GDF5OS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)5.60640663
2behavioral response to nicotine (GO:0035095)4.61752490
3detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.13373281
4piRNA metabolic process (GO:0034587)3.75999883
5platelet dense granule organization (GO:0060155)3.74146635
6detection of light stimulus involved in sensory perception (GO:0050962)3.62514215
7detection of light stimulus involved in visual perception (GO:0050908)3.62514215
8DNA deamination (GO:0045006)3.61663183
9tryptophan catabolic process (GO:0006569)3.59975602
10indole-containing compound catabolic process (GO:0042436)3.59975602
11indolalkylamine catabolic process (GO:0046218)3.59975602
12sulfation (GO:0051923)3.52269706
13cellular ketone body metabolic process (GO:0046950)3.51541932
14reflex (GO:0060004)3.49703174
15glycerophospholipid catabolic process (GO:0046475)3.41306182
16fucose catabolic process (GO:0019317)3.35045481
17L-fucose metabolic process (GO:0042354)3.35045481
18L-fucose catabolic process (GO:0042355)3.35045481
19startle response (GO:0001964)3.24202004
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24051426
21protein localization to cilium (GO:0061512)3.22449742
22indolalkylamine metabolic process (GO:0006586)3.19140137
23negative regulation of mast cell activation (GO:0033004)3.17226333
24ketone body metabolic process (GO:1902224)3.15108039
25regulation of hexokinase activity (GO:1903299)3.14890587
26regulation of glucokinase activity (GO:0033131)3.14890587
27cilium morphogenesis (GO:0060271)3.13125148
28respiratory chain complex IV assembly (GO:0008535)3.13053706
29epithelial cilium movement (GO:0003351)3.12972351
30water-soluble vitamin biosynthetic process (GO:0042364)3.12823935
31response to pheromone (GO:0019236)3.12384531
32phosphatidylinositol acyl-chain remodeling (GO:0036149)3.08062470
33regulation of action potential (GO:0098900)2.99163004
34tryptophan metabolic process (GO:0006568)2.99072526
35protein complex biogenesis (GO:0070271)2.98479415
36serotonin receptor signaling pathway (GO:0007210)2.98425615
37cellular biogenic amine catabolic process (GO:0042402)2.95951954
38amine catabolic process (GO:0009310)2.95951954
39protein-cofactor linkage (GO:0018065)2.94375407
40regulation of cilium movement (GO:0003352)2.93246917
41negative regulation of telomere maintenance (GO:0032205)2.91323194
42proline transport (GO:0015824)2.86932019
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86143985
44mitochondrial respiratory chain complex I assembly (GO:0032981)2.86143985
45NADH dehydrogenase complex assembly (GO:0010257)2.86143985
46thyroid hormone metabolic process (GO:0042403)2.83970944
47negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80855015
48nonmotile primary cilium assembly (GO:0035058)2.79676919
49dopamine transport (GO:0015872)2.79517502
50kidney morphogenesis (GO:0060993)2.79488171
51kynurenine metabolic process (GO:0070189)2.79048878
52retinal cone cell development (GO:0046549)2.77955712
53DNA methylation involved in gamete generation (GO:0043046)2.76324076
54neural tube formation (GO:0001841)2.75974356
55indole-containing compound metabolic process (GO:0042430)2.75838313
56cytochrome complex assembly (GO:0017004)2.74801076
57axoneme assembly (GO:0035082)2.74200285
58synaptic transmission, cholinergic (GO:0007271)2.73498907
59photoreceptor cell maintenance (GO:0045494)2.72257680
60photoreceptor cell development (GO:0042461)2.70048305
61nephron tubule morphogenesis (GO:0072078)2.67119900
62nephron epithelium morphogenesis (GO:0072088)2.67119900
63gamma-aminobutyric acid transport (GO:0015812)2.65924854
64cornea development in camera-type eye (GO:0061303)2.65656857
65neuronal action potential (GO:0019228)2.65251557
66establishment of protein localization to Golgi (GO:0072600)2.63834721
67negative regulation of synaptic transmission, GABAergic (GO:0032229)2.63656274
68protein polyglutamylation (GO:0018095)2.63147512
69regulation of neurotransmitter uptake (GO:0051580)2.61020067
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.60978239
71auditory receptor cell stereocilium organization (GO:0060088)2.60963801
