GDPD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. This protein may have a role in osteoblast differentiation and growth. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.59846328
2establishment of skin barrier (GO:0061436)6.08258099
3presynaptic membrane assembly (GO:0097105)5.58226381
4regulation of water loss via skin (GO:0033561)5.49993882
5keratinization (GO:0031424)4.89138409
6presynaptic membrane organization (GO:0097090)4.82929662
7multicellular organismal water homeostasis (GO:0050891)4.49587483
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.40976107
9neuronal stem cell maintenance (GO:0097150)4.38429880
10keratinocyte proliferation (GO:0043616)4.22141357
11hemidesmosome assembly (GO:0031581)4.15044424
12L-serine metabolic process (GO:0006563)4.13267531
13neuron fate determination (GO:0048664)3.88302925
14otic vesicle formation (GO:0030916)3.82310199
15cholesterol biosynthetic process (GO:0006695)3.81058054
16keratinocyte differentiation (GO:0030216)3.77104882
17nonmotile primary cilium assembly (GO:0035058)3.72907527
18water homeostasis (GO:0030104)3.67112011
19sphingoid metabolic process (GO:0046519)3.65427634
20epithelial cilium movement (GO:0003351)3.58609635
21sterol biosynthetic process (GO:0016126)3.55694127
22establishment of protein localization to mitochondrial membrane (GO:0090151)3.55531811
23regulation of cell proliferation involved in kidney development (GO:1901722)3.49210643
24negative regulation of sodium ion transport (GO:0010766)3.37316763
25negative regulation of axon extension involved in axon guidance (GO:0048843)3.36882216
26lateral sprouting from an epithelium (GO:0060601)3.32441237
27regulation of axon extension involved in axon guidance (GO:0048841)3.32392567
28intraciliary transport (GO:0042073)3.32145809
29tongue development (GO:0043586)3.31499992
30atrioventricular valve morphogenesis (GO:0003181)3.26325090
31cellular potassium ion homeostasis (GO:0030007)3.23150857
32regulation of ruffle assembly (GO:1900027)3.21110801
33neuron cell-cell adhesion (GO:0007158)3.18954477
34retinal ganglion cell axon guidance (GO:0031290)3.17317588
35regulation of penile erection (GO:0060405)3.15914633
36positive regulation of interleukin-8 secretion (GO:2000484)3.15456120
37one-carbon compound transport (GO:0019755)3.11624806
38chaperone-mediated protein transport (GO:0072321)3.11504540
39G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.08832535
40cilium movement (GO:0003341)3.08492536
41somite development (GO:0061053)3.07683988
42pyrimidine nucleobase catabolic process (GO:0006208)3.04704248
43diol metabolic process (GO:0034311)3.04670954
44calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.04441305
45radial glial cell differentiation (GO:0060019)3.04329980
46retinal rod cell development (GO:0046548)3.03673779
47virion attachment to host cell (GO:0019062)3.03585928
48adhesion of symbiont to host cell (GO:0044650)3.03585928
49regulation of non-canonical Wnt signaling pathway (GO:2000050)3.02917858
50regulation of axon guidance (GO:1902667)3.02052536
51cellular response to cholesterol (GO:0071397)3.01291391
52serine family amino acid catabolic process (GO:0009071)2.99262308
53epidermal cell differentiation (GO:0009913)2.98217407
54response to auditory stimulus (GO:0010996)2.97821384
55keratinocyte development (GO:0003334)2.97821007
56ribosomal small subunit assembly (GO:0000028)2.97701254
57peptide cross-linking (GO:0018149)2.97379160
58long-chain fatty acid biosynthetic process (GO:0042759)2.97058857
59atrial cardiac muscle cell action potential (GO:0086014)2.97022628
60linoleic acid metabolic process (GO:0043651)2.94780476
61negative regulation of astrocyte differentiation (GO:0048712)2.94175541
62epidermis development (GO:0008544)2.93832215
63sphingosine metabolic process (GO:0006670)2.93602673
64regulation of phospholipase A2 activity (GO:0032429)2.91917689
65chondroitin sulfate catabolic process (GO:0030207)2.91791748
66negative regulation of transcription regulatory region DNA binding (GO:2000678)2.91499120
67potassium ion import (GO:0010107)2.90921153
68negative regulation of axon guidance (GO:1902668)2.89176778
69water-soluble vitamin biosynthetic process (GO:0042364)2.89101065
70regulation of fever generation (GO:0031620)2.88545622
71dermatan sulfate biosynthetic process (GO:0030208)2.86181258
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.84841387
73planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84109372
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84012067
75midbrain development (GO:0030901)2.83882222
76glucosamine-containing compound catabolic process (GO:1901072)2.83551615
77sodium ion export (GO:0071436)2.82531156
78establishment of planar polarity (GO:0001736)2.81591424
79establishment of tissue polarity (GO:0007164)2.81591424
80endocardial cushion morphogenesis (GO:0003203)2.78318687
81cysteine metabolic process (GO:0006534)2.77143468
82skin morphogenesis (GO:0043589)2.76848235
83serine family amino acid biosynthetic process (GO:0009070)2.76817471
84dermatan sulfate metabolic process (GO:0030205)2.76106923
85negative regulation of glial cell differentiation (GO:0045686)2.73219492
86axon ensheathment in central nervous system (GO:0032291)2.69500104
87central nervous system myelination (GO:0022010)2.69500104
88vitamin biosynthetic process (GO:0009110)2.67680079
89renal absorption (GO:0070293)2.67419007
90negative regulation of oligodendrocyte differentiation (GO:0048715)2.66770590
91smoothened signaling pathway (GO:0007224)2.66074272
92lung-associated mesenchyme development (GO:0060484)2.64893565
93intermediate filament organization (GO:0045109)2.63642438
94vocalization behavior (GO:0071625)2.62370470
95cilium morphogenesis (GO:0060271)2.62232633
96C4-dicarboxylate transport (GO:0015740)2.61809499
97regulation of glomerular filtration (GO:0003093)2.60401338
98notochord development (GO:0030903)2.58892461
99positive regulation of glomerulus development (GO:0090193)2.57046849
100limb bud formation (GO:0060174)2.54716296
101negative regulation of keratinocyte proliferation (GO:0010839)2.54099623
102nucleobase catabolic process (GO:0046113)2.53136869
103regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52982767
104cell proliferation in forebrain (GO:0021846)2.52208066
105regulation of astrocyte differentiation (GO:0048710)2.51305964
106cranial nerve development (GO:0021545)2.50324097
