GDI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.58083052
2synaptic vesicle exocytosis (GO:0016079)5.52013122
3vocalization behavior (GO:0071625)5.24244484
4regulation of synaptic vesicle exocytosis (GO:2000300)5.15625141
5sodium ion export (GO:0071436)5.14988681
6synaptic vesicle maturation (GO:0016188)5.09151577
7neuron cell-cell adhesion (GO:0007158)5.04210790
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.00883657
9glutamate secretion (GO:0014047)4.97773337
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.92809801
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86149905
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.80555907
13locomotory exploration behavior (GO:0035641)4.73080751
14regulation of glutamate receptor signaling pathway (GO:1900449)4.68399354
15protein localization to synapse (GO:0035418)4.60927798
16regulation of synaptic vesicle transport (GO:1902803)4.52171056
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.50950453
18neurotransmitter secretion (GO:0007269)4.42360537
19neurotransmitter-gated ion channel clustering (GO:0072578)4.35162681
20neuronal ion channel clustering (GO:0045161)4.32000174
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.13208409
22L-amino acid import (GO:0043092)4.00495286
23synaptic transmission, glutamatergic (GO:0035249)3.93770847
24neuronal action potential propagation (GO:0019227)3.93756862
25regulation of synapse structural plasticity (GO:0051823)3.93716212
26exploration behavior (GO:0035640)3.92360234
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.92069607
28neuron-neuron synaptic transmission (GO:0007270)3.91238221
29presynaptic membrane assembly (GO:0097105)3.88091394
30establishment of mitochondrion localization (GO:0051654)3.87688481
31amino acid import (GO:0043090)3.87387935
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.82856999
33positive regulation of synapse maturation (GO:0090129)3.82481708
34postsynaptic membrane organization (GO:0001941)3.81832035
35regulation of neuronal synaptic plasticity (GO:0048168)3.78516911
36neuromuscular process controlling balance (GO:0050885)3.76784526
37glutamate receptor signaling pathway (GO:0007215)3.75360294
38presynaptic membrane organization (GO:0097090)3.74970589
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74094188
40regulation of ARF protein signal transduction (GO:0032012)3.73242770
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69007366
42neuron recognition (GO:0008038)3.68030122
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.67096184
44cell communication by electrical coupling (GO:0010644)3.66957421
45gamma-aminobutyric acid transport (GO:0015812)3.66929685
46potassium ion homeostasis (GO:0055075)3.64240236
47axon ensheathment in central nervous system (GO:0032291)3.63485445
48central nervous system myelination (GO:0022010)3.63485445
49neurotransmitter transport (GO:0006836)3.54832990
50layer formation in cerebral cortex (GO:0021819)3.52623188
51cerebellar Purkinje cell differentiation (GO:0021702)3.51275587
52proline transport (GO:0015824)3.50925117
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48362928
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.48224441
55long-term synaptic potentiation (GO:0060291)3.47103264
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.43007964
57regulation of neurotransmitter secretion (GO:0046928)3.38811505
58dendritic spine organization (GO:0097061)3.38155889
59positive regulation of membrane potential (GO:0045838)3.37707597
60positive regulation of dendritic spine development (GO:0060999)3.37172265
61axonal fasciculation (GO:0007413)3.36792999
62establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.36764678
63mitochondrion transport along microtubule (GO:0047497)3.36764678
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36302664
65regulation of postsynaptic membrane potential (GO:0060078)3.35822555
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.34340930
67cerebellar granule cell differentiation (GO:0021707)3.33956627
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.33386057
69synaptic vesicle endocytosis (GO:0048488)3.33369969
70long-term memory (GO:0007616)3.31337773
71G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.31022613
72potassium ion import (GO:0010107)3.29686551
73negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.28340488
74regulation of neurotransmitter levels (GO:0001505)3.27639194
75activation of protein kinase A activity (GO:0034199)3.27127547
76regulation of synaptic plasticity (GO:0048167)3.23907626
77cytoskeletal anchoring at plasma membrane (GO:0007016)3.18668065
78regulation of vesicle fusion (GO:0031338)3.17177817
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17070145
80startle response (GO:0001964)3.16581081
