GDF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)7.55906558
2sequestering of extracellular ligand from receptor (GO:0035581)7.53559084
3keratan sulfate catabolic process (GO:0042340)7.12291463
4prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.81266682
5type B pancreatic cell proliferation (GO:0044342)6.31874618
6regulation of skeletal muscle contraction (GO:0014819)5.29297892
7branching involved in prostate gland morphogenesis (GO:0060442)5.29010191
8lateral sprouting from an epithelium (GO:0060601)5.10454759
9xenobiotic catabolic process (GO:0042178)4.89027639
10endodermal cell differentiation (GO:0035987)4.86313814
11extracellular negative regulation of signal transduction (GO:1900116)4.79176650
12extracellular regulation of signal transduction (GO:1900115)4.79176650
13metanephric mesenchyme development (GO:0072075)4.78908055
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.73465767
15protein deneddylation (GO:0000338)4.60169272
16protein heterotrimerization (GO:0070208)4.60022445
17extracellular fibril organization (GO:0043206)4.56850196
18lung-associated mesenchyme development (GO:0060484)4.53607920
19cullin deneddylation (GO:0010388)4.42828163
20cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.40814117
21collagen fibril organization (GO:0030199)4.30094191
22kidney mesenchyme development (GO:0072074)4.25465284
23dermatan sulfate biosynthetic process (GO:0030208)4.25238768
24negative regulation of smooth muscle cell migration (GO:0014912)4.17578035
25regulation of transforming growth factor beta2 production (GO:0032909)4.17546251
26outer ear morphogenesis (GO:0042473)4.10265471
27negative regulation of leukocyte chemotaxis (GO:0002689)4.06607472
28actin-myosin filament sliding (GO:0033275)3.98425851
29muscle filament sliding (GO:0030049)3.98425851
30negative regulation of cartilage development (GO:0061037)3.95764305
31cellular response to vitamin (GO:0071295)3.95712763
32endothelial cell morphogenesis (GO:0001886)3.92590185
33dermatan sulfate metabolic process (GO:0030205)3.89356190
34mesenchymal-epithelial cell signaling (GO:0060638)3.87005710
35chondrocyte development (GO:0002063)3.86780812
36keratan sulfate biosynthetic process (GO:0018146)3.85895216
37planar cell polarity pathway involved in neural tube closure (GO:0090179)3.85206606
38negative regulation of chondrocyte differentiation (GO:0032331)3.78811834
39bone trabecula formation (GO:0060346)3.76337686
40regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.76284980
41fibril organization (GO:0097435)3.75066052
42glomerulus development (GO:0032835)3.68208268
43heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.62634896
44myoblast migration (GO:0051451)3.60640596
45skeletal muscle tissue regeneration (GO:0043403)3.60267834
46regulation of cardioblast proliferation (GO:0003264)3.53768045
47regulation of secondary heart field cardioblast proliferation (GO:0003266)3.53768045
48embryonic skeletal joint morphogenesis (GO:0060272)3.53044762
49axon extension involved in axon guidance (GO:0048846)3.52667047
50neuron projection extension involved in neuron projection guidance (GO:1902284)3.52667047
51nephron epithelium morphogenesis (GO:0072088)3.52546522
52nephron tubule morphogenesis (GO:0072078)3.52546522
53white fat cell differentiation (GO:0050872)3.51666816
54peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.50340866
55response to nitrosative stress (GO:0051409)3.50045714
56muscle cell migration (GO:0014812)3.44707169
57actin-mediated cell contraction (GO:0070252)3.44214228
58regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44111139
59negative regulation of fatty acid transport (GO:2000192)3.43834564
60branch elongation of an epithelium (GO:0060602)3.42146809
61renal filtration (GO:0097205)3.41574951
62embryonic cranial skeleton morphogenesis (GO:0048701)3.39421567
63muscle cell fate commitment (GO:0042693)3.39131528
64extracellular matrix assembly (GO:0085029)3.39123925
65negative regulation of nitric-oxide synthase activity (GO:0051001)3.32391355
66adhesion of symbiont to host cell (GO:0044650)3.31526713
67virion attachment to host cell (GO:0019062)3.31526713
68proximal/distal pattern formation (GO:0009954)3.30110045
69male genitalia development (GO:0030539)3.28926842
70non-canonical Wnt signaling pathway (GO:0035567)3.28736566
71epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.26712149
72NADH metabolic process (GO:0006734)3.24465474
73heparin metabolic process (GO:0030202)3.23680563
74heparin biosynthetic process (GO:0030210)3.23680563
75cell migration involved in heart development (GO:0060973)3.22969257
76negative regulation of JAK-STAT cascade (GO:0046426)3.21298231
77glomerular filtration (GO:0003094)3.20726001
78cochlea morphogenesis (GO:0090103)3.20066480
79middle ear morphogenesis (GO:0042474)3.19457927
80chaperone-mediated protein transport (GO:0072321)3.16058232
81wound healing, spreading of epidermal cells (GO:0035313)3.15814042
82negative regulation of nitric oxide biosynthetic process (GO:0045019)3.15432456
83endocardial cushion morphogenesis (GO:0003203)3.13950789
84regulation of sequestering of triglyceride (GO:0010889)3.13838241
85positive regulation of fatty acid oxidation (GO:0046321)3.12847165
86smooth muscle tissue development (GO:0048745)3.12461273
87negative regulation of BMP signaling pathway (GO:0030514)3.11746141
88positive regulation of mitochondrial fission (GO:0090141)3.11255383
89axis elongation (GO:0003401)3.11098029
90prostate gland epithelium morphogenesis (GO:0060740)3.11034183
91pattern specification involved in kidney development (GO:0061004)3.09347249
92keratan sulfate metabolic process (GO:0042339)3.08245853
93skeletal muscle fiber development (GO:0048741)3.08223309
94protein maturation by protein folding (GO:0022417)3.06974668
95response to redox state (GO:0051775)3.06837397
96detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.05697692
97blood vessel maturation (GO:0001955)3.05121742
98morphogenesis of an epithelial fold (GO:0060571)3.05010577
99cell migration involved in sprouting angiogenesis (GO:0002042)3.04142846
100renal tubule morphogenesis (GO:0061333)3.03849919
