GDF15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1platelet dense granule organization (GO:0060155)8.27606803
2thrombin receptor signaling pathway (GO:0070493)7.61116395
3positive regulation of p38MAPK cascade (GO:1900745)6.57720446
4Golgi transport vesicle coating (GO:0048200)5.63503987
5COPI coating of Golgi vesicle (GO:0048205)5.63503987
6activation of MAPKKK activity (GO:0000185)5.41222144
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.99211287
8protein retention in ER lumen (GO:0006621)4.68001673
9basement membrane organization (GO:0071711)4.60285545
10proline biosynthetic process (GO:0006561)4.59279512
11regulation of p38MAPK cascade (GO:1900744)4.39927460
12negative regulation of lipid storage (GO:0010888)4.37062045
13wound healing, spreading of epidermal cells (GO:0035313)4.22101238
14low-density lipoprotein particle clearance (GO:0034383)4.12276015
15positive regulation of lipid storage (GO:0010884)4.05646125
16secretory granule organization (GO:0033363)3.94082109
17very-low-density lipoprotein particle assembly (GO:0034379)3.91644494
18glucose 6-phosphate metabolic process (GO:0051156)3.91080415
19negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.90210126
20skin morphogenesis (GO:0043589)3.86800381
21negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.74644659
22activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.73180101
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.72230862
24response to muramyl dipeptide (GO:0032495)3.70497883
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67970773
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.67970773
27modulation by symbiont of host immune response (GO:0052553)3.67970773
28positive regulation by symbiont of host defense response (GO:0052509)3.67970773
29modulation by symbiont of host defense response (GO:0052031)3.67970773
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67970773
31neutrophil activation involved in immune response (GO:0002283)3.64815400
32intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.62265420
33positive regulation of chemokine biosynthetic process (GO:0045080)3.60670050
34positive regulation of nuclease activity (GO:0032075)3.58620630
35proline metabolic process (GO:0006560)3.56207301
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.52866849
37RNA destabilization (GO:0050779)3.52366633
38regulation of lipid storage (GO:0010883)3.51069699
39apoptotic cell clearance (GO:0043277)3.50657718
40positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.50226463
41endoplasmic reticulum unfolded protein response (GO:0030968)3.47536136
42mesodermal cell differentiation (GO:0048333)3.42672358
43protein localization to endosome (GO:0036010)3.38164517
44regulation of metalloenzyme activity (GO:0048552)3.36661260
45lung vasculature development (GO:0060426)3.35064002
46peptidyl-proline hydroxylation (GO:0019511)3.32374365
47endothelial cell chemotaxis (GO:0035767)3.32229489
48cell adhesion mediated by integrin (GO:0033627)3.30133435
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28586936
50cellular response to unfolded protein (GO:0034620)3.28396828
51L-serine transport (GO:0015825)3.28249466
52ER-nucleus signaling pathway (GO:0006984)3.27959907
53branching involved in mammary gland duct morphogenesis (GO:0060444)3.26566438
54intestinal cholesterol absorption (GO:0030299)3.22162816
55flavonoid metabolic process (GO:0009812)3.22081682
56NIK/NF-kappaB signaling (GO:0038061)3.21399884
57plasma lipoprotein particle assembly (GO:0034377)3.14806467
58protein hydroxylation (GO:0018126)3.14737370
59regulation of nuclease activity (GO:0032069)3.14322759
60regulation of response to osmotic stress (GO:0047484)3.14011487
61response to peptidoglycan (GO:0032494)3.11794134
62plasma lipoprotein particle clearance (GO:0034381)3.11762138
63ER overload response (GO:0006983)3.08845106
64regulation of plasminogen activation (GO:0010755)3.08399568
65positive regulation of heat generation (GO:0031652)3.08381761
66hyaluronan catabolic process (GO:0030214)3.08152107
67negative regulation of fibrinolysis (GO:0051918)3.08015377
68protoporphyrinogen IX metabolic process (GO:0046501)3.07827522
69regulation of translational fidelity (GO:0006450)3.06443871
70regulation of cholesterol storage (GO:0010885)3.04293483
71cellular response to topologically incorrect protein (GO:0035967)3.04020953
72macrophage activation involved in immune response (GO:0002281)3.03325374
73lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02911323
74desmosome organization (GO:0002934)3.02167250
75regulation of cholesterol biosynthetic process (GO:0045540)3.01338880
76positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.99980592
77GDP-mannose metabolic process (GO:0019673)2.99504599
78protein-lipid complex assembly (GO:0065005)2.99230995
79regulation of chemokine biosynthetic process (GO:0045073)2.99107646
80decidualization (GO:0046697)2.98853292
81regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.98437081
82macroautophagy (GO:0016236)2.96262736
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.95263400
84regulation of early endosome to late endosome transport (GO:2000641)2.93654463
85myeloid cell homeostasis (GO:0002262)2.92001955
86protein maturation by protein folding (GO:0022417)2.90954555
87regulation of mammary gland epithelial cell proliferation (GO:0033599)2.89672307
884-hydroxyproline metabolic process (GO:0019471)2.89247479
89serine transport (GO:0032329)2.88344681
90negative regulation of fatty acid biosynthetic process (GO:0045717)2.88174656
91L-phenylalanine metabolic process (GO:0006558)2.87970119
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.87970119
93response to endoplasmic reticulum stress (GO:0034976)2.86154334
94aldehyde catabolic process (GO:0046185)2.81822872
95carnitine metabolic process (GO:0009437)2.81525351
96peptidyl-glutamic acid carboxylation (GO:0017187)2.80369064
97protein carboxylation (GO:0018214)2.80369064
98positive regulation of extracellular matrix organization (GO:1903055)2.79609125
99response to laminar fluid shear stress (GO:0034616)2.78530425