107axonal fasciculation (GO:0007413)2.48673327
108energy coupled proton transport, down electrochemical gradient (GO:0015985)2.48147885
109ATP synthesis coupled proton transport (GO:0015986)2.48147885
110regulation of heat generation (GO:0031650)2.47841185
111serine family amino acid metabolic process (GO:0009069)2.47130323
112cilium or flagellum-dependent cell motility (GO:0001539)2.46442292
113fat-soluble vitamin biosynthetic process (GO:0042362)2.46259093
114Notch signaling involved in heart development (GO:0061314)2.45341786
115regulation of transforming growth factor beta1 production (GO:0032908)2.44650139
116regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.43327946
117cell surface receptor signaling pathway involved in heart development (GO:0061311)2.42701709
118heart trabecula morphogenesis (GO:0061384)2.42516863
119cellular response to sterol (GO:0036315)2.42103205
120mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42071740
121positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.41149836
122transmission of nerve impulse (GO:0019226)2.40906223
123axonemal dynein complex assembly (GO:0070286)2.40386483
124dendritic spine morphogenesis (GO:0060997)2.40109779
125drinking behavior (GO:0042756)2.39589457
126nephron tubule morphogenesis (GO:0072078)2.39463393
127nephron epithelium morphogenesis (GO:0072088)2.39463393
128isoprenoid biosynthetic process (GO:0008299)2.39335964
129phospholipid efflux (GO:0033700)2.39240728
130bundle of His cell to Purkinje myocyte communication (GO:0086069)2.39126488
131potassium ion homeostasis (GO:0055075)2.38536252
132oligodendrocyte differentiation (GO:0048709)2.38220358
133positive regulation of astrocyte differentiation (GO:0048711)2.37994160
134neuron projection extension involved in neuron projection guidance (GO:1902284)2.37493064
135axon extension involved in axon guidance (GO:0048846)2.37493064
136regulation of development, heterochronic (GO:0040034)2.37360220
137phospholipid scrambling (GO:0017121)2.37280587
138digestive tract morphogenesis (GO:0048546)2.37001260
139glomerulus development (GO:0032835)2.36914295
140alanine transport (GO:0032328)2.36165357
141protein neddylation (GO:0045116)2.35812728
142auditory behavior (GO:0031223)2.35752284
143cilium assembly (GO:0042384)2.35625996
144negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.35574121
145layer formation in cerebral cortex (GO:0021819)2.35539072
146heart valve formation (GO:0003188)2.34928204
147dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.34402162
148positive regulation of male gonad development (GO:2000020)2.33986401
149cilium organization (GO:0044782)2.33738971
150mechanoreceptor differentiation (GO:0042490)2.33678794
151epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.32441689
152response to gravity (GO:0009629)2.32318994
153mesenchyme morphogenesis (GO:0072132)2.31756356
154paraxial mesoderm development (GO:0048339)2.31007397
155regulation of Rac GTPase activity (GO:0032314)2.30949903
156prepulse inhibition (GO:0060134)2.28457389
157fatty acid elongation (GO:0030497)2.28337099
158cell-cell signaling involved in cell fate commitment (GO:0045168)2.28178269
159heart valve morphogenesis (GO:0003179)2.28108414
160forebrain neuron differentiation (GO:0021879)2.27647204
161glomerular filtration (GO:0003094)2.27405254
162kidney morphogenesis (GO:0060993)2.26977608
163convergent extension (GO:0060026)2.26376543
164regulation of posttranscriptional gene silencing (GO:0060147)2.26116950
165regulation of gene silencing by miRNA (GO:0060964)2.26116950
166regulation of gene silencing by RNA (GO:0060966)2.26116950
167viral transcription (GO:0019083)2.26105574
168myelination in peripheral nervous system (GO:0022011)2.25636721
169peripheral nervous system axon ensheathment (GO:0032292)2.25636721
170positive regulation of potassium ion transmembrane transport (GO:1901381)2.25628435
171cGMP-mediated signaling (GO:0019934)2.24495554
172renal filtration (GO:0097205)2.24068456
173adhesion of symbiont to host (GO:0044406)2.23944442
174positive regulation of kidney development (GO:0090184)2.23732912
175chemical homeostasis within a tissue (GO:0048875)2.22513421
176postsynaptic membrane organization (GO:0001941)2.20543629
177regulation of glomerulus development (GO:0090192)2.19883036
178regulation of somitogenesis (GO:0014807)2.19471871
179cellular sodium ion homeostasis (GO:0006883)2.19402798
180negative regulation of homotypic cell-cell adhesion (GO:0034111)2.19349860
181membrane repolarization (GO:0086009)2.19188798
182angiotensin maturation (GO:0002003)2.17933302
183gland morphogenesis (GO:0022612)2.17926138
184tonic smooth muscle contraction (GO:0014820)2.15844257
185regulation of heart rate by cardiac conduction (GO:0086091)2.15617242
186proline transport (GO:0015824)2.15554253
187regulation of kidney development (GO:0090183)2.15212392
188cell proliferation involved in metanephros development (GO:0072203)2.14574754
189cerebral cortex neuron differentiation (GO:0021895)2.13971736
190artery smooth muscle contraction (GO:0014824)2.13905552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.38908729
2RBPJ_22232070_ChIP-Seq_NCS_Mouse2.99281309
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.68454531
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62166394
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54243802
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39542966
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39008090
8ZNF274_21170338_ChIP-Seq_K562_Hela2.34748804
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.28408256
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.22240033
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20179184
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07038486
13EZH2_22144423_ChIP-Seq_EOC_Human2.06693506
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02568928
15FUS_26573619_Chip-Seq_HEK293_Human2.02331567
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.00748076
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00107597
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99959491
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99769685
20AR_21572438_ChIP-Seq_LNCaP_Human1.99378380
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.99062220
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98540113
23IGF1R_20145208_ChIP-Seq_DFB_Human1.96481088
