ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell wall macromolecule metabolic process (GO:0044036)	9.10003947
2	interferon-gamma production (GO:0032609)	8.28410482
3	positive regulation of systemic arterial blood pressure (GO:0003084)	5.24217403
4	endocardial cushion morphogenesis (GO:0003203)	4.91804937
5	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	4.70072087
6	sequestering of actin monomers (GO:0042989)	4.48024294
7	regulation of urine volume (GO:0035809)	4.38475730
8	otic vesicle formation (GO:0030916)	4.23242370
9	protein neddylation (GO:0045116)	4.16929551
10	negative regulation of vascular permeability (GO:0043116)	3.82181553
11	dendritic spine morphogenesis (GO:0060997)	3.79696329
12	regulation of excretion (GO:0044062)	3.75888760
13	regulation of renal sodium excretion (GO:0035813)	3.71221047
14	DNA deamination (GO:0045006)	3.69486623
15	cullin deneddylation (GO:0010388)	3.63436294
16	telencephalon development (GO:0021537)	3.60484820
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.60374898
18	prostate gland growth (GO:0060736)	3.57959310
19	protein deneddylation (GO:0000338)	3.54867012
20	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.51254965
21	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.43450906
22	regulation of cardioblast proliferation (GO:0003264)	3.43450906
23	serotonin receptor signaling pathway (GO:0007210)	3.27669581
24	prenylation (GO:0097354)	3.26809514
25	protein prenylation (GO:0018342)	3.26809514
26	proteasome assembly (GO:0043248)	3.25594290
27	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.22350326
28	DNA double-strand break processing (GO:0000729)	3.21735135
29	cGMP metabolic process (GO:0046068)	3.10246971
30	AMP metabolic process (GO:0046033)	3.08798536
31	mesenchyme morphogenesis (GO:0072132)	3.05786342
32	digestive tract morphogenesis (GO:0048546)	3.05443063
33	ether lipid metabolic process (GO:0046485)	3.02084352
34	positive regulation of prostaglandin secretion (GO:0032308)	3.00630445
35	sleep (GO:0030431)	2.96089750
36	negative regulation of mast cell activation (GO:0033004)	2.95384392
37	cGMP biosynthetic process (GO:0006182)	2.94736806
38	rRNA methylation (GO:0031167)	2.92858646
39	vocalization behavior (GO:0071625)	2.92314007
40	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.87255602
41	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.86751459
42	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.86751459
43	histone H2A acetylation (GO:0043968)	2.81675495
44	positive regulation of blood pressure (GO:0045777)	2.81493043
45	positive regulation of vascular permeability (GO:0043117)	2.79068067
46	limb bud formation (GO:0060174)	2.77753775
47	seminiferous tubule development (GO:0072520)	2.77123914
48	organ growth (GO:0035265)	2.76871254
49	positive regulation of RNA splicing (GO:0033120)	2.76743407
50	presynaptic membrane assembly (GO:0097105)	2.76230643
51	protein peptidyl-prolyl isomerization (GO:0000413)	2.75324742
52	rRNA modification (GO:0000154)	2.74229328
53	protein import into peroxisome matrix (GO:0016558)	2.72705626
54	glycoprotein catabolic process (GO:0006516)	2.69189860
55	positive regulation of T-helper 1 type immune response (GO:0002827)	2.62546498
56	glycerol ether metabolic process (GO:0006662)	2.61231447
57	response to BMP (GO:0071772)	2.60251915
58	cellular response to BMP stimulus (GO:0071773)	2.60251915
59	adenosine metabolic process (GO:0046085)	2.59636483
60	axoneme assembly (GO:0035082)	2.59238515
61	nephron tubule formation (GO:0072079)	2.55481032
62	response to pheromone (GO:0019236)	2.54915890
63	microtubule polymerization or depolymerization (GO:0031109)	2.54596273
64	mesenchymal cell proliferation (GO:0010463)	2.53825027
65	fucose catabolic process (GO:0019317)	2.51958171
66	L-fucose metabolic process (GO:0042354)	2.51958171
67	L-fucose catabolic process (GO:0042355)	2.51958171
68	autophagic vacuole fusion (GO:0000046)	2.51317476
69	protein K63-linked deubiquitination (GO:0070536)	2.51098538
70	regulation of centriole replication (GO:0046599)	2.50120574
71	cardiac right ventricle morphogenesis (GO:0003215)	2.49870640
72	chromatin remodeling at centromere (GO:0031055)	2.49224042
73	positive regulation of fatty acid transport (GO:2000193)	2.48913072
74	forebrain neuron differentiation (GO:0021879)	2.48683345