100oligosaccharide catabolic process (GO:0009313)2.77306029
101positive regulation of cholesterol efflux (GO:0010875)2.76649284
102positive regulation of hormone metabolic process (GO:0032352)2.76552274
103hydrogen peroxide biosynthetic process (GO:0050665)2.76342194
104wound healing, spreading of cells (GO:0044319)2.74418948
105lung epithelium development (GO:0060428)2.74367689
106amino-acid betaine metabolic process (GO:0006577)2.73936770
107response to arsenic-containing substance (GO:0046685)2.73679738
108endothelial cell morphogenesis (GO:0001886)2.73313666
109positive regulation of blood coagulation (GO:0030194)2.73010862
110positive regulation of hemostasis (GO:1900048)2.73010862
111positive regulation of coagulation (GO:0050820)2.71679121
112regulation of fatty acid beta-oxidation (GO:0031998)2.70202665
113regulation of fever generation (GO:0031620)2.69433303
114positive regulation of sterol transport (GO:0032373)2.68551817
115positive regulation of cholesterol transport (GO:0032376)2.68551817
116cellular zinc ion homeostasis (GO:0006882)2.67299139
117embryo implantation (GO:0007566)2.65594863
118endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.65483040
119urea cycle (GO:0000050)2.65259945
120urea metabolic process (GO:0019627)2.65259945
121negative regulation of fatty acid transport (GO:2000192)2.65131576
122endocardial cushion development (GO:0003197)2.64960022
123response to gravity (GO:0009629)2.64248531
124cellular copper ion homeostasis (GO:0006878)2.63429767
125negative regulation of focal adhesion assembly (GO:0051895)2.63223905
126negative regulation of cell junction assembly (GO:1901889)2.63223905
127negative regulation of adherens junction organization (GO:1903392)2.63223905
128cell-substrate junction assembly (GO:0007044)2.62601881
129mammary gland epithelial cell proliferation (GO:0033598)2.62545980
130positive regulation of lipid catabolic process (GO:0050996)2.62069895
131establishment of apical/basal cell polarity (GO:0035089)2.60367014
132positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60122808
133endodermal cell differentiation (GO:0035987)2.59894771
134positive regulation of osteoblast proliferation (GO:0033690)2.59242105
135regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.58750924
136positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.58750924
137activation of NF-kappaB-inducing kinase activity (GO:0007250)2.58484730
138adherens junction assembly (GO:0034333)2.57445563
139regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.56866800
140negative regulation of cytokine production involved in immune response (GO:0002719)2.56464407
141melanin biosynthetic process (GO:0042438)2.56313338
142L-alpha-amino acid transmembrane transport (GO:1902475)2.56278281
143acute-phase response (GO:0006953)2.55437907
144cell-substrate adherens junction assembly (GO:0007045)2.55297064
145focal adhesion assembly (GO:0048041)2.55297064
146positive regulation of fatty acid beta-oxidation (GO:0032000)2.54733411
147activation of Rac GTPase activity (GO:0032863)2.54616481
148respiratory burst (GO:0045730)2.53982885
149hyaluronan metabolic process (GO:0030212)2.53278892
150regulation of podosome assembly (GO:0071801)2.53201673
151COPII vesicle coating (GO:0048208)2.53097183
152adhesion of symbiont to host (GO:0044406)2.52211246
153hemoglobin metabolic process (GO:0020027)2.52123825
154nucleotide-sugar biosynthetic process (GO:0009226)2.50655779
155cytoskeletal anchoring at plasma membrane (GO:0007016)2.50483099
156endoderm formation (GO:0001706)2.50425867
157regulation of apoptotic cell clearance (GO:2000425)2.49735826
158positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.49171507
159semaphorin-plexin signaling pathway (GO:0071526)2.48654803
160positive regulation of mRNA catabolic process (GO:0061014)2.48134219
161regulation of mRNA catabolic process (GO:0061013)2.47956036
162positive regulation of reactive oxygen species metabolic process (GO:2000379)2.47353929
1633-UTR-mediated mRNA stabilization (GO:0070935)2.46874722
164mitochondrial DNA metabolic process (GO:0032042)2.46068048
165regulation of integrin-mediated signaling pathway (GO:2001044)2.45431804
166T-helper 1 type immune response (GO:0042088)2.45302380
167regulation of heterotypic cell-cell adhesion (GO:0034114)2.44550131
168regulation of membrane protein ectodomain proteolysis (GO:0051043)2.44459796
169surfactant homeostasis (GO:0043129)2.44270082
170regulation of cholesterol esterification (GO:0010872)2.43333932
171adhesion of symbiont to host cell (GO:0044650)2.43083065
172virion attachment to host cell (GO:0019062)2.43083065
173nitrogen cycle metabolic process (GO:0071941)2.42872715
174regulation of NFAT protein import into nucleus (GO:0051532)2.42311652
175antigen processing and presentation via MHC class Ib (GO:0002475)2.41979953
176granulocyte activation (GO:0036230)2.41915356
177response to unfolded protein (GO:0006986)2.41837700
178positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.41696801
179regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.41696801
180positive regulation of macrophage differentiation (GO:0045651)2.41084698
181response to progesterone (GO:0032570)2.40725123
182regulation of mononuclear cell migration (GO:0071675)2.40671420
183chondrocyte proliferation (GO:0035988)2.40338073
184regulation of fibrinolysis (GO:0051917)2.40075266
185vesicle coating (GO:0006901)2.40027232
186regulation of cholesterol homeostasis (GO:2000188)2.39811093
187regulation of macrophage derived foam cell differentiation (GO:0010743)2.39099715
188positive regulation of astrocyte differentiation (GO:0048711)2.38077407
189cysteine metabolic process (GO:0006534)2.37198280
190glycolipid catabolic process (GO:0019377)2.37176489
191regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.36496799
192phagosome maturation (GO:0090382)2.36071867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human6.08770622
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.81154546
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.54251023
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.32916841
