GDPD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.72410614
2acrosome reaction (GO:0007340)9.67718941
3cell-cell recognition (GO:0009988)9.60974623
4motile cilium assembly (GO:0044458)9.47228084
5cell wall macromolecule metabolic process (GO:0044036)9.40704162
6cell wall macromolecule catabolic process (GO:0016998)9.40704162
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.22549335
8male meiosis (GO:0007140)9.19884980
9reproduction (GO:0000003)9.03313431
10cilium movement (GO:0003341)8.98334822
11spermatid development (GO:0007286)8.80038187
12synaptonemal complex organization (GO:0070193)8.18911909
13synaptonemal complex assembly (GO:0007130)7.90503546
14regulation of cilium movement (GO:0003352)7.44815690
15single fertilization (GO:0007338)7.39732236
16DNA methylation involved in gamete generation (GO:0043046)7.28834399
17sperm capacitation (GO:0048240)6.76278446
18male meiosis I (GO:0007141)6.40253234
19fertilization (GO:0009566)6.32375389
20negative regulation of inclusion body assembly (GO:0090084)5.74370622
21chromosome organization involved in meiosis (GO:0070192)5.69281849
22spermatogenesis (GO:0007283)5.60966699
23ventricular system development (GO:0021591)5.59986621
24male gamete generation (GO:0048232)5.59080798
25meiotic nuclear division (GO:0007126)5.39990686
26meiotic cell cycle (GO:0051321)5.35702052
27meiosis I (GO:0007127)5.19756028
28gamete generation (GO:0007276)5.15629758
29germ cell development (GO:0007281)5.15063645
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.10356793
31seminiferous tubule development (GO:0072520)5.01597004
32cellular ketone body metabolic process (GO:0046950)4.91033643
33microtubule depolymerization (GO:0007019)4.89453781
34response to pheromone (GO:0019236)4.81723896
35cell recognition (GO:0008037)4.80013986
36protein localization to cilium (GO:0061512)4.76890337
37calcium ion-dependent exocytosis (GO:0017156)4.61551592
38microtubule severing (GO:0051013)4.59330211
39ketone body metabolic process (GO:1902224)4.53416529
40organic cation transport (GO:0015695)4.47988459
41resolution of meiotic recombination intermediates (GO:0000712)4.45823139
42regulation of inclusion body assembly (GO:0090083)4.40584660
43regulation of microtubule-based movement (GO:0060632)4.33064042
44gene silencing by RNA (GO:0031047)4.32233663
45left/right pattern formation (GO:0060972)4.14129080
46genitalia morphogenesis (GO:0035112)4.07199396
47multicellular organismal reproductive process (GO:0048609)4.03438433
48monoubiquitinated protein deubiquitination (GO:0035520)3.88672379
49intraciliary transport (GO:0042073)3.84184258
50negative regulation of organelle assembly (GO:1902116)3.80510725
51cellular response to ATP (GO:0071318)3.77054563
52fucose catabolic process (GO:0019317)3.76228908
53L-fucose metabolic process (GO:0042354)3.76228908
54L-fucose catabolic process (GO:0042355)3.76228908
55regulation of centriole replication (GO:0046599)3.73372553
56axoneme assembly (GO:0035082)3.70164134
57microtubule-based movement (GO:0007018)3.64528618
58synapsis (GO:0007129)3.49578364
59positive regulation of meiosis (GO:0045836)3.49027051
60chaperone-mediated protein complex assembly (GO:0051131)3.46096664
61meiotic cell cycle process (GO:1903046)3.45896841
62protein polyglutamylation (GO:0018095)3.41806926
63mannosylation (GO:0097502)3.40388851
64regulation of meiosis I (GO:0060631)3.40336491
65negative regulation of telomere maintenance (GO:0032205)3.38913800
66regulation of protein polyubiquitination (GO:1902914)3.35409919
67multicellular organismal development (GO:0007275)3.35287740
68detection of light stimulus involved in sensory perception (GO:0050962)3.35168467
69detection of light stimulus involved in visual perception (GO:0050908)3.35168467
70reciprocal DNA recombination (GO:0035825)3.34475189
71reciprocal meiotic recombination (GO:0007131)3.34475189
72protein K63-linked deubiquitination (GO:0070536)3.33451881
73spermatid nucleus differentiation (GO:0007289)3.33310340
74centriole replication (GO:0007099)3.32562096
75positive regulation of meiotic cell cycle (GO:0051446)3.32216068
76leukotriene biosynthetic process (GO:0019370)3.30432571
77glomerular visceral epithelial cell development (GO:0072015)3.23516882
78centriole assembly (GO:0098534)3.21822275
79behavioral response to nicotine (GO:0035095)3.19895506
80cilium organization (GO:0044782)3.19472487
81carnitine transmembrane transport (GO:1902603)3.19389395
82UDP-N-acetylglucosamine metabolic process (GO:0006047)3.17613393
83amino-acid betaine transport (GO:0015838)3.17008304
84carnitine transport (GO:0015879)3.17008304
85polyol catabolic process (GO:0046174)3.13541327
86DNA deamination (GO:0045006)3.12853873
87lactate metabolic process (GO:0006089)3.09192879
88cilium assembly (GO:0042384)3.03687219
89inositol phosphate catabolic process (GO:0071545)3.01165482
90tryptophan catabolic process (GO:0006569)3.00773975
91indole-containing compound catabolic process (GO:0042436)3.00773975
92indolalkylamine catabolic process (GO:0046218)3.00773975
93phosphorylated carbohydrate dephosphorylation (GO:0046838)2.97469174
94inositol phosphate dephosphorylation (GO:0046855)2.97469174
95establishment of protein localization to Golgi (GO:0072600)2.96741780
96nucleoside diphosphate phosphorylation (GO:0006165)2.96698762
97regulation of spindle checkpoint (GO:0090231)2.96125567
98tachykinin receptor signaling pathway (GO:0007217)2.94716002
99mitotic sister chromatid cohesion (GO:0007064)2.92173204
100cellular component assembly involved in morphogenesis (GO:0010927)2.91764283
101glycerol ether metabolic process (GO:0006662)2.90318224
102dopamine transport (GO:0015872)2.87663396
103neuronal action potential (GO:0019228)2.84712531
