GDF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)9.93804535
2exogenous drug catabolic process (GO:0042738)9.84250588
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.61442961
4L-phenylalanine catabolic process (GO:0006559)7.61442961
5regulation of plasminogen activation (GO:0010755)7.44759455
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27281988
7L-phenylalanine metabolic process (GO:0006558)7.27281988
8aromatic amino acid family catabolic process (GO:0009074)6.80540631
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.45824713
10drug metabolic process (GO:0017144)6.16332393
11tryptophan catabolic process (GO:0006569)6.09251237
12indole-containing compound catabolic process (GO:0042436)6.09251237
13indolalkylamine catabolic process (GO:0046218)6.09251237
14ethanol metabolic process (GO:0006067)6.00367634
15kynurenine metabolic process (GO:0070189)5.98706038
16bile acid biosynthetic process (GO:0006699)5.88932933
17negative regulation of fibrinolysis (GO:0051918)5.84098599
18glyoxylate metabolic process (GO:0046487)5.82853868
19oxidative demethylation (GO:0070989)5.74694040
20tryptophan metabolic process (GO:0006568)5.74223022
21high-density lipoprotein particle remodeling (GO:0034375)5.73369462
22urea cycle (GO:0000050)5.67388725
23urea metabolic process (GO:0019627)5.67388725
24regulation of fibrinolysis (GO:0051917)5.62398266
25opsonization (GO:0008228)5.61722536
26alpha-linolenic acid metabolic process (GO:0036109)5.58953144
27complement activation, alternative pathway (GO:0006957)5.44649168
28protein carboxylation (GO:0018214)5.44627081
29peptidyl-glutamic acid carboxylation (GO:0017187)5.44627081
30regulation of protein activation cascade (GO:2000257)5.42512729
31sulfur amino acid catabolic process (GO:0000098)5.31022707
32cysteine metabolic process (GO:0006534)5.29064754
33nitrogen cycle metabolic process (GO:0071941)5.20887979
34S-adenosylmethionine metabolic process (GO:0046500)5.15725424
35serine family amino acid catabolic process (GO:0009071)5.11747516
36reverse cholesterol transport (GO:0043691)5.05179335
37bile acid metabolic process (GO:0008206)5.04535775
38regulation of complement activation (GO:0030449)5.04429094
39regulation of cholesterol esterification (GO:0010872)4.99653650
40aromatic amino acid family metabolic process (GO:0009072)4.93686458
41regulation of triglyceride catabolic process (GO:0010896)4.91839525
42plasma lipoprotein particle remodeling (GO:0034369)4.91563621
43protein-lipid complex remodeling (GO:0034368)4.91563621
44macromolecular complex remodeling (GO:0034367)4.91563621
45tyrosine metabolic process (GO:0006570)4.86231146
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80346616
47disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.75528449
48killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.75528449
49homocysteine metabolic process (GO:0050667)4.73591422
50regulation of humoral immune response (GO:0002920)4.69423105
51phospholipid efflux (GO:0033700)4.68102387
52acylglycerol homeostasis (GO:0055090)4.67303465
53triglyceride homeostasis (GO:0070328)4.67303465
54alpha-amino acid catabolic process (GO:1901606)4.62955748
55amino-acid betaine metabolic process (GO:0006577)4.59596974
56negative regulation of sterol transport (GO:0032372)4.56491206
57negative regulation of cholesterol transport (GO:0032375)4.56491206
58lysine catabolic process (GO:0006554)4.56381080
59lysine metabolic process (GO:0006553)4.56381080
60cellular ketone body metabolic process (GO:0046950)4.55976534
61phenylpropanoid metabolic process (GO:0009698)4.50300348
62plasma lipoprotein particle clearance (GO:0034381)4.49564837
63glycine metabolic process (GO:0006544)4.43541296
64bile acid and bile salt transport (GO:0015721)4.35057462
65cholesterol efflux (GO:0033344)4.34526112
66indolalkylamine metabolic process (GO:0006586)4.31233437
67imidazole-containing compound metabolic process (GO:0052803)4.30256754
68coenzyme catabolic process (GO:0009109)4.28078699
69negative regulation of blood coagulation (GO:0030195)4.28024097
70negative regulation of hemostasis (GO:1900047)4.28024097
71cellular amino acid catabolic process (GO:0009063)4.24534214
72glutamate metabolic process (GO:0006536)4.23119638
73amine catabolic process (GO:0009310)4.21800018
74cellular biogenic amine catabolic process (GO:0042402)4.21800018
75serine family amino acid metabolic process (GO:0009069)4.15039508
76plasma lipoprotein particle assembly (GO:0034377)4.14947894
77positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.14427017
78fibrinolysis (GO:0042730)4.14063590
79L-serine metabolic process (GO:0006563)4.11713156
80cellular glucuronidation (GO:0052695)4.09411530
81benzene-containing compound metabolic process (GO:0042537)4.08209897
82arginine metabolic process (GO:0006525)4.07397837
83low-density lipoprotein particle remodeling (GO:0034374)4.05079593
