ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	5.60640663
2	behavioral response to nicotine (GO:0035095)	4.61752490
3	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.13373281
4	piRNA metabolic process (GO:0034587)	3.75999883
5	platelet dense granule organization (GO:0060155)	3.74146635
6	detection of light stimulus involved in sensory perception (GO:0050962)	3.62514215
7	detection of light stimulus involved in visual perception (GO:0050908)	3.62514215
8	DNA deamination (GO:0045006)	3.61663183
9	tryptophan catabolic process (GO:0006569)	3.59975602
10	indole-containing compound catabolic process (GO:0042436)	3.59975602
11	indolalkylamine catabolic process (GO:0046218)	3.59975602
12	sulfation (GO:0051923)	3.52269706
13	cellular ketone body metabolic process (GO:0046950)	3.51541932
14	reflex (GO:0060004)	3.49703174
15	glycerophospholipid catabolic process (GO:0046475)	3.41306182
16	L-fucose catabolic process (GO:0042355)	3.35045481
17	fucose catabolic process (GO:0019317)	3.35045481
18	L-fucose metabolic process (GO:0042354)	3.35045481
19	startle response (GO:0001964)	3.24202004
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24051426
21	protein localization to cilium (GO:0061512)	3.22449742
22	indolalkylamine metabolic process (GO:0006586)	3.19140137
23	negative regulation of mast cell activation (GO:0033004)	3.17226333
24	ketone body metabolic process (GO:1902224)	3.15108039
25	regulation of hexokinase activity (GO:1903299)	3.14890587
26	regulation of glucokinase activity (GO:0033131)	3.14890587
27	cilium morphogenesis (GO:0060271)	3.13125148
28	respiratory chain complex IV assembly (GO:0008535)	3.13053706
29	epithelial cilium movement (GO:0003351)	3.12972351
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.12823935
31	response to pheromone (GO:0019236)	3.12384531
32	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.08062470
33	regulation of action potential (GO:0098900)	2.99163004
34	tryptophan metabolic process (GO:0006568)	2.99072526
35	protein complex biogenesis (GO:0070271)	2.98479415
36	serotonin receptor signaling pathway (GO:0007210)	2.98425615
37	cellular biogenic amine catabolic process (GO:0042402)	2.95951954
38	amine catabolic process (GO:0009310)	2.95951954
39	protein-cofactor linkage (GO:0018065)	2.94375407
40	regulation of cilium movement (GO:0003352)	2.93246917
41	negative regulation of telomere maintenance (GO:0032205)	2.91323194
42	proline transport (GO:0015824)	2.86932019
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.86143985
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.86143985
45	NADH dehydrogenase complex assembly (GO:0010257)	2.86143985
46	thyroid hormone metabolic process (GO:0042403)	2.83970944
47	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.80855015
48	nonmotile primary cilium assembly (GO:0035058)	2.79676919
49	dopamine transport (GO:0015872)	2.79517502
50	kidney morphogenesis (GO:0060993)	2.79488171
51	kynurenine metabolic process (GO:0070189)	2.79048878
52	retinal cone cell development (GO:0046549)	2.77955712
53	DNA methylation involved in gamete generation (GO:0043046)	2.76324076
54	neural tube formation (GO:0001841)	2.75974356
55	indole-containing compound metabolic process (GO:0042430)	2.75838313
56	cytochrome complex assembly (GO:0017004)	2.74801076
57	axoneme assembly (GO:0035082)	2.74200285
58	synaptic transmission, cholinergic (GO:0007271)	2.73498907
59	photoreceptor cell maintenance (GO:0045494)	2.72257680
60	photoreceptor cell development (GO:0042461)	2.70048305
61	nephron epithelium morphogenesis (GO:0072088)	2.67119900
62	nephron tubule morphogenesis (GO:0072078)	2.67119900
63	gamma-aminobutyric acid transport (GO:0015812)	2.65924854
64	cornea development in camera-type eye (GO:0061303)	2.65656857
65	neuronal action potential (GO:0019228)	2.65251557
66	establishment of protein localization to Golgi (GO:0072600)	2.63834721
67	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.63656274
68	protein polyglutamylation (GO:0018095)	2.63147512
69	regulation of neurotransmitter uptake (GO:0051580)	2.61020067
70	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.60978239
71	auditory receptor cell stereocilium organization (GO:0060088)	2.60963801
72	behavioral response to ethanol (GO:0048149)	2.60761292
73	mitochondrial respiratory chain complex assembly (GO:0033108)	2.59537560