104cilium morphogenesis (GO:0060271)2.83566262
105rRNA catabolic process (GO:0016075)2.82088520
106gene silencing (GO:0016458)2.81682949
107indolalkylamine metabolic process (GO:0006586)2.80998894
108glomerular epithelial cell development (GO:0072310)2.80846967
109regulation of hexokinase activity (GO:1903299)2.79468624
110regulation of glucokinase activity (GO:0033131)2.79468624
111protein targeting to Golgi (GO:0000042)2.79346094
112somite rostral/caudal axis specification (GO:0032525)2.78324775
113glycerophospholipid catabolic process (GO:0046475)2.75321266
114protein K48-linked deubiquitination (GO:0071108)2.75115250
115DNA methylation (GO:0006306)2.75053981
116DNA alkylation (GO:0006305)2.75053981
117negative regulation of execution phase of apoptosis (GO:1900118)2.73053009
118Golgi to endosome transport (GO:0006895)2.70598957
119protein K11-linked deubiquitination (GO:0035871)2.70403376
120peptidyl-glutamic acid modification (GO:0018200)2.70249561
121detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67329616
122ether metabolic process (GO:0018904)2.66357103
123aromatic amino acid family catabolic process (GO:0009074)2.66341891
124negative regulation of DNA repair (GO:0045738)2.64858890
125sister chromatid cohesion (GO:0007062)2.64631377
126photoreceptor cell maintenance (GO:0045494)2.62562780
127maturation of 5.8S rRNA (GO:0000460)2.62516075
128reflex (GO:0060004)2.62245527
129dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.61645603
130primary amino compound metabolic process (GO:1901160)2.61019628
131regulation of chromatin binding (GO:0035561)2.60834445
132retinal cone cell development (GO:0046549)2.60368269
133brain morphogenesis (GO:0048854)2.56909186
134chromosome condensation (GO:0030261)2.56728492
135nuclear pore complex assembly (GO:0051292)2.56195606
136DNA packaging (GO:0006323)2.55635822
137microtubule polymerization or depolymerization (GO:0031109)2.54177931
138positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.50284999
139GTP biosynthetic process (GO:0006183)2.49950327
140negative regulation of heart rate (GO:0010459)2.49369747
141tryptophan metabolic process (GO:0006568)2.48984074
142protein localization to Golgi apparatus (GO:0034067)2.47090626
143regulation of podosome assembly (GO:0071801)2.46513497
144cAMP catabolic process (GO:0006198)2.46459356
145negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44281042
146gamma-aminobutyric acid transport (GO:0015812)2.43221529
147retrograde transport, vesicle recycling within Golgi (GO:0000301)2.43129812
148insulin secretion (GO:0030073)2.42157696
149preassembly of GPI anchor in ER membrane (GO:0016254)2.41873530
150nucleus organization (GO:0006997)2.39980266
151sequestering of metal ion (GO:0051238)2.39889178
152protein refolding (GO:0042026)2.39147992
153single strand break repair (GO:0000012)2.36518399
154kynurenine metabolic process (GO:0070189)2.35865099
155signal peptide processing (GO:0006465)2.35442537
156proline transport (GO:0015824)2.34692565
157cilium or flagellum-dependent cell motility (GO:0001539)18.0696907
158fusion of sperm to egg plasma membrane (GO:0007342)13.1409575
159piRNA metabolic process (GO:0034587)12.0477651
160sperm motility (GO:0030317)11.5972164
161multicellular organism reproduction (GO:0032504)11.1036482
162axonemal dynein complex assembly (GO:0070286)11.0417052
163sperm-egg recognition (GO:0035036)10.7328008
164acrosome assembly (GO:0001675)10.5956741
165epithelial cilium movement (GO:0003351)10.0966486
166plasma membrane fusion (GO:0045026)10.0309152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.17798788
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.65980221
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.76620259
4IGF1R_20145208_ChIP-Seq_DFB_Human3.12913372
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.04625425
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.86506356
7GBX2_23144817_ChIP-Seq_PC3_Human2.75368019
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71075217
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.66247993
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30214346
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29447219
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24400345
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19603553
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.12753757
15ZNF274_21170338_ChIP-Seq_K562_Hela2.04186671
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01935129
17P300_19829295_ChIP-Seq_ESCs_Human2.01640824
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2036478
19ELK4_26923725_Chip-Seq_MESODERM_Mouse1.92459955
20* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89979579
21EWS_26573619_Chip-Seq_HEK293_Human1.87888197
22VDR_22108803_ChIP-Seq_LS180_Human1.81299569
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.72054498
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.69545125
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68671842
26CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.65979663
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65429845
28STAT3_23295773_ChIP-Seq_U87_Human1.65141099
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64680419
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64475255
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63911282
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61480267
33AR_25329375_ChIP-Seq_VCAP_Human1.58760101
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.56306055
35REST_21632747_ChIP-Seq_MESCs_Mouse1.56118611
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.55169645
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.53807671
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.53434491