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93624478
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92644244
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92554867
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92554867
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91732868
29TAF15_26573619_Chip-Seq_HEK293_Human1.91629532
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90259609
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.88943577
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88391897
33SOX2_16153702_ChIP-ChIP_HESCs_Human1.86625884
34EWS_26573619_Chip-Seq_HEK293_Human1.82951631
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.82124122
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79269792
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79187113
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73247463
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.72357144
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.71935174
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.70679233
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65516346
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.62479732
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61504379
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61475080
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61195225
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.59918701
48VDR_22108803_ChIP-Seq_LS180_Human1.59479614
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59056031
50DROSHA_22980978_ChIP-Seq_HELA_Human1.58665817
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56304253
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55655448
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.55160725
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.54206828
55P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48044952
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.45997225
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44822708
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.42872204
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41598135
60TBX3_20139965_ChIP-Seq_MESCs_Mouse1.41386867
61RXR_22108803_ChIP-Seq_LS180_Human1.40854513
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40779481
63TP53_18474530_ChIP-ChIP_U2OS_Human1.39873534
64TBX3_20139965_ChIP-Seq_ESCs_Mouse1.39658147
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39098381
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37679775
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37105651
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37060225
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.36338350
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36194558
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35956974
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35956974
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35956974
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.35150775
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33282100
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.31541363
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30595061
78GBX2_23144817_ChIP-Seq_PC3_Human1.30294010
79POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.29672599
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28747868
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.28426457
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27936202
83MYC_18940864_ChIP-ChIP_HL60_Human1.23713515
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.23629398
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.23305899
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23116599
87AHR_22903824_ChIP-Seq_MCF-7_Human1.21210695
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.19845894
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19387342
90ELK1_19687146_ChIP-ChIP_HELA_Human1.19175513
91BCAT_22108803_ChIP-Seq_LS180_Human1.16297378
92CJUN_26792858_Chip-Seq_BT549_Human1.15955995
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.14723658
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14519670
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.12733920
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12321822
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12167407
98TP53_16413492_ChIP-PET_HCT116_Human1.10721800
99* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10517497
100SOX2_20726797_ChIP-Seq_SW620_Human1.10301216
101SOX9_26525672_Chip-Seq_HEART_Mouse1.10265123
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09253257
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09253257
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09191114
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08168629
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07586387
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07232449
108* KLF5_25053715_ChIP-Seq_YYC3_Human1.06362582
109TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05675452
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02248041
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00943105
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00808434
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00541290
114TP63_23658742_ChIP-Seq_EP156T_Human1.00292622
115MYC_18555785_ChIP-Seq_MESCs_Mouse1.00154472
116GATA1_26923725_Chip-Seq_HPCs_Mouse0.99858944
117BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99808198
118AR_25329375_ChIP-Seq_VCAP_Human0.99072216
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99067928
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97412928
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96887809
122CLOCK_20551151_ChIP-Seq_293T_Human0.96741621
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.96462652
124IRF1_19129219_ChIP-ChIP_H3396_Human0.96354427
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96134883
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96006381
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95058577
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94704436
129NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94559113
130NANOG_19829295_ChIP-Seq_ESCs_Human0.94464427
131SOX2_19829295_ChIP-Seq_ESCs_Human0.94464427
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93556711
