GDF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gonadotropin secretion (GO:0032276)6.34032967
2regulation of cardioblast differentiation (GO:0051890)5.91200397
3chondrocyte proliferation (GO:0035988)5.88959743
4* spinal cord association neuron differentiation (GO:0021527)5.67927995
5hematopoietic stem cell proliferation (GO:0071425)5.42679016
6mannose metabolic process (GO:0006013)5.42510108
7positive regulation of gastrulation (GO:2000543)5.34483423
8negative regulation of axon extension involved in axon guidance (GO:0048843)5.18014296
9ectodermal placode formation (GO:0060788)5.12470410
10branching involved in prostate gland morphogenesis (GO:0060442)4.86696332
11negative regulation of fibrinolysis (GO:0051918)4.86635136
12somite development (GO:0061053)4.67437574
13innervation (GO:0060384)4.56159945
14positive regulation of cardiac muscle cell differentiation (GO:2000727)4.49473972
15negative regulation of axon guidance (GO:1902668)4.46736067
16regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.45659792
17negative regulation of cell fate specification (GO:0009996)4.43862919
18cytoskeletal anchoring at plasma membrane (GO:0007016)4.42887315
19lateral sprouting from an epithelium (GO:0060601)4.42259162
20prostate gland epithelium morphogenesis (GO:0060740)4.20296300
21positive regulation of chondrocyte differentiation (GO:0032332)4.19867736
22positive regulation of embryonic development (GO:0040019)4.18464602
23regulation of fibrinolysis (GO:0051917)4.07625353
24epithelial cell differentiation involved in prostate gland development (GO:0060742)4.03095958
25regulation of plasminogen activation (GO:0010755)4.01446772
26insulin-like growth factor receptor signaling pathway (GO:0048009)3.95747675
27auditory behavior (GO:0031223)3.94822863
28regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.93624927
29cell proliferation in forebrain (GO:0021846)3.88512732
30post-anal tail morphogenesis (GO:0036342)3.81269977
31neuron fate determination (GO:0048664)3.79406323
32embryonic digestive tract morphogenesis (GO:0048557)3.77549834
33regulation of axon extension involved in axon guidance (GO:0048841)3.76991903
34anterior/posterior axis specification, embryo (GO:0008595)3.76321178
35cell surface receptor signaling pathway involved in heart development (GO:0061311)3.75526699
36polarized epithelial cell differentiation (GO:0030859)3.75184108
37negative regulation of T cell differentiation in thymus (GO:0033085)3.67935224
38regulation of non-canonical Wnt signaling pathway (GO:2000050)3.67584997
39ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.66251243
40collecting duct development (GO:0072044)3.62848839
41negative regulation of alpha-beta T cell differentiation (GO:0046639)3.62388092
42mesenchymal-epithelial cell signaling (GO:0060638)3.61772897
43lung epithelium development (GO:0060428)3.53727435
44cornea development in camera-type eye (GO:0061303)3.53724198
45* midbrain development (GO:0030901)3.51239860
46dorsal/ventral neural tube patterning (GO:0021904)3.47786174
47apoptotic cell clearance (GO:0043277)3.47467605
48regulation of axon guidance (GO:1902667)3.47461566
49regulation of sister chromatid cohesion (GO:0007063)3.43764705
50artery smooth muscle contraction (GO:0014824)3.43484320
51prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.42430050
52ectoderm development (GO:0007398)3.42293875
53hippo signaling (GO:0035329)3.41246059
54activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.39143806
55sex determination (GO:0007530)3.37862077
56cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.37763924
57endocardial cushion development (GO:0003197)3.36616584
58tonic smooth muscle contraction (GO:0014820)3.36589838
59regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.36033620
60extracellular matrix assembly (GO:0085029)3.35311042
61establishment of apical/basal cell polarity (GO:0035089)3.35282949
62positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.35184855
63regulation of heart morphogenesis (GO:2000826)3.32041899
64otic vesicle formation (GO:0030916)3.31887816
65artery development (GO:0060840)3.29855268
66positive regulation of cartilage development (GO:0061036)3.27248833
67branching involved in salivary gland morphogenesis (GO:0060445)3.24835728
68N-glycan processing (GO:0006491)3.24600396
69regulation of collateral sprouting (GO:0048670)3.24150549
70prostate gland growth (GO:0060736)3.21174209
71protein localization to cell surface (GO:0034394)3.19361212
72axis elongation (GO:0003401)3.19293900
73heart valve formation (GO:0003188)3.17851959
74dorsal/ventral axis specification (GO:0009950)3.17830506
75positive regulation of catenin import into nucleus (GO:0035413)3.17644318
76positive regulation of nuclease activity (GO:0032075)3.17569127
77regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.15392335
78regulation of mesoderm development (GO:2000380)3.15134915
79regulation of translational fidelity (GO:0006450)3.14396927
80positive regulation of collagen biosynthetic process (GO:0032967)3.11062938
81patterning of blood vessels (GO:0001569)3.08516193
82fibroblast migration (GO:0010761)3.08171719
83negative regulation of adherens junction organization (GO:1903392)3.07090964
84negative regulation of focal adhesion assembly (GO:0051895)3.07090964
85negative regulation of cell junction assembly (GO:1901889)3.07090964
86collagen fibril organization (GO:0030199)3.05346100
87cellular response to leptin stimulus (GO:0044320)3.02114358
88positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.02043498
89regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.99159539
90nephron tubule formation (GO:0072079)2.99056298
91lung lobe morphogenesis (GO:0060463)2.97293255
92limb bud formation (GO:0060174)2.96759809
93positive regulation of canonical Wnt signaling pathway (GO:0090263)2.94493665
94wound healing, spreading of epidermal cells (GO:0035313)2.94141753
95male genitalia development (GO:0030539)2.93639036
96endothelial cell morphogenesis (GO:0001886)2.93220018
97embryonic foregut morphogenesis (GO:0048617)2.93020481
98cranial suture morphogenesis (GO:0060363)2.92760335
99paraxial mesoderm development (GO:0048339)2.92177717