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.20876943
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.16617308
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.08396105
8* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.08131559
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.84877631
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.83191140
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.80521031
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.78785024
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.72377697
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69681408
15* LXR_22158963_ChIP-Seq_LIVER_Mouse2.65772755
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59551160
17* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.55547245
18* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54022484
19CLOCK_20551151_ChIP-Seq_293T_Human2.44302802
20* ESR1_21235772_ChIP-Seq_MCF-7_Human2.39577946
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32056126
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31029250
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.23114085
24SCL_19346495_ChIP-Seq_HPC-7_Human2.22921287
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12582690
26* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09481228
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05556205
28TRIM28_21343339_ChIP-Seq_HEK293_Human2.02443585
29* ESR2_21235772_ChIP-Seq_MCF-7_Human1.98821628
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96443708
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92582928
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83232646
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75879533
34RUNX_20019798_ChIP-Seq_JUKART_Human1.72325450
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71832469
36* TP53_22127205_ChIP-Seq_IMR90_Human1.69753446
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68195433
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.64689335
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64296068
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63713823
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63609727
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.62993130
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.59916829
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59338275
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58391392
46VDR_24763502_ChIP-Seq_THP-1_Human1.58136726
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57185555
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.52911892
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52751653
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52143048
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51675734
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50527609
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49395640
54* ELK3_25401928_ChIP-Seq_HUVEC_Human1.48264164
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46280507
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44158671
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42073585
58* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40973247
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39414679
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38909441
61* TCF7_22412390_ChIP-Seq_EML_Mouse1.38857629
62* ATF3_27146783_Chip-Seq_COLON_Human1.37844246
63* ZNF263_19887448_ChIP-Seq_K562_Human1.36894986
64* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35813468
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34990605
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34969583
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.34881688
68ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.34426715
69* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32295546
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31221246
71UBF1/2_26484160_Chip-Seq_HMECs_Human1.31083337
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28684920
73* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28376480
74* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28049089
75SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27183673
76* NCOR1_26117541_ChIP-Seq_K562_Human1.27013214
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.26608714
78* GATA6_25053715_ChIP-Seq_YYC3_Human1.25928537
79CREB1_26743006_Chip-Seq_LNCaP_Human1.25852758
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25824046
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25519602
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25519602
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24578623
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.24238122
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24142852
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23867038
87VDR_21846776_ChIP-Seq_THP-1_Human1.22066950
88SOX2_20726797_ChIP-Seq_SW620_Human1.22038076
89RUNX1_27514584_Chip-Seq_MCF-7_Human1.20603053
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20489029
91* FOXO3_23340844_ChIP-Seq_DLD1_Human1.19130304
92* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18704319
93* GATA1_19941826_ChIP-Seq_K562_Human1.18622710
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.17497127
95MAF_26560356_Chip-Seq_TH1_Human1.16859499
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16596649
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15462486
98LXR_22292898_ChIP-Seq_THP-1_Human1.14586589
99P68_20966046_ChIP-Seq_HELA_Human1.12017256
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11766829
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11749285
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11029046
103* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10888396
104VDR_24787735_ChIP-Seq_THP-1_Human1.10357436
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10199415
106* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08611861
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08384598
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08112542