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.92281267
134CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92046007
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91336126
136RUNX2_22187159_ChIP-Seq_PCA_Human0.90930020
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89607390
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88307220
139RUNX1_27514584_Chip-Seq_MCF-7_Human0.87827224
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87651743
141CTCF_27219007_Chip-Seq_Bcells_Human0.86646934
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86582005
143PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86217765
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.85473732
145DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85418000
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.84198527
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84143130
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84143130
149* P300_19829295_ChIP-Seq_ESCs_Human0.84056915
150REST_21632747_ChIP-Seq_MESCs_Mouse0.81824978
151SMAD4_21799915_ChIP-Seq_A2780_Human0.80906706
152SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80600682
153SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80600682
154RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79808334
155TP63_22573176_ChIP-Seq_HFKS_Human0.79166282
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78494789
157TCF4_22108803_ChIP-Seq_LS180_Human0.76198942
158ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.75493024
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.74527722
160KDM2B_26808549_Chip-Seq_K562_Human0.74427792
161ISL1_27105846_Chip-Seq_CPCs_Mouse0.74225413
162TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73771719
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.73673528
164TOP2B_26459242_ChIP-Seq_MCF-7_Human0.73249054
165FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72681589
166WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.72497307
167RNF2_27304074_Chip-Seq_NSC_Mouse0.71817219
168CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.71162535
169EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.70166712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.42291729
2MP0002796_impaired_skin_barrier5.80564002
3MP0003941_abnormal_skin_development4.48590921
4MP0005275_abnormal_skin_tensile4.14694074
5MP0002254_reproductive_system_inflammat3.31235855
6MP0005501_abnormal_skin_physiology3.29740903
7MP0002653_abnormal_ependyma_morphology2.88707959
8MP0004858_abnormal_nervous_system2.85581805
9MP0000566_synostosis2.83372060
10MP0010678_abnormal_skin_adnexa2.82105304
11MP0003136_yellow_coat_color2.76785282
12MP0006292_abnormal_olfactory_placode2.72467363
13MP0000383_abnormal_hair_follicle2.68587957
14MP0001529_abnormal_vocalization2.60879169
15MP0002938_white_spotting2.50363297
16MP0003122_maternal_imprinting2.39960197
17MP0002060_abnormal_skin_morphology2.35316657
18MP0002098_abnormal_vibrissa_morphology2.33616629
19MP0001216_abnormal_epidermal_layer2.32566936
20MP0010771_integument_phenotype2.24442389
21MP0002638_abnormal_pupillary_reflex2.23860816
22MP0000579_abnormal_nail_morphology2.19911709
23MP0001293_anophthalmia2.13437086
24MP0000647_abnormal_sebaceous_gland2.10902736
25MP0000467_abnormal_esophagus_morphology2.07201129
26MP0004381_abnormal_hair_follicle1.98627218
27MP0003690_abnormal_glial_cell1.88982296
28MP0005377_hearing/vestibular/ear_phenot1.88845151
29MP0003878_abnormal_ear_physiology1.88845151
30MP0001485_abnormal_pinna_reflex1.80879968
31MP0003453_abnormal_keratinocyte_physiol1.78036332
32MP0004133_heterotaxia1.72770980
33MP0002009_preneoplasia1.70705057
34MP0003011_delayed_dark_adaptation1.66313952
35MP0000762_abnormal_tongue_morphology1.64161515
36MP0004947_skin_inflammation1.59755515
37MP0005670_abnormal_white_adipose1.56896312
38MP0009384_cardiac_valve_regurgitation1.56474946
39MP0009379_abnormal_foot_pigmentation1.55788861
40MP0003880_abnormal_central_pattern1.52177679
41MP0000026_abnormal_inner_ear1.51880486
42MP0004272_abnormal_basement_membrane1.50767280
43MP0003937_abnormal_limbs/digits/tail_de1.46675471
44MP0002736_abnormal_nociception_after1.43981609
45MP0004142_abnormal_muscle_tone1.43851626
46MP0004185_abnormal_adipocyte_glucose1.42082032
47MP0000377_abnormal_hair_follicle1.41241137
48MP0006072_abnormal_retinal_apoptosis1.38505181
49MP0003183_abnormal_peptide_metabolism1.36968624
50MP0000427_abnormal_hair_cycle1.34589118
51MP0004019_abnormal_vitamin_homeostasis1.30848224
52MP0002697_abnormal_eye_size1.29104632
53MP0000631_abnormal_neuroendocrine_gland1.28863218
54MP0002282_abnormal_trachea_morphology1.25315248
55MP0001286_abnormal_eye_development1.23857184
56MP0010030_abnormal_orbit_morphology1.22587775
57MP0008877_abnormal_DNA_methylation1.22458913
58MP0009780_abnormal_chondrocyte_physiolo1.21144650
59MP0003121_genomic_imprinting1.20998881
60MP0008058_abnormal_DNA_repair1.18954269
61MP0001346_abnormal_lacrimal_gland1.18662211
62MP0001299_abnormal_eye_distance/1.18349487
63MP0002751_abnormal_autonomic_nervous1.18125763
64MP0003890_abnormal_embryonic-extraembry1.16141880
65MP0001501_abnormal_sleep_pattern1.14902567
66MP0005174_abnormal_tail_pigmentation1.14345974
67MP0006276_abnormal_autonomic_nervous1.12126027
68MP0009053_abnormal_anal_canal1.12010525
69MP0002734_abnormal_mechanical_nocicepti1.11580986
70MP0005551_abnormal_eye_electrophysiolog1.10844092
71MP0001963_abnormal_hearing_physiology1.10729949
72MP0000955_abnormal_spinal_cord1.10516350
73MP0003705_abnormal_hypodermis_morpholog1.10302173
74MP0000462_abnormal_digestive_system1.09199768
75MP0009931_abnormal_skin_appearance1.09106082
76MP0004147_increased_porphyrin_level1.07703967
77MP0005253_abnormal_eye_physiology1.07590935
78MP0003938_abnormal_ear_development1.07211524
79MP0001984_abnormal_olfaction1.06779004
80MP0005391_vision/eye_phenotype1.05356616
81MP0002092_abnormal_eye_morphology1.04796815
82MP0001191_abnormal_skin_condition1.04735526
83MP0002822_catalepsy1.02999525
84MP0003718_maternal_effect1.01482075
85MP0005248_abnormal_Harderian_gland1.00901689
86MP0003329_amyloid_beta_deposits1.00708370
87MP0003566_abnormal_cell_adhesion1.00684119
88MP0002089_abnormal_postnatal_growth/wei0.99299255
89MP0003119_abnormal_digestive_system0.99106827
90MP0003861_abnormal_nervous_system0.99043240
91MP0002095_abnormal_skin_pigmentation0.97777543
92MP0002152_abnormal_brain_morphology0.95557509