100positive regulation of endothelial cell differentiation (GO:0045603)2.91980777
101lymphangiogenesis (GO:0001946)2.91883629
102establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.91617098
103positive regulation of natural killer cell differentiation (GO:0032825)2.91123924
104response to auditory stimulus (GO:0010996)2.90430099
105endocardial cushion morphogenesis (GO:0003203)2.89914964
106peptidyl-glutamic acid carboxylation (GO:0017187)2.89091724
107protein carboxylation (GO:0018214)2.89091724
108regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.88690939
109positive regulation of collagen metabolic process (GO:0010714)2.88429945
110creatine metabolic process (GO:0006600)2.87575830
111mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.87290681
112positive regulation of smoothened signaling pathway (GO:0045880)2.86944512
113establishment of monopolar cell polarity (GO:0061162)2.86827600
114establishment or maintenance of monopolar cell polarity (GO:0061339)2.86827600
115mammary gland development (GO:0030879)2.86721579
116positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.86331009
117cell fate commitment involved in formation of primary germ layer (GO:0060795)2.85407540
118embryonic retina morphogenesis in camera-type eye (GO:0060059)2.85352054
119adherens junction assembly (GO:0034333)2.84761157
120endothelium development (GO:0003158)2.84641996
121planar cell polarity pathway involved in neural tube closure (GO:0090179)2.82963816
122embryonic camera-type eye morphogenesis (GO:0048596)2.82380929
123lung-associated mesenchyme development (GO:0060484)2.82284619
124mesenchymal cell proliferation (GO:0010463)2.80022700
125gap junction assembly (GO:0016264)2.79455769
126skin morphogenesis (GO:0043589)2.79436031
127regulation of nuclease activity (GO:0032069)2.79063927
128endoplasmic reticulum unfolded protein response (GO:0030968)2.78889068
129embryonic skeletal joint morphogenesis (GO:0060272)2.77949563
130regulation of catenin import into nucleus (GO:0035412)2.77609219
131hepatocyte differentiation (GO:0070365)2.76491345
132hemidesmosome assembly (GO:0031581)2.76228751
133cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.76161915
134mesenchyme morphogenesis (GO:0072132)2.74479707
135cellular response to interferon-alpha (GO:0035457)2.74233374
136lymph vessel development (GO:0001945)2.73773002
137negative regulation of cell fate commitment (GO:0010454)2.73485369
138heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.73293963
139oocyte development (GO:0048599)2.73214378
140positive regulation of cardiac muscle tissue development (GO:0055025)2.72331621
141Golgi transport vesicle coating (GO:0048200)2.71689602
142COPI coating of Golgi vesicle (GO:0048205)2.71689602
143regulation of protein activation cascade (GO:2000257)2.70233474
144cell morphogenesis involved in neuron differentiation (GO:0048667)2.69931601
145positive regulation of BMP signaling pathway (GO:0030513)2.69906924
146embryonic placenta development (GO:0001892)2.69608288
147regulation of chondrocyte differentiation (GO:0032330)2.69215587
148heart looping (GO:0001947)2.68749220
149cellular response to unfolded protein (GO:0034620)2.67917337
150embryonic eye morphogenesis (GO:0048048)2.67757499
151regulation of cardiac muscle cell differentiation (GO:2000725)2.67754404
152* activin receptor signaling pathway (GO:0032924)2.66798368
153collagen metabolic process (GO:0032963)2.65395218
154embryonic heart tube morphogenesis (GO:0003143)2.65167250
155retina vasculature morphogenesis in camera-type eye (GO:0061299)2.65025262
156potassium ion homeostasis (GO:0055075)2.64725191
157negative regulation of chondrocyte differentiation (GO:0032331)2.64396486
158ER-nucleus signaling pathway (GO:0006984)2.63610642
159cellular response to vitamin (GO:0071295)2.63377163
160multicellular organismal macromolecule metabolic process (GO:0044259)2.60685716
161regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.60407867
162positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.60041607
163collagen catabolic process (GO:0030574)2.59923168
164neuromuscular junction development (GO:0007528)2.59769734
165regulation of complement activation (GO:0030449)2.59241477
166gastrulation with mouth forming second (GO:0001702)2.59062128
167drinking behavior (GO:0042756)2.58930430
168midgut development (GO:0007494)2.58890988
169positive regulation of cardiac muscle hypertrophy (GO:0010613)2.58698614
170positive regulation of muscle hypertrophy (GO:0014742)2.58698614
171organ induction (GO:0001759)2.58566133
172tongue development (GO:0043586)2.58440303
173endodermal cell differentiation (GO:0035987)2.58360636
174hormone catabolic process (GO:0042447)2.58290075
175sulfur amino acid catabolic process (GO:0000098)2.55407504
176branching involved in mammary gland duct morphogenesis (GO:0060444)2.54472994
177cellular response to prostaglandin stimulus (GO:0071379)2.53830006
178epithelial cell-cell adhesion (GO:0090136)2.53611699
179negative regulation of DNA repair (GO:0045738)2.50769025
180placenta blood vessel development (GO:0060674)2.50369808
181vitamin transmembrane transport (GO:0035461)2.49373732
182cellular senescence (GO:0090398)2.48765815
183regulation of mitotic spindle organization (GO:0060236)2.48159580
184sequestering of extracellular ligand from receptor (GO:0035581)2.47532131
185cellular response to vitamin D (GO:0071305)2.47111316
186regulation of SMAD protein import into nucleus (GO:0060390)2.47064224
187extracellular matrix disassembly (GO:0022617)2.46705644
188synaptic vesicle docking involved in exocytosis (GO:0016081)2.46179455
189protein heterotrimerization (GO:0070208)2.45331991
190regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45288483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.20695107
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.01488608
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.98646414
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.41054728
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.17863425
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.17863425
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.17863425
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.15627245
