GDPD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycerophosphodiester phosphodiesterase family of enzymes that catalyze the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. The encoded protein is localized to the cytoplasm and concentrates near the perinuclear region. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.38191597
2neuron cell-cell adhesion (GO:0007158)5.31627954
3vocalization behavior (GO:0071625)4.20172525
4presynaptic membrane assembly (GO:0097105)4.14934652
5neuron recognition (GO:0008038)4.09128465
6synaptic vesicle exocytosis (GO:0016079)4.08907171
7presynaptic membrane organization (GO:0097090)4.03717958
8central nervous system myelination (GO:0022010)4.01423871
9axon ensheathment in central nervous system (GO:0032291)4.01423871
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95811141
11protein polyglutamylation (GO:0018095)3.84342827
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.80561095
13protein localization to synapse (GO:0035418)3.78751253
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.77472431
15axonal fasciculation (GO:0007413)3.70526442
16pyrimidine nucleobase catabolic process (GO:0006208)3.69337937
17nonmotile primary cilium assembly (GO:0035058)3.67280917
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.49816751
19regulation of synaptic vesicle exocytosis (GO:2000300)3.44397545
20cell migration in hindbrain (GO:0021535)3.43335814
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.40809828
22postsynaptic membrane organization (GO:0001941)3.36126901
23regulation of glutamate receptor signaling pathway (GO:1900449)3.36039444
24protein neddylation (GO:0045116)3.35334618
25behavioral response to ethanol (GO:0048149)3.35239675
26regulation of cilium movement (GO:0003352)3.33271346
27chaperone-mediated protein transport (GO:0072321)3.29636966
28positive regulation of synapse assembly (GO:0051965)3.28679211
29response to pheromone (GO:0019236)3.28271663
30cerebral cortex radially oriented cell migration (GO:0021799)3.27035587
31glutamate receptor signaling pathway (GO:0007215)3.25558636
32synaptic transmission, glutamatergic (GO:0035249)3.25367209
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25038078
34retinal ganglion cell axon guidance (GO:0031290)3.21606014
35epithelial cilium movement (GO:0003351)3.21095239
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15821080
37neuron-neuron synaptic transmission (GO:0007270)3.15169576
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12878831
39long-chain fatty acid biosynthetic process (GO:0042759)3.10975754
40apical protein localization (GO:0045176)3.09633581
41glutamate secretion (GO:0014047)3.09046937
42axoneme assembly (GO:0035082)3.07043976
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.06183599
44dendritic spine morphogenesis (GO:0060997)3.04572861
45regulation of synaptic vesicle transport (GO:1902803)3.04476873
46nucleobase catabolic process (GO:0046113)3.04390279
47neuronal action potential propagation (GO:0019227)3.02876157
48layer formation in cerebral cortex (GO:0021819)3.02620143
49ubiquinone biosynthetic process (GO:0006744)3.02515869
50negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.01947983
51ubiquinone metabolic process (GO:0006743)3.01946463
52synaptic transmission, cholinergic (GO:0007271)3.00162056
53limb bud formation (GO:0060174)2.99197873
54negative regulation of neurotransmitter transport (GO:0051589)2.98569493
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.97791653
56neurotransmitter-gated ion channel clustering (GO:0072578)2.97680314
57dendrite morphogenesis (GO:0048813)2.97580636
58L-fucose catabolic process (GO:0042355)2.96932834
59fucose catabolic process (GO:0019317)2.96932834
60L-fucose metabolic process (GO:0042354)2.96932834
61cornea development in camera-type eye (GO:0061303)2.94738076
62dendrite development (GO:0016358)2.94224513
63gamma-aminobutyric acid transport (GO:0015812)2.93603227
64establishment of mitochondrion localization (GO:0051654)2.93130499
65negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93082331
66glycerophospholipid catabolic process (GO:0046475)2.92856173
67transmission of nerve impulse (GO:0019226)2.92159199
68negative regulation of microtubule polymerization (GO:0031115)2.91830530
69mitochondrial respiratory chain complex I assembly (GO:0032981)2.91583860
70NADH dehydrogenase complex assembly (GO:0010257)2.91583860
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91583860
72central nervous system projection neuron axonogenesis (GO:0021952)2.91007981
73startle response (GO:0001964)2.90014645
74synapse assembly (GO:0007416)2.87931727
75head development (GO:0060322)2.87656738
76protein complex biogenesis (GO:0070271)2.86947888
77regulation of action potential (GO:0098900)2.85718657
78energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.84079789
79ATP hydrolysis coupled proton transport (GO:0015991)2.84079789
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84049309
81synaptic vesicle maturation (GO:0016188)2.83401890
82somite development (GO:0061053)2.82796071
83cerebellar granule cell differentiation (GO:0021707)2.81605430
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80665792
85positive regulation of mitochondrial fission (GO:0090141)2.79337638
86synaptic vesicle endocytosis (GO:0048488)2.78359444
87negative regulation of response to food (GO:0032096)2.76910007
