GEM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of heat generation (GO:0031652)6.36637863
2regulation of fever generation (GO:0031620)6.33313447
3eosinophil chemotaxis (GO:0048245)6.01928594
4interferon-gamma production (GO:0032609)5.33601100
5regulation of memory T cell differentiation (GO:0043380)5.32241437
6eosinophil migration (GO:0072677)5.30434218
7regulation of heat generation (GO:0031650)5.17231814
8regulation of activation of Janus kinase activity (GO:0010533)5.06884352
9viral protein processing (GO:0019082)4.83632159
10positive regulation of osteoclast differentiation (GO:0045672)4.71123166
11T-helper cell differentiation (GO:0042093)4.67782122
12CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.67782122
13positive regulation of prostaglandin secretion (GO:0032308)4.62119889
14tolerance induction (GO:0002507)4.44331924
15keratan sulfate catabolic process (GO:0042340)4.40483897
16positive regulation of T cell mediated cytotoxicity (GO:0001916)4.25596560
17response to muramyl dipeptide (GO:0032495)4.21155402
18interleukin-1-mediated signaling pathway (GO:0070498)4.17469054
19regulation of prostaglandin secretion (GO:0032306)4.14401426
20negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.13184065
21T cell differentiation involved in immune response (GO:0002292)4.09120020
22alpha-beta T cell differentiation involved in immune response (GO:0002293)4.09120020
23alpha-beta T cell activation involved in immune response (GO:0002287)4.09120020
24regulation of T cell mediated cytotoxicity (GO:0001914)4.06760179
25endothelial cell chemotaxis (GO:0035767)4.00988507
26positive regulation of bone resorption (GO:0045780)3.99568315
27positive regulation of bone remodeling (GO:0046852)3.99568315
28positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.98016113
29negative regulation of bone resorption (GO:0045779)3.93842163
30positive regulation of p38MAPK cascade (GO:1900745)3.80301328
31kidney mesenchyme development (GO:0072074)3.78483300
32cellular response to interleukin-15 (GO:0071350)3.78420582
33regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.77994685
34induction of positive chemotaxis (GO:0050930)3.77537948
35regulation of interleukin-12 biosynthetic process (GO:0045075)3.76146851
36positive regulation of defense response to virus by host (GO:0002230)3.75762453
37positive regulation of astrocyte differentiation (GO:0048711)3.71580131
38skin morphogenesis (GO:0043589)3.69871631
39negative regulation of inclusion body assembly (GO:0090084)3.67986812
40positive regulation of T-helper 1 type immune response (GO:0002827)3.67094490
41response to interleukin-15 (GO:0070672)3.65535592
42positive regulation of interleukin-17 production (GO:0032740)3.64686297
43NIK/NF-kappaB signaling (GO:0038061)3.57312007
44cell adhesion mediated by integrin (GO:0033627)3.56631069
45positive regulation of icosanoid secretion (GO:0032305)3.56196114
46regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.52868316
47regulation of gamma-delta T cell differentiation (GO:0045586)3.45942430
48regulation of mononuclear cell migration (GO:0071675)3.42250109
49negative regulation of bone remodeling (GO:0046851)3.41755256
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.41060752
51regulation of p38MAPK cascade (GO:1900744)3.37784039
52regulation of gamma-delta T cell activation (GO:0046643)3.37318726
53positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.32489331
54wound healing, spreading of epidermal cells (GO:0035313)3.29981363
55lung vasculature development (GO:0060426)3.29073893
56CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.28544905
57mammary gland epithelial cell proliferation (GO:0033598)3.27080255
58negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.26748209
59smooth muscle tissue development (GO:0048745)3.26696837
60lymph node development (GO:0048535)3.26569842
61regulation of leukocyte mediated cytotoxicity (GO:0001910)3.26222371
62nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.25087432
63positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.24662860
64oligosaccharide catabolic process (GO:0009313)3.24459594
65regulation of membrane protein ectodomain proteolysis (GO:0051043)3.24108196
66monocyte chemotaxis (GO:0002548)3.22452309
67positive regulation of extracellular matrix organization (GO:1903055)3.15366347
68entrainment of circadian clock by photoperiod (GO:0043153)3.12511382
69regulation of cell killing (GO:0031341)3.12017672
70positive regulation of myeloid leukocyte differentiation (GO:0002763)3.11561326
71angiogenesis involved in wound healing (GO:0060055)3.11538134
72embryonic process involved in female pregnancy (GO:0060136)3.10179145
73positive thymic T cell selection (GO:0045059)3.09137312
74regulation of vitamin D biosynthetic process (GO:0060556)3.09022653
75mature B cell differentiation involved in immune response (GO:0002313)3.08226165
76G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.08209750
77alpha-beta T cell differentiation (GO:0046632)3.07831399
78positive regulation of macrophage differentiation (GO:0045651)3.05298425
79ER overload response (GO:0006983)3.04856218
80positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.03760299
81cell proliferation involved in kidney development (GO:0072111)3.03733729
82negative regulation of lipid storage (GO:0010888)3.02381767
83vitamin A metabolic process (GO:0006776)3.02335961
84negative regulation of interleukin-10 production (GO:0032693)3.02227572
85virion assembly (GO:0019068)3.02060376
86positive regulation of cell fate commitment (GO:0010455)3.00523337
87T cell activation involved in immune response (GO:0002286)2.99916729
88interleukin-6-mediated signaling pathway (GO:0070102)2.99367246
89fibroblast migration (GO:0010761)2.98727586
