012880)1.79933834
91Sclerocornea (HP:0000647)1.79902249
92Abnormality of the middle phalanges of the toes (HP:0010183)1.79207583
93Abnormality of the aortic arch (HP:0012303)1.78733465
94Preaxial hand polydactyly (HP:0001177)1.78365567
95Abnormality of the intervertebral disk (HP:0005108)1.77059048
96Abnormal hair whorl (HP:0010721)1.76320615
97Abnormality of the musculature of the pelvis (HP:0001469)1.76093793
98Abnormality of the hip-girdle musculature (HP:0001445)1.76093793
99Lower limb amyotrophy (HP:0007210)1.75662847
100Small hand (HP:0200055)1.74764011
101Limb dystonia (HP:0002451)1.74527087
102Hypoplasia of the radius (HP:0002984)1.74302526
103Intellectual disability, moderate (HP:0002342)1.74222709
104Retinal dysplasia (HP:0007973)1.73647228
105Absent radius (HP:0003974)1.73247660
106Short thumb (HP:0009778)1.73136015
107Amblyopia (HP:0000646)1.72925325
108Papillary thyroid carcinoma (HP:0002895)1.72350918
109Abnormal pancreas size (HP:0012094)1.72253842
110Vitreoretinal degeneration (HP:0000655)1.71886339
111Hallux valgus (HP:0001822)1.71746286
112Abnormality of cells of the erythroid lineage (HP:0012130)1.71208162
113Aplasia/Hypoplasia of the hallux (HP:0008362)1.70075396
114Bony spicule pigmentary retinopathy (HP:0007737)1.69978006
115Deep philtrum (HP:0002002)1.69680134
116Turricephaly (HP:0000262)1.69655745
117Abnormality of midbrain morphology (HP:0002418)1.69499082
118Molar tooth sign on MRI (HP:0002419)1.69499082
119Aplasia involving forearm bones (HP:0009822)1.69045030
120Absent forearm bone (HP:0003953)1.69045030
121Short phalanx of the thumb (HP:0009660)1.68944223
122Oligodactyly (HP:0012165)1.68500419
123Primary atrial arrhythmia (HP:0001692)1.67955300
124Renal hypoplasia (HP:0000089)1.67834449
125Neonatal hypoglycemia (HP:0001998)1.67346305
126Tented upper lip vermilion (HP:0010804)1.67062072
127Atrial fibrillation (HP:0005110)1.65861460
128Synostosis of carpal bones (HP:0005048)1.65792251
129Abnormality of the 4th metacarpal (HP:0010012)1.63787065
130Hypoventilation (HP:0002791)1.63501803
131Duplication of thumb phalanx (HP:0009942)1.63409738
132Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63007945
133Short 1st metacarpal (HP:0010034)1.63007945
134Highly arched eyebrow (HP:0002553)1.62943988
135Type II lissencephaly (HP:0007260)1.62605164
136Volvulus (HP:0002580)1.61933551
137Abdominal situs inversus (HP:0003363)1.61649067
138Abnormality of abdominal situs (HP:0011620)1.61649067
139Excessive salivation (HP:0003781)1.61017672
140Bundle branch block (HP:0011710)1.60775831
141Thyroid carcinoma (HP:0002890)1.59823313
142Tubular atrophy (HP:0000092)1.59496412
143Narrow forehead (HP:0000341)1.59279890
144Gait imbalance (HP:0002141)1.58940009
145Forearm undergrowth (HP:0009821)1.58785725
146Aplasia/Hypoplasia of the ulna (HP:0006495)1.58776373
147Shawl scrotum (HP:0000049)1.58553131
148Cerebellar dysplasia (HP:0007033)1.58522109
149Labial hypoplasia (HP:0000066)1.58422493
150Atonic seizures (HP:0010819)1.58394314
151Bronchomalacia (HP:0002780)1.57847405
152Horseshoe kidney (HP:0000085)1.57794090
153Carpal synostosis (HP:0009702)1.57688498
154Symphalangism affecting the phalanges of the hand (HP:0009773)1.57613798
155Broad-based gait (HP:0002136)1.57490293
156Focal seizures (HP:0007359)1.57462964
157Triphalangeal thumb (HP:0001199)1.56538180
158Abnormality of incisor morphology (HP:0011063)1.55013481
159Abnormality of the proximal phalanges of the hand (HP:0009834)1.54229941
160Synostosis involving the elbow (HP:0003938)1.54211379
161Humeroradial synostosis (HP:0003041)1.54211379
162Broad toe (HP:0001837)1.54191019
163Broad finger (HP:0001500)1.54110904