101positive regulation of SMAD protein import into nucleus (GO:0060391)3.02969990
102cranial suture morphogenesis (GO:0060363)3.01313822
103* regulation of cartilage development (GO:0061035)3.00127697
104cell proliferation involved in metanephros development (GO:0072203)2.99681343
105organ induction (GO:0001759)2.99355037
106negative regulation of axon guidance (GO:1902668)2.99011596
107regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.98980451
108multicellular organismal metabolic process (GO:0044236)2.97850867
109body morphogenesis (GO:0010171)2.97728842
110regulation of heart morphogenesis (GO:2000826)2.97528717
111mesenchyme morphogenesis (GO:0072132)2.96759449
112skin morphogenesis (GO:0043589)2.96334785
113positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.95554099
114chondrocyte proliferation (GO:0035988)2.94332447
115mesenchymal cell differentiation involved in kidney development (GO:0072161)2.93613139
116mesenchymal cell differentiation involved in renal system development (GO:2001012)2.93613139
117mesenchymal cell proliferation (GO:0010463)2.92326191
118positive regulation of fatty acid beta-oxidation (GO:0032000)2.90833890
119negative regulation of axon extension involved in axon guidance (GO:0048843)2.89034848
120polarized epithelial cell differentiation (GO:0030859)2.88769872
121substrate-dependent cell migration (GO:0006929)2.88184743
122tooth mineralization (GO:0034505)2.87192144
123* positive regulation of cartilage development (GO:0061036)2.86371649
124cellular response to vitamin D (GO:0071305)2.85907254
125protein localization to cell surface (GO:0034394)2.85201984
126negative regulation of cardiac muscle tissue growth (GO:0055022)2.83348541
127negative regulation of heart growth (GO:0061117)2.83348541
128proteasome assembly (GO:0043248)2.82276848
129multicellular organismal catabolic process (GO:0044243)2.81790596
130Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.81747601
131camera-type eye morphogenesis (GO:0048593)2.80242916
132iron ion import (GO:0097286)2.79748106
133skeletal muscle contraction (GO:0003009)2.79124688
134regulation of SMAD protein import into nucleus (GO:0060390)2.78656097
135negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.78473857
136positive regulation of endothelial cell apoptotic process (GO:2000353)2.77030345
137embryonic digit morphogenesis (GO:0042733)2.76275415
138establishment of tissue polarity (GO:0007164)2.76048050
139establishment of planar polarity (GO:0001736)2.76048050
140negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.75828961
141retina vasculature morphogenesis in camera-type eye (GO:0061299)2.75702990
142regulation of mesenchymal cell proliferation (GO:0010464)2.75430265
143cell adhesion mediated by integrin (GO:0033627)2.74997513
144regulation of integrin-mediated signaling pathway (GO:2001044)2.74328307
145neural crest cell development (GO:0014032)2.72330628
146positive regulation of mesenchymal cell proliferation (GO:0002053)2.72206899
147regulation of axon extension involved in axon guidance (GO:0048841)2.71977828
148actin filament-based movement (GO:0030048)2.71393903
149collagen metabolic process (GO:0032963)2.70606878
150craniofacial suture morphogenesis (GO:0097094)2.69747169
151multicellular organismal macromolecule metabolic process (GO:0044259)2.69169751
152actin filament depolymerization (GO:0030042)2.68325176
153* extracellular matrix organization (GO:0030198)2.67294123
154wound healing, spreading of cells (GO:0044319)2.67245616
155glomerular basement membrane development (GO:0032836)2.66943943
156* extracellular structure organization (GO:0043062)2.66678465
157negative chemotaxis (GO:0050919)2.65243792
158protein retention in ER lumen (GO:0006621)2.64372302
159collagen catabolic process (GO:0030574)2.64301826
160embryonic forelimb morphogenesis (GO:0035115)2.64259998
161peptidyl-proline hydroxylation (GO:0019511)2.64183757
162one-carbon compound transport (GO:0019755)2.63868597
163extracellular matrix disassembly (GO:0022617)2.62703151
164cellular response to amino acid stimulus (GO:0071230)2.62509550
165cartilage morphogenesis (GO:0060536)2.62318136
166regulation of chemokine-mediated signaling pathway (GO:0070099)2.62090144
167regulation of organ formation (GO:0003156)2.62078973
168regulation of establishment of planar polarity (GO:0090175)2.61231186
169COPII vesicle coating (GO:0048208)2.61147773
170negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.61072814
171regulation of fatty acid oxidation (GO:0046320)2.60713977
172negative regulation of catenin import into nucleus (GO:0035414)2.60375310
173regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.60016609
174sulfur compound catabolic process (GO:0044273)2.59522982
175positive regulation of protein kinase C signaling (GO:0090037)2.57842485
176endocardial cushion development (GO:0003197)2.55025174
177endothelial cell proliferation (GO:0001935)2.54181424
178maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.53852822
179regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.51900028
180mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.50220580
181negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.49795496
182proteoglycan biosynthetic process (GO:0030166)2.49733294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.34742588
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.32402757
3CLOCK_20551151_ChIP-Seq_293T_Human4.28825350
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.77240743
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.94239827
6ZNF263_19887448_ChIP-Seq_K562_Human2.64361741
7GBX2_23144817_ChIP-Seq_PC3_Human2.61989055
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61481053
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61039989
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.41505760
11ZNF274_21170338_ChIP-Seq_K562_Hela2.38388986
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.31908602
13TP53_20018659_ChIP-ChIP_R1E_Mouse2.21522005
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17949893
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17949893