75	positive regulation of defense response to virus by host (GO:0002230)	2.48101151
76	CENP-A containing nucleosome assembly (GO:0034080)	2.47577583
77	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.47494234
78	epithelial cell fate commitment (GO:0072148)	2.45952029
79	positive regulation of icosanoid secretion (GO:0032305)	2.45424875
80	ether metabolic process (GO:0018904)	2.45051278
81	lysine catabolic process (GO:0006554)	2.44385667
82	lysine metabolic process (GO:0006553)	2.44385667
83	organelle disassembly (GO:1903008)	2.44179518
84	regulation of prostaglandin secretion (GO:0032306)	2.42823290
85	valine metabolic process (GO:0006573)	2.42762208
86	activation of adenylate cyclase activity (GO:0007190)	2.42336939
87	myoblast migration (GO:0051451)	2.42049051
88	auditory behavior (GO:0031223)	2.40693609
89	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.36876451
90	monoubiquitinated protein deubiquitination (GO:0035520)	2.36867540
91	lung lobe morphogenesis (GO:0060463)	2.35881432
92	cGMP-mediated signaling (GO:0019934)	2.35448137
93	magnesium ion transport (GO:0015693)	2.34207244
94	negative regulation of neurological system process (GO:0031645)	2.33830824
95	intracellular protein transmembrane import (GO:0044743)	2.33234952
96	cellular response to interferon-beta (GO:0035458)	2.32610018
97	rRNA catabolic process (GO:0016075)	2.32534124
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.31655415
99	inner ear receptor stereocilium organization (GO:0060122)	2.31175126
100	cell wall macromolecule catabolic process (GO:0016998)	10.7879338

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.98056000
2	VDR_22108803_ChIP-Seq_LS180_Human	3.81207784
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.73038412
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.13983985
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.04291397
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.82098696
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.73061616
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.60828914
9	FUS_26573619_Chip-Seq_HEK293_Human	2.55560379
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.45471889
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.43511145
12	GATA1_22025678_ChIP-Seq_K562_Human	2.43281248
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41119951
14	EWS_26573619_Chip-Seq_HEK293_Human	2.24832783
15	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.24766181
16	P300_19829295_ChIP-Seq_ESCs_Human	2.06715057
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00833774
18	GBX2_23144817_ChIP-Seq_PC3_Human	2.00250137
19	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.92914941
20	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.90641412
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87642181
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.76321437
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.73183938
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.72269999
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.72050964
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71347701
27	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.70596412
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68378601
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.67566264
30	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.64862590
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63255723
32	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.62629545
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.56310433
34	AR_21572438_ChIP-Seq_LNCaP_Human	1.54874383
35	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.52775972
36	AR_20517297_ChIP-Seq_VCAP_Human	1.50146338
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.50046927
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49856101
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.49117606
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47699551
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46814686
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42991963
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42991963
44	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42947343
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38519986
46	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.38146033