90regulation of bone resorption (GO:0045124)2.97128815
91response to progesterone (GO:0032570)2.96721722
92positive regulation of vasculogenesis (GO:2001214)2.96274965
93polyamine biosynthetic process (GO:0006596)2.92171899
94alpha-beta T cell activation (GO:0046631)2.92039563
95positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.91314931
96CD4-positive, alpha-beta T cell activation (GO:0035710)2.89339463
97positive regulation of fatty acid transport (GO:2000193)2.88562140
98cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.87978805
99regulation of defense response to virus by host (GO:0050691)2.87124412
100positive regulation of T-helper cell differentiation (GO:0045624)2.86982055
101response to corticosterone (GO:0051412)2.86897013
102negative regulation of endothelial cell apoptotic process (GO:2000352)2.86487567
103very-low-density lipoprotein particle assembly (GO:0034379)2.86471608
104metanephric mesenchyme development (GO:0072075)2.86466582
105regulation of T-helper 1 type immune response (GO:0002825)2.85843584
106positive regulation of cell killing (GO:0031343)2.85151801
107extracellular matrix assembly (GO:0085029)2.85140883
108positive regulation of receptor recycling (GO:0001921)2.82826827
109negative regulation of tissue remodeling (GO:0034104)2.82424034
110endoderm formation (GO:0001706)2.82153916
111retina vasculature morphogenesis in camera-type eye (GO:0061299)2.81614975
112positive regulation of gamma-delta T cell activation (GO:0046645)2.81143630
113negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79334549
114negative regulation of cell killing (GO:0031342)2.79334549
115JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.79017280
116ovulation from ovarian follicle (GO:0001542)2.78920332
117mammary gland alveolus development (GO:0060749)2.78877320
118adhesion of symbiont to host (GO:0044406)2.78613841
119regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.77159783
120virion attachment to host cell (GO:0019062)2.75866346
121adhesion of symbiont to host cell (GO:0044650)2.75866346
122positive regulation of calcium ion import (GO:0090280)2.74459790
123positive regulation of odontogenesis (GO:0042482)2.73881218
124negative regulation of nitric oxide biosynthetic process (GO:0045019)2.73782350
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.72863738
126antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72863738
127chaperone mediated protein folding requiring cofactor (GO:0051085)2.72743557
128negative regulation of glycoprotein biosynthetic process (GO:0010561)2.72699944
129regulation of icosanoid secretion (GO:0032303)2.71775662
130protein localization to endosome (GO:0036010)2.71553898
131negative regulation of complement activation (GO:0045916)2.71432466
132platelet-derived growth factor receptor signaling pathway (GO:0048008)2.70838710
133membrane raft organization (GO:0031579)2.70371476
134regulation of endothelial cell apoptotic process (GO:2000351)2.70147959
135positive regulation of osteoblast proliferation (GO:0033690)2.69882004
136antigen processing and presentation of endogenous antigen (GO:0019883)2.68943380
137response to hyperoxia (GO:0055093)2.67800726
138response to increased oxygen levels (GO:0036296)2.67800726
139positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67685240
140decidualization (GO:0046697)2.67088312
141regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.67079074
142negative regulation of interleukin-2 production (GO:0032703)2.65417610
143cell migration involved in sprouting angiogenesis (GO:0002042)2.65070480
144glial cell migration (GO:0008347)2.63288605
145signal peptide processing (GO:0006465)2.62649456
146osteoclast differentiation (GO:0030316)2.61830253
147extracellular fibril organization (GO:0043206)2.60633681
148regulation of type B pancreatic cell apoptotic process (GO:2000674)2.60602408
149endocrine hormone secretion (GO:0060986)2.57758948
150vascular endothelial growth factor signaling pathway (GO:0038084)2.56994090
151response to lipoprotein particle (GO:0055094)2.56356474
152positive regulation of metanephros development (GO:0072216)2.55216454
153regulation of collagen metabolic process (GO:0010712)2.52535639
154macroautophagy (GO:0016236)2.52493092
155positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52078610
156positive regulation of positive chemotaxis (GO:0050927)2.50239274
157regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50225659
158negative regulation of smooth muscle cell migration (GO:0014912)2.47074845
159Notch signaling involved in heart development (GO:0061314)2.45827527
160COPI coating of Golgi vesicle (GO:0048205)2.45016787
161Golgi transport vesicle coating (GO:0048200)2.45016787
162cellular response to arsenic-containing substance (GO:0071243)2.44456857
163positive regulation of fat cell differentiation (GO:0045600)2.43868243
164regulation of integrin-mediated signaling pathway (GO:2001044)2.43216563
165negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.43024398
166barbed-end actin filament capping (GO:0051016)2.42829449
167fibril organization (GO:0097435)2.42632661
168wound healing, spreading of cells (GO:0044319)2.41886678
169regulation of positive chemotaxis (GO:0050926)2.40826953
170positive regulation of endothelial cell apoptotic process (GO:2000353)2.40439581
171regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.39959930
172regulation of vitamin metabolic process (GO:0030656)2.38977936
173regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.38709311
174regulation of nitric oxide biosynthetic process (GO:0045428)2.37862107
175surfactant homeostasis (GO:0043129)2.37152854
176cell migration involved in heart development (GO:0060973)2.35484358
177endodermal cell differentiation (GO:0035987)2.35372451