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.03161195
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.77139777
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.57728722
12CLOCK_20551151_ChIP-Seq_293T_Human2.39012362
13* CBX2_27304074_Chip-Seq_ESCs_Mouse2.31989043
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.28138148
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26014437
16* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.24870226
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.21204916
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19661531
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19539830
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16062253
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.14071660
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09405587
23* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07636809
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05901289
25* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00461573
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.95436191
27ZNF263_19887448_ChIP-Seq_K562_Human1.94107745
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93886789
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.92392526
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.91488919
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91013033
32* EZH2_27294783_Chip-Seq_ESCs_Mouse1.90995627
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.88847594
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86792996
35GATA1_22025678_ChIP-Seq_K562_Human1.86430136
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.82139471
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78990070
38RNF2_27304074_Chip-Seq_NSC_Mouse1.78502659
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.77489736
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74496159
41TP53_16413492_ChIP-PET_HCT116_Human1.72709608
42* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67815114
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.67579685
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.66139072
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65114518
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62928338
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61962068
48KDM2B_26808549_Chip-Seq_K562_Human1.56936503
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56802862
50IGF1R_20145208_ChIP-Seq_DFB_Human1.55824073
51* TP53_20018659_ChIP-ChIP_R1E_Mouse1.54978876
52* RING1B_27294783_Chip-Seq_ESCs_Mouse1.54765443
53AHR_22903824_ChIP-Seq_MCF-7_Human1.52098694
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50163399
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49873753
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44833495
57* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44047015
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41997654
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40980187
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40815750
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40708261
62* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40415327
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40307412
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39071573
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.39066139
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.39043561
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38870413
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38267635
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38190404
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38190404
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37091518
72* EED_16625203_ChIP-ChIP_MESCs_Mouse1.36574577
73ATF3_27146783_Chip-Seq_COLON_Human1.36340884
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.35922211
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.34951793
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.34944809
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33304572
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32813250
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32629618
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.32024728
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.31064790
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30764856
83* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30485822
84CJUN_26792858_Chip-Seq_BT549_Human1.30015212
85* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29966931
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29910409
87RACK7_27058665_Chip-Seq_MCF-7_Human1.28411942
88GBX2_23144817_ChIP-Seq_PC3_Human1.26275562
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26095907
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25682677
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.25147920
92TP63_17297297_ChIP-ChIP_HaCaT_Human1.24572778
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23743521
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23586080
95TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23257649
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22017397
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.21178939
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20900384
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20732947
100* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20496603
101* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20496603
102* RNF2_27304074_Chip-Seq_ESCs_Mouse1.19884290
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18940045
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.18657220
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.18286090
106VDR_22108803_ChIP-Seq_LS180_Human1.18267364
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18107561
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18107561
109BRD4_25478319_ChIP-Seq_HGPS_Human1.17305336
110FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17113474
111CREB1_26743006_Chip-Seq_LNCaP_Human1.16592251
112* EZH2_27304074_Chip-Seq_ESCs_Mouse1.16547752