39TP53_22573176_ChIP-Seq_HFKS_Human1.53100364
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.52460765
41STAT1_17558387_ChIP-Seq_HELA_Human1.50503660
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47680788
43* TAL1_26923725_Chip-Seq_HPCs_Mouse1.46289350
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45764387
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44284348
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.43295202
47NANOG_19829295_ChIP-Seq_ESCs_Human1.42611409
48SOX2_19829295_ChIP-Seq_ESCs_Human1.42611409
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41147576
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.38218952
51KDM2B_26808549_Chip-Seq_REH_Human1.38179790
52TCF4_22108803_ChIP-Seq_LS180_Human1.37514459
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37196277
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.37196277
55RUNX2_22187159_ChIP-Seq_PCA_Human1.35214177
56* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34171972
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32628719
58GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.31446849
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.31298892
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30671391
61CBP_20019798_ChIP-Seq_JUKART_Human1.30446027
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30446027
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30324625
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29869718
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29708914
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.29130667
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27622998
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27501969
69AR_20517297_ChIP-Seq_VCAP_Human1.27243831
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26709731
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.26663116
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25550002
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.25459259
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24277763
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.24231451
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.23736511
77P53_22387025_ChIP-Seq_ESCs_Mouse1.23329970
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.21023310
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20040920
80P300_18555785_Chip-Seq_ESCs_Mouse1.19864380
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19274341
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.18665419
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17992130
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17976600
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17976600
86FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17180155
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17002123
88* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16677853
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16357764
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15833260
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14828546
92TAF15_26573619_Chip-Seq_HEK293_Human1.14521355
93CDX2_22108803_ChIP-Seq_LS180_Human1.13850520
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13541061
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13117284
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.13065637
97RNF2_27304074_Chip-Seq_NSC_Mouse1.12997356
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12117332
99AR_21572438_ChIP-Seq_LNCaP_Human1.11950190
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10987928
101STAT3_18555785_Chip-Seq_ESCs_Mouse1.10686860
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.09648804
103KLF4_18555785_Chip-Seq_ESCs_Mouse1.09371311
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08359960
105HOXB7_26014856_ChIP-Seq_BT474_Human1.07703188
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07225793
107GF1_26923725_Chip-Seq_HPCs_Mouse1.06065133
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05993559
109BCAT_22108803_ChIP-Seq_LS180_Human1.05818052
110HTT_18923047_ChIP-ChIP_STHdh_Human1.05634838
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05491386
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05230562
113TCF4_23295773_ChIP-Seq_U87_Human1.04588153
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04492430
115SOX2_22085726_ChIP-Seq_NPCs_Mouse1.04260355
116GATA3_21867929_ChIP-Seq_TH1_Mouse1.04065754
117GATA3_21867929_ChIP-Seq_CD8_Mouse1.03552632
118LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.02271631
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02271162
120NCOR_22424771_ChIP-Seq_293T_Human1.01015683
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.00820717
122RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00262133
123* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99843495
124SMAD4_21799915_ChIP-Seq_A2780_Human0.99811951
125FUS_26573619_Chip-Seq_HEK293_Human0.99467209
126SOX2_21211035_ChIP-Seq_LN229_Gbm0.99455236
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.99207076
128* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98834490
129CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98744430
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98630272
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98506088
132ER_23166858_ChIP-Seq_MCF-7_Human0.98402705
133PU1_27457419_Chip-Seq_LIVER_Mouse0.98306734
134GABP_17652178_ChIP-ChIP_JURKAT_Human0.98301203
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96301609
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.95877575
137P53_21459846_ChIP-Seq_SAOS-2_Human0.95177603
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.93520286