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.12365535
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.10456365
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09380161
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07594663
20NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.06096179
21NRF2_20460467_ChIP-Seq_MEFs_Mouse2.06096179
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.06059744
23* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.03219592
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01719201
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00801722
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00379155
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.93501410
28FUS_26573619_Chip-Seq_HEK293_Human1.93069425
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.91974580
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.91566149
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87509833
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85996502
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85199385
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83713957
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.82556597
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.81521877
37* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78380455
38* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77690114
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76255239
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74013753
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73392675
42TP53_16413492_ChIP-PET_HCT116_Human1.70835954
43P300_19829295_ChIP-Seq_ESCs_Human1.70831371
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70364912
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69783390
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69508721
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.68966714
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.66461095
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.66396976
50TAF15_26573619_Chip-Seq_HEK293_Human1.65933064
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65714737
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65512849
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63226404
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61566351
55AR_21572438_ChIP-Seq_LNCaP_Human1.60827215
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.58267234
57EWS_26573619_Chip-Seq_HEK293_Human1.57729263
58RACK7_27058665_Chip-Seq_MCF-7_Human1.56378384
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.56029062
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.55930341
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55916902
62SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.54595178
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54006979
64AR_21909140_ChIP-Seq_LNCAP_Human1.53373072
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53236927
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52220343
67ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50540763
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.50269737
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48955222
70* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48597515
71IGF1R_20145208_ChIP-Seq_DFB_Human1.45449609
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44707485
73CJUN_26792858_Chip-Seq_BT549_Human1.44208923
74MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.43362730
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42550966
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42153961
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42048434
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41039248
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40700344
80SA1_22415368_ChIP-Seq_MEFs_Mouse1.38035029
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37783059
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37211688
83* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36443973
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.35655319
85* ELK3_25401928_ChIP-Seq_HUVEC_Human1.34291835
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31864705
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.31280318
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30802333
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30507764
90SMC1_22415368_ChIP-Seq_MEFs_Mouse1.30493093
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30306803
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.27460859
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.26609099
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22449472
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.19383677
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19140501
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18744505
98* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18471166
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18418763
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18263832
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18111378
102TP53_22127205_ChIP-Seq_IMR90_Human1.17945253
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.17538350
104PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.17467135
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17451132
106SMAD4_21799915_ChIP-Seq_A2780_Human1.16953926
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16023050
108KDM2B_26808549_Chip-Seq_K562_Human1.15228733
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.14951764
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14873218
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.13150386
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12943845
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10920700
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10668046
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09811072
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.09371876
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09267203