93MP0002752_abnormal_somatic_nervous0.94527310
94MP0003567_abnormal_fetal_cardiomyocyte0.93353608
95MP0005187_abnormal_penis_morphology0.93278207
96MP0002111_abnormal_tail_morphology0.92437800
97MP0000538_abnormal_urinary_bladder0.91832138
98MP0008932_abnormal_embryonic_tissue0.91674062
99MP0000778_abnormal_nervous_system0.90617156
100MP0002102_abnormal_ear_morphology0.90606457
101MP0003045_fibrosis0.90464244
102MP0001324_abnormal_eye_pigmentation0.90315216
103MP0004859_abnormal_synaptic_plasticity0.88089329
104MP0000372_irregular_coat_pigmentation0.87450496
105MP0003075_altered_response_to0.86606209
106MP0003279_aneurysm0.86368154
107MP0002928_abnormal_bile_duct0.85921556
108MP0000537_abnormal_urethra_morphology0.84677933
109MP0001958_emphysema0.83736562
110MP0005423_abnormal_somatic_nervous0.83618179
111MP0001340_abnormal_eyelid_morphology0.83075582
112MP0008789_abnormal_olfactory_epithelium0.82993260
113MP0005195_abnormal_posterior_eye0.82609711
114MP0001188_hyperpigmentation0.82216974
115MP0003635_abnormal_synaptic_transmissio0.82160292
116MP0005666_abnormal_adipose_tissue0.81953212
117MP0001502_abnormal_circadian_rhythm0.79919596
118MP0002557_abnormal_social/conspecific_i0.79233173
119MP0002067_abnormal_sensory_capabilities0.78253174
120MP0008438_abnormal_cutaneous_collagen0.78226882
121MP0005394_taste/olfaction_phenotype0.77785678
122MP0005499_abnormal_olfactory_system0.77785678
123MP0002882_abnormal_neuron_morphology0.77459901
124MP0003283_abnormal_digestive_organ0.76243625
125MP0005085_abnormal_gallbladder_physiolo0.76086986
126MP0001177_atelectasis0.74829038
127MP0004885_abnormal_endolymph0.74536598
128MP0002735_abnormal_chemical_nociception0.73915008
129MP0000049_abnormal_middle_ear0.73647200
130MP0003385_abnormal_body_wall0.73307254
131MP0001243_abnormal_dermal_layer0.72836425
132MP0000428_abnormal_craniofacial_morphol0.72301309
133MP0000367_abnormal_coat/_hair0.71957946
134MP0005164_abnormal_response_to0.71629831
135MP0002064_seizures0.71431067
136MP0005508_abnormal_skeleton_morphology0.70518416
137MP0009745_abnormal_behavioral_response0.69184526
138MP0004270_analgesia0.69115165
139MP0005409_darkened_coat_color0.68702573
140MP0010386_abnormal_urinary_bladder0.67523762
141MP0001440_abnormal_grooming_behavior0.65795236
142MP0008569_lethality_at_weaning0.65434236
143MP0004134_abnormal_chest_morphology0.63489227
144MP0002063_abnormal_learning/memory/cond0.63334620
145MP0005171_absent_coat_pigmentation0.62372550
146MP0001968_abnormal_touch/_nociception0.61753171
147MP0005257_abnormal_intraocular_pressure0.61676284
148MP0002233_abnormal_nose_morphology0.61669980
149MP0009046_muscle_twitch0.61660017
150MP0002090_abnormal_vision0.61520986
151MP0003755_abnormal_palate_morphology0.60309755
152MP0009250_abnormal_appendicular_skeleto0.59839855
153MP0005645_abnormal_hypothalamus_physiol0.59477863
154MP0000604_amyloidosis0.59327852
155MP0003942_abnormal_urinary_system0.59040413
156MP0002234_abnormal_pharynx_morphology0.56677788
157MP0004742_abnormal_vestibular_system0.56666202
158MP0001486_abnormal_startle_reflex0.56314285
159MP0002249_abnormal_larynx_morphology0.56195620
160MP0002572_abnormal_emotion/affect_behav0.56044642
161MP0005646_abnormal_pituitary_gland0.55232428
162MP0003634_abnormal_glial_cell0.54962021
163MP0001664_abnormal_digestion0.53752749

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)4.83165226
2Hypotrichosis (HP:0001006)4.67133461
3Aplasia of the phalanges of the hand (HP:0009802)4.64878522
4Aplasia involving bones of the extremities (HP:0009825)4.64878522
5Aplasia involving bones of the upper limbs (HP:0009823)4.64878522
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.43806322
7Fragile nails (HP:0001808)4.26762439
8Plantar hyperkeratosis (HP:0007556)3.93181838
9Right ventricular cardiomyopathy (HP:0011663)3.92946176
10Abnormality of the axillary hair (HP:0100134)3.89562746
11Abnormality of secondary sexual hair (HP:0009888)3.89562746
12Onycholysis (HP:0001806)3.87216791
13Increased IgE level (HP:0003212)3.77701694
14Abnormality of the labia minora (HP:0012880)3.77185397
15Parakeratosis (HP:0001036)3.63989133
16Alopecia of scalp (HP:0002293)3.54682289
17Ectropion (HP:0000656)3.50743779
18Megalencephaly (HP:0001355)3.43586544
19True hermaphroditism (HP:0010459)3.41602883
20Woolly hair (HP:0002224)3.41342118
21Follicular hyperkeratosis (HP:0007502)3.37873757
22Hyperglycinemia (HP:0002154)3.37289074
23Palmoplantar hyperkeratosis (HP:0000972)3.32358078
24Erythema (HP:0010783)3.31636363
25Milia (HP:0001056)3.27864717
26Hyperglycinuria (HP:0003108)3.14236617
27Absent septum pellucidum (HP:0001331)3.10124575
28Palmar hyperkeratosis (HP:0010765)3.08421751
29Abnormality of glycine metabolism (HP:0010895)3.07770894
30Abnormality of serine family amino acid metabolism (HP:0010894)3.07770894
31Short hallux (HP:0010109)3.03579438
32Lip pit (HP:0100267)3.03323415
33Esophageal atresia (HP:0002032)3.02184264
34Abnormality of nail color (HP:0100643)2.98000061
35Atrophic scars (HP:0001075)2.92594565
36Concave nail (HP:0001598)2.91667771
37Pancreatic fibrosis (HP:0100732)2.87757561
38Optic nerve hypoplasia (HP:0000609)2.80596648
39Hypohidrosis (HP:0000966)2.77481455
40Neonatal short-limb short stature (HP:0008921)2.77017089
41Hemiparesis (HP:0001269)2.75530481
42Maternal diabetes (HP:0009800)2.74872885
43Gastrointestinal atresia (HP:0002589)2.74121801
44Corneal erosion (HP:0200020)2.73675513
45Colon cancer (HP:0003003)2.73653731
46Aplasia/Hypoplasia of the hallux (HP:0008362)2.69623826
47Genital tract atresia (HP:0001827)2.68605046
48Abnormality of the diencephalon (HP:0010662)2.67461112
49Medial flaring of the eyebrow (HP:0010747)2.65027499
50Polyphagia (HP:0002591)2.63412284
51Vaginal atresia (HP:0000148)2.61457815
52Gait imbalance (HP:0002141)2.61455159
53Congenital primary aphakia (HP:0007707)2.61239431
54Pili torti (HP:0003777)2.59768404
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.59162500
56Curly hair (HP:0002212)2.59010882
57Broad foot (HP:0001769)2.55804316
58Anophthalmia (HP:0000528)2.55732662
59Hemivertebrae (HP:0002937)2.54235772
60Split foot (HP:0001839)2.49955232
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.46049849
62Morphological abnormality of the middle ear (HP:0008609)2.45989935
63Median cleft lip (HP:0000161)2.45862352
64Abnormality of the septum pellucidum (HP:0007375)2.45122700
65Erythroderma (HP:0001019)2.44565014