109AR_21909140_ChIP-Seq_LNCAP_Human1.07617754
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07313036
111* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06630356
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06509301
113* RACK7_27058665_Chip-Seq_MCF-7_Human1.06446627
114TFEB_21752829_ChIP-Seq_HELA_Human1.05865148
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05382239
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04490905
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04065589
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04065589
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04065589
120UTX_26944678_Chip-Seq_JUKART_Human1.03934439
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03793550
122NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03793550
123* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03380798
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03333800
125ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03277860
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02717637
127* CHD1_26751641_Chip-Seq_LNCaP_Human1.02668842
128NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02649326
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01704591
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01634871
131RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01277874
132* KDM2B_26808549_Chip-Seq_DND41_Human1.00854926
133* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00765589
134STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00548650
135* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00447352
136SA1_27219007_Chip-Seq_ERYTHROID_Human1.00137370
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98263837
138SPI1_23127762_ChIP-Seq_K562_Human0.97271285
139MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94652630
140SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92727851
141SPI1_23547873_ChIP-Seq_NB4_Human0.91616495
142* GATA2_19941826_ChIP-Seq_K562_Human0.90676273
143KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90449985
144KDM2B_26808549_Chip-Seq_K562_Human0.89920245
145POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89089044
146* MYC_22102868_ChIP-Seq_BL_Human0.88663406
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88193076
148ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87194497

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.47219965
2MP0005451_abnormal_body_composition4.05203733
3MP0002139_abnormal_hepatobiliary_system3.64907080
4MP0004272_abnormal_basement_membrane3.60456088
5MP0003436_decreased_susceptibility_to3.56571991
6MP0009840_abnormal_foam_cell3.02945676
7MP0004510_myositis2.96810566
8MP0005257_abnormal_intraocular_pressure2.94267613
9MP0003303_peritoneal_inflammation2.92809058
10MP0005408_hypopigmentation2.77936902
11MP0001853_heart_inflammation2.67395435
12MP0005171_absent_coat_pigmentation2.59488381
13MP0004947_skin_inflammation2.49883586
14MP0004264_abnormal_extraembryonic_tissu2.49150133
15MP0005365_abnormal_bile_salt2.46881194
16MP0002419_abnormal_innate_immunity2.46856684
17MP0010352_gastrointestinal_tract_polyps2.42583377
18MP0003191_abnormal_cellular_cholesterol2.36316016
19MP0004858_abnormal_nervous_system2.34065451
20MP0002089_abnormal_postnatal_growth/wei2.30479266
21MP0005360_urolithiasis2.29130977
22MP0008260_abnormal_autophagy2.24722060
23MP0005000_abnormal_immune_tolerance2.21824498
24MP0002877_abnormal_melanocyte_morpholog2.21113723
25MP0005058_abnormal_lysosome_morphology2.13311290
26MP0001835_abnormal_antigen_presentation2.12683140
27MP0003448_altered_tumor_morphology2.05002828
28MP0009785_altered_susceptibility_to2.01481836
29MP0003705_abnormal_hypodermis_morpholog1.98590585
30MP0008875_abnormal_xenobiotic_pharmacok1.96123365
31MP0003453_abnormal_keratinocyte_physiol1.91924268
32MP0005464_abnormal_platelet_physiology1.87800152
33MP0003724_increased_susceptibility_to1.82072407
34MP0000569_abnormal_digit_pigmentation1.81935614
35MP0002452_abnormal_antigen_presenting1.81658301
36MP0003075_altered_response_to1.76861140
37MP0005025_abnormal_response_to1.76479297
38MP0003123_paternal_imprinting1.76363986
39MP0006082_CNS_inflammation1.75579431
40MP0005409_darkened_coat_color1.73740960
41MP0005076_abnormal_cell_differentiation1.71556011
42MP0001533_abnormal_skeleton_physiology1.71304809
43MP0005085_abnormal_gallbladder_physiolo1.68053902
44MP0002148_abnormal_hypersensitivity_rea1.67805260
45MP0010234_abnormal_vibrissa_follicle1.63932181
46MP0009764_decreased_sensitivity_to1.62430085
47MP0004233_abnormal_muscle_weight1.62021897
48MP0003566_abnormal_cell_adhesion1.61469863
49MP0002933_joint_inflammation1.55624050
50MP0002138_abnormal_hepatobiliary_system1.55574793
51MP0003172_abnormal_lysosome_physiology1.52592732
52MP0002723_abnormal_immune_serum1.51809376
53MP0009278_abnormal_bone_marrow1.51508154
54MP0002060_abnormal_skin_morphology1.50726695
55MP0010329_abnormal_lipoprotein_level1.48685787
56MP0001800_abnormal_humoral_immune1.46759652
57MP0002254_reproductive_system_inflammat1.45927061
58MP0001845_abnormal_inflammatory_respons1.45563359
59MP0000371_diluted_coat_color1.44030886
60MP0001915_intracranial_hemorrhage1.42558477
61MP0003941_abnormal_skin_development1.40464824
62MP0003183_abnormal_peptide_metabolism1.36504378
63MP0003195_calcinosis1.36107233
64MP0008469_abnormal_protein_level1.35660811
65MP0003186_abnormal_redox_activity1.34938061
66MP0001851_eye_inflammation1.34252199
67MP0000678_abnormal_parathyroid_gland1.34216807
68MP0005501_abnormal_skin_physiology1.34170533
69MP0001849_ear_inflammation1.33440879
70MP0003806_abnormal_nucleotide_metabolis1.32300761
71MP0001819_abnormal_immune_cell1.32073825
72MP0002420_abnormal_adaptive_immunity1.31383799
73MP0001790_abnormal_immune_system1.30169171
74MP0005387_immune_system_phenotype1.30169171
75MP0009780_abnormal_chondrocyte_physiolo1.29968610
76MP0000858_altered_metastatic_potential1.29854137
77MP0003252_abnormal_bile_duct1.29776930
78MP0005164_abnormal_response_to1.29151291
79MP0002405_respiratory_system_inflammati1.26373706
80MP0000566_synostosis1.26370338