84cellular modified amino acid catabolic process (GO:0042219)4.03248838
85blood coagulation, intrinsic pathway (GO:0007597)4.02425982
86dicarboxylic acid biosynthetic process (GO:0043650)4.02312409
87aldehyde catabolic process (GO:0046185)4.02030012
88serine family amino acid biosynthetic process (GO:0009070)4.01073003
89drug catabolic process (GO:0042737)3.97595711
90ethanol oxidation (GO:0006069)3.95290286
91ketone body metabolic process (GO:1902224)3.94545329
92positive regulation of lipoprotein lipase activity (GO:0051006)3.89239167
93positive regulation of triglyceride lipase activity (GO:0061365)3.89239167
94tetrahydrofolate metabolic process (GO:0046653)3.87289376
95negative regulation of coagulation (GO:0050819)3.83089659
96cofactor catabolic process (GO:0051187)3.82209524
97negative regulation of lipase activity (GO:0060192)3.82181730
98response to mercury ion (GO:0046689)3.81211945
99phospholipid homeostasis (GO:0055091)3.81194165
100protein activation cascade (GO:0072376)3.80266441
101positive regulation of lipid catabolic process (GO:0050996)3.79146922
102cholesterol homeostasis (GO:0042632)3.78164791
103negative regulation of wound healing (GO:0061045)3.78039509
104very-low-density lipoprotein particle assembly (GO:0034379)3.77989216
105complement activation, classical pathway (GO:0006958)3.77653230
106complement activation (GO:0006956)3.77319793
107plasma lipoprotein particle organization (GO:0071827)3.76110953
108oxaloacetate metabolic process (GO:0006107)3.74575019
109sterol homeostasis (GO:0055092)3.71673854
110organic acid catabolic process (GO:0016054)3.71186958
111carboxylic acid catabolic process (GO:0046395)3.71186958
112protein-lipid complex assembly (GO:0065005)3.70773866
113regulation of bile acid biosynthetic process (GO:0070857)3.64941344
114glucuronate metabolic process (GO:0019585)3.62545067
115uronic acid metabolic process (GO:0006063)3.62545067
116regulation of cholesterol homeostasis (GO:2000188)3.59972047
117heme transport (GO:0015886)3.59897857
118acute-phase response (GO:0006953)3.59284141
119cytolysis (GO:0019835)3.59020403
120negative regulation of protein activation cascade (GO:2000258)3.58963959
121acetyl-CoA metabolic process (GO:0006084)3.58044223
122positive regulation of blood coagulation (GO:0030194)3.52579081
123positive regulation of hemostasis (GO:1900048)3.52579081
124xenobiotic catabolic process (GO:0042178)3.44082498
125negative regulation of complement activation (GO:0045916)3.43889481
126alkaloid metabolic process (GO:0009820)3.42976573
127hormone catabolic process (GO:0042447)3.37487180
128regulation of acute inflammatory response (GO:0002673)3.35720226
129sodium-independent organic anion transport (GO:0043252)3.35685420
130sulfur amino acid metabolic process (GO:0000096)3.30243419
131xenobiotic metabolic process (GO:0006805)3.28676858
132primary alcohol metabolic process (GO:0034308)3.27777871
133folic acid-containing compound metabolic process (GO:0006760)3.26009046
134folic acid-containing compound biosynthetic process (GO:0009396)3.23098138
135omega-hydroxylase P450 pathway (GO:0097267)10.1734601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.43552500
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22413621
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.97472231
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.51792461
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.33319706
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.20513661
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.88442666
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.05860766
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02938572
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08488124
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.1189792
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99348451
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91472934
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84530254
15GATA1_22025678_ChIP-Seq_K562_Human1.65601944
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.61713247
17CLOCK_20551151_ChIP-Seq_293T_Human1.57607815
18HTT_18923047_ChIP-ChIP_STHdh_Human1.56807005
19PHF8_20622853_ChIP-Seq_HELA_Human1.43324249
20HNF4A_19822575_ChIP-Seq_HepG2_Human1.40903800
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39319531
22CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33895966
23HNFA_21074721_ChIP-Seq_CACO-2_Human1.27189573
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25093557
25GATA6_21074721_ChIP-Seq_CACO-2_Human1.19744786
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19520196
27RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19492991
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14835651
29GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.12072206
30NFYA_21822215_ChIP-Seq_K562_Human1.09870794
