GDF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)8.71053900
2negative regulation of meiotic cell cycle (GO:0051447)8.58042704
3protein kinase C signaling (GO:0070528)8.07800257
4regulation of meiosis (GO:0040020)8.06937529
5meiotic cell cycle (GO:0051321)7.42713920
6mitotic chromosome condensation (GO:0007076)7.37882274
7attachment of spindle microtubules to kinetochore (GO:0008608)7.28474309
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)7.13902522
9piRNA metabolic process (GO:0034587)7.06420218
10regulation of meiosis I (GO:0060631)7.01608048
11regulation of acrosome reaction (GO:0060046)6.60949910
12retinal cone cell development (GO:0046549)6.51536866
13* regulation of female gonad development (GO:2000194)6.43444702
14protein localization to kinetochore (GO:0034501)6.42281470
15positive regulation of histone H3-K4 methylation (GO:0051571)6.41900956
16regulation of meiotic cell cycle (GO:0051445)6.40156511
17regulation of histone H3-K9 methylation (GO:0051570)6.31785633
18negative regulation of meiosis (GO:0045835)6.26645128
19establishment of spindle localization (GO:0051293)6.25023583
20mitotic metaphase plate congression (GO:0007080)6.05877059
21* female gamete generation (GO:0007292)5.96755567
22establishment of spindle orientation (GO:0051294)5.75376706
23binding of sperm to zona pellucida (GO:0007339)5.58871687
24protein localization to chromosome, centromeric region (GO:0071459)5.55015467
25negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)5.45530542
26protein K6-linked ubiquitination (GO:0085020)5.38659793
27multicellular organism reproduction (GO:0032504)5.23268359
28glycine transport (GO:0015816)5.17059622
29metaphase plate congression (GO:0051310)5.12673579
30base-excision repair, AP site formation (GO:0006285)5.07324898
31regulation of histone H3-K27 methylation (GO:0061085)4.94198839
32regulation of cell maturation (GO:1903429)4.88541371
33regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.85464491
34regulation of hypersensitivity (GO:0002883)4.85015158
35histone H2A monoubiquitination (GO:0035518)4.83393277
36negative regulation of reproductive process (GO:2000242)4.71490745
37single fertilization (GO:0007338)4.66878854
38establishment of chromosome localization (GO:0051303)4.65635533
39DNA methylation involved in gamete generation (GO:0043046)4.60854657
40positive regulation of reproductive process (GO:2000243)4.59907151
41positive regulation of gastrulation (GO:2000543)4.58337697
42protein localization to chromosome (GO:0034502)4.56311966
43oocyte maturation (GO:0001556)4.51205825
44regulation of calcium ion-dependent exocytosis (GO:0017158)4.48987823
45histone H2A ubiquitination (GO:0033522)4.43478933
46sperm-egg recognition (GO:0035036)4.40522041
47negative regulation of histone methylation (GO:0031061)4.39159611
48centriole replication (GO:0007099)4.36961037
49synapsis (GO:0007129)4.30600101
50regulation of mitotic spindle organization (GO:0060236)4.30365980
51negative regulation of DNA-templated transcription, elongation (GO:0032785)4.30291718
52negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.30291718
53CENP-A containing nucleosome assembly (GO:0034080)4.30029844
54mitotic sister chromatid segregation (GO:0000070)4.25455747
55negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.22972759
56pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.20807249
57regulation of exit from mitosis (GO:0007096)4.17293590
58primitive streak formation (GO:0090009)4.15958775
59chromatin remodeling at centromere (GO:0031055)4.09865274
60male meiosis I (GO:0007141)4.09360916
61regulation of sister chromatid cohesion (GO:0007063)4.02776026
62positive regulation of chromosome segregation (GO:0051984)4.02555889
63reproduction (GO:0000003)3.99731196
64synaptonemal complex assembly (GO:0007130)3.96243969
65positive regulation of histone methylation (GO:0031062)3.94190110
66DNA damage induced protein phosphorylation (GO:0006975)3.92824826
67glycerophospholipid catabolic process (GO:0046475)3.92121732
68chromatin assembly or disassembly (GO:0006333)3.90974268
69regulation of spindle organization (GO:0090224)3.87329264
70histone exchange (GO:0043486)3.83237167
71positive regulation of humoral immune response (GO:0002922)3.83202154
72regulation of phospholipid biosynthetic process (GO:0071071)3.82893930
73regulation of histone H3-K4 methylation (GO:0051569)3.81412650
74regulation of steroid hormone biosynthetic process (GO:0090030)3.79706162
75chromosome organization involved in meiosis (GO:0070192)3.73916723
76regulation of autophagic vacuole assembly (GO:2000785)3.73015207
77notochord development (GO:0030903)3.71044380
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.70726038
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.70726038
80positive regulation of mitotic sister chromatid separation (GO:1901970)3.70726038
81positive regulation of uterine smooth muscle contraction (GO:0070474)3.70615239
82male meiosis (GO:0007140)3.66566209
83DNA replication-independent nucleosome organization (GO:0034724)3.66157372
84DNA replication-independent nucleosome assembly (GO:0006336)3.66157372
85negative regulation of smooth muscle cell differentiation (GO:0051151)3.65157231
86positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.59919483
87synaptonemal complex organization (GO:0070193)3.59424599
88folic acid-containing compound biosynthetic process (GO:0009396)3.58911006
89citrulline biosynthetic process (GO:0019240)3.57746042
90oocyte development (GO:0048599)3.55324383
91cell-cell recognition (GO:0009988)3.54742828
92gene silencing by RNA (GO:0031047)3.50115346
93meiosis I (GO:0007127)3.49824574
94chromatin assembly (GO:0031497)3.48236229
95spindle checkpoint (GO:0031577)3.47924124