88negative regulation of appetite (GO:0032099)2.76910007
89neuronal action potential (GO:0019228)2.75201220
90exploration behavior (GO:0035640)2.75107920
91membrane hyperpolarization (GO:0060081)2.75068001
92negative regulation of telomere maintenance (GO:0032205)2.75032792
93cilium movement (GO:0003341)2.74413968
94neurotransmitter secretion (GO:0007269)2.73896621
95innervation (GO:0060384)2.73601302
96locomotory exploration behavior (GO:0035641)2.73306348
97regulation of microtubule-based movement (GO:0060632)2.73091321
98water-soluble vitamin biosynthetic process (GO:0042364)2.72790724
99regulation of synapse assembly (GO:0051963)2.72503733
100spinal cord development (GO:0021510)2.71002473
101centriole replication (GO:0007099)2.69144270
102regulation of female gonad development (GO:2000194)2.69054475
103auditory behavior (GO:0031223)2.67001549
104righting reflex (GO:0060013)2.66500644
105membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65935991
106establishment of protein localization to mitochondrial membrane (GO:0090151)2.64411102
107kynurenine metabolic process (GO:0070189)2.64385397
108transferrin transport (GO:0033572)2.63664530
109detection of light stimulus involved in sensory perception (GO:0050962)2.63385389
110detection of light stimulus involved in visual perception (GO:0050908)2.63385389
111cilium morphogenesis (GO:0060271)2.62989234
112parturition (GO:0007567)2.62600438
113cerebellar Purkinje cell differentiation (GO:0021702)2.62282494
114intraciliary transport (GO:0042073)2.61571167
115neural tube formation (GO:0001841)2.59402634
116neurofilament cytoskeleton organization (GO:0060052)2.58895759
117long-term synaptic potentiation (GO:0060291)2.58498008
118adult walking behavior (GO:0007628)2.58180861
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58111868
120asymmetric protein localization (GO:0008105)2.57821574
121regulation of neuronal synaptic plasticity (GO:0048168)2.57485484
122protein localization to cilium (GO:0061512)2.56954658
123indolalkylamine metabolic process (GO:0006586)2.56540529
124establishment of synaptic vesicle localization (GO:0097480)2.53405590
125synaptic vesicle transport (GO:0048489)2.53405590
126hippocampus development (GO:0021766)2.53267097
127response to auditory stimulus (GO:0010996)2.52078350
128mitochondrial respiratory chain complex assembly (GO:0033108)2.51978287
129synapse organization (GO:0050808)2.51805203
130regulation of respiratory system process (GO:0044065)2.51183716
131regulation of synaptic transmission, glutamatergic (GO:0051966)2.50797300
132neurotransmitter transport (GO:0006836)2.50456377
133piRNA metabolic process (GO:0034587)2.50353962
134negative regulation of axonogenesis (GO:0050771)2.49541090
135olfactory bulb development (GO:0021772)2.49451638
136eye photoreceptor cell differentiation (GO:0001754)2.48846017
137photoreceptor cell differentiation (GO:0046530)2.48846017
138mechanosensory behavior (GO:0007638)2.48758599
139negative regulation of neurotransmitter secretion (GO:0046929)2.48665807
140regulation of synapse structural plasticity (GO:0051823)2.47780667
141mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.47648021
142cochlea development (GO:0090102)2.47462242
143cilium organization (GO:0044782)2.46719974
144regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46212210
145ferric iron transport (GO:0015682)2.45644490
146trivalent inorganic cation transport (GO:0072512)2.45644490
147negative regulation of axon extension (GO:0030517)2.45387655
148positive regulation of gastrulation (GO:2000543)2.44526806
149microtubule bundle formation (GO:0001578)2.44405024
150tryptophan catabolic process (GO:0006569)2.44335386
151indole-containing compound catabolic process (GO:0042436)2.44335386
152indolalkylamine catabolic process (GO:0046218)2.44335386
153substrate-independent telencephalic tangential migration (GO:0021826)2.44160735
154substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.44160735
155adult behavior (GO:0030534)2.43964903
156regulation of dendritic spine morphogenesis (GO:0061001)2.43920104
157cilium assembly (GO:0042384)2.43795248
158establishment of vesicle localization (GO:0051650)2.43352467
159positive regulation of action potential (GO:0045760)2.43088304
160mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42994410
161adaptation of signaling pathway (GO:0023058)2.40994853
162ATP synthesis coupled proton transport (GO:0015986)2.40213415
163energy coupled proton transport, down electrochemical gradient (GO:0015985)2.40213415
164membrane depolarization during action potential (GO:0086010)2.39931550
165cellular ketone body metabolic process (GO:0046950)2.39146291
166limb development (GO:0060173)2.37585218
167appendage development (GO:0048736)2.37585218
168photoreceptor cell development (GO:0042461)2.37525730
169protein-cofactor linkage (GO:0018065)2.37482000
170preassembly of GPI anchor in ER membrane (GO:0016254)2.37184746
171C4-dicarboxylate transport (GO:0015740)2.36394382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.70414846
2GBX2_23144817_ChIP-Seq_PC3_Human3.64592240
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54715606
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54179553
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47159571
6TAF15_26573619_Chip-Seq_HEK293_Human2.36907719
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.34565413
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25281445