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.07493899
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00043372
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97880651
34CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97229348
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96956875
36NFYB_21822215_ChIP-Seq_K562_Human0.96902232
37SOX2_22085726_ChIP-Seq_NPCs_Mouse0.96752331
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94452850
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93568345
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90908539
41ETV1_20927104_ChIP-Seq_GIST48_Human0.89819278
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89367237
43CDX2_22108803_ChIP-Seq_LS180_Human0.88479962
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88283715
45SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88084168
46PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.87563521
47AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86001254
48EZH2_27294783_Chip-Seq_NPCs_Mouse0.84594854
49TBL1_22424771_ChIP-Seq_293T_Human0.82917529
50RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81608539
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81126539
52SOX2_21211035_ChIP-Seq_LN229_Human0.81106734
53P300_27268052_Chip-Seq_Bcells_Human0.80075926
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79841541
55RBPJ_21746931_ChIP-Seq_IB4_Human0.79839499
56GATA4_25053715_ChIP-Seq_YYC3_Human0.79345050
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78799136
58IRF8_22096565_ChIP-ChIP_GC-B_Human0.78460059
59SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78459949
60TCF4_18268006_ChIP-ChIP_LS174T_Human0.78140509
61SPI1_20517297_ChIP-Seq_HL60_Human0.77814338
62SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75735618
63YY1_22570637_ChIP-Seq_MALME-3M_Human0.75700966
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.74953154
65ZNF263_19887448_ChIP-Seq_K562_Human0.74166371
66RARA_24833708_ChIP-Seq_LIVER_Mouse0.73541891
67E2F1_20622854_ChIP-Seq_HELA_Human0.72685051
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72493980
69KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72130145
70OCT1_27270436_Chip-Seq_PROSTATE_Human0.71866027
71ETV2_25802403_ChIP-Seq_MESCs_Mouse0.71414392
72* NCOR1_26117541_ChIP-Seq_K562_Human0.70836298
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69963054
74VDR_22108803_ChIP-Seq_LS180_Human0.69722750
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68338604
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68256363
77E2F7_22180533_ChIP-Seq_HELA_Human0.68058086
78FOXH1_21741376_ChIP-Seq_ESCs_Human0.67352066
79SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67346448
80P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.67276459
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66318361
82P68_20966046_ChIP-Seq_HELA_Human0.65904025
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65375327
84BCOR_27268052_Chip-Seq_Bcells_Human0.65348490
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.65245602
86CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64376466
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64328103
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63556996
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63455546
90CRX_20693478_ChIP-Seq_RETINA_Mouse0.62640889
91RARB_24833708_ChIP-Seq_LIVER_Mouse0.62469245
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62389431
93JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.61796481
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.61048631
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60948621
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.60185861
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.60185861
98RAC3_21632823_ChIP-Seq_H3396_Human0.59980321
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59947284
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.59400899
101* CTCF_27219007_Chip-Seq_Bcells_Human0.59104154
102TP53_18474530_ChIP-ChIP_U2OS_Human0.59035583
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.58512630
104ESR2_21235772_ChIP-Seq_MCF-7_Human0.58437055
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.58124692
106CEBPB_22108803_ChIP-Seq_LS180_Human0.57466441
107EGR1_19032775_ChIP-ChIP_M12_Human0.55816693
108LXR_22292898_ChIP-Seq_THP-1_Human0.55370516
109GATA1_19941826_ChIP-Seq_K562_Human0.55243512
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.52555393
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51864969
112AR_20517297_ChIP-Seq_VCAP_Human0.51827540
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.51094735
114MYC_19915707_ChIP-ChIP_AK7_Human0.51015001
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.50628282
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49412782
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49384199