139ZFX_18555785_Chip-Seq_ESCs_Mouse0.93467169
140SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93097004
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92215971
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91254508
143SOX9_26525672_Chip-Seq_HEART_Mouse0.90904487
144TBL1_22424771_ChIP-Seq_293T_Human0.90831444
145FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89508749
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89226972
147NMYC_18555785_Chip-Seq_ESCs_Mouse0.89135847
148CTCF_18555785_Chip-Seq_ESCs_Mouse0.88938433
149RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88798066
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88622218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.91908158
2MP0001929_abnormal_gametogenesis5.45868286
3MP0008877_abnormal_DNA_methylation5.32890914
4MP0002653_abnormal_ependyma_morphology3.90813793
5MP0002210_abnormal_sex_determination3.84974063
6MP0003195_calcinosis3.38014134
7MP0001145_abnormal_male_reproductive3.23492438
8MP0005645_abnormal_hypothalamus_physiol3.23173593
9MP0002161_abnormal_fertility/fecundity3.21979810
10MP0002638_abnormal_pupillary_reflex2.85422366
11MP0000653_abnormal_sex_gland2.82410768
12MP0005623_abnormal_meninges_morphology2.55208659
13MP0005379_endocrine/exocrine_gland_phen2.49770826
14MP0002163_abnormal_gland_morphology2.18588619
15MP0004147_increased_porphyrin_level2.06336986
16MP0002837_dystrophic_cardiac_calcinosis2.02600265
17MP0005410_abnormal_fertilization14.6379780
18MP0002160_abnormal_reproductive_system1.93358627
19MP0010386_abnormal_urinary_bladder1.88585537
20MP0008057_abnormal_DNA_replication1.81647996
21MP0004142_abnormal_muscle_tone1.81584178
22MP0002139_abnormal_hepatobiliary_system1.70792808
23MP0000372_irregular_coat_pigmentation1.70633781
24MP0002909_abnormal_adrenal_gland1.63019291
25MP0009046_muscle_twitch1.62061223
26MP0002822_catalepsy1.61600841
27MP0008872_abnormal_physiological_respon1.57718146
28MP0002282_abnormal_trachea_morphology1.49600114
29MP0001986_abnormal_taste_sensitivity1.44028831
30MP0000013_abnormal_adipose_tissue1.42867056
31MP0005670_abnormal_white_adipose1.41257522
32MP0003646_muscle_fatigue1.38123696
33MP0004043_abnormal_pH_regulation1.36907747
34MP0001501_abnormal_sleep_pattern1.36762485
35MP0002693_abnormal_pancreas_physiology1.36503744
36MP0006276_abnormal_autonomic_nervous1.35662790
37MP0010094_abnormal_chromosome_stability1.33427710
38MP0008875_abnormal_xenobiotic_pharmacok1.28844697
39MP0005647_abnormal_sex_gland1.27964861
40MP0008058_abnormal_DNA_repair1.26092057
41MP0002234_abnormal_pharynx_morphology1.22055353
42MP0005646_abnormal_pituitary_gland1.21884306
43MP0003718_maternal_effect1.17596050
44MP0001944_abnormal_pancreas_morphology1.16327382
45MP0004885_abnormal_endolymph1.16087159
46MP0002938_white_spotting1.15694556
47MP0001502_abnormal_circadian_rhythm1.14509818
48MP0005332_abnormal_amino_acid1.13444388
49MP0001905_abnormal_dopamine_level1.12210213
50MP0000631_abnormal_neuroendocrine_gland1.11333772
51MP0001919_abnormal_reproductive_system1.07579358
52MP0001486_abnormal_startle_reflex1.06318869
53MP0004233_abnormal_muscle_weight1.05773682
54MP0001970_abnormal_pain_threshold1.04776267
55MP0010329_abnormal_lipoprotein_level1.02652118
56MP0005075_abnormal_melanosome_morpholog1.02469633
57MP0005408_hypopigmentation1.01997924
58MP0001765_abnormal_ion_homeostasis1.00783871
59MP0005085_abnormal_gallbladder_physiolo0.99881377
60MP0005084_abnormal_gallbladder_morpholo0.98781819
61MP0002102_abnormal_ear_morphology0.98420599
62MP0008995_early_reproductive_senescence0.97851510
63MP0005671_abnormal_response_to0.97597336
64MP0002733_abnormal_thermal_nociception0.97180697
65MP0001764_abnormal_homeostasis0.96902161
66MP0008789_abnormal_olfactory_epithelium0.95574478
67MP0005310_abnormal_salivary_gland0.94713299
68MP0002557_abnormal_social/conspecific_i0.94442559
69MP0005389_reproductive_system_phenotype0.93516850
70MP0002078_abnormal_glucose_homeostasis0.89966333
71MP0003011_delayed_dark_adaptation0.89077163
72MP0001756_abnormal_urination0.87522906
73MP0005220_abnormal_exocrine_pancreas0.87294078
74MP0001984_abnormal_olfaction0.86943743
75MP0000569_abnormal_digit_pigmentation0.84854268
76MP0003183_abnormal_peptide_metabolism0.84382640
77MP0008007_abnormal_cellular_replicative0.84190875
78MP0004924_abnormal_behavior0.82965371
79MP0005386_behavior/neurological_phenoty0.82965371
80MP0004215_abnormal_myocardial_fiber0.82669375
81MP0002734_abnormal_mechanical_nocicepti0.82567409
82MP0000015_abnormal_ear_pigmentation0.81267034
83MP0000639_abnormal_adrenal_gland0.80522952
84MP0002229_neurodegeneration0.79936410
85MP0008961_abnormal_basal_metabolism0.79395799
86MP0002254_reproductive_system_inflammat0.79222136
87MP0003786_premature_aging0.78014550
88MP0001485_abnormal_pinna_reflex0.77641078
89MP0003252_abnormal_bile_duct0.76970205
90MP0005167_abnormal_blood-brain_barrier0.76749926
91MP0003111_abnormal_nucleus_morphology0.75869363
92MP0005377_hearing/vestibular/ear_phenot0.71885384
93MP0003878_abnormal_ear_physiology0.71885384
94MP0003329_amyloid_beta_deposits0.68233911
95MP0003879_abnormal_hair_cell0.58669147
96MP0005174_abnormal_tail_pigmentation0.57955648
97MP0002928_abnormal_bile_duct0.57615670
98MP0000358_abnormal_cell_content/0.57306175
99MP0002876_abnormal_thyroid_physiology0.56134096
100MP0003950_abnormal_plasma_membrane0.55711041
101MP0005551_abnormal_eye_electrophysiolog0.54566993
102MP0003699_abnormal_female_reproductive0.52701643
103MP0000427_abnormal_hair_cycle0.51601188
104MP0009745_abnormal_behavioral_response0.50401649
105MP0010307_abnormal_tumor_latency0.49695450
106MP0002971_abnormal_brown_adipose0.48176918
107MP0002736_abnormal_nociception_after0.47189130