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37116526
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36862104
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.36830920
50	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36441297
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36208032
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.34174955
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33583503
54	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27372945
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27343471
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.27343471
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.25801965
58	TP53_16413492_ChIP-PET_HCT116_Human	1.25619589
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.25244376
60	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.22622233
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22607197
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21884697
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18727016
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18683884
65	EZH2_22144423_ChIP-Seq_EOC_Human	1.18431006
66	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.15940554
67	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.15778751
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14081523
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13796141
70	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.12995518
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12600709
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12431613
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12431613
74	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12197819
75	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12197819
76	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.10094521
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09582348
78	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09500599
79	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.09290719
80	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07768473
81	TCF4_23295773_ChIP-Seq_U87_Human	1.07598270
82	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.07577764
83	STAT3_23295773_ChIP-Seq_U87_Human	1.07108588
84	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07064705
85	TP53_22573176_ChIP-Seq_HFKS_Human	1.06550769
86	BCAT_22108803_ChIP-Seq_LS180_Human	1.06315533
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06161881
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04964587
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.04600988
90	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.03601670
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03305265
92	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02141550
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01935031
94	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00954413
95	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00649506
96	P300_18555785_Chip-Seq_ESCs_Mouse	1.00095677
97	AR_25329375_ChIP-Seq_VCAP_Human	0.99683603
98	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98930634
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98041932
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.97131182

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.54340399
2	MP0000566_synostosis	3.61881101
3	MP0006072_abnormal_retinal_apoptosis	3.54997230
4	MP0003806_abnormal_nucleotide_metabolis	3.12084264
5	MP0009384_cardiac_valve_regurgitation	2.71981812
6	MP0005084_abnormal_gallbladder_morpholo	2.59136734
7	MP0002138_abnormal_hepatobiliary_system	2.51701257
8	MP0003121_genomic_imprinting	2.42802859
9	MP0005167_abnormal_blood-brain_barrier	2.32484659
10	MP0001986_abnormal_taste_sensitivity	2.30875848
11	MP0000372_irregular_coat_pigmentation	2.20482981
12	MP0008775_abnormal_heart_ventricle	2.12837555
13	MP0003122_maternal_imprinting	2.08312776
14	MP0010368_abnormal_lymphatic_system	2.01962070
15	MP0006054_spinal_hemorrhage	1.89375218
16	MP0004215_abnormal_myocardial_fiber	1.89329634
17	MP0004084_abnormal_cardiac_muscle	1.86487952
18	MP0004484_altered_response_of	1.82355597
19	MP0002102_abnormal_ear_morphology	1.81903437
20	MP0003567_abnormal_fetal_cardiomyocyte	1.81122033
21	MP0005253_abnormal_eye_physiology	1.76877010