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48978979
119CBP_21632823_ChIP-Seq_H3396_Human0.48633752
120P53_21459846_ChIP-Seq_SAOS-2_Human0.46650562
121ESET_19884257_ChIP-Seq_ESCs_Mouse0.45451509
122STAT1_17558387_ChIP-Seq_HELA_Human0.44766243
123PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43993898
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.43283962
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43153359
126TAF2_19829295_ChIP-Seq_ESCs_Human0.42856353
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42804720
128* GATA2_19941826_ChIP-Seq_K562_Human0.42790348
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40528195
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.39494670
131TAF15_26573619_Chip-Seq_HEK293_Human0.38924740
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38591933
133MYC_27129775_Chip-Seq_CORNEA_Mouse0.37956204
134GATA6_25053715_ChIP-Seq_YYC3_Human0.37668114
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.37520881
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.37506149
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.36719017
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.36428567
139STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.35970410
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.35943551
141LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35380003
142SPI1_26923725_Chip-Seq_HPCs_Mouse0.35195903
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.35039715
144BCAT_22108803_ChIP-Seq_LS180_Human0.35004533
145OCT4_20526341_ChIP-Seq_ESCs_Human0.34832948
146FOXH1_21741376_ChIP-Seq_EPCs_Human0.33967163
147ERG_20517297_ChIP-Seq_VCAP_Human0.33645169
148NCOR_22424771_ChIP-Seq_293T_Human0.33268144
149SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.32730553
150GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.32574571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.24266149
2MP0005360_urolithiasis7.51574629
3MP0005085_abnormal_gallbladder_physiolo6.43620683
4MP0005365_abnormal_bile_salt6.14568635
5MP0008875_abnormal_xenobiotic_pharmacok5.18186404
6MP0003806_abnormal_nucleotide_metabolis4.12834679
7MP0003252_abnormal_bile_duct3.87079138
8MP0010329_abnormal_lipoprotein_level3.63123455
9MP0009840_abnormal_foam_cell3.31603610
10MP0005083_abnormal_biliary_tract3.18430163
11MP0003195_calcinosis2.82557318
12MP0005332_abnormal_amino_acid2.73571723
13MP0001666_abnormal_nutrient_absorption2.58113723
14MP0003191_abnormal_cellular_cholesterol2.48181220
15MP0000609_abnormal_liver_physiology2.18847868
16MP0004019_abnormal_vitamin_homeostasis2.14909775
17MP0002118_abnormal_lipid_homeostasis2.10162880
18MP0002138_abnormal_hepatobiliary_system1.94807486
19MP0003868_abnormal_feces_composition1.89742215
20MP0005319_abnormal_enzyme/_coenzyme1.83775129
21MP0001764_abnormal_homeostasis1.67144985
22MP0009697_abnormal_copulation1.60639642
23MP0003011_delayed_dark_adaptation1.59447551
24MP0005584_abnormal_enzyme/coenzyme_acti1.57307866
25MP0003656_abnormal_erythrocyte_physiolo1.52870964
26MP0005451_abnormal_body_composition1.45517875
27MP0008995_early_reproductive_senescence1.34085931
28MP0005646_abnormal_pituitary_gland1.30423431
29MP0003186_abnormal_redox_activity1.27203125
30MP0009643_abnormal_urine_homeostasis1.22005300
31MP0000598_abnormal_liver_morphology1.20696799
32MP0003705_abnormal_hypodermis_morpholog1.18827616
33MP0005647_abnormal_sex_gland1.11414025
34MP0010368_abnormal_lymphatic_system1.10186006
35MP0000604_amyloidosis1.10174165
36MP0002254_reproductive_system_inflammat1.05264977
37MP0009764_decreased_sensitivity_to1.04869514
38MP0009763_increased_sensitivity_to1.03713842
39MP0005636_abnormal_mineral_homeostasis0.96384884
40MP0003183_abnormal_peptide_metabolism0.92137402
41MP0002282_abnormal_trachea_morphology0.91792750
42MP0008775_abnormal_heart_ventricle0.90316884
43MP0008469_abnormal_protein_level0.89756119
44MP0009642_abnormal_blood_homeostasis0.87774241
45MP0005670_abnormal_white_adipose0.87250143
46MP0006036_abnormal_mitochondrial_physio0.83199621
47MP0005408_hypopigmentation0.81502496
48MP0005376_homeostasis/metabolism_phenot0.80651222
49MP0009765_abnormal_xenobiotic_induced0.78002626
50MP0002078_abnormal_glucose_homeostasis0.77895705
51MP0002249_abnormal_larynx_morphology0.77616950
52MP0005084_abnormal_gallbladder_morpholo0.74294582
53MP0000013_abnormal_adipose_tissue0.73436105
54MP0005220_abnormal_exocrine_pancreas0.72902720
55MP0002971_abnormal_brown_adipose0.71874405
56MP0001661_extended_life_span0.71392998
57MP0002876_abnormal_thyroid_physiology0.69627324
58MP0009053_abnormal_anal_canal0.68654373
59MP0004130_abnormal_muscle_cell0.68424867
60MP0003690_abnormal_glial_cell0.66766108
61MP0005334_abnormal_fat_pad0.66666292
62MP0000678_abnormal_parathyroid_gland0.65685761
63MP0005535_abnormal_body_temperature0.65296276
64MP0003879_abnormal_hair_cell0.63902787