164Supraventricular tachycardia (HP:0004755)1.53947316
165Short hallux (HP:0010109)1.53859747
166Vertebral arch anomaly (HP:0008438)1.53849841
167Papilledema (HP:0001085)1.53290751
168Aplasia/Hypoplasia of the fibula (HP:0006492)1.51473376
169Large eyes (HP:0001090)1.51094931
170Nuclear cataract (HP:0100018)1.50813375
171Broad long bones (HP:0005622)1.50693633
172Scrotal hypoplasia (HP:0000046)1.50475679
173True hermaphroditism (HP:0010459)1.49454059
174Chorioretinal atrophy (HP:0000533)1.49255894
175Supraventricular arrhythmia (HP:0005115)1.49102424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB33.80375057
2CASK3.66875268
3PRPF4B3.03558383
4MAP2K72.76632898
5MAPK132.74237513
6MKNK22.67382732
7MARK12.62991482
8MAP3K92.54792470
9MKNK12.37744664
10NTRK32.25778241
11STK162.21493407
12MAP3K42.16065688
13SGK22.08353755
14NTRK22.07154608
15TLK12.02782393
16CAMK1G2.01270788
17RIPK11.98688500
18WNK41.96347250
19MINK11.95136753
20TAF11.91612647
21PNCK1.91499603
22PLK21.89225139
23SGK2231.87251735
24SGK4941.87251735
25AKT31.86873032
26ZAK1.82802371
27EPHA41.70085522
28DDR21.68631373
29NME21.67829451
30TNIK1.63955402
31FGFR21.63018549
32BMPR21.60746479
33BMPR1B1.60601195
34WNK31.59131456
35CAMK1D1.52087401
36STK391.51917195
37FRK1.51412001
38TYRO31.46191795
39GRK11.46178605
40EPHB21.38915212
41DYRK1A1.38572922
42SGK31.35954307
43PAK31.32508868
44ACVR1B1.30898368
45MAP3K101.28589173
46LMTK21.26865249
47DYRK31.26274347
48FER1.23086758
49CDC71.17670102
50PINK11.16516450
51NEK21.16278210
52PLK31.12442025
53FGFR31.09073864
54LATS21.08249963
55CSNK1G21.01344679
56STK111.00033692
57CSNK1G30.97920845
58PHKG10.97366902
59PHKG20.97366902
60LIMK10.96555673
61PAK60.95859377
62TAOK20.94610682
63PRKCG0.92630384
64ROCK10.89828251
65ROCK20.89384583
66CAMK10.87930885
67ADRBK20.86826913
68CSNK1G10.84365757
69KSR10.84221071
70CHEK20.84026359
71UHMK10.83871795
72PDGFRA0.81798021
73CAMK2A0.80905852
74CDC42BPA0.80135217
75RPS6KB10.79115982
76YES10.79053592
77STK38L0.78197600
78NEK60.75224985
79CSNK1A1L0.74700613
80PIK3CA0.71762291
81CLK10.70788806
82DYRK20.69814912
83NUAK10.68637753
84RPS6KA20.67814534
85SIK30.67115720
86CAMKK10.66053344
87SRPK10.65833541
88BRAF0.65639954
89STK240.64745880
90FGFR10.63395434
91SIK20.63370283
92PRKCE0.62935411
93CSNK1E0.62829549
94MTOR0.60189528
95AURKA0.59940596
96CDK50.57760796
97SGK10.57392152
98CDK180.54976027
99ATR0.53223337
100NTRK10.52872475
101BRD40.52750318
102PRKDC0.52588135
103ADRBK10.51223409
104PKN20.50801284
105DYRK1B0.50249660
106NEK10.50183607
107TIE10.50059382
108CDK90.49702526
109DAPK20.48139403
110INSRR0.46859930
111TGFBR10.46737456
112CDK150.46262156
113RPS6KA60.46220000
114PLK10.45994946
115CDK140.45540198
116PRKD20.45336581
117PRKCH0.44668447
118MAPK140.43356396
119MAP2K40.43263699
120OBSCN0.43000415
121CHUK0.42837571
122CDK10.42512152
123CAMK40.42259944
124ATM0.41511717
125BRSK10.41305037
126TRPM70.40632410
127WNK10.40621617
128BCR0.39703820
129CCNB10.39501061
130CDK20.39060284
131EIF2AK20.38639364
132CSNK1D0.38328210
133CDK190.38173831
134MARK20.37597907
135GSK3B0.37464658
136CSNK1A10.36957106
137CDK11A0.36648520
138ALK0.36550850
139FGR0.36336621
140CDK30.36038649
141PRKD30.35103180
142PRKG10.34564845
143GRK70.34225452
144MUSK0.33645195
145CAMK2D0.33057355
146MAPK80.33048027
147MAPK100.32963459
148PRKCZ0.32845721
149SIK10.32271205
150MAPK90.31414520

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.73711954
2Nicotine addiction_Homo sapiens_hsa050332.48234238
3Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.14842109
4Synaptic vesicle cycle_Homo sapiens_hsa047212.03432221
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.00849834
6Axon guidance_Homo sapiens_hsa043601.92438195