81MP0005319_abnormal_enzyme/_coenzyme1.25422174
82MP0005023_abnormal_wound_healing1.25413053
83MP0000604_amyloidosis1.24224811
84MP0000609_abnormal_liver_physiology1.22515194
85MP0000343_altered_response_to1.22143554
86MP0005670_abnormal_white_adipose1.21370752
87MP0005166_decreased_susceptibility_to1.18629934
88MP0002998_abnormal_bone_remodeling1.17532084
89MP0010155_abnormal_intestine_physiology1.16115605
90MP0002166_altered_tumor_susceptibility1.15812019
91MP0003879_abnormal_hair_cell1.15758367
92MP0002006_tumorigenesis1.11979978
93MP0005397_hematopoietic_system_phenotyp1.11216668
94MP0001545_abnormal_hematopoietic_system1.11216668
95MP0000249_abnormal_blood_vessel1.09390690
96MP0005332_abnormal_amino_acid1.07743997
97MP0001666_abnormal_nutrient_absorption1.07667160
98MP0004883_abnormal_blood_vessel1.07238540
99MP0000627_abnormal_mammary_gland1.06775252
100MP0004381_abnormal_hair_follicle1.06753014
101MP0001501_abnormal_sleep_pattern1.05834325
102MP0000534_abnormal_ureter_morphology1.05066468
103MP0000003_abnormal_adipose_tissue1.04904212
104MP0000689_abnormal_spleen_morphology1.04209940
105MP0000685_abnormal_immune_system1.03628407
106MP0000372_irregular_coat_pigmentation1.03276149
107MP0001958_emphysema1.02660831
108MP0002075_abnormal_coat/hair_pigmentati1.02203548
109MP0003300_gastrointestinal_ulcer1.02071856
110MP0003828_pulmonary_edema1.01156961
111MP0003656_abnormal_erythrocyte_physiolo1.00068759
112MP0005167_abnormal_blood-brain_barrier0.99817777
113MP0003136_yellow_coat_color0.99719216
114MP0005083_abnormal_biliary_tract0.98468056
115MP0001186_pigmentation_phenotype0.98394500
116MP0009384_cardiac_valve_regurgitation0.96315250
117MP0002796_impaired_skin_barrier0.94524635
118MP0002136_abnormal_kidney_physiology0.92981447
119MP0009763_increased_sensitivity_to0.92719806
120MP0003315_abnormal_perineum_morphology0.92622353
121MP0002928_abnormal_bile_duct0.92436432
122MP0002118_abnormal_lipid_homeostasis0.92403174
123MP0005390_skeleton_phenotype0.90976176
124MP0005174_abnormal_tail_pigmentation0.89887703
125MP0001881_abnormal_mammary_gland0.89831028
126MP0001661_extended_life_span0.89679472
127MP0002722_abnormal_immune_system0.89378066
128MP0000747_muscle_weakness0.86282892
129MP0000015_abnormal_ear_pigmentation0.85432830
130MP0000716_abnormal_immune_system0.85374128
131MP0003942_abnormal_urinary_system0.84624221
132MP0002098_abnormal_vibrissa_morphology0.84030077
133MP0009643_abnormal_urine_homeostasis0.83247122
134MP0002896_abnormal_bone_mineralization0.83176166
135MP0000537_abnormal_urethra_morphology0.82624989
136MP0000598_abnormal_liver_morphology0.82604963
137MP0002295_abnormal_pulmonary_circulatio0.82242083
138MP0003091_abnormal_cell_migration0.82233405
139MP0009333_abnormal_splenocyte_physiolog0.81662102
140MP0010030_abnormal_orbit_morphology0.81149842
141MP0005621_abnormal_cell_physiology0.77241038
142MP0002086_abnormal_extraembryonic_tissu0.77115458
143MP0005197_abnormal_uvea_morphology0.76853860
144MP0009931_abnormal_skin_appearance0.74925473
145MP0004782_abnormal_surfactant_physiolog0.74783554
146MP0005084_abnormal_gallbladder_morpholo0.74390085
147MP0005584_abnormal_enzyme/coenzyme_acti0.73758491
148MP0003279_aneurysm0.73052302
149MP0002398_abnormal_bone_marrow0.72912169
150MP0010771_integument_phenotype0.72654930
151MP0005508_abnormal_skeleton_morphology0.71876619
152MP0003634_abnormal_glial_cell0.71341053
153MP0001216_abnormal_epidermal_layer0.71127101
154MP0005165_increased_susceptibility_to0.70471062
155MP0005384_cellular_phenotype0.68680994
156MP0006138_congestive_heart_failure0.68346968
157MP0000358_abnormal_cell_content/0.67377794
158MP0000767_abnormal_smooth_muscle0.67085571
159MP0008775_abnormal_heart_ventricle0.65602909
160MP0004019_abnormal_vitamin_homeostasis0.65084478
161MP0003329_amyloid_beta_deposits0.65020796
162MP0003122_maternal_imprinting0.64557703
163MP0005636_abnormal_mineral_homeostasis0.63583821
164MP0000733_abnormal_muscle_development0.62941069
165MP0003385_abnormal_body_wall0.62011700
166MP0001614_abnormal_blood_vessel0.61655541
167MP0005375_adipose_tissue_phenotype0.61652302
168MP0004808_abnormal_hematopoietic_stem0.60704015
169MP0003115_abnormal_respiratory_system0.60617739

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)4.85535457
2Recurrent abscess formation (HP:0002722)4.31213862
3Elevated erythrocyte sedimentation rate (HP:0003565)4.26545303
4Eczematoid dermatitis (HP:0000976)4.26185067
5Protrusio acetabuli (HP:0003179)4.20505747
6Axonal loss (HP:0003447)4.11976554
7Recurrent bacterial skin infections (HP:0005406)3.88852929
8Xanthomatosis (HP:0000991)3.78489681
9Abnormality of glutamine family amino acid metabolism (HP:0010902)3.77350510
10Premature rupture of membranes (HP:0001788)3.77023162
11Hydroxyprolinuria (HP:0003080)3.76177771
12Abnormality of proline metabolism (HP:0010907)3.76177771
13Increased cerebral lipofuscin (HP:0011813)3.74652779
14Abnormality of macrophages (HP:0004311)3.74540751
15Vacuolated lymphocytes (HP:0001922)3.70881180
16Cerebral aneurysm (HP:0004944)3.46676992
17Stomatitis (HP:0010280)3.41482933
18Mediastinal lymphadenopathy (HP:0100721)3.39474642
19Reticulocytosis (HP:0001923)3.38290232
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.37819287
21Amyloidosis (HP:0011034)3.37246198
22Distal upper limb amyotrophy (HP:0007149)3.35390516
23Upper limb amyotrophy (HP:0009129)3.35390516
24Interstitial pulmonary disease (HP:0006530)3.26686991
25Intrahepatic cholestasis (HP:0001406)3.26263673
26Hand muscle atrophy (HP:0009130)3.22680953
27Deep venous thrombosis (HP:0002625)3.21931198
28Achilles tendon contracture (HP:0001771)3.18371778
29Joint hemorrhage (HP:0005261)3.05643740
30J-shaped sella turcica (HP:0002680)3.03041251
31Hyperlipoproteinemia (HP:0010980)2.99501338
32Increased serum ferritin (HP:0003281)2.97387309
33Hypercholesterolemia (HP:0003124)2.96456977
34Cholecystitis (HP:0001082)2.95320399
35Abnormal gallbladder physiology (HP:0012438)2.95320399
36Tetraparesis (HP:0002273)2.93284833
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.93030985
38Systemic lupus erythematosus (HP:0002725)2.92011833