65MP0005266_abnormal_metabolism0.63714860
66MP0000639_abnormal_adrenal_gland0.63409222
67MP0001851_eye_inflammation0.61869969
68MP0003329_amyloid_beta_deposits0.60337098
69MP0005464_abnormal_platelet_physiology0.60333895
70MP0001756_abnormal_urination0.59889434
71MP0002736_abnormal_nociception_after0.58226147
72MP0005448_abnormal_energy_balance0.56514800
73MP0006035_abnormal_mitochondrial_morpho0.55951386
74MP0002295_abnormal_pulmonary_circulatio0.52137330
75MP0004145_abnormal_muscle_electrophysio0.52005683
76MP0002332_abnormal_exercise_endurance0.51738584
77MP0005187_abnormal_penis_morphology0.49846739
78MP0005395_other_phenotype0.48850700
79MP0004036_abnormal_muscle_relaxation0.48822637
80MP0003638_abnormal_response/metabolism_0.46037565
81MP0008874_decreased_physiological_sensi0.45739938
82MP0008873_increased_physiological_sensi0.45532748
83MP0004782_abnormal_surfactant_physiolog0.45341684
84MP0002928_abnormal_bile_duct0.44836022
85MP0003718_maternal_effect0.44742839
86MP0002822_catalepsy0.44261390
87MP0003436_decreased_susceptibility_to0.44231510
88MP0002136_abnormal_kidney_physiology0.44113861
89MP0001944_abnormal_pancreas_morphology0.43806363
90MP0005248_abnormal_Harderian_gland0.43577909
91MP0002837_dystrophic_cardiac_calcinosis0.42360995
92MP0008872_abnormal_physiological_respon0.42212998
93MP0004084_abnormal_cardiac_muscle0.40506484
94MP0003075_altered_response_to0.40427848
95MP0003724_increased_susceptibility_to0.40256417
96MP0003953_abnormal_hormone_level0.39628420
97MP0005385_cardiovascular_system_phenoty0.39572026
98MP0001544_abnormal_cardiovascular_syste0.39572026
99MP0005330_cardiomyopathy0.39302794
100MP0009672_abnormal_birth_weight0.39302704
101MP0005397_hematopoietic_system_phenotyp0.38926811
102MP0001545_abnormal_hematopoietic_system0.38926811
103MP0009384_cardiac_valve_regurgitation0.38627902
104MP0005666_abnormal_adipose_tissue0.37174090
105MP0002269_muscular_atrophy0.36287971
106MP0005023_abnormal_wound_healing0.36231589
107MP0004883_abnormal_blood_vessel0.35804782
108MP0004885_abnormal_endolymph0.35285331
109MP0005166_decreased_susceptibility_to0.34630168
110MP0009785_altered_susceptibility_to0.34313225
111MP0002128_abnormal_blood_circulation0.34308251
112MP0000249_abnormal_blood_vessel0.33403816
113MP0000371_diluted_coat_color0.32895387
114MP0001243_abnormal_dermal_layer0.32654442
115MP0009115_abnormal_fat_cell0.32275518
116MP0000230_abnormal_systemic_arterial0.32074185
117MP0010630_abnormal_cardiac_muscle0.31784184
118MP0001915_intracranial_hemorrhage0.31456549
119MP0000579_abnormal_nail_morphology0.30851453
120MP0002970_abnormal_white_adipose0.30716812
121MP0004381_abnormal_hair_follicle0.30495705
122MP0004147_increased_porphyrin_level0.30476106
123MP0002168_other_aberrant_phenotype0.30391144
124MP0005551_abnormal_eye_electrophysiolog0.29282923
125MP0002796_impaired_skin_barrier0.29201571
126MP0005164_abnormal_response_to0.28272879
127MP0002090_abnormal_vision0.28051424
128MP0001853_heart_inflammation0.27730248
129MP0001845_abnormal_inflammatory_respons0.27327163
130MP0006082_CNS_inflammation0.26541256
131MP0002132_abnormal_respiratory_system0.26179268
132MP0001881_abnormal_mammary_gland0.25292809

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.57825964
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.42426689
3Intrahepatic cholestasis (HP:0001406)7.24127680
4Prolonged partial thromboplastin time (HP:0003645)6.73855098
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.67559083
6Hypobetalipoproteinemia (HP:0003563)6.41224962
7Xanthomatosis (HP:0000991)6.30383807
8Hyperlipoproteinemia (HP:0010980)5.61232613
9Complement deficiency (HP:0004431)5.42397639
10Joint hemorrhage (HP:0005261)4.94878727
11Hypolipoproteinemia (HP:0010981)4.91648529
12Abnormality of the common coagulation pathway (HP:0010990)4.61505083
13Hyperammonemia (HP:0001987)4.58322899
14Abnormality of alanine metabolism (HP:0010916)4.50021224
15Hyperalaninemia (HP:0003348)4.50021224
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.50021224
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.47967821
18Epidermoid cyst (HP:0200040)4.44942171
19Hypoalphalipoproteinemia (HP:0003233)4.40963676
20Abnormality of methionine metabolism (HP:0010901)4.33264360
21Hyperglycinemia (HP:0002154)4.30236444
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.24628593
23Ketosis (HP:0001946)4.24102536
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12608684
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08716439
26Fat malabsorption (HP:0002630)4.03318547
27Abnormality of complement system (HP:0005339)3.96638106
28Abnormality of the intrinsic pathway (HP:0010989)3.85392478
29Abnormality of pyrimidine metabolism (HP:0004353)3.85304107
30Hypoglycemic coma (HP:0001325)3.84543316
31Hyperglycinuria (HP:0003108)3.80846243
32Abnormality of serine family amino acid metabolism (HP:0010894)3.80832865