72behavioral response to ethanol (GO:0048149)2.60761292
73mitochondrial respiratory chain complex assembly (GO:0033108)2.59537560
74adaptation of signaling pathway (GO:0023058)2.58904009
75primary amino compound metabolic process (GO:1901160)2.58402064
76regulation of hippo signaling (GO:0035330)2.56344316
77peristalsis (GO:0030432)2.56327302
78cilium movement (GO:0003341)2.54419850
79centriole replication (GO:0007099)2.53590136
803-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.52009009
81purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.52009009
82nucleobase catabolic process (GO:0046113)2.51473221
83regulation of nuclear cell cycle DNA replication (GO:0033262)2.50689355
84rhodopsin mediated signaling pathway (GO:0016056)2.50467684
85pyrimidine nucleobase catabolic process (GO:0006208)2.50189510
86regulation of rhodopsin mediated signaling pathway (GO:0022400)2.50001625
87phosphatidylserine acyl-chain remodeling (GO:0036150)2.49648207
88cilium organization (GO:0044782)2.48898328
89mannosylation (GO:0097502)2.48759447
90preassembly of GPI anchor in ER membrane (GO:0016254)2.46969871
91organic cation transport (GO:0015695)2.45531143
92cilium or flagellum-dependent cell motility (GO:0001539)2.45407223
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.44656454
94serotonin metabolic process (GO:0042428)2.44171221
95eye photoreceptor cell development (GO:0042462)2.43754677
96cilium assembly (GO:0042384)2.42580962
97aromatic amino acid family catabolic process (GO:0009074)2.42541209
98protein K6-linked ubiquitination (GO:0085020)2.42196615
99inner ear receptor stereocilium organization (GO:0060122)2.41817548
100detection of mechanical stimulus involved in sensory perception (GO:0050974)2.40063362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.62150847
2GBX2_23144817_ChIP-Seq_PC3_Human3.59843998
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.39950008
4IGF1R_20145208_ChIP-Seq_DFB_Human3.04590796
5VDR_22108803_ChIP-Seq_LS180_Human2.73336743
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64610445
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59484051
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36183957
9EZH2_22144423_ChIP-Seq_EOC_Human2.35293822
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.31256552
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14742521
12TAF15_26573619_Chip-Seq_HEK293_Human2.14602210
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09850615
14P300_19829295_ChIP-Seq_ESCs_Human1.97018401
15ER_23166858_ChIP-Seq_MCF-7_Human1.96114506
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96093911
17EWS_26573619_Chip-Seq_HEK293_Human1.92963418
18FUS_26573619_Chip-Seq_HEK293_Human1.89611144
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85143281
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82776336
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.81099219
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74198454
23BCAT_22108803_ChIP-Seq_LS180_Human1.71923630
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67568923
25SMAD4_21799915_ChIP-Seq_A2780_Human1.58498303
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57160300
27STAT3_23295773_ChIP-Seq_U87_Human1.57136653
28AR_25329375_ChIP-Seq_VCAP_Human1.55966187
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54510096
30TP53_22573176_ChIP-Seq_HFKS_Human1.53886331
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.52316184
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50892847
33CBP_20019798_ChIP-Seq_JUKART_Human1.50696650
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50696650
35TCF4_23295773_ChIP-Seq_U87_Human1.49614255
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48357201
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48223935
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46206213
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44521981
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44508463
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43954746
42NANOG_19829295_ChIP-Seq_ESCs_Human1.37740626
43SOX2_19829295_ChIP-Seq_ESCs_Human1.37740626