96phosphorelay signal transduction system (GO:0000160)3.46275150
97cytoskeleton-dependent cytokinesis (GO:0061640)3.45710880
98sister chromatid segregation (GO:0000819)3.45008567
99pyrimidine nucleotide catabolic process (GO:0006244)3.44638811
100DNA alkylation (GO:0006305)3.43962298
101DNA methylation (GO:0006306)3.43962298
102phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.43093898
103fertilization (GO:0009566)3.42773944
104* regulation of reproductive process (GO:2000241)3.42465455
105regulation of transforming growth factor beta2 production (GO:0032909)3.39614282
106chromosome segregation (GO:0007059)3.38815177
107one-carbon metabolic process (GO:0006730)3.38791335
108negative regulation of cAMP-mediated signaling (GO:0043951)3.38764751
109regulation of histone methylation (GO:0031060)3.37979917
110mitotic nuclear envelope disassembly (GO:0007077)3.37899740
111regulation of chromatin silencing (GO:0031935)3.34555199
112L-amino acid import (GO:0043092)3.34520394
113oogenesis (GO:0048477)3.34344638
114regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33385377
115regulation of retinoic acid receptor signaling pathway (GO:0048385)3.32434456
116gene silencing (GO:0016458)3.31616427
117maturation of 5.8S rRNA (GO:0000460)3.31569807
118membrane tubulation (GO:0097320)3.30700102
119meiotic nuclear division (GO:0007126)3.29912076
120regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.29096967
121microtubule severing (GO:0051013)3.28162171
122negative regulation of hormone biosynthetic process (GO:0032353)3.24206543
123interkinetic nuclear migration (GO:0022027)3.24015439
124N-terminal protein amino acid acetylation (GO:0006474)3.23807175
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21715213
126nuclear envelope disassembly (GO:0051081)3.21604406
127membrane disassembly (GO:0030397)3.21604406
128negative regulation of histone modification (GO:0031057)3.18199002
129negative regulation of nuclear division (GO:0051784)3.14391841
130cytoplasmic mRNA processing body assembly (GO:0033962)3.14268226
131chaperone-mediated protein transport (GO:0072321)3.14209788
132regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.14140131
133positive regulation of Cdc42 GTPase activity (GO:0043089)3.13520726
134meiotic chromosome segregation (GO:0045132)3.13354010
135DNA replication-dependent nucleosome organization (GO:0034723)3.13283818
136DNA replication-dependent nucleosome assembly (GO:0006335)3.13283818
137microtubule nucleation (GO:0007020)3.13159423
138muscle cell migration (GO:0014812)3.12741382
139histone H3-K9 demethylation (GO:0033169)3.12393283
140microtubule anchoring (GO:0034453)3.11912221
141mitotic spindle checkpoint (GO:0071174)3.11731916
142negative regulation of hormone metabolic process (GO:0032351)3.11251759
143DNA replication checkpoint (GO:0000076)3.10221416
144somite rostral/caudal axis specification (GO:0032525)3.08967313
145endothelium development (GO:0003158)3.08858836
146regulation of chromosome segregation (GO:0051983)3.06879052
147phosphatidylinositol dephosphorylation (GO:0046856)3.06422324
148citrulline metabolic process (GO:0000052)3.06313341
149negative regulation of chromosome segregation (GO:0051985)3.05484027
150regulation of corticosteroid hormone secretion (GO:2000846)3.05392362
151meiotic cell cycle process (GO:1903046)3.05048151
152neuron fate determination (GO:0048664)3.03962660
153positive regulation of meiosis (GO:0045836)3.03578810
154negative regulation of execution phase of apoptosis (GO:1900118)2.99781604
155relaxation of smooth muscle (GO:0044557)2.96544080
156nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.96491960
157type B pancreatic cell development (GO:0003323)2.96329739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.16433041
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.05941114
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.30103752
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.29252945
5AR_21909140_ChIP-Seq_LNCAP_Human3.99676877
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.97158869
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.70181948
8EZH2_22144423_ChIP-Seq_EOC_Human3.63157465
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.31639545
10E2F7_22180533_ChIP-Seq_HELA_Human3.29763711
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.78630743
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.78630743
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.78630743
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.67128691
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.52029712
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42091133
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.40258112
18KAP1_22055183_ChIP-Seq_ESCs_Mouse2.36956674
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33636447
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29850744
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.24313566
22RUNX1_26923725_Chip-Seq_HPCs_Mouse2.15826567
23MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.98545837
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90933626
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.89972953
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85284270
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.80318944
28GBX2_23144817_ChIP-Seq_PC3_Human1.71023166
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67494913
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.67360555
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63043381
32FOXM1_26456572_ChIP-Seq_MCF-7_Human1.58040258
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57935371
34* MYC_18940864_ChIP-ChIP_HL60_Human1.57861027
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57623303
36TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.53765170
37EWS_26573619_Chip-Seq_HEK293_Human1.49385556
38CDX2_22108803_ChIP-Seq_LS180_Human1.45233902
39CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43301746
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37778494
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37048701
42SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36868418
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.36427005
44RNF2_27304074_Chip-Seq_NSC_Mouse1.32917389
45CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32192384
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.29588359
47FUS_26573619_Chip-Seq_HEK293_Human1.28768474
48VDR_22108803_ChIP-Seq_LS180_Human1.27887528
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26989682
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25966396
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.25717480
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23627342
53NANOG_21062744_ChIP-ChIP_HESCs_Human1.20161274
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19726740
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19504766
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19457633
57STAT3_23295773_ChIP-Seq_U87_Human1.18439408
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.17531853
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17511434
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17245291
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17100678
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14817742
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14787274
64ERG_20517297_ChIP-Seq_VCAP_Human1.14469796
65GF1B_26923725_Chip-Seq_HPCs_Mouse1.14178528
66CBP_20019798_ChIP-Seq_JUKART_Human1.13642865
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13642865
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13624949
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13221743
70BCAT_22108803_ChIP-Seq_LS180_Human1.12775001
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12507149
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12281846
73SMRT_27268052_Chip-Seq_Bcells_Human1.11028094
74TCF4_23295773_ChIP-Seq_U87_Human1.10490030
75TP63_23658742_ChIP-Seq_EP156T_Human1.09221614
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09013872
77ZNF274_21170338_ChIP-Seq_K562_Hela1.08061785
78MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07511660
79CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07066492
80IRF1_19129219_ChIP-ChIP_H3396_Human1.07003640
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06564405
82GATA3_21867929_ChIP-Seq_TH1_Mouse1.06290757
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06053632
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06047372
85NFYA_21822215_ChIP-Seq_K562_Human1.05425127
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.05125437
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04724336
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04636573
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04503703
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02942885
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01044664
92NANOG_20526341_ChIP-Seq_ESCs_Human1.00568678
93CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99889169
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.97709136
95SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96920907
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95940093
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95940093
98SMAD4_21799915_ChIP-Seq_A2780_Human0.95608716
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92923044
100RUNX2_22187159_ChIP-Seq_PCA_Human0.91985903
101IGF1R_20145208_ChIP-Seq_DFB_Human0.91075226
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90164005
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89543658
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89537797
105FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89467198
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89360131
107* OCT1_27270436_Chip-Seq_PROSTATE_Human0.89028101
108SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88218399
109NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87877276
110ESR1_21235772_ChIP-Seq_MCF-7_Human0.87780669
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87666875
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87567499
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87036107
114P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86345166
115GATA3_26560356_Chip-Seq_TH1_Human0.85624156
116AR_25329375_ChIP-Seq_VCAP_Human0.85561063
117GF1_26923725_Chip-Seq_HPCs_Mouse0.85300526
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84506563
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84075545
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83920300
121CBP_21632823_ChIP-Seq_H3396_Human0.83791709
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83774717
123ESET_19884257_ChIP-Seq_ESCs_Mouse0.83605017
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83489276
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.82938090
126TP53_22573176_ChIP-Seq_HFKS_Human0.82017519
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.81777778
128AR_21572438_ChIP-Seq_LNCaP_Human0.81288328
129FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80836844
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79841032
131FOXP3_21729870_ChIP-Seq_TREG_Human0.79486315
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.78314645
133BP1_19119308_ChIP-ChIP_Hs578T_Human0.78110531
134CJUN_26792858_Chip-Seq_BT549_Human0.78016446
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76900300