81regulation of neurotransmitter transport (GO:0051588)3.16443357
82auditory behavior (GO:0031223)3.16249522
83cerebellar Purkinje cell layer development (GO:0021680)3.16136636
84mechanosensory behavior (GO:0007638)3.15069851
85regulation of voltage-gated calcium channel activity (GO:1901385)3.14569928
86positive regulation of synapse assembly (GO:0051965)3.13889530
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12982062
88positive regulation of neurotransmitter transport (GO:0051590)3.12158697
89regulation of synaptic transmission, GABAergic (GO:0032228)3.09837438
90cell migration in hindbrain (GO:0021535)3.09502602
91positive regulation of dendritic spine morphogenesis (GO:0061003)3.09461823
92regulation of synapse maturation (GO:0090128)3.09212897
93neuromuscular process controlling posture (GO:0050884)3.07894065
94response to auditory stimulus (GO:0010996)3.06994351
95mating behavior (GO:0007617)3.05974731
96cellular sodium ion homeostasis (GO:0006883)3.03809475
97synapse assembly (GO:0007416)3.03643240
98adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.01713558
99response to histamine (GO:0034776)3.01452222
100transmission of nerve impulse (GO:0019226)3.01342334
101membrane hyperpolarization (GO:0060081)2.99453140
102positive regulation of synaptic transmission (GO:0050806)2.99158606
103dendritic spine morphogenesis (GO:0060997)2.98942426
104cellular potassium ion homeostasis (GO:0030007)2.98911436
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97672129
106dendrite morphogenesis (GO:0048813)2.97552267
107innervation (GO:0060384)2.96831455
108pyrimidine nucleobase catabolic process (GO:0006208)2.96398858
109behavioral defense response (GO:0002209)2.96277722
110behavioral fear response (GO:0001662)2.96277722
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96230422
112membrane depolarization during action potential (GO:0086010)2.95873868
113membrane depolarization (GO:0051899)2.95515983
114transferrin transport (GO:0033572)2.94281806
115positive regulation of neurotransmitter secretion (GO:0001956)2.93879259
116synaptic transmission (GO:0007268)2.93395766
117dopamine receptor signaling pathway (GO:0007212)2.93364900
118learning (GO:0007612)2.93357336
119regulation of respiratory system process (GO:0044065)2.92656354
120regulation of dendritic spine morphogenesis (GO:0061001)2.92230110
121regulation of synaptic transmission (GO:0050804)2.89966828
122negative regulation of microtubule polymerization (GO:0031115)2.89725754
123energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.88240381
124ATP hydrolysis coupled proton transport (GO:0015991)2.88240381
125synaptic vesicle transport (GO:0048489)2.87952942
126establishment of synaptic vesicle localization (GO:0097480)2.87952942
127cell differentiation in hindbrain (GO:0021533)2.87655921
128negative regulation of dendrite morphogenesis (GO:0050774)2.86008938
129neuromuscular synaptic transmission (GO:0007274)2.85669787
130fear response (GO:0042596)2.81816698
131neuromuscular process (GO:0050905)2.80645227
132response to pheromone (GO:0019236)2.79785838
133negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77130312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.83433423
2GBX2_23144817_ChIP-Seq_PC3_Human4.04489719
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.25625965
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13074452
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96887180
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87523577
7REST_21632747_ChIP-Seq_MESCs_Mouse2.75823205
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56970570
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56970570
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55154606
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54879963
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.53495798
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50872125
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48724486
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48390832
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43643327
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38377385
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36939249
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.35694965
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34903948
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.34729671
22KDM2B_26808549_Chip-Seq_K562_Human2.27986995
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.27460703
24DROSHA_22980978_ChIP-Seq_HELA_Human2.23048221
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19984978
26TAF15_26573619_Chip-Seq_HEK293_Human2.19665947
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.19368525
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14667893