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.34349227
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.33950313
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33950313
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33194581
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32105537
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.31335520
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31273705
51AR_21572438_ChIP-Seq_LNCaP_Human1.31071925
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30492835
53TCF4_22108803_ChIP-Seq_LS180_Human1.29897902
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29731218
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.28733413
56REST_21632747_ChIP-Seq_MESCs_Mouse1.28533898
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.28276525
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27906529
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27388563
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27255776
61MYC_18940864_ChIP-ChIP_HL60_Human1.27076063
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26556013
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.24804049
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24693875
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.23701159
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22235183
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.21715730
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19727903
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19727903
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17833270
71RUNX2_22187159_ChIP-Seq_PCA_Human1.17570179
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17469744
73IRF1_19129219_ChIP-ChIP_H3396_Human1.15482749
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.15387571
75HOXB7_26014856_ChIP-Seq_BT474_Human1.14295469
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.13365350
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.13180312
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10526414
79NCOR_22424771_ChIP-Seq_293T_Human1.10423993
80RNF2_27304074_Chip-Seq_NSC_Mouse1.09004034
81CDX2_22108803_ChIP-Seq_LS180_Human1.08772945
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07486670
83AR_20517297_ChIP-Seq_VCAP_Human1.07260715
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.07145720
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06862870
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.05713465
87P53_22387025_ChIP-Seq_ESCs_Mouse1.03609743
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03498353
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01814818
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01810658
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01710317
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.01655908
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98686368
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97447175
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96258828
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95930907
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95511139
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94807370
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92951137
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92865099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.44781627
2MP0002102_abnormal_ear_morphology3.40034209
3MP0002837_dystrophic_cardiac_calcinosis2.95389299
4MP0008877_abnormal_DNA_methylation2.93042318
5MP0005551_abnormal_eye_electrophysiolog2.80556257
6MP0000569_abnormal_digit_pigmentation2.55372465
7MP0005645_abnormal_hypothalamus_physiol2.31848356
8MP0008875_abnormal_xenobiotic_pharmacok2.31004545
9MP0009046_muscle_twitch2.30627397
10MP0001986_abnormal_taste_sensitivity2.19933406
11MP0001968_abnormal_touch/_nociception2.13953575
12MP0008872_abnormal_physiological_respon2.13627628
13MP0006072_abnormal_retinal_apoptosis2.00923817
14MP0001984_abnormal_olfaction1.96434405
15MP0005646_abnormal_pituitary_gland1.96057684
16MP0005379_endocrine/exocrine_gland_phen1.89913251