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.90986681
40Abnormality of glycolipid metabolism (HP:0010969)2.89566687
41Abnormality of liposaccharide metabolism (HP:0010968)2.89566687
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.89566687
43Bone cyst (HP:0012062)2.88171284
44Gingival bleeding (HP:0000225)2.83945737
45Myocardial infarction (HP:0001658)2.83153384
46Paraparesis (HP:0002385)2.79509023
47Flat acetabular roof (HP:0003180)2.78095650
48Abnormality of iron homeostasis (HP:0011031)2.75985082
49Hyperacusis (HP:0010780)2.75927807
50Gingivitis (HP:0000230)2.75819192
51Menorrhagia (HP:0000132)2.64423466
52Abnormality of the common coagulation pathway (HP:0010990)2.60241617
53Dysostosis multiplex (HP:0000943)2.58948475
54Elbow flexion contracture (HP:0002987)2.58589786
55Recurrent skin infections (HP:0001581)2.56488242
56Cervical subluxation (HP:0003308)2.55531023
57Pustule (HP:0200039)2.52516215
58Small epiphyses (HP:0010585)2.50773190
59Cardiovascular calcification (HP:0011915)2.50118688
60Growth hormone excess (HP:0000845)2.47916683
61Diaphragmatic weakness (HP:0009113)2.45137810
62Prolonged partial thromboplastin time (HP:0003645)2.43572825
63Complement deficiency (HP:0004431)2.42926753
64Abnormality of transition element cation homeostasis (HP:0011030)2.38556736
65Hyperglycinuria (HP:0003108)2.37109791
66Urticaria (HP:0001025)2.36108463
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34738091
68Broad face (HP:0000283)2.32348233
69Upper limb muscle weakness (HP:0003484)2.32276870
70Periodontitis (HP:0000704)2.31853171
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.31657073
72Myositis (HP:0100614)2.29802259
73Pancreatitis (HP:0001733)2.29421269
74Albinism (HP:0001022)2.26906053
75Urinary glycosaminoglycan excretion (HP:0003541)2.26569466
76Mucopolysacchariduria (HP:0008155)2.26569466
77Insomnia (HP:0100785)2.26433401
78Cholelithiasis (HP:0001081)2.21920501
79Skin nodule (HP:0200036)2.21232717
80Premature skin wrinkling (HP:0100678)2.20563358
81Abnormality of carpal bone ossification (HP:0006257)2.19169895
82Glomerulonephritis (HP:0000099)2.18380224
83Hemorrhage of the eye (HP:0011885)2.16125585
84Abnormality of complement system (HP:0005339)2.15524825
85Abnormality of the acetabulum (HP:0003170)2.15028265
86Distal lower limb muscle weakness (HP:0009053)2.13328981
87Esophageal varix (HP:0002040)2.13221776
88Spastic paraparesis (HP:0002313)2.12514613
89Hematochezia (HP:0002573)2.12009169
90Autoimmune thrombocytopenia (HP:0001973)2.11799486
91Nephritis (HP:0000123)2.11618456
92Epistaxis (HP:0000421)2.11243686
93Vertebral compression fractures (HP:0002953)2.10708328
94Polycythemia (HP:0001901)2.10597450
95Disinhibition (HP:0000734)2.08691879
96Ankle contracture (HP:0006466)2.07422564
97Trismus (HP:0000211)2.06868333
98Shallow orbits (HP:0000586)2.06850421
99Scanning speech (HP:0002168)2.06821057
100Abnormality of polysaccharide metabolism (HP:0011012)2.05930965
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05930965
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05930965
103Wormian bones (HP:0002645)2.05859805
104Petechiae (HP:0000967)2.03850695
105Asymmetry of the thorax (HP:0001555)2.01350820
106Neonatal death (HP:0003811)2.01168062
107Abnormal platelet function (HP:0011869)2.01112415
108Impaired platelet aggregation (HP:0003540)2.01112415
109Cellulitis (HP:0100658)2.00864113
110Disproportionate tall stature (HP:0001519)2.00615059
111Hyperammonemia (HP:0001987)2.00375849
112Blue sclerae (HP:0000592)2.00231978
113Progressive muscle weakness (HP:0003323)1.98584771
114Orchitis (HP:0100796)1.97359447
115Recurrent fungal infections (HP:0002841)1.97208249
116Abnormality of reticulocytes (HP:0004312)1.95288257
117Obstructive lung disease (HP:0006536)1.94013322
118Chronic obstructive pulmonary disease (HP:0006510)1.94013322
119Hyperglycinemia (HP:0002154)1.93817159
120Abnormality of the thoracic spine (HP:0100711)1.92984960
121Loss of speech (HP:0002371)1.92607581
122Pulmonary infiltrates (HP:0002113)1.92574017
123Biconcave vertebral bodies (HP:0004586)1.92210496
124Ulnar bowing (HP:0003031)1.92043111
125Abnormal gallbladder morphology (HP:0012437)1.91622908
126Entropion (HP:0000621)1.91513672
127Pathologic fracture (HP:0002756)1.91015717
128Cerebral inclusion bodies (HP:0100314)1.90831139
129Spondylolisthesis (HP:0003302)1.90731993
130Poikilocytosis (HP:0004447)1.90372022
131Thrombocytosis (HP:0001894)1.90215089
132Hypoalphalipoproteinemia (HP:0003233)1.89977313
133Abnormality of the intrinsic pathway (HP:0010989)1.89576351
134Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.89350898
135Abnormality of glycine metabolism (HP:0010895)1.88720890
136Abnormality of serine family amino acid metabolism (HP:0010894)1.88720890
137Mitral stenosis (HP:0001718)1.88101010
138Bone pain (HP:0002653)1.87876072
139Vascular tortuosity (HP:0004948)1.86943882
140Glomerulosclerosis (HP:0000096)1.86895580
141Coxa vara (HP:0002812)1.86230678
142Prolonged neonatal jaundice (HP:0006579)1.85950546
143Abnormal ossification of hand bones (HP:0005921)1.85734663
144Pterygium (HP:0001059)1.85218633
145Short nail (HP:0001799)1.84147439
146Spinal muscular atrophy (HP:0007269)1.83804007
147Abnormality of the gallbladder (HP:0005264)1.83494762
148Aneurysm (HP:0002617)1.81581631
149Vasculitis (HP:0002633)1.81383970
150Spinal rigidity (HP:0003306)1.81333270
151Fragile skin (HP:0001030)1.80349410
152Abnormality of the heme biosynthetic pathway (HP:0010472)1.79956857
153Bladder diverticulum (HP:0000015)1.79720725
154Abnormality of the Achilles tendon (HP:0005109)1.79581742
155Fat malabsorption (HP:0002630)1.78713795
156Nausea (HP:0002018)1.78660440
157Purpura (HP:0000979)1.77910990
158Abnormality of the distal phalanges of the toes (HP:0010182)1.77816329
159Mildly elevated creatine phosphokinase (HP:0008180)1.77759149
160Renal duplication (HP:0000075)1.77543813
161Nonimmune hydrops fetalis (HP:0001790)1.77479405
162Neurofibrillary tangles (HP:0002185)1.77017778
163Leukocytosis (HP:0001974)1.76663581
164Vascular calcification (HP:0004934)1.76404679
165Arterial tortuosity (HP:0005116)1.76189643