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14677219
114KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14521217
115PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14364505
116ESR1_21235772_ChIP-Seq_MCF-7_Human1.14158516
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13976236
118KDM2B_26808549_Chip-Seq_JURKAT_Human1.13598907
119EGR1_19374776_ChIP-ChIP_THP-1_Human1.12905884
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12838382
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12209184
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11412246
123FUS_26573619_Chip-Seq_HEK293_Human1.11276695
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09287616
125SOX2_20726797_ChIP-Seq_SW620_Human1.08838687
126CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07999491
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07416744
128* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07298053
129* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07165787
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06816762
131RXR_22108803_ChIP-Seq_LS180_Human1.06529186
132CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05436949
133P300_19829295_ChIP-Seq_ESCs_Human1.05319012
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04913121
135PIAS1_25552417_ChIP-Seq_VCAP_Human1.04756612
136KDM2B_26808549_Chip-Seq_DND41_Human1.04294904
137SMAD3_21741376_ChIP-Seq_HESCs_Human1.04269425
138FOXA2_19822575_ChIP-Seq_HepG2_Human1.04139234
139AR_21572438_ChIP-Seq_LNCaP_Human1.03920741
140TP53_22127205_ChIP-Seq_IMR90_Human1.03480775
141IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02198865
142DROSHA_22980978_ChIP-Seq_HELA_Human1.01845399
143* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01470190
144NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01458735
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01063662
146AR_21909140_ChIP-Seq_LNCAP_Human1.01050958
147AR_19668381_ChIP-Seq_PC3_Human1.00653441
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00364646
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99900422
150EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97443422
151* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96970017
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.96923008
153RXR_22158963_ChIP-Seq_LIVER_Mouse0.96921369
154POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96051858
155SMAD4_21799915_ChIP-Seq_A2780_Human0.95904047
156BCAT_22108803_ChIP-Seq_LS180_Human0.92921016
157RUNX2_22187159_ChIP-Seq_PCA_Human0.92391904
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91844658
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91019358
160POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91019358
161STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89294284
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89216166
163PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87076357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.09358202
2MP0008438_abnormal_cutaneous_collagen5.18280014
3MP0010234_abnormal_vibrissa_follicle4.02501184
4MP0003705_abnormal_hypodermis_morpholog3.54283500
5MP0005623_abnormal_meninges_morphology3.44912409
6MP0000537_abnormal_urethra_morphology3.40258322
7MP0010368_abnormal_lymphatic_system3.29357841
8MP0003195_calcinosis2.77676646
9MP0003279_aneurysm2.63776678
10MP0006054_spinal_hemorrhage2.46119108
11MP0005275_abnormal_skin_tensile2.42665298
12MP0010030_abnormal_orbit_morphology2.42178295
13MP0001958_emphysema2.34579494
14MP0000049_abnormal_middle_ear2.32365868
15MP0005248_abnormal_Harderian_gland2.21016183
16MP0002938_white_spotting2.20382812
17MP0006292_abnormal_olfactory_placode2.20054395
18MP0003045_fibrosis2.17335890
19MP0002090_abnormal_vision2.15136685
20MP0004272_abnormal_basement_membrane2.10078311
21MP0003938_abnormal_ear_development2.08114125
22MP0005503_abnormal_tendon_morphology2.05588006
23MP0000534_abnormal_ureter_morphology2.05035846
24MP0004858_abnormal_nervous_system1.89110075
25MP0000733_abnormal_muscle_development1.88070998
26MP0001661_extended_life_span1.85800557
27MP0005257_abnormal_intraocular_pressure1.83269480
28MP0003315_abnormal_perineum_morphology1.79049636
29MP0005076_abnormal_cell_differentiation1.78122766
30MP0001299_abnormal_eye_distance/1.73796785
31MP0003136_yellow_coat_color1.65980525
32MP0003091_abnormal_cell_migration1.65444380
33MP0010352_gastrointestinal_tract_polyps1.65335343
34MP0002138_abnormal_hepatobiliary_system1.61299933
35MP0003122_maternal_imprinting1.60585503
36MP0009384_cardiac_valve_regurgitation1.59914943
37MP0004233_abnormal_muscle_weight1.59897103
38MP0005220_abnormal_exocrine_pancreas1.54687857
39MP0003942_abnormal_urinary_system1.54311019
40MP0003385_abnormal_body_wall1.53926924
41MP0005508_abnormal_skeleton_morphology1.53897449
42MP0005171_absent_coat_pigmentation1.53013015
43MP0002896_abnormal_bone_mineralization1.51979336
44MP0000462_abnormal_digestive_system1.48577118
45MP0003300_gastrointestinal_ulcer1.45858333
46MP0003755_abnormal_palate_morphology1.42942719
47MP0001293_anophthalmia1.41625936
48MP0005085_abnormal_gallbladder_physiolo1.41295587
49MP0003937_abnormal_limbs/digits/tail_de1.40813076
50MP0002139_abnormal_hepatobiliary_system1.40595782
51MP0009780_abnormal_chondrocyte_physiolo1.38435727
52MP0001346_abnormal_lacrimal_gland1.37323484
53MP0006072_abnormal_retinal_apoptosis1.36864000
54MP0010678_abnormal_skin_adnexa1.36804076
55MP0001879_abnormal_lymphatic_vessel1.33984129
56MP0002160_abnormal_reproductive_system1.32737489
57MP0008875_abnormal_xenobiotic_pharmacok1.32065000
58MP0004145_abnormal_muscle_electrophysio1.31366779
59MP0002233_abnormal_nose_morphology1.31172935
60MP0002932_abnormal_joint_morphology1.30824266
61MP0002060_abnormal_skin_morphology1.29941225
62MP0003566_abnormal_cell_adhesion1.29770082
63MP0003935_abnormal_craniofacial_develop1.29158848
64MP0000767_abnormal_smooth_muscle1.28374224
65MP0003632_abnormal_nervous_system1.28364846
66MP0003941_abnormal_skin_development1.23130144
67MP0005023_abnormal_wound_healing1.21214145
68MP0000026_abnormal_inner_ear1.20299057
69MP0002166_altered_tumor_susceptibility1.20280716
70MP0005187_abnormal_penis_morphology1.17490741