33Abnormality of glycine metabolism (HP:0010895)3.80832865
34Conjugated hyperbilirubinemia (HP:0002908)3.65467472
35Hypercholesterolemia (HP:0003124)3.61174477
36Hyperbilirubinemia (HP:0002904)3.50017267
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30730126
38Abnormality of fatty-acid metabolism (HP:0004359)3.28386381
39Hypochromic microcytic anemia (HP:0004840)3.27802458
40Spontaneous abortion (HP:0005268)3.22355020
41Purpura (HP:0000979)3.16288412
42Hepatocellular carcinoma (HP:0001402)3.14935358
43Abnormality of nucleobase metabolism (HP:0010932)3.05059018
44Delayed CNS myelination (HP:0002188)3.03042610
45Steatorrhea (HP:0002570)3.02515794
46Abnormality of serum amino acid levels (HP:0003112)3.00184418
47Ketoacidosis (HP:0001993)2.93801065
48Myocardial infarction (HP:0001658)2.91409682
49Metabolic acidosis (HP:0001942)2.77479864
50Systemic lupus erythematosus (HP:0002725)2.76864387
51Skin nodule (HP:0200036)2.76634919
52Acanthocytosis (HP:0001927)2.74381269
53Abnormal gallbladder morphology (HP:0012437)2.65598703
54Abnormality of purine metabolism (HP:0004352)2.64936474
55Cholelithiasis (HP:0001081)2.61471528
56Vascular calcification (HP:0004934)2.58377747
57Lethargy (HP:0001254)2.58354052
58Glomerulonephritis (HP:0000099)2.58030464
59Neonatal hypoglycemia (HP:0001998)2.54520283
60Cholecystitis (HP:0001082)2.53087021
61Abnormal gallbladder physiology (HP:0012438)2.53087021
62Elevated alkaline phosphatase (HP:0003155)2.52530491
63Abnormality of homocysteine metabolism (HP:0010919)2.51411535
64Homocystinuria (HP:0002156)2.51411535
65Anorexia (HP:0002039)2.50609624
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50229593
67Dicarboxylic aciduria (HP:0003215)2.50229593
68Congenital sensorineural hearing impairment (HP:0008527)2.48907389
69Mitral stenosis (HP:0001718)2.46844149
70Hypoglycemic seizures (HP:0002173)2.46552711
71Gout (HP:0001997)2.46296871
72Cerebral edema (HP:0002181)2.43729593
73Spastic diplegia (HP:0001264)2.43045352
74Amyloidosis (HP:0011034)2.41728163
75Hyperphosphaturia (HP:0003109)2.40856436
76Recurrent gram-negative bacterial infections (HP:0005420)2.36983148
77Gingival bleeding (HP:0000225)2.36468689
78Irritability (HP:0000737)2.34042483
79Neonatal onset (HP:0003623)2.32212414
80Poikilocytosis (HP:0004447)2.31443843
81Abnormality of alkaline phosphatase activity (HP:0004379)2.29955327
82Cardiovascular calcification (HP:0011915)2.29313239
83Osteomalacia (HP:0002749)2.28434745
84Menorrhagia (HP:0000132)2.24923111
85Increased mean platelet volume (HP:0011877)2.18683873
86Enlarged kidneys (HP:0000105)2.17664508
87Malnutrition (HP:0004395)2.15353833
88* Pulmonary embolism (HP:0002204)2.13776347
89Brushfield spots (HP:0001088)2.13402893
90Pancreatitis (HP:0001733)2.12984087
91Abnormality of the gallbladder (HP:0005264)2.12743589
92Constricted visual fields (HP:0001133)2.11254739
93Sensorimotor neuropathy (HP:0007141)2.10876124
94Late onset (HP:0003584)2.09274223
95Vomiting (HP:0002013)2.07033112
96Hemorrhage of the eye (HP:0011885)2.03840438
97Fair hair (HP:0002286)2.02009565
98Opisthotonus (HP:0002179)2.01472258
99Generalized aminoaciduria (HP:0002909)1.99703759
100* Epistaxis (HP:0000421)1.99435567
101Hyperinsulinemic hypoglycemia (HP:0000825)1.98857688
102Abnormal platelet volume (HP:0011876)1.97717611
103Abnormality of iron homeostasis (HP:0011031)1.97617038
104Rickets (HP:0002748)1.93964630
105* Thrombophlebitis (HP:0004418)1.93714885
106Abnormality of transition element cation homeostasis (HP:0011030)1.92272448
107Reticulocytosis (HP:0001923)1.91536665
108Abnormal urine phosphate concentration (HP:0012599)1.91487319
109Abnormal cartilage morphology (HP:0002763)1.88340076
110Decreased subcutaneous fat (HP:0001002)1.87006207
111Hypophosphatemic rickets (HP:0004912)1.86353282
112Glycosuria (HP:0003076)1.84685286
113Abnormality of urine glucose concentration (HP:0011016)1.84685286
114Birth length less than 3rd percentile (HP:0003561)1.84551221
115Nephritis (HP:0000123)1.83065211
116Increased serum pyruvate (HP:0003542)1.82708670
117Renal cortical cysts (HP:0000803)1.80276966
118Abnormality of proline metabolism (HP:0010907)1.79338945
119Hydroxyprolinuria (HP:0003080)1.79338945
120Status epilepticus (HP:0002133)1.78346394
121Alkalosis (HP:0001948)1.78174655
122Abnormal enzyme/coenzyme activity (HP:0012379)1.76979059
123Acute hepatic failure (HP:0006554)1.74140307
124* Elevated hepatic transaminases (HP:0002910)1.73896578
125Abnormal tarsal ossification (HP:0008369)1.73581153
126* Esophageal varix (HP:0002040)1.73525781
127Ileus (HP:0002595)1.72645101
128Hyperglycemia (HP:0003074)1.70291704
129White forelock (HP:0002211)1.68526134
130Back pain (HP:0003418)1.67765207
131Arthropathy (HP:0003040)1.67750086
132Arterial thrombosis (HP:0004420)1.64030360
133Abnormal platelet function (HP:0011869)1.63648611
134Impaired platelet aggregation (HP:0003540)1.63648611