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19713749
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19129597
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19129597
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16734724
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13243278
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12201471
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12184049
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11350671
17REST_21632747_ChIP-Seq_MESCs_Mouse2.10573537
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10097233
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08418822
20VDR_22108803_ChIP-Seq_LS180_Human2.05433655
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.04833204
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02182360
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.01396496
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00527614
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99310925
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97962424
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.97741626
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94322407
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.94187348
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93796392
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88747949
32IGF1R_20145208_ChIP-Seq_DFB_Human1.87542151
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84663686
34RNF2_27304074_Chip-Seq_NSC_Mouse1.84321481
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83325198
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79108130
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69953237
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69499622
39P300_19829295_ChIP-Seq_ESCs_Human1.68868352
40* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66038261
41SMAD4_21799915_ChIP-Seq_A2780_Human1.61504357
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.60684049
43FUS_26573619_Chip-Seq_HEK293_Human1.59956675
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.59254788
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55312263
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54568562
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54415869
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53832116
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52901811
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52855732
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.51841090
52IRF1_19129219_ChIP-ChIP_H3396_Human1.51006381
53TP53_22573176_ChIP-Seq_HFKS_Human1.48847276
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47638407
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.47329766
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47130974
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46200782
58AR_21572438_ChIP-Seq_LNCaP_Human1.45286062
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.44403603
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43595230
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.42707778
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42424666
63* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40495171
64* CBP_20019798_ChIP-Seq_JUKART_Human1.40495171
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38446099
66* ER_23166858_ChIP-Seq_MCF-7_Human1.37206426
67ZNF274_21170338_ChIP-Seq_K562_Hela1.36535309
68DROSHA_22980978_ChIP-Seq_HELA_Human1.34909319
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31577557
70* RARB_27405468_Chip-Seq_BRAIN_Mouse1.29917311
71AR_25329375_ChIP-Seq_VCAP_Human1.29393563
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29303999
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28467493
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25437823
75STAT3_23295773_ChIP-Seq_U87_Human1.24797965
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.21981906
77* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21785294
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21647988
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20895578
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20895578
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.20794737
82MYC_18940864_ChIP-ChIP_HL60_Human1.20293183
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20118640
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.19742334
85* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19033063
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16962012
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16096669
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15997082
89TCF4_22108803_ChIP-Seq_LS180_Human1.14811270
90RUNX2_22187159_ChIP-Seq_PCA_Human1.12780699
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.12712731
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12501895
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.11341513
94AHR_22903824_ChIP-Seq_MCF-7_Human1.11079709
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09864567
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09752837
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08974534
98NANOG_19829295_ChIP-Seq_ESCs_Human1.08602884
99SOX2_19829295_ChIP-Seq_ESCs_Human1.08602884
100* TCF4_23295773_ChIP-Seq_U87_Human1.08441098
101* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07752474
102* NCOR_22424771_ChIP-Seq_293T_Human1.07127178
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.06806910
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06795422
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06736875
106KDM2B_26808549_Chip-Seq_REH_Human1.04382496
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.03913557
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03348624
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03039385
110EST1_17652178_ChIP-ChIP_JURKAT_Human1.02778002
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02487881
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.02286231
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.01656378
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01259794
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00713831
116JUN_21703547_ChIP-Seq_K562_Human0.99232604
117EWS_26573619_Chip-Seq_HEK293_Human0.98549284
118E2F1_18555785_Chip-Seq_ESCs_Mouse0.98014736
119P53_22387025_ChIP-Seq_ESCs_Mouse0.97837520
120* GATA3_21878914_ChIP-Seq_MCF-7_Human0.97375440
121* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97250311
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97102459
123* RING1B_27294783_Chip-Seq_NPCs_Mouse0.95988460
124SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95635181
125FOXA1_25329375_ChIP-Seq_VCAP_Human0.95459930
126FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95459930
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95053569
128BCAT_22108803_ChIP-Seq_LS180_Human0.94728577
129TP53_18474530_ChIP-ChIP_U2OS_Human0.94663573
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.94623903
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92452830
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92334970
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.91109960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.89792445
2MP0004859_abnormal_synaptic_plasticity4.01462186
3MP0004270_analgesia3.30905426
4MP0003635_abnormal_synaptic_transmissio2.89242852
5MP0005423_abnormal_somatic_nervous2.82666240
6MP0001529_abnormal_vocalization2.65914670
7MP0000778_abnormal_nervous_system2.64104328
8MP0006276_abnormal_autonomic_nervous2.61273103
9MP0002734_abnormal_mechanical_nocicepti2.52594913
10MP0002063_abnormal_learning/memory/cond2.51710221
11MP0006292_abnormal_olfactory_placode2.47736378
12MP0002735_abnormal_chemical_nociception2.45933909
13MP0009745_abnormal_behavioral_response2.42019141
14MP0001968_abnormal_touch/_nociception2.41686474
15MP0002064_seizures2.34807121
16MP0002572_abnormal_emotion/affect_behav2.32790011
17MP0009046_muscle_twitch2.32389422
18MP0002736_abnormal_nociception_after2.23017410
19MP0002272_abnormal_nervous_system2.17116985
20MP0001486_abnormal_startle_reflex2.14389984
21MP0001905_abnormal_dopamine_level2.02814212
22MP0001984_abnormal_olfaction1.95442327
23MP0002184_abnormal_innervation1.95211365
24MP0009780_abnormal_chondrocyte_physiolo1.94977316
25MP0005645_abnormal_hypothalamus_physiol1.89120722
26MP0004133_heterotaxia1.85360577
27MP0001440_abnormal_grooming_behavior1.84770072
28MP0002733_abnormal_thermal_nociception1.83446016
29MP0002067_abnormal_sensory_capabilities1.79665654
30MP0002102_abnormal_ear_morphology1.75844154
31MP0001970_abnormal_pain_threshold1.74742022
32MP0003787_abnormal_imprinting1.74629481
33MP0004147_increased_porphyrin_level1.72019075
34MP0005386_behavior/neurological_phenoty1.69561541
35MP0004924_abnormal_behavior1.69561541
36MP0010386_abnormal_urinary_bladder1.69102998
37MP0002557_abnormal_social/conspecific_i1.64655167
38MP0001188_hyperpigmentation1.60045656
39MP0005646_abnormal_pituitary_gland1.59345428
40MP0003329_amyloid_beta_deposits1.57128765
41MP0004742_abnormal_vestibular_system1.57108306
42MP0001485_abnormal_pinna_reflex1.54175649
43MP0002837_dystrophic_cardiac_calcinosis1.54041013
44MP0000955_abnormal_spinal_cord1.52680844
45MP0002882_abnormal_neuron_morphology1.52403936
46MP0001501_abnormal_sleep_pattern1.50239548
47MP0000569_abnormal_digit_pigmentation1.49073209
48MP0006072_abnormal_retinal_apoptosis1.47971533
49MP0004885_abnormal_endolymph1.43996929
50MP0003011_delayed_dark_adaptation1.40193051
51MP0004043_abnormal_pH_regulation1.38761778
52MP0004811_abnormal_neuron_physiology1.36858567
53MP0000566_synostosis1.29368248
54MP0000631_abnormal_neuroendocrine_gland1.29252361
55MP0001963_abnormal_hearing_physiology1.28868638
56MP0002822_catalepsy1.28087096
57MP0008872_abnormal_physiological_respon1.27789776
58MP0005551_abnormal_eye_electrophysiolog1.25828924
59MP0002234_abnormal_pharynx_morphology1.25431545
60MP0005410_abnormal_fertilization1.24609127
61MP0002752_abnormal_somatic_nervous1.22160814
62MP0002066_abnormal_motor_capabilities/c1.22057891
63MP0003122_maternal_imprinting1.21922938
64MP0000026_abnormal_inner_ear1.20539290
65MP0003890_abnormal_embryonic-extraembry1.20106856
66MP0002152_abnormal_brain_morphology1.18426300
67MP0002638_abnormal_pupillary_reflex1.16886581
68MP0004142_abnormal_muscle_tone1.15859726
69MP0003879_abnormal_hair_cell1.14980924
70MP0005171_absent_coat_pigmentation1.14669427
71MP0002938_white_spotting1.14266747
72MP0002229_neurodegeneration1.13441398
73MP0005499_abnormal_olfactory_system1.12777384
74MP0005394_taste/olfaction_phenotype1.12777384
75MP0002160_abnormal_reproductive_system1.12117901
76MP0008569_lethality_at_weaning1.11136756
