GDI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.47855527
2double-strand break repair via nonhomologous end joining (GO:0006303)4.43530594
3non-recombinational repair (GO:0000726)4.43530594
4DNA ligation (GO:0006266)4.34730026
5establishment of viral latency (GO:0019043)4.22973787
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.02247421
7formation of translation preinitiation complex (GO:0001731)3.97762227
8DNA unwinding involved in DNA replication (GO:0006268)3.87135499
9DNA double-strand break processing (GO:0000729)3.75212104
10regulation of centriole replication (GO:0046599)3.72461447
11protein localization to kinetochore (GO:0034501)3.71861675
12Arp2/3 complex-mediated actin nucleation (GO:0034314)3.69704291
13mitotic spindle checkpoint (GO:0071174)3.63223654
14regulation of helicase activity (GO:0051095)3.60852474
15DNA topological change (GO:0006265)3.52850130
16histone exchange (GO:0043486)3.52232108
17DNA strand elongation involved in DNA replication (GO:0006271)3.51468603
18negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.48975351
19negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.48975351
20negative regulation of mitotic sister chromatid segregation (GO:0033048)3.48975351
21negative regulation of mitotic sister chromatid separation (GO:2000816)3.48975351
22negative regulation of sister chromatid segregation (GO:0033046)3.48975351
23COPI coating of Golgi vesicle (GO:0048205)3.48921598
24Golgi transport vesicle coating (GO:0048200)3.48921598
25negative regulation of chromosome segregation (GO:0051985)3.47959282
26mitotic nuclear envelope disassembly (GO:0007077)3.47883637
27folic acid-containing compound biosynthetic process (GO:0009396)3.44199164
28tRNA aminoacylation for protein translation (GO:0006418)3.41225752
29nuclear pore organization (GO:0006999)3.40854618
30IMP biosynthetic process (GO:0006188)3.38108455
31regulation of sister chromatid segregation (GO:0033045)3.36963500
32regulation of mitotic sister chromatid separation (GO:0010965)3.36963500
33regulation of mitotic sister chromatid segregation (GO:0033047)3.36963500
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36395567
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35973039
36mitotic spindle assembly checkpoint (GO:0007094)3.34978893
37amino acid activation (GO:0043038)3.33041394
38tRNA aminoacylation (GO:0043039)3.33041394
39L-serine metabolic process (GO:0006563)3.32930812
40response to X-ray (GO:0010165)3.31122183
41DNA strand elongation (GO:0022616)3.31022237
42membrane disassembly (GO:0030397)3.29472021
43nuclear envelope disassembly (GO:0051081)3.29472021
44nucleobase biosynthetic process (GO:0046112)3.23662912
45ATP-dependent chromatin remodeling (GO:0043044)3.22127717
46regulation of spindle organization (GO:0090224)3.20857695
47proteasome assembly (GO:0043248)3.19592510
48negative regulation of DNA recombination (GO:0045910)3.19188370
49protein localization to chromosome, centromeric region (GO:0071459)3.18097214
50purine nucleobase biosynthetic process (GO:0009113)3.18087117
51pre-miRNA processing (GO:0031054)3.16060231
52mitotic G2/M transition checkpoint (GO:0044818)3.15134783
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14771512
54ribosomal small subunit assembly (GO:0000028)3.13109687
55nuclear pore complex assembly (GO:0051292)3.13064047
56IMP metabolic process (GO:0046040)3.12629362
57telomere maintenance via semi-conservative replication (GO:0032201)3.10714348
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09254376
59negative regulation of ligase activity (GO:0051352)3.09254376
60B cell mediated immunity (GO:0019724)3.07973790
61DNA catabolic process, exonucleolytic (GO:0000738)3.04992309
62DNA strand renaturation (GO:0000733)3.04252441
63mitotic metaphase plate congression (GO:0007080)3.03530293
64telomere maintenance via recombination (GO:0000722)3.00493453
65mitotic recombination (GO:0006312)2.99362534
66establishment of chromosome localization (GO:0051303)2.97678182
67cullin deneddylation (GO:0010388)2.97470431
68mitotic chromosome condensation (GO:0007076)2.97201626
69isotype switching (GO:0045190)2.95834854
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.95834854
71somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.95834854
72DNA replication initiation (GO:0006270)2.95512472
73regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.94548224
74regulation of mitotic spindle checkpoint (GO:1903504)2.94548224
75DNA damage response, detection of DNA damage (GO:0042769)2.93954625
76somatic recombination of immunoglobulin gene segments (GO:0016447)2.93693145
77pinocytosis (GO:0006907)2.92319818
78antigen processing and presentation of endogenous antigen (GO:0019883)2.91016952
79histone-serine phosphorylation (GO:0035404)2.89640487
80attachment of spindle microtubules to kinetochore (GO:0008608)2.88942650
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88732929
82regulation of translational termination (GO:0006449)2.85727259
83DNA replication checkpoint (GO:0000076)2.84244013
84regulation of protein heterodimerization activity (GO:0043497)2.81078957
85pore complex assembly (GO:0046931)2.79361605
86positive regulation of interferon-alpha production (GO:0032727)2.76750415
87immunoglobulin mediated immune response (GO:0016064)2.75988919
88regulation of B cell receptor signaling pathway (GO:0050855)2.75223909
89actin nucleation (GO:0045010)2.73470274
90positive regulation of protein import into nucleus, translocation (GO:0033160)2.71569127
91regulation of mitotic spindle organization (GO:0060236)2.69704873
92metaphase plate congression (GO:0051310)2.64211005