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.09864151
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98946434
31LXR_22292898_ChIP-Seq_THP-1_Human1.95414837
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92384125
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92252632
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86114529
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81999669
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73650659
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73629230
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73463846
39AR_21572438_ChIP-Seq_LNCaP_Human1.71923544
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71401172
41SMAD4_21799915_ChIP-Seq_A2780_Human1.70948055
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63551262
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63174194
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60675930
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59933611
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55387759
47CTCF_27219007_Chip-Seq_Bcells_Human1.54157540
48P300_19829295_ChIP-Seq_ESCs_Human1.53468240
49KDM2B_26808549_Chip-Seq_DND41_Human1.51963275
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49364282
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46556230
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45223241
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44058870
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.43839855
55TET1_21490601_ChIP-Seq_MESCs_Mouse1.41099667
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39096821
57ZNF274_21170338_ChIP-Seq_K562_Hela1.38544329
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.36899397
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.35004034
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34520932
61IGF1R_20145208_ChIP-Seq_DFB_Human1.34251311
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33998108
63RNF2_27304074_Chip-Seq_NSC_Mouse1.33422801
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.32530847
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31853560
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.30567055
67AR_25329375_ChIP-Seq_VCAP_Human1.29463241
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28956096
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.28948393
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27950795
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27705312
72SMC4_20622854_ChIP-Seq_HELA_Human1.27388430
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27285741
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.25727742
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.25364213
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25223831
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25013246
78STAT3_23295773_ChIP-Seq_U87_Human1.23731762
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21714115
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.19470569
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19226977
82CREB1_26743006_Chip-Seq_LNCaP_Human1.18374659
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17970917
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17576272
85AR_19668381_ChIP-Seq_PC3_Human1.17505178
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17215310
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.16333802
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15245982
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14249176
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.13392742
91P68_20966046_ChIP-Seq_HELA_Human1.11953366
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11218071
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10265973
94TCF4_23295773_ChIP-Seq_U87_Human1.09111587
95AHR_22903824_ChIP-Seq_MCF-7_Human1.07617141
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07493502
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07010958
98* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06782210
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.05559336
100OCT4_19829295_ChIP-Seq_ESCs_Human1.05276200
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04178460
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03813918
103RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03524973
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02566977
105RUNX2_22187159_ChIP-Seq_PCA_Human1.02307908
106TCF7_22412390_ChIP-Seq_EML_Mouse1.01183620
107ER_23166858_ChIP-Seq_MCF-7_Human1.00723929
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00447740
109SA1_27219007_Chip-Seq_ERYTHROID_Human0.98932674
110VDR_22108803_ChIP-Seq_LS180_Human0.98473598
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.98235602
112FUS_26573619_Chip-Seq_HEK293_Human0.98214392
