GDPD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.42624728
2low-density lipoprotein particle clearance (GO:0034383)3.82395475
3regulation of ARF GTPase activity (GO:0032312)3.74461003
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69802162
5central nervous system myelination (GO:0022010)3.65027123
6axon ensheathment in central nervous system (GO:0032291)3.65027123
7mannose metabolic process (GO:0006013)3.54846926
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39743737
9negative regulation of cell killing (GO:0031342)3.39743737
10cell-cell junction maintenance (GO:0045217)3.38630322
11eye photoreceptor cell differentiation (GO:0001754)3.35491129
12photoreceptor cell differentiation (GO:0046530)3.35491129
13positive regulation of gamma-delta T cell activation (GO:0046645)3.30395191
14neuron recognition (GO:0008038)3.23981424
15thymic T cell selection (GO:0045061)3.21735460
16regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17711473
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16468407
18neuron cell-cell adhesion (GO:0007158)3.16430559
19basement membrane organization (GO:0071711)3.16223175
20negative regulation of protein localization to cell surface (GO:2000009)3.15700135
21positive regulation of Rap GTPase activity (GO:0032854)3.14449036
22positive thymic T cell selection (GO:0045059)3.14384407
23morphogenesis of an endothelium (GO:0003159)3.13471050
24endothelial tube morphogenesis (GO:0061154)3.13471050
25modulation by virus of host process (GO:0019054)3.11293103
26positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.10694625
27positive regulation of histone deacetylation (GO:0031065)3.10065874
28protein localization to synapse (GO:0035418)3.07784134
29regulation of rhodopsin mediated signaling pathway (GO:0022400)3.07645212
30angiogenesis involved in wound healing (GO:0060055)3.06131373
31negative regulation of granulocyte differentiation (GO:0030853)3.05135259
32rhodopsin mediated signaling pathway (GO:0016056)2.99895977
33dendritic spine morphogenesis (GO:0060997)2.96015248
34photoreceptor cell maintenance (GO:0045494)2.93530085
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93323481
36vocalization behavior (GO:0071625)2.92798031
37axonal fasciculation (GO:0007413)2.91717115
38antigen processing and presentation of endogenous antigen (GO:0019883)2.90438169
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89871322
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88917183
41cell volume homeostasis (GO:0006884)2.88916042
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88314680
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87480565
44regulation of gamma-delta T cell differentiation (GO:0045586)2.86748946
45positive regulation of CREB transcription factor activity (GO:0032793)2.85583749
46regulation of response to osmotic stress (GO:0047484)2.85145314
47tolerance induction (GO:0002507)2.83827506
48blood vessel maturation (GO:0001955)2.81867423
49modulation by symbiont of host cellular process (GO:0044068)2.80932861
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80501924
51regulation of ARF protein signal transduction (GO:0032012)2.80470737
52regulation of extracellular matrix disassembly (GO:0010715)2.78053776
53regulation of voltage-gated calcium channel activity (GO:1901385)2.78016172
54negative thymic T cell selection (GO:0045060)2.77253755
55semaphorin-plexin signaling pathway (GO:0071526)2.77176564
56T cell selection (GO:0045058)2.75728974
57diacylglycerol metabolic process (GO:0046339)2.75640000
58cerebral cortex radially oriented cell migration (GO:0021799)2.73829113
59lymph vessel development (GO:0001945)2.72990561
60positive regulation of receptor recycling (GO:0001921)2.72706960
61regulation of gamma-delta T cell activation (GO:0046643)2.72376992
62ionotropic glutamate receptor signaling pathway (GO:0035235)2.72159795
63negative T cell selection (GO:0043383)2.71322383
64regulation of glycogen (starch) synthase activity (GO:2000465)2.71319757
65phosphatidylethanolamine biosynthetic process (GO:0006646)2.67906511
66positive T cell selection (GO:0043368)2.67526709
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67525198
68cell junction maintenance (GO:0034331)2.66224029
69vascular endothelial growth factor signaling pathway (GO:0038084)2.63214217
70endothelium development (GO:0003158)2.62274844
71auditory behavior (GO:0031223)2.62154465
72cellular potassium ion homeostasis (GO:0030007)2.61336651
73protein targeting to plasma membrane (GO:0072661)2.60756353
74glutamate receptor signaling pathway (GO:0007215)2.60476260
75synaptic vesicle exocytosis (GO:0016079)2.59910546
76synaptic vesicle maturation (GO:0016188)2.58758872
77response to auditory stimulus (GO:0010996)2.58601039
78regulation of synaptic vesicle exocytosis (GO:2000300)2.58489385
79neuronal action potential propagation (GO:0019227)2.58428487
80regulation of Rap GTPase activity (GO:0032317)2.57983530
81presynaptic membrane organization (GO:0097090)2.57871895
82cell migration in hindbrain (GO:0021535)2.57749055
83positive regulation of extracellular matrix organization (GO:1903055)2.57325127
84synaptic transmission, glutamatergic (GO:0035249)2.56392454
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56211743
86adult walking behavior (GO:0007628)2.56108370
87histone H4 deacetylation (GO:0070933)2.55580170
88layer formation in cerebral cortex (GO:0021819)2.55396905
89negative regulation of blood vessel endothelial cell migration (GO:0043537)2.52990481
90response to interleukin-15 (GO:0070672)2.52920442
91cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.52819730
92presynaptic membrane assembly (GO:0097105)2.52593553
93regulation of histone H3-K27 methylation (GO:0061085)2.52096128
94response to laminar fluid shear stress (GO:0034616)2.51840401
95dendrite morphogenesis (GO:0048813)2.51824255
96limb bud formation (GO:0060174)2.49227632
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48502156
98positive regulation of potassium ion transmembrane transport (GO:1901381)2.48373276
99vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.48061583
100long-chain fatty acid biosynthetic process (GO:0042759)2.47944627
101postsynaptic membrane organization (GO:0001941)2.47074358
102signal complex assembly (GO:0007172)2.46951516
103transmission of nerve impulse (GO:0019226)2.46708385
104membrane hyperpolarization (GO:0060081)2.46420393
105positive regulation of synapse assembly (GO:0051965)2.46387498
106insulin-like growth factor receptor signaling pathway (GO:0048009)2.45149240
107neuron-neuron synaptic transmission (GO:0007270)2.44631039
108neuronal action potential (GO:0019228)2.44089013
109stress fiber assembly (GO:0043149)2.44060972
110histone H3 deacetylation (GO:0070932)2.43930258
111potassium ion homeostasis (GO:0055075)2.43869478
