GDF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.05515354
2maintenance of protein location in nucleus (GO:0051457)6.55203646
3regulation of nuclear cell cycle DNA replication (GO:0033262)6.43948504
4protein localization to kinetochore (GO:0034501)6.40624336
5regulation of mammary gland epithelial cell proliferation (GO:0033599)6.31120300
6nodal signaling pathway (GO:0038092)6.17815557
7regulation of telomere maintenance via telomerase (GO:0032210)6.03251675
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.00483147
9negative regulation of telomerase activity (GO:0051974)5.84110556
10positive regulation of SMAD protein import into nucleus (GO:0060391)5.75641693
11histone H4-K12 acetylation (GO:0043983)5.72780792
12regulation of response to osmotic stress (GO:0047484)5.63097063
13histone H4-K8 acetylation (GO:0043982)5.58267800
14histone H4-K5 acetylation (GO:0043981)5.58267800
15negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.48651377
16rRNA transcription (GO:0009303)5.43915873
17negative regulation of cell cycle G2/M phase transition (GO:1902750)5.43479600
18muscle organ morphogenesis (GO:0048644)5.23466146
19regulation of MHC class I biosynthetic process (GO:0045343)5.20411195
20mitotic sister chromatid segregation (GO:0000070)5.12342042
21rRNA methylation (GO:0031167)5.01027730
22negative regulation of androgen receptor signaling pathway (GO:0060766)4.95310830
23DNA replication-dependent nucleosome assembly (GO:0006335)4.88343958
24DNA replication-dependent nucleosome organization (GO:0034723)4.88343958
25cell migration involved in gastrulation (GO:0042074)4.86831879
26rRNA modification (GO:0000154)4.82436029
27chromatin remodeling at centromere (GO:0031055)4.77751762
28protein localization to chromosome, centromeric region (GO:0071459)4.76866183
29regulation of mesoderm development (GO:2000380)4.75629529
30positive regulation of DNA-dependent DNA replication (GO:2000105)4.70348640
31CENP-A containing nucleosome assembly (GO:0034080)4.69707521
32heterochromatin organization (GO:0070828)4.66434785
33DNA replication checkpoint (GO:0000076)4.61698301
34negative regulation of telomere maintenance (GO:0032205)4.53868394
35regulation of translation in response to stress (GO:0043555)4.51686131
36nuclear pore complex assembly (GO:0051292)4.51400315
37regulation of cilium movement (GO:0003352)4.50513993
38proteasome assembly (GO:0043248)4.45489064
39cytidine metabolic process (GO:0046087)4.34678266
40cytidine catabolic process (GO:0006216)4.34678266
41cytidine deamination (GO:0009972)4.34678266
42nucleoside transmembrane transport (GO:1901642)4.28830599
43chaperone-mediated protein transport (GO:0072321)4.24150010
44chromatin assembly (GO:0031497)4.23152898
45sister chromatid segregation (GO:0000819)4.22718233
46female gonad development (GO:0008585)4.22007907
47regulation of SMAD protein import into nucleus (GO:0060390)4.21008602
48regulation of apoptotic process involved in morphogenesis (GO:1902337)4.17433213
49quinone metabolic process (GO:1901661)4.15012762
50phenol-containing compound catabolic process (GO:0019336)4.12999144
51establishment of integrated proviral latency (GO:0075713)4.11518117
52nuclear pore organization (GO:0006999)4.09010374
53histone H4-K16 acetylation (GO:0043984)4.08093350
54hormone catabolic process (GO:0042447)4.05814157
55interferon-gamma production (GO:0032609)4.02420646
56branching involved in mammary gland duct morphogenesis (GO:0060444)3.99493320
57lung-associated mesenchyme development (GO:0060484)3.95719648
58cell fate commitment involved in formation of primary germ layer (GO:0060795)3.95104123
59histone exchange (GO:0043486)3.93695957
60cullin deneddylation (GO:0010388)3.91061639
61ribosome biogenesis (GO:0042254)3.90147097
62mitotic metaphase plate congression (GO:0007080)3.80764185
63lung morphogenesis (GO:0060425)3.80540044
64DNA replication-independent nucleosome organization (GO:0034724)3.77309681
65DNA replication-independent nucleosome assembly (GO:0006336)3.77309681
66protein complex localization (GO:0031503)3.77022479
67regulation of posttranscriptional gene silencing (GO:0060147)3.76068398
68regulation of gene silencing by miRNA (GO:0060964)3.76068398
69regulation of gene silencing by RNA (GO:0060966)3.76068398
70regulation of timing of cell differentiation (GO:0048505)3.75044805
71coenzyme catabolic process (GO:0009109)3.74967200
72embryonic process involved in female pregnancy (GO:0060136)3.73703562
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.70361502
74anterior/posterior axis specification, embryo (GO:0008595)3.70332877
75formation of translation preinitiation complex (GO:0001731)3.68349133
76establishment of protein localization to mitochondrial membrane (GO:0090151)3.66911927
77regulation of telomerase activity (GO:0051972)3.63831826
78regulation of telomere maintenance (GO:0032204)3.62770449
79intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.62039510
80pre-miRNA processing (GO:0031054)3.58856286
81pseudouridine synthesis (GO:0001522)3.58401487
82transcription from mitochondrial promoter (GO:0006390)3.57250508
83maintenance of protein localization in organelle (GO:0072595)3.57034776
84regulation of activin receptor signaling pathway (GO:0032925)3.56958706
85regulation of development, heterochronic (GO:0040034)3.56251048
86intestinal epithelial cell development (GO:0060576)3.54862444
87GDP-mannose metabolic process (GO:0019673)3.52923927
88regulation of stem cell maintenance (GO:2000036)3.52398333
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52048919
90protein deneddylation (GO:0000338)3.45196491
91DNA damage response, detection of DNA damage (GO:0042769)3.44360210
92DNA duplex unwinding (GO:0032508)3.44015525
93digestive tract morphogenesis (GO:0048546)3.41476265
94pore complex assembly (GO:0046931)3.40481406
95DNA geometric change (GO:0032392)3.40186276