93negative regulation of phagocytosis (GO:0050765)2.63562249
94sister chromatid segregation (GO:0000819)2.62701737
95regulation of interferon-alpha production (GO:0032647)2.58138210
96regulation of interferon-beta biosynthetic process (GO:0045357)2.58124107
97DNA replication-dependent nucleosome assembly (GO:0006335)2.57570251
98DNA replication-dependent nucleosome organization (GO:0034723)2.57570251
99postreplication repair (GO:0006301)2.56748337
100nuclear envelope organization (GO:0006998)2.54334460
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.52962908
102mitotic sister chromatid segregation (GO:0000070)2.52126501
103positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.52083805
104positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.52083805
105positive regulation of mitotic sister chromatid separation (GO:1901970)2.52083805
106somatic hypermutation of immunoglobulin genes (GO:0016446)2.51700398
107somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51700398
108positive regulation of SMAD protein import into nucleus (GO:0060391)2.50827926
109CENP-A containing nucleosome assembly (GO:0034080)2.50376859
110telomere maintenance via telomere lengthening (GO:0010833)2.49872207
111ribosome assembly (GO:0042255)2.47330803
112antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.45763638
113mitotic sister chromatid cohesion (GO:0007064)2.45727052
114antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.44976498
115antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.44976498
116DNA duplex unwinding (GO:0032508)2.43107778
117chromatin remodeling at centromere (GO:0031055)2.43055112
118DNA geometric change (GO:0032392)2.42452768
119dosage compensation (GO:0007549)2.41215130
120nucleotide-excision repair, DNA gap filling (GO:0006297)2.39586639
121regulation of mitotic metaphase/anaphase transition (GO:0030071)2.39047172
122neutrophil activation involved in immune response (GO:0002283)2.37950030
123DNA replication-independent nucleosome organization (GO:0034724)2.37499233
124DNA replication-independent nucleosome assembly (GO:0006336)2.37499233
125regulation of chromosome segregation (GO:0051983)2.37205006
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.36926492
127positive regulation by organism of defense response of other organism involved in symbiotic interact2.36926492
128modulation by symbiont of host immune response (GO:0052553)2.36926492
129positive regulation by symbiont of host defense response (GO:0052509)2.36926492
130modulation by symbiont of host defense response (GO:0052031)2.36926492
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.36926492
132positive regulation of chromosome segregation (GO:0051984)2.36546194
133regulation of SMAD protein import into nucleus (GO:0060390)2.36197538
134regulation of sister chromatid cohesion (GO:0007063)2.35834058
135antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.33539593
136protein localization to chromosome (GO:0034502)2.33229545
137kinetochore organization (GO:0051383)2.31905154
138translesion synthesis (GO:0019985)2.30891303
139chaperone mediated protein folding requiring cofactor (GO:0051085)2.30448663
140regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.30285924
141spindle assembly checkpoint (GO:0071173)2.30122411
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.28522781
143regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.27817356
144positive regulation of lamellipodium assembly (GO:0010592)2.27719673
145spindle checkpoint (GO:0031577)2.27291222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.81656177
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.91393758
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.54228602
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27041416
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.08108038
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00449882
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.66739922
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.55572875
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55386485
10AR_21909140_ChIP-Seq_LNCAP_Human2.32233878
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.20100890
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18868109
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12392180
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07095560
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01601445
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99575413
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98330181
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97308148
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95855982
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95479894
21* MYC_22102868_ChIP-Seq_BL_Human1.94397021
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.93399767
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.90524227
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89489173
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88781304
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87767988
27* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83551723
28* E2F1_21310950_ChIP-Seq_MCF-7_Human1.77745893
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75741339
30XRN2_22483619_ChIP-Seq_HELA_Human1.74790564
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67451663
32VDR_23849224_ChIP-Seq_CD4+_Human1.67243722
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65938142
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65231260