74	adaptation of signaling pathway (GO:0023058)	2.58904009
75	primary amino compound metabolic process (GO:1901160)	2.58402064
76	regulation of hippo signaling (GO:0035330)	2.56344316
77	peristalsis (GO:0030432)	2.56327302
78	cilium movement (GO:0003341)	2.54419850
79	centriole replication (GO:0007099)	2.53590136
80	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.52009009
81	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.52009009
82	nucleobase catabolic process (GO:0046113)	2.51473221
83	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.50689355
84	rhodopsin mediated signaling pathway (GO:0016056)	2.50467684
85	pyrimidine nucleobase catabolic process (GO:0006208)	2.50189510
86	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.50001625
87	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.49648207
88	cilium organization (GO:0044782)	2.48898328
89	mannosylation (GO:0097502)	2.48759447
90	preassembly of GPI anchor in ER membrane (GO:0016254)	2.46969871
91	organic cation transport (GO:0015695)	2.45531143
92	cilium or flagellum-dependent cell motility (GO:0001539)	2.45407223
93	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.44656454
94	serotonin metabolic process (GO:0042428)	2.44171221
95	eye photoreceptor cell development (GO:0042462)	2.43754677
96	cilium assembly (GO:0042384)	2.42580962
97	aromatic amino acid family catabolic process (GO:0009074)	2.42541209
98	protein K6-linked ubiquitination (GO:0085020)	2.42196615
99	inner ear receptor stereocilium organization (GO:0060122)	2.41817548
100	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.40063362

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.62150847
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.59843998
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.39950008
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.04590796
5	VDR_22108803_ChIP-Seq_LS180_Human	2.73336743
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64610445
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.59484051
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36183957
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.35293822
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31256552
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.14742521
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.14602210
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.09850615
14	P300_19829295_ChIP-Seq_ESCs_Human	1.97018401
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.96114506
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96093911
17	EWS_26573619_Chip-Seq_HEK293_Human	1.92963418
18	FUS_26573619_Chip-Seq_HEK293_Human	1.89611144
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85143281
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82776336
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.81099219
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74198454
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.71923630
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.67568923
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.58498303
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57160300
27	STAT3_23295773_ChIP-Seq_U87_Human	1.57136653
28	AR_25329375_ChIP-Seq_VCAP_Human	1.55966187
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54510096
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.53886331
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52316184
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50892847
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50696650
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.50696650
35	TCF4_23295773_ChIP-Seq_U87_Human	1.49614255
36	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.48357201
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48223935
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.46206213
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44521981
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44508463
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43954746
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37740626
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37740626
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34349227
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33950313