22	MP0002282_abnormal_trachea_morphology	1.74771999
23	MP0008877_abnormal_DNA_methylation	1.72169818
24	MP0005671_abnormal_response_to	1.70675821
25	MP0009697_abnormal_copulation	1.63181600
26	MP0003136_yellow_coat_color	1.61479382
27	MP0002837_dystrophic_cardiac_calcinosis	1.60830496
28	MP0004142_abnormal_muscle_tone	1.56334253
29	MP0001873_stomach_inflammation	1.52093287
30	MP0009780_abnormal_chondrocyte_physiolo	1.51297583
31	MP0001835_abnormal_antigen_presentation	1.50669820
32	MP0003221_abnormal_cardiomyocyte_apopto	1.49128932
33	MP0003880_abnormal_central_pattern	1.47900293
34	MP0001984_abnormal_olfaction	1.46350662
35	MP0003724_increased_susceptibility_to	1.42971404
36	MP0008875_abnormal_xenobiotic_pharmacok	1.34547425
37	MP0003137_abnormal_impulse_conducting	1.33910600
38	MP0008872_abnormal_physiological_respon	1.33862926
39	MP0002653_abnormal_ependyma_morphology	1.32907388
40	MP0005551_abnormal_eye_electrophysiolog	1.29729533
41	MP0006138_congestive_heart_failure	1.28553071
42	MP0005365_abnormal_bile_salt	1.27874510
43	MP0003172_abnormal_lysosome_physiology	1.26660067
44	MP0002933_joint_inflammation	1.22911894
45	MP0001661_extended_life_span	1.20609690
46	MP0004043_abnormal_pH_regulation	1.17039963
47	MP0002751_abnormal_autonomic_nervous	1.13192181
48	MP0005645_abnormal_hypothalamus_physiol	1.12900283
49	MP0008961_abnormal_basal_metabolism	1.12828314
50	MP0002638_abnormal_pupillary_reflex	1.12586756
51	MP0000631_abnormal_neuroendocrine_gland	1.06553236
52	MP0005385_cardiovascular_system_phenoty	1.06383072
53	MP0001544_abnormal_cardiovascular_syste	1.06383072
54	MP0009785_altered_susceptibility_to	1.04195418
55	MP0000579_abnormal_nail_morphology	1.02862666
56	MP0002127_abnormal_cardiovascular_syste	0.99126920
57	MP0002234_abnormal_pharynx_morphology	0.98850843
58	MP0005670_abnormal_white_adipose	0.97796834
59	MP0001790_abnormal_immune_system	0.97537363
60	MP0005387_immune_system_phenotype	0.97537363
61	MP0000685_abnormal_immune_system	0.93889908
62	MP0002332_abnormal_exercise_endurance	0.91024684
63	MP0001529_abnormal_vocalization	0.90716337
64	MP0001756_abnormal_urination	0.89861848
65	MP0000383_abnormal_hair_follicle	0.87948240
66	MP0001299_abnormal_eye_distance/	0.87586505
67	MP0005266_abnormal_metabolism	0.86112627
68	MP0006276_abnormal_autonomic_nervous	0.86021160
69	MP0000751_myopathy	0.85271165
70	MP0005083_abnormal_biliary_tract	0.85199698
71	MP0000427_abnormal_hair_cycle	0.82925659
72	MP0002972_abnormal_cardiac_muscle	0.80335417
73	MP0005379_endocrine/exocrine_gland_phen	0.79734651
74	MP0000681_abnormal_thyroid_gland	0.77905455
75	MP0003195_calcinosis	0.77172103
76	MP0001800_abnormal_humoral_immune	0.77147997
77	MP0001968_abnormal_touch/_nociception	0.75537721
78	MP0002148_abnormal_hypersensitivity_rea	0.74771748
79	MP0002277_abnormal_respiratory_mucosa	0.74614137
80	MP0002876_abnormal_thyroid_physiology	0.74548718
81	MP0005646_abnormal_pituitary_gland	0.74492976
82	MP0008995_early_reproductive_senescence	0.74327319
83	MP0000465_gastrointestinal_hemorrhage	0.74196658
84	MP0005165_increased_susceptibility_to	0.72864406
85	MP0003718_maternal_effect	0.71782491
86	MP0003786_premature_aging	0.71631367
87	MP0004145_abnormal_muscle_electrophysio	0.71412385
88	MP0001346_abnormal_lacrimal_gland	0.70144947
89	MP0002166_altered_tumor_susceptibility	0.69430799
90	MP0003186_abnormal_redox_activity	0.68694734
91	MP0002163_abnormal_gland_morphology	0.68377553
92	MP0003763_abnormal_thymus_physiology	0.67534044
93	MP0010329_abnormal_lipoprotein_level	0.63061015
94	MP0001764_abnormal_homeostasis	0.61770205
95	MP0004782_abnormal_surfactant_physiolog	0.59831614
96	MP0002272_abnormal_nervous_system	0.59608741
97	MP0009764_decreased_sensitivity_to	0.58958139
98	MP0005410_abnormal_fertilization	0.58636334
99	MP0000343_altered_response_to	0.56753052
100	MP0001879_abnormal_lymphatic_vessel	0.56521555

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased circulating renin level (HP:0003351)	7.43529657
2	Abnormal drinking behavior (HP:0030082)	5.83814679
3	Polydipsia (HP:0001959)	5.83814679
4	Stenosis of the external auditory canal (HP:0000402)	4.76085958
5	Abnormality of renin-angiotensin system (HP:0000847)	4.30806106
6	Polyuria (HP:0000103)	3.89395555
7	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.85289036
8	Split foot (HP:0001839)	3.71048996