66Hyporeflexia of lower limbs (HP:0002600)2.41552945
67Nail dystrophy (HP:0008404)2.41038733
68Nephrogenic diabetes insipidus (HP:0009806)2.40353822
69Rib fusion (HP:0000902)2.36211970
70Abnormal ciliary motility (HP:0012262)2.35221708
71Pterygium (HP:0001059)2.34676209
72Partial duplication of thumb phalanx (HP:0009944)2.33747142
73Bifid tongue (HP:0010297)2.33644883
74Reticulocytopenia (HP:0001896)2.33038693
75Pancreatic cysts (HP:0001737)2.30908861
76Sclerocornea (HP:0000647)2.30861653
77Increased hepatocellular lipid droplets (HP:0006565)2.28918642
78Bilateral microphthalmos (HP:0007633)2.27896331
79Premature rupture of membranes (HP:0001788)2.27239001
80Acanthosis nigricans (HP:0000956)2.23433630
81Short tibia (HP:0005736)2.23429107
82Hepatoblastoma (HP:0002884)2.20751174
83Abnormality of midbrain morphology (HP:0002418)2.19706412
84Molar tooth sign on MRI (HP:0002419)2.19706412
85Natal tooth (HP:0000695)2.19211848
86Fragile skin (HP:0001030)2.16650314
87Lipid accumulation in hepatocytes (HP:0006561)2.15993077
88Bronchomalacia (HP:0002780)2.15771444
89Short middle phalanx of the 5th finger (HP:0004220)2.15433974
90Humeroradial synostosis (HP:0003041)2.14995293
91Synostosis involving the elbow (HP:0003938)2.14995293
92Spastic diplegia (HP:0001264)2.14984827
93Advanced eruption of teeth (HP:0006288)2.14173407
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.13826736
95Postaxial foot polydactyly (HP:0001830)2.13446944
96Postaxial hand polydactyly (HP:0001162)2.11294158
97Abnormality of molar morphology (HP:0011070)2.10058326
98Abnormality of molar (HP:0011077)2.10058326
99Abnormality of the dental pulp (HP:0006479)2.10040981
100Bifid scrotum (HP:0000048)2.09592779
101Abnormality of the dental root (HP:0006486)2.08281293
102Taurodontia (HP:0000679)2.08281293
103Abnormality of permanent molar morphology (HP:0011071)2.08281293
104Abnormality of the middle phalanges of the toes (HP:0010183)2.08203565
105Confusion (HP:0001289)2.07909701
106Abnormal respiratory epithelium morphology (HP:0012253)2.07103623
107Abnormal respiratory motile cilium morphology (HP:0005938)2.07103623
108Hypoplastic labia majora (HP:0000059)2.07080390
109Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.06851715
110Nephronophthisis (HP:0000090)2.06541930
111Aplasia/Hypoplasia of the tibia (HP:0005772)2.06140331
112Cortical dysplasia (HP:0002539)2.05085176
113Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.04617894
114Renal hypoplasia (HP:0000089)2.00959856
115Neurofibrillary tangles (HP:0002185)1.99601521
116Mesangial abnormality (HP:0001966)1.99476942
117Supernumerary spleens (HP:0009799)1.99311666
118Preaxial hand polydactyly (HP:0001177)1.98832269
119Popliteal pterygium (HP:0009756)1.98325467
120Abnormal blistering of the skin (HP:0008066)1.97919454
121Partial duplication of the phalanx of hand (HP:0009999)1.96634999
122Poor suck (HP:0002033)1.96101070
123Specific learning disability (HP:0001328)1.95129968
124Stenosis of the external auditory canal (HP:0000402)1.95007914
125Trigonocephaly (HP:0000243)1.94489833
126Hypoplasia of dental enamel (HP:0006297)1.94384630
127Thick nail (HP:0001805)1.93857713
128Abnormality of serum amino acid levels (HP:0003112)1.93147034
129Poor coordination (HP:0002370)1.92969063
130Distal lower limb muscle weakness (HP:0009053)1.91048635
131Focal motor seizures (HP:0011153)1.90980412
132Anencephaly (HP:0002323)1.90778796
133Holoprosencephaly (HP:0001360)1.89657719
134Large for gestational age (HP:0001520)1.89320163
135Patchy hypopigmentation of hair (HP:0011365)1.88515121
136Acute encephalopathy (HP:0006846)1.88419715
137Coronal craniosynostosis (HP:0004440)1.87816452
138Vertebral hypoplasia (HP:0008417)1.87785278
139Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87785278
140Aortic dissection (HP:0002647)1.87684918
141Palmoplantar keratoderma (HP:0000982)1.87409952
142Hypoplastic pelvis (HP:0008839)1.85413036
143Intestinal atresia (HP:0011100)1.85256238
144Abnormality of the phalanges of the 5th finger (HP:0004213)1.84681758
145Abnormal eating behavior (HP:0100738)1.84582917
146Acute necrotizing encephalopathy (HP:0006965)1.83963873
147Abnormality of the labia majora (HP:0012881)1.83443114
148Abnormal number of erythroid precursors (HP:0012131)1.82529800
149Exercise-induced muscle cramps (HP:0003710)1.82328413
150Septo-optic dysplasia (HP:0100842)1.81385303
151Ventricular tachycardia (HP:0004756)1.81343641
152Cutaneous syndactyly (HP:0012725)1.81221375
153Blepharitis (HP:0000498)1.80571723
154Hypodontia (HP:0000668)1.80246998
155White forelock (HP:0002211)1.79653854
156Preaxial foot polydactyly (HP:0001841)1.79333181
157Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.78939096
158Occipital encephalocele (HP:0002085)1.78125516
159Sparse eyelashes (HP:0000653)1.76909441
160Abnormal lung lobation (HP:0002101)1.76231295
161Short 4th metacarpal (HP:0010044)1.75417355
162Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75417355
163Tarsal synostosis (HP:0008368)1.73877777
164Postnatal microcephaly (HP:0005484)1.73676197
165Pruritus (HP:0000989)1.73248606
166Abnormal respiratory motile cilium physiology (HP:0012261)1.73209744
167Cutaneous finger syndactyly (HP:0010554)1.72737133
168Abnormality of cells of the erythroid lineage (HP:0012130)1.72321442
169Rhinitis (HP:0012384)1.72182007
170Mildly elevated creatine phosphokinase (HP:0008180)1.72152894
171Sparse scalp hair (HP:0002209)1.70163107
172Widely patent fontanelles and sutures (HP:0004492)1.69987392
173Pseudobulbar signs (HP:0002200)1.69722743
174Choanal stenosis (HP:0000452)1.69431025
175Increased variability in muscle fiber diameter (HP:0003557)1.69294887
176Renal Fanconi syndrome (HP:0001994)1.68003582
177Broad metatarsal (HP:0001783)1.67997152
178Abnormality of the middle phalanges of the hand (HP:0009833)1.66767118
179Tibial bowing (HP:0002982)1.66277578
180Labial hypoplasia (HP:0000066)1.65626039
181Hamartoma of the eye (HP:0010568)1.65043951
182Synostosis involving bones of the feet (HP:0009140)1.64715231
183Synostosis involving bones of the lower limbs (HP:0009138)1.64715231
184Abnormality of the 2nd finger (HP:0004100)1.64623582
185Absent toe (HP:0010760)1.63656149
186Dehydration (HP:0001944)1.62068180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.81961906
2LMTK23.78472841
3PNCK3.63123811
4NTRK23.29490770
5MST42.66268230
6FER2.59715627
7EPHB22.56905388
8MST1R2.56200730
9PIK3CA2.44637157
10RIPK12.39034742
11PDGFRA2.18861638