112glutamate secretion (GO:0014047)2.42577018
113positive regulation of synapse maturation (GO:0090129)2.42526274
114activation of JUN kinase activity (GO:0007257)2.42463718
115regulation of synapse structural plasticity (GO:0051823)2.42334610
116negative regulation of cAMP-mediated signaling (GO:0043951)2.41970814
117regulation of cholesterol homeostasis (GO:2000188)2.41737749
118negative regulation of synaptic transmission, GABAergic (GO:0032229)2.41585138
119protein kinase C signaling (GO:0070528)2.40708018
120regulation of T cell tolerance induction (GO:0002664)2.40435300
121regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.40039087
122detection of light stimulus involved in sensory perception (GO:0050962)2.39739354
123detection of light stimulus involved in visual perception (GO:0050908)2.39739354
124protein carboxylation (GO:0018214)2.38817460
125peptidyl-glutamic acid carboxylation (GO:0017187)2.38817460
126negative regulation of fatty acid transport (GO:2000192)2.38733019
127regulation of membrane repolarization (GO:0060306)2.38423094
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.37820681
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.37820681
130modulation by symbiont of host immune response (GO:0052553)2.37820681
131positive regulation by symbiont of host defense response (GO:0052509)2.37820681
132modulation by symbiont of host defense response (GO:0052031)2.37820681
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.37820681
134regulation of glutamate receptor signaling pathway (GO:1900449)2.37454597
135negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.37324910
136negative regulation of axon guidance (GO:1902668)2.36604509
137phosphatidylethanolamine metabolic process (GO:0046337)2.35721790
138positive regulation of protein deacetylation (GO:0090312)2.34234778
139phospholipid scrambling (GO:0017121)2.33809934
140leukocyte aggregation (GO:0070486)2.33305125
141hyaluronan catabolic process (GO:0030214)2.31216747
142synapse assembly (GO:0007416)2.29310618
143modulation by virus of host morphology or physiology (GO:0019048)2.28954651
144response to muramyl dipeptide (GO:0032495)2.28291463
145regulation of neuronal synaptic plasticity (GO:0048168)2.28101196
146neuronal ion channel clustering (GO:0045161)2.28065094
147positive regulation of protein kinase C signaling (GO:0090037)2.27488893
148peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.27339972
149regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.27037500
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.25204587
151positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.25174296
152regulation of synapse assembly (GO:0051963)2.25047322
153multicellular organismal signaling (GO:0035637)2.24915958
154regulation of long-term neuronal synaptic plasticity (GO:0048169)2.24854784
155locomotory exploration behavior (GO:0035641)2.24580014
156regulation of T-helper 2 cell differentiation (GO:0045628)2.24192361
157neurofilament cytoskeleton organization (GO:0060052)2.23806322
158actin filament capping (GO:0051693)2.23303011
159regulation of early endosome to late endosome transport (GO:2000641)2.23037562
160central nervous system projection neuron axonogenesis (GO:0021952)2.22983809
161regulation of synapse maturation (GO:0090128)2.22750160
162regulation of excitatory postsynaptic membrane potential (GO:0060079)2.22445697
163cortical cytoskeleton organization (GO:0030865)2.22323969
164regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.21380650
165regulation of postsynaptic membrane potential (GO:0060078)2.21268444
166peptidyl-tyrosine autophosphorylation (GO:0038083)2.21131857
167negative regulation of axon extension involved in axon guidance (GO:0048843)2.20981756
168hypotonic response (GO:0006971)2.20632218
169glycine transport (GO:0015816)2.20403138
170membrane depolarization during action potential (GO:0086010)2.20341360
171melanin metabolic process (GO:0006582)2.20237396
172histone H3-K4 trimethylation (GO:0080182)2.20221568
173retina layer formation (GO:0010842)2.20170121
174plasma membrane fusion (GO:0045026)2.19212159
175regulation of synaptic vesicle transport (GO:1902803)2.19121810
176cell communication involved in cardiac conduction (GO:0086065)2.19081408
177adult locomotory behavior (GO:0008344)2.18884979
178germinal center formation (GO:0002467)2.18658436
179melanin biosynthetic process (GO:0042438)2.18447774
180myelination (GO:0042552)2.18387525
181synaptic vesicle endocytosis (GO:0048488)2.17393957
182regulation of heart rate by cardiac conduction (GO:0086091)2.17249581
183negative regulation of endothelial cell migration (GO:0010596)2.17138949
184neurotransmitter-gated ion channel clustering (GO:0072578)2.16911695
185mechanosensory behavior (GO:0007638)2.16500910
186positive regulation of action potential (GO:0045760)2.16364055
187membrane repolarization (GO:0086009)2.16271276
188axon ensheathment (GO:0008366)2.15885039
189ensheathment of neurons (GO:0007272)2.15885039
190regulation of neurotransmitter secretion (GO:0046928)2.15592199
191cerebellar Purkinje cell differentiation (GO:0021702)2.14886344
192positive regulation of potassium ion transport (GO:0043268)2.14859147
193righting reflex (GO:0060013)2.14604609
194regulation of axon guidance (GO:1902667)2.14582679
195startle response (GO:0001964)2.13392449
196positive regulation of synaptic transmission, GABAergic (GO:0032230)2.11666003
197response to pheromone (GO:0019236)2.11467789
198regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.11425728
199apical protein localization (GO:0045176)2.11381140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.62728918
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.38322665
3* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.99685201
4GBX2_23144817_ChIP-Seq_PC3_Human2.91897483
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82724906
6LXR_22292898_ChIP-Seq_THP-1_Human2.82273576
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75845430
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75194313
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66304020
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66304020
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.64447333
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56141286
13KDM2B_26808549_Chip-Seq_DND41_Human2.51381913
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49522890
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.49022419
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.43740293
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42615105
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42456918
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.41005096
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.37076494
21* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35016463
22TCF7_22412390_ChIP-Seq_EML_Mouse2.34081838
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28712602
24MYC_22102868_ChIP-Seq_BL_Human2.27851657
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.24375118
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23184648
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23131296
28VDR_21846776_ChIP-Seq_THP-1_Human2.13856893
29DROSHA_22980978_ChIP-Seq_HELA_Human2.08471942
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89808411
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89461161
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89014252
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87499013
34P68_20966046_ChIP-Seq_HELA_Human1.86520491
35AR_21572438_ChIP-Seq_LNCaP_Human1.86051132
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84348484
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83588661
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.83267887
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.82019487
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.81939351
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79748512
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78794390
43SMC4_20622854_ChIP-Seq_HELA_Human1.74710269
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.72618079
45GATA1_19941826_ChIP-Seq_K562_Human1.72502563
46RUNX_20019798_ChIP-Seq_JUKART_Human1.68599636
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67688864
48RACK7_27058665_Chip-Seq_MCF-7_Human1.65265670
49* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.63611629
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62359542
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61569208
52* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60713858
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60304211
54* MAF_26560356_Chip-Seq_TH1_Human1.60227894
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60199156
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58807275
57* SA1_27219007_Chip-Seq_ERYTHROID_Human1.58606539
58CTCF_27219007_Chip-Seq_Bcells_Human1.58489648
59UTX_26944678_Chip-Seq_JUKART_Human1.57452051
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.56890730
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53236725
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52335138
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52127579
64TAF15_26573619_Chip-Seq_HEK293_Human1.51248498
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.51153226
66MAF_26560356_Chip-Seq_TH2_Human1.50885643
67REST_21632747_ChIP-Seq_MESCs_Mouse1.49635087
68BCL6_27268052_Chip-Seq_Bcells_Human1.49541799
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47941141
70BCOR_27268052_Chip-Seq_Bcells_Human1.46324898
71* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46223081
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46029055
73AHR_22903824_ChIP-Seq_MCF-7_Human1.44050710
74SPI1_23127762_ChIP-Seq_K562_Human1.43539554
75* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43456428
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41990340
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41966668
78VDR_24763502_ChIP-Seq_THP-1_Human1.41719199
79* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40645647
80SCL_19346495_ChIP-Seq_HPC-7_Human1.39165365
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.37991148
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.37937310
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.36680426
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.36410386
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35384046
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.34353364
87SMAD4_21799915_ChIP-Seq_A2780_Human1.33287614
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.33116663
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32010426
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.31773307
91TP53_22127205_ChIP-Seq_IMR90_Human1.31545304
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31105820
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30111089
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.29963076
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29704363
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.28737147
97RNF2_27304074_Chip-Seq_NSC_Mouse1.28617239
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28074284
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27531633
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27002292
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25196496
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24616955
103P300_19829295_ChIP-Seq_ESCs_Human1.24341936
104PHF8_20622854_ChIP-Seq_HELA_Human1.23151174
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22647172
106OCT4_19829295_ChIP-Seq_ESCs_Human1.22454178
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22152393
108CREB1_26743006_Chip-Seq_LNCaP_Human1.22032482
109TET1_21451524_ChIP-Seq_MESCs_Mouse1.22013272
110* RARB_27405468_Chip-Seq_BRAIN_Mouse1.21326163
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20082355
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.20032868
113CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19691222
114VDR_22108803_ChIP-Seq_LS180_Human1.19335056
115E2F1_20622854_ChIP-Seq_HELA_Human1.19201478
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19063213
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.18858178
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18020183
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17657791
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17469835
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15983020
122FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15718026
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15127947
124NCOR1_26117541_ChIP-Seq_K562_Human1.15078266
125* TP63_22573176_ChIP-Seq_HFKS_Human1.14934483
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14683762
127SMAD_19615063_ChIP-ChIP_OVARY_Human1.14532416
128WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13700480
129PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13461488
130* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13392524
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12772943
132SA1_27219007_Chip-Seq_Bcells_Human1.12629035
133REST_18959480_ChIP-ChIP_MESCs_Mouse1.11963808
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11857742
135TP53_20018659_ChIP-ChIP_R1E_Mouse1.11524291
136BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11177299
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09866323
138RUNX1_27514584_Chip-Seq_MCF-7_Human1.09852405
139* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09733298