135Petechiae (HP:0000967)1.62227687
136Atrioventricular block (HP:0001678)1.59829925
137Hypoparathyroidism (HP:0000829)1.59458321
138Abnormality of glycolysis (HP:0004366)1.58947250
139Metaphyseal cupping (HP:0003021)1.58475298
140Cerebral palsy (HP:0100021)1.56691945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.16899021
2FGFR44.68165476
3ERN14.49142537
4SIK14.45358204
5NTRK33.80429549
6JAK33.48064841
7RPS6KB23.24413874
8TAOK33.03816354
9INSRR2.90749793
10ERBB42.86956226
11ACVR1B2.54780597
12MAP2K42.37551142
13PKN22.28171213
14MST1R2.21190055
15RIPK42.20041799
16CDK92.18798170
17FGR2.17340604
18MAPK111.98286775
19FLT31.91170216
20CCNB11.87736068
21NTRK21.84006757
22TRIB31.82166089
23TYK21.81313155
24MYLK1.75719699
25DAPK21.62326385
26PIK3CG1.62153279
27LATS11.51766653
28ABL21.49243154
29PTK61.48286873
30KDR1.47471000
31EPHA31.45822773
32OBSCN1.42963927
33NEK91.39418791
34MAPKAPK31.38288812
35FRK1.34806259
36PINK11.33802993
37EPHB21.32762898
38LMTK21.31862185
39FGFR21.31460216
40MAP2K31.27520083
41JAK21.26041795
42MAP4K11.23716050
43GRK71.17045226
44GRK61.14470774
45MAP3K71.14205770
46PRKAA21.13553777
47ERBB21.11071771
48ADRBK11.06801766
49STK38L1.03200807
50JAK11.01715359
51MAPK40.97444181
52TESK20.96414201
53TBK10.96401228
54BMPR20.95883720
55EPHB10.95571634
56TIE10.90753429
57MAP3K30.90539713
58PRKCZ0.89946312
59MET0.88071510
60MAPK120.86207039
61MAP3K100.85876474
62KSR20.85685314
63CDC70.85425239
64MAP3K110.84914477
65PBK0.81754598
66MAP3K140.81244441
67TEC0.80907761
68PRKACG0.80491561
69CDK60.75653588
70AKT30.71355501
71CSK0.71087366
72RIPK10.69127990
73DYRK1B0.68917204
74WNK40.68680746
75MAPK150.67513548
76CAMK2G0.67105724
77BLK0.66755852
78PAK40.65992732
79SGK30.65048147
80PRKAA10.64919799
81TGFBR20.63820481
82GSK3A0.62912186
83MAP2K60.61937659
84RPS6KB10.61476768
85AURKA0.61187401
86CDK70.60642982
87CAMK1D0.60482641
88BRSK20.60092668
89FGFR30.58405864
90MAPK70.57590955
91TNK20.57430750
92RAF10.56616587
93CSNK1A10.55681937
94PRKD10.53812773
95TRPM70.53423228
96PTK20.52961571
97CAMK10.52749469
98CSF1R0.51871758
99PAK10.50977528
100SGK10.50410067
101SGK20.48138737
102NEK60.47131942
103IKBKE0.46914451
104PRKCQ0.46675857
105DYRK20.46606493
106EPHA40.46479273
107GRK10.46394502
108PDPK10.45131627
109TAOK20.44732820
110CDK40.44698448
111MAP3K50.41672898
112IGF1R0.41129462
113CSNK1G10.40891769
114AKT20.40472130
115RET0.39885049
116PRKCG0.39357928
117MAP2K10.39215802
118CSNK2A10.38956613
119PKN10.38415999
120HIPK20.37476720
121MTOR0.36474149
122SGK4940.35388457
123SGK2230.35388457
124SRC0.35020615
125IRAK30.35015213
126ICK0.34984121
127CAMK2D0.34718380
128MATK0.34652453
129MAP3K60.34594459
130PRKG10.34302421
131BTK0.34088417
132SYK0.33654874
133EGFR0.32569396
134MAP3K130.32542157
135MAP3K10.31728636
136CAMK40.29552156
137DAPK10.28625402
138PRKCA0.26230966
139PDK10.26138822
140LATS20.22952791
141EIF2AK10.21287917
142CSNK1G20.19618805
143MAPK30.18793984
144PRKACB0.18717153
145ABL10.17993071
146BMX0.17728615
147CSNK1G30.17679765
148PRKACA0.16214942
149PIK3CA0.16143075
150RPS6KA30.16027488

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.49730540
2Nitrogen metabolism_Homo sapiens_hsa009103.69031128
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.47480101
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28386510
5Arginine biosynthesis_Homo sapiens_hsa002203.09280335
6Complement and coagulation cascades_Homo sapiens_hsa046102.86989518
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68680079
8Tryptophan metabolism_Homo sapiens_hsa003802.66758317
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63463305
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57899684
11Fatty acid degradation_Homo sapiens_hsa000712.47006799
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35513508
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18671824
14Butanoate metabolism_Homo sapiens_hsa006502.13741042
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09877764
16Peroxisome_Homo sapiens_hsa041462.05126011
17Chemical carcinogenesis_Homo sapiens_hsa052041.92899142
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.90531565
19Propanoate metabolism_Homo sapiens_hsa006401.88903737
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88504424
21PPAR signaling pathway_Homo sapiens_hsa033201.86660803
22Histidine metabolism_Homo sapiens_hsa003401.86529720
23Staphylococcus aureus infection_Homo sapiens_hsa051501.83770841
24Fatty acid metabolism_Homo sapiens_hsa012121.80915875
25Caffeine metabolism_Homo sapiens_hsa002321.76534179
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74665014
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.73183677
28Retinol metabolism_Homo sapiens_hsa008301.68492078
29beta-Alanine metabolism_Homo sapiens_hsa004101.67823980
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66380370
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60848185