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63587206
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62826548
37* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62298492
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61403343
39SPI1_23547873_ChIP-Seq_NB4_Human1.61196608
40ELK1_19687146_ChIP-ChIP_HELA_Human1.59785154
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59372303
42DCP1A_22483619_ChIP-Seq_HELA_Human1.58816583
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.58525995
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55958278
45TFEB_21752829_ChIP-Seq_HELA_Human1.52491429
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50635771
47* IRF8_27001747_Chip-Seq_BMDM_Mouse1.49874775
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48683459
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47821271
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46811748
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46504047
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45948272
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45513876
54* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45101018
55FOXP3_21729870_ChIP-Seq_TREG_Human1.42207587
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40891346
57CLOCK_20551151_ChIP-Seq_293T_Human1.40739715
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40203120
59* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39637752
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37994427
61GABP_19822575_ChIP-Seq_HepG2_Human1.37097166
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36334442
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35584059
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35552193
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33619805
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33452769
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32005800
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.31299318
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30040063
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29070520
71MYB_26560356_Chip-Seq_TH2_Human1.27111980
72TTF2_22483619_ChIP-Seq_HELA_Human1.26162760
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25905031
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22905050
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20753428
76* KDM5A_27292631_Chip-Seq_BREAST_Human1.20193944
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19822312
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.19690792
79* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19017673
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18886552
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17905714
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16346650
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15965468
84VDR_21846776_ChIP-Seq_THP-1_Human1.15449866
85CIITA_25753668_ChIP-Seq_RAJI_Human1.14424841
86MYC_18940864_ChIP-ChIP_HL60_Human1.14280346
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13499593
88* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13041475
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12047489
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11854635
91EWS_26573619_Chip-Seq_HEK293_Human1.11557214
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10067960
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.09805713
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06315558
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05773181
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04788960
97* MYB_26560356_Chip-Seq_TH1_Human1.04190162
98* MAF_26560356_Chip-Seq_TH1_Human1.02410447
99* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02186976
100* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01266059
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.01001807
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.00396610
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99772546
104TP63_17297297_ChIP-ChIP_HaCaT_Human0.99052202
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97673260
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97208455
107* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95639353
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.95514581
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94815755
110FUS_26573619_Chip-Seq_HEK293_Human0.94802683
111TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94224675
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93527098
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92798335
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92739280
115IRF1_19129219_ChIP-ChIP_H3396_Human0.91952949
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90559881
117UTX_26944678_Chip-Seq_JUKART_Human0.90385337
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90275196
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88154508
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87000588
121* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85993530
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84809905
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84363197
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84303508
125PU_27001747_Chip-Seq_BMDM_Mouse0.84279100
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82726121
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82515194
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.82390402
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82367667