178substrate-dependent cell migration (GO:0006929)2.34955285
179regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.34879500
180mesodermal cell differentiation (GO:0048333)2.34208077
181activation of MAPKKK activity (GO:0000185)2.33106909
182peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.32480208
183tonic smooth muscle contraction (GO:0014820)2.31633705
184cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.31290792
185positive regulation of nitric oxide biosynthetic process (GO:0045429)2.30727787
186mRNA transcription (GO:0009299)2.30619673
187regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30168441
188apoptotic cell clearance (GO:0043277)2.29946964
189chemical homeostasis within a tissue (GO:0048875)2.29598921
190protein heterotrimerization (GO:0070208)2.29559193
191stress fiber assembly (GO:0043149)2.28475876
192retinal metabolic process (GO:0042574)2.27926302
193positive regulation of protein autophosphorylation (GO:0031954)2.27739317
194negative regulation of protein activation cascade (GO:2000258)2.27736692
195dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27634687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.55049950
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.52126523
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse5.13174721
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.25148127
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.53707091
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.41165093
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.24234772
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.15116750
9RUNX_20019798_ChIP-Seq_JUKART_Human2.95304125
10CLOCK_20551151_ChIP-Seq_293T_Human2.74832731
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.61364046
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61139472
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49723638
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.48889671
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.35853104
16* SCL_19346495_ChIP-Seq_HPC-7_Human2.32833298
17MYB_26560356_Chip-Seq_TH2_Human2.20548984
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.15007189
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.14927365
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12656576
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03972456
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.03624828
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91623373
24MYB_26560356_Chip-Seq_TH1_Human1.88259012
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86336489
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86002791
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.85561146
28* TCF7_22412390_ChIP-Seq_EML_Mouse1.80501064
29MYC_22102868_ChIP-Seq_BL_Human1.78717028
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78567042
31VDR_24787735_ChIP-Seq_THP-1_Human1.78412163
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73454892
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72685225
34* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71100793
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.71012670
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.69490192
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.65637872
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.65336831
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.65336831
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64919260
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64703890
42MAF_26560356_Chip-Seq_TH1_Human1.61842325
43* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59207638
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58663195
45VDR_24763502_ChIP-Seq_THP-1_Human1.57915138
46TP53_16413492_ChIP-PET_HCT116_Human1.57755632
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55128615
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54584087
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54206411
50* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53631810
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49759392
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.48210797
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.47867631
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47692606
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47223469
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.44925497
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39570452
58GATA3_27048872_Chip-Seq_THYMUS_Human1.39226649
59* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37861871
60TP53_18474530_ChIP-ChIP_U2OS_Human1.37110242
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36072136
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34293334
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.30733517
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30577674
65* CJUN_26792858_Chip-Seq_BT549_Human1.30052893
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27611590
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26383451
68* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24859087
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.24741495
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22421861
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19990778
72UTX_26944678_Chip-Seq_JUKART_Human1.16883651
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16810293
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16810293
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16795920
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16595386
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16235683
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.16061725