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08620878
141P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07999085
142NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07517710
143SMAD3_21741376_ChIP-Seq_HESCs_Human1.07469414
144P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06186127
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05877230
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04839995
147* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04761132
148SMAD4_21741376_ChIP-Seq_HESCs_Human1.04052526
149STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03181294
150TP53_18474530_ChIP-ChIP_U2OS_Human1.02007971
151SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01893509
152TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01796086
153IGF1R_20145208_ChIP-Seq_DFB_Human1.01638516
154KLF4_19829295_ChIP-Seq_ESCs_Human1.01593362
155* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00368654
156* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99914742
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99880699
158* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99468036
159POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99220507
160ESR1_20079471_ChIP-ChIP_T-47D_Human0.99068599
161* TP53_23651856_ChIP-Seq_MEFs_Mouse0.98812878
162ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98636808
163GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98084837
164NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97762358
165TET1_21490601_ChIP-Seq_MESCs_Mouse0.97439583
166POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97224204
167TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97224204
168MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97189227
169PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96893441
170STAT3_23295773_ChIP-Seq_U87_Human0.96373881
171NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96240777
172CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95959289
173ER_23166858_ChIP-Seq_MCF-7_Human0.95683394
174RXR_22158963_ChIP-Seq_LIVER_Mouse0.95245021
175CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95241941
176PRDM14_20953172_ChIP-Seq_ESCs_Human0.95232756
177YY1_22570637_ChIP-Seq_MALME-3M_Human0.94711731
178PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94151643
179TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93423770
180AR_25329375_ChIP-Seq_VCAP_Human0.92567719
181KDM2B_26808549_Chip-Seq_K562_Human0.92342256
182* SOX2_21211035_ChIP-Seq_LN229_Gbm0.92273149
183UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91833204
184NANOG_18555785_Chip-Seq_ESCs_Mouse0.90057412
185MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89658291
186AR_19668381_ChIP-Seq_PC3_Human0.89505522
187WT1_19549856_ChIP-ChIP_CCG9911_Human0.88932379
188TCF4_23295773_ChIP-Seq_U87_Human0.88648817
189LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87977453
190RUNX2_22187159_ChIP-Seq_PCA_Human0.86909115
191* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86313359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.48379027
2MP0003880_abnormal_central_pattern3.32497036
3MP0010368_abnormal_lymphatic_system3.29137619
4MP0003172_abnormal_lysosome_physiology3.21916466
5MP0004859_abnormal_synaptic_plasticity3.14778900
6MP0002933_joint_inflammation2.73207848
7MP0005551_abnormal_eye_electrophysiolog2.70501743
8MP0003436_decreased_susceptibility_to2.55546500
9MP0004270_analgesia2.47687380
10MP0005167_abnormal_blood-brain_barrier2.45176767
11MP0003635_abnormal_synaptic_transmissio2.37778623
12MP0005377_hearing/vestibular/ear_phenot2.36990787
13MP0003878_abnormal_ear_physiology2.36990787
14MP0004130_abnormal_muscle_cell2.31845263
15MP0001486_abnormal_startle_reflex2.31360186
16MP0000778_abnormal_nervous_system2.31141454
17MP0001984_abnormal_olfaction2.27979969
18MP0005423_abnormal_somatic_nervous2.26529304
19MP0001968_abnormal_touch/_nociception2.22071401
20MP0002735_abnormal_chemical_nociception2.19652731
21MP0003724_increased_susceptibility_to2.15886812
22MP0009745_abnormal_behavioral_response2.08845902
23MP0005058_abnormal_lysosome_morphology2.08332292
24MP0002734_abnormal_mechanical_nocicepti2.07959402
25MP0002272_abnormal_nervous_system2.07428107
26MP0002063_abnormal_learning/memory/cond2.01655104
27MP0005623_abnormal_meninges_morphology2.00314438
28MP0002064_seizures1.99552541
29MP0009278_abnormal_bone_marrow1.99393851
30MP0003279_aneurysm1.96816143
31MP0005666_abnormal_adipose_tissue1.95569449
32MP0009046_muscle_twitch1.93382375
33MP0005083_abnormal_biliary_tract1.88330143
34MP0003705_abnormal_hypodermis_morpholog1.87548487
35MP0003303_peritoneal_inflammation1.84813645
36MP0005375_adipose_tissue_phenotype1.80738330
37MP0001849_ear_inflammation1.80679909
38MP0003828_pulmonary_edema1.78236812
39MP0002736_abnormal_nociception_after1.78173611
40MP0002184_abnormal_innervation1.77853538
41MP0002572_abnormal_emotion/affect_behav1.76763018
42MP0004742_abnormal_vestibular_system1.75787056
43MP0004381_abnormal_hair_follicle1.73705793
44MP0009115_abnormal_fat_cell1.73581870
45MP0000920_abnormal_myelination1.71426128
46MP0001879_abnormal_lymphatic_vessel1.71231412
47MP0001348_abnormal_lacrimal_gland1.69164310
48MP0006072_abnormal_retinal_apoptosis1.68525350
49MP0005253_abnormal_eye_physiology1.65955207
50MP0002067_abnormal_sensory_capabilities1.63972914
51MP0001970_abnormal_pain_threshold1.61157010
52MP0006138_congestive_heart_failure1.60087812
53MP0003950_abnormal_plasma_membrane1.59370539
54MP0002882_abnormal_neuron_morphology1.58547640
55MP0003763_abnormal_thymus_physiology1.56889796
56MP0004885_abnormal_endolymph1.56633410
57MP0003300_gastrointestinal_ulcer1.56350379
58MP0000767_abnormal_smooth_muscle1.55944047
59MP0005409_darkened_coat_color1.53236495
60MP0000569_abnormal_digit_pigmentation1.53091008
61MP0002752_abnormal_somatic_nervous1.52244056
62MP0004858_abnormal_nervous_system1.52205178
63MP0002733_abnormal_thermal_nociception1.51151375
64MP0006276_abnormal_autonomic_nervous1.48874088
65MP0000003_abnormal_adipose_tissue1.47721077
66MP0001188_hyperpigmentation1.46485536
67MP0002557_abnormal_social/conspecific_i1.45747599
68MP0002132_abnormal_respiratory_system1.45709880
69MP0000685_abnormal_immune_system1.43332597
70MP0001502_abnormal_circadian_rhythm1.42558608
71MP0008789_abnormal_olfactory_epithelium1.40932559
72MP0001790_abnormal_immune_system1.39724613
73MP0005387_immune_system_phenotype1.39724613
74MP0005195_abnormal_posterior_eye1.38975054
75MP0001485_abnormal_pinna_reflex1.33895896
76MP0010329_abnormal_lipoprotein_level1.33193601
77MP0001440_abnormal_grooming_behavior1.32398954
78MP0000955_abnormal_spinal_cord1.32247335
79MP0002971_abnormal_brown_adipose1.31657309
80MP0000015_abnormal_ear_pigmentation1.30642970
81MP0005076_abnormal_cell_differentiation1.29657096