130VDR_24763502_ChIP-Seq_THP-1_Human0.82325978
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81832816
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81432384
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.80178088
134TP63_19390658_ChIP-ChIP_HaCaT_Human0.76883923
135IGF1R_20145208_ChIP-Seq_DFB_Human0.76332848
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76218813
137EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75464956
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74568774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.13462024
2MP0003941_abnormal_skin_development3.09934165
3MP0003693_abnormal_embryo_hatching2.84782525
4MP0010352_gastrointestinal_tract_polyps2.81677742
5MP0004957_abnormal_blastocyst_morpholog2.62807732
6MP0006054_spinal_hemorrhage2.42423700
7MP0003705_abnormal_hypodermis_morpholog2.40086799
8MP0010094_abnormal_chromosome_stability2.38799021
9MP0003077_abnormal_cell_cycle2.36559444
10MP0003718_maternal_effect2.25963015
11MP0003890_abnormal_embryonic-extraembry2.24733993
12MP0008007_abnormal_cellular_replicative2.07802199
13MP0003436_decreased_susceptibility_to2.07042820
14MP0008438_abnormal_cutaneous_collagen2.06417871
15MP0003111_abnormal_nucleus_morphology2.02492286
16MP0010307_abnormal_tumor_latency1.95189220
17MP0001293_anophthalmia1.92040978
18MP0002396_abnormal_hematopoietic_system1.85852918
19MP0008057_abnormal_DNA_replication1.80542463
20MP0003566_abnormal_cell_adhesion1.79840633
21MP0003303_peritoneal_inflammation1.77277609
22MP0005076_abnormal_cell_differentiation1.76991665
23MP0009672_abnormal_birth_weight1.71147879
24MP0002452_abnormal_antigen_presenting1.68929730
25MP0002254_reproductive_system_inflammat1.67016478
26MP0003300_gastrointestinal_ulcer1.59182268
27MP0001800_abnormal_humoral_immune1.58447787
28MP0001730_embryonic_growth_arrest1.57872241
29MP0005058_abnormal_lysosome_morphology1.57164340
30MP0002148_abnormal_hypersensitivity_rea1.53572802
31MP0000490_abnormal_crypts_of1.51297491
32MP0008877_abnormal_DNA_methylation1.51088250
33MP0009333_abnormal_splenocyte_physiolog1.50926220
34MP0002419_abnormal_innate_immunity1.48930578
35MP0000685_abnormal_immune_system1.48733575
36MP0003123_paternal_imprinting1.48469695
37MP0005000_abnormal_immune_tolerance1.48448222
38MP0004808_abnormal_hematopoietic_stem1.47810137
39MP0002085_abnormal_embryonic_tissue1.47046449
40MP0000350_abnormal_cell_proliferation1.44525574
41MP0010234_abnormal_vibrissa_follicle1.44063531
42MP0009785_altered_susceptibility_to1.42266841
43MP0003786_premature_aging1.41343423
44MP0001819_abnormal_immune_cell1.40842148
45MP0002420_abnormal_adaptive_immunity1.39679162
46MP0000858_altered_metastatic_potential1.39553274
47MP0005464_abnormal_platelet_physiology1.36610185
48MP0002166_altered_tumor_susceptibility1.35817399
49MP0002398_abnormal_bone_marrow1.34463921
50MP0008932_abnormal_embryonic_tissue1.33874378
51MP0005671_abnormal_response_to1.33809245
52MP0005023_abnormal_wound_healing1.32226816
53MP0002009_preneoplasia1.31999903
54MP0002796_impaired_skin_barrier1.30946520
55MP0005025_abnormal_response_to1.30810702
56MP0003937_abnormal_limbs/digits/tail_de1.28052746
57MP0002723_abnormal_immune_serum1.27696746
58MP0003121_genomic_imprinting1.24272368
59MP0001286_abnormal_eye_development1.24270885
60MP0000689_abnormal_spleen_morphology1.23332515
61MP0003448_altered_tumor_morphology1.23230468
62MP0000647_abnormal_sebaceous_gland1.22138667
63MP0006292_abnormal_olfactory_placode1.19243424
64MP0006082_CNS_inflammation1.19214418
65MP0002722_abnormal_immune_system1.18398641
66MP0002697_abnormal_eye_size1.17906853
67MP0002019_abnormal_tumor_incidence1.17577677
68MP0000716_abnormal_immune_system1.16916389
69MP0002405_respiratory_system_inflammati1.16810150
70MP0010155_abnormal_intestine_physiology1.16794032
71MP0002006_tumorigenesis1.16626440
72MP0005275_abnormal_skin_tensile1.15611026
73MP0002877_abnormal_melanocyte_morpholog1.15455621
74MP0008789_abnormal_olfactory_epithelium1.15150466
75MP0001853_heart_inflammation1.15063123
76MP0001697_abnormal_embryo_size1.14824154
77MP0001915_intracranial_hemorrhage1.13741586
78MP0010678_abnormal_skin_adnexa1.13672608
79MP0002429_abnormal_blood_cell1.13519681
80MP0001790_abnormal_immune_system1.13238245
81MP0005387_immune_system_phenotype1.13238245
82MP0001533_abnormal_skeleton_physiology1.12984523
83MP0001545_abnormal_hematopoietic_system1.10976090
84MP0005397_hematopoietic_system_phenotyp1.10976090
85MP0001845_abnormal_inflammatory_respons1.10560047
86MP0005501_abnormal_skin_physiology1.10063833
87MP0001666_abnormal_nutrient_absorption1.08789151
88MP0006035_abnormal_mitochondrial_morpho1.08661173
89MP0003191_abnormal_cellular_cholesterol1.08558184
90MP0009053_abnormal_anal_canal1.08068776
91MP0003984_embryonic_growth_retardation1.07808675
92MP0002086_abnormal_extraembryonic_tissu1.07520896
93MP0002088_abnormal_embryonic_growth/wei1.07069577
94MP0005380_embryogenesis_phenotype1.04797269
95MP0001672_abnormal_embryogenesis/_devel1.04797269
96MP0009703_decreased_birth_body1.04576992
97MP0006072_abnormal_retinal_apoptosis1.03196400
98MP0005394_taste/olfaction_phenotype1.03059201
99MP0005499_abnormal_olfactory_system1.03059201
100MP0003315_abnormal_perineum_morphology1.01466233
101MP0002080_prenatal_lethality1.00894506
102MP0004782_abnormal_surfactant_physiolog1.00827954
103MP0000343_altered_response_to1.00396459
104MP0008058_abnormal_DNA_repair1.00123194
105MP0003183_abnormal_peptide_metabolism0.99377003
106MP0002233_abnormal_nose_morphology0.98509994
107MP0005408_hypopigmentation0.95877339
108MP0003186_abnormal_redox_activity0.95238034