108MP0004270_analgesia0.47051992
109MP0001440_abnormal_grooming_behavior0.46675925
110MP0001851_eye_inflammation0.43659009
111MP0005253_abnormal_eye_physiology0.42152186
112MP0001968_abnormal_touch/_nociception0.41817142
113MP0004808_abnormal_hematopoietic_stem0.41224121
114MP0001727_abnormal_embryo_implantation0.40163886
115MP0001119_abnormal_female_reproductive0.39322693
116MP0004134_abnormal_chest_morphology0.39055090
117MP0003635_abnormal_synaptic_transmissio0.37612966
118MP0003633_abnormal_nervous_system0.37273762
119MP0005397_hematopoietic_system_phenotyp0.36519477
120MP0001545_abnormal_hematopoietic_system0.36519477
121MP0005636_abnormal_mineral_homeostasis0.34508334
122MP0002152_abnormal_brain_morphology0.34141515
123MP0005451_abnormal_body_composition0.33941793
124MP0003631_nervous_system_phenotype0.33810662
125MP0004145_abnormal_muscle_electrophysio0.33791054
126MP0001324_abnormal_eye_pigmentation0.33730963
127MP0006072_abnormal_retinal_apoptosis0.33634244
128MP0000604_amyloidosis0.32721924
129MP0002572_abnormal_emotion/affect_behav0.32656983
130MP0004859_abnormal_synaptic_plasticity0.32520844
131MP0003045_fibrosis0.32326477
132MP0002064_seizures0.31940599
133MP0003861_abnormal_nervous_system0.31860278
134MP0008569_lethality_at_weaning0.31581815
135MP0000462_abnormal_digestive_system0.30159513
136MP0002269_muscular_atrophy0.29079901
137MP0009115_abnormal_fat_cell0.28634778
138MP0000313_abnormal_cell_death0.28511621
139MP0004811_abnormal_neuron_physiology0.28413395
140MP0005391_vision/eye_phenotype0.27781870
141MP0003115_abnormal_respiratory_system0.27582248
142MP0003890_abnormal_embryonic-extraembry0.26943276
143MP0002272_abnormal_nervous_system0.25908795
144MP0002063_abnormal_learning/memory/cond0.25538008
145MP0002067_abnormal_sensory_capabilities0.25241394
146MP0000778_abnormal_nervous_system0.24784266
147MP0003787_abnormal_imprinting0.24759621
148MP0004019_abnormal_vitamin_homeostasis0.24040286
149MP0001661_extended_life_span0.23523844
150MP0005409_darkened_coat_color0.23408333
151MP0004036_abnormal_muscle_relaxation0.23158228
152MP0003880_abnormal_central_pattern0.22281121
153MP0001963_abnormal_hearing_physiology0.21612589
154MP0000678_abnormal_parathyroid_gland0.21153683
155MP0005666_abnormal_adipose_tissue0.20793035
156MP0005535_abnormal_body_temperature0.20607901
157MP0002735_abnormal_chemical_nociception0.20304696
158MP0002405_respiratory_system_inflammati0.19876374

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.53866875
2Abnormal respiratory motile cilium morphology (HP:0005938)8.88096744
3Abnormal respiratory epithelium morphology (HP:0012253)8.88096744
4Rhinitis (HP:0012384)8.14565066
5Abnormal ciliary motility (HP:0012262)7.79469886
6Chronic bronchitis (HP:0004469)7.06450958
7Nasal polyposis (HP:0100582)6.41214659
8Infertility (HP:0000789)6.25019686
9Abnormality of the nasal mucosa (HP:0000433)5.21654893
10Bronchiectasis (HP:0002110)4.70415464
11Nephronophthisis (HP:0000090)4.46113607
12Bronchitis (HP:0012387)4.37122097
13Hypoproteinemia (HP:0003075)3.79632711
14Abnormality of the lower motor neuron (HP:0002366)3.71469783
15Abnormality of the renal medulla (HP:0100957)3.47802385
16Recurrent sinusitis (HP:0011108)3.35880145
17Pancreatic cysts (HP:0001737)3.32459514
18Recurrent otitis media (HP:0000403)3.25465590
19Attenuation of retinal blood vessels (HP:0007843)3.24719152
20Tubulointerstitial nephritis (HP:0001970)3.10654926
21Methylmalonic acidemia (HP:0002912)3.10159771
22Gonadotropin excess (HP:0000837)2.97277925
23Type I transferrin isoform profile (HP:0003642)2.93108561
24Abnormal protein glycosylation (HP:0012346)2.91297006
25Abnormal glycosylation (HP:0012345)2.91297006
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.91297006
27Abnormal protein N-linked glycosylation (HP:0012347)2.91297006
28Abnormality of DNA repair (HP:0003254)2.88930002
29Congenital stationary night blindness (HP:0007642)2.86898260
30Male infertility (HP:0003251)2.83933186
31Amyotrophic lateral sclerosis (HP:0007354)2.77062654
32Medial flaring of the eyebrow (HP:0010747)2.72048370
33Fibular hypoplasia (HP:0003038)2.68747191
34True hermaphroditism (HP:0010459)2.68421697
35Hyperventilation (HP:0002883)2.68401164
36Abnormality of vitamin B metabolism (HP:0004340)2.63515217
37Progressive inability to walk (HP:0002505)2.60437792
38Recurrent bronchitis (HP:0002837)2.57569524
39Type II lissencephaly (HP:0007260)2.54500924
40Abnormal spermatogenesis (HP:0008669)2.51926273
41Molar tooth sign on MRI (HP:0002419)2.50003781
42Abnormality of midbrain morphology (HP:0002418)2.50003781
43Absent speech (HP:0001344)2.42133917
44Methylmalonic aciduria (HP:0012120)2.41646667
45Impaired proprioception (HP:0010831)2.39587623
46Intestinal atresia (HP:0011100)2.39367372
47Abolished electroretinogram (ERG) (HP:0000550)2.37704573
48Impulsivity (HP:0100710)2.35427295
49Abnormal rod and cone electroretinograms (HP:0008323)2.35310517
50Inability to walk (HP:0002540)2.34017557
51Chronic hepatic failure (HP:0100626)2.33305274
52Tubulointerstitial abnormality (HP:0001969)2.31596640
53Ketoacidosis (HP:0001993)2.31059178
54Chronic diarrhea (HP:0002028)2.29264535
55Tubular atrophy (HP:0000092)2.24520738
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.20362447
57Abnormality of alanine metabolism (HP:0010916)2.19460200
58Hyperalaninemia (HP:0003348)2.19460200
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19460200
60Renal cortical cysts (HP:0000803)2.19063550
61Hypothermia (HP:0002045)2.13711255
62Postaxial foot polydactyly (HP:0001830)2.12199693
63Hypoplasia of the pons (HP:0012110)2.11854406
64Absent frontal sinuses (HP:0002688)2.11242781
65Stage 5 chronic kidney disease (HP:0003774)2.10557501
66Bony spicule pigmentary retinopathy (HP:0007737)2.10343443