166Peripheral demyelination (HP:0011096)1.75926393
167Distal lower limb amyotrophy (HP:0008944)1.75828358
168Ileus (HP:0002595)1.74647964
169Back pain (HP:0003418)1.73823762
170Bronchomalacia (HP:0002780)1.73411063
171Abnormality of dentin (HP:0010299)1.72390195
172Long palpebral fissure (HP:0000637)1.72291065
173Stridor (HP:0010307)1.70496181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.02233684
2PIM24.80694328
3RIPK14.22920286
4MAP3K144.13540622
5ICK3.30199522
6TBK13.11353010
7MAP2K23.03103869
8ERN12.71904734
9LMTK22.59884797
10SMG12.54617954
11IKBKB2.50431302
12EEF2K2.43479590
13MAP4K12.40834226
14EIF2AK12.37341703
15DYRK32.23916337
16CDK122.22497837
17AKT32.13791789
18PDGFRA1.96422420
19NME21.88250773
20MAPKAPK31.85112901
21PRKD31.80302497
22MAP3K111.80092097
23CAMKK21.79619918
24TGFBR21.77927943
25MAP3K31.72222686
26MAPK71.68945262
27NTRK11.68806780
28IKBKE1.65652890
29MET1.64310355
30IRAK31.62141507
31CAMK1D1.58461732
32MAPK41.55703804
33ABL21.53061036
34STK101.40446012
35MAP2K31.36894933
36RIPK41.35689021
37RAF11.34446781
38ERBB41.32933602
39LATS21.26272773
40WNK41.24908703
41PDK21.24256045
42MAPK151.22382216
43MOS1.20010010
44PAK21.17015351
45DYRK1B1.16946970
46CHUK1.16728614
47PRKD21.16039579
48BLK1.15941438
49RPS6KA61.15498622
50TRIB31.15162127
51TTN1.12163788
52BMX1.12025497
53PBK1.10173223
54RPS6KC11.10105008
55RPS6KL11.10105008
56PIM11.10029670
57SCYL21.09472214
58TAOK21.06393437
59GSK3A1.05480644
60PRPF4B1.00854292
61HCK0.93288751
62MST1R0.90489695
63RPS6KA20.89560970
64TESK10.89417306
65RPS6KB20.89321970
66PDPK10.89278436
67IRAK40.87667049
68STK380.87456846
69DDR20.87241646
70EPHA20.84639175
71EIF2AK20.84289213
72DAPK30.83614735
73CDK70.78582675
74FGFR40.77291507
75MAP3K20.76535863
76DAPK20.76527590
77ABL10.75854818
78KIT0.75642739
79RPS6KA10.75369452
80NEK90.72487208
81TYK20.72038820
82TAOK10.71786837
83LATS10.70823298
84CAMKK10.70715673
85LRRK20.70063606
86PAK40.69396474
87CAMK1G0.65955064
88FLT30.65780860
89CSF1R0.64773382
90GRK70.63044943
91ERBB20.61242214
92SYK0.61173363
93SIK30.61015060
94EPHB10.60692408
95TIE10.60295936
96MAPKAPK20.59460752
97ZAP700.59064299
98CSK0.57678453
99MAP3K10.57140945
100KSR20.56818790
101TYRO30.53841477
102FGR0.53100291
103MARK20.52977864
104WNK10.52216147
105PDGFRB0.51843558
106PTK60.51709352
107CDC42BPA0.51668248
108PRKG20.51432445
109HIPK20.51245009
110CDK60.51174952
111JAK30.50547032
112JAK20.49650788
113PIK3CG0.49442757
114EGFR0.48495237
115LCK0.47752917
116AKT20.47267302
117LIMK10.46324873
118TXK0.46078923
119MAP3K80.45470983
120FGFR30.45384927
121ARAF0.45195708
122PKN20.44199187
123MAP3K120.43060446
124FER0.42203166
125MAP3K50.41838540
126JAK10.40687731
127CSNK1A1L0.39172425
128MYLK0.37496546
129MAPK110.37153553
130SIK10.36774601
131STK390.36268661
132BRAF0.36151719
133RPS6KA40.33524761
134FGFR10.33506399
135TESK20.33425666
136BTK0.33312619
137INSR0.33026363
138MAP2K10.32935329
139MTOR0.32788871
140MAPK30.32603336
141BRSK10.32297088
142LYN0.30777685
143CDK90.28668014
144PRKAA20.28588716
145ILK0.27968092
146PTK20.27641608
147CDK80.27509409
148PRKCI0.26246741
149PRKAA10.26135678
150EPHB20.26113343

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.72026142
2Leishmaniasis_Homo sapiens_hsa051403.25253373
3Complement and coagulation cascades_Homo sapiens_hsa046103.13119531
4Staphylococcus aureus infection_Homo sapiens_hsa051502.73316977
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48479491
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.41898777
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.34651640
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.34058470
9Arginine biosynthesis_Homo sapiens_hsa002202.24673716
10Fructose and mannose metabolism_Homo sapiens_hsa000512.23597655
11Rheumatoid arthritis_Homo sapiens_hsa053232.11455769
12Osteoclast differentiation_Homo sapiens_hsa043802.09462788
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03327059
14N-Glycan biosynthesis_Homo sapiens_hsa005101.93976267
15TNF signaling pathway_Homo sapiens_hsa046681.86489952
16Pertussis_Homo sapiens_hsa051331.81741711
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80030140
18Vitamin B6 metabolism_Homo sapiens_hsa007501.78021305
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76848085
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75740139
21Legionellosis_Homo sapiens_hsa051341.73834457
22Malaria_Homo sapiens_hsa051441.69647041
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.63312082
24ECM-receptor interaction_Homo sapiens_hsa045121.61333384
25Lysosome_Homo sapiens_hsa041421.58298823
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.57214144
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56720053
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46324721
29Apoptosis_Homo sapiens_hsa042101.43837977
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40803995
31Thyroid cancer_Homo sapiens_hsa052161.40283234
32Phagosome_Homo sapiens_hsa041451.34688916
33B cell receptor signaling pathway_Homo sapiens_hsa046621.34601645
34Pentose phosphate pathway_Homo sapiens_hsa000301.32778316
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30497626
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29929073
37Tuberculosis_Homo sapiens_hsa051521.28788502
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27675786
39Salmonella infection_Homo sapiens_hsa051321.23405292
40Collecting duct acid secretion_Homo sapiens_hsa049661.22819409
41Histidine metabolism_Homo sapiens_hsa003401.17832444
42Sphingolipid metabolism_Homo sapiens_hsa006001.17388572
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15386593
44Fatty acid biosynthesis_Homo sapiens_hsa000611.14018037
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13378078
46Chemical carcinogenesis_Homo sapiens_hsa052041.11531934
47Bladder cancer_Homo sapiens_hsa052191.11249763
48Vitamin digestion and absorption_Homo sapiens_hsa049771.09981824
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09567143
50Shigellosis_Homo sapiens_hsa051311.09035006
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05984563
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04640604