109MP0003806_abnormal_nucleotide_metabolis0.94547257
110MP0000537_abnormal_urethra_morphology0.93610348
111MP0002111_abnormal_tail_morphology0.93051951
112MP0002138_abnormal_hepatobiliary_system0.91259250
113MP0001881_abnormal_mammary_gland0.91100336
114MP0004947_skin_inflammation0.90703654
115MP0005248_abnormal_Harderian_gland0.90694725
116MP0000465_gastrointestinal_hemorrhage0.90508067
117MP0003763_abnormal_thymus_physiology0.90453171
118MP0001958_emphysema0.89850382
119MP0000313_abnormal_cell_death0.89474210
120MP0002092_abnormal_eye_morphology0.88327903
121MP0003567_abnormal_fetal_cardiomyocyte0.87595703
122MP0001849_ear_inflammation0.86787070
123MP0000598_abnormal_liver_morphology0.85906652
124MP0004197_abnormal_fetal_growth/weight/0.84838213
125MP0004264_abnormal_extraembryonic_tissu0.84630498
126MP0004272_abnormal_basement_membrane0.84041781
127MP0000703_abnormal_thymus_morphology0.83813245
128MP0005384_cellular_phenotype0.83377623
129MP0000428_abnormal_craniofacial_morphol0.83178767
130MP0003119_abnormal_digestive_system0.81605728
131MP0002751_abnormal_autonomic_nervous0.81505337
132MP0008469_abnormal_protein_level0.79692258
133MP0003279_aneurysm0.78568346
134MP0001727_abnormal_embryo_implantation0.77267600
135MP0000377_abnormal_hair_follicle0.77150992
136MP0001661_extended_life_span0.76362557
137MP0002938_white_spotting0.76316568
138MP0010030_abnormal_orbit_morphology0.76309687
139MP0003868_abnormal_feces_composition0.75930344
140MP0009840_abnormal_foam_cell0.75618768
141MP0005395_other_phenotype0.74813759
142MP0009697_abnormal_copulation0.74123164
143MP0003221_abnormal_cardiomyocyte_apopto0.74064220
144MP0002084_abnormal_developmental_patter0.73005423
145MP0000358_abnormal_cell_content/0.72714755
146MP0000371_diluted_coat_color0.72232578
147MP0000427_abnormal_hair_cycle0.71840053
148MP0000477_abnormal_intestine_morphology0.69314027
149MP0010368_abnormal_lymphatic_system0.68275966
150MP0000627_abnormal_mammary_gland0.67764556
151MP0001216_abnormal_epidermal_layer0.66686745
152MP0001119_abnormal_female_reproductive0.66117091
153MP0005621_abnormal_cell_physiology0.64866804
154MP0001243_abnormal_dermal_layer0.64007974
155MP0003950_abnormal_plasma_membrane0.63695143
156MP0000383_abnormal_hair_follicle0.62055299
157MP0001145_abnormal_male_reproductive0.60798464
158MP0001929_abnormal_gametogenesis0.60611797
159MP0001529_abnormal_vocalization0.60505689

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.03526705
2Chromsome breakage (HP:0040012)3.86857815
3Agnosia (HP:0010524)3.59641288
4Nephroblastoma (Wilms tumor) (HP:0002667)3.56033241
5Abnormality of chromosome stability (HP:0003220)3.46136340
6Rhabdomyosarcoma (HP:0002859)3.42970183
7Thrombocytosis (HP:0001894)3.42590500
8Embryonal renal neoplasm (HP:0011794)3.38846506
9Degeneration of anterior horn cells (HP:0002398)3.36931193
10Abnormality of the anterior horn cell (HP:0006802)3.36931193
11Recurrent abscess formation (HP:0002722)3.22822176
12Abnormal lung lobation (HP:0002101)3.21862346
13Eczematoid dermatitis (HP:0000976)3.10088043
14Increased cerebral lipofuscin (HP:0011813)3.09797217
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.08264855
16Increased serum pyruvate (HP:0003542)3.02465045
17Abnormality of methionine metabolism (HP:0010901)3.01154318
18Abnormality of the labia minora (HP:0012880)2.99854506
19Recurrent bacterial skin infections (HP:0005406)2.97682233
20Abnormality of glycolysis (HP:0004366)2.93343829
21Medulloblastoma (HP:0002885)2.92800165
22Meckel diverticulum (HP:0002245)2.85312602
23Abnormality of aspartate family amino acid metabolism (HP:0010899)2.84081805
24Hematochezia (HP:0002573)2.76277779
25Ependymoma (HP:0002888)2.72205962
26Abnormality of the ileum (HP:0001549)2.69467332
27IgM deficiency (HP:0002850)2.69104373
28Abnormality of the preputium (HP:0100587)2.64190777
29Disinhibition (HP:0000734)2.61360810
30Cervical subluxation (HP:0003308)2.60735530
31Systemic lupus erythematosus (HP:0002725)2.58016260
32Papillary thyroid carcinoma (HP:0002895)2.55833197
33Volvulus (HP:0002580)2.53922155
34Poor head control (HP:0002421)2.52464540
35Gonadotropin excess (HP:0000837)2.51368926
36Increased nuchal translucency (HP:0010880)2.50168948
37Colon cancer (HP:0003003)2.46569872
38Duodenal stenosis (HP:0100867)2.45495509
39Small intestinal stenosis (HP:0012848)2.45495509
40Abnormality of complement system (HP:0005339)2.40018462
41Breast carcinoma (HP:0003002)2.39060364
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.38903469
43Myositis (HP:0100614)2.38485259
44Recurrent gram-negative bacterial infections (HP:0005420)2.35576510
45Microvesicular hepatic steatosis (HP:0001414)2.33231658
46Myelodysplasia (HP:0002863)2.30119555
47Protrusio acetabuli (HP:0003179)2.29411825
48Vacuolated lymphocytes (HP:0001922)2.28719151
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.28537675
50Osteolytic defects of the hand bones (HP:0009699)2.28537675
51Cortical dysplasia (HP:0002539)2.27773128
52Cellulitis (HP:0100658)2.27325202
53Mucosal telangiectasiae (HP:0100579)2.26621297
54Thyroid carcinoma (HP:0002890)2.26391464
55Stenosis of the external auditory canal (HP:0000402)2.26124878
56Deep philtrum (HP:0002002)2.25882838
57Pancreatic islet-cell hyperplasia (HP:0004510)2.25817216
58Abnormality of the duodenum (HP:0002246)2.22629940
59Birth length less than 3rd percentile (HP:0003561)2.20124893
60Oral leukoplakia (HP:0002745)2.19613897
61Malignant gastrointestinal tract tumors (HP:0006749)2.18545485
62Gastrointestinal carcinoma (HP:0002672)2.18545485
63Autoimmune thrombocytopenia (HP:0001973)2.17772527
64Aortic aneurysm (HP:0004942)2.14940946