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.15484064
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.15484064
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13304503
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11978262
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11228912
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10869271
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10596278
86* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09750954
87VDR_21846776_ChIP-Seq_THP-1_Human1.09153546
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08283496
89GATA2_19941826_ChIP-Seq_K562_Human1.07912757
90GATA1_19941826_ChIP-Seq_K562_Human1.07729852
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07349657
92* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05824335
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04603534
94SOX2_20726797_ChIP-Seq_SW620_Human1.03720599
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02850729
96* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02802523
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.02577865
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00715504
99TP63_23658742_ChIP-Seq_EP156T_Human1.00419192
100NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99883688
101IGF1R_20145208_ChIP-Seq_DFB_Human0.98647437
102PU_27001747_Chip-Seq_BMDM_Mouse0.98639753
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98379630
104FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98296955
105KDM2B_26808549_Chip-Seq_DND41_Human0.98255291
106UBF1/2_26484160_Chip-Seq_HMECs_Human0.97756622
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96668776
108BRD4_25478319_ChIP-Seq_HGPS_Human0.96041236
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95045918
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94237229
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93865801
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93648935
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.92832083
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92747553
115* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92218805
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91543115
117AHR_22903824_ChIP-Seq_MCF-7_Human0.91136808
118RUNX1_27514584_Chip-Seq_MCF-7_Human0.91092207
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89973059
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.89732332
121* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89295335
122* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87762631
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87549548
124TCF4_18268006_ChIP-ChIP_LS174T_Human0.87489773
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87159461
126* ATF3_27146783_Chip-Seq_COLON_Human0.87125685
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87110033
128RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86715250
129FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86563386
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85908516
131IRF8_21731497_ChIP-ChIP_J774_Mouse0.85194009
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.84222536
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83906350
134MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83395836
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81843128
136PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.81514339
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78735295
138P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78645229
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.78380084
140SA1_22415368_ChIP-Seq_MEFs_Mouse0.78077842
141ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76272324
142RXR_22108803_ChIP-Seq_LS180_Human0.76071344
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75762968
144* CDX2_22108803_ChIP-Seq_LS180_Human0.75555984
145* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.74819818
146KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74663684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.92371867
2MP0002877_abnormal_melanocyte_morpholog3.28954693
3MP0000685_abnormal_immune_system3.26546884
4MP0009840_abnormal_foam_cell3.21230877
5MP0001790_abnormal_immune_system2.99623011
6MP0005387_immune_system_phenotype2.99623011
7MP0005275_abnormal_skin_tensile2.96974894
8MP0004272_abnormal_basement_membrane2.86383704
9MP0005671_abnormal_response_to2.78662827
10MP0005257_abnormal_intraocular_pressure2.77491408
11MP0003950_abnormal_plasma_membrane2.76922246
12MP0010368_abnormal_lymphatic_system2.75992868
13MP0005000_abnormal_immune_tolerance2.48306646
14MP0009785_altered_susceptibility_to2.45208455
15MP0001800_abnormal_humoral_immune2.43694921
16MP0003763_abnormal_thymus_physiology2.43671490
17MP0002405_respiratory_system_inflammati2.41251301
18MP0002009_preneoplasia2.37597226
19MP0002723_abnormal_immune_serum2.26899761
20MP0001835_abnormal_antigen_presentation2.24420099
21MP0003091_abnormal_cell_migration2.20873930
22MP0001879_abnormal_lymphatic_vessel2.14568258
23MP0004510_myositis2.07444807
24MP0001958_emphysema2.06946675
25MP0010155_abnormal_intestine_physiology2.04836879
26MP0003011_delayed_dark_adaptation2.02356018
27MP0002452_abnormal_antigen_presenting1.98099916
28MP0004947_skin_inflammation1.94896248
29MP0003300_gastrointestinal_ulcer1.94433926
30MP0002420_abnormal_adaptive_immunity1.93296492
31MP0002933_joint_inflammation1.92939798
32MP0001819_abnormal_immune_cell1.92172172
33MP0008961_abnormal_basal_metabolism1.90041818
34MP0001873_stomach_inflammation1.89137772
35MP0003436_decreased_susceptibility_to1.84879961
36MP0002166_altered_tumor_susceptibility1.77729388
37MP0002148_abnormal_hypersensitivity_rea1.76291581