67Thyroiditis (HP:0100646)2.10303086
68Stomatitis (HP:0010280)2.09091919
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08057794
70Azoospermia (HP:0000027)2.07375305
71Hypophosphatemic rickets (HP:0004912)2.07220038
72J-shaped sella turcica (HP:0002680)2.06684618
73Polyuria (HP:0000103)2.04731793
74Upper motor neuron abnormality (HP:0002127)2.02059962
75Progressive macrocephaly (HP:0004481)2.01759764
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8776103
77Dynein arm defect of respiratory motile cilia (HP:0012255)12.5591811
78Absent/shortened dynein arms (HP:0200106)12.5591811
79Ketosis (HP:0001946)1.99064930
80Abnormality of the pons (HP:0007361)1.98759417
81Abnormality of the vitamin B12 metabolism (HP:0004341)1.97717475
82Reduced antithrombin III activity (HP:0001976)1.93520912
83Oligodactyly (hands) (HP:0001180)1.92533792
84Microglossia (HP:0000171)1.92446111
85Renal dysplasia (HP:0000110)1.91100842
86Abnormality of vitamin metabolism (HP:0100508)1.88985191
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88443864
88Degeneration of the lateral corticospinal tracts (HP:0002314)1.88443864
89Facial diplegia (HP:0001349)1.88206411
90Acute necrotizing encephalopathy (HP:0006965)1.88063203
91Agitation (HP:0000713)1.88003319
92Gastrointestinal atresia (HP:0002589)1.87958821
93Congenital hepatic fibrosis (HP:0002612)1.87825258
94Chronic sinusitis (HP:0011109)1.87418760
95Large for gestational age (HP:0001520)1.86387077
96Tongue fasciculations (HP:0001308)1.84670919
97Scotoma (HP:0000575)1.84177958
98Keratoconus (HP:0000563)1.83408374
99Increased corneal curvature (HP:0100692)1.83408374
100Degeneration of anterior horn cells (HP:0002398)1.82546893
101Abnormality of the anterior horn cell (HP:0006802)1.82546893
102Facial cleft (HP:0002006)1.81776713
103Supernumerary spleens (HP:0009799)1.81372472
104Fair hair (HP:0002286)1.81214970
105Aplasia/Hypoplasia of the fovea (HP:0008060)1.80691325
106Hypoplasia of the fovea (HP:0007750)1.80691325
107Abnormality of the renal cortex (HP:0011035)1.80061638
108Hypoalbuminemia (HP:0003073)1.80009902
109Abnormal albumin level (HP:0012116)1.80009902
110Spastic tetraparesis (HP:0001285)1.79994663
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.79813069
112Abnormal biliary tract morphology (HP:0012440)1.79091474
113Prolonged QT interval (HP:0001657)1.78412648
114Bilateral sensorineural hearing impairment (HP:0008619)1.77378110
115Constricted visual fields (HP:0001133)1.76773542
116Dyskinesia (HP:0100660)1.76374919
117Gait imbalance (HP:0002141)1.75581305
118Congenital primary aphakia (HP:0007707)1.75140398
119Central scotoma (HP:0000603)1.74277242
120Male pseudohermaphroditism (HP:0000037)1.73743615
121Abnormality of the labia minora (HP:0012880)1.73456764
122Decreased central vision (HP:0007663)1.72831637
123Short ribs (HP:0000773)1.72583488
124Febrile seizures (HP:0002373)1.72511582
125Concave nail (HP:0001598)1.71525287
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.70853374
127Retinal dysplasia (HP:0007973)1.70616792
128Abnormality of permanent molar morphology (HP:0011071)1.69561937
129Abnormality of the dental root (HP:0006486)1.69561937
130Taurodontia (HP:0000679)1.69561937
131Oculomotor apraxia (HP:0000657)1.68363964
132Aplasia/Hypoplasia of the fibula (HP:0006492)1.64317276
133Postaxial hand polydactyly (HP:0001162)1.63616197
134Nephroblastoma (Wilms tumor) (HP:0002667)1.62931127
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61215464
136Absent epiphyses (HP:0010577)1.61215464
137Tubulointerstitial fibrosis (HP:0005576)1.59766570
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59533431
13911 pairs of ribs (HP:0000878)1.59478717
140Abnormality of molar (HP:0011077)1.58369257
141Abnormality of molar morphology (HP:0011070)1.58369257
142Conjunctival telangiectasia (HP:0000524)1.56650830
143Gaze-evoked nystagmus (HP:0000640)1.55411723
144Abnormality of dentin (HP:0010299)1.52334187
145Embryonal renal neoplasm (HP:0011794)1.51376498
146Abnormality of the dental pulp (HP:0006479)1.50648438
147Breast carcinoma (HP:0003002)1.50021949
148Nephrogenic diabetes insipidus (HP:0009806)1.48906660
149Polydipsia (HP:0001959)1.46069777
150Abnormal drinking behavior (HP:0030082)1.46069777
151Heterotopia (HP:0002282)1.45972284
152Short thorax (HP:0010306)1.45291938
153Median cleft lip (HP:0000161)1.44013981
154Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.42586583
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.41460839
156Abnormality of ocular smooth pursuit (HP:0000617)1.40891122
157Bell-shaped thorax (HP:0001591)1.36819872
158Deformed sella turcica (HP:0002681)1.34799687
159Aplasia/Hypoplasia of the lens (HP:0008063)1.32311799
160Poor coordination (HP:0002370)1.31739700
161Genital tract atresia (HP:0001827)1.31620637
162Decreased motor nerve conduction velocity (HP:0003431)1.31092482
163Vaginal atresia (HP:0000148)1.30327834
164Cystic liver disease (HP:0006706)1.29600167
165Nephropathy (HP:0000112)1.29086479
166Abnormality of renal excretion (HP:0011036)1.28225711
167Pancreatic fibrosis (HP:0100732)1.26044261
168Broad distal phalanx of finger (HP:0009836)1.24751058
169Hypoplasia of dental enamel (HP:0006297)1.24097891
170Large eyes (HP:0001090)1.20942153
171Hemiparesis (HP:0001269)1.18408435
172Congenital malformation of the right heart (HP:0011723)1.18118684
173Double outlet right ventricle (HP:0001719)1.18118684
174Pachygyria (HP:0001302)1.17844429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.08750092
2PDK49.08750092
3FRK6.92486301
4PDK25.90632502
5TESK13.64417213
6MAP4K23.19823070
7PRKD33.01742381
8MST42.80587977
9PNCK2.72917976
10ICK2.61069768
11STK392.50912056
12WNK42.42637766
13TRIM282.36795880
14PTK2B2.31721356