71MP0002127_abnormal_cardiovascular_syste1.12584929
72MP0009250_abnormal_appendicular_skeleto1.11321453
73MP0000613_abnormal_salivary_gland1.09402922
74MP0000428_abnormal_craniofacial_morphol1.08918806
75MP0003283_abnormal_digestive_organ1.08021586
76MP0008961_abnormal_basal_metabolism1.06485348
77MP0009053_abnormal_anal_canal1.04913095
78MP0002108_abnormal_muscle_morphology1.01054697
79MP0002092_abnormal_eye_morphology1.00558804
80MP0003115_abnormal_respiratory_system1.00199192
81MP0005551_abnormal_eye_electrophysiolog0.99075789
82MP0005360_urolithiasis0.98921079
83MP0000432_abnormal_head_morphology0.98463985
84MP0002697_abnormal_eye_size0.96935593
85MP0000751_myopathy0.96536778
86MP0002111_abnormal_tail_morphology0.94709079
87MP0002115_abnormal_skeleton_extremities0.94671303
88MP0000762_abnormal_tongue_morphology0.94383823
89MP0005367_renal/urinary_system_phenotyp0.93807754
90MP0000516_abnormal_urinary_system0.93807754
91MP0000631_abnormal_neuroendocrine_gland0.93683318
92MP0002295_abnormal_pulmonary_circulatio0.92951656
93MP0000778_abnormal_nervous_system0.92695088
94MP0005365_abnormal_bile_salt0.92362334
95MP0006276_abnormal_autonomic_nervous0.92007299
96MP0002114_abnormal_axial_skeleton0.91793050
97MP0001286_abnormal_eye_development0.91585292
98MP0001666_abnormal_nutrient_absorption0.90563262
99MP0002933_joint_inflammation0.90076257
100MP0005408_hypopigmentation0.89951418
101MP0009278_abnormal_bone_marrow0.89758675
102MP0000163_abnormal_cartilage_morphology0.89575162
103MP0002109_abnormal_limb_morphology0.88204036
104MP0003121_genomic_imprinting0.87595866
105MP0008995_early_reproductive_senescence0.87193825
106MP0004142_abnormal_muscle_tone0.86339078
107MP0002282_abnormal_trachea_morphology0.85721691
108MP0001324_abnormal_eye_pigmentation0.84470885
109MP0001915_intracranial_hemorrhage0.83937120
110MP0002128_abnormal_blood_circulation0.83479875
111MP0010307_abnormal_tumor_latency0.83266844
112MP0002009_preneoplasia0.82989127
113MP0001177_atelectasis0.82662732
114MP0005058_abnormal_lysosome_morphology0.82541505
115MP0002249_abnormal_larynx_morphology0.82430862
116MP0002168_other_aberrant_phenotype0.82138363
117MP0000003_abnormal_adipose_tissue0.81082524
118MP0003890_abnormal_embryonic-extraembry0.80145248
119MP0004134_abnormal_chest_morphology0.79111013
120MP0002925_abnormal_cardiovascular_devel0.77684058
121MP0002116_abnormal_craniofacial_bone0.77020858
122MP0009697_abnormal_copulation0.75887024
123MP0000750_abnormal_muscle_regeneration0.74667388
124* MP0002085_abnormal_embryonic_tissue0.74093883
125MP0001765_abnormal_ion_homeostasis0.73656396
126MP0001614_abnormal_blood_vessel0.73270907
127MP0005390_skeleton_phenotype0.72609562
128MP0005197_abnormal_uvea_morphology0.72581938
129MP0002184_abnormal_innervation0.72362726
130MP0005310_abnormal_salivary_gland0.72018186
131MP0010329_abnormal_lipoprotein_level0.71818690
132MP0001756_abnormal_urination0.71203811
133MP0003936_abnormal_reproductive_system0.70198067
134MP0003011_delayed_dark_adaptation0.69979239
135MP0001340_abnormal_eyelid_morphology0.69757769
136MP0002928_abnormal_bile_duct0.69677787
137MP0002269_muscular_atrophy0.68729954
138MP0002113_abnormal_skeleton_development0.68666783
139MP0005389_reproductive_system_phenotype0.68133595
140MP0008004_abnormal_stomach_pH0.68095478
141MP0005391_vision/eye_phenotype0.68059443
142MP0000538_abnormal_urinary_bladder0.68003712
143MP0002084_abnormal_developmental_patter0.67654290
144MP0004043_abnormal_pH_regulation0.67433024
145MP0003119_abnormal_digestive_system0.67384770
146MP0010386_abnormal_urinary_bladder0.67373373
147MP0000013_abnormal_adipose_tissue0.67366153
148MP0002006_tumorigenesis0.66799397
149MP0000627_abnormal_mammary_gland0.66390951
150MP0002089_abnormal_postnatal_growth/wei0.65908509

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.96294044
2Vitreoretinal degeneration (HP:0000655)4.75392265
3Aortic aneurysm (HP:0004942)4.52803422
4Ankle contracture (HP:0006466)4.50010863
5Abnormality of the distal phalanx of the thumb (HP:0009617)4.48170789
6Stenosis of the external auditory canal (HP:0000402)4.36779687
7Cerebral aneurysm (HP:0004944)4.27092499
8Abnormality of the middle phalanges of the toes (HP:0010183)4.26759012
9Shallow orbits (HP:0000586)4.09097453
10Aortic dissection (HP:0002647)4.06009584
11Protrusio acetabuli (HP:0003179)3.97326499
12Abnormality of the proximal phalanges of the hand (HP:0009834)3.91305865
13Abnormality of the phalanges of the hallux (HP:0010057)3.62082097
14Shawl scrotum (HP:0000049)3.44946893
15Gonadal dysgenesis (HP:0000133)3.36098743
16Cupped ribs (HP:0000887)3.33769260
17Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.33252771
18Hypoplasia of the ulna (HP:0003022)3.23003892
19Bowel diverticulosis (HP:0005222)3.14513381
20Gonadotropin excess (HP:0000837)3.14431040
21Deep venous thrombosis (HP:0002625)3.13024341
22Partial duplication of thumb phalanx (HP:0009944)3.08419889
23Aplasia/Hypoplasia of the hallux (HP:0008362)3.08390801
24Osteomalacia (HP:0002749)3.07027109
25Flared iliac wings (HP:0002869)3.06503070
26Ulnar bowing (HP:0003031)2.95273850
27Broad palm (HP:0001169)2.93575964
28Subacute progressive viral hepatitis (HP:0006572)2.90003868
29Symphalangism affecting the phalanges of the hand (HP:0009773)2.88776404
30Aneurysm (HP:0002617)2.85829035
31Abnormality of the 1st metacarpal (HP:0010009)2.84999984
32Wrist flexion contracture (HP:0001239)2.80383798
33Bladder diverticulum (HP:0000015)2.76769767
34Short tibia (HP:0005736)2.72077622
35Dilatation of the ascending aorta (HP:0005111)2.69801008
36Abnormality of carpal bone ossification (HP:0006257)2.69616057
37Coronal craniosynostosis (HP:0004440)2.68630237
38Cutaneous finger syndactyly (HP:0010554)2.67795326
39Atrophic scars (HP:0001075)2.64431666
40Abnormality of incisor morphology (HP:0011063)2.64322598
41Aplasia/Hypoplasia of the ulna (HP:0006495)2.62862811
42Partial duplication of the phalanx of hand (HP:0009999)2.62774789
43Aplasia involving bones of the extremities (HP:0009825)2.62137054
44Aplasia involving bones of the upper limbs (HP:0009823)2.62137054
45Aplasia of the phalanges of the hand (HP:0009802)2.62137054
46Fragile skin (HP:0001030)2.61732367
47Camptodactyly of toe (HP:0001836)2.61337110