96negative regulation of ligase activity (GO:0051352)3.39925110
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.39925110
98IMP biosynthetic process (GO:0006188)3.39348761
99ribosome assembly (GO:0042255)3.38271573
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36477289
101mitochondrion distribution (GO:0048311)3.36028115
102cellular protein complex localization (GO:0034629)3.35208781
103L-serine metabolic process (GO:0006563)3.34412837
104regulation of gastrulation (GO:0010470)3.33532920
105cardiovascular system development (GO:0072358)3.32435918
106morphogenesis of an epithelial fold (GO:0060571)3.30843085
107cellular modified amino acid catabolic process (GO:0042219)3.30093758
108positive regulation of protein deacetylation (GO:0090312)3.28212706
109regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.27676691
110positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27576943
111mRNA stabilization (GO:0048255)3.26608306
112RNA stabilization (GO:0043489)3.26608306
113mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21669470
114metaphase plate congression (GO:0051310)3.21526427
115termination of RNA polymerase III transcription (GO:0006386)3.17064071
116transcription elongation from RNA polymerase III promoter (GO:0006385)3.17064071
117* negative regulation of epidermis development (GO:0045683)3.16858307
118mitotic chromosome condensation (GO:0007076)3.16401864
119nucleoside transport (GO:0015858)3.16069936
120retinoic acid receptor signaling pathway (GO:0048384)3.15742184
121DNA replication initiation (GO:0006270)3.15249276
122ventricular cardiac muscle cell development (GO:0055015)3.14772052
123trophectodermal cell differentiation (GO:0001829)3.14499264
124regulation of helicase activity (GO:0051095)3.14046299
125DNA unwinding involved in DNA replication (GO:0006268)3.13501570
126mitochondrial DNA replication (GO:0006264)3.12286949
127regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.11255568
128mitochondrial RNA metabolic process (GO:0000959)3.10873636
129blastocyst development (GO:0001824)3.10597468
130kinetochore organization (GO:0051383)3.10518402
131negative regulation of gene silencing (GO:0060969)3.09965031
132establishment of viral latency (GO:0019043)3.09526281
133ribosomal small subunit biogenesis (GO:0042274)3.09192408
134kinetochore assembly (GO:0051382)3.08629674
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08554306
136apoptotic DNA fragmentation (GO:0006309)3.07522728
137negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.06689329
138intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.06645298
139regulation of DNA-dependent DNA replication (GO:0090329)3.06095545
140regulation of double-strand break repair (GO:2000779)3.06038421
141DNA double-strand break processing (GO:0000729)3.04145312
142maternal placenta development (GO:0001893)3.04110903
143vitamin A metabolic process (GO:0006776)3.03976403
144activin receptor signaling pathway (GO:0032924)3.01963067
145SMAD protein signal transduction (GO:0060395)3.01582338
146nucleobase biosynthetic process (GO:0046112)3.01384281
147bone trabecula formation (GO:0060346)3.00203286
148ribonucleoprotein complex biogenesis (GO:0022613)2.99997944
149microtubule severing (GO:0051013)2.98213135
150purine nucleobase biosynthetic process (GO:0009113)2.98184659
151DNA strand elongation involved in DNA replication (GO:0006271)2.97480085
152epoxygenase P450 pathway (GO:0019373)2.97194235
153protein polyglutamylation (GO:0018095)2.95844504
154negative regulation of cell fate commitment (GO:0010454)2.95515018
155* somite rostral/caudal axis specification (GO:0032525)2.93932692
156ribosomal small subunit assembly (GO:0000028)2.90744289
157negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88017917
158negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88017917
159negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88017917
160negative regulation of mitotic sister chromatid separation (GO:2000816)2.88017917
161negative regulation of sister chromatid segregation (GO:0033046)2.88017917
162negative regulation of activin receptor signaling pathway (GO:0032926)2.87916452
163negative regulation of chromosome segregation (GO:0051985)2.86763046
164exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85802520
165IMP metabolic process (GO:0046040)2.84118493
166serine family amino acid biosynthetic process (GO:0009070)2.82881631
167protein neddylation (GO:0045116)2.82689026
168DNA strand elongation (GO:0022616)2.82480034
169spliceosomal snRNP assembly (GO:0000387)2.80735193
170positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79989399
171signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79611288
172signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79611288
173signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79611288
174oxidative phosphorylation (GO:0006119)2.78741651
175DNA ligation (GO:0006266)2.78163481
176regulation of cellular amino acid metabolic process (GO:0006521)2.77340173
177DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75704314
178nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75353424
179mitotic spindle checkpoint (GO:0071174)2.73993934
180positive regulation of ligase activity (GO:0051351)2.73590184
181regulation of ubiquitin-protein transferase activity (GO:0051438)2.73056400
182daunorubicin metabolic process (GO:0044597)10.9031128
183polyketide metabolic process (GO:0030638)10.9031128
184doxorubicin metabolic process (GO:0044598)10.9031128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.14323482
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.14323482
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.14323482
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.67992629
5E2F7_22180533_ChIP-Seq_HELA_Human5.56453515