118ELK1_22589737_ChIP-Seq_MCF10A_Human1.09133712
119* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08397463
120JUN_21703547_ChIP-Seq_K562_Human1.07918842
121PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07858542
122AR_25329375_ChIP-Seq_VCAP_Human1.07149762
123BRD4_25478319_ChIP-Seq_HGPS_Human1.05854960
124* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05819789
125TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05753371
126TP53_18474530_ChIP-ChIP_U2OS_Human1.04181783
127CREB1_26743006_Chip-Seq_LNCaP_Human1.03844895
128RNF2_27304074_Chip-Seq_NSC_Mouse1.02906184
129RUNX1_27514584_Chip-Seq_MCF-7_Human1.02652494
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02610484
131NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00572970
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.99644372
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.99617496
134NANOG_18555785_Chip-Seq_ESCs_Mouse0.97997194
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96759723
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96751758
137KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96645367
138TBX20_22328084_ChIP-Seq_HEART_Mouse0.96482920
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.96482920
140NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95783650
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95267508
142* EZH2_27294783_Chip-Seq_ESCs_Mouse0.95006898
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94940408
144LXR_22292898_ChIP-Seq_THP-1_Human0.94735764
145PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94378416
146TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94206210
147TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94001256
148BCAT_22108803_ChIP-Seq_LS180_Human0.93961350
149ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93728809
150SOX2_19829295_ChIP-Seq_ESCs_Human0.93527566
151NANOG_19829295_ChIP-Seq_ESCs_Human0.93527566
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93396764
153SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92913733
154EST1_17652178_ChIP-ChIP_JURKAT_Human0.92047075
155ELK1_19687146_ChIP-ChIP_HELA_Human0.91847612
156CRX_20693478_ChIP-Seq_RETINA_Mouse0.91647904
157TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91404516
158FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90434478
159KDM2B_26808549_Chip-Seq_JURKAT_Human0.90242505
160* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90035914
161SOX2_20726797_ChIP-Seq_SW620_Human0.89918857
162* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89882837
163RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89846210
164SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89822041
165NFE2_27457419_Chip-Seq_LIVER_Mouse0.88873650
166* SOX9_26525672_Chip-Seq_HEART_Mouse0.88614130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.66263947
2MP0009053_abnormal_anal_canal5.52088610
3MP0010030_abnormal_orbit_morphology4.55232345
4MP0001958_emphysema4.03702463
5MP0005275_abnormal_skin_tensile3.45377875
6MP0000537_abnormal_urethra_morphology3.30286950
7MP0006054_spinal_hemorrhage3.12581378
8MP0005187_abnormal_penis_morphology3.05814496
9MP0005257_abnormal_intraocular_pressure3.04097272
10MP0009250_abnormal_appendicular_skeleto2.79535880
11MP0010386_abnormal_urinary_bladder2.75033329
12MP0008438_abnormal_cutaneous_collagen2.50205698
13MP0003950_abnormal_plasma_membrane2.40979594
14MP0002108_abnormal_muscle_morphology2.38237963
15MP0001542_abnormal_bone_strength2.22811145
16MP0000751_myopathy2.20645374
17MP0000013_abnormal_adipose_tissue2.20236003
18MP0005508_abnormal_skeleton_morphology2.19541600
19MP0008789_abnormal_olfactory_epithelium2.09981777
20MP0003705_abnormal_hypodermis_morpholog2.06120017
21MP0001849_ear_inflammation2.05028756
22MP0004134_abnormal_chest_morphology2.00771713
23MP0000733_abnormal_muscle_development2.00363124
24MP0002877_abnormal_melanocyte_morpholog1.97636705
25MP0004272_abnormal_basement_membrane1.95764244
26MP0000747_muscle_weakness1.95536995
27MP0000762_abnormal_tongue_morphology1.89594649
28MP0005171_absent_coat_pigmentation1.88404587
29* MP0003937_abnormal_limbs/digits/tail_de1.88265825
30MP0003385_abnormal_body_wall1.87353221
31MP0003942_abnormal_urinary_system1.83378403
32MP0004185_abnormal_adipocyte_glucose1.83286357
33MP0000566_synostosis1.77594254
34MP0003566_abnormal_cell_adhesion1.69061637
35MP0002282_abnormal_trachea_morphology1.68063742
36MP0000534_abnormal_ureter_morphology1.65470541
37* MP0002932_abnormal_joint_morphology1.63133812
38MP0003123_paternal_imprinting1.61614592
39* MP0002115_abnormal_skeleton_extremities1.60282525
40MP0002233_abnormal_nose_morphology1.60105222
41MP0003315_abnormal_perineum_morphology1.51096784
42MP0004145_abnormal_muscle_electrophysio1.50967034
43MP0000759_abnormal_skeletal_muscle1.50699757
44MP0002933_joint_inflammation1.50290538
45MP0004087_abnormal_muscle_fiber1.48843314
46MP0003646_muscle_fatigue1.48146981
47MP0003279_aneurysm1.47569358
48* MP0000163_abnormal_cartilage_morphology1.47253940
49MP0002249_abnormal_larynx_morphology1.45371338
50MP0001243_abnormal_dermal_layer1.44776835
51MP0000049_abnormal_middle_ear1.44521661
52MP0001348_abnormal_lacrimal_gland1.44226112
53MP0005666_abnormal_adipose_tissue1.43751557
54MP0000003_abnormal_adipose_tissue1.42692916
55MP0004130_abnormal_muscle_cell1.40168470
56MP0001299_abnormal_eye_distance/1.39929297
57MP0000428_abnormal_craniofacial_morphol1.37190031
58MP0005369_muscle_phenotype1.34651493
59MP0004233_abnormal_muscle_weight1.31921154
60MP0005375_adipose_tissue_phenotype1.29286939
61MP0002938_white_spotting1.28091675
62* MP0002109_abnormal_limb_morphology1.24519446
63MP0005499_abnormal_olfactory_system1.24473316
64MP0005394_taste/olfaction_phenotype1.24473316
65MP0003755_abnormal_palate_morphology1.24129207
66MP0000750_abnormal_muscle_regeneration1.23001520
67MP0005084_abnormal_gallbladder_morpholo1.20581052
68MP0001346_abnormal_lacrimal_gland1.19203239
69MP0004858_abnormal_nervous_system1.14232589
70MP0010368_abnormal_lymphatic_system1.12470950
71MP0003938_abnormal_ear_development1.12353470