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33950313
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33194581
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32105537
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31335520
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31273705
51	AR_21572438_ChIP-Seq_LNCaP_Human	1.31071925
52	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.30492835
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.29897902
54	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29731218
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.28733413
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28533898
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28276525
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27906529
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27388563
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27255776
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.27076063
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.26556013
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24804049
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24693875
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23701159
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22235183
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21715730
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19727903
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19727903
70	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17833270
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17570179
72	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.17469744
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15482749
74	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15387571
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14295469
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13365350
77	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.13180312
78	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10526414
79	NCOR_22424771_ChIP-Seq_293T_Human	1.10423993
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09004034
81	CDX2_22108803_ChIP-Seq_LS180_Human	1.08772945
82	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07486670
83	AR_20517297_ChIP-Seq_VCAP_Human	1.07260715
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07145720
85	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06862870
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05713465
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03609743
88	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03498353
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01814818
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01810658
91	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.01710317
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01655908
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98686368
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97447175
95	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.96258828
96	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95930907
97	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95511139
98	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.94807370
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92951137
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92865099

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.44781627
2	MP0002102_abnormal_ear_morphology	3.40034209
3	MP0002837_dystrophic_cardiac_calcinosis	2.95389299
4	MP0008877_abnormal_DNA_methylation	2.93042318
5	MP0005551_abnormal_eye_electrophysiolog	2.80556257
6	MP0000569_abnormal_digit_pigmentation	2.55372465
7	MP0005645_abnormal_hypothalamus_physiol	2.31848356
8	MP0008875_abnormal_xenobiotic_pharmacok	2.31004545
9	MP0009046_muscle_twitch	2.30627397
10	MP0001986_abnormal_taste_sensitivity	2.19933406
11	MP0001968_abnormal_touch/_nociception	2.13953575
12	MP0008872_abnormal_physiological_respon	2.13627628
13	MP0006072_abnormal_retinal_apoptosis	2.00923817
14	MP0001984_abnormal_olfaction	1.96434405
15	MP0005646_abnormal_pituitary_gland	1.96057684
16	MP0005379_endocrine/exocrine_gland_phen	1.89913251
17	MP0002876_abnormal_thyroid_physiology	1.87906312
18	MP0009745_abnormal_behavioral_response	1.83772531