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.21546877
7* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.17158201
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.98800364
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97577587
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.88773087
11* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.80762377
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71009255
13* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.66959586
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46166571
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.43848849
16* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.42968705
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.42942221
18* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.38973766
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36598413
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.16961673
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.13515362
22NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.13037209
23STAT3_1855785_ChIP-Seq_MESCs_Mouse1.98366729
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97887973
25* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97447110
26POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.96120884
27ELK1_19687146_ChIP-ChIP_HELA_Human1.93693632
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93467451
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91865390
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87211394
31IRF1_19129219_ChIP-ChIP_H3396_Human1.85554709
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83731854
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82891768
34* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.81327374
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80743306
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.80177194
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79837112
38* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.78192187
39DCP1A_22483619_ChIP-Seq_HELA_Human1.75785954
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70584641
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67982682
42POU5F1_16518401_ChIP-PET_MESCs_Mouse1.64330897
43* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64027224
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58894549
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.58792938
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57184589
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55506818
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54506486
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53570202
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49960909
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47821252
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47326134
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46930064
54* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.46852023
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45452080
56* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.44542066
57* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.42881517
58* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.40913570
59* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39591308
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38699358
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.34734747
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33724035
63* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.33651985
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.32286921
65* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28688125
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.26910147
67PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.26720481
68* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.26171833
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.25375439
70MYC_22102868_ChIP-Seq_BL_Human1.24041908
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22844419
72VDR_22108803_ChIP-Seq_LS180_Human1.21952706
73E2F1_17053090_ChIP-ChIP_MCF-7_Human1.18012351
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17032910
75* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16272069
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16063116
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15377433
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13801902
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13400973
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.11674568
81* NANOG_16518401_ChIP-PET_MESCs_Mouse1.11335273
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10120537
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07484205
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07065455
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.06135527
86* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05957404
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05672903
88SOX17_20123909_ChIP-Seq_XEN_Mouse1.05403841
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.05213483
90* EOMES_21245162_ChIP-Seq_HESCs_Human1.04486675
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04374004
92MYC_18940864_ChIP-ChIP_HL60_Human1.01096664
93FOXP3_21729870_ChIP-Seq_TREG_Human1.00057568
94ETS1_20019798_ChIP-Seq_JURKAT_Human0.98056917
95* NANOG_16153702_ChIP-ChIP_HESCs_Human0.96933913
96* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96829638
97CDX2_20551321_ChIP-Seq_CACO-2_Human0.95301386
98* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94722983
99XRN2_22483619_ChIP-Seq_HELA_Human0.93875184
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93372828
101NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93277489
102KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92070407