136EST1_17652178_ChIP-ChIP_JURKAT_Human0.76864377
137SALL4_22934838_ChIP-ChIP_CD34+_Human0.76755916
138GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75500417
139HTT_18923047_ChIP-ChIP_STHdh_Human0.74266716
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.74252089
141P300_19829295_ChIP-Seq_ESCs_Human0.70961949
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.68717489
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.68585238
144PKCTHETA_26484144_Chip-Seq_BREAST_Human0.66926792
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.65123184
146PADI4_21655091_ChIP-ChIP_MCF-7_Human0.63582102
147* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.63362206
148* KLF4_19829295_ChIP-Seq_ESCs_Human0.63120436
149AHR_22903824_ChIP-Seq_MCF-7_Human0.61587478
150YY1_21170310_ChIP-Seq_MESCs_Mouse0.61111450
151GATA3_21878914_ChIP-Seq_MCF-7_Human0.60540150
152NANOG_18555785_ChIP-Seq_MESCs_Mouse0.60522781
153ESR1_15608294_ChIP-ChIP_MCF-7_Human0.60033358
154AR_20517297_ChIP-Seq_VCAP_Human0.59626725
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.59610987
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.59610987
157REST_21632747_ChIP-Seq_MESCs_Mouse0.59169982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.61740909
2MP0005451_abnormal_body_composition6.56486057
3MP0002653_abnormal_ependyma_morphology4.20627846
4MP0008789_abnormal_olfactory_epithelium4.06574057
5MP0003646_muscle_fatigue3.87783808
6MP0005395_other_phenotype3.87362470
7MP0005499_abnormal_olfactory_system3.62860330
8MP0005394_taste/olfaction_phenotype3.62860330
9MP0010094_abnormal_chromosome_stability3.40109393
10MP0002139_abnormal_hepatobiliary_system3.35882745
11* MP0003699_abnormal_female_reproductive3.24005226
12* MP0001119_abnormal_female_reproductive3.11525024
13MP0002138_abnormal_hepatobiliary_system3.00629033
14MP0003693_abnormal_embryo_hatching2.95527142
15MP0008877_abnormal_DNA_methylation2.85907334
16MP0003111_abnormal_nucleus_morphology2.76808073
17MP0008057_abnormal_DNA_replication2.57412233
18MP0010030_abnormal_orbit_morphology2.51803087
19MP0002102_abnormal_ear_morphology2.50260730
20MP0003077_abnormal_cell_cycle2.44773214
21MP0004264_abnormal_extraembryonic_tissu2.39622165
22MP0002234_abnormal_pharynx_morphology2.27378233
23* MP0001929_abnormal_gametogenesis2.23993984
24MP0006072_abnormal_retinal_apoptosis2.16604812
25MP0001915_intracranial_hemorrhage2.15877740
26* MP0000653_abnormal_sex_gland2.12119063
27MP0004859_abnormal_synaptic_plasticity2.09655767
28MP0004957_abnormal_blastocyst_morpholog2.06037466
29MP0003879_abnormal_hair_cell2.03466107
30MP0002295_abnormal_pulmonary_circulatio2.02273912
31MP0003705_abnormal_hypodermis_morpholog1.97365349
32MP0008058_abnormal_DNA_repair1.95561057
33MP0005410_abnormal_fertilization1.92122839
34MP0001905_abnormal_dopamine_level1.75300356
35* MP0002161_abnormal_fertility/fecundity1.69827628
36MP0008260_abnormal_autophagy1.62185082
37MP0003183_abnormal_peptide_metabolism1.59940222
38MP0000566_synostosis1.57073846
39MP0010234_abnormal_vibrissa_follicle1.54200174
40MP0008932_abnormal_embryonic_tissue1.53430723
41* MP0002210_abnormal_sex_determination1.51908981
42MP0000579_abnormal_nail_morphology1.50450555
43MP0005408_hypopigmentation1.50044919
44MP0002160_abnormal_reproductive_system1.47662514
45MP0003121_genomic_imprinting1.46939925
46MP0010307_abnormal_tumor_latency1.44611116
47MP0009840_abnormal_foam_cell1.44486462
48MP0003950_abnormal_plasma_membrane1.42437305
49MP0002932_abnormal_joint_morphology1.38795367
50MP0001293_anophthalmia1.33497196
51MP0001984_abnormal_olfaction1.27340766
52MP0003937_abnormal_limbs/digits/tail_de1.25769101
53MP0006292_abnormal_olfactory_placode1.24354911
54MP0001919_abnormal_reproductive_system1.24322853
55MP0003252_abnormal_bile_duct1.23595013
56MP0001485_abnormal_pinna_reflex1.23303812
57MP0000350_abnormal_cell_proliferation1.21481353
58MP0001529_abnormal_vocalization1.17094416
59MP0001986_abnormal_taste_sensitivity1.14272327
60MP0000762_abnormal_tongue_morphology1.11054682
61MP0008875_abnormal_xenobiotic_pharmacok1.10742642
62MP0005310_abnormal_salivary_gland1.10261902
63MP0003453_abnormal_keratinocyte_physiol1.09471655
64MP0002019_abnormal_tumor_incidence1.08457207
65MP0001849_ear_inflammation1.06985600
66MP0002233_abnormal_nose_morphology1.05967146
67MP0000427_abnormal_hair_cycle1.03107998
68MP0001730_embryonic_growth_arrest1.01775714
69MP0004185_abnormal_adipocyte_glucose1.01683865
70MP0003787_abnormal_imprinting1.01128753
71MP0008007_abnormal_cellular_replicative1.00852813
72MP0004142_abnormal_muscle_tone0.99645341
73MP0009379_abnormal_foot_pigmentation0.99313937
74MP0001145_abnormal_male_reproductive0.97591547
75MP0005197_abnormal_uvea_morphology0.97491509
76MP0002085_abnormal_embryonic_tissue0.97351654
77MP0009697_abnormal_copulation0.93955679
78MP0005647_abnormal_sex_gland0.93756635
79MP0002272_abnormal_nervous_system0.93314589
80MP0003119_abnormal_digestive_system0.93061599
81MP0004510_myositis0.93045893
82MP0003763_abnormal_thymus_physiology0.92587304
83MP0005023_abnormal_wound_healing0.91342951
84MP0006276_abnormal_autonomic_nervous0.91042691
85MP0001666_abnormal_nutrient_absorption0.90923833
86MP0003315_abnormal_perineum_morphology0.90065191
87MP0005551_abnormal_eye_electrophysiolog0.88427201
88MP0001697_abnormal_embryo_size0.87978118
89MP0005085_abnormal_gallbladder_physiolo0.87462132
90MP0010368_abnormal_lymphatic_system0.86538594
91MP0002084_abnormal_developmental_patter0.85453130
92MP0002933_joint_inflammation0.83605240
93MP0000639_abnormal_adrenal_gland0.82524813
94MP0001664_abnormal_digestion0.82453347
95MP0005075_abnormal_melanosome_morpholog0.82370874
96MP0005389_reproductive_system_phenotype0.82056477
97MP0001672_abnormal_embryogenesis/_devel0.81495632