17MP0002876_abnormal_thyroid_physiology1.87906312
18MP0009745_abnormal_behavioral_response1.83772531
19MP0004142_abnormal_muscle_tone1.82609005
20MP0004043_abnormal_pH_regulation1.82466662
21MP0005253_abnormal_eye_physiology1.82394384
22MP0002163_abnormal_gland_morphology1.81944745
23MP0000427_abnormal_hair_cycle1.77515829
24MP0002272_abnormal_nervous_system1.74828788
25MP0000372_irregular_coat_pigmentation1.74027460
26MP0004885_abnormal_endolymph1.71906032
27MP0010386_abnormal_urinary_bladder1.65600577
28MP0003787_abnormal_imprinting1.65570985
29MP0003880_abnormal_central_pattern1.63627175
30MP0001486_abnormal_startle_reflex1.56013459
31MP0003646_muscle_fatigue1.54771660
32MP0000383_abnormal_hair_follicle1.47736366
33MP0006276_abnormal_autonomic_nervous1.46730496
34MP0005174_abnormal_tail_pigmentation1.42525485
35MP0002064_seizures1.42411653
36MP0005084_abnormal_gallbladder_morpholo1.39501246
37MP0001501_abnormal_sleep_pattern1.37735679
38MP0002736_abnormal_nociception_after1.37610742
39MP0000631_abnormal_neuroendocrine_gland1.37187288
40MP0004742_abnormal_vestibular_system1.36939306
41MP0001485_abnormal_pinna_reflex1.30020708
42MP0002938_white_spotting1.25055242
43MP0002928_abnormal_bile_duct1.24494609
44MP0002572_abnormal_emotion/affect_behav1.22276745
45MP0002638_abnormal_pupillary_reflex1.22182721
46MP0003122_maternal_imprinting1.20730627
47MP0005389_reproductive_system_phenotype1.19885645
48MP0003011_delayed_dark_adaptation1.19047939
49MP0001970_abnormal_pain_threshold1.18807417
50MP0002160_abnormal_reproductive_system1.17870292
51MP0005310_abnormal_salivary_gland1.17662076
52MP0003136_yellow_coat_color1.14429049
53MP0001905_abnormal_dopamine_level1.13575707
54MP0002557_abnormal_social/conspecific_i1.13487606
55MP0000613_abnormal_salivary_gland1.12296821
56MP0001502_abnormal_circadian_rhythm1.09577219
57MP0002909_abnormal_adrenal_gland1.09049298
58MP0010329_abnormal_lipoprotein_level1.08895435
59MP0002735_abnormal_chemical_nociception1.06258261
60MP0001919_abnormal_reproductive_system1.06206995
61MP0005377_hearing/vestibular/ear_phenot1.06132914
62MP0003878_abnormal_ear_physiology1.06132914
63MP0004924_abnormal_behavior1.05493527
64MP0005386_behavior/neurological_phenoty1.05493527
65MP0002067_abnormal_sensory_capabilities1.05457641
66MP0002733_abnormal_thermal_nociception1.05064782
67MP0002653_abnormal_ependyma_morphology1.03661910
68MP0003635_abnormal_synaptic_transmissio1.02251738
69MP0004133_heterotaxia0.99875588
70MP0005195_abnormal_posterior_eye0.98134911
71MP0002734_abnormal_mechanical_nocicepti0.97916399
72MP0002693_abnormal_pancreas_physiology0.97544824
73MP0005332_abnormal_amino_acid0.95664689
74MP0009780_abnormal_chondrocyte_physiolo0.95510981
75MP0003283_abnormal_digestive_organ0.94392022
76MP0004215_abnormal_myocardial_fiber0.92907689
77MP0005167_abnormal_blood-brain_barrier0.91635127
78MP0002063_abnormal_learning/memory/cond0.91327942
79MP0005410_abnormal_fertilization0.91211291
80MP0000230_abnormal_systemic_arterial0.90998591
81MP0001324_abnormal_eye_pigmentation0.89668867
82MP0002229_neurodegeneration0.88997990
83MP0008995_early_reproductive_senescence0.88959761
84MP0002277_abnormal_respiratory_mucosa0.88577277
85MP0003252_abnormal_bile_duct0.87475415
86MP0005670_abnormal_white_adipose0.86461187
87MP0003718_maternal_effect0.86435402
88MP0000026_abnormal_inner_ear0.86178139
89MP0000647_abnormal_sebaceous_gland0.85463578
90MP0003698_abnormal_male_reproductive0.85362361
91MP0003121_genomic_imprinting0.85064454
92MP0001529_abnormal_vocalization0.84599940
93MP0008789_abnormal_olfactory_epithelium0.83089420
94MP0001764_abnormal_homeostasis0.82916176
95MP0001944_abnormal_pancreas_morphology0.82493275
96MP0006292_abnormal_olfactory_placode0.81865379
97MP0002752_abnormal_somatic_nervous0.81619563
98MP0002184_abnormal_innervation0.81205200
99MP0003137_abnormal_impulse_conducting0.80085502
100MP0000538_abnormal_urinary_bladder0.79270033

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.36884403
2Abnormality of midbrain morphology (HP:0002418)4.23423649
3Molar tooth sign on MRI (HP:0002419)4.23423649
4Congenital stationary night blindness (HP:0007642)3.99195267