9	Tongue fasciculations (HP:0001308)	3.46228094
10	Abnormal urine output (HP:0012590)	3.17507506
11	Muscle fibrillation (HP:0010546)	2.96285071
12	Nephronophthisis (HP:0000090)	2.93497988
13	True hermaphroditism (HP:0010459)	2.92406579
14	Congenital, generalized hypertrichosis (HP:0004540)	2.92148440
15	Chronic otitis media (HP:0000389)	2.88326874
16	Delayed CNS myelination (HP:0002188)	2.80973909
17	Abnormality of the 2nd finger (HP:0004100)	2.68512054
18	Hematochezia (HP:0002573)	2.62411253
19	Abnormality of renal excretion (HP:0011036)	2.57962548
20	Inability to walk (HP:0002540)	2.48748608
21	Pancreatic cysts (HP:0001737)	2.37236830
22	Abnormality of midbrain morphology (HP:0002418)	2.35535962
23	Molar tooth sign on MRI (HP:0002419)	2.35535962
24	Neonatal onset (HP:0003623)	2.33509034
25	Renal cortical cysts (HP:0000803)	2.32172730
26	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31578294
27	Supernumerary bones of the axial skeleton (HP:0009144)	2.30095224
28	Pancreatic fibrosis (HP:0100732)	2.27924039
29	Absent/shortened dynein arms (HP:0200106)	2.26776135
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.26776135
31	Gonadal dysgenesis (HP:0000133)	2.24537518
32	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.24449219
33	Neonatal respiratory distress (HP:0002643)	2.24145266
34	Abnormality of the parietal bone (HP:0002696)	2.22537377
35	Stomatitis (HP:0010280)	2.20717719
36	Abnormality of the middle phalanges of the toes (HP:0010183)	2.18335897
37	Abnormal respiratory epithelium morphology (HP:0012253)	2.15944069
38	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15944069
39	Progressive inability to walk (HP:0002505)	2.15839763
40	Hypoproteinemia (HP:0003075)	2.13858306
41	Pigmentary retinal degeneration (HP:0001146)	2.13642705
42	Anophthalmia (HP:0000528)	2.12639540
43	Insulin-resistant diabetes mellitus (HP:0000831)	2.12374727
44	Abnormality of the renal medulla (HP:0100957)	2.11646028
45	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.11417906
46	Aplasia/hypoplasia of the uterus (HP:0008684)	2.07109091
47	Hyponatremia (HP:0002902)	2.05754019
48	Dyschromatopsia (HP:0007641)	2.05551558
49	Coronal craniosynostosis (HP:0004440)	2.05171300
50	Hypoplasia of the uterus (HP:0000013)	2.03253012
51	Aplasia of the phalanges of the hand (HP:0009802)	2.03153804
52	Aplasia involving bones of the extremities (HP:0009825)	2.03153804
53	Aplasia involving bones of the upper limbs (HP:0009823)	2.03153804
54	Oligodactyly (hands) (HP:0001180)	1.99512098
55	Abolished electroretinogram (ERG) (HP:0000550)	1.99276551
56	Increased hepatocellular lipid droplets (HP:0006565)	1.99220357
57	Acute necrotizing encephalopathy (HP:0006965)	1.98904283
58	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.98719732
59	Conical tooth (HP:0000698)	1.98568249
60	Carpal bone hypoplasia (HP:0001498)	1.97744042
61	Tubular atrophy (HP:0000092)	1.96940515
62	Broad alveolar ridges (HP:0000187)	1.95863228
63	Alacrima (HP:0000522)	1.94963758
64	Abnormality of the renal cortex (HP:0011035)	1.93651081
65	Partial duplication of the phalanx of hand (HP:0009999)	1.90350056
66	Hemoptysis (HP:0002105)	1.88247089
67	2-3 toe syndactyly (HP:0004691)	1.87499634
68	Areflexia of lower limbs (HP:0002522)	1.86767072
69	Abnormal ciliary motility (HP:0012262)	1.85394240
70	IgG deficiency (HP:0004315)	1.84254210
71	Medial flaring of the eyebrow (HP:0010747)	1.83983092
72	Mitochondrial inheritance (HP:0001427)	1.83529081
73	Oligodactyly (HP:0012165)	1.83105866
74	Hyperglycemia (HP:0003074)	1.82884586
75	Acute encephalopathy (HP:0006846)	1.82775546
76	Supernumerary ribs (HP:0005815)	1.81546480
77	Rhinitis (HP:0012384)	1.81415059
78	Abnormality of the labia minora (HP:0012880)	1.79117311
79	Congenital stationary night blindness (HP:0007642)	1.77894693
80	Vaginal atresia (HP:0000148)	1.77275964
81	Anteriorly placed anus (HP:0001545)	1.76935603
82	Abnormality of the prostate (HP:0008775)	1.76790468
83	Chronic sinusitis (HP:0011109)	1.73212168
84	Genital tract atresia (HP:0001827)	1.72157348
85	Aqueductal stenosis (HP:0002410)	1.71386072
86	Hyporeflexia of lower limbs (HP:0002600)	1.70278598
87	Choroideremia (HP:0001139)	1.70238146
88	Increased CSF lactate (HP:0002490)	1.70235175
89	Severe combined immunodeficiency (HP:0004430)	1.69461398
90	Hepatosplenomegaly (HP:0001433)	1.68891271