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.59496232
49Increased connective tissue (HP:0009025)2.59475307
50Short middle phalanx of finger (HP:0005819)2.58995084
51Round ear (HP:0100830)2.58019229
52Vertebral clefting (HP:0008428)2.51569045
53Cutaneous syndactyly (HP:0012725)2.48150709
54Difficulty climbing stairs (HP:0003551)2.47800411
55Absent phalangeal crease (HP:0006109)2.42275558
56Long toe (HP:0010511)2.42045307
57Short phalanx of the thumb (HP:0009660)2.39118833
58Synostosis of carpal bones (HP:0005048)2.38407198
59Cervical subluxation (HP:0003308)2.37598527
60Broad metatarsal (HP:0001783)2.37575282
61Spastic diplegia (HP:0001264)2.36290103
62Limited hip movement (HP:0008800)2.35332351
63Short clavicles (HP:0000894)2.34472541
64Mixed hearing impairment (HP:0000410)2.32950692
65Mitral valve prolapse (HP:0001634)2.32699789
66Abnormal ossification of hand bones (HP:0005921)2.31524851
67Short humerus (HP:0005792)2.29657932
68Preaxial foot polydactyly (HP:0001841)2.28246105
69Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.26070892
70Abnormality of the phalanges of the 2nd finger (HP:0009541)2.23769119
71Turricephaly (HP:0000262)2.21820588
72Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.21761616
73Abnormal hand bone ossification (HP:0010660)2.21552812
74Prolonged partial thromboplastin time (HP:0003645)2.21544923
75Short nail (HP:0001799)2.20979480
76Mildly elevated creatine phosphokinase (HP:0008180)2.20000614
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.19489644
78Osteolytic defects of the hand bones (HP:0009699)2.19489644
79Hypoplasia of the iris (HP:0007676)2.19077902
80Scapular winging (HP:0003691)2.16596285
81Synostosis involving bones of the hand (HP:0004278)2.16441983
82Rectal prolapse (HP:0002035)2.15395708
83Upper limb amyotrophy (HP:0009129)2.14312599
84Distal upper limb amyotrophy (HP:0007149)2.14312599
85Epiphyseal dysplasia (HP:0002656)2.14290562
86Abnormal sex determination (HP:0012244)2.13968604
87Sex reversal (HP:0012245)2.13968604
88Limited elbow extension (HP:0001377)2.13955530
89Wormian bones (HP:0002645)2.13442559
90Hypoplasia of the radius (HP:0002984)2.12914859
91Increased density of long bones (HP:0006392)2.12552088
92Irregular epiphyses (HP:0010582)2.11864173
93Arterial tortuosity (HP:0005116)2.11756811
94Soft skin (HP:0000977)2.11005319
95Vascular tortuosity (HP:0004948)2.10287878
96Hip contracture (HP:0003273)2.10166505
97Trigonocephaly (HP:0000243)2.09372343
98Coxa vara (HP:0002812)2.09195706
99Aplasia/Hypoplasia of the clavicles (HP:0006710)2.09106671
100Hyperacusis (HP:0010780)2.09089514
101Radial bowing (HP:0002986)2.08813167
102Deviation of the hallux (HP:0010051)2.08777381
103Abnormality of the fibula (HP:0002991)2.08187839
104Arthropathy (HP:0003040)2.07029364
105Short femoral neck (HP:0100864)2.06802792
106Ovoid vertebral bodies (HP:0003300)2.06126892
107Sparse lateral eyebrow (HP:0005338)2.04619772
108Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.03888694
109Buphthalmos (HP:0000557)2.02917243
110Aplasia/hypoplasia of the humerus (HP:0006507)2.02412569
111Tracheomalacia (HP:0002779)2.01414163
112Duplication of thumb phalanx (HP:0009942)2.00762052
113Bowed forearm bones (HP:0003956)1.99537394
114Bowing of the arm (HP:0006488)1.99537394
115Hypoplastic ilia (HP:0000946)1.99345873
116Renal duplication (HP:0000075)1.99336190
117Renovascular hypertension (HP:0100817)1.97639102
118Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.97150107
119Broad thumb (HP:0011304)1.96395783
120Selective tooth agenesis (HP:0001592)1.96048564
121Capillary hemangiomas (HP:0005306)1.95621973
122Hypoplastic iliac wings (HP:0002866)1.94947954
123Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.94870174
124Abnormality of femoral epiphyses (HP:0006499)1.94870174
125Infantile muscular hypotonia (HP:0008947)1.94752190
126Complement deficiency (HP:0004431)1.94404235
127Alacrima (HP:0000522)1.93321181
128Broad distal phalanx of finger (HP:0009836)1.92466865
129Hallux valgus (HP:0001822)1.92070789
130Abnormal finger flexion creases (HP:0006143)1.91741200
131Visceral angiomatosis (HP:0100761)1.91367796
132Disproportionate tall stature (HP:0001519)1.90647337
133Abnormality of the umbilical cord (HP:0010881)1.90414215
134Forearm undergrowth (HP:0009821)1.89835924
135Joint contractures involving the joints of the feet (HP:0100492)1.89824990
136Flexion contracture of toe (HP:0005830)1.89824990
137Hemangiomatosis (HP:0007461)1.89360094
138Thin ribs (HP:0000883)1.87931325
139Macroorchidism (HP:0000053)1.86901444
140Knee flexion contracture (HP:0006380)1.86550414
141Carpal synostosis (HP:0009702)1.85241430
142Premature skin wrinkling (HP:0100678)1.84844003
143Type 1 muscle fiber predominance (HP:0003803)1.84693475
144Lumbar hyperlordosis (HP:0002938)1.84074659
145Short hallux (HP:0010109)1.82750167
146Hypoplastic ischia (HP:0003175)1.82309261
147Joint hemorrhage (HP:0005261)1.81904890
148Broad alveolar ridges (HP:0000187)1.81853338
149Flat cornea (HP:0007720)1.81378731
150Abnormality of the 2nd finger (HP:0004100)1.81154359
151Aplasia/hypoplasia of the femur (HP:0005613)1.79803807
152Broad ribs (HP:0000885)1.79607139
153Absent radius (HP:0003974)1.77352719
154Humeroradial synostosis (HP:0003041)1.77262816
155Severe Myopia (HP:0011003)1.77019395
156Enlarged penis (HP:0000040)1.76315485
157Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75827509
158Short 4th metacarpal (HP:0010044)1.75827509
159Aortic regurgitation (HP:0001659)1.75685998
160Urethral obstruction (HP:0000796)1.75030047
161Abnormality of oral frenula (HP:0000190)1.74778271
162Blue sclerae (HP:0000592)1.74684440
163Hypoplastic nipples (HP:0002557)1.74468340
164Achilles tendon contracture (HP:0001771)1.72924148
165Elbow flexion contracture (HP:0002987)1.72812134
166Genu recurvatum (HP:0002816)1.72009355
167Alopecia of scalp (HP:0002293)1.71347128
168Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70759900
169Degeneration of the lateral corticospinal tracts (HP:0002314)1.70759900
170Overgrowth (HP:0001548)1.70281395
171Gastrointestinal carcinoma (HP:0002672)1.69751420
172Malignant gastrointestinal tract tumors (HP:0006749)1.69751420
173Abnormality of dentin (HP:0010299)1.69509259