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.97894744
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96665571
115RING1B_27294783_Chip-Seq_NPCs_Mouse0.96242520
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96158744
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96141760
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95873945
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95873945
120RACK7_27058665_Chip-Seq_MCF-7_Human0.95154340
121TRIM28_21343339_ChIP-Seq_HEK293_Human0.94714060
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93745328
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92950709
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92729244
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92686993
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92420138
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92365374
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91576656
129JUN_21703547_ChIP-Seq_K562_Human0.91268424
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.91068175
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.90741764
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90452125
133TP53_23651856_ChIP-Seq_MEFs_Mouse0.90444781
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90225915
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88158637
136KLF4_19829295_ChIP-Seq_ESCs_Human0.87091759
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.86874661
138SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86233368
139TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85887128
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85175701
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84643262
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84213485
143DPY_21335234_ChIP-Seq_ESCs_Mouse0.83616446
144* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83474218
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.83103765
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83062400
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80786214
148SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80530227
149* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79810476
150PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79390198
151NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76792615
152SOX3_22085726_ChIP-Seq_NPCs_Mouse0.76599803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.48300242
2MP0003880_abnormal_central_pattern4.60424576
3* MP0003635_abnormal_synaptic_transmissio3.85278225
4MP0004270_analgesia3.48623881
5* MP0009745_abnormal_behavioral_response3.18861374
6* MP0002063_abnormal_learning/memory/cond3.14036037
7MP0009046_muscle_twitch3.09886147
8* MP0002064_seizures3.06862135
9MP0001968_abnormal_touch/_nociception3.06536084
10MP0005423_abnormal_somatic_nervous2.75707236
11* MP0002572_abnormal_emotion/affect_behav2.74695613
12MP0002734_abnormal_mechanical_nocicepti2.64282612
13MP0002272_abnormal_nervous_system2.57271250
14MP0002822_catalepsy2.53268284
15MP0002736_abnormal_nociception_after2.51237229
16MP0002735_abnormal_chemical_nociception2.43370060
17MP0001486_abnormal_startle_reflex2.34501878
18MP0006276_abnormal_autonomic_nervous2.21394880
19MP0003122_maternal_imprinting2.20122551
20MP0003787_abnormal_imprinting2.14898805
21MP0009780_abnormal_chondrocyte_physiolo2.10709902
22MP0005646_abnormal_pituitary_gland2.10452876
23MP0002733_abnormal_thermal_nociception2.09422586
24MP0001501_abnormal_sleep_pattern2.08429130
25MP0002067_abnormal_sensory_capabilities2.06051578
26MP0001970_abnormal_pain_threshold1.99899301
27MP0001440_abnormal_grooming_behavior1.99158404
28MP0001984_abnormal_olfaction1.96253790
29MP0002184_abnormal_innervation1.96205465
30MP0000778_abnormal_nervous_system1.95766374
31MP0005645_abnormal_hypothalamus_physiol1.92962684
32MP0003690_abnormal_glial_cell1.84785449
33MP0002909_abnormal_adrenal_gland1.83963149
34MP0001529_abnormal_vocalization1.81083238
35MP0008569_lethality_at_weaning1.79054605
36MP0003123_paternal_imprinting1.77771177
37* MP0002557_abnormal_social/conspecific_i1.77181106
38MP0004924_abnormal_behavior1.76821450
39MP0005386_behavior/neurological_phenoty1.76821450
40MP0004811_abnormal_neuron_physiology1.75992033
41MP0004858_abnormal_nervous_system1.63472375
42MP0003879_abnormal_hair_cell1.61384624
43MP0000955_abnormal_spinal_cord1.53451209
44MP0003329_amyloid_beta_deposits1.45512374
45* MP0002882_abnormal_neuron_morphology1.45355520
46MP0001502_abnormal_circadian_rhythm1.43185505
47MP0002066_abnormal_motor_capabilities/c1.40095674
48MP0004142_abnormal_muscle_tone1.38881574
49MP0001905_abnormal_dopamine_level1.38739568
50MP0001348_abnormal_lacrimal_gland1.35036448
51MP0001188_hyperpigmentation1.33817317
52MP0000604_amyloidosis1.28206225