91	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.66210360
92	Elevated erythrocyte sedimentation rate (HP:0003565)	1.65114603
93	Limb hypertonia (HP:0002509)	1.64872538
94	Bilateral microphthalmos (HP:0007633)	1.64754377
95	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.63336868
96	Hypoplastic scapulae (HP:0000882)	1.63336868
97	Aplasia/Hypoplasia of the clavicles (HP:0006710)	1.63202601
98	Attenuation of retinal blood vessels (HP:0007843)	1.62977961
99	Myelomeningocele (HP:0002475)	1.62387563
100	Congenital hepatic fibrosis (HP:0002612)	1.61756619

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.46631161
2	BCR	3.55923738
3	MAP4K2	2.84879435
4	TGFBR2	2.67567382
5	NUAK1	2.67048875
6	TSSK6	2.57807216
7	FGFR2	2.49365229
8	BLK	2.39733946
9	TRIM28	2.38598574
10	MST4	2.28926088
11	EPHA4	2.25258665
12	TXK	2.20284941
13	TAOK3	2.12940920
14	EIF2AK3	2.06043977
15	WNK3	2.02895217
16	EPHB2	1.99420052
17	SIK3	1.93805013
18	TLK1	1.78860494
19	FRK	1.69316779
20	GRK1	1.64848608
21	OXSR1	1.48098181
22	TEC	1.43419335
23	EPHA3	1.42400209
24	CSNK1A1L	1.40590994
25	CSNK1G3	1.39659504
26	LIMK1	1.38676552
27	ADRBK2	1.36791543
28	CSNK1G2	1.36486390
29	EIF2AK2	1.35606722
30	STK38L	1.28739906
31	CSNK1G1	1.24638145
32	SRPK1	1.17579573
33	PLK4	1.14523293
34	PLK3	1.14048530
35	FES	1.11236991
36	GRK7	1.10561791
37	MAPK13	1.09443167
38	AKT3	1.05739840
39	GRK5	1.02394231
40	WNK4	1.00593101
41	PINK1	0.99924018
42	MAP3K4	0.99258439
43	MKNK1	0.98552929
44	NEK1	0.95440040
45	CASK	0.93994189
46	PLK2	0.92469940
47	PKN1	0.86157390
48	MOS	0.85219805
49	INSRR	0.84356531
50	KIT	0.79935799
51	MINK1	0.77997087
52	TYK2	0.77407121
53	PTK2B	0.77089179
54	VRK1	0.76908434
55	FGFR1	0.73704347
56	KDR	0.72103015
57	CSF1R	0.71056754
58	ERBB3	0.69679051
59	MAP3K5	0.68843931
60	JAK1	0.67856935
61	STK39	0.67525491
62	MKNK2	0.65471353
63	LATS1	0.62325122
64	CAMK2A	0.62287035
65	PHKG2	0.62108225
66	PHKG1	0.62108225
67	BMPR1B	0.61265965
68	NTRK2	0.59562084
69	VRK2	0.58711310
70	PRKCE	0.57023969
71	MAP2K6	0.55615493
72	CAMK4	0.55485052
73	UHMK1	0.55006354
74	EGFR	0.54374816
75	IGF1R	0.53102233
76	TNIK	0.52666360
77	ITK	0.51535275
78	STK10	0.51043718
79	MAP2K7	0.49762017
80	FGFR3	0.48642521
81	OBSCN	0.45462757
82	NEK9	0.45192797
83	TGFBR1	0.45094428
84	PRKG1	0.42696074
85	TAF1	0.40654684
86	HCK	0.39175306
87	PRKACA	0.39137889
88	WEE1	0.39037664
89	ADRBK1	0.37476717
90	MYLK	0.37286379
91	PAK3	0.36667477
92	SYK	0.36333413
93	MAPK15	0.35767073
94	PRKD3	0.34735824
95	CDK19	0.33771072
96	IKBKE	0.33404352
97	PASK	0.33238460
98	ROCK1	0.32188537
99	PNCK	0.31763811
100	ZAK	0.31155397

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.45889928
2	Proteasome_Homo sapiens_hsa03050	3.26364493
3	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	3.09316669
4	Propanoate metabolism_Homo sapiens_hsa00640	2.66921684
5	Asthma_Homo sapiens_hsa05310	2.45743130
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.35644185
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.22868405
8	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.14565650
9	Phototransduction_Homo sapiens_hsa04744	2.11442015
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.06316561
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98829902
12	Allograft rejection_Homo sapiens_hsa05330	1.98486371
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.94163881
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.89637010
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.86921281
16	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.83982578
17	Parkinsons disease_Homo sapiens_hsa05012	1.80825596
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.79236014
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.74416177
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.66891564
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.38839443
22	Purine metabolism_Homo sapiens_hsa00230	1.38562188
23	RNA degradation_Homo sapiens_hsa03018	1.37369613
24	Fatty acid elongation_Homo sapiens_hsa00062	1.28284155
25	Huntingtons disease_Homo sapiens_hsa05016	1.23300081
26	beta-Alanine metabolism_Homo sapiens_hsa00410	1.21078039
27	Sulfur metabolism_Homo sapiens_hsa00920	1.19624263
28	Antigen processing and presentation_Homo sapiens_hsa04612	1.18621595
29	Retinol metabolism_Homo sapiens_hsa00830	1.14881036
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.14659256