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91869513
104* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90932999
105* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87904930
106NCOR1_26117541_ChIP-Seq_K562_Human0.86193507
107MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86026807
108* KAP1_27257070_Chip-Seq_ESCs_Mouse0.83547850
109TP53_22127205_ChIP-Seq_IMR90_Human0.82652843
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81223833
111KDM5A_27292631_Chip-Seq_BREAST_Human0.79915238
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79532423
113GABP_17652178_ChIP-ChIP_JURKAT_Human0.79288336
114AR_21909140_ChIP-Seq_LNCAP_Human0.79233936
115SCL_19346495_ChIP-Seq_HPC-7_Human0.77676567
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77143699
117TTF2_22483619_ChIP-Seq_HELA_Human0.76054304
118YY1_22570637_ChIP-Seq_MALME-3M_Human0.75124175
119ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74915402
120TBX3_20139965_ChIP-Seq_ESCs_Mouse0.73309339
121HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.72660349
122GABP_19822575_ChIP-Seq_HepG2_Human0.72149395
123TBX3_20139965_ChIP-Seq_MESCs_Mouse0.72004523
124EGR1_19374776_ChIP-ChIP_THP-1_Human0.69727272
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.69650344
126TCF7_22412390_ChIP-Seq_EML_Mouse0.69103503
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.68504773
128VDR_23849224_ChIP-Seq_CD4+_Human0.68462660
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.66780477
130HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.65548808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.55948470
2MP0006292_abnormal_olfactory_placode4.54540378
3MP0002254_reproductive_system_inflammat4.43410227
4MP0004264_abnormal_extraembryonic_tissu4.27712771
5MP0008057_abnormal_DNA_replication3.78746407
6MP0004957_abnormal_blastocyst_morpholog3.37316164
7MP0005075_abnormal_melanosome_morpholog3.34261664
8MP0005499_abnormal_olfactory_system3.15814484
9MP0005394_taste/olfaction_phenotype3.15814484
10MP0003941_abnormal_skin_development3.07694763
11MP0003718_maternal_effect3.01432664
12MP0004858_abnormal_nervous_system2.91272786
13MP0002332_abnormal_exercise_endurance2.70433683
14MP0003122_maternal_imprinting2.66795495
15MP0010352_gastrointestinal_tract_polyps2.43734052
16MP0006035_abnormal_mitochondrial_morpho2.39939554
17MP0005257_abnormal_intraocular_pressure2.34898558
18MP0003121_genomic_imprinting2.34256350
19MP0008004_abnormal_stomach_pH2.28986581
20MP0002653_abnormal_ependyma_morphology2.27724892
21MP0003705_abnormal_hypodermis_morpholog2.12436605
22MP0003567_abnormal_fetal_cardiomyocyte2.01608691
23MP0000678_abnormal_parathyroid_gland1.99428248
24MP0000537_abnormal_urethra_morphology1.94111136
25MP0003077_abnormal_cell_cycle1.93992312
26* MP0005380_embryogenesis_phenotype1.86440360
27* MP0001672_abnormal_embryogenesis/_devel1.86440360
28MP0002088_abnormal_embryonic_growth/wei1.82273369
29MP0003938_abnormal_ear_development1.81082571
30MP0003984_embryonic_growth_retardation1.81059422
31MP0003111_abnormal_nucleus_morphology1.76482832
32MP0003123_paternal_imprinting1.76319582
33MP0002277_abnormal_respiratory_mucosa1.75196010
34MP0001293_anophthalmia1.74160712
35MP0000350_abnormal_cell_proliferation1.70840410
36MP0008877_abnormal_DNA_methylation1.66091851
37MP0010094_abnormal_chromosome_stability1.62651266
38MP0002127_abnormal_cardiovascular_syste1.60074915
39MP0010030_abnormal_orbit_morphology1.54023458
40MP0001849_ear_inflammation1.53043949
41MP0001529_abnormal_vocalization1.51660830
42MP0002736_abnormal_nociception_after1.51626064
43MP0004133_heterotaxia1.50993870
44MP0001188_hyperpigmentation1.47238264
45MP0005266_abnormal_metabolism1.46813320
46MP0006054_spinal_hemorrhage1.45966855
47MP0002396_abnormal_hematopoietic_system1.42218332
48MP0009672_abnormal_birth_weight1.40132437
49MP0003183_abnormal_peptide_metabolism1.39633055
50MP0009697_abnormal_copulation1.38813665
51MP0006082_CNS_inflammation1.38398287
52MP0002092_abnormal_eye_morphology1.37982492
53MP0003693_abnormal_embryo_hatching1.36817510
54* MP0002086_abnormal_extraembryonic_tissu1.33928646
55* MP0002085_abnormal_embryonic_tissue1.33724790
56MP0002932_abnormal_joint_morphology1.32274596
57MP0003195_calcinosis1.31652184
58MP0000049_abnormal_middle_ear1.31356359
59MP0000762_abnormal_tongue_morphology1.28949383
60MP0008789_abnormal_olfactory_epithelium1.28584366
61MP0008932_abnormal_embryonic_tissue1.21939812
62MP0000490_abnormal_crypts_of1.18924509
63MP0009840_abnormal_foam_cell1.18671931
64MP0004272_abnormal_basement_membrane1.17148480
65MP0003283_abnormal_digestive_organ1.15671137
66MP0001730_embryonic_growth_arrest1.15670324
67MP0001348_abnormal_lacrimal_gland1.13697932
68MP0003119_abnormal_digestive_system1.12974708
69MP0003315_abnormal_perineum_morphology1.11525094
70MP0002233_abnormal_nose_morphology1.10960369
71MP0004197_abnormal_fetal_growth/weight/1.10742748
72* MP0002084_abnormal_developmental_patter1.10544634
73MP0000313_abnormal_cell_death1.10375935
74MP0008007_abnormal_cellular_replicative1.10111366
75MP0008872_abnormal_physiological_respon1.08411881
76* MP0003890_abnormal_embryonic-extraembry1.07727517
77MP0002114_abnormal_axial_skeleton1.07260057
78MP0002697_abnormal_eye_size1.04506453
79MP0001697_abnormal_embryo_size1.04253290
80MP0002796_impaired_skin_barrier1.03853987
81MP0004043_abnormal_pH_regulation1.03027840
82MP0000462_abnormal_digestive_system1.02574605
83MP0000432_abnormal_head_morphology1.01184200
84MP0003385_abnormal_body_wall1.00876337
85MP0008995_early_reproductive_senescence0.99349168
86MP0000428_abnormal_craniofacial_morphol0.96464264
87MP0002132_abnormal_respiratory_system0.95527960
88* MP0002080_prenatal_lethality0.94714666
89MP0004381_abnormal_hair_follicle0.91333529
90MP0003935_abnormal_craniofacial_develop0.91074518