53MP0004885_abnormal_endolymph1.23495875
54MP0005409_darkened_coat_color1.23209958
55MP0000013_abnormal_adipose_tissue1.22746981
56MP0003183_abnormal_peptide_metabolism1.22422941
57MP0003633_abnormal_nervous_system1.20927329
58MP0010386_abnormal_urinary_bladder1.17872145
59MP0002837_dystrophic_cardiac_calcinosis1.12619305
60MP0005394_taste/olfaction_phenotype1.11307711
61MP0005499_abnormal_olfactory_system1.11307711
62* MP0002152_abnormal_brain_morphology1.09624531
63MP0000751_myopathy1.09608993
64MP0005551_abnormal_eye_electrophysiolog1.07908333
65MP0003631_nervous_system_phenotype1.03815297
66MP0002069_abnormal_eating/drinking_beha1.01690738
67MP0005623_abnormal_meninges_morphology1.01598613
68MP0002876_abnormal_thyroid_physiology1.00931800
69MP0002229_neurodegeneration1.00155564
70MP0000631_abnormal_neuroendocrine_gland0.96305577
71MP0003172_abnormal_lysosome_physiology0.96253025
72MP0002638_abnormal_pupillary_reflex0.95302187
73MP0004742_abnormal_vestibular_system0.91404990
74MP0000569_abnormal_digit_pigmentation0.90969277
75MP0003121_genomic_imprinting0.90098584
76MP0002249_abnormal_larynx_morphology0.88121978
77MP0002653_abnormal_ependyma_morphology0.87263790
78MP0004085_abnormal_heartbeat0.87036988
79MP0001963_abnormal_hearing_physiology0.84648954
80MP0002752_abnormal_somatic_nervous0.84598088
81MP0003634_abnormal_glial_cell0.83809376
82MP0008872_abnormal_physiological_respon0.82635734
83MP0004233_abnormal_muscle_weight0.82134306
84MP0003705_abnormal_hypodermis_morpholog0.81111656
85MP0004510_myositis0.80407577
86MP0001986_abnormal_taste_sensitivity0.79157636
87MP0003075_altered_response_to0.79033861
88MP0004130_abnormal_muscle_cell0.76687403
89MP0002751_abnormal_autonomic_nervous0.75944732
90MP0008874_decreased_physiological_sensi0.74452206
91MP0001664_abnormal_digestion0.74255620
92MP0008961_abnormal_basal_metabolism0.74080834
93MP0005535_abnormal_body_temperature0.72733679
94MP0000579_abnormal_nail_morphology0.71995194
95MP0001299_abnormal_eye_distance/0.70648526
96MP0003632_abnormal_nervous_system0.69512851
97MP0002089_abnormal_postnatal_growth/wei0.68939003
98MP0004043_abnormal_pH_regulation0.68867323
99MP0005167_abnormal_blood-brain_barrier0.66894312
100MP0004145_abnormal_muscle_electrophysio0.66054760
101MP0006072_abnormal_retinal_apoptosis0.65156526
102MP0001177_atelectasis0.64691877
103MP0000026_abnormal_inner_ear0.64462296
104MP0000534_abnormal_ureter_morphology0.64281831
105MP0004215_abnormal_myocardial_fiber0.63284366
106MP0003938_abnormal_ear_development0.63186149
107MP0005171_absent_coat_pigmentation0.62125933
108MP0001943_abnormal_respiration0.61765774
109MP0001346_abnormal_lacrimal_gland0.61309756
110MP0008789_abnormal_olfactory_epithelium0.59959973
111MP0010768_mortality/aging0.59164454
112MP0003137_abnormal_impulse_conducting0.59144247
113MP0003861_abnormal_nervous_system0.57621771
114MP0010770_preweaning_lethality0.57490317
115MP0002082_postnatal_lethality0.57490317
116MP0000920_abnormal_myelination0.56453512
117MP0010769_abnormal_survival0.56101184
118MP0005253_abnormal_eye_physiology0.55523058
119MP0003283_abnormal_digestive_organ0.55378085
120MP0001485_abnormal_pinna_reflex0.54180232
121MP0002090_abnormal_vision0.53865927
122MP0002081_perinatal_lethality0.52787611
123MP0008260_abnormal_autophagy0.51514299
124MP0000747_muscle_weakness0.50187519
125MP0001849_ear_inflammation0.49438698

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.14370574
2Myokymia (HP:0002411)5.53717110
3Epileptic encephalopathy (HP:0200134)5.28033090
4Focal seizures (HP:0007359)5.20183965
5Atonic seizures (HP:0010819)4.89890350
6Febrile seizures (HP:0002373)4.56018163
7Neurofibrillary tangles (HP:0002185)4.55547429
8Visual hallucinations (HP:0002367)4.49904970
9Progressive cerebellar ataxia (HP:0002073)4.19058851
10Obstructive sleep apnea (HP:0002870)4.17119131
11Hyperventilation (HP:0002883)4.12307188
12Absence seizures (HP:0002121)4.04161856
13Dialeptic seizures (HP:0011146)3.65597175
14Generalized tonic-clonic seizures (HP:0002069)3.48578657
15Broad-based gait (HP:0002136)3.39746729
16Pheochromocytoma (HP:0002666)3.34087008
17Ankle clonus (HP:0011448)3.33088804
18Papilledema (HP:0001085)3.17483494
19Abnormal eating behavior (HP:0100738)3.16995184
20Action tremor (HP:0002345)3.14014653
21Limb dystonia (HP:0002451)3.13927384
22Insomnia (HP:0100785)3.13679210
23Abnormal hair whorl (HP:0010721)3.11509688
24Truncal ataxia (HP:0002078)3.11238545
25Failure to thrive in infancy (HP:0001531)3.06709726
26Annular pancreas (HP:0001734)3.05169148
27Polyphagia (HP:0002591)3.04244640
28Depression (HP:0000716)3.03299580
29Supranuclear gaze palsy (HP:0000605)3.02791217
30Peripheral hypomyelination (HP:0007182)2.99867450
31Neuroendocrine neoplasm (HP:0100634)2.99439640
32Neuronal loss in central nervous system (HP:0002529)2.98869791