72MP0002090_abnormal_vision1.12215586
73MP0005390_skeleton_phenotype1.12203039
74MP0005670_abnormal_white_adipose1.09988918
75MP0009384_cardiac_valve_regurgitation1.07550769
76MP0000678_abnormal_parathyroid_gland1.04858075
77MP0005197_abnormal_uvea_morphology1.04492302
78MP0002106_abnormal_muscle_physiology1.02546493
79MP0001879_abnormal_lymphatic_vessel1.00666687
80* MP0002113_abnormal_skeleton_development0.99822382
81MP0002896_abnormal_bone_mineralization0.99210180
82MP0000647_abnormal_sebaceous_gland0.99078960
83MP0006072_abnormal_retinal_apoptosis0.97625332
84MP0005595_abnormal_vascular_smooth0.97270674
85MP0002234_abnormal_pharynx_morphology0.96633901
86MP0002060_abnormal_skin_morphology0.95568877
87MP0002116_abnormal_craniofacial_bone0.94348339
88* MP0002114_abnormal_axial_skeleton0.93325752
89MP0003091_abnormal_cell_migration0.92736207
90MP0001270_distended_abdomen0.92508201
91MP0005620_abnormal_muscle_contractility0.92472362
92MP0002971_abnormal_brown_adipose0.92465788
93MP0005248_abnormal_Harderian_gland0.91642685
94MP0002168_other_aberrant_phenotype0.89522797
95MP0005623_abnormal_meninges_morphology0.89479849
96MP0010630_abnormal_cardiac_muscle0.86209817
97MP0000749_muscle_degeneration0.84220021
98MP0003941_abnormal_skin_development0.82726542
99MP0000569_abnormal_digit_pigmentation0.80694258
100MP0003935_abnormal_craniofacial_develop0.80387373
101MP0000462_abnormal_digestive_system0.80340276
102MP0000538_abnormal_urinary_bladder0.78430866
103MP0004885_abnormal_endolymph0.78393997
104MP0002295_abnormal_pulmonary_circulatio0.76612151
105MP0009840_abnormal_foam_cell0.76000595
106MP0004036_abnormal_muscle_relaxation0.75084550
107MP0000579_abnormal_nail_morphology0.74473864
108MP0002837_dystrophic_cardiac_calcinosis0.74033873
109MP0001529_abnormal_vocalization0.73750763
110MP0000767_abnormal_smooth_muscle0.73003964
111MP0004147_increased_porphyrin_level0.71443673
112MP0002102_abnormal_ear_morphology0.71202640
113MP0005023_abnormal_wound_healing0.70106676
114MP0002111_abnormal_tail_morphology0.70034242
115MP0009780_abnormal_chondrocyte_physiolo0.69515880
116MP0000516_abnormal_urinary_system0.67868550
117MP0005367_renal/urinary_system_phenotyp0.67868550
118MP0000427_abnormal_hair_cycle0.67864481
119MP0003115_abnormal_respiratory_system0.67470250
120MP0000613_abnormal_salivary_gland0.67072560
121MP0002177_abnormal_outer_ear0.66086543
122MP0003283_abnormal_digestive_organ0.64127688
123MP0004133_heterotaxia0.63491551
124MP0002092_abnormal_eye_morphology0.62653055
125MP0005193_abnormal_anterior_eye0.62631945
126MP0002128_abnormal_blood_circulation0.62377635
127MP0000015_abnormal_ear_pigmentation0.62287807
128MP0005388_respiratory_system_phenotype0.61647321
129MP0002133_abnormal_respiratory_system0.61647321
130MP0003119_abnormal_digestive_system0.60382763
131MP0003122_maternal_imprinting0.59937159
132MP0001756_abnormal_urination0.59225269
133MP0002160_abnormal_reproductive_system0.58750373
134MP0000432_abnormal_head_morphology0.58700673
135MP0003567_abnormal_fetal_cardiomyocyte0.58523639
136MP0000467_abnormal_esophagus_morphology0.57804654
137MP0005076_abnormal_cell_differentiation0.56548857
138MP0001614_abnormal_blood_vessel0.56088188
139MP0002254_reproductive_system_inflammat0.55683171
140MP0000372_irregular_coat_pigmentation0.54397531
141MP0008775_abnormal_heart_ventricle0.53299999
142MP0003186_abnormal_redox_activity0.52662850
143MP0003195_calcinosis0.48858024
144MP0002876_abnormal_thyroid_physiology0.46934942
145MP0006276_abnormal_autonomic_nervous0.45249987
146MP0001293_anophthalmia0.43797390
147MP0005165_increased_susceptibility_to0.43490450

Predicted human phenotypes

RankGene SetZ-score
1Aortic dissection (HP:0002647)5.58217791
2Absent phalangeal crease (HP:0006109)5.15409085
3Type 1 muscle fiber predominance (HP:0003803)4.90150687
4Soft skin (HP:0000977)4.76434845
5Aortic aneurysm (HP:0004942)4.74524254
6Abnormality of dentin (HP:0010299)4.59129484
7Short middle phalanx of the 5th finger (HP:0004220)4.53403144
8Abnormality of the 4th metacarpal (HP:0010012)4.21007971
9Abnormal finger flexion creases (HP:0006143)4.19768886
10Cervical subluxation (HP:0003308)3.95847187
11Mitral stenosis (HP:0001718)3.93269840
12Vascular tortuosity (HP:0004948)3.89725991
13Abnormality of the distal phalanges of the toes (HP:0010182)3.88093051
14Bladder diverticulum (HP:0000015)3.86047988
15Genu recurvatum (HP:0002816)3.84589494
16Ulnar deviation of the wrist (HP:0003049)3.76422762
17* Abnormality of the middle phalanges of the toes (HP:0010183)3.76267156
18* Mesomelia (HP:0003027)3.73779623
19Broad distal phalanx of finger (HP:0009836)3.68544712
20Nemaline bodies (HP:0003798)3.62274160
21Spondylolisthesis (HP:0003302)3.55258160
22Protrusio acetabuli (HP:0003179)3.54466767
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.49635155
24Short 5th finger (HP:0009237)3.48337334
25Atrophic scars (HP:0001075)3.43536742
26Arterial tortuosity (HP:0005116)3.39570433
27Muscle fiber inclusion bodies (HP:0100299)3.38933634
28Aortic regurgitation (HP:0001659)3.36566035
29* Deformed tarsal bones (HP:0008119)3.32221606
30Calcaneovalgus deformity (HP:0001848)3.32221606
31Premature rupture of membranes (HP:0001788)3.30895986
32Hypoplastic ischia (HP:0003175)3.30037169
33Shallow orbits (HP:0000586)3.22112418
34Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.16991410
35Round ear (HP:0100830)3.15627838
36Wormian bones (HP:0002645)3.12808139
37* Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.11875749
38* Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.09974633
39Cardiovascular calcification (HP:0011915)3.09403731
40Increased corneal curvature (HP:0100692)3.08029967
41Keratoconus (HP:0000563)3.08029967
42Vertebral compression fractures (HP:0002953)3.05570092
43Epiphyseal dysplasia (HP:0002656)3.04316527
44Distal arthrogryposis (HP:0005684)3.01503191
45Peritonitis (HP:0002586)3.01234108
46Blue sclerae (HP:0000592)2.97063043
47Fragile skin (HP:0001030)2.96774292
48Exercise-induced myalgia (HP:0003738)2.95334550
49Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.92460917
50Aortic valve stenosis (HP:0001650)2.90437780