91MP0003787_abnormal_imprinting0.91066577
92MP0003755_abnormal_palate_morphology0.90766245
93MP0002938_white_spotting0.90345276
94MP0003806_abnormal_nucleotide_metabolis0.90306093
95MP0001984_abnormal_olfaction0.89939023
96MP0008058_abnormal_DNA_repair0.89438241
97MP0000470_abnormal_stomach_morphology0.87588877
98MP0005391_vision/eye_phenotype0.86762532
99MP0005084_abnormal_gallbladder_morpholo0.86400579
100MP0003191_abnormal_cellular_cholesterol0.84387100
101MP0003786_premature_aging0.83668317
102MP0005395_other_phenotype0.83060774
103MP0001177_atelectasis0.82758235
104MP0003137_abnormal_impulse_conducting0.82216792
105MP0002090_abnormal_vision0.81604732
106MP0005248_abnormal_Harderian_gland0.80946997
107MP0008260_abnormal_autophagy0.80484738
108MP0002751_abnormal_autonomic_nervous0.79322018
109MP0000358_abnormal_cell_content/0.78693995
110MP0002925_abnormal_cardiovascular_devel0.78691998
111MP0000750_abnormal_muscle_regeneration0.77574855
112MP0002249_abnormal_larynx_morphology0.75617452
113MP0005023_abnormal_wound_healing0.74868300
114MP0000647_abnormal_sebaceous_gland0.74714380
115MP0002269_muscular_atrophy0.73421741
116MP0002138_abnormal_hepatobiliary_system0.72917817
117MP0001286_abnormal_eye_development0.72512528
118MP0005508_abnormal_skeleton_morphology0.72379159
119MP0005379_endocrine/exocrine_gland_phen0.72245818
120MP0002102_abnormal_ear_morphology0.72228739
121MP0002210_abnormal_sex_determination0.71670586
122MP0009703_decreased_birth_body0.71381976
123MP0000653_abnormal_sex_gland0.69260781
124MP0001145_abnormal_male_reproductive0.67641904
125MP0003136_yellow_coat_color0.67540609
126MP0005187_abnormal_penis_morphology0.67436161
127MP0002116_abnormal_craniofacial_bone0.67271557
128MP0002019_abnormal_tumor_incidence0.66992374
129MP0003861_abnormal_nervous_system0.66975097
130MP0003186_abnormal_redox_activity0.66792847
131* MP0002970_abnormal_white_adipose0.65722104
132MP0006036_abnormal_mitochondrial_physio0.65279228
133MP0004215_abnormal_myocardial_fiber0.65231969
134MP0005384_cellular_phenotype0.64316786
135* MP0008770_decreased_survivor_rate0.63853068
136MP0002163_abnormal_gland_morphology0.63696582
137MP0001915_intracranial_hemorrhage0.63385287
138MP0001119_abnormal_female_reproductive0.61646338
139MP0000639_abnormal_adrenal_gland0.60508615
140MP0003937_abnormal_limbs/digits/tail_de0.60469566
141MP0002111_abnormal_tail_morphology0.59109213
142MP0000749_muscle_degeneration0.58485709
143MP0003448_altered_tumor_morphology0.56253545
144MP0002081_perinatal_lethality0.55774478

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.35737075
2Abdominal situs inversus (HP:0003363)5.55706973
3Abnormality of abdominal situs (HP:0011620)5.55706973
4Multiple enchondromatosis (HP:0005701)5.41172783
5Hepatoblastoma (HP:0002884)5.34001558
6Ependymoma (HP:0002888)4.88251848
7Rib fusion (HP:0000902)4.85222115
8Abnormality of the lower motor neuron (HP:0002366)4.83659442
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.17010153
10Neoplasm of striated muscle (HP:0009728)4.03396892
11* Bilateral microphthalmos (HP:0007633)3.97996503
12Rhabdomyosarcoma (HP:0002859)3.97432075
13Nephroblastoma (Wilms tumor) (HP:0002667)3.92439597
14Abnormal ventriculo-arterial connection (HP:0011563)3.68146430
15Transposition of the great arteries (HP:0001669)3.68146430
16Abnormal connection of the cardiac segments (HP:0011545)3.68146430
17Abnormality of the labia minora (HP:0012880)3.66270542
18Embryonal renal neoplasm (HP:0011794)3.63261260
19Chromsome breakage (HP:0040012)3.62893719
20Testicular atrophy (HP:0000029)3.59110056
21Rectovaginal fistula (HP:0000143)3.57588406
22Rectal fistula (HP:0100590)3.57588406
23Hyperglycinemia (HP:0002154)3.55634405
24Astrocytoma (HP:0009592)3.41865326
25Abnormality of the astrocytes (HP:0100707)3.41865326
26Abnormality of the salivary glands (HP:0010286)3.30589291
27Partial duplication of thumb phalanx (HP:0009944)3.29733277
28Aplasia/hypoplasia of the humerus (HP:0006507)3.19791854
29Intestinal fistula (HP:0100819)3.17360549
30Ragged-red muscle fibers (HP:0003200)3.16530464
31Short humerus (HP:0005792)3.09312378
32Trismus (HP:0000211)3.09292181
33Vaginal fistula (HP:0004320)3.08503092
34Abnormal lung lobation (HP:0002101)3.06850223
35Carpal bone hypoplasia (HP:0001498)3.03713766
36Amyotrophic lateral sclerosis (HP:0007354)3.00449644
37Hyperglycinuria (HP:0003108)2.99940852
38Septo-optic dysplasia (HP:0100842)2.96934048
39Hyperinsulinemic hypoglycemia (HP:0000825)2.95317928
40Reduced antithrombin III activity (HP:0001976)2.95081272
41Absent radius (HP:0003974)2.94096495
42Horizontal nystagmus (HP:0000666)2.93855429
43Bifid tongue (HP:0010297)2.89940635
44Supernumerary spleens (HP:0009799)2.87471467
45Colon cancer (HP:0003003)2.86895288
46Birth length less than 3rd percentile (HP:0003561)2.86339013
47Partial duplication of the phalanx of hand (HP:0009999)2.86097157
48Acute encephalopathy (HP:0006846)2.85815118
49Acute necrotizing encephalopathy (HP:0006965)2.85294502
50Meckel diverticulum (HP:0002245)2.82903627
51Methylmalonic aciduria (HP:0012120)2.79788932
52Abnormal cartilage morphology (HP:0002763)2.79479474
53Anomalous pulmonary venous return (HP:0010772)2.77935110
54Hypochromic anemia (HP:0001931)2.76937382
55Aplasia involving forearm bones (HP:0009822)2.74122332
56Absent forearm bone (HP:0003953)2.74122332
57Abnormality of glycine metabolism (HP:0010895)2.68820589
58Abnormality of serine family amino acid metabolism (HP:0010894)2.68820589
59Preauricular skin tag (HP:0000384)2.67848322
60Abnormality of the ileum (HP:0001549)2.66685547
61Impulsivity (HP:0100710)2.66524686
62Shawl scrotum (HP:0000049)2.65962389
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.65842681
64Abnormal umbilical cord blood vessels (HP:0011403)2.65842527
65Single umbilical artery (HP:0001195)2.65842527