98MP0005380_embryogenesis_phenotype0.81495632
99MP0002249_abnormal_larynx_morphology0.77645113
100MP0005621_abnormal_cell_physiology0.76824447
101MP0009384_cardiac_valve_regurgitation0.75675083
102MP0002177_abnormal_outer_ear0.74160249
103MP0003136_yellow_coat_color0.71347954
104MP0001324_abnormal_eye_pigmentation0.70595163
105MP0010386_abnormal_urinary_bladder0.69208640
106MP0003868_abnormal_feces_composition0.66726898
107MP0005360_urolithiasis0.65522018
108MP0003890_abnormal_embryonic-extraembry0.65279870
109MP0003195_calcinosis0.64665628
110MP0000490_abnormal_crypts_of0.63777868
111MP0010678_abnormal_skin_adnexa0.63218012
112MP0010352_gastrointestinal_tract_polyps0.61972721
113MP0005187_abnormal_penis_morphology0.60378359
114MP0000465_gastrointestinal_hemorrhage0.57735988
115MP0008995_early_reproductive_senescence0.56770006
116MP0000049_abnormal_middle_ear0.55928290
117MP0000383_abnormal_hair_follicle0.55853552
118MP0002168_other_aberrant_phenotype0.55812594
119MP0003075_altered_response_to0.53848077
120MP0003755_abnormal_palate_morphology0.53559318
121MP0003959_abnormal_lean_body0.51679377
122MP0001346_abnormal_lacrimal_gland0.51537537
123MP0001502_abnormal_circadian_rhythm0.51231511
124MP0001963_abnormal_hearing_physiology0.50297476
125MP0000631_abnormal_neuroendocrine_gland0.49881003
126MP0005384_cellular_phenotype0.49478320
127MP0002928_abnormal_bile_duct0.49094510
128MP0002127_abnormal_cardiovascular_syste0.49054906
129MP0005257_abnormal_intraocular_pressure0.48359688
130MP0002796_impaired_skin_barrier0.48273931
131MP0002877_abnormal_melanocyte_morpholog0.47690000
132MP0003698_abnormal_male_reproductive0.47227565
133MP0003861_abnormal_nervous_system0.46497030
134MP0000477_abnormal_intestine_morphology0.46394500
135MP0003123_paternal_imprinting0.44983254
136MP0000015_abnormal_ear_pigmentation0.42987781
137MP0000678_abnormal_parathyroid_gland0.42861207
138MP0002098_abnormal_vibrissa_morphology0.42666062
139MP0002089_abnormal_postnatal_growth/wei0.41781095
140MP0001881_abnormal_mammary_gland0.41775383
141MP0003941_abnormal_skin_development0.41734466
142MP0005501_abnormal_skin_physiology0.41569877
143MP0003786_premature_aging0.41467558
144MP0002638_abnormal_pupillary_reflex0.40985396
145MP0000377_abnormal_hair_follicle0.40764181
146MP0000462_abnormal_digestive_system0.40477353
147MP0005166_decreased_susceptibility_to0.40055071
148MP0000733_abnormal_muscle_development0.40015279
149MP0002095_abnormal_skin_pigmentation0.39555095
150MP0000313_abnormal_cell_death0.39423831
151MP0002080_prenatal_lethality0.38941910
152MP0003984_embryonic_growth_retardation0.38888783
153MP0005646_abnormal_pituitary_gland0.38479203
154MP0000372_irregular_coat_pigmentation0.38347203
155MP0004484_altered_response_of0.37885156
156MP0002736_abnormal_nociception_after0.37661832
157MP0002090_abnormal_vision0.36964514
158MP0002751_abnormal_autonomic_nervous0.36223080
159MP0003935_abnormal_craniofacial_develop0.36161850
160MP0002088_abnormal_embryonic_growth/wei0.35984903

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.88268175
2Abnormal gallbladder physiology (HP:0012438)6.00369348
3Cholecystitis (HP:0001082)6.00369348
4Aplasia/Hypoplasia of the fovea (HP:0008060)5.53668386
5Hypoplasia of the fovea (HP:0007750)5.53668386
6Anterior segment dysgenesis (HP:0007700)5.29866215
7Abdominal situs inversus (HP:0003363)4.96782122
8Abnormality of abdominal situs (HP:0011620)4.96782122
9Birth length less than 3rd percentile (HP:0003561)4.96536083
10Infertility (HP:0000789)4.75655421
11Abnormality of the fovea (HP:0000493)4.67422494
12Rhabdomyosarcoma (HP:0002859)4.42830813
13Osteomalacia (HP:0002749)4.40984764
14Premature ovarian failure (HP:0008209)4.38666569
15Cortical dysplasia (HP:0002539)4.35104838
16Lip pit (HP:0100267)4.30880863
17Breast hypoplasia (HP:0003187)4.25243240
18Hypophosphatemic rickets (HP:0004912)4.16243070
19Chromsome breakage (HP:0040012)3.97665682
20Septo-optic dysplasia (HP:0100842)3.96946095
21Papillary thyroid carcinoma (HP:0002895)3.86836024
22Aplasia/Hypoplasia of the sternum (HP:0006714)3.82388935
23Secondary amenorrhea (HP:0000869)3.72625071
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.72607882
25Azoospermia (HP:0000027)3.72254982
26Abnormality of the labia minora (HP:0012880)3.68684095
27Hypergonadotropic hypogonadism (HP:0000815)3.54331045
28Aplasia/Hypoplasia of the macula (HP:0008059)3.47415205
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.42031138
30Short 1st metacarpal (HP:0010034)3.36936347
31Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.36936347
32Absent septum pellucidum (HP:0001331)3.35666005
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.31074512
34Median cleft lip (HP:0000161)3.28324366
35Neoplasm of striated muscle (HP:0009728)3.26141404
36Combined immunodeficiency (HP:0005387)3.22057691
37Aplasia/Hypoplasia affecting the retina (HP:0008061)3.18850122
38Short tibia (HP:0005736)3.15022771
39Gonadotropin excess (HP:0000837)3.08562703
40Hypokinesia (HP:0002375)3.01319049
41Chronic bronchitis (HP:0004469)2.97939987
42Abnormality of chromosome segregation (HP:0002916)2.91174785
43Abnormality of the 1st metacarpal (HP:0010009)2.89805987
44Abnormality of the septum pellucidum (HP:0007375)2.89420638
45Overlapping toe (HP:0001845)2.84191545
46Arterial tortuosity (HP:0005116)2.83733751
47Abnormal spermatogenesis (HP:0008669)2.82111056
48Patellar aplasia (HP:0006443)2.80517290
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.79165235
50Abnormality of the proximal phalanges of the hand (HP:0009834)2.77721106
51Oligodactyly (HP:0012165)2.74807374
52Adrenal hypoplasia (HP:0000835)2.74759847
53Pulmonary fibrosis (HP:0002206)2.72202153
54Shawl scrotum (HP:0000049)2.61906296
55Myokymia (HP:0002411)2.61652219