174Bronchomalacia (HP:0002780)1.69139927
175Hyperextensible skin (HP:0000974)1.69093772
176Hand muscle atrophy (HP:0009130)1.68062017
177Congenital glaucoma (HP:0001087)1.67681553
178Striae distensae (HP:0001065)1.66989096
179Germ cell neoplasia (HP:0100728)1.65150328
180Elfin facies (HP:0004428)1.64345551
181Aplasia/Hypoplasia of the scapulae (HP:0006713)1.63356830
182Hypoplastic scapulae (HP:0000882)1.63356830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.68303762
2AKT35.50807651
3LATS13.83442207
4TTN3.78624057
5EEF2K3.47058540
6TAOK33.18615935
7EPHB23.06845740
8EPHA22.92256917
9SIK12.61241878
10DDR22.56078526
11PDGFRA2.35324685
12PTK62.31987349
13MAP3K102.30126131
14NLK2.13310936
15PASK2.03290487
16FRK1.94998842
17TRIB31.92052854
18FER1.91859895
19DMPK1.90786362
20PAK21.83828386
21MET1.82721932
22MYLK1.79477632
23NEK11.77014683
24PKN21.72532701
25ICK1.64806205
26MAP3K21.57980618
27ERN11.55888117
28NTRK31.55424762
29KDR1.54137146
30BMX1.53354852
31RIPK11.51799292
32BCKDK1.49893219
33SCYL21.45342976
34MTOR1.44275246
35FGFR31.39755630
36SGK4941.37645991
37SGK2231.37645991
38SGK21.35976587
39PDK21.30573571
40PINK11.26762515
41STK38L1.22479009
42PTK21.22074726
43TYRO31.20594086
44RPS6KB21.20388384
45PAK41.14857761
46BMPR1B1.11514931
47TGFBR11.10691230
48STK381.09968493
49CAMK1D1.07377281
50NTRK11.03986267
51EPHB11.01127926
52LRRK20.96101346
53TRPM70.96031780
54PRPF4B0.95574776
55NEK90.94594210
56CAMK1G0.92981125
57CSNK1A1L0.92401044
58BRD40.91453483
59CDK30.90225652
60MAPK150.87640535
61STK390.87317789
62STK30.87224925
63PDGFRB0.85886989
64MST1R0.85278516
65NTRK20.85026447
66TNK20.84534603
67EPHA30.82942120
68SGK30.81446191
69LATS20.79647573
70SIK20.78846687
71NUAK10.76458183
72STK110.76334215
73CDK40.76019073
74FGFR20.75918263
75RPS6KA60.73746398
76RET0.73305905
77ROCK10.73205021
78GRK50.72974906
79ZAK0.72502417
80WNK40.71031831
81DYRK1B0.69716468
82PRKD30.65757363
83PAK30.65723263
84MAPK70.63928565
85ROCK20.63709100
86LMTK20.63626825
87TGFBR20.63280585
88NEK20.62001020
89CSF1R0.61460688
90MELK0.61057786
91RPS6KA20.59228860
92PRKAA20.58551042
93FGR0.58497081
94TTK0.55775367
95PIK3CA0.55421876
96CAMK40.55098371
97SGK10.54796726
98PNCK0.54698382
99FGFR10.53943129
100DYRK1A0.53291060
101CDC42BPA0.53140595
102PRKCH0.53059533
103OXSR10.52844026
104MAPKAPK30.52750842
105GSK3A0.51438712
106CDK60.50559462
107NEK60.48365290
108MAPK120.48247426
109WNK30.46950906
110MAP3K130.46234587
111CAMKK10.46110732
112CSNK1G10.45666579
113WNK10.45558962
114INSR0.45184137
115MAP2K40.45014318
116PRKAA10.44971788
117MKNK10.44466479
118MAP4K10.44097342
119TESK20.43750418
120GRK10.43664558
121TLK10.42888983
122TNIK0.41546234
123CSNK1G30.40577913
124PIK3CG0.39328279
125ERBB20.39301369
126CDK120.39201452
127MARK30.37763858
128KSR20.37451708
129AKT20.36964334
130RPS6KC10.35563967
131RPS6KL10.35563967
132CASK0.35051542
133MARK20.34583259
134CSNK1G20.33529774
135PRKACB0.33525227
136CDK80.33393994
137PRKD10.33068507
138MAPK10.32640640
139RPS6KB10.32569007
140PDPK10.32403810
141SRC0.32261416
142PDK10.31419971
143FYN0.30384881
144MAP3K30.30342056
145RPS6KA50.30253888
146FGFR40.30059514
147MAP3K80.29622842
148PRKCG0.28519794
149CSNK1D0.28425316
150CSNK1E0.28202286
151PRKCE0.27261404
152MAP3K70.25820902
153CDK150.23302692
154MAPK80.23132016
155MAP3K40.23082706
156PRKD20.22849189
157JAK10.22317914

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.28945909
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.66814252
3ECM-receptor interaction_Homo sapiens_hsa045122.65643660
4Focal adhesion_Homo sapiens_hsa045102.30785309
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05163500
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.02840001
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01062991
8Adherens junction_Homo sapiens_hsa045201.88895353
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83315274
10Steroid hormone biosynthesis_Homo sapiens_hsa001401.80899772
11Proteoglycans in cancer_Homo sapiens_hsa052051.78367885
12* Hippo signaling pathway_Homo sapiens_hsa043901.78276285
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74061885
14Retinol metabolism_Homo sapiens_hsa008301.73393262
15Chemical carcinogenesis_Homo sapiens_hsa052041.64954563
16Endometrial cancer_Homo sapiens_hsa052131.64347364
17N-Glycan biosynthesis_Homo sapiens_hsa005101.64256030
18Tight junction_Homo sapiens_hsa045301.62881414
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.60451361
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59239468
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58719502
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58706672
23Ovarian steroidogenesis_Homo sapiens_hsa049131.58427284
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.57622435
25mTOR signaling pathway_Homo sapiens_hsa041501.57165807
26Ribosome_Homo sapiens_hsa030101.51873826
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50535055
28Nitrogen metabolism_Homo sapiens_hsa009101.45841738
29Caffeine metabolism_Homo sapiens_hsa002321.44441270
30Fatty acid degradation_Homo sapiens_hsa000711.43648965
31Amoebiasis_Homo sapiens_hsa051461.43643413
32Histidine metabolism_Homo sapiens_hsa003401.42603459
33Bladder cancer_Homo sapiens_hsa052191.42549790
34Prostate cancer_Homo sapiens_hsa052151.41502409
35Gap junction_Homo sapiens_hsa045401.40443982
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39061000
37Basal cell carcinoma_Homo sapiens_hsa052171.38063168
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35777824
39Small cell lung cancer_Homo sapiens_hsa052221.35262693
40Dilated cardiomyopathy_Homo sapiens_hsa054141.32682780
41Protein digestion and absorption_Homo sapiens_hsa049741.31956660
42MicroRNAs in cancer_Homo sapiens_hsa052061.31092401
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.26412587
44Glioma_Homo sapiens_hsa052141.24212941
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.23291714
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22787355
47* TGF-beta signaling pathway_Homo sapiens_hsa043501.20963086
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19785819
49Phenylalanine metabolism_Homo sapiens_hsa003601.18614723
50Sulfur metabolism_Homo sapiens_hsa009201.18496189