77MP0008789_abnormal_olfactory_epithelium1.10827558
78MP0000427_abnormal_hair_cycle1.10363976
79MP0001502_abnormal_circadian_rhythm1.09986991
80MP0003634_abnormal_glial_cell1.09121597
81MP0008995_early_reproductive_senescence1.08585768
82MP0003136_yellow_coat_color1.07194845
83MP0000920_abnormal_myelination1.06369969
84MP0008875_abnormal_xenobiotic_pharmacok1.04385730
85MP0002653_abnormal_ependyma_morphology1.03911735
86MP0002751_abnormal_autonomic_nervous1.02690309
87MP0008877_abnormal_DNA_methylation1.02608701
88MP0005084_abnormal_gallbladder_morpholo1.02291773
89MP0004858_abnormal_nervous_system1.02244759
90MP0000372_irregular_coat_pigmentation1.01683817
91MP0003123_paternal_imprinting1.00829576
92MP0002876_abnormal_thyroid_physiology1.00708900
93MP0003646_muscle_fatigue0.99623366
94MP0003195_calcinosis0.99321493
95MP0000462_abnormal_digestive_system0.96692535
96MP0000537_abnormal_urethra_morphology0.95575100
97MP0003718_maternal_effect0.93876986
98MP0005253_abnormal_eye_physiology0.93428002
99MP0003861_abnormal_nervous_system0.93020731
100MP0000049_abnormal_middle_ear0.92900780
101MP0003938_abnormal_ear_development0.91654188
102MP0002163_abnormal_gland_morphology0.90616592
103MP0005389_reproductive_system_phenotype0.89926514
104MP0003121_genomic_imprinting0.89479839
105MP0005187_abnormal_penis_morphology0.88938117
106MP0001293_anophthalmia0.87419206
107MP0003183_abnormal_peptide_metabolism0.84885071
108MP0001299_abnormal_eye_distance/0.84275942
109MP0000647_abnormal_sebaceous_gland0.84039670
110MP0005379_endocrine/exocrine_gland_phen0.83720524
111MP0003632_abnormal_nervous_system0.83079778
112MP0001919_abnormal_reproductive_system0.82608432
113MP0005167_abnormal_blood-brain_barrier0.81979314
114MP0002095_abnormal_skin_pigmentation0.80918771
115MP0003698_abnormal_male_reproductive0.80598949
116MP0001664_abnormal_digestion0.78567263
117MP0000538_abnormal_urinary_bladder0.77790062
118MP0005195_abnormal_posterior_eye0.75544815
119MP0002069_abnormal_eating/drinking_beha0.75526538
120MP0003631_nervous_system_phenotype0.74730420
121MP0001986_abnormal_taste_sensitivity0.72632000
122MP0002909_abnormal_adrenal_gland0.71518989
123MP0003950_abnormal_plasma_membrane0.71053342
124MP0008260_abnormal_autophagy0.69725632
125MP0000015_abnormal_ear_pigmentation0.66237141
126MP0005451_abnormal_body_composition0.65913761
127MP0001943_abnormal_respiration0.65694787
128MP0000751_myopathy0.65489097
129MP0004145_abnormal_muscle_electrophysio0.64935263
130MP0005409_darkened_coat_color0.63447230

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.45454212
2Myokymia (HP:0002411)4.23273640
3Pancreatic cysts (HP:0001737)4.06380373
4Pancreatic fibrosis (HP:0100732)3.92083221
5Atonic seizures (HP:0010819)3.69173588
6Epileptic encephalopathy (HP:0200134)3.47253614
7True hermaphroditism (HP:0010459)3.45798279
8Gait imbalance (HP:0002141)3.42872605
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.32418186
10Congenital stationary night blindness (HP:0007642)3.25500191
11Medial flaring of the eyebrow (HP:0010747)3.18886931
12Focal seizures (HP:0007359)3.16039147
13Neurofibrillary tangles (HP:0002185)3.06485711
14Abnormal hair whorl (HP:0010721)3.05473276
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.03772205
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.03772205
17Febrile seizures (HP:0002373)3.03748745
18Hyperventilation (HP:0002883)2.99832678
19Absent/shortened dynein arms (HP:0200106)2.98580551
20Dynein arm defect of respiratory motile cilia (HP:0012255)2.98580551
21Progressive cerebellar ataxia (HP:0002073)2.97734906
22Congenital primary aphakia (HP:0007707)2.96046756
23Limb dystonia (HP:0002451)2.94795792
24Type II lissencephaly (HP:0007260)2.90813486
25Abnormality of the corticospinal tract (HP:0002492)2.87954238
26Vaginal atresia (HP:0000148)2.85664341
27Genital tract atresia (HP:0001827)2.83910264
28Pheochromocytoma (HP:0002666)2.83623643
29Abnormality of the renal medulla (HP:0100957)2.83076619
30Bile duct proliferation (HP:0001408)2.77140738
31Abnormal biliary tract physiology (HP:0012439)2.77140738
32Nephrogenic diabetes insipidus (HP:0009806)2.75133838
33Polyphagia (HP:0002591)2.71610035
34Supranuclear gaze palsy (HP:0000605)2.70400519
35Abnormal respiratory motile cilium physiology (HP:0012261)2.68495093
36Broad-based gait (HP:0002136)2.66758123
37Abnormality of the renal cortex (HP:0011035)2.59028507
38Absence seizures (HP:0002121)2.56668079
39Neuroendocrine neoplasm (HP:0100634)2.54492996
40Cystic liver disease (HP:0006706)2.54419882
41Cerebral inclusion bodies (HP:0100314)2.53952875
42Progressive inability to walk (HP:0002505)2.52212536
43Akinesia (HP:0002304)2.49035457
44Abolished electroretinogram (ERG) (HP:0000550)2.46818164
45Specific learning disability (HP:0001328)2.41118415
46Fetal akinesia sequence (HP:0001989)2.40520033
47Thickened helices (HP:0000391)2.40053403
48Excessive salivation (HP:0003781)2.40017897
49Drooling (HP:0002307)2.40017897
50Pachygyria (HP:0001302)2.36886898
51Abnormal ciliary motility (HP:0012262)2.36158770
523-Methylglutaconic aciduria (HP:0003535)2.35563400
53Dialeptic seizures (HP:0011146)2.34700729
54Generalized tonic-clonic seizures (HP:0002069)2.34547992
55Termporal pattern (HP:0011008)2.33387576
56Insidious onset (HP:0003587)2.33387576
57Mitochondrial inheritance (HP:0001427)2.31474436
58Acute necrotizing encephalopathy (HP:0006965)2.30795320
59Sclerocornea (HP:0000647)2.30529942