19	MP0004142_abnormal_muscle_tone	1.82609005
20	MP0004043_abnormal_pH_regulation	1.82466662
21	MP0005253_abnormal_eye_physiology	1.82394384
22	MP0002163_abnormal_gland_morphology	1.81944745
23	MP0000427_abnormal_hair_cycle	1.77515829
24	MP0002272_abnormal_nervous_system	1.74828788
25	MP0000372_irregular_coat_pigmentation	1.74027460
26	MP0004885_abnormal_endolymph	1.71906032
27	MP0010386_abnormal_urinary_bladder	1.65600577
28	MP0003787_abnormal_imprinting	1.65570985
29	MP0003880_abnormal_central_pattern	1.63627175
30	MP0001486_abnormal_startle_reflex	1.56013459
31	MP0003646_muscle_fatigue	1.54771660
32	MP0000383_abnormal_hair_follicle	1.47736366
33	MP0006276_abnormal_autonomic_nervous	1.46730496
34	MP0005174_abnormal_tail_pigmentation	1.42525485
35	MP0002064_seizures	1.42411653
36	MP0005084_abnormal_gallbladder_morpholo	1.39501246
37	MP0001501_abnormal_sleep_pattern	1.37735679
38	MP0002736_abnormal_nociception_after	1.37610742
39	MP0000631_abnormal_neuroendocrine_gland	1.37187288
40	MP0004742_abnormal_vestibular_system	1.36939306
41	MP0001485_abnormal_pinna_reflex	1.30020708
42	MP0002938_white_spotting	1.25055242
43	MP0002928_abnormal_bile_duct	1.24494609
44	MP0002572_abnormal_emotion/affect_behav	1.22276745
45	MP0002638_abnormal_pupillary_reflex	1.22182721
46	MP0003122_maternal_imprinting	1.20730627
47	MP0005389_reproductive_system_phenotype	1.19885645
48	MP0003011_delayed_dark_adaptation	1.19047939
49	MP0001970_abnormal_pain_threshold	1.18807417
50	MP0002160_abnormal_reproductive_system	1.17870292
51	MP0005310_abnormal_salivary_gland	1.17662076
52	MP0003136_yellow_coat_color	1.14429049
53	MP0001905_abnormal_dopamine_level	1.13575707
54	MP0002557_abnormal_social/conspecific_i	1.13487606
55	MP0000613_abnormal_salivary_gland	1.12296821
56	MP0001502_abnormal_circadian_rhythm	1.09577219
57	MP0002909_abnormal_adrenal_gland	1.09049298
58	MP0010329_abnormal_lipoprotein_level	1.08895435
59	MP0002735_abnormal_chemical_nociception	1.06258261
60	MP0001919_abnormal_reproductive_system	1.06206995
61	MP0005377_hearing/vestibular/ear_phenot	1.06132914
62	MP0003878_abnormal_ear_physiology	1.06132914
63	MP0004924_abnormal_behavior	1.05493527
64	MP0005386_behavior/neurological_phenoty	1.05493527
65	MP0002067_abnormal_sensory_capabilities	1.05457641
66	MP0002733_abnormal_thermal_nociception	1.05064782
67	MP0002653_abnormal_ependyma_morphology	1.03661910
68	MP0003635_abnormal_synaptic_transmissio	1.02251738
69	MP0004133_heterotaxia	0.99875588
70	MP0005195_abnormal_posterior_eye	0.98134911
71	MP0002734_abnormal_mechanical_nocicepti	0.97916399
72	MP0002693_abnormal_pancreas_physiology	0.97544824
73	MP0005332_abnormal_amino_acid	0.95664689
74	MP0009780_abnormal_chondrocyte_physiolo	0.95510981
75	MP0003283_abnormal_digestive_organ	0.94392022
76	MP0004215_abnormal_myocardial_fiber	0.92907689
77	MP0005167_abnormal_blood-brain_barrier	0.91635127
78	MP0002063_abnormal_learning/memory/cond	0.91327942
79	MP0005410_abnormal_fertilization	0.91211291
80	MP0000230_abnormal_systemic_arterial	0.90998591
81	MP0001324_abnormal_eye_pigmentation	0.89668867
82	MP0002229_neurodegeneration	0.88997990
83	MP0008995_early_reproductive_senescence	0.88959761
84	MP0002277_abnormal_respiratory_mucosa	0.88577277
85	MP0003252_abnormal_bile_duct	0.87475415
86	MP0005670_abnormal_white_adipose	0.86461187
87	MP0003718_maternal_effect	0.86435402
88	MP0000026_abnormal_inner_ear	0.86178139
89	MP0000647_abnormal_sebaceous_gland	0.85463578
90	MP0003698_abnormal_male_reproductive	0.85362361
91	MP0003121_genomic_imprinting	0.85064454
92	MP0001529_abnormal_vocalization	0.84599940
93	MP0008789_abnormal_olfactory_epithelium	0.83089420
94	MP0001764_abnormal_homeostasis	0.82916176
95	MP0001944_abnormal_pancreas_morphology	0.82493275
96	MP0006292_abnormal_olfactory_placode	0.81865379
97	MP0002752_abnormal_somatic_nervous	0.81619563
98	MP0002184_abnormal_innervation	0.81205200
99	MP0003137_abnormal_impulse_conducting	0.80085502
100	MP0000538_abnormal_urinary_bladder	0.79270033

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.36884403
2	Molar tooth sign on MRI (HP:0002419)	4.23423649
3	Abnormality of midbrain morphology (HP:0002418)	4.23423649
4	Congenital stationary night blindness (HP:0007642)	3.99195267
5	True hermaphroditism (HP:0010459)	3.96824100
6	Pancreatic fibrosis (HP:0100732)	3.94934624