66Abnormality of the fetal cardiovascular system (HP:0010948)2.65842527
67Glioma (HP:0009733)2.58815514
68Reticulocytopenia (HP:0001896)2.57453072
69Pancreatic islet-cell hyperplasia (HP:0004510)2.56918490
70Progressive muscle weakness (HP:0003323)2.55796931
71Horseshoe kidney (HP:0000085)2.47150274
72Abnormal mitochondria in muscle tissue (HP:0008316)2.45475194
73Large earlobe (HP:0009748)2.43366632
74Tongue fasciculations (HP:0001308)2.39757576
75Pendular nystagmus (HP:0012043)2.39559982
76Methylmalonic acidemia (HP:0002912)2.38682752
77Periauricular skin pits (HP:0100277)2.38532805
78Preauricular pit (HP:0004467)2.38532805
79Abnormality of serum amino acid levels (HP:0003112)2.38221306
80Nasolacrimal duct obstruction (HP:0000579)2.38186094
81Medulloblastoma (HP:0002885)2.36900070
82Skin tags (HP:0010609)2.35748200
83Increased CSF lactate (HP:0002490)2.34811423
84Abnormality of pyrimidine metabolism (HP:0004353)2.34693008
85Abnormality of the pulmonary veins (HP:0011718)2.34443693
86Microvesicular hepatic steatosis (HP:0001414)2.31943233
87Abnormality of chromosome segregation (HP:0002916)2.28086521
88Generalized hypotonia (HP:0001290)2.27702866
89Upper motor neuron abnormality (HP:0002127)2.26109897
90Abnormality of the phalanges of the hallux (HP:0010057)2.25441256
91Aplasia/Hypoplasia of the sternum (HP:0006714)2.25302298
92Tetraplegia (HP:0002445)2.23394827
93Type I transferrin isoform profile (HP:0003642)2.23163939
94Glossoptosis (HP:0000162)2.22702824
95Duodenal stenosis (HP:0100867)2.21758317
96Small intestinal stenosis (HP:0012848)2.21758317
97Microretrognathia (HP:0000308)2.19435366
98* Fused cervical vertebrae (HP:0002949)2.18791417
99Sensory axonal neuropathy (HP:0003390)2.17852465
100Malignant neoplasm of the central nervous system (HP:0100836)2.16217556
101Short 5th finger (HP:0009237)2.16033532
102Progressive macrocephaly (HP:0004481)2.14999161
103Abnormality of the musculature of the hand (HP:0001421)2.14874201
104Muscle fibrillation (HP:0010546)2.14389486
105Mitochondrial inheritance (HP:0001427)2.13933737
106Stenosis of the external auditory canal (HP:0000402)2.13158114
1073-Methylglutaconic aciduria (HP:0003535)2.12437798
108Anal stenosis (HP:0002025)2.10988185
109Premature ovarian failure (HP:0008209)2.10853021
110Homocystinuria (HP:0002156)2.10553347
111Abnormality of homocysteine metabolism (HP:0010919)2.10553347
112Abnormality of small intestinal villus morphology (HP:0011472)2.09483095
113Villous atrophy (HP:0011473)2.09483095
114Atrophy/Degeneration involving motor neurons (HP:0007373)2.09166332
115Hyperventilation (HP:0002883)2.07445061
116Abnormality of the preputium (HP:0100587)2.05595116
117Abnormality of the middle phalanges of the toes (HP:0010183)2.04658430
118Increased connective tissue (HP:0009025)2.04033194
119Aplastic anemia (HP:0001915)2.03925476
120Progressive external ophthalmoplegia (HP:0000590)2.03881711
121Abnormality of the septum pellucidum (HP:0007375)2.03565331
122Hypoglycemic seizures (HP:0002173)2.03498314
123Neoplasm of the heart (HP:0100544)2.01589457
124Duplication of thumb phalanx (HP:0009942)2.00928123
125Asplenia (HP:0001746)2.00207662
126Abnormality of the pubic bones (HP:0003172)2.00076095
127Increased hepatocellular lipid droplets (HP:0006565)1.99572359
128Supernumerary nipples (HP:0002558)1.99323772
129Hypopigmentation of the fundus (HP:0007894)1.98422690
130Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97685181
131Pseudobulbar signs (HP:0002200)1.97392377
132Atresia of the external auditory canal (HP:0000413)1.97168809
133Facial cleft (HP:0002006)1.96877990
134Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96719666
135Embryonal neoplasm (HP:0002898)1.96482240
136Upper limb muscle weakness (HP:0003484)1.96382919
137Absent septum pellucidum (HP:0001331)1.96051185
138Cerebral edema (HP:0002181)1.96024065
139Neoplasm of the oral cavity (HP:0100649)1.95948130
140Renal duplication (HP:0000075)1.95720559
141Choanal stenosis (HP:0000452)1.95399595
142Megaloblastic anemia (HP:0001889)1.95058818
143Difficulty running (HP:0009046)1.94842464
144Abnormality of the distal phalanx of the thumb (HP:0009617)1.94282371
145Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.94200571
146Short hallux (HP:0010109)1.94046427
147Neoplasm of the adrenal gland (HP:0100631)1.93932473
148Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93678122
149Abnormality of chromosome stability (HP:0003220)1.93358316
150Missing ribs (HP:0000921)1.93253905
151Angiofibromas (HP:0010615)1.92518084
152Adenoma sebaceum (HP:0009720)1.92518084
153Aplasia/Hypoplasia of the spleen (HP:0010451)1.89909683
154Abnormality of the umbilical cord (HP:0010881)1.89322893
155Abnormality of the vitamin B12 metabolism (HP:0004341)1.89048413
156Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87845943
157Hepatocellular necrosis (HP:0001404)1.87657452
158Increased serum lactate (HP:0002151)1.84350251
159Abnormal number of erythroid precursors (HP:0012131)1.83125557
160Clubbing of toes (HP:0100760)1.82223061
161Cerebral hypomyelination (HP:0006808)1.79790116
162Cerebral palsy (HP:0100021)1.79735751
163Abnormality of methionine metabolism (HP:0010901)1.78877177
164Abnormal protein glycosylation (HP:0012346)1.77425682
165Abnormal glycosylation (HP:0012345)1.77425682
166Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77425682
167Abnormal protein N-linked glycosylation (HP:0012347)1.77425682
168Agnosia (HP:0010524)1.76338222
169Hypoplastic pelvis (HP:0008839)1.76181665
170Absent eyebrow (HP:0002223)1.75989706
171Hypoalphalipoproteinemia (HP:0003233)1.75547245
172Aplasia/Hypoplasia of the hallux (HP:0008362)1.74765107
173Leukodystrophy (HP:0002415)1.72923113
174Abnormality of the clitoris (HP:0000056)1.72909712
175Choanal atresia (HP:0000453)1.72752078
176Abnormality of vitamin B metabolism (HP:0004340)1.71452503