60Pendular nystagmus (HP:0012043)2.28942232
61Ankle clonus (HP:0011448)2.27701839
62Acute encephalopathy (HP:0006846)2.27064742
63Chronic hepatic failure (HP:0100626)2.24312736
64Poor coordination (HP:0002370)2.23538966
65Agitation (HP:0000713)2.21595625
66Postaxial foot polydactyly (HP:0001830)2.20453149
67Abnormal eating behavior (HP:0100738)2.19537013
68Amblyopia (HP:0000646)2.18317698
69Abnormality of the labia minora (HP:0012880)2.18253332
70Increased CSF lactate (HP:0002490)2.18084773
71Visual hallucinations (HP:0002367)2.16098517
72Intestinal atresia (HP:0011100)2.14997587
73Aplasia/Hypoplasia of the lens (HP:0008063)2.12056500
74Methylmalonic acidemia (HP:0002912)2.11874615
75Sensory axonal neuropathy (HP:0003390)2.11461824
76Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09060428
77Hypoplasia of the brainstem (HP:0002365)2.09060428
78Abnormal rod and cone electroretinograms (HP:0008323)2.08236394
79Spastic gait (HP:0002064)2.08093414
80Anencephaly (HP:0002323)2.06558684
81Dysmetria (HP:0001310)2.06414945
82Hyperglycinemia (HP:0002154)2.05590550
83Abnormal respiratory epithelium morphology (HP:0012253)2.05348056
84Abnormal respiratory motile cilium morphology (HP:0005938)2.05348056
85Postaxial hand polydactyly (HP:0001162)2.04307139
86Progressive macrocephaly (HP:0004481)2.02837061
87Hepatocellular necrosis (HP:0001404)2.02660663
88Occipital encephalocele (HP:0002085)2.02585477
89Mutism (HP:0002300)2.02074189
90Renal cortical cysts (HP:0000803)2.01361564
91Action tremor (HP:0002345)2.00647709
92Optic nerve hypoplasia (HP:0000609)2.00276644
93Epileptiform EEG discharges (HP:0011182)2.00121532
94Infertility (HP:0000789)2.00016198
95Increased serum pyruvate (HP:0003542)1.99564942
96Abnormality of glycolysis (HP:0004366)1.99564942
97Aplasia involving bones of the extremities (HP:0009825)1.98887804
98Aplasia involving bones of the upper limbs (HP:0009823)1.98887804
99Aplasia of the phalanges of the hand (HP:0009802)1.98887804
100Hypomagnesemia (HP:0002917)1.98669413
101Abnormality of salivation (HP:0100755)1.98092074
102Retinal dysplasia (HP:0007973)1.97936504
103Abnormal mitochondria in muscle tissue (HP:0008316)1.97560314
104Esotropia (HP:0000565)1.96762511
105Methylmalonic aciduria (HP:0012120)1.95882167
106Absent speech (HP:0001344)1.94728479
107Narrow forehead (HP:0000341)1.92848809
108Decreased central vision (HP:0007663)1.92094335
109Abnormality of alanine metabolism (HP:0010916)1.91938478
110Hyperalaninemia (HP:0003348)1.91938478
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91938478
112Congenital hepatic fibrosis (HP:0002612)1.91884164
113EEG with generalized epileptiform discharges (HP:0011198)1.91833756
114Oligodactyly (hands) (HP:0001180)1.90855382
115Cerebellar dysplasia (HP:0007033)1.90466915
116Thyroid-stimulating hormone excess (HP:0002925)1.90228855
117Lissencephaly (HP:0001339)1.89738053
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.89612540
119Failure to thrive in infancy (HP:0001531)1.89478638
120Abnormal drinking behavior (HP:0030082)1.89124400
121Polydipsia (HP:0001959)1.89124400
122Lipid accumulation in hepatocytes (HP:0006561)1.86160707
123Polyuria (HP:0000103)1.85764976
124Hepatic necrosis (HP:0002605)1.85602940
125Megalencephaly (HP:0001355)1.85263600
126Labial hypoplasia (HP:0000066)1.84321623
127Hypsarrhythmia (HP:0002521)1.84261277
128Hypothermia (HP:0002045)1.83920076
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83459478
130Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82745944
131Male pseudohermaphroditism (HP:0000037)1.82611459
132Anophthalmia (HP:0000528)1.82457576
133Attenuation of retinal blood vessels (HP:0007843)1.82193220
134Retinitis pigmentosa (HP:0000510)1.81017851
135Hemiparesis (HP:0001269)1.80928446
136Aplasia/Hypoplasia of the spleen (HP:0010451)1.79359251
137Preaxial hand polydactyly (HP:0001177)1.78655189
138Nephronophthisis (HP:0000090)1.78434367
139Tachypnea (HP:0002789)1.78163415
140Inability to walk (HP:0002540)1.77471581
141Growth hormone deficiency (HP:0000824)1.77278111
142Lower limb muscle weakness (HP:0007340)1.77021672
143Gaze-evoked nystagmus (HP:0000640)1.76865013
144Abnormality of midbrain morphology (HP:0002418)1.75661001
145Molar tooth sign on MRI (HP:0002419)1.75661001
146Rhinitis (HP:0012384)1.75648072
147Hypoplastic female external genitalia (HP:0012815)1.75595110
148Increased hepatocellular lipid droplets (HP:0006565)1.75460554
149Bony spicule pigmentary retinopathy (HP:0007737)1.74834122
150Optic disc pallor (HP:0000543)1.74572380
151Anxiety (HP:0000739)1.73229105
152Tubular atrophy (HP:0000092)1.73145840
153Intellectual disability, moderate (HP:0002342)1.72905796
154Choroideremia (HP:0001139)1.71679222
155Poor suck (HP:0002033)1.71652208
156Truncal ataxia (HP:0002078)1.69505934
157Synostosis involving the elbow (HP:0003938)1.68476548
158Humeroradial synostosis (HP:0003041)1.68476548
159Peripheral hypomyelination (HP:0007182)1.68438561
160Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67878084
161Leukodystrophy (HP:0002415)1.67326872
162Exotropia (HP:0000577)1.67164946
163Alacrima (HP:0000522)1.65096437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.09817662
2CASK3.95314306
3FRK3.21273493
4MAP3K42.57538869
5NTRK32.57051956
6EPHA42.48564802
7PINK12.39071831
8MAP2K72.38460329
9MAP4K22.33124550
10BMPR22.31730298
11MAPK132.27836535
12MAP3K92.26858414
13STK392.20586783
14GRK12.18250736