51Dilatation of the ascending aorta (HP:0005111)2.87374562
52Abnormal tarsal ossification (HP:0008369)2.87179821
53Hypoventilation (HP:0002791)2.84948519
54Increased connective tissue (HP:0009025)2.81908583
55* Abnormality of the phalanges of the 5th finger (HP:0004213)2.79058351
56Abnormality of the ischium (HP:0003174)2.78948501
57* Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.78066258
58Bowel diverticulosis (HP:0005222)2.74920258
59Joint stiffness (HP:0001387)2.74191643
60Slender build (HP:0001533)2.73402912
61Abnormality of the phalanges of the hallux (HP:0010057)2.72987939
62* Deviation of the hallux (HP:0010051)2.70264176
63Syringomyelia (HP:0003396)2.69140739
64Spinal cord lesions (HP:0100561)2.69140739
65* Short middle phalanx of finger (HP:0005819)2.66609749
66Delayed gross motor development (HP:0002194)2.66412268
67* Abnormality of the 2nd finger (HP:0004100)2.66336667
68* Tarsal synostosis (HP:0008368)2.65492560
69Abnormality of the calcaneus (HP:0008364)2.64340219
70Joint laxity (HP:0001388)2.62586806
71Abnormality of skeletal muscle fiber size (HP:0012084)2.61553873
72Overgrowth (HP:0001548)2.61212576
73Increased variability in muscle fiber diameter (HP:0003557)2.60029385
74Hyperextensible skin (HP:0000974)2.59555222
75Broad thumb (HP:0011304)2.55592093
76Ankle contracture (HP:0006466)2.54210177
77* Carpal synostosis (HP:0009702)2.53553184
78Abnormality of the distal phalanx of the thumb (HP:0009617)2.52297738
79Mitral valve prolapse (HP:0001634)2.51349398
80Spinal rigidity (HP:0003306)2.49671210
81Bifid scrotum (HP:0000048)2.48185023
82Muscle fiber splitting (HP:0003555)2.47317901
83Small epiphyses (HP:0010585)2.45156849
84* Short hallux (HP:0010109)2.44595244
85Biconcave vertebral bodies (HP:0004586)2.41962921
86Broad metatarsal (HP:0001783)2.40054966
87Abnormal delivery (HP:0001787)2.39254036
88Mildly elevated creatine phosphokinase (HP:0008180)2.37701415
89* Synostosis of carpal bones (HP:0005048)2.36211509
90* Synostosis involving bones of the feet (HP:0009140)2.36183167
91* Synostosis involving bones of the lower limbs (HP:0009138)2.36183167
92Ureteral stenosis (HP:0000071)2.35710539
93Irregular epiphyses (HP:0010582)2.32355086
94Mitral regurgitation (HP:0001653)2.32251546
95* Symphalangism affecting the phalanges of the hand (HP:0009773)2.32184234
96Bell-shaped thorax (HP:0001591)2.31560982
97Flat capital femoral epiphysis (HP:0003370)2.30136902
98* Hallux valgus (HP:0001822)2.26922061
99* Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.26100355
100Wrist flexion contracture (HP:0001239)2.24674744
101Abnormal foot bone ossification (HP:0010675)2.24510814
102* Ulnar deviation of finger (HP:0009465)2.23808122
103Abnormality of the acetabulum (HP:0003170)2.23780064
104Short nail (HP:0001799)2.21998794
105Broad long bones (HP:0005622)2.21978618
106Striae distensae (HP:0001065)2.20515589
107Ovoid vertebral bodies (HP:0003300)2.20148384
108* Aplasia/Hypoplasia of the hallux (HP:0008362)2.18372068
109* Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.15668904
110* Short 1st metacarpal (HP:0010034)2.15668904
111Broad phalanx (HP:0006009)2.14842383
112Pulmonary artery stenosis (HP:0004415)2.13947759
113Abnormality of the fetal cardiovascular system (HP:0010948)2.12871427
114Abnormal umbilical cord blood vessels (HP:0011403)2.12871427
115Single umbilical artery (HP:0001195)2.12871427
116Abnormality of carpal bone ossification (HP:0006257)2.11724225
117* Abnormality of the middle phalanges of the hand (HP:0009833)2.11563013
118* Short metatarsal (HP:0010743)2.10795530
119Myopathic facies (HP:0002058)2.10080425
120Generalized amyotrophy (HP:0003700)2.08050686
121Protruding ear (HP:0000411)2.07456141
122Broad phalanges of the hand (HP:0009768)2.07437986
123* Synostosis involving bones of the hand (HP:0004278)2.07258473
124Limb-girdle muscle weakness (HP:0003325)2.06398942
125Delayed CNS myelination (HP:0002188)2.06226641
126Neonatal short-limb short stature (HP:0008921)2.05605219
127Elbow flexion contracture (HP:0002987)2.05225030
128* Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.04984201
129Exostoses (HP:0100777)2.04758276
130Exercise-induced muscle cramps (HP:0003710)2.04499147
131Rectal prolapse (HP:0002035)2.04441030
132Abnormality of the anterior chamber (HP:0000593)2.04089736
133Broad ribs (HP:0000885)2.03890284
134Follicular hyperkeratosis (HP:0007502)2.03650290
135Ureteral obstruction (HP:0006000)2.03580508
136Mild short stature (HP:0003502)2.02817388
137Ectopia lentis (HP:0001083)2.02726297
138Nephronophthisis (HP:0000090)2.01691780
139Ulnar bowing (HP:0003031)2.01501291
140Short clavicles (HP:0000894)2.00378732
141Cupped ribs (HP:0000887)1.99630090
142Cutaneous finger syndactyly (HP:0010554)1.98441224
143Broad finger (HP:0001500)1.98391416
144Renal duplication (HP:0000075)1.97458183
145Infantile muscular hypotonia (HP:0008947)1.97438626
146Abnormality of the umbilical cord (HP:0010881)1.97142385
147Myoglobinuria (HP:0002913)1.95823373
148Delayed epiphyseal ossification (HP:0002663)1.92191075
149Flat acetabular roof (HP:0003180)1.91783966
150* Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.91284992
151Wide anterior fontanel (HP:0000260)1.90019209
152Bradycardia (HP:0001662)1.89866867
153Osteoarthritis (HP:0002758)1.89029947
154Shoulder girdle muscle weakness (HP:0003547)1.88381173
155Coronal craniosynostosis (HP:0004440)1.86764314
156Breech presentation (HP:0001623)1.86605200
157Stage 5 chronic kidney disease (HP:0003774)1.82583536
158Flat cornea (HP:0007720)1.81630304
159Molar tooth sign on MRI (HP:0002419)1.79540590
160Abnormality of midbrain morphology (HP:0002418)1.79540590
161Hypoplasia of the iris (HP:0007676)1.75540360
162Pancreatic cysts (HP:0001737)1.72294098
163Flared iliac wings (HP:0002869)1.71941216
164Microglossia (HP:0000171)1.71243490
165Vascular calcification (HP:0004934)1.68442009
166Nonimmune hydrops fetalis (HP:0001790)1.67780369
167Inguinal hernia (HP:0000023)1.67548653
168Hypoplasia of the odontoid process (HP:0003311)1.66162354
169Abnormality of the renal medulla (HP:0100957)1.65855866
170Torticollis (HP:0000473)1.57962222
171Pancreatic fibrosis (HP:0100732)1.57016956