7	Nephronophthisis (HP:0000090)	3.40581308
8	Type II lissencephaly (HP:0007260)	3.40021078
9	Hyperventilation (HP:0002883)	3.24802827
10	Abnormality of the renal cortex (HP:0011035)	3.20814470
11	Medial flaring of the eyebrow (HP:0010747)	3.11245239
12	Abnormal drinking behavior (HP:0030082)	2.95686339
13	Polydipsia (HP:0001959)	2.95686339
14	Abnormality of the renal medulla (HP:0100957)	2.93963996
15	Attenuation of retinal blood vessels (HP:0007843)	2.93677617
16	Abolished electroretinogram (ERG) (HP:0000550)	2.76904774
17	Large for gestational age (HP:0001520)	2.73080598
18	Cystic liver disease (HP:0006706)	2.71681652
19	Tubular atrophy (HP:0000092)	2.65180015
20	Polyuria (HP:0000103)	2.56285925
21	Pendular nystagmus (HP:0012043)	2.55164276
22	Lissencephaly (HP:0001339)	2.55155548
23	Chronic hepatic failure (HP:0100626)	2.53715052
24	Gaze-evoked nystagmus (HP:0000640)	2.51284169
25	Hemiparesis (HP:0001269)	2.46006658
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.44132171
27	Absent speech (HP:0001344)	2.42615277
28	Inability to walk (HP:0002540)	2.39632594
29	Gait imbalance (HP:0002141)	2.38673332
30	Renal cortical cysts (HP:0000803)	2.35965018
31	Decreased central vision (HP:0007663)	2.34927756
32	Mitochondrial inheritance (HP:0001427)	2.33245809
33	Optic nerve hypoplasia (HP:0000609)	2.33017350
34	Congenital sensorineural hearing impairment (HP:0008527)	2.32563744
35	Cerebellar dysplasia (HP:0007033)	2.31982843
36	Congenital primary aphakia (HP:0007707)	2.31723799
37	Furrowed tongue (HP:0000221)	2.30221571
38	Increased CSF lactate (HP:0002490)	2.29635785
39	Febrile seizures (HP:0002373)	2.26141755
40	Acute necrotizing encephalopathy (HP:0006965)	2.25700885
41	Keratoconus (HP:0000563)	2.25597902
42	Increased corneal curvature (HP:0100692)	2.25597902
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.25056304
44	Hepatic necrosis (HP:0002605)	2.21637206
45	Pachygyria (HP:0001302)	2.19537030
46	Progressive macrocephaly (HP:0004481)	2.18677811
47	Ketoacidosis (HP:0001993)	2.16540491
48	Nephrogenic diabetes insipidus (HP:0009806)	2.13364445
49	Bile duct proliferation (HP:0001408)	2.12661471
50	Abnormal biliary tract physiology (HP:0012439)	2.12661471
51	Tachypnea (HP:0002789)	2.12561171
52	Hyperalaninemia (HP:0003348)	2.12051183
53	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.12051183
54	Abnormality of alanine metabolism (HP:0010916)	2.12051183
55	Hepatocellular necrosis (HP:0001404)	2.10159472
56	Broad-based gait (HP:0002136)	2.09807866
57	Severe muscular hypotonia (HP:0006829)	2.09330745
58	Genital tract atresia (HP:0001827)	2.08915481
59	Methylmalonic acidemia (HP:0002912)	2.08803673
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.07522486
61	Hypomagnesemia (HP:0002917)	2.06670250
62	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.05796283
63	Acute encephalopathy (HP:0006846)	2.05741426
64	Abnormal urine output (HP:0012590)	2.05088394
65	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.02700728
66	Abnormality of the labia minora (HP:0012880)	2.02387531
67	Hypothermia (HP:0002045)	2.01468454
68	Sclerocornea (HP:0000647)	2.01083206
69	Fair hair (HP:0002286)	2.00077398
70	Vaginal atresia (HP:0000148)	1.99306426
71	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.97861298
72	Bony spicule pigmentary retinopathy (HP:0007737)	1.97816601
73	Male pseudohermaphroditism (HP:0000037)	1.97093245
74	Neoplasm of the adrenal cortex (HP:0100641)	1.96652093
75	Congenital, generalized hypertrichosis (HP:0004540)	1.96625174
76	Progressive cerebellar ataxia (HP:0002073)	1.95272689
77	Decreased circulating renin level (HP:0003351)	1.95187340
78	Congenital hepatic fibrosis (HP:0002612)	1.92367208
79	Ketosis (HP:0001946)	1.89622396
80	Progressive inability to walk (HP:0002505)	1.89453041
81	Intestinal atresia (HP:0011100)	1.88381186
82	Abnormality of renal excretion (HP:0011036)	1.86654235
83	Polyphagia (HP:0002591)	1.86592007
84	Lipid accumulation in hepatocytes (HP:0006561)	1.85789384
85	Anencephaly (HP:0002323)	1.84851838
86	Hyperglycinuria (HP:0003108)	1.82953265
87	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.81721865
88	Absent/shortened dynein arms (HP:0200106)	1.81721865
89	Agitation (HP:0000713)	1.81516718
90	Abnormal mitochondria in muscle tissue (HP:0008316)	1.78147478
91	Mesangial abnormality (HP:0001966)	1.77684924