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88510852
8GABAergic synapse_Homo sapiens_hsa047271.77187668
9Circadian entrainment_Homo sapiens_hsa047131.74902949
10Ribosome_Homo sapiens_hsa030101.63432185
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63043837
12Morphine addiction_Homo sapiens_hsa050321.62675669
13Cholinergic synapse_Homo sapiens_hsa047251.60108782
14Sulfur relay system_Homo sapiens_hsa041221.58842427
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57851576
16Fanconi anemia pathway_Homo sapiens_hsa034601.56710217
17Dilated cardiomyopathy_Homo sapiens_hsa054141.53393500
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52941661
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52658841
20Dopaminergic synapse_Homo sapiens_hsa047281.50938549
21Wnt signaling pathway_Homo sapiens_hsa043101.49455634
22Basal cell carcinoma_Homo sapiens_hsa052171.49123215
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.48217511
24Basal transcription factors_Homo sapiens_hsa030221.48024840
25Cocaine addiction_Homo sapiens_hsa050301.47942450
26Glutamatergic synapse_Homo sapiens_hsa047241.46547270
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43250839
28Hedgehog signaling pathway_Homo sapiens_hsa043401.42371923
29Lysine degradation_Homo sapiens_hsa003101.41627671
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40806838
31Serotonergic synapse_Homo sapiens_hsa047261.39606577
32Amphetamine addiction_Homo sapiens_hsa050311.38424054
33Insulin secretion_Homo sapiens_hsa049111.37234131
34Endometrial cancer_Homo sapiens_hsa052131.36513668
35Hippo signaling pathway_Homo sapiens_hsa043901.35777539
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33479239
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33408261
38Oxytocin signaling pathway_Homo sapiens_hsa049211.33209244
39Circadian rhythm_Homo sapiens_hsa047101.31709245
40Melanogenesis_Homo sapiens_hsa049161.31300447
41Gap junction_Homo sapiens_hsa045401.31287261
42RNA polymerase_Homo sapiens_hsa030201.29996641
43Long-term potentiation_Homo sapiens_hsa047201.27243201
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24145927
45Gastric acid secretion_Homo sapiens_hsa049711.23297942
46Colorectal cancer_Homo sapiens_hsa052101.22907818
47Melanoma_Homo sapiens_hsa052181.22469846
48Salivary secretion_Homo sapiens_hsa049701.22301661
49Long-term depression_Homo sapiens_hsa047301.17741463
50Taste transduction_Homo sapiens_hsa047421.17668906
51Parkinsons disease_Homo sapiens_hsa050121.16363208
52Glioma_Homo sapiens_hsa052141.16236628
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15780875
54TGF-beta signaling pathway_Homo sapiens_hsa043501.12267714
55Adherens junction_Homo sapiens_hsa045201.11257062
56Huntingtons disease_Homo sapiens_hsa050161.09272451
57Oxidative phosphorylation_Homo sapiens_hsa001901.09120106
58Homologous recombination_Homo sapiens_hsa034401.08690086
59Renin secretion_Homo sapiens_hsa049241.07375830
60Alzheimers disease_Homo sapiens_hsa050101.06450154
61GnRH signaling pathway_Homo sapiens_hsa049121.05641845
62MicroRNAs in cancer_Homo sapiens_hsa052061.05260704
63Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04231212
64ErbB signaling pathway_Homo sapiens_hsa040121.02823978
65cAMP signaling pathway_Homo sapiens_hsa040241.01772099
66mRNA surveillance pathway_Homo sapiens_hsa030151.01489580
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01303114
68Dorso-ventral axis formation_Homo sapiens_hsa043201.00912224
69Phototransduction_Homo sapiens_hsa047441.00514166
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97835310
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97297444