56Abnormality of lateral ventricle (HP:0030047)2.61510359
57Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.58390002
58Sandal gap (HP:0001852)2.55096403
59Enlarged penis (HP:0000040)2.53174244
60Aplasia/Hypoplasia of the patella (HP:0006498)2.51515450
61Short phalanx of the thumb (HP:0009660)2.48978149
62Urethral obstruction (HP:0000796)2.47245502
63Wrist flexion contracture (HP:0001239)2.46743929
64Intrahepatic cholestasis (HP:0001406)2.46057773
65Anhidrosis (HP:0000970)2.45594978
66Aplasia of the musculature (HP:0100854)2.45284618
67Vascular tortuosity (HP:0004948)2.44706300
68Fibular aplasia (HP:0002990)2.44390938
69Fair hair (HP:0002286)2.42723018
70Truncal obesity (HP:0001956)2.42218699
71Duodenal stenosis (HP:0100867)2.38059764
72Small intestinal stenosis (HP:0012848)2.38059764
73Flat capital femoral epiphysis (HP:0003370)2.36836908
74Lower limb hyperreflexia (HP:0002395)2.35421059
75Metaphyseal irregularity (HP:0003025)2.34821426
76Nephroblastoma (Wilms tumor) (HP:0002667)2.32466740
77Insulin-resistant diabetes mellitus (HP:0000831)2.29599104
78Aplasia involving bones of the extremities (HP:0009825)2.29428054
79Aplasia involving bones of the upper limbs (HP:0009823)2.29428054
80Aplasia of the phalanges of the hand (HP:0009802)2.29428054
81Spinal cord compression (HP:0002176)2.29147348
82Fetal akinesia sequence (HP:0001989)2.28629123
83Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.27449561
84Aplasia/Hypoplasia of the tongue (HP:0010295)2.25939734
85Sensory axonal neuropathy (HP:0003390)2.25847570
86Abnormal ciliary motility (HP:0012262)2.25186133
87Facial hemangioma (HP:0000329)2.25096061
88Apathy (HP:0000741)2.23074787
89Congenital sensorineural hearing impairment (HP:0008527)2.22248201
90Aplasia/Hypoplasia involving the musculature (HP:0001460)2.22102328
91Bile duct proliferation (HP:0001408)2.21176120
92Abnormal biliary tract physiology (HP:0012439)2.21176120
93Loss of speech (HP:0002371)2.20040444
94Impulsivity (HP:0100710)2.20025539
95Dysdiadochokinesis (HP:0002075)2.18650193
96Malnutrition (HP:0004395)2.18638185
97Maternal diabetes (HP:0009800)2.18012514
98Leiomyosarcoma (HP:0100243)2.17694341
99Uterine leiomyosarcoma (HP:0002891)2.17694341
100Abnormality of cochlea (HP:0000375)2.17071678
101Stillbirth (HP:0003826)2.16347468
102Muscle stiffness (HP:0003552)2.15496505
103Abnormality of the anterior chamber (HP:0000593)2.15084010
104Embryonal renal neoplasm (HP:0011794)2.14917721
105Capillary hemangiomas (HP:0005306)2.14359610
106Skin pits (HP:0100276)2.14264525
107Abnormality of chromosome stability (HP:0003220)2.13949904
108Atelectasis (HP:0100750)2.13808284
109Diastasis recti (HP:0001540)2.13219244
110Sex reversal (HP:0012245)2.11320067
111Abnormal sex determination (HP:0012244)2.11320067
112Bundle branch block (HP:0011710)2.10170614
113Abnormal lung lobation (HP:0002101)2.08080623
114Proximal tubulopathy (HP:0000114)2.07041263
115Generalized aminoaciduria (HP:0002909)2.04266226
116Hypoplastic iliac wings (HP:0002866)2.04264857
117Aplasia/Hypoplasia of the breasts (HP:0010311)2.04080924
118Amniotic constriction ring (HP:0009775)2.02984929
119Abnormality of placental membranes (HP:0011409)2.02984929
120Conjunctival telangiectasia (HP:0000524)2.02950658
121Breast aplasia (HP:0100783)2.02725382
122Diminished motivation (HP:0000745)2.01253673
123Male infertility (HP:0003251)10.1685217
124Short thumb (HP:0009778)1.99901237
125Rhinitis (HP:0012384)1.99562227
126Cone-rod dystrophy (HP:0000548)1.99294894
127Primary amenorrhea (HP:0000786)1.98674658
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.98472972
129Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.97861079
130Posterior subcapsular cataract (HP:0007787)1.97828841
131Oligodactyly (hands) (HP:0001180)1.97304896
132Limb hypertonia (HP:0002509)1.97207197
133Abnormality of the fingertips (HP:0001211)1.96391334
134Striae distensae (HP:0001065)1.95444476
135Increased circulating renin level (HP:0000848)1.95174180
136Spondylolisthesis (HP:0003302)1.94933127
137Transitional cell carcinoma of the bladder (HP:0006740)1.92614514
138Abnormality of the phalanges of the hallux (HP:0010057)1.92027829
139Aplasia involving forearm bones (HP:0009822)1.91778814
140Absent forearm bone (HP:0003953)1.91778814
141Chin dimple (HP:0010751)1.90331955
142Stenosis of the external auditory canal (HP:0000402)1.89508764
143Absent radius (HP:0003974)1.89285429
144Rib fusion (HP:0000902)1.89282326
145Abnormality of the preputium (HP:0100587)1.88926858
146Abnormal respiratory motile cilium physiology (HP:0012261)1.88800035
147Acute myeloid leukemia (HP:0004808)1.88089128
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87984635
149Abnormality of alanine metabolism (HP:0010916)1.87984635
150Hyperalaninemia (HP:0003348)1.87984635
151Termporal pattern (HP:0011008)1.86789639
152Insidious onset (HP:0003587)1.86789639
153Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85971515
154Meckel diverticulum (HP:0002245)1.85743897
155Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84318033
156Abnormality of the duodenum (HP:0002246)1.83859587
157Cleft eyelid (HP:0000625)1.83400280
158Gaze-evoked nystagmus (HP:0000640)1.83062659
159Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83015802
160Molar tooth sign on MRI (HP:0002419)1.81742158
161Abnormality of midbrain morphology (HP:0002418)1.81742158
162Thyroid carcinoma (HP:0002890)1.81559342
163Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81233973
164Supernumerary spleens (HP:0009799)1.80049767
165Sloping forehead (HP:0000340)1.79897549
166Methylmalonic acidemia (HP:0002912)1.78655871
167Abnormality of the ileum (HP:0001549)1.78516088
168Abnormality of the intervertebral disk (HP:0005108)1.77966208
169Ankle contracture (HP:0006466)1.77733568