177Increased serum pyruvate (HP:0003542)1.71250451
178Renal agenesis (HP:0000104)1.70788960
179Lactic acidosis (HP:0003128)1.68570426
180Biliary tract neoplasm (HP:0100574)1.67092861
181Lipid accumulation in hepatocytes (HP:0006561)1.66915936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.51179574
2PBK7.24154618
3GRK55.13683830
4ERN14.32697619
5GRK64.07797552
6ADRBK23.08818909
7GRK13.08070083
8VRK23.06906712
9PLK42.93011209
10TTK2.90343558
11CSF1R2.86529553
12MST42.83047513
13MKNK22.64588286
14TGFBR22.64506980
15TYRO32.51751813
16GRK72.45010031
17STK162.42210922
18ZAK2.40282546
19MATK2.40150901
20MAPK72.32769194
21TSSK62.27542516
22LMTK22.25575325
23PLK32.23232511
24STK102.23224074
25EIF2AK32.11542911
26MKNK12.04765027
27MOS2.03640681
28CDK191.92909579
29EIF2AK11.91464794
30CDK71.86975460
31WNK11.81199920
32PDK21.79668401
33EPHA21.74807885
34TRIM281.69767724
35TNIK1.54136509
36NME11.46752783
37PRKG21.42917273
38CAMK41.42160540
39TAF11.41092095
40CHEK21.40936238
41PAK41.40569636
42WNK31.39613647
43OXSR11.36760415
44AKT31.35705482
45PLK11.35627253
46NUAK11.35437171
47NTRK11.32803689
48SMG11.28130843
49WEE11.23238221
50BRSK21.22151276
51TIE11.14397341
52MARK21.10976170
53HIPK21.05666137
54PHKG21.03830627
55PHKG11.03830627
56BUB11.02460064
57ADRBK11.01026529
58CDC71.00120620
59MAP2K40.95927895
60BMPR1B0.94505942
61PLK20.92978613
62MAP3K100.91466082
63FGFR30.89309678
64CHEK10.89192569
65BRSK10.86944672
66EIF2AK20.86006689
67ALK0.85726341
68RPS6KB20.81750068
69AKT20.77082910
70ERBB40.76818942
71NEK20.76046948
72FGFR10.75233486
73MAP2K60.74330399
74MAP3K120.70222322
75CSK0.69058123
76KDR0.66319065
77AURKA0.61084882
78NEK10.57320449
79CDK20.56773420
80MAPK120.56304812
81BRAF0.55673468
82LATS20.54473555
83PRKCI0.53625488
84CSNK1G10.53146566
85SRPK10.52669829
86MTOR0.51859160
87AURKB0.51055497
88MAP3K70.50312664
89DYRK30.49740672
90CDK40.49520312
91ATM0.44950345
92CSNK2A10.44407314
93PASK0.43290681
94MAPKAPK30.42835627
95PAK10.39166460
96TESK20.36753037
97CSNK1E0.35847015
98MAP4K20.35320759
99IKBKB0.33285638
100DYRK20.32643213
101CSNK2A20.32540453
102CDK10.31522722
103IGF1R0.31032333
104MAP3K90.30937147
105PRKCD0.30880832
106DAPK10.30695997
107MELK0.30527052
108TGFBR10.29579149
109ATR0.28789604
110CSNK1G20.28281866
111TAOK20.28187900
112ERBB20.27410872
113MAPK100.27380237
114DMPK0.26556171
115PRKDC0.25861231
116STK30.25428533
117WNK40.24798623
118FGFR20.24436985
119CSNK1G30.23192290
120ILK0.22861517
121PRKCG0.22747825
122PTK20.22068503
123MAPK10.22008411
124PINK10.21563404
125CASK0.21366690
126GSK3B0.21322478
127DAPK30.21291639
128MAPK140.20652946
129CDK80.20286720
130STK390.19768216
131ITK0.19659170
132PRPF4B0.19382663
133NME20.18589716
134CSNK1A10.18523501
135NLK0.18105013
136INSR0.17944608
137MAP3K80.17879847
138INSRR0.17027420
139CDK150.15590916
140CDK11A0.15500332
141MAPK40.15183854
142BMX0.14039214
143STK40.13923247
144PDGFRA0.13896003
145STK380.13762218
146PRKACB0.12895795
147PRKACG0.12649843
148DYRK1A0.12629220
149ACVR1B0.11647730
150CDK180.11617703
151BRD40.11461803
152VRK10.11246135
153GSK3A0.11173703
154RIPK10.10857277
155ICK0.10420995
156PRKD20.10074527
157FLT30.09511085
158PIM10.08829462
159PRKAA10.07908097

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.67878598
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.52437730
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.80897364
4Fructose and mannose metabolism_Homo sapiens_hsa000513.60301394
5Steroid biosynthesis_Homo sapiens_hsa001002.74481686
6DNA replication_Homo sapiens_hsa030302.67108024
7Galactose metabolism_Homo sapiens_hsa000522.48653560
8Arachidonic acid metabolism_Homo sapiens_hsa005902.48344245
9RNA transport_Homo sapiens_hsa030132.39588659
10Mismatch repair_Homo sapiens_hsa034302.36653231
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.29747900
12Ribosome_Homo sapiens_hsa030102.21741909
13Oxidative phosphorylation_Homo sapiens_hsa001902.12971214
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.07080573
15Parkinsons disease_Homo sapiens_hsa050122.03744035
16Fanconi anemia pathway_Homo sapiens_hsa034602.02248475
17One carbon pool by folate_Homo sapiens_hsa006701.96645999
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92866815
19Linoleic acid metabolism_Homo sapiens_hsa005911.92116449
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86154855
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85064707
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82360027
23Homologous recombination_Homo sapiens_hsa034401.80341239
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.79099781
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77362517
26Protein export_Homo sapiens_hsa030601.70926927
27Cell cycle_Homo sapiens_hsa041101.62951740
28Spliceosome_Homo sapiens_hsa030401.62534302
29Vitamin digestion and absorption_Homo sapiens_hsa049771.62263205
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59981546
31Huntingtons disease_Homo sapiens_hsa050161.58972149
32mRNA surveillance pathway_Homo sapiens_hsa030151.55930109
33Pyruvate metabolism_Homo sapiens_hsa006201.54463682
34Propanoate metabolism_Homo sapiens_hsa006401.50713487
35Thyroid cancer_Homo sapiens_hsa052161.48416578
36RNA polymerase_Homo sapiens_hsa030201.47527127
37RNA degradation_Homo sapiens_hsa030181.41903436
38Base excision repair_Homo sapiens_hsa034101.39002998
39mTOR signaling pathway_Homo sapiens_hsa041501.30884148
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24588922
41Fat digestion and absorption_Homo sapiens_hsa049751.19350522
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17143168
43Fatty acid elongation_Homo sapiens_hsa000621.16173055
44Alzheimers disease_Homo sapiens_hsa050101.13181032
45TGF-beta signaling pathway_Homo sapiens_hsa043501.07872745
46Folate biosynthesis_Homo sapiens_hsa007901.06850051
47Other glycan degradation_Homo sapiens_hsa005111.06154447