172Camptodactyly of toe (HP:0001836)1.56936841
173Tubular atrophy (HP:0000092)1.55604443
174Long toe (HP:0010511)1.55101823
175Reduced subcutaneous adipose tissue (HP:0003758)1.55063593
176Morphological abnormality of the middle ear (HP:0008609)1.52075140
177Abnormality of skull ossification (HP:0002703)1.50772289
178Abnormal albumin level (HP:0012116)1.49957381
179Hypoalbuminemia (HP:0003073)1.49957381
180Aneurysm (HP:0002617)1.49738986
181Redundant skin (HP:0001582)1.49585540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.48819382
2TRIB35.39574146
3TTN3.47041893
4LATS23.29876483
5WNK43.04049861
6PDGFRA2.99917821
7MAP4K22.77236479
8BCKDK2.69292871
9FLT32.61625601
10LIMK12.49003832
11GRK72.45519704
12EPHB22.24766941
13PHKG22.13480616
14PHKG12.13480616
15LATS12.02442509
16PKN21.91425619
17ADRBK21.83397673
18STK38L1.78625342
19PDK41.77274532
20PDK31.77274532
21ERN11.76662424
22RIPK11.75988515
23GRK11.69017632
24EPHA31.66979729
25FGFR21.64238881
26MAP2K11.61004139
27PIM21.59497194
28NEK91.59328412
29CDK61.54533744
30WNK11.52625772
31OBSCN1.52520952
32NTRK11.45860811
33MUSK1.42798225
34ZAK1.35560744
35CDK191.32347147
36PIK3CA1.31164910
37PAK41.29969945
38PDK21.28671043
39DMPK1.26867684
40SIK11.26571896
41EIF2AK11.26490682
42MARK11.25440648
43ILK1.25180256
44MYLK1.23083515
45MAP3K31.19483977
46PAK21.19080604
47ERBB31.18358781
48FGFR11.17084139
49PRKD31.10310967
50PTK61.07955967
51SRPK11.07950038
52LMTK21.07561779
53PRKCE1.04175691
54PIK3CG1.03850569
55ADRBK11.00824567
56CASK0.98522232
57GRK50.94448950
58PDGFRB0.92371726
59AKT30.91024765
60MOS0.90921852
61ALK0.90869928
62PNCK0.90420082
63TRPM70.89469924
64STK380.88893066
65TAOK10.88764937
66WNK30.86747694
67FER0.86371762
68CAMK1G0.85202437
69CDC42BPA0.85107240
70JAK30.84160073
71STK390.82639915
72STK30.82442185
73PTK2B0.82124894
74MKNK10.79001259
75ROCK10.77410732
76PBK0.77050389
77DAPK30.76110647
78MAP3K120.76030343
79ROCK20.73244002
80INSRR0.73176085
81PAK60.68853978
82ABL20.68544801
83TLK10.68351600
84PRKD20.67540326
85PINK10.66946927
86BUB10.66594653
87TGFBR10.65872458
88BMPR1B0.65537358
89TRIM280.65523012
90RPS6KA40.64168175
91CAMK2D0.63779937
92NUAK10.63540861
93LRRK20.63467168
94PAK30.62612152
95PTK20.61716695
96CLK10.61026988
97BCR0.60771389
98STK40.57467432
99CDK90.57272915
100CAMK2A0.55846672
101CAMK1D0.55774577
102PAK10.55505536
103AKT20.55071006
104PLK40.54851766
105PLK30.54198722
106NEK20.53532869
107TTK0.52999235
108MAP2K70.52318997
109MET0.52104261
110MAPKAPK30.51552875
111MKNK20.50233498
112BMX0.48859278
113EPHB10.48121248
114MAP2K30.47573877
115MAPK120.46583817
116MTOR0.46495863
117NEK10.46419621
118DYRK20.46128454
119RPS6KB20.45780123
120RET0.43402936
121GSK3A0.43118076
122STK240.43042060
123PRKCG0.42649180
124MAP3K60.41523053
125CSNK1G30.41328105
126ERBB40.41228794
127CAMK10.40967873
128PRKG10.40943984
129DYRK30.39156072
130CSNK1A1L0.38774931
131PLK20.38253041
132NME10.36799239
133OXSR10.35801868
134RPS6KA20.35054403
135CDK140.34451108
136MAPKAPK50.34324896
137HIPK20.33455442
138CAMK2G0.33441577
139FRK0.32654567
140CSNK1A10.29768626
141MAP3K100.29592647
142TGFBR20.27998862
143ERBB20.26992859
144PRKD10.26696937
145CDK150.26412222
146MAPKAPK20.26304237
147ARAF0.26244016
148TESK10.26197582
149EEF2K0.26019558
150MAPK70.25985059
151RPS6KA60.25398228
152KIT0.24886366
153KSR20.24581554
154IGF1R0.20760644

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.66887712
2Protein export_Homo sapiens_hsa030603.53482967
3ECM-receptor interaction_Homo sapiens_hsa045123.21077888
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.81791224
5Propanoate metabolism_Homo sapiens_hsa006402.78766992
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.70421919
7Basal cell carcinoma_Homo sapiens_hsa052172.33461303
8Oxidative phosphorylation_Homo sapiens_hsa001902.22748574
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16441110
10Focal adhesion_Homo sapiens_hsa045102.15860511
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.07774653
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01648674
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.92877406
14Selenocompound metabolism_Homo sapiens_hsa004501.91812235
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.87740985
16Fatty acid degradation_Homo sapiens_hsa000711.86985775
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.83712192
18Hedgehog signaling pathway_Homo sapiens_hsa043401.80375281
19Protein digestion and absorption_Homo sapiens_hsa049741.77929638
20* Hippo signaling pathway_Homo sapiens_hsa043901.71498561
21Parkinsons disease_Homo sapiens_hsa050121.69959870
22Fatty acid metabolism_Homo sapiens_hsa012121.69862835
23Dilated cardiomyopathy_Homo sapiens_hsa054141.65537086
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64785085
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62425910
26Huntingtons disease_Homo sapiens_hsa050161.56176197
27RNA polymerase_Homo sapiens_hsa030201.55428161
28Phototransduction_Homo sapiens_hsa047441.54594807
29N-Glycan biosynthesis_Homo sapiens_hsa005101.52357550
30Proteoglycans in cancer_Homo sapiens_hsa052051.51573839
31PPAR signaling pathway_Homo sapiens_hsa033201.49619389
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49105585
33Basal transcription factors_Homo sapiens_hsa030221.48818850
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46909270
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45764759
36Chemical carcinogenesis_Homo sapiens_hsa052041.45053824
37Starch and sucrose metabolism_Homo sapiens_hsa005001.42111706
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42099680
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41620145
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38645532
41Glutathione metabolism_Homo sapiens_hsa004801.35507402
42Carbon metabolism_Homo sapiens_hsa012001.33647282
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.33554216
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30990699
45Adherens junction_Homo sapiens_hsa045201.23780953
46Tight junction_Homo sapiens_hsa045301.21585292
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.21301386