65Biliary tract neoplasm (HP:0100574)2.14325886
66Ovarian neoplasm (HP:0100615)2.11045835
67Supernumerary spleens (HP:0009799)2.09527245
68Cutaneous melanoma (HP:0012056)2.09258163
69Abnormality of serum amino acid levels (HP:0003112)2.08242733
70Aplasia/hypoplasia of the humerus (HP:0006507)2.05430924
71Elevated erythrocyte sedimentation rate (HP:0003565)2.04094353
72Horseshoe kidney (HP:0000085)2.02775471
73Spinal cord lesions (HP:0100561)2.02568865
74Syringomyelia (HP:0003396)2.02568865
75Osteomyelitis (HP:0002754)2.02429679
76Recurrent viral infections (HP:0004429)2.02091622
77Spinal muscular atrophy (HP:0007269)2.01965475
78Interstitial pulmonary disease (HP:0006530)2.00447310
79Neoplasm of the colon (HP:0100273)2.00412671
80Intrahepatic cholestasis (HP:0001406)2.00210259
81Hypobetalipoproteinemia (HP:0003563)2.00181911
82Insidious onset (HP:0003587)1.99752790
83Termporal pattern (HP:0011008)1.99752790
84Spontaneous hematomas (HP:0007420)1.95905303
85Glioma (HP:0009733)1.95646533
86Neoplasm of the adrenal gland (HP:0100631)1.93927433
87Neoplasm of the rectum (HP:0100743)1.93619366
88Hypoplastic pelvis (HP:0008839)1.92717052
89Multiple enchondromatosis (HP:0005701)1.92544990
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.91390288
91Embryonal neoplasm (HP:0002898)1.89620303
92Sloping forehead (HP:0000340)1.89347889
93Increased hepatocellular lipid droplets (HP:0006565)1.88622485
94Abnormality of the vasculature of the conjunctiva (HP:0008054)1.88617796
95Cerebral aneurysm (HP:0004944)1.88568703
96Curly hair (HP:0002212)1.88392105
97Posterior subcapsular cataract (HP:0007787)1.87873075
98Neoplasm of striated muscle (HP:0009728)1.86909910
99Spastic diplegia (HP:0001264)1.86508675
100Glomerulonephritis (HP:0000099)1.86110656
101Abnormality of macrophages (HP:0004311)1.85701157
102Vertebral compression fractures (HP:0002953)1.85508752
103Short humerus (HP:0005792)1.85055942
104Ascites (HP:0001541)1.84892293
105Pustule (HP:0200039)1.83191532
106Bifid tongue (HP:0010297)1.82213531
107Lymphoma (HP:0002665)1.81878032
108Leiomyosarcoma (HP:0100243)1.81876736
109Uterine leiomyosarcoma (HP:0002891)1.81876736
110Metaphyseal cupping (HP:0003021)1.81231778
111Aplastic anemia (HP:0001915)1.81037728
112Bile duct proliferation (HP:0001408)1.80665287
113Abnormal biliary tract physiology (HP:0012439)1.80665287
114Abnormal foot bone ossification (HP:0010675)1.80452882
115Postnatal microcephaly (HP:0005484)1.79137055
116Progressive external ophthalmoplegia (HP:0000590)1.78790906
117Microglossia (HP:0000171)1.78708929
118Reticulocytopenia (HP:0001896)1.78626562
119Obstructive lung disease (HP:0006536)1.78583487
120Chronic obstructive pulmonary disease (HP:0006510)1.78583487
121Intestinal atresia (HP:0011100)1.78288978
122Hepatoblastoma (HP:0002884)1.77435263
123Adrenal hypoplasia (HP:0000835)1.77074596
124Periodontitis (HP:0000704)1.76943195
125Choanal atresia (HP:0000453)1.76892677
126Hyperglycinemia (HP:0002154)1.76796060
127Recurrent bronchitis (HP:0002837)1.75690801
128Abnormality of glycine metabolism (HP:0010895)1.75482974
129Abnormality of serine family amino acid metabolism (HP:0010894)1.75482974
130Lipid accumulation in hepatocytes (HP:0006561)1.74639382
131Cholecystitis (HP:0001082)1.74407152
132Abnormal gallbladder physiology (HP:0012438)1.74407152
133Secondary amenorrhea (HP:0000869)1.74066061
134Subacute progressive viral hepatitis (HP:0006572)1.74052025
135Hypoglycemic seizures (HP:0002173)1.73952912
136Ankle contracture (HP:0006466)1.73839222
137Transitional cell carcinoma of the bladder (HP:0006740)1.73654522
138High pitched voice (HP:0001620)1.73652926
139Symptomatic seizures (HP:0011145)1.73401714
140Increased mean platelet volume (HP:0011877)1.73141273
141Skull defect (HP:0001362)1.73091058
142Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72870713
143Diminished motivation (HP:0000745)1.72508258
144Amaurosis fugax (HP:0100576)1.72501228
145Orchitis (HP:0100796)1.72201385
146Arterial thrombosis (HP:0004420)1.72117371
147Deviation of the thumb (HP:0009603)1.71802230
148Absent radius (HP:0003974)1.71695596
149Abnormality of the calcaneus (HP:0008364)1.71459285
150Atrophy/Degeneration involving motor neurons (HP:0007373)1.71341744
151Abnormal platelet volume (HP:0011876)1.71274676
152Neoplasm of the small intestine (HP:0100833)1.70884863
153Abnormality of cells of the lymphoid lineage (HP:0012140)1.70807970
154Prominent metopic ridge (HP:0005487)1.70691921
155Dysostosis multiplex (HP:0000943)1.70347515
156Overlapping toe (HP:0001845)1.70195497
157Increased density of long bones (HP:0006392)1.69841608
158Carpal bone hypoplasia (HP:0001498)1.68903754
159IgA deficiency (HP:0002720)1.68864019
160Upper motor neuron abnormality (HP:0002127)1.68365940
161Abnormality of pyrimidine metabolism (HP:0004353)1.68235650
162Abnormality of the astrocytes (HP:0100707)1.67985292
163Astrocytoma (HP:0009592)1.67985292
164Recurrent pneumonia (HP:0006532)1.67718736
165Abnormality of T cell physiology (HP:0011840)1.67465959
166Personality changes (HP:0000751)1.66974607
167Striae distensae (HP:0001065)1.66864549
168Recurrent fungal infections (HP:0002841)1.66352967
169Mucopolysacchariduria (HP:0008155)1.65644747
170Urinary glycosaminoglycan excretion (HP:0003541)1.65644747
171Uterine neoplasm (HP:0010784)1.64863366
172Lymphopenia (HP:0001888)1.63292145
173Short 4th metacarpal (HP:0010044)1.62894667
174Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.62894667
175Selective tooth agenesis (HP:0001592)1.61582896
176Bicuspid aortic valve (HP:0001647)1.61067741
177Abnormality of the distal phalanges of the toes (HP:0010182)1.60593856