38MP0001502_abnormal_circadian_rhythm1.73993541
39MP0005058_abnormal_lysosome_morphology1.67678082
40MP0001851_eye_inflammation1.66595234
41MP0005165_increased_susceptibility_to1.66133196
42MP0002419_abnormal_innate_immunity1.66119413
43MP0002277_abnormal_respiratory_mucosa1.66103044
44MP0003303_peritoneal_inflammation1.63808054
45MP0009780_abnormal_chondrocyte_physiolo1.60203981
46MP0002006_tumorigenesis1.59470881
47MP0003866_abnormal_defecation1.58605196
48MP0001845_abnormal_inflammatory_respons1.57655788
49MP0002138_abnormal_hepatobiliary_system1.57572585
50MP0002295_abnormal_pulmonary_circulatio1.57560033
51MP0004782_abnormal_surfactant_physiolog1.56844296
52MP0005595_abnormal_vascular_smooth1.55874673
53MP0000767_abnormal_smooth_muscle1.54047450
54MP0005025_abnormal_response_to1.53775167
55MP0000703_abnormal_thymus_morphology1.52473784
56MP0003828_pulmonary_edema1.51997729
57MP0002998_abnormal_bone_remodeling1.51227754
58MP0002398_abnormal_bone_marrow1.51173496
59MP0002896_abnormal_bone_mineralization1.50576260
60MP0000343_altered_response_to1.50553703
61MP0000249_abnormal_blood_vessel1.46411114
62MP0000716_abnormal_immune_system1.45598566
63MP0008007_abnormal_cellular_replicative1.44896533
64MP0001533_abnormal_skeleton_physiology1.37406608
65MP0004883_abnormal_blood_vessel1.37154115
66MP0003638_abnormal_response/metabolism_1.36238977
67MP0000604_amyloidosis1.35063510
68MP0005076_abnormal_cell_differentiation1.33825249
69MP0003075_altered_response_to1.32998882
70MP0002722_abnormal_immune_system1.32853034
71MP0001881_abnormal_mammary_gland1.31527416
72MP0009384_cardiac_valve_regurgitation1.30720224
73MP0004264_abnormal_extraembryonic_tissu1.29131538
74MP0003191_abnormal_cellular_cholesterol1.28690422
75MP0000751_myopathy1.28089986
76MP0002060_abnormal_skin_morphology1.28061111
77MP0009333_abnormal_splenocyte_physiolog1.27744709
78MP0000465_gastrointestinal_hemorrhage1.27095668
79MP0002928_abnormal_bile_duct1.26207470
80MP0005167_abnormal_blood-brain_barrier1.25044779
81MP0000689_abnormal_spleen_morphology1.23590952
82MP0005503_abnormal_tendon_morphology1.22860455
83MP0010386_abnormal_urinary_bladder1.22161472
84MP0003448_altered_tumor_morphology1.21780476
85MP0003705_abnormal_hypodermis_morpholog1.19850441
86MP0004808_abnormal_hematopoietic_stem1.19532237
87MP0000750_abnormal_muscle_regeneration1.18035748
88MP0003195_calcinosis1.16298542
89MP0003329_amyloid_beta_deposits1.16037905
90MP0003943_abnormal_hepatobiliary_system1.15957452
91MP0006054_spinal_hemorrhage1.15143284
92MP0009278_abnormal_bone_marrow1.14068969
93MP0002429_abnormal_blood_cell1.13821758
94MP0006082_CNS_inflammation1.12129172
95MP0001853_heart_inflammation1.11974169
96MP0005670_abnormal_white_adipose1.08974304
97MP0002332_abnormal_exercise_endurance1.08972623
98MP0008004_abnormal_stomach_pH1.08669795
99MP0005164_abnormal_response_to1.08477003
100MP0009764_decreased_sensitivity_to1.07935054
101MP0005390_skeleton_phenotype1.06753509
102MP0005166_decreased_susceptibility_to1.03027663
103MP0003453_abnormal_keratinocyte_physiol1.02467716
104MP0005197_abnormal_uvea_morphology1.02357990
105MP0000678_abnormal_parathyroid_gland0.99615802
106MP0003795_abnormal_bone_structure0.99043511
107MP0003045_fibrosis0.97835965
108MP0000858_altered_metastatic_potential0.97448532
109MP0005464_abnormal_platelet_physiology0.97367348
110MP0002972_abnormal_cardiac_muscle0.97103273
111MP0004084_abnormal_cardiac_muscle0.96980693
112MP0000013_abnormal_adipose_tissue0.95633360
113MP0000534_abnormal_ureter_morphology0.95607349
114MP0008995_early_reproductive_senescence0.95343572
115MP0001501_abnormal_sleep_pattern0.94607362
116MP0001243_abnormal_dermal_layer0.91684220
117MP0002090_abnormal_vision0.90083390
118MP0002693_abnormal_pancreas_physiology0.87868654
119MP0010352_gastrointestinal_tract_polyps0.87740936
120MP0005620_abnormal_muscle_contractility0.87563763
121MP0002108_abnormal_muscle_morphology0.87538660
122MP0002136_abnormal_kidney_physiology0.86732714
123MP0000462_abnormal_digestive_system0.86678989
124MP0005310_abnormal_salivary_gland0.86610095
125MP0004036_abnormal_muscle_relaxation0.85800605
126MP0001270_distended_abdomen0.85204383
127MP0008469_abnormal_protein_level0.84612002
128MP0002254_reproductive_system_inflammat0.83003863
129MP0005330_cardiomyopathy0.82470594
130MP0005397_hematopoietic_system_phenotyp0.82083296
131MP0001545_abnormal_hematopoietic_system0.82083296
132MP0000749_muscle_degeneration0.81999650
133MP0008438_abnormal_cutaneous_collagen0.81325029
134MP0001542_abnormal_bone_strength0.80588084
135MP0005508_abnormal_skeleton_morphology0.78965189
136MP0001191_abnormal_skin_condition0.77720002
137MP0001299_abnormal_eye_distance/0.77316175
138MP0000613_abnormal_salivary_gland0.77226536
139MP0000163_abnormal_cartilage_morphology0.76504673
140MP0005367_renal/urinary_system_phenotyp0.76265862
141MP0000516_abnormal_urinary_system0.76265862
142MP0002139_abnormal_hepatobiliary_system0.76063636
143MP0003279_aneurysm0.75206366
144MP0000733_abnormal_muscle_development0.74817641
145MP0000490_abnormal_crypts_of0.74020785
146MP0003690_abnormal_glial_cell0.73688959
147MP0000003_abnormal_adipose_tissue0.73644305
148MP0001614_abnormal_blood_vessel0.73422602
149MP0000920_abnormal_myelination0.72373292
150MP0005023_abnormal_wound_healing0.72130909
151MP0003566_abnormal_cell_adhesion0.71745923
152MP0002168_other_aberrant_phenotype0.69955393
153MP0005647_abnormal_sex_gland0.69727005
154MP0010030_abnormal_orbit_morphology0.68201023
155MP0005375_adipose_tissue_phenotype0.62058316

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)8.13085970
2Optic neuritis (HP:0100653)8.13085970
3Orchitis (HP:0100796)7.51890570
4Increased density of long bones (HP:0006392)7.27667062
5Myositis (HP:0100614)6.84240956