92	Widely spaced teeth (HP:0000687)	1.77367952
93	Clumsiness (HP:0002312)	1.77215391
94	Abnormality of urine glucose concentration (HP:0011016)	1.76606911
95	Glycosuria (HP:0003076)	1.76606911
96	Small hand (HP:0200055)	1.75716053
97	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.75102968
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.74936992
99	Stomach cancer (HP:0012126)	1.74049521
100	Methylmalonic aciduria (HP:0012120)	1.73887071

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.18374547
2	ADRBK2	3.71885673
3	WNK3	3.24149399
4	PINK1	2.99376599
5	GRK1	2.76476038
6	ZAK	2.72920882
7	CASK	2.35906006
8	WNK4	2.30086635
9	MAP4K2	2.16861499
10	NUAK1	2.09748370
11	BRSK2	1.94535199
12	TAOK3	1.94058561
13	MAPK13	1.83693160
14	CAMKK2	1.81326441
15	BMPR1B	1.77501802
16	MAP3K4	1.70827861
17	STK39	1.60378425
18	DAPK2	1.59221268
19	OXSR1	1.51633684
20	TXK	1.40231121
21	TRIM28	1.38698956
22	MUSK	1.36222477
23	DYRK2	1.30655680
24	PAK3	1.24740244
25	ACVR1B	1.23040958
26	MAPKAPK5	1.20102693
27	INSRR	1.18130771
28	TLK1	1.17034019
29	MARK1	1.11233862
30	MAP2K7	1.10055258
31	ADRBK1	1.08301712
32	NEK2	1.07512090
33	PRKCE	1.07077699
34	MST4	1.06748486
35	TNIK	1.06267594
36	VRK2	1.01591858
37	EPHA4	1.01055858
38	WEE1	1.00717596
39	FGFR2	1.00277460
40	CSNK1G2	1.00136392
41	PRKCG	0.94674270
42	CSNK1G1	0.94465754
43	STK38L	0.93582261
44	MKNK2	0.92424060
45	PNCK	0.90935669
46	NTRK3	0.90208338
47	CSNK1G3	0.88222056
48	MAPKAPK3	0.84734598
49	PHKG2	0.83887902
50	PHKG1	0.83887902
51	PLK2	0.81850882
52	VRK1	0.78677598
53	GRK5	0.75223306
54	CCNB1	0.72606486
55	CSNK1A1L	0.71693289
56	PIK3CA	0.66893901
57	PTK2B	0.65023996
58	EPHB2	0.64510175
59	CAMK1	0.63827719
60	MAP2K6	0.62620747
61	TSSK6	0.61087005
62	FER	0.60944737
63	RPS6KA5	0.57340245
64	CAMK2A	0.56750769
65	TAF1	0.56239640
66	PLK3	0.55835881
67	STK3	0.52844724
68	IKBKB	0.51989015
69	CAMK1D	0.51249013
70	ERBB3	0.50914029
71	BCR	0.49946530
72	CAMK1G	0.48795632
73	EPHA3	0.48205745
74	TNK2	0.46843004
75	PRKACA	0.46394121
76	PKN1	0.45049785
77	IRAK1	0.44093538
78	BCKDK	0.44051655
79	MAP2K4	0.42207147
80	PRKCZ	0.40419334
81	NME1	0.40348417
82	EIF2AK3	0.40117601
83	PRKCI	0.39852701
84	TIE1	0.38977935
85	CSNK1A1	0.38714533
86	PRKCQ	0.38676638
87	CSNK1D	0.36291560
88	PRKCA	0.36190737
89	CAMK2D	0.35332862
90	CHUK	0.34860401
91	PRKG1	0.33741517
92	HIPK2	0.32102054
93	NTRK2	0.31842517
94	BLK	0.30752438
95	TGFBR1	0.29506017
96	NLK	0.29158036
97	NEK1	0.28849887
98	PRKAA2	0.28542142
99	LMTK2	0.28310178
100	STK11	0.26372263

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.96512904
2	Selenocompound metabolism_Homo sapiens_hsa00450	2.75999074
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.60355422
4	Butanoate metabolism_Homo sapiens_hsa00650	2.59638777
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.56963265
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.54302246
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.45907602
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.44408071
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.34183669
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.19806218
11	Ether lipid metabolism_Homo sapiens_hsa00565	2.15116234
12	Nicotine addiction_Homo sapiens_hsa05033	2.02691897
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.02690116
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.01332866
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.99636888
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95479304
17	Protein export_Homo sapiens_hsa03060	1.90007507
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.69497030
19	Regulation of autophagy_Homo sapiens_hsa04140	1.67771366
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.65311234
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.63232145
22	Parkinsons disease_Homo sapiens_hsa05012	1.61525062
23	Propanoate metabolism_Homo sapiens_hsa00640	1.56801630
24	Caffeine metabolism_Homo sapiens_hsa00232	1.45994231
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.35712034
26	Peroxisome_Homo sapiens_hsa04146	1.34857757
27	Insulin secretion_Homo sapiens_hsa04911	1.28858883
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.28012216
29	Morphine addiction_Homo sapiens_hsa05032	1.25629820
30	Homologous recombination_Homo sapiens_hsa03440	1.24722296