31	Fatty acid degradation_Homo sapiens_hsa00071	1.13669507
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.13574392
33	Rheumatoid arthritis_Homo sapiens_hsa05323	1.13185495
34	Non-homologous end-joining_Homo sapiens_hsa03450	1.12139398
35	Peroxisome_Homo sapiens_hsa04146	1.11953845
36	Spliceosome_Homo sapiens_hsa03040	1.11002810
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.10037985
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.08969197
39	Other glycan degradation_Homo sapiens_hsa00511	1.07732906
40	Viral myocarditis_Homo sapiens_hsa05416	1.07313788
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.06619496
42	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.05463979
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.03889691
44	Butanoate metabolism_Homo sapiens_hsa00650	1.02900757
45	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.01784960
46	Regulation of autophagy_Homo sapiens_hsa04140	1.01595061
47	Alzheimers disease_Homo sapiens_hsa05010	0.98880039
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.98738812
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.98127236
50	GABAergic synapse_Homo sapiens_hsa04727	0.96940572
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.94892107
52	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.94174719
53	Morphine addiction_Homo sapiens_hsa05032	0.91025259
54	Linoleic acid metabolism_Homo sapiens_hsa00591	0.89387253
55	RNA transport_Homo sapiens_hsa03013	0.85864361
56	Taste transduction_Homo sapiens_hsa04742	0.85383784
57	RNA polymerase_Homo sapiens_hsa03020	0.84519259
58	Caffeine metabolism_Homo sapiens_hsa00232	0.83390882
59	Pyruvate metabolism_Homo sapiens_hsa00620	0.75858414
60	Olfactory transduction_Homo sapiens_hsa04740	0.74864160
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.73137349
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.72483639
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.71691632
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.70905867
65	Nicotine addiction_Homo sapiens_hsa05033	0.70378946
66	Insulin secretion_Homo sapiens_hsa04911	0.69722428
67	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.69514619
68	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.68663149
69	Basal transcription factors_Homo sapiens_hsa03022	0.68569392
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67358683
71	Salivary secretion_Homo sapiens_hsa04970	0.66150034
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63814324
73	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.63701000
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63507446
75	Serotonergic synapse_Homo sapiens_hsa04726	0.62827300
76	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.62668272
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61718899
78	Renin secretion_Homo sapiens_hsa04924	0.59964117
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.58564535
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.57977179
81	Gastric acid secretion_Homo sapiens_hsa04971	0.57183863
82	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.56440632
83	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.55104070
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53776215
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.52038106
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.50331729
87	Homologous recombination_Homo sapiens_hsa03440	0.48715443
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.47644032
89	Circadian rhythm_Homo sapiens_hsa04710	0.47269569
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.47019661
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45525412
92	Fanconi anemia pathway_Homo sapiens_hsa03460	0.44059191
93	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.43138658
94	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.40789169
95	One carbon pool by folate_Homo sapiens_hsa00670	0.39696464
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39177078
97	Circadian entrainment_Homo sapiens_hsa04713	0.37594500
98	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.36207320
99	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.35809339
100	Glutathione metabolism_Homo sapiens_hsa00480	0.34874443

GDI2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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