48p53 signaling pathway_Homo sapiens_hsa041151.03748733
49Nucleotide excision repair_Homo sapiens_hsa034200.99840314
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98966458
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98399092
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96290096
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94956669
54Pyrimidine metabolism_Homo sapiens_hsa002400.94924106
55Basal transcription factors_Homo sapiens_hsa030220.94759046
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90793806
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90674861
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89114903
59Pentose phosphate pathway_Homo sapiens_hsa000300.86760044
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.85014929
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84662584
62Chemical carcinogenesis_Homo sapiens_hsa052040.83473967
63Sulfur relay system_Homo sapiens_hsa041220.83127566
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83099526
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82598854
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78827059
67Arginine and proline metabolism_Homo sapiens_hsa003300.72636036
68Basal cell carcinoma_Homo sapiens_hsa052170.72537607
69N-Glycan biosynthesis_Homo sapiens_hsa005100.71741289
70Non-homologous end-joining_Homo sapiens_hsa034500.70531312
71Oocyte meiosis_Homo sapiens_hsa041140.68634703
72Inositol phosphate metabolism_Homo sapiens_hsa005620.68067305
73Ether lipid metabolism_Homo sapiens_hsa005650.66802885
74Biosynthesis of amino acids_Homo sapiens_hsa012300.66782771
75Starch and sucrose metabolism_Homo sapiens_hsa005000.64443075
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.64016871
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.63994714
78Herpes simplex infection_Homo sapiens_hsa051680.63839238
79Pathways in cancer_Homo sapiens_hsa052000.63547727
80MicroRNAs in cancer_Homo sapiens_hsa052060.63282576
81Cardiac muscle contraction_Homo sapiens_hsa042600.63034732
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62921203
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62254940
84Retinol metabolism_Homo sapiens_hsa008300.62059084
85Ovarian steroidogenesis_Homo sapiens_hsa049130.60479546
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59768256
87Hedgehog signaling pathway_Homo sapiens_hsa043400.55905193
88Acute myeloid leukemia_Homo sapiens_hsa052210.54549480
89Peroxisome_Homo sapiens_hsa041460.54436300
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54158751
91beta-Alanine metabolism_Homo sapiens_hsa004100.53854050
92Carbon metabolism_Homo sapiens_hsa012000.52909994
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52387157
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.51983510
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51968583
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49921441
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.47705522
98Fatty acid metabolism_Homo sapiens_hsa012120.46826998
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44954373
100Proteasome_Homo sapiens_hsa030500.43634653
101Hippo signaling pathway_Homo sapiens_hsa043900.42571020
102Selenocompound metabolism_Homo sapiens_hsa004500.42106566
103Fatty acid degradation_Homo sapiens_hsa000710.41728321
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41014637
105African trypanosomiasis_Homo sapiens_hsa051430.40106448
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40009982
107Choline metabolism in cancer_Homo sapiens_hsa052310.39987967
108Bladder cancer_Homo sapiens_hsa052190.39630450
109Notch signaling pathway_Homo sapiens_hsa043300.38603005
110Butanoate metabolism_Homo sapiens_hsa006500.38121678
111Rap1 signaling pathway_Homo sapiens_hsa040150.37973454
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.37440064
113Arginine biosynthesis_Homo sapiens_hsa002200.37193258
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36526538
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36043156
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34984510
117Apoptosis_Homo sapiens_hsa042100.33718362
118Nitrogen metabolism_Homo sapiens_hsa009100.32675791
119Mineral absorption_Homo sapiens_hsa049780.31269594
120Non-small cell lung cancer_Homo sapiens_hsa052230.29145440
121Tryptophan metabolism_Homo sapiens_hsa003800.29115443
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.28345057
123Regulation of autophagy_Homo sapiens_hsa041400.27923252
124Wnt signaling pathway_Homo sapiens_hsa043100.26684425
125Viral carcinogenesis_Homo sapiens_hsa052030.26544207
126Metabolic pathways_Homo sapiens_hsa011000.26134912
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25300397
128Phototransduction_Homo sapiens_hsa047440.25251527
129HTLV-I infection_Homo sapiens_hsa051660.24430505
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24395797
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23240563
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21642007
133AMPK signaling pathway_Homo sapiens_hsa041520.21470071
134Purine metabolism_Homo sapiens_hsa002300.20894530
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18713131
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17555253
137Renin-angiotensin system_Homo sapiens_hsa046140.15269630
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.14546137
139Glutathione metabolism_Homo sapiens_hsa004800.14363133
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13900158
141Tight junction_Homo sapiens_hsa045300.13733230
142Proteoglycans in cancer_Homo sapiens_hsa052050.13011153
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12505601
144Colorectal cancer_Homo sapiens_hsa052100.12270302
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11464986

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