15OXSR12.29273133
16ADRBK22.16108332
17NEK22.12402663
18ACVR1B2.06991939
19CCNB11.71049781
20CASK1.69092389
21INSRR1.65726032
22FGFR21.40822790
23PAK31.37477448
24PHKG21.34599894
25PHKG11.34599894
26STK381.31279763
27DAPK21.28476613
28MAPK151.26852755
29PRKCE1.23873205
30WNK11.11354632
31CAMKK21.11144794
32CSNK1G11.09274932
33ZAK1.07454912
34TXK1.07237345
35TNIK1.06604973
36IRAK10.97125719
37BCKDK0.94985711
38MAPK130.94279209
39NEK90.94054494
40TTK0.93977777
41TYRO30.92427560
42STK30.92179960
43BMPR1B0.91222365
44IKBKE0.89971217
45PIK3CG0.88194795
46EPHA30.86978410
47CDC70.85079506
48CSNK1G30.84792941
49CSNK1G20.84096172
50DYRK1B0.83882199
51NLK0.82928761
52PDK10.82291990
53TAOK30.79270715
54IKBKB0.76488882
55PRKCI0.68844407
56ADRBK10.66932514
57MAPKAPK30.65986295
58PASK0.65271991
59FER0.65116821
60PLK40.64557521
61TNK20.64476094
62TIE10.64231563
63NTRK30.63689899
64NUAK10.61035113
65PINK10.60773467
66DYRK30.60363681
67LMTK20.56538338
68CHEK10.55608567
69CHEK20.54593716
70RIPK40.54378780
71WEE10.53227883
72ATR0.53206366
73CDK190.52649385
74KDR0.52330383
75MAP3K120.51503740
76ITK0.50030062
77CAMK2D0.48801002
78GRK10.48490566
79LIMK10.47911591
80EPHA40.45774487
81CAMK1G0.45512714
82CSNK1A1L0.44319807
83STK160.44113921
84KSR10.43922900
85CSNK1A10.42967776
86BRAF0.42953950
87CDK120.42403930
88NME10.41716139
89ERBB30.40493495
90PLK10.40382853
91BRSK20.40005162
92MARK20.38917915
93GRK70.38894890
94ZAP700.38250914
95ATM0.37505779
96MAP3K90.37416311
97PIM10.34948799
98MUSK0.34778497
99MAP3K40.34744212
100OBSCN0.33503744
101PRKCG0.33412105
102NTRK20.33298456
103SGK20.32969928
104PRKCA0.31914455
105STK38L0.31808968
106IGF1R0.31635967
107CDK30.31455394
108CAMKK10.31074799
109SYK0.30667028
110MAP2K70.27152125
111MAP2K60.24393707
112PDPK10.23439959
113PAK60.22996695
114YES10.22675594
115NEK60.22608988
116AKT30.21609136
117MAP3K130.19963713
118PRKAA10.18943148
119EEF2K0.18938419
120EIF2AK30.18125890
121MTOR0.17683663
122PAK10.16785205
123STK110.14873604
124PAK20.14512950
125PRKG10.14335103
126WNK30.14242752
127IRAK20.13162780
128MAPKAPK50.11185724
129PRKCQ0.10411559
130MAP3K60.09689650
131RPS6KB10.08998823
132PRKACB0.08660999
133CSNK1D0.08485807
134PRKDC0.07076346
135CAMK2A0.06970618
136PLK20.06592898
137MAPK80.05689497
138MARK30.05632616
139GSK3B0.05043703
140SIK20.03553089
141PRKACG0.02929331
142CDK10.02912353
143PRKCZ0.02864969
144PDGFRB0.02682711
145EIF2AK20.02197017
146PRKAA20.01971669
147PRKCB0.01330808
148CDK20.00884987
149MAP3K50.00453311
150RPS6KA30.00272097
151CDK150.00254639
152CSNK2A10.00049921
153INSR-7.3908893
154CSNK2A2-0.0219623
155CAMK1-0.0140714
156CDK11A-0.0103298
157PRKACA-0.0020476
158MKNK2-0.0003688

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.23298774
2Pyruvate metabolism_Homo sapiens_hsa006203.89852768
3Dorso-ventral axis formation_Homo sapiens_hsa043203.71926776
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.64183281
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.58926154
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.38271842
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.05984793
8Propanoate metabolism_Homo sapiens_hsa006403.01712909
9Fanconi anemia pathway_Homo sapiens_hsa034602.96489188
10Glucagon signaling pathway_Homo sapiens_hsa049222.89919489
11Butanoate metabolism_Homo sapiens_hsa006502.88159843
12Basal transcription factors_Homo sapiens_hsa030222.78441047
13Fatty acid biosynthesis_Homo sapiens_hsa000612.64905773
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34667880
15Oocyte meiosis_Homo sapiens_hsa041142.28113656
16Pentose phosphate pathway_Homo sapiens_hsa000302.27157929
17Huntingtons disease_Homo sapiens_hsa050162.26969950
18Selenocompound metabolism_Homo sapiens_hsa004502.24683391
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24660052
20Amphetamine addiction_Homo sapiens_hsa050312.18410403
21Linoleic acid metabolism_Homo sapiens_hsa005912.16247730
22Nitrogen metabolism_Homo sapiens_hsa009102.10180653
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.09740080
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84674350
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.76629751
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.75297435
27Protein export_Homo sapiens_hsa030601.74945409
28Renin secretion_Homo sapiens_hsa049241.72261979
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66374080
30Glycerolipid metabolism_Homo sapiens_hsa005611.59493429
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.58929134
32Regulation of autophagy_Homo sapiens_hsa041401.58118145
33Oxidative phosphorylation_Homo sapiens_hsa001901.54751336
34Tryptophan metabolism_Homo sapiens_hsa003801.54130629
35Long-term potentiation_Homo sapiens_hsa047201.50960537
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.48188334
37Peroxisome_Homo sapiens_hsa041461.47668962
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41276717
39Circadian rhythm_Homo sapiens_hsa047101.40150304
40mRNA surveillance pathway_Homo sapiens_hsa030151.37911330
41Cardiac muscle contraction_Homo sapiens_hsa042601.37531075
42beta-Alanine metabolism_Homo sapiens_hsa004101.33371441
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.32706604
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30127771
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27447876
46PPAR signaling pathway_Homo sapiens_hsa033201.22756099
47Sulfur metabolism_Homo sapiens_hsa009201.22712278
48Retinol metabolism_Homo sapiens_hsa008301.21415171
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21105227
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.18481317
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15213802
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14918186