12TNIK2.15296102
13BCKDK2.14898424
14WNK32.13686180
15ERN12.06740315
16DYRK22.06693523
17FRK2.06435680
18CDK192.05666358
19PHKG12.04713237
20PHKG22.04713237
21STK241.99230973
22MAP3K21.97572731
23WEE11.80613829
24VRK11.77938439
25CDC42BPA1.76390856
26VRK21.74976173
27SIK11.71882423
28CASK1.67960440
29MAP4K21.65436291
30MAP3K31.63989517
31PBK1.63594569
32PLK21.63169784
33MKNK21.56047326
34PLK31.54922685
35DDR21.53942565
36CSNK1G21.51017877
37DMPK1.49893863
38PAK31.47583031
39MKNK11.45319967
40MAP3K121.44502052
41BMPR1B1.38119070
42DYRK31.37557472
43CDC71.31101409
44PINK11.29712011
45MAPKAPK31.29085529
46MYLK1.27388826
47SRPK11.26751842
48BUB11.26429229
49ROCK11.25015899
50EPHA31.24725800
51CSNK1G11.24551301
52STK161.21779681
53ZAK1.20579901
54ADRBK11.19383247
55MARK11.18906557
56TAOK11.17752684
57CSNK1G31.15524417
58TAF11.15242765
59TRIM281.14853959
60EPHA41.14324689
61MAP2K71.13811507
62FGFR21.12983194
63WNK41.11233335
64NUAK11.08739134
65NTRK31.07328203
66ROCK21.03262325
67STK391.02051812
68PRKCG1.00881945
69TNK21.00167492
70TTN1.00054113
71PDK20.99106712
72CSNK1A1L0.98771809
73FGR0.96879902
74LIMK10.93289355
75LATS10.89117543
76ACVR1B0.88964717
77MAP3K90.87280683
78PASK0.86901758
79LRRK20.86133494
80CAMK1G0.85382325
81TESK10.85190455
82MAP3K40.85132857
83NEK10.84338399
84LATS20.83938395
85RIPK40.80734853
86TGFBR10.80314816
87GRK10.80304573
88MINK10.79693498
89OXSR10.79599051
90PLK10.79393074
91MET0.79321182
92MAP3K100.78442805
93TTK0.74965229
94MAP2K20.74655915
95CDK50.74122588
96KIT0.73949479
97TYRO30.73773628
98NME10.73541102
99MAP3K10.73021073
100CAMK1D0.71169360
101ERBB20.70730085
102RPS6KA40.70295595
103EPHB10.69518209
104PIK3CG0.69127413
105GRK70.69054845
106MAPK150.68540037
107MAP3K70.67856978
108PRKCE0.67545405
109TIE10.65983342
110NTRK10.65474794
111MAP2K40.63885635
112PDGFRB0.63100279
113PTK20.62206044
114MAPK130.61728118
115SGK20.61536809
116SGK2230.61345555
117SGK4940.61345555
118MAP3K140.59445875
119SRC0.58479113
120STK38L0.58298863
121ADRBK20.57832725
122SGK10.57586076
123PLK40.56705729
124PRKCI0.56169562
125FGFR10.55803237
126DYRK1A0.55657246
127PRKD30.55401432
128STK100.54372100
129BMX0.53677454
130PTK60.51900436
131STK110.50403584
132SGK30.50168027
133UHMK10.49944942
134MAPK120.48975415
135MAP2K10.48973306
136CDK30.48781374
137INSRR0.48240464
138PAK20.48187623
139DYRK1B0.47304978
140MAPKAPK50.46790763
141ATR0.45248077
142PAK60.45070437
143PRKCA0.44843335
144BCR0.44476552
145MAP3K110.44175364
146CAMK2A0.41552706
147CAMK2D0.41363306
148ERBB30.41030140
149PIM20.39876970
150CSNK1A10.38973362
151FGFR30.37839056
152MAP3K130.37684466
153FYN0.36155835
154ATM0.34113368
155CSNK1E0.34085428
156PRKDC0.34037691
157EPHA20.33924821
158PRKACB0.33713967
159KSR10.32825026
160CHEK20.32356576
161PKN10.32158064
162RPS6KB20.31971513
163FLT30.31568975
164NLK0.31567331
165MAPKAPK20.31475264
166RPS6KA20.30793065
167CSNK2A10.30587363
168AURKB0.29512560
169MUSK0.29225902
170CAMK10.28278474

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.61716960
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.87870361
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40031405
4Sphingolipid metabolism_Homo sapiens_hsa006002.37324045
5Protein export_Homo sapiens_hsa030602.22276094
6Ribosome_Homo sapiens_hsa030102.16591459
7Oxidative phosphorylation_Homo sapiens_hsa001902.11016586
8Mineral absorption_Homo sapiens_hsa049782.10072529
9Propanoate metabolism_Homo sapiens_hsa006402.04242536
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98910275
11Parkinsons disease_Homo sapiens_hsa050121.95976076
12Bile secretion_Homo sapiens_hsa049761.95163524
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94556496
14Butanoate metabolism_Homo sapiens_hsa006501.78446869
15Axon guidance_Homo sapiens_hsa043601.73489413
16Fatty acid biosynthesis_Homo sapiens_hsa000611.67289190
17Fat digestion and absorption_Homo sapiens_hsa049751.65912218
18Renin secretion_Homo sapiens_hsa049241.62564788
19Gastric acid secretion_Homo sapiens_hsa049711.62548548
20Basal cell carcinoma_Homo sapiens_hsa052171.61855110
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58498437
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54600568
23Dorso-ventral axis formation_Homo sapiens_hsa043201.52950578
24Huntingtons disease_Homo sapiens_hsa050161.51086509
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49338921
26Salivary secretion_Homo sapiens_hsa049701.46025391
27Nicotine addiction_Homo sapiens_hsa050331.44224171
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.35373442
29RNA polymerase_Homo sapiens_hsa030201.30951057
30Peroxisome_Homo sapiens_hsa041461.30223020
31Arginine and proline metabolism_Homo sapiens_hsa003301.29815352
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29335013
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.27305499
34Proteasome_Homo sapiens_hsa030501.27285535
35Cardiac muscle contraction_Homo sapiens_hsa042601.25799021
36Melanogenesis_Homo sapiens_hsa049161.25187063
37Glutamatergic synapse_Homo sapiens_hsa047241.24775911
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24334337
39Folate biosynthesis_Homo sapiens_hsa007901.23736166
40Protein digestion and absorption_Homo sapiens_hsa049741.22632866
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21789222
42Vitamin digestion and absorption_Homo sapiens_hsa049771.21746927
43GnRH signaling pathway_Homo sapiens_hsa049121.20902204
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20094548
45Mismatch repair_Homo sapiens_hsa034301.18118341
46Alzheimers disease_Homo sapiens_hsa050101.17131558
47Fanconi anemia pathway_Homo sapiens_hsa034601.16819395
48ECM-receptor interaction_Homo sapiens_hsa045121.16741240
49Gap junction_Homo sapiens_hsa045401.16537862
50GABAergic synapse_Homo sapiens_hsa047271.16495770
51Circadian entrainment_Homo sapiens_hsa047131.16358596
52Serotonergic synapse_Homo sapiens_hsa047261.16173414
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15888153
54Linoleic acid metabolism_Homo sapiens_hsa005911.15441892
55Long-term depression_Homo sapiens_hsa047301.15268000
56Fatty acid metabolism_Homo sapiens_hsa012121.13254369
57Biosynthesis of amino acids_Homo sapiens_hsa012301.13103519
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12887017
59PPAR signaling pathway_Homo sapiens_hsa033201.11921346
60Renin-angiotensin system_Homo sapiens_hsa046141.10556246
61Pancreatic secretion_Homo sapiens_hsa049721.08631257