5True hermaphroditism (HP:0010459)3.96824100
6Pancreatic fibrosis (HP:0100732)3.94934624
7Nephronophthisis (HP:0000090)3.40581308
8Type II lissencephaly (HP:0007260)3.40021078
9Hyperventilation (HP:0002883)3.24802827
10Abnormality of the renal cortex (HP:0011035)3.20814470
11Medial flaring of the eyebrow (HP:0010747)3.11245239
12Abnormal drinking behavior (HP:0030082)2.95686339
13Polydipsia (HP:0001959)2.95686339
14Abnormality of the renal medulla (HP:0100957)2.93963996
15Attenuation of retinal blood vessels (HP:0007843)2.93677617
16Abolished electroretinogram (ERG) (HP:0000550)2.76904774
17Large for gestational age (HP:0001520)2.73080598
18Cystic liver disease (HP:0006706)2.71681652
19Tubular atrophy (HP:0000092)2.65180015
20Polyuria (HP:0000103)2.56285925
21Pendular nystagmus (HP:0012043)2.55164276
22Lissencephaly (HP:0001339)2.55155548
23Chronic hepatic failure (HP:0100626)2.53715052
24Gaze-evoked nystagmus (HP:0000640)2.51284169
25Hemiparesis (HP:0001269)2.46006658
26Abnormal rod and cone electroretinograms (HP:0008323)2.44132171
27Absent speech (HP:0001344)2.42615277
28Inability to walk (HP:0002540)2.39632594
29Gait imbalance (HP:0002141)2.38673332
30Renal cortical cysts (HP:0000803)2.35965018
31Decreased central vision (HP:0007663)2.34927756
32Mitochondrial inheritance (HP:0001427)2.33245809
33Optic nerve hypoplasia (HP:0000609)2.33017350
34Congenital sensorineural hearing impairment (HP:0008527)2.32563744
35Cerebellar dysplasia (HP:0007033)2.31982843
36Congenital primary aphakia (HP:0007707)2.31723799
37Furrowed tongue (HP:0000221)2.30221571
38Increased CSF lactate (HP:0002490)2.29635785
39Febrile seizures (HP:0002373)2.26141755
40Acute necrotizing encephalopathy (HP:0006965)2.25700885
41Keratoconus (HP:0000563)2.25597902
42Increased corneal curvature (HP:0100692)2.25597902
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25056304
44Hepatic necrosis (HP:0002605)2.21637206
45Pachygyria (HP:0001302)2.19537030
46Progressive macrocephaly (HP:0004481)2.18677811
47Ketoacidosis (HP:0001993)2.16540491
48Nephrogenic diabetes insipidus (HP:0009806)2.13364445
49Bile duct proliferation (HP:0001408)2.12661471
50Abnormal biliary tract physiology (HP:0012439)2.12661471
51Tachypnea (HP:0002789)2.12561171
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12051183
53Abnormality of alanine metabolism (HP:0010916)2.12051183
54Hyperalaninemia (HP:0003348)2.12051183
55Hepatocellular necrosis (HP:0001404)2.10159472
56Broad-based gait (HP:0002136)2.09807866
57Severe muscular hypotonia (HP:0006829)2.09330745
58Genital tract atresia (HP:0001827)2.08915481
59Methylmalonic acidemia (HP:0002912)2.08803673
60Aplasia/Hypoplasia of the spleen (HP:0010451)2.07522486
61Hypomagnesemia (HP:0002917)2.06670250
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05796283
63Acute encephalopathy (HP:0006846)2.05741426
64Abnormal urine output (HP:0012590)2.05088394
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.02700728
66Abnormality of the labia minora (HP:0012880)2.02387531
67Hypothermia (HP:0002045)2.01468454
68Sclerocornea (HP:0000647)2.01083206
69Fair hair (HP:0002286)2.00077398
70Vaginal atresia (HP:0000148)1.99306426
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.97861298
72Bony spicule pigmentary retinopathy (HP:0007737)1.97816601
73Male pseudohermaphroditism (HP:0000037)1.97093245
74Neoplasm of the adrenal cortex (HP:0100641)1.96652093
75Congenital, generalized hypertrichosis (HP:0004540)1.96625174
76Progressive cerebellar ataxia (HP:0002073)1.95272689
77Decreased circulating renin level (HP:0003351)1.95187340
78Congenital hepatic fibrosis (HP:0002612)1.92367208
79Ketosis (HP:0001946)1.89622396
80Progressive inability to walk (HP:0002505)1.89453041
81Intestinal atresia (HP:0011100)1.88381186
82Abnormality of renal excretion (HP:0011036)1.86654235
83Polyphagia (HP:0002591)1.86592007
84Lipid accumulation in hepatocytes (HP:0006561)1.85789384
85Anencephaly (HP:0002323)1.84851838
86Hyperglycinuria (HP:0003108)1.82953265
87Dynein arm defect of respiratory motile cilia (HP:0012255)1.81721865
88Absent/shortened dynein arms (HP:0200106)1.81721865