33Poor eye contact (HP:0000817)2.97145144
34Impaired vibration sensation in the lower limbs (HP:0002166)2.94025411
35Gaze-evoked nystagmus (HP:0000640)2.91006917
36Excessive salivation (HP:0003781)2.81660502
37Drooling (HP:0002307)2.81660502
38Epileptiform EEG discharges (HP:0011182)2.80868013
39Impaired social interactions (HP:0000735)2.78608045
40Abnormal social behavior (HP:0012433)2.78608045
41Anxiety (HP:0000739)2.76157776
42Progressive inability to walk (HP:0002505)2.75426536
43Dysdiadochokinesis (HP:0002075)2.74360879
44Amblyopia (HP:0000646)2.69346807
45Intention tremor (HP:0002080)2.68536828
46Genetic anticipation (HP:0003743)2.67562617
47EEG with generalized epileptiform discharges (HP:0011198)2.66266205
48Apathy (HP:0000741)2.64223403
49Urinary bladder sphincter dysfunction (HP:0002839)2.63419494
50Hyperacusis (HP:0010780)2.62111799
51Gait imbalance (HP:0002141)2.60257685
52Scanning speech (HP:0002168)2.56203820
53Tetraplegia (HP:0002445)2.55535930
54Hypsarrhythmia (HP:0002521)2.53986942
55Dysmetria (HP:0001310)2.52789341
56Hand muscle atrophy (HP:0009130)2.51322052
57Distal upper limb amyotrophy (HP:0007149)2.48150935
58Upper limb amyotrophy (HP:0009129)2.48150935
59Spastic gait (HP:0002064)2.44530008
60Diminished motivation (HP:0000745)2.43019659
61Diplopia (HP:0000651)2.41297998
62Abnormality of binocular vision (HP:0011514)2.41297998
63Lower limb amyotrophy (HP:0007210)2.40714441
64Absent speech (HP:0001344)2.40703955
65Postural instability (HP:0002172)2.40049363
66Urinary urgency (HP:0000012)2.39726107
67Blue irides (HP:0000635)2.37108929
68Torticollis (HP:0000473)2.37041278
69Inability to walk (HP:0002540)2.36168916
70Mutism (HP:0002300)2.34246299
71Pointed chin (HP:0000307)2.33745076
72Protruding tongue (HP:0010808)2.33305718
73Specific learning disability (HP:0001328)2.32354111
74Abnormality of the corticospinal tract (HP:0002492)2.30936515
75Turricephaly (HP:0000262)2.28772946
76Agitation (HP:0000713)2.28768284
77Cerebral hypomyelination (HP:0006808)2.28083522
78Hypoventilation (HP:0002791)2.27286853
79Impaired smooth pursuit (HP:0007772)2.26543986
80Focal dystonia (HP:0004373)2.25126234
81Poor suck (HP:0002033)2.24854231
82Hemiparesis (HP:0001269)2.24399390
83Bradykinesia (HP:0002067)2.21119471
84Rapidly progressive (HP:0003678)2.20703261
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.20602559
86Clonus (HP:0002169)2.19891696
87Congenital primary aphakia (HP:0007707)2.17196750
88Insidious onset (HP:0003587)2.16129311
89Termporal pattern (HP:0011008)2.16129311
90Narrow nasal bridge (HP:0000446)2.15262548
91Hammertoe (HP:0001765)2.14939660
92Status epilepticus (HP:0002133)2.12088072
93Dysmetric saccades (HP:0000641)2.11070569
94Medial flaring of the eyebrow (HP:0010747)2.10078334
95Abnormality of the lower motor neuron (HP:0002366)2.08790843
96Nephrogenic diabetes insipidus (HP:0009806)2.08101799
97Spinal canal stenosis (HP:0003416)2.07753527
98Stereotypic behavior (HP:0000733)2.07648965
99Lower limb muscle weakness (HP:0007340)2.07400557
100Oligomenorrhea (HP:0000876)2.05511736
101Fetal akinesia sequence (HP:0001989)2.04697971
102Bronchomalacia (HP:0002780)2.02503465
103Craniofacial dystonia (HP:0012179)2.02423646
104Hyperthyroidism (HP:0000836)2.02122797
105Spastic tetraparesis (HP:0001285)2.01502334
106Rigidity (HP:0002063)2.00022104
107Hypercortisolism (HP:0001578)1.98203057
108Abnormality of ocular smooth pursuit (HP:0000617)1.97541206
109Sleep apnea (HP:0010535)1.96964801
110Impaired vibratory sensation (HP:0002495)1.95962854
111Menstrual irregularities (HP:0000858)1.95157328
112Delusions (HP:0000746)1.94072993
113Psychosis (HP:0000709)1.93897218
114Aplasia involving bones of the upper limbs (HP:0009823)1.93894853
115Aplasia of the phalanges of the hand (HP:0009802)1.93894853
116Aplasia involving bones of the extremities (HP:0009825)1.93894853
117Hypoplasia of the brainstem (HP:0002365)1.92827887
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92827887
119Generalized hypotonia (HP:0001290)1.91800475
120Gait ataxia (HP:0002066)1.91733841
121Foot dorsiflexor weakness (HP:0009027)1.90169105
122Neoplasm of the peripheral nervous system (HP:0100007)1.87810033
123Esotropia (HP:0000565)1.87789587
124Abnormality of pain sensation (HP:0010832)1.86814021
125Impaired pain sensation (HP:0007328)1.86814021
126Abnormality of the labia minora (HP:0012880)1.86057788
127Akinesia (HP:0002304)1.84231170
128Hemiplegia (HP:0002301)1.84125922
129Exotropia (HP:0000577)1.83039396
130Abnormality of salivation (HP:0100755)1.82672712
131Overriding aorta (HP:0002623)1.82385921
132Lower limb asymmetry (HP:0100559)1.82347281
133Shallow orbits (HP:0000586)1.82086032
134Generalized myoclonic seizures (HP:0002123)1.81861631
135Morphological abnormality of the pyramidal tract (HP:0002062)1.81554570
136Cerebral inclusion bodies (HP:0100314)1.81088902