170Medulloblastoma (HP:0002885)1.77266912
171Hip contracture (HP:0003273)1.76204608
172Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75214829
173Cholelithiasis (HP:0001081)1.75149241
174Bladder carcinoma (HP:0002862)1.73941442
175Bladder neoplasm (HP:0009725)1.73941442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR28.66388885
2MOS7.90888092
3TAOK36.25088432
4CDK123.47131514
5NEK63.26160730
6STK242.88491767
7TTK2.79155933
8MAP3K62.59356461
9MET2.39627870
10MAP3K92.36649428
11PLK42.34925212
12LATS12.32786922
13STK102.19012859
14LATS22.12769707
15MAP3K132.02238966
16KSR22.00133506
17CDC71.92597179
18ARAF1.76837798
19PRKCI1.76572426
20EIF2AK31.64581229
21TRIM281.61618533
22TAOK11.52818422
23TNIK1.48470337
24STK38L1.45895906
25CDK81.45037035
26CDK91.42630621
27BRAF1.42289190
28DYRK21.38641268
29ZAK1.37933969
30MELK1.31985112
31MST41.20707168
32NLK1.18566402
33NUAK11.16106911
34BRSK11.13788175
35CSNK1G11.13757505
36RAF11.11132347
37PRKD31.08822974
38PLK10.99121005
39MAP3K80.97829886
40WNK10.96119870
41BUB10.95108909
42ERBB40.88982886
43PINK10.88206996
44RET0.86322595
45TNK20.85943453
46CHEK20.85508919
47PIM10.85292413
48BMPR1B0.84789977
49TGFBR10.84230732
50CDK190.80328632
51CSNK1G30.79453391
52MARK30.78879173
53MUSK0.78618172
54TIE10.77110753
55BRD40.76164119
56TLK10.75208334
57MAP3K40.73836513
58STK390.73825817
59LRRK20.72628123
60BRSK20.71571903
61PTK20.71555677
62CSNK1G20.71368936
63CAMK1D0.70760419
64PAK60.70685949
65NEK20.68776127
66NEK90.68707468
67KSR10.67291277
68CSNK1A1L0.66204148
69SRPK10.64757027
70TYRO30.63190709
71STK30.61678031
72NEK10.58870452
73TESK20.58196622
74VRK10.57856128
75EEF2K0.56896462
76PRKD20.56633815
77PRKG10.53329108
78HIPK20.52836709
79MAPK130.51401992
80AURKB0.51321314
81AURKA0.51260942
82NTRK30.50339507
83MTOR0.49888474
84PRKCZ0.48244972
85ATR0.44078880
86ABL20.42150238
87CDK40.41902938
88PKN10.40924408
89PRKAA10.39836505
90NME10.36885198
91MAP2K70.36813459
92PKN20.36333942
93STK380.35466480
94CHUK0.34815500
95PLK20.33530298
96PBK0.33098616
97MAPKAPK30.32493278
98EPHA30.32049549
99CDK50.31962381
100CAMK1G0.31777948
101SGK4940.31748147
102SGK2230.31748147
103SGK20.31009221
104DMPK0.30522498
105PRKACA0.30399180
106OXSR10.30282460
107EPHA40.27441576
108GSK3B0.27254281
109TRIB30.26233271
110ACVR1B0.23426989
111PRKAA20.22852155
112MARK20.21673770
113ROCK20.21144322
114EIF2AK10.19620690
115MAPK100.18735707
116PDK10.18349401
117TRPM70.18080927
118AKT20.17916154
119CSNK1D0.17516147
120MAP2K40.17241548
121MAP3K10.17183202
122PLK30.16710370
123ATM0.16615981
124ROCK10.15855077
125KIT0.15637932
126CAMK2A0.15468418
127ABL10.15400990
128FLT30.15265824
129MAPKAPK50.14125586
130MAPK110.13990536
131CDK10.13837819
132NTRK20.12625943
133CLK10.12286363
134CDK70.11291178
135CHEK10.10784752
136MAP2K10.10616351
137SGK10.09873002
138SGK30.09446517
139PDK40.08704799
140PDK30.08704799
141CDK20.08662298
142MAP3K50.07557457
143ADRBK10.07328904
144PAK10.07147148
145MAP3K70.04333464
146AKT10.03930208
147CSNK1A10.03895670
148MAPK10.03654590
149PRKACB0.03637584
150CSNK1E0.01889689
151PRKCQ0.01568545

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047103.89653216
2Oocyte meiosis_Homo sapiens_hsa041143.82752764
3* Ovarian steroidogenesis_Homo sapiens_hsa049133.81205740
4Cell cycle_Homo sapiens_hsa041103.77700156
5RNA degradation_Homo sapiens_hsa030183.68022185
6Basal transcription factors_Homo sapiens_hsa030223.31183198
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049143.18952292
8Caffeine metabolism_Homo sapiens_hsa002322.91574712
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46417346
10Linoleic acid metabolism_Homo sapiens_hsa005912.42363668
11Dorso-ventral axis formation_Homo sapiens_hsa043202.40788321
12Ether lipid metabolism_Homo sapiens_hsa005652.36458601
13Pancreatic cancer_Homo sapiens_hsa052122.21708993
14Cysteine and methionine metabolism_Homo sapiens_hsa002702.18337600
15Non-homologous end-joining_Homo sapiens_hsa034502.15642634
16Base excision repair_Homo sapiens_hsa034102.02356245
17MicroRNAs in cancer_Homo sapiens_hsa052061.91976369
18Folate biosynthesis_Homo sapiens_hsa007901.88977039
19TGF-beta signaling pathway_Homo sapiens_hsa043501.75611274
20GnRH signaling pathway_Homo sapiens_hsa049121.68670939
21Fanconi anemia pathway_Homo sapiens_hsa034601.66837063
22Phototransduction_Homo sapiens_hsa047441.50403331
23DNA replication_Homo sapiens_hsa030301.43375260
24p53 signaling pathway_Homo sapiens_hsa041151.40803230
25Vitamin B6 metabolism_Homo sapiens_hsa007501.29513599
26Long-term depression_Homo sapiens_hsa047301.27651747
27Homologous recombination_Homo sapiens_hsa034401.24251505
28Inositol phosphate metabolism_Homo sapiens_hsa005621.21931792
29ABC transporters_Homo sapiens_hsa020101.16023005
30Nicotine addiction_Homo sapiens_hsa050331.13539522
31Choline metabolism in cancer_Homo sapiens_hsa052311.13160558
32Colorectal cancer_Homo sapiens_hsa052101.09748983
33RNA transport_Homo sapiens_hsa030131.08296813
34mRNA surveillance pathway_Homo sapiens_hsa030151.08072308
35Notch signaling pathway_Homo sapiens_hsa043301.04747340
36Prolactin signaling pathway_Homo sapiens_hsa049171.03358886
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02393177
38VEGF signaling pathway_Homo sapiens_hsa043700.97201533
39Taste transduction_Homo sapiens_hsa047420.93435143
40GABAergic synapse_Homo sapiens_hsa047270.93012216
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.91735685
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90315493
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89638425
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88130316
45Morphine addiction_Homo sapiens_hsa050320.86864947
46FoxO signaling pathway_Homo sapiens_hsa040680.86143824
47Huntingtons disease_Homo sapiens_hsa050160.85553296