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14401428
54RNA transport_Homo sapiens_hsa030131.11049060
55Calcium signaling pathway_Homo sapiens_hsa040201.09864516
56Caffeine metabolism_Homo sapiens_hsa002321.08805851
57Parkinsons disease_Homo sapiens_hsa050121.08134513
58ABC transporters_Homo sapiens_hsa020101.07560082
59Glycerophospholipid metabolism_Homo sapiens_hsa005641.07326570
60Type I diabetes mellitus_Homo sapiens_hsa049401.06878683
61Purine metabolism_Homo sapiens_hsa002301.02006284
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00740989
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96067382
64Histidine metabolism_Homo sapiens_hsa003400.95691238
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93774974
66Circadian entrainment_Homo sapiens_hsa047130.92988698
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92547192
68Estrogen signaling pathway_Homo sapiens_hsa049150.92453527
69Carbon metabolism_Homo sapiens_hsa012000.91513351
70Serotonergic synapse_Homo sapiens_hsa047260.90461179
71GABAergic synapse_Homo sapiens_hsa047270.87972331
72Glutamatergic synapse_Homo sapiens_hsa047240.86061256
73Folate biosynthesis_Homo sapiens_hsa007900.86032663
74Ether lipid metabolism_Homo sapiens_hsa005650.86031062
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85275026
76Antigen processing and presentation_Homo sapiens_hsa046120.84780560
77Ovarian steroidogenesis_Homo sapiens_hsa049130.83007141
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81304024
79Taste transduction_Homo sapiens_hsa047420.79300294
80Collecting duct acid secretion_Homo sapiens_hsa049660.79028511
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78041862
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74965452
83Primary immunodeficiency_Homo sapiens_hsa053400.73416678
84VEGF signaling pathway_Homo sapiens_hsa043700.72328572
85Fructose and mannose metabolism_Homo sapiens_hsa000510.70714299
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70545640
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70514085
88Synaptic vesicle cycle_Homo sapiens_hsa047210.69357381
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67929069
90Biosynthesis of amino acids_Homo sapiens_hsa012300.67108033
91Mineral absorption_Homo sapiens_hsa049780.65934765
92Nicotine addiction_Homo sapiens_hsa050330.64120215
93Inositol phosphate metabolism_Homo sapiens_hsa005620.62115445
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61482004
95Oxytocin signaling pathway_Homo sapiens_hsa049210.61026420
96Morphine addiction_Homo sapiens_hsa050320.59435178
97Fat digestion and absorption_Homo sapiens_hsa049750.57604257
98Insulin secretion_Homo sapiens_hsa049110.57455407
99Vitamin digestion and absorption_Homo sapiens_hsa049770.56745050
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55015708
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54105911
102Fatty acid metabolism_Homo sapiens_hsa012120.53583112
103N-Glycan biosynthesis_Homo sapiens_hsa005100.51233847
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47709593
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.47380510
106Homologous recombination_Homo sapiens_hsa034400.46743963
107Dopaminergic synapse_Homo sapiens_hsa047280.45898808
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45627200
109cAMP signaling pathway_Homo sapiens_hsa040240.44284627
110Nucleotide excision repair_Homo sapiens_hsa034200.44007222
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.43654462
112B cell receptor signaling pathway_Homo sapiens_hsa046620.42290505
113Fatty acid degradation_Homo sapiens_hsa000710.42007723
114Salivary secretion_Homo sapiens_hsa049700.40479292
115Gastric acid secretion_Homo sapiens_hsa049710.38471273
116Arachidonic acid metabolism_Homo sapiens_hsa005900.38207077
117Phototransduction_Homo sapiens_hsa047440.37901350
118Rheumatoid arthritis_Homo sapiens_hsa053230.37393759
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35639814
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35547096
121Chemical carcinogenesis_Homo sapiens_hsa052040.35539227
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35476230
123Alzheimers disease_Homo sapiens_hsa050100.35340013
124Fatty acid elongation_Homo sapiens_hsa000620.34955856
125Proteasome_Homo sapiens_hsa030500.33679562
126Salmonella infection_Homo sapiens_hsa051320.33454767
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33301823
128AMPK signaling pathway_Homo sapiens_hsa041520.32193693
129Arginine and proline metabolism_Homo sapiens_hsa003300.31901057
130Olfactory transduction_Homo sapiens_hsa047400.31566100
131Thyroid hormone synthesis_Homo sapiens_hsa049180.31171248
132Glutathione metabolism_Homo sapiens_hsa004800.30992674
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30542378
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29950613
135Endocytosis_Homo sapiens_hsa041440.29736819
136Wnt signaling pathway_Homo sapiens_hsa043100.27634415
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27069510
138RNA degradation_Homo sapiens_hsa030180.26514063
139Cocaine addiction_Homo sapiens_hsa050300.26477042
140Metabolic pathways_Homo sapiens_hsa011000.26442670
141Sphingolipid metabolism_Homo sapiens_hsa006000.26368638
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.26102150
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22362988
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.22304045
145Legionellosis_Homo sapiens_hsa051340.21737603
146Bile secretion_Homo sapiens_hsa049760.20301507
147Type II diabetes mellitus_Homo sapiens_hsa049300.19730017
148Pancreatic secretion_Homo sapiens_hsa049720.19521584
149Osteoclast differentiation_Homo sapiens_hsa043800.18913564

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