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08551396
63Pyruvate metabolism_Homo sapiens_hsa006201.07501833
64Tight junction_Homo sapiens_hsa045301.07198846
65Hedgehog signaling pathway_Homo sapiens_hsa043401.06549511
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06291692
67Ether lipid metabolism_Homo sapiens_hsa005651.03578299
68Calcium signaling pathway_Homo sapiens_hsa040201.03144645
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02614444
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01467858
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01068266
72Homologous recombination_Homo sapiens_hsa034401.00595450
73Insulin secretion_Homo sapiens_hsa049110.99866201
74Arachidonic acid metabolism_Homo sapiens_hsa005900.99662024
75Nitrogen metabolism_Homo sapiens_hsa009100.98326270
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.97643073
77Base excision repair_Homo sapiens_hsa034100.97114458
78Hippo signaling pathway_Homo sapiens_hsa043900.95691519
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94785767
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94695361
81Carbon metabolism_Homo sapiens_hsa012000.94683310
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94268282
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93736547
84Retinol metabolism_Homo sapiens_hsa008300.91585471
85beta-Alanine metabolism_Homo sapiens_hsa004100.90044066
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89483625
87Cocaine addiction_Homo sapiens_hsa050300.88971463
88Ovarian steroidogenesis_Homo sapiens_hsa049130.88495195
89Glutathione metabolism_Homo sapiens_hsa004800.88119319
90Fatty acid elongation_Homo sapiens_hsa000620.87764166
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.87432060
92Spliceosome_Homo sapiens_hsa030400.86335776
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.85154407
94Sulfur relay system_Homo sapiens_hsa041220.84998037
95RNA degradation_Homo sapiens_hsa030180.84412430
96Vitamin B6 metabolism_Homo sapiens_hsa007500.84382462
97Chemical carcinogenesis_Homo sapiens_hsa052040.84212915
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83876794
99Fatty acid degradation_Homo sapiens_hsa000710.83547702
100Non-homologous end-joining_Homo sapiens_hsa034500.83460189
101Metabolic pathways_Homo sapiens_hsa011000.78151570
102DNA replication_Homo sapiens_hsa030300.76378465
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76292281
104Proteoglycans in cancer_Homo sapiens_hsa052050.74956282
105cAMP signaling pathway_Homo sapiens_hsa040240.74856303
106Adherens junction_Homo sapiens_hsa045200.74008367
107Oxytocin signaling pathway_Homo sapiens_hsa049210.73893109
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73218739
109Phototransduction_Homo sapiens_hsa047440.73107863
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.72251138
111Bladder cancer_Homo sapiens_hsa052190.71343977
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71102086
113Basal transcription factors_Homo sapiens_hsa030220.70987703
114Tryptophan metabolism_Homo sapiens_hsa003800.70900981
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.70475711
116Arginine biosynthesis_Homo sapiens_hsa002200.70270648
117Morphine addiction_Homo sapiens_hsa050320.70247272
118Notch signaling pathway_Homo sapiens_hsa043300.70082773
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69067782
120Choline metabolism in cancer_Homo sapiens_hsa052310.69036277
121Amoebiasis_Homo sapiens_hsa051460.68979851
122Nucleotide excision repair_Homo sapiens_hsa034200.68158803
123Steroid biosynthesis_Homo sapiens_hsa001000.67926293
124African trypanosomiasis_Homo sapiens_hsa051430.67615083
125MicroRNAs in cancer_Homo sapiens_hsa052060.67551058
126ABC transporters_Homo sapiens_hsa020100.67535563
127Olfactory transduction_Homo sapiens_hsa047400.67015428
128Cholinergic synapse_Homo sapiens_hsa047250.67012958
129Glioma_Homo sapiens_hsa052140.66912630
130Taste transduction_Homo sapiens_hsa047420.66642402
131ErbB signaling pathway_Homo sapiens_hsa040120.65757146
132Ras signaling pathway_Homo sapiens_hsa040140.65465982
133TGF-beta signaling pathway_Homo sapiens_hsa043500.65193611
134Long-term potentiation_Homo sapiens_hsa047200.64966054
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64959473
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64948135
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64814495
138Selenocompound metabolism_Homo sapiens_hsa004500.64809892
139Sulfur metabolism_Homo sapiens_hsa009200.63921136
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63893799
141Wnt signaling pathway_Homo sapiens_hsa043100.62409499
142Caffeine metabolism_Homo sapiens_hsa002320.61655806
143Estrogen signaling pathway_Homo sapiens_hsa049150.60583451
144Focal adhesion_Homo sapiens_hsa045100.59391240
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.59268964
146Rap1 signaling pathway_Homo sapiens_hsa040150.59258198
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58843266
148Purine metabolism_Homo sapiens_hsa002300.58581358
149Melanoma_Homo sapiens_hsa052180.58184983
150Histidine metabolism_Homo sapiens_hsa003400.58072906
151Dilated cardiomyopathy_Homo sapiens_hsa054140.56764688
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56689427
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.56521398
154Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56276799
155Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54779377
156Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53910200
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53230208
158Amphetamine addiction_Homo sapiens_hsa050310.53126927
159Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52680424
160Leukocyte transendothelial migration_Homo sapiens_hsa046700.52633172
161Circadian rhythm_Homo sapiens_hsa047100.52103483
162RNA transport_Homo sapiens_hsa030130.51237677
163Glycerolipid metabolism_Homo sapiens_hsa005610.49852918
164Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48133617
165One carbon pool by folate_Homo sapiens_hsa006700.48033552
166mRNA surveillance pathway_Homo sapiens_hsa030150.46874279
167Galactose metabolism_Homo sapiens_hsa000520.45802332
168Steroid hormone biosynthesis_Homo sapiens_hsa001400.44836364
169Pyrimidine metabolism_Homo sapiens_hsa002400.43696566

Most similar genes based on co-expression Upload to Enrichr

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