6Persistence of primary teeth (HP:0006335)6.40024027
7Keratoconjunctivitis sicca (HP:0001097)5.69355369
8Keratoconjunctivitis (HP:0001096)5.38468430
9Abnormality of glycolipid metabolism (HP:0010969)5.24931016
10Abnormality of liposaccharide metabolism (HP:0010968)5.24931016
11Abnormality of glycosphingolipid metabolism (HP:0004343)5.24931016
12Protrusio acetabuli (HP:0003179)4.47612746
13Arterial thrombosis (HP:0004420)4.40148763
14Premature rupture of membranes (HP:0001788)4.37553329
15Pulmonary infiltrates (HP:0002113)4.15310270
16IgM deficiency (HP:0002850)4.08361122
17Premature loss of primary teeth (HP:0006323)3.79219571
18Neurofibrillary tangles (HP:0002185)3.28963147
19Nuclear cataract (HP:0100018)3.19655239
20Interstitial pulmonary disease (HP:0006530)3.10918835
21Hemoptysis (HP:0002105)3.08502026
22Osteolytic defects of the hand bones (HP:0009699)3.07756894
23Osteolytic defects of the phalanges of the hand (HP:0009771)3.07756894
24Pulmonary artery stenosis (HP:0004415)3.06700155
25Vasculitis (HP:0002633)3.06225697
26Loss of speech (HP:0002371)3.05200659
27Abnormality of polysaccharide metabolism (HP:0011012)3.04931593
28Abnormality of glycosaminoglycan metabolism (HP:0004371)3.04931593
29Abnormality of mucopolysaccharide metabolism (HP:0011020)3.04931593
30Keratitis (HP:0000491)3.02648242
31Vascular tortuosity (HP:0004948)3.01800649
32Dysostosis multiplex (HP:0000943)3.01087305
33Rhinitis (HP:0012384)2.97172694
34Ankle contracture (HP:0006466)2.93898399
35Urinary glycosaminoglycan excretion (HP:0003541)2.89336648
36Mucopolysacchariduria (HP:0008155)2.89336648
37Arterial tortuosity (HP:0005116)2.85036482
38Elevated erythrocyte sedimentation rate (HP:0003565)2.84311259
39Abnormality of the nasal septum (HP:0000419)2.82966197
40Axonal loss (HP:0003447)2.78579554
41Pulmonary embolism (HP:0002204)2.78089815
42Short nail (HP:0001799)2.77319061
43Upper limb muscle weakness (HP:0003484)2.77216217
44Encephalitis (HP:0002383)2.70517167
45Wormian bones (HP:0002645)2.69632404
46Systemic lupus erythematosus (HP:0002725)2.67218586
47Autoimmune hemolytic anemia (HP:0001890)2.65096447
48IgA deficiency (HP:0002720)2.63323367
49Vacuolated lymphocytes (HP:0001922)2.61423264
50Eczematoid dermatitis (HP:0000976)2.60024368
51Gangrene (HP:0100758)2.59817119
52Increased CSF protein (HP:0002922)2.55678365
53Myocardial infarction (HP:0001658)2.54251426
54Distal lower limb muscle weakness (HP:0009053)2.48081960
55Thyroiditis (HP:0100646)2.47872773
56Glomerulopathy (HP:0100820)2.45904533
57Stomatitis (HP:0010280)2.45784664
58Broad metatarsal (HP:0001783)2.45191129
59Cranial hyperostosis (HP:0004437)2.45083371
60Alopecia of scalp (HP:0002293)2.43246116
61Cerebral aneurysm (HP:0004944)2.42829028
62Hypoglycemic seizures (HP:0002173)2.41306446
63Anorexia (HP:0002039)2.39509144
64Bladder diverticulum (HP:0000015)2.36967503
65Mutism (HP:0002300)2.36400206
66Abnormal albumin level (HP:0012116)2.33590050
67Hypoalbuminemia (HP:0003073)2.33590050
68Gastrointestinal stroma tumor (HP:0100723)2.32264184
69Asymmetric septal hypertrophy (HP:0001670)2.32074341
70Joint stiffness (HP:0001387)2.30518754
71Meningitis (HP:0001287)2.30353712
72Osteomyelitis (HP:0002754)2.29211577
73Symptomatic seizures (HP:0011145)2.27226319
74Spastic diplegia (HP:0001264)2.25220576
75Soft skin (HP:0000977)2.24276894
76Aortic regurgitation (HP:0001659)2.23981518
77Increased cerebral lipofuscin (HP:0011813)2.21588615
78Adactyly (HP:0009776)2.19774781
79Recurrent bronchitis (HP:0002837)2.19580261
80Increased connective tissue (HP:0009025)2.18212104
81Follicular hyperkeratosis (HP:0007502)2.17260963
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.16048706
83Abnormality of complement system (HP:0005339)2.15467428
84Aneurysm (HP:0002617)2.12994653
85Thoracolumbar scoliosis (HP:0002944)2.12166530
86Abnormality of the pericardium (HP:0001697)2.11924568
87Abnormality of primary teeth (HP:0006481)2.11643817
88Ulnar claw (HP:0001178)2.10648579
89Joint swelling (HP:0001386)2.10628626
90Natal tooth (HP:0000695)2.10211703
91Aortic valve stenosis (HP:0001650)2.09635797
92Dilatation of the ascending aorta (HP:0005111)2.09467253
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07674604
94Recurrent fungal infections (HP:0002841)2.06971845
95Atrophic scars (HP:0001075)2.06433337
96Pancreatitis (HP:0001733)2.05555376
97Thrombophlebitis (HP:0004418)2.04217762
98Shallow orbits (HP:0000586)2.03695787
99Cerebral inclusion bodies (HP:0100314)2.03528175
100Abnormality of eosinophils (HP:0001879)2.02918838
101Bradycardia (HP:0001662)2.01306216
102Xerostomia (HP:0000217)2.00883802
103Complement deficiency (HP:0004431)2.00638868
104Depressed nasal tip (HP:0000437)1.99225177
105Vertigo (HP:0002321)1.98823209
106Abnormality of the pleura (HP:0002103)1.98712724
107Irregular vertebral endplates (HP:0003301)1.98707101
108Esophageal varix (HP:0002040)1.96884019
109Metaphyseal dysplasia (HP:0100255)1.93704118
110Abnormality of the endocardium (HP:0004306)1.92992396
111Arthralgia (HP:0002829)1.92335362
112Hypoplasia of the odontoid process (HP:0003311)1.91898085
113Bone cyst (HP:0012062)1.91035232
114Abnormality of T cell number (HP:0011839)1.90853057
115Ovoid vertebral bodies (HP:0003300)1.89918307
116T lymphocytopenia (HP:0005403)1.88964855
117Hematochezia (HP:0002573)1.86458764
118Cardiovascular calcification (HP:0011915)1.85464817
119Hyperglycemia (HP:0003074)1.85177029
120Beaking of vertebral bodies (HP:0004568)1.84870403
121Aortic dissection (HP:0002647)1.84768276
122Abnormality of the distal phalanges of the toes (HP:0010182)1.84693161
123Acne (HP:0001061)1.84542522
124Glucose intolerance (HP:0000833)1.83002054
125Type 1 muscle fiber predominance (HP:0003803)1.82741311
126Aortic aneurysm (HP:0004942)1.81627483
127Hypokinesia (HP:0002375)1.80355664