82MP0005410_abnormal_fertilization1.29389262
83MP0004272_abnormal_basement_membrane1.29155784
84MP0000751_myopathy1.28829537
85MP0005451_abnormal_body_composition1.28704437
86MP0008569_lethality_at_weaning1.28610433
87MP0005499_abnormal_olfactory_system1.27722028
88MP0005394_taste/olfaction_phenotype1.27722028
89MP0000566_synostosis1.27507975
90MP0002138_abnormal_hepatobiliary_system1.27253070
91MP0004924_abnormal_behavior1.26961425
92MP0005386_behavior/neurological_phenoty1.26961425
93MP0003011_delayed_dark_adaptation1.26790436
94MP0002229_neurodegeneration1.26735194
95MP0000465_gastrointestinal_hemorrhage1.26627641
96MP0003091_abnormal_cell_migration1.25081672
97MP0001800_abnormal_humoral_immune1.23814429
98MP0002822_catalepsy1.23526168
99MP0002419_abnormal_innate_immunity1.23231095
100MP0008438_abnormal_cutaneous_collagen1.23066927
101MP0003634_abnormal_glial_cell1.22921719
102MP0005171_absent_coat_pigmentation1.22420921
103MP0001963_abnormal_hearing_physiology1.21944215
104MP0005464_abnormal_platelet_physiology1.21516814
105MP0005646_abnormal_pituitary_gland1.21269352
106MP0002970_abnormal_white_adipose1.20940845
107MP0000026_abnormal_inner_ear1.20190192
108MP0003137_abnormal_impulse_conducting1.20039043
109MP0003566_abnormal_cell_adhesion1.18698772
110MP0000249_abnormal_blood_vessel1.18408334
111MP0001905_abnormal_dopamine_level1.17664468
112MP0001533_abnormal_skeleton_physiology1.17409409
113MP0001915_intracranial_hemorrhage1.16571945
114MP0002405_respiratory_system_inflammati1.15409140
115MP0005025_abnormal_response_to1.14911826
116MP0004145_abnormal_muscle_electrophysio1.13653430
117MP0002998_abnormal_bone_remodeling1.09569671
118MP0004085_abnormal_heartbeat1.09311837
119MP0004185_abnormal_adipocyte_glucose1.08928926
120MP0001958_emphysema1.08637938
121MP0005645_abnormal_hypothalamus_physiol1.08168388
122MP0005000_abnormal_immune_tolerance1.07165432
123MP0001501_abnormal_sleep_pattern1.06532786
124MP0002102_abnormal_ear_morphology1.06392420
125MP0001346_abnormal_lacrimal_gland1.05816378
126MP0002420_abnormal_adaptive_immunity1.05552527
127MP0004142_abnormal_muscle_tone1.05249274
128MP0000013_abnormal_adipose_tissue1.04988498
129MP0002090_abnormal_vision1.04944547
130MP0002723_abnormal_immune_serum1.04871817
131MP0004811_abnormal_neuron_physiology1.04178969
132MP0001545_abnormal_hematopoietic_system1.03399895
133MP0005397_hematopoietic_system_phenotyp1.03399895
134MP0001819_abnormal_immune_cell1.03066027
135MP0001529_abnormal_vocalization1.02533864
136MP0002066_abnormal_motor_capabilities/c1.01927980
137MP0001851_eye_inflammation0.99705728
138MP0009333_abnormal_splenocyte_physiolog0.98094451
139MP0005360_urolithiasis0.95549986
140MP0003385_abnormal_body_wall0.95534357
141MP0002277_abnormal_respiratory_mucosa0.95141428
142MP0010386_abnormal_urinary_bladder0.94792080
143MP0002398_abnormal_bone_marrow0.94323278
144MP0002152_abnormal_brain_morphology0.91311918
145MP0001299_abnormal_eye_distance/0.91285969
146MP0002452_abnormal_antigen_presenting0.91022516
147MP0004215_abnormal_myocardial_fiber0.90977419
148MP0003329_amyloid_beta_deposits0.90602609
149MP0002972_abnormal_cardiac_muscle0.89973693
150MP0002249_abnormal_larynx_morphology0.89738465
151MP0003690_abnormal_glial_cell0.89500927
152MP0000762_abnormal_tongue_morphology0.89157698
153MP0000858_altered_metastatic_potential0.89033341
154MP0009780_abnormal_chondrocyte_physiolo0.88152369
155MP0004947_skin_inflammation0.87087594
156MP0004084_abnormal_cardiac_muscle0.86933885
157MP0003879_abnormal_hair_cell0.86322403
158MP0010030_abnormal_orbit_morphology0.86178858
159MP0003959_abnormal_lean_body0.85957154
160MP0002638_abnormal_pupillary_reflex0.85608294
161MP0006054_spinal_hemorrhage0.85519828
162MP0008260_abnormal_autophagy0.84780365
163MP0000371_diluted_coat_color0.83767865
164MP0000678_abnormal_parathyroid_gland0.82297252
165MP0000049_abnormal_middle_ear0.82080591
166MP0003122_maternal_imprinting0.81731688
167MP0004036_abnormal_muscle_relaxation0.81549843
168MP0001614_abnormal_blood_vessel0.81050628
169MP0005334_abnormal_fat_pad0.81004760
170MP0001986_abnormal_taste_sensitivity0.79119247
171MP0001873_stomach_inflammation0.78873211
172MP0003631_nervous_system_phenotype0.78615722
173MP0005448_abnormal_energy_balance0.78560272
174MP0000609_abnormal_liver_physiology0.78099095
175MP0000716_abnormal_immune_system0.77668207
176MP0002089_abnormal_postnatal_growth/wei0.77568087
177MP0003633_abnormal_nervous_system0.77385640
178MP0002751_abnormal_autonomic_nervous0.76918507
179MP0003632_abnormal_nervous_system0.76353539
180MP0002925_abnormal_cardiovascular_devel0.76290338
181MP0002295_abnormal_pulmonary_circulatio0.75523603
182MP0009250_abnormal_appendicular_skeleto0.75018356
183MP0001664_abnormal_digestion0.74966787
184MP0000703_abnormal_thymus_morphology0.74775636
185MP0002128_abnormal_blood_circulation0.73381246
186MP0000579_abnormal_nail_morphology0.73090200
187MP0005620_abnormal_muscle_contractility0.72726374
188MP0005408_hypopigmentation0.72038353
189MP0003656_abnormal_erythrocyte_physiolo0.71332918
190MP0003948_abnormal_gas_homeostasis0.70468332

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.60421940
2Obstructive sleep apnea (HP:0002870)4.55362692
3Central scotoma (HP:0000603)3.95831527
4Myokymia (HP:0002411)3.84437561
5Cerebral aneurysm (HP:0004944)3.55801089
6Hemorrhage of the eye (HP:0011885)3.42777238
7Stridor (HP:0010307)3.37450253
8Dyschromatopsia (HP:0007641)3.32973779
9Focal motor seizures (HP:0011153)3.32623919
10Protrusio acetabuli (HP:0003179)3.32342843
11Deep venous thrombosis (HP:0002625)3.30327114
12Increased corneal curvature (HP:0100692)3.23840306
13Keratoconus (HP:0000563)3.23840306
14Upper limb amyotrophy (HP:0009129)3.14538875
15Distal upper limb amyotrophy (HP:0007149)3.14538875
16Bony spicule pigmentary retinopathy (HP:0007737)3.13661390
17Febrile seizures (HP:0002373)3.11254852
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.08533778
19Scotoma (HP:0000575)3.01568475
20Hand muscle atrophy (HP:0009130)3.00903773
21Abnormal rod and cone electroretinograms (HP:0008323)2.99976120
22Limb dystonia (HP:0002451)2.99749986
23Polycythemia (HP:0001901)2.97867493
24Prolonged bleeding time (HP:0003010)2.96953030
25Focal seizures (HP:0007359)2.96441799
26Progressive cerebellar ataxia (HP:0002073)2.87798949
27Broad face (HP:0000283)2.79468580
28Eczematoid dermatitis (HP:0000976)2.78013947
29Decreased central vision (HP:0007663)2.77883899
30Prolonged QT interval (HP:0001657)2.71723747
31Muscle fiber splitting (HP:0003555)2.70519128
32Pustule (HP:0200039)2.69071395
33Epileptic encephalopathy (HP:0200134)2.68936757
34Cervical subluxation (HP:0003308)2.67212127
35Abnormality of macular pigmentation (HP:0008002)2.66891395
36Supranuclear gaze palsy (HP:0000605)2.65308440
37Hypertriglyceridemia (HP:0002155)2.63601985