15DYRK22.13070803
16BCR2.02452919
17OXSR11.96139512
18NTRK21.95599345
19ZAK1.92179470
20PLK21.78107432
21BMPR1B1.73237383
22MINK11.70049077
23MAP3K121.67072255
24NUAK11.66891179
25TRIM281.56198978
26TNIK1.55047472
27CAMKK21.53273503
28SGK2231.46357607
29SGK4941.46357607
30PNCK1.44235869
31KSR11.43465220
32ARAF1.41832844
33CDK191.38986963
34UHMK11.34521871
35CSNK1G21.33793520
36PAK61.33474890
37PRPF4B1.31698273
38MOS1.31380646
39CSNK1G31.29490784
40BRAF1.27020436
41AKT31.26490171
42TLK11.21598005
43CAMK2B1.18852854
44LIMK11.18719210
45CDK51.18426701
46CAMK2A1.15328201
47BCKDK1.12022043
48ERBB41.11464958
49PHKG21.09540354
50PHKG11.09540354
51ERBB31.09177284
52DAPK21.08503202
53INSRR1.07557902
54PKN11.06568799
55NTRK11.03507173
56CSNK1A1L1.02769750
57NME11.00762730
58MAP2K41.00668263
59CSNK1G10.99406187
60MAP3K60.95426605
61MST40.93262938
62ROCK20.91882200
63KSR20.91637808
64TYRO30.89390101
65SGK20.88630399
66GRK50.88487249
67MKNK20.88407878
68DYRK1A0.86207631
69CDK180.85602717
70CDK140.83891735
71TXK0.83745814
72PRKD30.82741341
73PAK30.81987468
74CAMKK10.81214608
75DYRK30.81060890
76MUSK0.79087507
77CDK150.78972574
78PRKCE0.78072219
79PRKCG0.77446681
80CAMK2D0.75110129
81YES10.74947972
82CAMK10.74360589
83EPHB20.71090733
84WNK40.70971032
85ACVR1B0.70139779
86WNK30.67114763
87SIK20.65842781
88CDK11A0.65520436
89RPS6KA50.65463430
90FGR0.65384891
91CDK80.63474970
92RIPK40.62963582
93GRK70.61522019
94PLK40.61381656
95CAMK2G0.57009280
96ADRBK10.56943969
97LMTK20.56837857
98PIK3CA0.56695784
99VRK10.56648764
100NEK60.56097639
101STK160.55309401
102FGFR20.54943994
103PTK2B0.54220632
104CSNK1A10.52532607
105TIE10.51947116
106CAMK1G0.51358567
107CAMK40.49751794
108SGK10.49442133
109ROCK10.48767010
110MKNK10.47822585
111MAPKAPK50.47575806
112PRKCQ0.47033880
113NEK20.45215405
114PRKCZ0.44421013
115RPS6KA40.44172473
116WNK10.43548878
117PRKG10.43499209
118MARK20.43126745
119SIK30.42535651
120CSNK1D0.42442260
121DAPK10.42081280
122CAMK1D0.41685111
123LATS20.40705916
124RPS6KA20.37759095
125STK110.37559085
126TAOK30.37315335
127CDK30.36860463
128CSNK1E0.36729832
129CCNB10.36089676
130FER0.35653798
131MAP3K20.35577680
132PRKAA10.35544661
133PRKACA0.35228628
134ADRBK20.34878763
135STK38L0.33398362
136PRKACB0.33102481
137PRKCA0.33094950
138PLK30.32930739
139ERBB20.32257434
140TEC0.32033250
141MAP2K60.30154522

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.47462370
2Synaptic vesicle cycle_Homo sapiens_hsa047213.05948750
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.94661559
4Collecting duct acid secretion_Homo sapiens_hsa049662.79349410
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45360099
6Oxidative phosphorylation_Homo sapiens_hsa001902.26855167
7GABAergic synapse_Homo sapiens_hsa047272.25757739
8Glutamatergic synapse_Homo sapiens_hsa047242.16253425
9Olfactory transduction_Homo sapiens_hsa047402.13425367
10Vibrio cholerae infection_Homo sapiens_hsa051102.09758456
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04437411
12Nitrogen metabolism_Homo sapiens_hsa009102.04135239
13Morphine addiction_Homo sapiens_hsa050322.02996851
14Serotonergic synapse_Homo sapiens_hsa047262.02167326
15Circadian entrainment_Homo sapiens_hsa047131.98956714
16Dopaminergic synapse_Homo sapiens_hsa047281.96283667
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95956162
18Axon guidance_Homo sapiens_hsa043601.86990877
19Amphetamine addiction_Homo sapiens_hsa050311.79589846
20Taste transduction_Homo sapiens_hsa047421.76087869
21Long-term potentiation_Homo sapiens_hsa047201.67663691
22Long-term depression_Homo sapiens_hsa047301.65967280
23Alzheimers disease_Homo sapiens_hsa050101.60007034
24Parkinsons disease_Homo sapiens_hsa050121.59470239
25Cocaine addiction_Homo sapiens_hsa050301.58189545
26Cholinergic synapse_Homo sapiens_hsa047251.56440878
27Phototransduction_Homo sapiens_hsa047441.46714898
28Propanoate metabolism_Homo sapiens_hsa006401.43252357
29Basal transcription factors_Homo sapiens_hsa030221.43211969
30Salivary secretion_Homo sapiens_hsa049701.43017821
31Insulin secretion_Homo sapiens_hsa049111.42076639
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39050282
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37391951
34Ether lipid metabolism_Homo sapiens_hsa005651.36462209
35Cardiac muscle contraction_Homo sapiens_hsa042601.30659006
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30198036
37Huntingtons disease_Homo sapiens_hsa050161.30034825
38Caffeine metabolism_Homo sapiens_hsa002321.27857604
39RNA polymerase_Homo sapiens_hsa030201.25510614
40Renin secretion_Homo sapiens_hsa049241.25141319
41Gastric acid secretion_Homo sapiens_hsa049711.24172849
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22685604
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.19359950
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18905376
45Tryptophan metabolism_Homo sapiens_hsa003801.15561601
46Fanconi anemia pathway_Homo sapiens_hsa034601.15047492
47Gap junction_Homo sapiens_hsa045401.13074557
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11783267
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.09727053
50GnRH signaling pathway_Homo sapiens_hsa049121.08597370
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07957222
52Peroxisome_Homo sapiens_hsa041461.07466210
53Ovarian steroidogenesis_Homo sapiens_hsa049131.03083782
54Steroid biosynthesis_Homo sapiens_hsa001001.02223503