137Elfin facies (HP:0004428)1.80994631
138Megalencephaly (HP:0001355)1.79698729
139Amyotrophic lateral sclerosis (HP:0007354)1.79526577
140Distal sensory impairment (HP:0002936)1.79182181
141Decreased motor nerve conduction velocity (HP:0003431)1.78986105
142Hyperparathyroidism (HP:0000843)1.73381886
143Abnormality of the foot musculature (HP:0001436)1.72925735
144Hypoplasia of the corpus callosum (HP:0002079)1.70655895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.02646380
2NTRK33.96978224
3MARK13.41202413
4MAP3K43.18774819
5MAP2K72.98505544
6MAP3K122.94879273
7MAP3K92.94831638
8EPHA42.92684240
9MINK12.48995164
10DAPK22.25621775
11CDK192.14212851
12NTRK22.09020742
13RIPK11.97086305
14MAP2K41.94794258
15TRIB31.90068671
16PRPF4B1.89661546
17SIK31.77185707
18PAK61.76417582
19DAPK11.71579886
20MAPK131.69337276
21PLK21.63028125
22LATS21.58911746
23KSR11.55006731
24CDK51.46965733
25GRK51.38946216
26AKT31.36736289
27UHMK11.34011706
28SGK2231.32280046
29SGK4941.32280046
30KSR21.31045976
31ICK1.31006160
32TNIK1.25391694
33NTRK11.24776350
34PRKD31.24218584
35PRKCG1.23046773
36ARAF1.22289510
37CAMKK11.21484464
38CCNB11.20711915
39CAMKK21.20311805
40OXSR11.15600392
41SGK21.12572725
42TESK11.10720969
43SIK21.09555973
44PHKG11.07141569
45PHKG21.07141569
46MAP3K111.03187390
47RIPK40.99045821
48WNK30.98414914
49CDK180.97975250
50BCR0.96686274
51CAMK2A0.96590864
52PNCK0.95004196
53CDK140.89469347
54CDK150.89377746
55CAMK2B0.89269513
56FES0.88717685
57CSNK1G20.83886950
58MAPK120.82540131
59ALK0.82474139
60SGK30.81881060
61PRKCH0.81183665
62SIK10.80826828
63PKN10.80411350
64DYRK1A0.79254171
65PDGFRA0.78521199
66MAP3K20.78161557
67TSSK60.77878455
68CDK11A0.77130752
69CAMK10.74768208
70TYRO30.74439635
71PRKCE0.72813119
72NEK60.70656890
73STK380.68930147
74MAPK100.67292879
75PAK30.66906937
76MARK20.66255300
77RET0.65442172
78ERBB30.63837144
79BRAF0.61821470
80DYRK1B0.59754709
81SGK10.58215453
82LIMK10.57175098
83PTK2B0.56360917
84STK110.55100070
85RPS6KA20.54465433
86DYRK20.53226037
87CAMK2D0.51799764
88CAMK1G0.51643630
89FER0.51179001
90BRSK10.50559857
91TAOK10.49734432
92PTK20.49006035
93EPHB20.48616640
94CAMK2G0.48504033
95FGFR20.48414061
96CAMK40.48153956
97CSNK1G30.48150591
98PRKCZ0.46918240
99MAP3K10.46738469
100CDC42BPA0.46363566
101PINK10.45802746
102ADRBK10.45234590
103PRKD20.45086515
104LMTK20.44842866
105ADRBK20.44368806
106ERBB20.44040568
107EPHB10.43651966
108BMPR20.43397161
109DDR20.42227820
110WNK10.42124191
111INSRR0.41350026
112MAP3K130.40203892
113MOS0.39276656
114FYN0.39274912
115RPS6KA30.38998376
116TNK20.38777673
117RAF10.37934382
118DAPK30.37872902
119ROCK20.37736946
120CAMK1D0.37576503
121MAP2K10.37087390
122NME10.36455389
123PDK10.35930591
124PDPK10.35180537

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.89627021
2Nicotine addiction_Homo sapiens_hsa050333.74471841
3GABAergic synapse_Homo sapiens_hsa047272.83697929
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72282115
5Olfactory transduction_Homo sapiens_hsa047402.67455322
6Circadian entrainment_Homo sapiens_hsa047132.60377017
7Collecting duct acid secretion_Homo sapiens_hsa049662.55394661
8Morphine addiction_Homo sapiens_hsa050322.54566793
9Glutamatergic synapse_Homo sapiens_hsa047242.38028709
10Long-term potentiation_Homo sapiens_hsa047202.32538093
11Amphetamine addiction_Homo sapiens_hsa050312.29341554
12Dopaminergic synapse_Homo sapiens_hsa047282.22161761
13Insulin secretion_Homo sapiens_hsa049112.08094398
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99000960
15Taste transduction_Homo sapiens_hsa047421.85870119
16Salivary secretion_Homo sapiens_hsa049701.85330935
17Cholinergic synapse_Homo sapiens_hsa047251.80197287
18Serotonergic synapse_Homo sapiens_hsa047261.78673627
19Vibrio cholerae infection_Homo sapiens_hsa051101.76014308
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75247953
21Cocaine addiction_Homo sapiens_hsa050301.68858049
22Long-term depression_Homo sapiens_hsa047301.66945484
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61172173
24Gastric acid secretion_Homo sapiens_hsa049711.57866751
25Renin secretion_Homo sapiens_hsa049241.56437193
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44124640
27Oxytocin signaling pathway_Homo sapiens_hsa049211.40953851
28Calcium signaling pathway_Homo sapiens_hsa040201.38561722
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33182071
30Gap junction_Homo sapiens_hsa045401.30960650
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28192549
32Axon guidance_Homo sapiens_hsa043601.21946578
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20636173
34GnRH signaling pathway_Homo sapiens_hsa049121.18506499
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17485464
36Type II diabetes mellitus_Homo sapiens_hsa049301.13097361
37cAMP signaling pathway_Homo sapiens_hsa040241.10387233