38Spontaneous hematomas (HP:0007420)2.62735721
39Flat acetabular roof (HP:0003180)2.62676314
40Disproportionate tall stature (HP:0001519)2.57410870
41Colitis (HP:0002583)2.56909005
42Congenital sensorineural hearing impairment (HP:0008527)2.55445657
43Abnormality of the fingertips (HP:0001211)2.51836013
44Easy fatigability (HP:0003388)2.51383616
45Broad-based gait (HP:0002136)2.50405024
46Diaphragmatic weakness (HP:0009113)2.48560930
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.44385102
48Difficulty running (HP:0009046)2.43133679
49Abolished electroretinogram (ERG) (HP:0000550)2.43036808
50Coxa vara (HP:0002812)2.42703048
51Neurofibrillary tangles (HP:0002185)2.41694863
52Action tremor (HP:0002345)2.40839717
53Syncope (HP:0001279)2.40396505
54Ankle clonus (HP:0011448)2.39830181
55Metaphyseal cupping (HP:0003021)2.38582383
56Degeneration of the lateral corticospinal tracts (HP:0002314)2.32737107
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32737107
58Epiphyseal dysplasia (HP:0002656)2.30438030
59Gastrointestinal inflammation (HP:0004386)2.30391620
60Aplasia involving bones of the upper limbs (HP:0009823)2.29799966
61Aplasia of the phalanges of the hand (HP:0009802)2.29799966
62Aplasia involving bones of the extremities (HP:0009825)2.29799966
63Joint hemorrhage (HP:0005261)2.29702567
64Hypochromic anemia (HP:0001931)2.28883393
65Choroideremia (HP:0001139)2.28636584
66Septo-optic dysplasia (HP:0100842)2.28504913
67Distal lower limb muscle weakness (HP:0009053)2.26355846
68Menorrhagia (HP:0000132)2.25092969
69Onion bulb formation (HP:0003383)2.23297692
70Ocular albinism (HP:0001107)2.22685853
71Atrial fibrillation (HP:0005110)2.20973258
72Inflammation of the large intestine (HP:0002037)2.18868622
73Sudden death (HP:0001699)2.18742424
74Abnormality of the corticospinal tract (HP:0002492)2.16523515
75Hypochromic microcytic anemia (HP:0004840)2.15489779
76Nonimmune hydrops fetalis (HP:0001790)2.15261037
77Increased connective tissue (HP:0009025)2.14831421
78Primary atrial arrhythmia (HP:0001692)2.13422021
79Gait imbalance (HP:0002141)2.12837019
80Abnormal vertebral ossification (HP:0100569)2.12773719
81Gastrointestinal infarctions (HP:0005244)2.09996336
82Lymphangioma (HP:0100764)2.08248146
83Synostosis involving the elbow (HP:0003938)2.06211090
84Humeroradial synostosis (HP:0003041)2.06211090
85Mixed hearing impairment (HP:0000410)2.04279337
86Termporal pattern (HP:0011008)2.04203923
87Insidious onset (HP:0003587)2.04203923
88Broad palm (HP:0001169)2.04072097
89Myositis (HP:0100614)2.03873923
90Pigmentary retinal degeneration (HP:0001146)2.03854707
91Asymmetric septal hypertrophy (HP:0001670)2.03508114
92Annular pancreas (HP:0001734)2.01936824
93Abnormal EKG (HP:0003115)2.01934403
94Reticulocytosis (HP:0001923)2.01609005
95Epistaxis (HP:0000421)1.97788887
96Dysostosis multiplex (HP:0000943)1.96922033
97Atonic seizures (HP:0010819)1.96871025
98Gingivitis (HP:0000230)1.96606813
99Aneurysm (HP:0002617)1.95716111
100Attenuation of retinal blood vessels (HP:0007843)1.95645876
101Segmental peripheral demyelination/remyelination (HP:0003481)1.95635756
102Mucopolysacchariduria (HP:0008155)1.94941896
103Urinary glycosaminoglycan excretion (HP:0003541)1.94941896
104Hypoplasia of the iris (HP:0007676)1.94093386
105Supraventricular arrhythmia (HP:0005115)1.93809528
106Abnormal gallbladder physiology (HP:0012438)1.92180040
107Cholecystitis (HP:0001082)1.92180040
108Supraventricular tachycardia (HP:0004755)1.91267807
109Exotropia (HP:0000577)1.91179868
110Thin bony cortex (HP:0002753)1.90932925
111Abnormality of polysaccharide metabolism (HP:0011012)1.90907357
112Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90907357
113Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90907357
114Absent septum pellucidum (HP:0001331)1.90361127
115Thin ribs (HP:0000883)1.90281993
116Vaginal atresia (HP:0000148)1.89566010
117Aortic aneurysm (HP:0004942)1.89501066
118Increased variability in muscle fiber diameter (HP:0003557)1.88798869
119Chorioretinal atrophy (HP:0000533)1.88102873
120Esophageal varix (HP:0002040)1.87948390
121Slow saccadic eye movements (HP:0000514)1.87770020
122Ulnar claw (HP:0001178)1.87542348
123Retinal dysplasia (HP:0007973)1.86998543
124Amblyopia (HP:0000646)1.86416727
125Shallow orbits (HP:0000586)1.86301565
126Genital tract atresia (HP:0001827)1.85615568
127Cellulitis (HP:0100658)1.84671667
128Medial flaring of the eyebrow (HP:0010747)1.83924087
129Spinal muscular atrophy (HP:0007269)1.83758162
130Abnormality of carpal bone ossification (HP:0006257)1.81824185
131J-shaped sella turcica (HP:0002680)1.79802963
132Hematochezia (HP:0002573)1.78234733
133Abnormality of the heme biosynthetic pathway (HP:0010472)1.78212580
134Nephrogenic diabetes insipidus (HP:0009806)1.76975066
135Hip contracture (HP:0003273)1.76805556
136Abnormality of the nasal mucosa (HP:0000433)1.76644134
137Peripheral hypomyelination (HP:0007182)1.76547891
138Abnormality of the peritoneum (HP:0002585)1.75776039
139Specific learning disability (HP:0001328)1.75492400
140Aplasia/Hypoplasia of the lens (HP:0008063)1.75291591
141Vascular tortuosity (HP:0004948)1.74800284
142Scanning speech (HP:0002168)1.74577241
143Hyperlipoproteinemia (HP:0010980)1.74164093
144Lower limb amyotrophy (HP:0007210)1.73500720
145Parakeratosis (HP:0001036)1.73118555
146Myocardial infarction (HP:0001658)1.72538214
147Joint stiffness (HP:0001387)1.72483332
148Abnormality of macrophages (HP:0004311)1.72140573
149Emphysema (HP:0002097)1.71401825
150Abnormal ossification of hand bones (HP:0005921)1.71134378
151Sleep apnea (HP:0010535)1.71069973
152Iris hypopigmentation (HP:0007730)1.71051649
153Generalized tonic-clonic seizures (HP:0002069)1.70672124
154Purpura (HP:0000979)1.70092892
155Peritonitis (HP:0002586)1.69386276
156Dislocated radial head (HP:0003083)1.69104913
157Arterial tortuosity (HP:0005116)1.68907704
158Ulnar deviation of the wrist (HP:0003049)1.68554795
159Xerostomia (HP:0000217)1.68046059
160Abnormality of the acetabulum (HP:0003170)1.67968760
161Hemiparesis (HP:0001269)1.67853403
162Alacrima (HP:0000522)1.67700161
163Congenital primary aphakia (HP:0007707)1.67004364
164Hypercholesterolemia (HP:0003124)1.66548571
165Hypoplasia of the brainstem (HP:0002365)1.65927674
166Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65927674
167Hypoplasia of the odontoid process (HP:0003311)1.65639688
168Orchitis (HP:0100796)1.65627400
169Failure to thrive in infancy (HP:0001531)1.65616447
170Photophobia (HP:0000613)1.65280640
171Akinesia (HP:0002304)1.65220251
172Papilledema (HP:0001085)1.65212529
173Heterotopia (HP:0002282)1.65079162
174Pheochromocytoma (HP:0002666)1.65050101
175Dysmetria (HP:0001310)1.64877234
176Fetal akinesia sequence (HP:0001989)1.64549878
177Abnormality of the aortic arch (HP:0012303)1.63360035