55Oxytocin signaling pathway_Homo sapiens_hsa049211.01898643
56Calcium signaling pathway_Homo sapiens_hsa040201.01556307
57Fat digestion and absorption_Homo sapiens_hsa049751.01516218
58RNA degradation_Homo sapiens_hsa030181.01018595
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99873631
60Rheumatoid arthritis_Homo sapiens_hsa053230.99283470
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98555236
62Oocyte meiosis_Homo sapiens_hsa041140.96731840
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96274635
64Phagosome_Homo sapiens_hsa041450.94856055
65ErbB signaling pathway_Homo sapiens_hsa040120.94220175
66Dorso-ventral axis formation_Homo sapiens_hsa043200.93820275
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92482172
68Selenocompound metabolism_Homo sapiens_hsa004500.90852127
69Sphingolipid metabolism_Homo sapiens_hsa006000.88775688
70Melanogenesis_Homo sapiens_hsa049160.83339198
71Homologous recombination_Homo sapiens_hsa034400.81429189
72cAMP signaling pathway_Homo sapiens_hsa040240.80420062
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79368253
74Mineral absorption_Homo sapiens_hsa049780.78698355
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78609248
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.77685816
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76445810
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74541446
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74501411
80Arachidonic acid metabolism_Homo sapiens_hsa005900.73970640
81Estrogen signaling pathway_Homo sapiens_hsa049150.73133281
82Ras signaling pathway_Homo sapiens_hsa040140.72712418
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.72583619
84Hedgehog signaling pathway_Homo sapiens_hsa043400.72484553
85Renal cell carcinoma_Homo sapiens_hsa052110.71220782
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69914464
87Retinol metabolism_Homo sapiens_hsa008300.69665819
88Chemical carcinogenesis_Homo sapiens_hsa052040.69161063
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69001466
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67382976
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67173639
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66356719
93Asthma_Homo sapiens_hsa053100.64994987
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64095157
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64072953
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.63860736
97beta-Alanine metabolism_Homo sapiens_hsa004100.62935175
98Metabolic pathways_Homo sapiens_hsa011000.62676075
99MAPK signaling pathway_Homo sapiens_hsa040100.62274610
100Circadian rhythm_Homo sapiens_hsa047100.61266574
101Wnt signaling pathway_Homo sapiens_hsa043100.61238360
102Tight junction_Homo sapiens_hsa045300.60789887
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.59234068
104Alcoholism_Homo sapiens_hsa050340.59162078
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59130898
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58782228
107Pancreatic secretion_Homo sapiens_hsa049720.58189639
108Choline metabolism in cancer_Homo sapiens_hsa052310.58027678
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56313503
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55631116
111Sulfur metabolism_Homo sapiens_hsa009200.55031599
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54001705
113Fatty acid metabolism_Homo sapiens_hsa012120.52858888
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52726729
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.51547091
116Type I diabetes mellitus_Homo sapiens_hsa049400.51483452
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51379038
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51071145
119Fatty acid biosynthesis_Homo sapiens_hsa000610.50876832
120Fatty acid elongation_Homo sapiens_hsa000620.49683673
121Linoleic acid metabolism_Homo sapiens_hsa005910.49280809
122Type II diabetes mellitus_Homo sapiens_hsa049300.49112506
123Ribosome_Homo sapiens_hsa030100.48569916
124ABC transporters_Homo sapiens_hsa020100.48311642
125Regulation of autophagy_Homo sapiens_hsa041400.47930014
126Colorectal cancer_Homo sapiens_hsa052100.47553795
127One carbon pool by folate_Homo sapiens_hsa006700.46779191
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45991322
129Basal cell carcinoma_Homo sapiens_hsa052170.45741043
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44900734
131Endocytosis_Homo sapiens_hsa041440.44525657
132Glioma_Homo sapiens_hsa052140.44360320
133Thyroid hormone synthesis_Homo sapiens_hsa049180.43315340
134Hippo signaling pathway_Homo sapiens_hsa043900.41714743
135Non-homologous end-joining_Homo sapiens_hsa034500.40974905
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40344493
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39313354
138Purine metabolism_Homo sapiens_hsa002300.39028893
139Protein export_Homo sapiens_hsa030600.39017933
140Dilated cardiomyopathy_Homo sapiens_hsa054140.38980949
141Endometrial cancer_Homo sapiens_hsa052130.37600835
142Arginine and proline metabolism_Homo sapiens_hsa003300.37347739
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35397764
144Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34352240
145Butanoate metabolism_Homo sapiens_hsa006500.34259230
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.33130093

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