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04162696
54Fatty acid degradation_Homo sapiens_hsa000711.03657190
55PPAR signaling pathway_Homo sapiens_hsa033201.03592705
56Selenocompound metabolism_Homo sapiens_hsa004501.01405483
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00971315
58Focal adhesion_Homo sapiens_hsa045100.99016670
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98818878
60African trypanosomiasis_Homo sapiens_hsa051430.98594957
61Prostate cancer_Homo sapiens_hsa052150.95278235
62Graft-versus-host disease_Homo sapiens_hsa053320.94627278
63HIF-1 signaling pathway_Homo sapiens_hsa040660.94377055
64mTOR signaling pathway_Homo sapiens_hsa041500.92677221
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.91446343
66Non-small cell lung cancer_Homo sapiens_hsa052230.91051557
67Protein digestion and absorption_Homo sapiens_hsa049740.90884807
68Bile secretion_Homo sapiens_hsa049760.90765332
69Tyrosine metabolism_Homo sapiens_hsa003500.90347801
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89944570
71Carbon metabolism_Homo sapiens_hsa012000.88974065
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88420141
73Fat digestion and absorption_Homo sapiens_hsa049750.88238474
74Starch and sucrose metabolism_Homo sapiens_hsa005000.88143446
75Notch signaling pathway_Homo sapiens_hsa043300.88116323
76VEGF signaling pathway_Homo sapiens_hsa043700.87251587
77Endometrial cancer_Homo sapiens_hsa052130.85682340
78ABC transporters_Homo sapiens_hsa020100.84633927
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84204515
80Insulin signaling pathway_Homo sapiens_hsa049100.83691703
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83326170
82Prion diseases_Homo sapiens_hsa050200.79957643
83Platelet activation_Homo sapiens_hsa046110.79283200
84Chronic myeloid leukemia_Homo sapiens_hsa052200.79147462
85AMPK signaling pathway_Homo sapiens_hsa041520.78386753
86MicroRNAs in cancer_Homo sapiens_hsa052060.77577612
87Toxoplasmosis_Homo sapiens_hsa051450.75632869
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.75289449
89Amoebiasis_Homo sapiens_hsa051460.74362982
90Tryptophan metabolism_Homo sapiens_hsa003800.73637094
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73310346
92Influenza A_Homo sapiens_hsa051640.71379892
93Glioma_Homo sapiens_hsa052140.71368998
94Pancreatic cancer_Homo sapiens_hsa052120.71222986
95Thyroid hormone synthesis_Homo sapiens_hsa049180.70901443
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70187152
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.70107165
98Hematopoietic cell lineage_Homo sapiens_hsa046400.69623809
99Caffeine metabolism_Homo sapiens_hsa002320.69489672
100Hepatitis B_Homo sapiens_hsa051610.69285665
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68774268
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68670405
103Renal cell carcinoma_Homo sapiens_hsa052110.68623012
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68111672
105ErbB signaling pathway_Homo sapiens_hsa040120.67844907
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67572779
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65477816
108Insulin resistance_Homo sapiens_hsa049310.63261125
109Lysine degradation_Homo sapiens_hsa003100.61746384
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60527814
111Peroxisome_Homo sapiens_hsa041460.60194626
112Adherens junction_Homo sapiens_hsa045200.58663663
113Steroid biosynthesis_Homo sapiens_hsa001000.57866553
114beta-Alanine metabolism_Homo sapiens_hsa004100.57747661
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57713240
116Hepatitis C_Homo sapiens_hsa051600.57454036
117Galactose metabolism_Homo sapiens_hsa000520.56947112
118Vibrio cholerae infection_Homo sapiens_hsa051100.56234519
119Measles_Homo sapiens_hsa051620.56050877
120Glutathione metabolism_Homo sapiens_hsa004800.55181465
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55024186
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54140350
123Sulfur relay system_Homo sapiens_hsa041220.52428958
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52374588
125Small cell lung cancer_Homo sapiens_hsa052220.51155639
126Melanoma_Homo sapiens_hsa052180.50997917
127Tight junction_Homo sapiens_hsa045300.49948995
128Phenylalanine metabolism_Homo sapiens_hsa003600.47689428
129Inositol phosphate metabolism_Homo sapiens_hsa005620.47346787
130Propanoate metabolism_Homo sapiens_hsa006400.46250344
131Acute myeloid leukemia_Homo sapiens_hsa052210.45670625
132Proteoglycans in cancer_Homo sapiens_hsa052050.44616656
133Hippo signaling pathway_Homo sapiens_hsa043900.44393558
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.44352870
135Colorectal cancer_Homo sapiens_hsa052100.43670792
136Endocytosis_Homo sapiens_hsa041440.41826437
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41500228
138Asthma_Homo sapiens_hsa053100.41458395
139One carbon pool by folate_Homo sapiens_hsa006700.41045345
140Fatty acid metabolism_Homo sapiens_hsa012120.40882305
141Other glycan degradation_Homo sapiens_hsa005110.40686048
142T cell receptor signaling pathway_Homo sapiens_hsa046600.40230209
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.39685795
144Arginine and proline metabolism_Homo sapiens_hsa003300.38618850
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38499814
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37626636
1472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36792493
148Biosynthesis of amino acids_Homo sapiens_hsa012300.36506787
149FoxO signaling pathway_Homo sapiens_hsa040680.36444616
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.36280085
151Antigen processing and presentation_Homo sapiens_hsa046120.34902192
152Prolactin signaling pathway_Homo sapiens_hsa049170.34579696
153Mineral absorption_Homo sapiens_hsa049780.33478530
154Maturity onset diabetes of the young_Homo sapiens_hsa049500.33400471
155Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33060177
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30565218
157p53 signaling pathway_Homo sapiens_hsa041150.30223112

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