89Agitation (HP:0000713)1.81516718
90Abnormal mitochondria in muscle tissue (HP:0008316)1.78147478
91Mesangial abnormality (HP:0001966)1.77684924
92Widely spaced teeth (HP:0000687)1.77367952
93Clumsiness (HP:0002312)1.77215391
94Abnormality of urine glucose concentration (HP:0011016)1.76606911
95Glycosuria (HP:0003076)1.76606911
96Small hand (HP:0200055)1.75716053
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75102968
98Aplasia/hypoplasia of the uterus (HP:0008684)1.74936992
99Stomach cancer (HP:0012126)1.74049521
100Methylmalonic aciduria (HP:0012120)1.73887071

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.18374547
2ADRBK23.71885673
3WNK33.24149399
4PINK12.99376599
5GRK12.76476038
6ZAK2.72920882
7CASK2.35906006
8WNK42.30086635
9MAP4K22.16861499
10NUAK12.09748370
11BRSK21.94535199
12TAOK31.94058561
13MAPK131.83693160
14CAMKK21.81326441
15BMPR1B1.77501802
16MAP3K41.70827861
17STK391.60378425
18DAPK21.59221268
19OXSR11.51633684
20TXK1.40231121
21TRIM281.38698956
22MUSK1.36222477
23DYRK21.30655680
24PAK31.24740244
25ACVR1B1.23040958
26MAPKAPK51.20102693
27INSRR1.18130771
28TLK11.17034019
29MARK11.11233862
30MAP2K71.10055258
31ADRBK11.08301712
32NEK21.07512090
33PRKCE1.07077699
34MST41.06748486
35TNIK1.06267594
36VRK21.01591858
37EPHA41.01055858
38WEE11.00717596
39FGFR21.00277460
40CSNK1G21.00136392
41PRKCG0.94674270
42CSNK1G10.94465754
43STK38L0.93582261
44MKNK20.92424060
45PNCK0.90935669
46NTRK30.90208338
47CSNK1G30.88222056
48MAPKAPK30.84734598
49PHKG10.83887902
50PHKG20.83887902
51PLK20.81850882
52VRK10.78677598
53GRK50.75223306
54CCNB10.72606486
55CSNK1A1L0.71693289
56PIK3CA0.66893901
57PTK2B0.65023996
58EPHB20.64510175
59CAMK10.63827719
60MAP2K60.62620747
61TSSK60.61087005
62FER0.60944737
63RPS6KA50.57340245
64CAMK2A0.56750769
65TAF10.56239640
66PLK30.55835881
67STK30.52844724
68IKBKB0.51989015
69CAMK1D0.51249013
70ERBB30.50914029
71BCR0.49946530
72CAMK1G0.48795632
73EPHA30.48205745
74TNK20.46843004
75PRKACA0.46394121
76PKN10.45049785
77IRAK10.44093538
78BCKDK0.44051655
79MAP2K40.42207147
80PRKCZ0.40419334
81NME10.40348417
82EIF2AK30.40117601
83PRKCI0.39852701
84TIE10.38977935
85CSNK1A10.38714533
86PRKCQ0.38676638
87CSNK1D0.36291560
88PRKCA0.36190737
89CAMK2D0.35332862
90CHUK0.34860401
91PRKG10.33741517
92HIPK20.32102054
93NTRK20.31842517
94BLK0.30752438
95TGFBR10.29506017
96NLK0.29158036
97NEK10.28849887
98PRKAA20.28542142
99LMTK20.28310178
100STK110.26372263

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.96512904
2Selenocompound metabolism_Homo sapiens_hsa004502.75999074
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.60355422
4Butanoate metabolism_Homo sapiens_hsa006502.59638777
5Linoleic acid metabolism_Homo sapiens_hsa005912.56963265
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54302246
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.45907602
8Nitrogen metabolism_Homo sapiens_hsa009102.44408071
9Oxidative phosphorylation_Homo sapiens_hsa001902.34183669
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.19806218
11Ether lipid metabolism_Homo sapiens_hsa005652.15116234
12Nicotine addiction_Homo sapiens_hsa050332.02691897
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02690116
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01332866
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.99636888
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95479304
17Protein export_Homo sapiens_hsa030601.90007507
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69497030
19Regulation of autophagy_Homo sapiens_hsa041401.67771366
20Tryptophan metabolism_Homo sapiens_hsa003801.65311234
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63232145
22Parkinsons disease_Homo sapiens_hsa050121.61525062
23Propanoate metabolism_Homo sapiens_hsa006401.56801630
24Caffeine metabolism_Homo sapiens_hsa002321.45994231
25Collecting duct acid secretion_Homo sapiens_hsa049661.35712034
26Peroxisome_Homo sapiens_hsa041461.34857757
27Insulin secretion_Homo sapiens_hsa049111.28858883
28Arachidonic acid metabolism_Homo sapiens_hsa005901.28012216
29Morphine addiction_Homo sapiens_hsa050321.25629820
30Homologous recombination_Homo sapiens_hsa034401.24722296