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96998578
73Steroid biosynthesis_Homo sapiens_hsa001000.96226378
74Non-small cell lung cancer_Homo sapiens_hsa052230.96058010
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95627875
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95008652
77Calcium signaling pathway_Homo sapiens_hsa040200.94167094
78FoxO signaling pathway_Homo sapiens_hsa040680.93643288
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.93147881
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92728251
81Prostate cancer_Homo sapiens_hsa052150.91575303
82Alcoholism_Homo sapiens_hsa050340.89583587
83Rap1 signaling pathway_Homo sapiens_hsa040150.89242373
84Focal adhesion_Homo sapiens_hsa045100.86630059
85RNA degradation_Homo sapiens_hsa030180.86155908
86Tight junction_Homo sapiens_hsa045300.86053767
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84419411
88Proteoglycans in cancer_Homo sapiens_hsa052050.83853606
89Cardiac muscle contraction_Homo sapiens_hsa042600.83314957
90Ras signaling pathway_Homo sapiens_hsa040140.82799356
91Estrogen signaling pathway_Homo sapiens_hsa049150.80896784
92Non-homologous end-joining_Homo sapiens_hsa034500.80726316
93Selenocompound metabolism_Homo sapiens_hsa004500.80367841
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78964906
95MAPK signaling pathway_Homo sapiens_hsa040100.78921314
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.77585622
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77153791
98Thyroid cancer_Homo sapiens_hsa052160.76478091
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75636654
100Pathways in cancer_Homo sapiens_hsa052000.75511690
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75344525
102Chronic myeloid leukemia_Homo sapiens_hsa052200.75173577
103Vibrio cholerae infection_Homo sapiens_hsa051100.74215347
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73977736
105Notch signaling pathway_Homo sapiens_hsa043300.72148912
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.71970032
107ECM-receptor interaction_Homo sapiens_hsa045120.71589983
108Oocyte meiosis_Homo sapiens_hsa041140.69583363
109Choline metabolism in cancer_Homo sapiens_hsa052310.69282958
110One carbon pool by folate_Homo sapiens_hsa006700.68034882
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66929594
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65118481
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64969636
114Cell cycle_Homo sapiens_hsa041100.63663549
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62991753
116mTOR signaling pathway_Homo sapiens_hsa041500.61719110
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.59353691
118Type II diabetes mellitus_Homo sapiens_hsa049300.58302520
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57928303
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57794742
121RNA transport_Homo sapiens_hsa030130.57217002
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56302671
123Collecting duct acid secretion_Homo sapiens_hsa049660.56189869
124Small cell lung cancer_Homo sapiens_hsa052220.55672816
125Prolactin signaling pathway_Homo sapiens_hsa049170.52906469
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52895301
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.52179915
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49016345
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48768879
130Renal cell carcinoma_Homo sapiens_hsa052110.48611185
131AMPK signaling pathway_Homo sapiens_hsa041520.47987549
132Spliceosome_Homo sapiens_hsa030400.41328565
133Thyroid hormone synthesis_Homo sapiens_hsa049180.39893425

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