31	Basal transcription factors_Homo sapiens_hsa03022	1.23693429
32	Taste transduction_Homo sapiens_hsa04742	1.23280655
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.21793736
34	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.20841914
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.16830090
36	RNA polymerase_Homo sapiens_hsa03020	1.12941528
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12223498
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05953411
39	Olfactory transduction_Homo sapiens_hsa04740	1.03844804
40	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.01168627
41	ABC transporters_Homo sapiens_hsa02010	0.99131917
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98350520
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98292421
44	Huntingtons disease_Homo sapiens_hsa05016	0.96753691
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95043984
46	GABAergic synapse_Homo sapiens_hsa04727	0.94765798
47	Serotonergic synapse_Homo sapiens_hsa04726	0.94499829
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.94346066
49	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.92450992
50	Circadian entrainment_Homo sapiens_hsa04713	0.92154042
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.91186466
52	Mineral absorption_Homo sapiens_hsa04978	0.89252681
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86968144
54	Proteasome_Homo sapiens_hsa03050	0.86736068
55	Alzheimers disease_Homo sapiens_hsa05010	0.85117987
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.84466945
57	Sulfur metabolism_Homo sapiens_hsa00920	0.83407917
58	RNA degradation_Homo sapiens_hsa03018	0.83234372
59	Fatty acid degradation_Homo sapiens_hsa00071	0.82981294
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82978953
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79122246
62	Salivary secretion_Homo sapiens_hsa04970	0.78465372
63	Retinol metabolism_Homo sapiens_hsa00830	0.78095866
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76214151
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.76204180
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.75765997
67	Histidine metabolism_Homo sapiens_hsa00340	0.75708924
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.72858431
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71431707
70	One carbon pool by folate_Homo sapiens_hsa00670	0.71301843
71	Metabolic pathways_Homo sapiens_hsa01100	0.65613816
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64185679
73	Fatty acid elongation_Homo sapiens_hsa00062	0.62432445
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.62108569
75	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.62004001
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59764085
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57452864
78	Type I diabetes mellitus_Homo sapiens_hsa04940	0.57055403
79	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55475858
80	Purine metabolism_Homo sapiens_hsa00230	0.54535634
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50853706
82	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49692039
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49591345
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.48268245
85	Glutathione metabolism_Homo sapiens_hsa00480	0.47414328
86	Circadian rhythm_Homo sapiens_hsa04710	0.44778320
87	Dopaminergic synapse_Homo sapiens_hsa04728	0.43940275
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.42278896
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42028742
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.41241051
91	Cocaine addiction_Homo sapiens_hsa05030	0.40025365
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39152965
93	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.38324677
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37507395
95	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.34545769
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.33716092
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.32697225
98	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.32696056
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31398537
100	Amphetamine addiction_Homo sapiens_hsa05031	0.30656129

GDF5OS

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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