48Thyroid cancer_Homo sapiens_hsa052161.21285545
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20316215
50Insulin resistance_Homo sapiens_hsa049311.17412998
51Vibrio cholerae infection_Homo sapiens_hsa051101.17119815
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16782875
53Chronic myeloid leukemia_Homo sapiens_hsa052201.16621326
54Alzheimers disease_Homo sapiens_hsa050101.16120346
55Proteasome_Homo sapiens_hsa030501.14486610
56Sphingolipid metabolism_Homo sapiens_hsa006001.13757715
57Axon guidance_Homo sapiens_hsa043601.13653796
58AMPK signaling pathway_Homo sapiens_hsa041521.12010365
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11176908
60* TGF-beta signaling pathway_Homo sapiens_hsa043501.11159893
61Sulfur metabolism_Homo sapiens_hsa009201.06892941
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06801279
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03249015
64Bladder cancer_Homo sapiens_hsa052191.01745561
65Insulin signaling pathway_Homo sapiens_hsa049101.01165974
66Prostate cancer_Homo sapiens_hsa052151.01060761
67Glucagon signaling pathway_Homo sapiens_hsa049221.00987094
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99434843
69Pyrimidine metabolism_Homo sapiens_hsa002400.99367368
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96356524
71Wnt signaling pathway_Homo sapiens_hsa043100.95992012
72Circadian rhythm_Homo sapiens_hsa047100.95834171
73Amoebiasis_Homo sapiens_hsa051460.95488631
74Melanogenesis_Homo sapiens_hsa049160.95345091
75Asthma_Homo sapiens_hsa053100.93877771
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92209019
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92203970
78Galactose metabolism_Homo sapiens_hsa000520.91302510
79Small cell lung cancer_Homo sapiens_hsa052220.90153709
80Folate biosynthesis_Homo sapiens_hsa007900.89825156
81One carbon pool by folate_Homo sapiens_hsa006700.88471783
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85838100
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85208502
84Malaria_Homo sapiens_hsa051440.84520088
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82856033
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.82431552
87Biosynthesis of amino acids_Homo sapiens_hsa012300.81156026
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80888057
89Melanoma_Homo sapiens_hsa052180.77825204
90Butanoate metabolism_Homo sapiens_hsa006500.77109461
91Purine metabolism_Homo sapiens_hsa002300.76796095
92Non-small cell lung cancer_Homo sapiens_hsa052230.76760224
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76620612
94Glioma_Homo sapiens_hsa052140.76122977
95MicroRNAs in cancer_Homo sapiens_hsa052060.75370687
96Metabolic pathways_Homo sapiens_hsa011000.71514123
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69868772
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69433490
99Tyrosine metabolism_Homo sapiens_hsa003500.69190417
100Pathways in cancer_Homo sapiens_hsa052000.68570134
101Ribosome_Homo sapiens_hsa030100.67800055
102HTLV-I infection_Homo sapiens_hsa051660.67236465
103Pyruvate metabolism_Homo sapiens_hsa006200.66138570
104Cardiac muscle contraction_Homo sapiens_hsa042600.65726547
105beta-Alanine metabolism_Homo sapiens_hsa004100.64162893
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63963671
107* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63301365
108Sulfur relay system_Homo sapiens_hsa041220.63113642
109Steroid biosynthesis_Homo sapiens_hsa001000.62893052
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62154526
111Oxytocin signaling pathway_Homo sapiens_hsa049210.62117228
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61296065
113Renal cell carcinoma_Homo sapiens_hsa052110.60696471
114Gap junction_Homo sapiens_hsa045400.60292205
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59031551
116Notch signaling pathway_Homo sapiens_hsa043300.58361119
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57261193
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56671210
119Lysosome_Homo sapiens_hsa041420.56012955
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55717305
121Cocaine addiction_Homo sapiens_hsa050300.55450363
122GABAergic synapse_Homo sapiens_hsa047270.54893973
123HIF-1 signaling pathway_Homo sapiens_hsa040660.54580143
124Fanconi anemia pathway_Homo sapiens_hsa034600.54127351
125Peroxisome_Homo sapiens_hsa041460.52413420
126Fatty acid biosynthesis_Homo sapiens_hsa000610.51327161
127Fatty acid elongation_Homo sapiens_hsa000620.48675300
128FoxO signaling pathway_Homo sapiens_hsa040680.48519078
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.47701341
130Glycerolipid metabolism_Homo sapiens_hsa005610.46294253
131Renin secretion_Homo sapiens_hsa049240.46287669
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46175316
133Lysine degradation_Homo sapiens_hsa003100.45132356
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44694410
135Endometrial cancer_Homo sapiens_hsa052130.43862325
136Tryptophan metabolism_Homo sapiens_hsa003800.43754375
137Colorectal cancer_Homo sapiens_hsa052100.41247636
138Taste transduction_Homo sapiens_hsa047420.40453105
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40382416
140Viral myocarditis_Homo sapiens_hsa054160.39945459
141RNA degradation_Homo sapiens_hsa030180.39722548
142p53 signaling pathway_Homo sapiens_hsa041150.39024330
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38785864
144Morphine addiction_Homo sapiens_hsa050320.38660763
145Estrogen signaling pathway_Homo sapiens_hsa049150.37703191
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37465006
147Calcium signaling pathway_Homo sapiens_hsa040200.37221608
148Salivary secretion_Homo sapiens_hsa049700.36016799
149Gastric acid secretion_Homo sapiens_hsa049710.34593703
150MAPK signaling pathway_Homo sapiens_hsa040100.34424643
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.34304178
152Fructose and mannose metabolism_Homo sapiens_hsa000510.32249332
153Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30610710
154Nucleotide excision repair_Homo sapiens_hsa034200.29732731

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