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84087321
49Complement and coagulation cascades_Homo sapiens_hsa046100.82727658
50Hippo signaling pathway_Homo sapiens_hsa043900.82217866
51Bile secretion_Homo sapiens_hsa049760.81339059
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77459612
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76751010
54Adherens junction_Homo sapiens_hsa045200.76692106
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75816077
56Nucleotide excision repair_Homo sapiens_hsa034200.75738335
57Purine metabolism_Homo sapiens_hsa002300.73975380
58Thyroid cancer_Homo sapiens_hsa052160.72311527
59Ras signaling pathway_Homo sapiens_hsa040140.71768673
60Glutamatergic synapse_Homo sapiens_hsa047240.71703157
61MAPK signaling pathway_Homo sapiens_hsa040100.68813505
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66707743
63Regulation of autophagy_Homo sapiens_hsa041400.64940185
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.64493002
65Synaptic vesicle cycle_Homo sapiens_hsa047210.64335804
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63618422
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63187296
68Fatty acid elongation_Homo sapiens_hsa000620.61175535
69Vitamin digestion and absorption_Homo sapiens_hsa049770.59970344
70RNA polymerase_Homo sapiens_hsa030200.59213076
71mTOR signaling pathway_Homo sapiens_hsa041500.58789604
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58475897
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58064002
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55456990
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55105312
76Estrogen signaling pathway_Homo sapiens_hsa049150.54368693
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.53224497
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52851883
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52570420
80Chronic myeloid leukemia_Homo sapiens_hsa052200.51945531
81Renal cell carcinoma_Homo sapiens_hsa052110.51684589
82Spliceosome_Homo sapiens_hsa030400.50641361
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50026604
84Gap junction_Homo sapiens_hsa045400.48249514
85Serotonergic synapse_Homo sapiens_hsa047260.47190851
86Herpes simplex infection_Homo sapiens_hsa051680.45853666
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43569863
88Bladder cancer_Homo sapiens_hsa052190.42491438
89Wnt signaling pathway_Homo sapiens_hsa043100.42302499
90HTLV-I infection_Homo sapiens_hsa051660.41829162
91Olfactory transduction_Homo sapiens_hsa047400.41271423
92Oxytocin signaling pathway_Homo sapiens_hsa049210.40445175
93Endometrial cancer_Homo sapiens_hsa052130.39683329
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39513918
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.38503151
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38125496
97Hedgehog signaling pathway_Homo sapiens_hsa043400.38114235
98Glucagon signaling pathway_Homo sapiens_hsa049220.37698198
99Lysine degradation_Homo sapiens_hsa003100.37567436
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37265648
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35350001
102Pyrimidine metabolism_Homo sapiens_hsa002400.34940545
103Small cell lung cancer_Homo sapiens_hsa052220.34857133
104Mismatch repair_Homo sapiens_hsa034300.34510160
105Arachidonic acid metabolism_Homo sapiens_hsa005900.33876075
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.32986590
107Arginine biosynthesis_Homo sapiens_hsa002200.32889926
108Viral carcinogenesis_Homo sapiens_hsa052030.31788657
109Ribosome_Homo sapiens_hsa030100.31617979
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31511465
111Cardiac muscle contraction_Homo sapiens_hsa042600.31227288
112Non-small cell lung cancer_Homo sapiens_hsa052230.31078520
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30866262
114Glioma_Homo sapiens_hsa052140.28497871
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28159964
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.28143727
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.26630703
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25535473
119cAMP signaling pathway_Homo sapiens_hsa040240.25328015
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25203774
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25159698
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25150808
123Propanoate metabolism_Homo sapiens_hsa006400.24803821
124ErbB signaling pathway_Homo sapiens_hsa040120.24568157
125Tight junction_Homo sapiens_hsa045300.24349324
126Long-term potentiation_Homo sapiens_hsa047200.23005790
127Pyruvate metabolism_Homo sapiens_hsa006200.22031090
128Shigellosis_Homo sapiens_hsa051310.20239027
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19378532
130Cholinergic synapse_Homo sapiens_hsa047250.19034584
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17404263
132Protein digestion and absorption_Homo sapiens_hsa049740.15727082
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.14841470
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.14009743
135Circadian entrainment_Homo sapiens_hsa047130.13833536
136Parkinsons disease_Homo sapiens_hsa050120.13755776
137Phagosome_Homo sapiens_hsa041450.11181964
138Collecting duct acid secretion_Homo sapiens_hsa049660.10934472
139Arginine and proline metabolism_Homo sapiens_hsa003300.07764156
140Insulin secretion_Homo sapiens_hsa049110.07593345
141Metabolic pathways_Homo sapiens_hsa011000.06926093
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.04172466
143Calcium signaling pathway_Homo sapiens_hsa040200.04047433
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.01208798

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