178Abnormality of the septum pellucidum (HP:0007375)1.62994576
179Steppage gait (HP:0003376)1.61871324
180Premature skin wrinkling (HP:0100678)1.61746970
181Lower limb asymmetry (HP:0100559)1.61337428
182Lower limb muscle weakness (HP:0007340)1.60911710
183Cerebral inclusion bodies (HP:0100314)1.60581519
184Ventricular fibrillation (HP:0001663)1.59696072
185Optic disc pallor (HP:0000543)1.59020355
186Abnormality of the calf musculature (HP:0001430)1.58817061
187Spastic gait (HP:0002064)1.58470285
188Muscle hypertrophy of the lower extremities (HP:0008968)1.57990685
189Megalencephaly (HP:0001355)1.56940990
190Dialeptic seizures (HP:0011146)1.55368021
191Mutism (HP:0002300)1.55301853
192Anosmia (HP:0000458)1.54763103
193Absent speech (HP:0001344)1.54010915
194Dysdiadochokinesis (HP:0002075)1.53887091
195Split foot (HP:0001839)1.53382319
196Thickened helices (HP:0000391)1.52508016
197Preauricular pit (HP:0004467)1.51725569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.36050518
2TRIB33.35759378
3CASK3.31413476
4STK392.73162796
5MAP4K12.68522260
6ERN12.39833633
7FGFR42.39027646
8PRPF4B2.17753267
9KDR2.17402431
10SIK12.16234538
11PHKG22.04212194
12PHKG12.04212194
13MAP2K72.01436829
14EPHB12.00515184
15NTRK31.92758591
16RIPK11.88857262
17EPHB21.86752965
18BMPR1B1.86154835
19MAP3K71.85557589
20PKN11.81153368
21EPHA41.75942499
22MAP2K31.74606196
23STK381.71543061
24MAPK131.71277583
25DAPK21.71165072
26BLK1.70322956
27ZAP701.69181187
28TNK21.60678500
29PAK61.57799068
30BCR1.54708701
31OXSR11.53860017
32TNIK1.52545369
33RIPK41.51164436
34MAP3K41.49133281
35TYK21.47014846
36LIMK11.45606486
37UHMK11.43457007
38SGK4941.41914650
39SGK2231.41914650
40GRK11.40720533
41MAP3K61.40610124
42GRK51.37564280
43TIE11.37389648
44MAP3K111.32910484
45IRAK21.32521950
46CSK1.31267727
47NTRK21.29758051
48DYRK21.26630021
49MAP3K91.25785546
50CDK51.22387052
51WNK41.22360644
52PAK31.20671681
53CDK121.20583245
54DDR21.20001693
55SMG11.19989669
56WNK11.18314562
57GRK61.17589167
58FGFR31.16595336
59EEF2K1.16429443
60NEK61.13312660
61NTRK11.13203370
62MINK11.10987732
63PRKCE1.10984774
64MAP3K131.10983588
65PKN21.09742838
66PRKD21.08350969
67SIK31.07692159
68TGFBR21.07628054
69MYLK1.07612081
70PTK2B1.06823364
71CAMK2A1.06563966
72PDPK11.04276864
73INSRR1.03809471
74CAMK2B1.01489678
75JAK31.00735156
76ROCK21.00226498
77PDGFRA1.00016486
78PDK10.99777620
79PTK60.99701911
80MAP3K30.99308067
81KSR20.98754022
82CAMK2D0.97921290
83ITK0.96851253
84FER0.95972614
85BTK0.94856098
86PINK10.94222128
87HCK0.93842202
88CDK190.92377582
89MAPKAPK50.91982390
90MAP3K10.88160878
91PLK20.87837184
92PRKAA20.87666644
93GRK70.85457722
94MAP2K20.84871365
95BMX0.84730460
96DYRK1B0.82796135
97RET0.80992021
98ERBB30.80574511
99SGK30.80010189
100AKT30.79536599
101LCK0.79436622
102LMTK20.78812071
103CDC42BPA0.77194368
104FGR0.77077797
105PRKD30.77066010
106MTOR0.76175945
107BMPR20.75257637
108MAP3K100.75098859
109PDGFRB0.74645997
110HIPK20.73727221
111ROCK10.72592085
112DYRK1A0.72398818
113TTN0.69916905
114JAK10.68861637
115RPS6KL10.68613450
116RPS6KC10.68613450
117SYK0.68338194
118MAPK120.67494852
119ADRBK10.67005635
120MUSK0.66922597
121TYRO30.66364554
122TESK10.66047404
123ICK0.65134746
124TAOK10.64810905
125CDK140.63266620
126MAPK110.62938765
127CAMK2G0.61993661
128MST1R0.61891877
129IRAK10.61722017
130FGFR20.61303688
131CDK180.58634528
132RPS6KA60.58620362
133PRKD10.58296341
134MAPK150.57567585
135ADRBK20.57507669
136CDK150.57256404
137FYN0.57178860
138MARK20.55106155
139PIK3CA0.55045697
140RPS6KA20.54678358
141SGK10.54453320
142PAK40.54348343
143EPHA30.53871538
144ERBB20.53866078
145DAPK30.53328710
146TRPM70.52998830
147MARK30.51883816
148CSNK1A1L0.51361319
149CLK10.51297470
150PRKG20.50756816
151CDK11A0.50254578
152LYN0.49885373
153SGK20.49562249
154CAMK10.49505277
155STK110.48989078
156CSNK1G20.48665176
157PRKAA10.48510118
158MAPK70.47585597
159CAMKK10.46853616
160PRKCZ0.45949791
161JAK20.45859098
162TBK10.44256124
163TEC0.43443859
164SIK20.42358706
165MAP3K140.41291969
166FES0.41222180
167PRKCG0.40752241
168PRKACA0.40559322
169DMPK0.39720204
170CAMK40.38630125
171PRKCH0.38387469
172BRD40.37694365

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.72716527
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.51592669
3Olfactory transduction_Homo sapiens_hsa047402.25508972
4Other glycan degradation_Homo sapiens_hsa005112.20484806
5Nicotine addiction_Homo sapiens_hsa050332.12738539
6Synaptic vesicle cycle_Homo sapiens_hsa047212.10624615
7Notch signaling pathway_Homo sapiens_hsa043301.99022444
8Morphine addiction_Homo sapiens_hsa050321.90006256
9Glutamatergic synapse_Homo sapiens_hsa047241.84791161
10Axon guidance_Homo sapiens_hsa043601.83654089
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79330369
12GABAergic synapse_Homo sapiens_hsa047271.75833009
13Circadian entrainment_Homo sapiens_hsa047131.73955924
14Acute myeloid leukemia_Homo sapiens_hsa052211.73405215
15B cell receptor signaling pathway_Homo sapiens_hsa046621.65654401
16Cholinergic synapse_Homo sapiens_hsa047251.54856983
17T cell receptor signaling pathway_Homo sapiens_hsa046601.50539286
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49319376
19Serotonergic synapse_Homo sapiens_hsa047261.47986366
20Osteoclast differentiation_Homo sapiens_hsa043801.47028349
21Cardiac muscle contraction_Homo sapiens_hsa042601.43723475
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43222633
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43120661
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.41112347
25Dilated cardiomyopathy_Homo sapiens_hsa054141.41075612
26Salivary secretion_Homo sapiens_hsa049701.40626151
27Dopaminergic synapse_Homo sapiens_hsa047281.38900535
28Taste transduction_Homo sapiens_hsa047421.38403920
29Inositol phosphate metabolism_Homo sapiens_hsa005621.35591266
30Cocaine addiction_Homo sapiens_hsa050301.33983614
31Non-small cell lung cancer_Homo sapiens_hsa052231.33267077
32Chronic myeloid leukemia_Homo sapiens_hsa052201.33262433
33Malaria_Homo sapiens_hsa051441.28165169
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26759889
35Gastric acid secretion_Homo sapiens_hsa049711.26387461
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26009084
37Renin secretion_Homo sapiens_hsa049241.25348345
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23288383
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21809698
40Amphetamine addiction_Homo sapiens_hsa050311.20889270
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.20071073
42Insulin secretion_Homo sapiens_hsa049111.18036189
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17798157
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17115363
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13280825
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13119171