178Conjunctival telangiectasia (HP:0000524)1.60451311
179Aortic dissection (HP:0002647)1.59849994
180Abnormality of the lumbar spine (HP:0100712)1.59361931
181Mediastinal lymphadenopathy (HP:0100721)1.58788245
182Beaking of vertebral bodies (HP:0004568)1.58269635
183Abnormal neuron morphology (HP:0012757)1.58123925
184Abnormality of the motor neurons (HP:0002450)1.58123925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.35242607
2EIF2AK12.85452088
3CDC72.57483210
4BUB12.52807320
5SCYL22.50612047
6WEE12.46652826
7NEK12.44899660
8MKNK22.26845392
9NEK92.18216439
10STK102.15016740
11MAP4K12.07174354
12PKN22.06939102
13BRSK22.06903876
14TSSK62.06230803
15BCR2.04147872
16TGFBR12.01787083
17FLT32.00166515
18ACVR1B1.99158656
19RPS6KA41.97581235
20TAF11.88454581
21PLK41.87675038
22NEK21.86625979
23BLK1.82659730
24TGFBR21.76890840
25PASK1.72274774
26ZAK1.70174122
27EEF2K1.68787973
28LRRK21.66611927
29NUAK11.58521908
30PAK41.50580789
31CSF1R1.50140681
32ZAP701.40371193
33TYK21.40220148
34MAP3K121.38871299
35VRK21.38238907
36TESK11.37354051
37TESK21.37132325
38PLK31.36643128
39TRIB31.33278281
40ERN11.28971471
41PIM21.28199728
42MAP3K81.26323944
43CDK61.25216785
44EIF2AK31.23410814
45MAP2K31.22513749
46JAK31.20062516
47FRK1.17608127
48TBK11.17471393
49NME21.14243601
50SIK31.12472993
51TIE11.12059312
52RPS6KB21.09325782
53WNK31.08064109
54TTK1.07964986
55STK38L1.07626399
56STK161.07043017
57KIT1.06732217
58MST41.05788814
59PLK11.05554279
60MAP3K141.03738990
61AURKB1.02994256
62CDK191.01671622
63EIF2AK21.00445302
64CLK10.98701015
65CCNB10.94497882
66BTK0.94336540
67STK30.93770891
68PIM10.92972982
69BRD40.90414475
70PLK20.90178107
71PDK20.90150259
72ERBB30.88086170
73ATM0.88061011
74ATR0.87357053
75MKNK10.85460308
76BRSK10.84759345
77FGFR30.84536238
78CDK40.84226523
79PTK60.83008971
80TEC0.82558590
81MAPKAPK30.81897998
82ERBB40.79931557
83TNIK0.79555674
84KDR0.67778103
85MAP3K30.67476519
86SYK0.66408933
87CSNK1G10.66210181
88MAP3K40.65765735
89ALK0.64385737
90KSR10.61778289
91MAP3K100.61121401
92STK40.60482020
93ITK0.60158438
94SMG10.59175140
95SRPK10.58728684
96LYN0.58233580
97JAK10.57806202
98CHUK0.57430314
99IKBKB0.57211882
100MATK0.57133631
101MELK0.56256256
102BMPR1B0.55978295
103CSNK1G30.54624368
104CSK0.54210634
105IRAK40.54032196
106CDK80.54011168
107BRAF0.53765375
108MAP4K20.53400596
109YES10.52967511
110LIMK10.52755036
111CSNK2A20.52241061
112RIPK10.51868273
113PDK40.51703438
114PDK30.51703438
115CDK70.50555022
116DYRK30.50214972
117CSNK1E0.50095047
118PBK0.49350226
119STK240.48957853
120MAP3K50.48483816
121CDK180.47703386
122DAPK10.47572438
123CSNK1G20.47084925
124FGFR10.47041172
125CSNK2A10.46588685
126JAK20.45170758
127VRK10.44870020
128TAOK20.44330413
129CHEK10.44166693
130CSNK1A1L0.44118050
131BMPR20.43917634
132CDK10.43362951
133CHEK20.43324189
134LCK0.42796215
135FGFR40.42743523
136MARK30.42150345
137CDK20.41599456
138MAPKAPK20.41575490
139LATS10.40814747
140AURKA0.40705695
141CDK140.40067966
142EPHA20.38069626
143STK390.37862834
144TLK10.37497000
145OXSR10.36866671
146CDK150.34389557
147FER0.31734268
148BCKDK0.31708664
149PRKDC0.31663343
150CDK11A0.31191980
151ILK0.31046209

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.73249627
2Mismatch repair_Homo sapiens_hsa034303.06722132
3Proteasome_Homo sapiens_hsa030502.60977054
4Protein export_Homo sapiens_hsa030602.56681528
5Base excision repair_Homo sapiens_hsa034102.33649688
6One carbon pool by folate_Homo sapiens_hsa006702.26702191
7Cell cycle_Homo sapiens_hsa041102.25586732
8RNA transport_Homo sapiens_hsa030132.18260489
9Antigen processing and presentation_Homo sapiens_hsa046122.17933762
10Propanoate metabolism_Homo sapiens_hsa006402.13037922
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03961601
12Legionellosis_Homo sapiens_hsa051342.02611894
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00739553
14Spliceosome_Homo sapiens_hsa030401.95656772
15Steroid biosynthesis_Homo sapiens_hsa001001.92112269
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83937203
17Nucleotide excision repair_Homo sapiens_hsa034201.72416612
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.71926572
19Homologous recombination_Homo sapiens_hsa034401.56614054
20Pyruvate metabolism_Homo sapiens_hsa006201.56086052
21Leishmaniasis_Homo sapiens_hsa051401.53756668
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47471706
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45833541
24p53 signaling pathway_Homo sapiens_hsa041151.44236976
25Shigellosis_Homo sapiens_hsa051311.38395603
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36307121
27Epstein-Barr virus infection_Homo sapiens_hsa051691.35720490
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34629246
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29584296
30Lysosome_Homo sapiens_hsa041421.28695756
31Ribosome_Homo sapiens_hsa030101.25114778
32Staphylococcus aureus infection_Homo sapiens_hsa051501.24857480
33Pyrimidine metabolism_Homo sapiens_hsa002401.24273065
34Herpes simplex infection_Homo sapiens_hsa051681.23746420
35Fatty acid elongation_Homo sapiens_hsa000621.21806529
36Viral carcinogenesis_Homo sapiens_hsa052031.19133649
37Non-homologous end-joining_Homo sapiens_hsa034501.16953757
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.14400180
39Vitamin B6 metabolism_Homo sapiens_hsa007501.13385838
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12393144
41Apoptosis_Homo sapiens_hsa042101.11221504
42Pentose phosphate pathway_Homo sapiens_hsa000301.10470061
43RNA polymerase_Homo sapiens_hsa030201.08985688