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.18168598
52Arginine biosynthesis_Homo sapiens_hsa002201.18142498
53ABC transporters_Homo sapiens_hsa020101.18017747
54Tryptophan metabolism_Homo sapiens_hsa003801.17833531
55ErbB signaling pathway_Homo sapiens_hsa040121.15954753
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15712202
57Tyrosine metabolism_Homo sapiens_hsa003501.11843730
58Chronic myeloid leukemia_Homo sapiens_hsa052201.10660772
59Axon guidance_Homo sapiens_hsa043601.10438740
60Selenocompound metabolism_Homo sapiens_hsa004501.09894504
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07334551
62Lysine degradation_Homo sapiens_hsa003101.06606642
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.05098102
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03650845
65Wnt signaling pathway_Homo sapiens_hsa043101.03427552
66Hedgehog signaling pathway_Homo sapiens_hsa043401.02508641
67PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02373893
68Estrogen signaling pathway_Homo sapiens_hsa049151.00556714
69Butanoate metabolism_Homo sapiens_hsa006501.00075664
70Melanogenesis_Homo sapiens_hsa049160.99999461
71Linoleic acid metabolism_Homo sapiens_hsa005910.99699364
72Renin secretion_Homo sapiens_hsa049240.99436731
73Renal cell carcinoma_Homo sapiens_hsa052110.99364026
74Melanoma_Homo sapiens_hsa052180.98520881
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97661899
76Dorso-ventral axis formation_Homo sapiens_hsa043200.97072680
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94551423
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92813762
79Inositol phosphate metabolism_Homo sapiens_hsa005620.88488108
80Fat digestion and absorption_Homo sapiens_hsa049750.88020689
81Pathways in cancer_Homo sapiens_hsa052000.87983151
82Systemic lupus erythematosus_Homo sapiens_hsa053220.86439334
83Rap1 signaling pathway_Homo sapiens_hsa040150.85789485
84Thyroid hormone synthesis_Homo sapiens_hsa049180.85079168
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85044937
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84603294
87Salivary secretion_Homo sapiens_hsa049700.83716904
88Fatty acid biosynthesis_Homo sapiens_hsa000610.83057753
89PPAR signaling pathway_Homo sapiens_hsa033200.82515332
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82294890
91Vitamin digestion and absorption_Homo sapiens_hsa049770.82248662
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81855904
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.81385621
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80741182
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79906839
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78243481
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78162070
98Oxytocin signaling pathway_Homo sapiens_hsa049210.77850765
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77766337
100Vitamin B6 metabolism_Homo sapiens_hsa007500.77450397
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77170400
102Circadian entrainment_Homo sapiens_hsa047130.77109800
103Colorectal cancer_Homo sapiens_hsa052100.74871403
104Non-small cell lung cancer_Homo sapiens_hsa052230.74428591
105Glycerolipid metabolism_Homo sapiens_hsa005610.74272017
106Peroxisome_Homo sapiens_hsa041460.74250887
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74145283
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73962530
109Alcoholism_Homo sapiens_hsa050340.72880661
110Sulfur relay system_Homo sapiens_hsa041220.72830781
111AMPK signaling pathway_Homo sapiens_hsa041520.72729808
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71899103
113GnRH signaling pathway_Homo sapiens_hsa049120.71838613
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71314800
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.70154013
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69223035
117Viral carcinogenesis_Homo sapiens_hsa052030.68854490
118Pancreatic cancer_Homo sapiens_hsa052120.68734662
119Bile secretion_Homo sapiens_hsa049760.67992727
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67357985
121FoxO signaling pathway_Homo sapiens_hsa040680.65245059
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64794578
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64579205
124Platelet activation_Homo sapiens_hsa046110.63764723
125Arachidonic acid metabolism_Homo sapiens_hsa005900.63046400
126Choline metabolism in cancer_Homo sapiens_hsa052310.62991017
127Type II diabetes mellitus_Homo sapiens_hsa049300.61976504
128Lysosome_Homo sapiens_hsa041420.61025017
129Starch and sucrose metabolism_Homo sapiens_hsa005000.60434640
130Insulin secretion_Homo sapiens_hsa049110.60308580
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59241781
132Ras signaling pathway_Homo sapiens_hsa040140.58344799
133Oocyte meiosis_Homo sapiens_hsa041140.58057932
134Propanoate metabolism_Homo sapiens_hsa006400.56825103
135Gastric acid secretion_Homo sapiens_hsa049710.56770509
136Staphylococcus aureus infection_Homo sapiens_hsa051500.54671846
137Cocaine addiction_Homo sapiens_hsa050300.54431319
138Notch signaling pathway_Homo sapiens_hsa043300.52895714
139Insulin resistance_Homo sapiens_hsa049310.52714311
140Fructose and mannose metabolism_Homo sapiens_hsa000510.52459219
141Endocytosis_Homo sapiens_hsa041440.52122739
142Arginine and proline metabolism_Homo sapiens_hsa003300.51944639
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48951645
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45315961
145Serotonergic synapse_Homo sapiens_hsa047260.43722659
146Circadian rhythm_Homo sapiens_hsa047100.43608450
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.42455495
148Fatty acid metabolism_Homo sapiens_hsa012120.41820267
149HTLV-I infection_Homo sapiens_hsa051660.38792334
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38521433
151Drug metabolism - other enzymes_Homo sapiens_hsa009830.30478027
152MAPK signaling pathway_Homo sapiens_hsa040100.27369434
153Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26703269
154HIF-1 signaling pathway_Homo sapiens_hsa040660.25352253
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23902676

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