47Oxytocin signaling pathway_Homo sapiens_hsa049211.12380792
48Collecting duct acid secretion_Homo sapiens_hsa049661.11297472
49Glycerolipid metabolism_Homo sapiens_hsa005611.10825862
50Calcium signaling pathway_Homo sapiens_hsa040201.10772098
51Long-term depression_Homo sapiens_hsa047301.09946116
52Pancreatic secretion_Homo sapiens_hsa049721.09634830
53Long-term potentiation_Homo sapiens_hsa047201.08289783
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08106458
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05965319
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.05859085
57Platelet activation_Homo sapiens_hsa046111.05251262
58Pancreatic cancer_Homo sapiens_hsa052121.04703840
59Gap junction_Homo sapiens_hsa045401.04217674
60ABC transporters_Homo sapiens_hsa020101.02874008
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.01950710
62Ether lipid metabolism_Homo sapiens_hsa005651.01634757
63Insulin signaling pathway_Homo sapiens_hsa049101.00905252
64Complement and coagulation cascades_Homo sapiens_hsa046100.99573712
65ECM-receptor interaction_Homo sapiens_hsa045120.99387134
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99362241
67mTOR signaling pathway_Homo sapiens_hsa041500.99153994
68GnRH signaling pathway_Homo sapiens_hsa049120.98919655
69Oxidative phosphorylation_Homo sapiens_hsa001900.98446122
70Insulin resistance_Homo sapiens_hsa049310.98273642
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97034452
72Colorectal cancer_Homo sapiens_hsa052100.96534007
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96503734
74cAMP signaling pathway_Homo sapiens_hsa040240.95789689
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95749196
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95357031
77Primary immunodeficiency_Homo sapiens_hsa053400.94953674
78Fatty acid biosynthesis_Homo sapiens_hsa000610.93866580
79Vibrio cholerae infection_Homo sapiens_hsa051100.93698141
80Melanogenesis_Homo sapiens_hsa049160.92863578
81Prolactin signaling pathway_Homo sapiens_hsa049170.92519044
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92088313
83Sphingolipid metabolism_Homo sapiens_hsa006000.91698141
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91315887
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91124475
86Toxoplasmosis_Homo sapiens_hsa051450.90691137
87ErbB signaling pathway_Homo sapiens_hsa040120.89165990
88Rheumatoid arthritis_Homo sapiens_hsa053230.88871156
89Alzheimers disease_Homo sapiens_hsa050100.88485101
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.87882752
91FoxO signaling pathway_Homo sapiens_hsa040680.87556880
92Endometrial cancer_Homo sapiens_hsa052130.87072868
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86997691
94Tight junction_Homo sapiens_hsa045300.86703694
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85857696
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.84967356
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84929152
98TNF signaling pathway_Homo sapiens_hsa046680.84017387
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83925070
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.83410007
101Lysine degradation_Homo sapiens_hsa003100.82511111
102Staphylococcus aureus infection_Homo sapiens_hsa051500.81047865
103Parkinsons disease_Homo sapiens_hsa050120.80968034
104PPAR signaling pathway_Homo sapiens_hsa033200.79367842
105Ras signaling pathway_Homo sapiens_hsa040140.79318853
106AMPK signaling pathway_Homo sapiens_hsa041520.78977518
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78896663
108Hedgehog signaling pathway_Homo sapiens_hsa043400.75215076
109Basal cell carcinoma_Homo sapiens_hsa052170.74915419
110Rap1 signaling pathway_Homo sapiens_hsa040150.73852019
111HIF-1 signaling pathway_Homo sapiens_hsa040660.73456584
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72321663
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71976648
114Protein digestion and absorption_Homo sapiens_hsa049740.70910075
115Hepatitis B_Homo sapiens_hsa051610.70222396
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70128775
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69786291
118Autoimmune thyroid disease_Homo sapiens_hsa053200.69455758
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68924740
120Wnt signaling pathway_Homo sapiens_hsa043100.67936764
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67548440
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.66636375
123Dorso-ventral axis formation_Homo sapiens_hsa043200.66609178
124MAPK signaling pathway_Homo sapiens_hsa040100.66481681
125Renal cell carcinoma_Homo sapiens_hsa052110.65346547
126Hippo signaling pathway_Homo sapiens_hsa043900.64845488
127Measles_Homo sapiens_hsa051620.64697757
128Estrogen signaling pathway_Homo sapiens_hsa049150.64227732
129Leishmaniasis_Homo sapiens_hsa051400.63422214
130Proteoglycans in cancer_Homo sapiens_hsa052050.63016091
131Tuberculosis_Homo sapiens_hsa051520.62813209
132Endocytosis_Homo sapiens_hsa041440.61476119
133Adherens junction_Homo sapiens_hsa045200.61340790
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61093581
135Focal adhesion_Homo sapiens_hsa045100.61025458
136Ovarian steroidogenesis_Homo sapiens_hsa049130.60794943
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.59751714
138Chemokine signaling pathway_Homo sapiens_hsa040620.59599921
139Influenza A_Homo sapiens_hsa051640.59532321
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.57062264
141Choline metabolism in cancer_Homo sapiens_hsa052310.56989513
142Type II diabetes mellitus_Homo sapiens_hsa049300.56678743
143VEGF signaling pathway_Homo sapiens_hsa043700.56260954
144Hepatitis C_Homo sapiens_hsa051600.55717933
145Hematopoietic cell lineage_Homo sapiens_hsa046400.55339829
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55008487
147Glioma_Homo sapiens_hsa052140.53464792
148Amoebiasis_Homo sapiens_hsa051460.53002896
149AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52694375
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52108688
151Viral myocarditis_Homo sapiens_hsa054160.51912850
152Salmonella infection_Homo sapiens_hsa051320.51847592
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51355626
154Phagosome_Homo sapiens_hsa041450.51149923
155Lysosome_Homo sapiens_hsa041420.51067160
156Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50962072
157Apoptosis_Homo sapiens_hsa042100.50674895
158Steroid biosynthesis_Homo sapiens_hsa001000.50469839
159Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50030855
160Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47232448
161Huntingtons disease_Homo sapiens_hsa050160.44449746
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43935255
163PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43403553

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