38Phototransduction_Homo sapiens_hsa047441.10138607
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09910038
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08011082
41ErbB signaling pathway_Homo sapiens_hsa040121.01803778
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01558319
43Estrogen signaling pathway_Homo sapiens_hsa049150.94937735
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90350503
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89538037
46Glioma_Homo sapiens_hsa052140.87763101
47Melanogenesis_Homo sapiens_hsa049160.85642793
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.82050859
49Cardiac muscle contraction_Homo sapiens_hsa042600.78821362
50Type I diabetes mellitus_Homo sapiens_hsa049400.77159498
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76646717
52Notch signaling pathway_Homo sapiens_hsa043300.76247486
53Bile secretion_Homo sapiens_hsa049760.75405293
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75176150
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72797268
56Vitamin B6 metabolism_Homo sapiens_hsa007500.69566080
57MAPK signaling pathway_Homo sapiens_hsa040100.67187628
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66144974
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65163551
60Oxidative phosphorylation_Homo sapiens_hsa001900.65139214
61Pancreatic secretion_Homo sapiens_hsa049720.64743588
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64209916
63Oocyte meiosis_Homo sapiens_hsa041140.64039178
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63117034
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63002844
66Rheumatoid arthritis_Homo sapiens_hsa053230.61875846
67Thyroid hormone synthesis_Homo sapiens_hsa049180.61242642
68Dilated cardiomyopathy_Homo sapiens_hsa054140.60955446
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.60440856
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59333334
71Ras signaling pathway_Homo sapiens_hsa040140.59021271
72Non-small cell lung cancer_Homo sapiens_hsa052230.58948999
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57279140
74Alcoholism_Homo sapiens_hsa050340.57235587
75Phagosome_Homo sapiens_hsa041450.57170064
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56277804
77AMPK signaling pathway_Homo sapiens_hsa041520.56216079
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56169871
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.56143589
80Circadian rhythm_Homo sapiens_hsa047100.55750920
81Glucagon signaling pathway_Homo sapiens_hsa049220.55240846
82Alzheimers disease_Homo sapiens_hsa050100.53413833
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53114959
84Choline metabolism in cancer_Homo sapiens_hsa052310.51666401
85Endometrial cancer_Homo sapiens_hsa052130.51651914
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50236947
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48747157
88Prolactin signaling pathway_Homo sapiens_hsa049170.47444206
89Salmonella infection_Homo sapiens_hsa051320.46847864
90Endocytosis_Homo sapiens_hsa041440.45563844
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45184911
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.44681792
93Rap1 signaling pathway_Homo sapiens_hsa040150.44494116
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43813634
95Insulin signaling pathway_Homo sapiens_hsa049100.43312035
96Inositol phosphate metabolism_Homo sapiens_hsa005620.43166111
97Chronic myeloid leukemia_Homo sapiens_hsa052200.42992333
98Hippo signaling pathway_Homo sapiens_hsa043900.42803890
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42291481
100Dorso-ventral axis formation_Homo sapiens_hsa043200.40586883
101Renal cell carcinoma_Homo sapiens_hsa052110.40388340
102Wnt signaling pathway_Homo sapiens_hsa043100.39145589
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38792176
104Colorectal cancer_Homo sapiens_hsa052100.38763629
105Parkinsons disease_Homo sapiens_hsa050120.38544244
106Regulation of autophagy_Homo sapiens_hsa041400.38505174
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38026654
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36712318
109VEGF signaling pathway_Homo sapiens_hsa043700.36432051
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35967435
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.35711517
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34697398
113Butanoate metabolism_Homo sapiens_hsa006500.34025766
114mTOR signaling pathway_Homo sapiens_hsa041500.33844301
115Prion diseases_Homo sapiens_hsa050200.33362643
116Ovarian steroidogenesis_Homo sapiens_hsa049130.31247949
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30808644
118Chemokine signaling pathway_Homo sapiens_hsa040620.29280756

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