31Basal transcription factors_Homo sapiens_hsa030221.23693429
32Taste transduction_Homo sapiens_hsa047421.23280655
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.21793736
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20841914
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16830090
36RNA polymerase_Homo sapiens_hsa030201.12941528
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12223498
38Chemical carcinogenesis_Homo sapiens_hsa052041.05953411
39Olfactory transduction_Homo sapiens_hsa047401.03844804
40Ovarian steroidogenesis_Homo sapiens_hsa049131.01168627
41ABC transporters_Homo sapiens_hsa020100.99131917
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98350520
43Fanconi anemia pathway_Homo sapiens_hsa034600.98292421
44Huntingtons disease_Homo sapiens_hsa050160.96753691
45Cardiac muscle contraction_Homo sapiens_hsa042600.95043984
46GABAergic synapse_Homo sapiens_hsa047270.94765798
47Serotonergic synapse_Homo sapiens_hsa047260.94499829
48beta-Alanine metabolism_Homo sapiens_hsa004100.94346066
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92450992
50Circadian entrainment_Homo sapiens_hsa047130.92154042
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.91186466
52Mineral absorption_Homo sapiens_hsa049780.89252681
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86968144
54Proteasome_Homo sapiens_hsa030500.86736068
55Alzheimers disease_Homo sapiens_hsa050100.85117987
56Glutamatergic synapse_Homo sapiens_hsa047240.84466945
57Sulfur metabolism_Homo sapiens_hsa009200.83407917
58RNA degradation_Homo sapiens_hsa030180.83234372
59Fatty acid degradation_Homo sapiens_hsa000710.82981294
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82978953
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79122246
62Salivary secretion_Homo sapiens_hsa049700.78465372
63Retinol metabolism_Homo sapiens_hsa008300.78095866
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76214151
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76204180
66Fat digestion and absorption_Homo sapiens_hsa049750.75765997
67Histidine metabolism_Homo sapiens_hsa003400.75708924
68Calcium signaling pathway_Homo sapiens_hsa040200.72858431
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71431707
70One carbon pool by folate_Homo sapiens_hsa006700.71301843
71Metabolic pathways_Homo sapiens_hsa011000.65613816
72Glycerolipid metabolism_Homo sapiens_hsa005610.64185679
73Fatty acid elongation_Homo sapiens_hsa000620.62432445
74Fatty acid metabolism_Homo sapiens_hsa012120.62108569
75Synaptic vesicle cycle_Homo sapiens_hsa047210.62004001
76Sphingolipid metabolism_Homo sapiens_hsa006000.59764085
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57452864
78Type I diabetes mellitus_Homo sapiens_hsa049400.57055403
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55475858
80Purine metabolism_Homo sapiens_hsa002300.54535634
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50853706
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.49692039
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49591345
84Rheumatoid arthritis_Homo sapiens_hsa053230.48268245
85Glutathione metabolism_Homo sapiens_hsa004800.47414328
86Circadian rhythm_Homo sapiens_hsa047100.44778320
87Dopaminergic synapse_Homo sapiens_hsa047280.43940275
88Vitamin digestion and absorption_Homo sapiens_hsa049770.42278896
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42028742
90cAMP signaling pathway_Homo sapiens_hsa040240.41241051
91Cocaine addiction_Homo sapiens_hsa050300.40025365
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39152965
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.38324677
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37507395
95Fatty acid biosynthesis_Homo sapiens_hsa000610.34545769
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.33716092
97Steroid biosynthesis_Homo sapiens_hsa001000.32697225
98Dorso-ventral axis formation_Homo sapiens_hsa043200.32696056
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.31398537
100Amphetamine addiction_Homo sapiens_hsa050310.30656129

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