128Thick nail (HP:0001805)1.80224645
129Biconcave vertebral bodies (HP:0004586)1.79515851
130Inflammation of the large intestine (HP:0002037)1.79500323
131Spinal rigidity (HP:0003306)1.78806593
132Glomerulonephritis (HP:0000099)1.78717533
133Colitis (HP:0002583)1.77837527
134Severe combined immunodeficiency (HP:0004430)1.77560322
135Segmental peripheral demyelination/remyelination (HP:0003481)1.77552173
136Absent hand (HP:0004050)1.77441980
137Vertebral compression fractures (HP:0002953)1.77150698
138Malnutrition (HP:0004395)1.76917010
139Polyneuropathy (HP:0001271)1.75645504
140Increased IgE level (HP:0003212)1.75490601
141Abnormality of the odontoid process (HP:0003310)1.74425285
142Mitral stenosis (HP:0001718)1.74273122
143Slender build (HP:0001533)1.74218619
144Abnormality of T cells (HP:0002843)1.73811296
145Hyperinsulinemic hypoglycemia (HP:0000825)1.73746325
146J-shaped sella turcica (HP:0002680)1.73502865
147Distal lower limb amyotrophy (HP:0008944)1.73486009
148Amyloidosis (HP:0011034)1.73125620
149Elbow flexion contracture (HP:0002987)1.72449124
150Mitral regurgitation (HP:0001653)1.71688903
151Spontaneous hematomas (HP:0007420)1.71587550
152Gingival overgrowth (HP:0000212)1.71402228
153Stomach cancer (HP:0012126)1.71121901
154Growth hormone excess (HP:0000845)1.71085084
155Hoarse voice (HP:0001609)1.70325886
156Choroideremia (HP:0001139)1.70103108
157Long toe (HP:0010511)1.70070666
158Neonatal short-limb short stature (HP:0008921)1.69828997
159Portal hypertension (HP:0001409)1.68869638
160Reduced subcutaneous adipose tissue (HP:0003758)1.68589579
161Hypoplasia of the iris (HP:0007676)1.68052424
162Mediastinal lymphadenopathy (HP:0100721)1.68036039
163Mildly elevated creatine phosphokinase (HP:0008180)1.67988228
164Cervical subluxation (HP:0003308)1.67623585
165Pulmonary hypertension (HP:0002092)1.67540612
166Skin nodule (HP:0200036)1.67164209
167Abnormality of the sella turcica (HP:0002679)1.66789710
168Gastrointestinal inflammation (HP:0004386)1.66524565
169Abnormality of the fingertips (HP:0001211)1.66210513
170Cerebral ischemia (HP:0002637)1.66113233
171Alveolar cell carcinoma (HP:0006519)1.65548348
172Cellulitis (HP:0100658)1.65540142
173Increased neuronal autofluorescent lipopigment (HP:0002074)1.64883874
174Hydroxyprolinuria (HP:0003080)1.64559609
175Abnormality of proline metabolism (HP:0010907)1.64559609
176Tetraparesis (HP:0002273)1.63896573
177Abnormality of the nasal mucosa (HP:0000433)1.62444760
178Bone pain (HP:0002653)1.62303699
179Hypophosphatemia (HP:0002148)1.62105438
180Rectal prolapse (HP:0002035)1.62063546
181B lymphocytopenia (HP:0010976)1.61493127
182Abnormality of B cell number (HP:0010975)1.61493127
183Insulin-resistant diabetes mellitus (HP:0000831)1.61480192
184Spondylolisthesis (HP:0003302)1.61301780
185Hepatosplenomegaly (HP:0001433)1.60828955
186Thin bony cortex (HP:0002753)1.60444411
187Striae distensae (HP:0001065)1.56332577
188Paresthesia (HP:0003401)1.55237390

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK36.35109668
2MAPK154.66277767
3TAOK34.52037948
4TXK4.17113008
5EPHA23.42434947
6MYLK3.30389346
7TSSK63.13645472
8MAP3K143.12629717
9DDR22.88334838
10INSRR2.53042061
11STK38L2.44335894
12MST1R2.37728073
13ITK2.34799162
14TBK12.27977414
15MAP4K12.09132658
16ABL22.04681977
17LATS22.02603405
18PDGFRA2.01528522
19AKT31.96825021
20MAPKAPK51.93132551
21IKBKB1.91934604
22TEC1.91833770
23TESK11.91566243
24LMTK21.89540766
25JAK11.86680641
26MET1.82189744
27IKBKE1.78843033
28PTK21.76326379
29FER1.75796002
30LIMK11.75521032
31TAOK21.74149950
32CHUK1.66466798
33NUAK11.65525748
34EPHA31.61365556
35ERBB41.58255300
36PDK21.57896202
37MOS1.57487616
38PIM11.54751233
39PAK21.52644668
40EPHB11.50743832
41GRK71.50524568
42TTN1.50080373
43NLK1.49307563
44TGFBR21.48083893
45BTK1.44436017
46IRAK21.43312377
47NEK61.30577305
48JAK31.27536068
49NME21.25867662
50ZAP701.15935315
51STK241.14996330
52NEK91.11970135
53PIM21.10023323
54KIT1.08338830
55STK381.07347191
56EIF2AK31.04949820
57IRAK11.02979855
58CDC42BPA1.02681413
59MAP2K21.01399493
60EPHB21.00407702
61FGFR31.00124739
62ERN10.98945361
63EEF2K0.98830846
64GSK3A0.98484904
65IRAK40.97778783
66BCR0.96688581
67MAPK70.94935236
68PAK40.94628493
69BCKDK0.93978193
70CDK30.92909598
71MAP3K30.90528306
72ROCK10.87466879
73MAP3K120.84722147
74HIPK20.84462494
75PRKCE0.83679134
76VRK10.83428564
77STK100.82073323
78ERBB30.81093329
79MAP2K30.80359234
80TIE10.80196610
81PTK2B0.80154157
82SYK0.79302282
83FGFR40.77820950
84TGFBR10.77642955
85MAP3K60.75711590
86HCK0.70919206
87CDK80.69349258
88SIK10.67679571
89TRPM70.67462345
90PTK60.63961298
91PAK30.63741395
92LATS10.63605862
93LCK0.63306794
94CDK120.62331580
95CAMK2D0.61752532
96BMX0.61558748
97CAMK2G0.61416063
98RPS6KA40.60673215
99FGFR10.59577240
100NTRK10.58957602
101ADRBK20.58482252
102MATK0.58382673
103MAPK120.58342341
104TYK20.58240487
105GRK60.58058082
106PASK0.57322141
107ARAF0.56382635
108MAP3K110.56375146
109MAP3K10.54023516
110MAPKAPK20.51170877
111DAPK30.49992168
112ROCK20.48079250
113PRKD10.48076555
114RPS6KA20.47764440
115PDGFRB0.45660885
116ADRBK10.45214279
117TAOK10.44530956
118FRK0.43947040
119IGF1R0.43901579
120CLK10.43643608
121MARK30.43546539
122BMPR1B0.43212598
123LYN0.42559940
124PAK10.42545590
125DYRK1B0.41924026
126RPS6KB10.41018298
127DMPK0.39679479
128JAK20.39455303
129GRK10.38960891
130MUSK0.38956319
131RPS6KA50.37835552
132CSNK1A1L0.37261085
133MELK0.36853448
134BMPR20.36726783
135MTOR0.36600958
136MAPKAPK30.36199831
137RIPK10.35012806
138MKNK20.34775201
139RPS6KA10.33880320
140CDK90.33845122
141MST40.33721588
142BRD40.32906915
143PRKCI0.32407460
144CDK60.31416869
145TNK20.31361019
146MAPK30.31348714
147PRKG20.30917187
148PRKCQ0.30689611
149MAPK40.28862721
150RPS6KB20.28590031
151SIK30.28345672
152INSR0.27884101