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06157557
45Renin-angiotensin system_Homo sapiens_hsa046141.05603962
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03715501
47Other glycan degradation_Homo sapiens_hsa005111.02765405
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01537718
49B cell receptor signaling pathway_Homo sapiens_hsa046621.00116738
50Biosynthesis of amino acids_Homo sapiens_hsa012300.99349918
51Measles_Homo sapiens_hsa051620.99098624
52RNA degradation_Homo sapiens_hsa030180.98196055
53Osteoclast differentiation_Homo sapiens_hsa043800.96769527
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.95555558
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93998263
56Toxoplasmosis_Homo sapiens_hsa051450.93434491
57Pertussis_Homo sapiens_hsa051330.92849826
58Phagosome_Homo sapiens_hsa041450.90430591
59Tuberculosis_Homo sapiens_hsa051520.89217038
60Glutathione metabolism_Homo sapiens_hsa004800.89164114
61Chronic myeloid leukemia_Homo sapiens_hsa052200.88351164
62Hepatitis B_Homo sapiens_hsa051610.88087270
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88064791
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.87662213
65Primary immunodeficiency_Homo sapiens_hsa053400.86293759
66Influenza A_Homo sapiens_hsa051640.85596250
67Viral myocarditis_Homo sapiens_hsa054160.85240964
68Carbon metabolism_Homo sapiens_hsa012000.85132043
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84495251
70Thyroid cancer_Homo sapiens_hsa052160.83393175
71Selenocompound metabolism_Homo sapiens_hsa004500.83131816
72Pancreatic cancer_Homo sapiens_hsa052120.82962594
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81497287
74Small cell lung cancer_Homo sapiens_hsa052220.81396168
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.81227048
76HTLV-I infection_Homo sapiens_hsa051660.80848661
77Purine metabolism_Homo sapiens_hsa002300.79985327
78mRNA surveillance pathway_Homo sapiens_hsa030150.77684034
79N-Glycan biosynthesis_Homo sapiens_hsa005100.76098882
80Sulfur metabolism_Homo sapiens_hsa009200.73772389
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.71867912
82Salmonella infection_Homo sapiens_hsa051320.71299270
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70528092
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69627222
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68841483
86Systemic lupus erythematosus_Homo sapiens_hsa053220.68676498
87Colorectal cancer_Homo sapiens_hsa052100.68622029
88Adherens junction_Homo sapiens_hsa045200.68314228
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67646756
90MicroRNAs in cancer_Homo sapiens_hsa052060.65874860
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64872867
92Galactose metabolism_Homo sapiens_hsa000520.63925406
93Fatty acid metabolism_Homo sapiens_hsa012120.62568714
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62214243
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61810601
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61614028
97Basal transcription factors_Homo sapiens_hsa030220.58692459
98Asthma_Homo sapiens_hsa053100.57843878
99Fanconi anemia pathway_Homo sapiens_hsa034600.57491591
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56582446
101Proteoglycans in cancer_Homo sapiens_hsa052050.56382547
102Hematopoietic cell lineage_Homo sapiens_hsa046400.56254485
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.55660379
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55486952
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54860612
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54846947
107TNF signaling pathway_Homo sapiens_hsa046680.53609499
108Malaria_Homo sapiens_hsa051440.52649423
109Caffeine metabolism_Homo sapiens_hsa002320.51774444
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51717331
111Folate biosynthesis_Homo sapiens_hsa007900.51664238
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51291336
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.50089022
114HIF-1 signaling pathway_Homo sapiens_hsa040660.49961689
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49947116
116Fatty acid degradation_Homo sapiens_hsa000710.48061220
117TGF-beta signaling pathway_Homo sapiens_hsa043500.47671563
118Bladder cancer_Homo sapiens_hsa052190.46366159
119Peroxisome_Homo sapiens_hsa041460.46027411
120Fat digestion and absorption_Homo sapiens_hsa049750.45941354
121Platelet activation_Homo sapiens_hsa046110.43416258
122Oocyte meiosis_Homo sapiens_hsa041140.42577474
123Vitamin digestion and absorption_Homo sapiens_hsa049770.41013156
124Metabolic pathways_Homo sapiens_hsa011000.39822829
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39587067
126Lysine degradation_Homo sapiens_hsa003100.37351690
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.37349484
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35341017
129Alcoholism_Homo sapiens_hsa050340.31998010
130Tight junction_Homo sapiens_hsa045300.31691923
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31576656
132Starch and sucrose metabolism_Homo sapiens_hsa005000.31116016
133Hippo signaling pathway_Homo sapiens_hsa043900.30262312
134Butanoate metabolism_Homo sapiens_hsa006500.29582380
135Arginine and proline metabolism_Homo sapiens_hsa003300.28122889
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27933112
137Fructose and mannose metabolism_Homo sapiens_hsa000510.27855282
138beta-Alanine metabolism_Homo sapiens_hsa004100.20204431
139Wnt signaling pathway_Homo sapiens_hsa043100.19430267
140Arginine biosynthesis_Homo sapiens_hsa002200.15901002

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