32Phenylalanine metabolism_Homo sapiens_hsa003601.58520885
33Selenocompound metabolism_Homo sapiens_hsa004501.57414266
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54077340
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53345520
36Bile secretion_Homo sapiens_hsa049761.49319852
37Tyrosine metabolism_Homo sapiens_hsa003501.44008423
38Pyruvate metabolism_Homo sapiens_hsa006201.35312533
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.33665075
40Fatty acid elongation_Homo sapiens_hsa000621.32779311
41Sulfur metabolism_Homo sapiens_hsa009201.32575368
42Starch and sucrose metabolism_Homo sapiens_hsa005001.25587925
43Biosynthesis of amino acids_Homo sapiens_hsa012301.23544604
44ABC transporters_Homo sapiens_hsa020101.21953806
45Steroid biosynthesis_Homo sapiens_hsa001001.20123808
46Folate biosynthesis_Homo sapiens_hsa007901.19243189
47Fat digestion and absorption_Homo sapiens_hsa049751.16917450
48Carbon metabolism_Homo sapiens_hsa012001.14103914
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09783917
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02844323
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.01999335
52Vitamin B6 metabolism_Homo sapiens_hsa007501.01522873
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.00466815
54Sulfur relay system_Homo sapiens_hsa041220.96240456
55Arginine and proline metabolism_Homo sapiens_hsa003300.95800067
56Vitamin digestion and absorption_Homo sapiens_hsa049770.87446162
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86484892
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85435737
59Lysine degradation_Homo sapiens_hsa003100.80413127
60One carbon pool by folate_Homo sapiens_hsa006700.80030534
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71792665
62Glycerolipid metabolism_Homo sapiens_hsa005610.65114947
63Glutathione metabolism_Homo sapiens_hsa004800.63410358
64Pentose phosphate pathway_Homo sapiens_hsa000300.58887233
65Fatty acid biosynthesis_Homo sapiens_hsa000610.50730140
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48620180
67Metabolic pathways_Homo sapiens_hsa011000.46163909
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38808538
69Prion diseases_Homo sapiens_hsa050200.33979762
70Serotonergic synapse_Homo sapiens_hsa047260.30754863
71Pertussis_Homo sapiens_hsa051330.30706057
72Galactose metabolism_Homo sapiens_hsa000520.26265321
73Fructose and mannose metabolism_Homo sapiens_hsa000510.25521752
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24227059
75Insulin resistance_Homo sapiens_hsa049310.23028782
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22784066
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.21871513
78Linoleic acid metabolism_Homo sapiens_hsa005910.21594384
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.14915692
80GABAergic synapse_Homo sapiens_hsa047270.13573411
81Glucagon signaling pathway_Homo sapiens_hsa049220.10788671
82Mineral absorption_Homo sapiens_hsa049780.07506049
83Other glycan degradation_Homo sapiens_hsa005110.05017866
84Collecting duct acid secretion_Homo sapiens_hsa049660.02343052
85AMPK signaling pathway_Homo sapiens_hsa041520.02125426
86Amoebiasis_Homo sapiens_hsa05146-0.2562487
87Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2513758
88Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2431134
89Bladder cancer_Homo sapiens_hsa05219-0.2414438
90Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2238299
91Glutamatergic synapse_Homo sapiens_hsa04724-0.2045368
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1944763
93Renin-angiotensin system_Homo sapiens_hsa04614-0.1882178
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1848281
95Nicotine addiction_Homo sapiens_hsa05033-0.1837241
96Hepatitis C_Homo sapiens_hsa05160-0.1834599
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1713218
98Retrograde endocannabinoid signaling_Homo sapiens_hsa04723-0.1637894
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1632146
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1604897
101Platelet activation_Homo sapiens_hsa04611-0.1599671
102Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1593154
103Regulation of autophagy_Homo sapiens_hsa04140-0.1523344
104Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1503710
105African trypanosomiasis_Homo sapiens_hsa05143-0.1400862
106Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1247559
107Insulin signaling pathway_Homo sapiens_hsa04910-0.0993134
108Morphine addiction_Homo sapiens_hsa05032-0.0980582
109Type II diabetes mellitus_Homo sapiens_hsa04930-0.0898667
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0836440
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0770338
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0713090
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0399783

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