153ABL10.27735274
154FES0.27480686
155MAP3K70.26789151
156CSK0.26488716
157MAP3K20.25719255
158PRKCH0.24641887
159MAPK10.24570108
160STK30.22855686

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.56262560
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.05614994
3Osteoclast differentiation_Homo sapiens_hsa043802.97210288
4Circadian rhythm_Homo sapiens_hsa047102.77519971
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.71131023
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.67954413
7TNF signaling pathway_Homo sapiens_hsa046682.48486361
8Lysosome_Homo sapiens_hsa041422.39265949
9Antigen processing and presentation_Homo sapiens_hsa046122.37687821
10Leishmaniasis_Homo sapiens_hsa051402.20453976
11Other glycan degradation_Homo sapiens_hsa005112.17809069
12Graft-versus-host disease_Homo sapiens_hsa053322.15093380
13Legionellosis_Homo sapiens_hsa051341.96584814
14T cell receptor signaling pathway_Homo sapiens_hsa046601.94516411
15Measles_Homo sapiens_hsa051621.92516967
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91942031
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.91016608
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.89031204
19B cell receptor signaling pathway_Homo sapiens_hsa046621.81705491
20Primary immunodeficiency_Homo sapiens_hsa053401.79107178
21Hematopoietic cell lineage_Homo sapiens_hsa046401.72869319
22Toxoplasmosis_Homo sapiens_hsa051451.66500871
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.64384615
24Complement and coagulation cascades_Homo sapiens_hsa046101.63304849
25Sphingolipid metabolism_Homo sapiens_hsa006001.63262762
26Rheumatoid arthritis_Homo sapiens_hsa053231.63083869
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61654703
28Vibrio cholerae infection_Homo sapiens_hsa051101.61356064
29Mineral absorption_Homo sapiens_hsa049781.59939702
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.58327772
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54722792
32Prolactin signaling pathway_Homo sapiens_hsa049171.51931291
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51476987
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34441814
35Malaria_Homo sapiens_hsa051441.33375497
36Collecting duct acid secretion_Homo sapiens_hsa049661.28805255
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28008991
38Dilated cardiomyopathy_Homo sapiens_hsa054141.26371892
39Influenza A_Homo sapiens_hsa051641.24849469
40Vitamin digestion and absorption_Homo sapiens_hsa049771.24784650
41Apoptosis_Homo sapiens_hsa042101.23512575
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16491605
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13088679
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09762133
45Acute myeloid leukemia_Homo sapiens_hsa052211.08227367
46Type I diabetes mellitus_Homo sapiens_hsa049401.05439563
47Dorso-ventral axis formation_Homo sapiens_hsa043201.04373458
48Hepatitis B_Homo sapiens_hsa051611.03668091
49Chemokine signaling pathway_Homo sapiens_hsa040621.03251552
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03048545
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.03009291
52Phagosome_Homo sapiens_hsa041451.01858891
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01698794
54Herpes simplex infection_Homo sapiens_hsa051681.01215517
55Protein digestion and absorption_Homo sapiens_hsa049741.01043442
56Protein export_Homo sapiens_hsa030600.98864770
57HTLV-I infection_Homo sapiens_hsa051660.96264341
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.95935217
59Renin secretion_Homo sapiens_hsa049240.95929214
60Pertussis_Homo sapiens_hsa051330.94435383
61FoxO signaling pathway_Homo sapiens_hsa040680.92107957
62MAPK signaling pathway_Homo sapiens_hsa040100.92012401
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.91243283
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90142920
65Type II diabetes mellitus_Homo sapiens_hsa049300.89541620
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89227754
67Bladder cancer_Homo sapiens_hsa052190.88629560
68Salmonella infection_Homo sapiens_hsa051320.88454848
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88338563
70Chronic myeloid leukemia_Homo sapiens_hsa052200.88120174
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86069823
72Allograft rejection_Homo sapiens_hsa053300.83052231
73Cocaine addiction_Homo sapiens_hsa050300.81403943
74Platelet activation_Homo sapiens_hsa046110.80658491
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.79477334
76African trypanosomiasis_Homo sapiens_hsa051430.75136384
77Shigellosis_Homo sapiens_hsa051310.73567806
78Epstein-Barr virus infection_Homo sapiens_hsa051690.73404356
79Insulin resistance_Homo sapiens_hsa049310.72496527
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.71680892
81Prostate cancer_Homo sapiens_hsa052150.71392646
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70500073
83Focal adhesion_Homo sapiens_hsa045100.69708390
84Notch signaling pathway_Homo sapiens_hsa043300.69685274
85Prion diseases_Homo sapiens_hsa050200.69245726
86Estrogen signaling pathway_Homo sapiens_hsa049150.68649642
87Hepatitis C_Homo sapiens_hsa051600.67665028
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67294692
89ECM-receptor interaction_Homo sapiens_hsa045120.67104801
90Small cell lung cancer_Homo sapiens_hsa052220.65911640
91Tuberculosis_Homo sapiens_hsa051520.65786923
92Pancreatic cancer_Homo sapiens_hsa052120.65387155
93Renal cell carcinoma_Homo sapiens_hsa052110.63796028
94Amoebiasis_Homo sapiens_hsa051460.61037129
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60647414
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.58717924
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58686941
98HIF-1 signaling pathway_Homo sapiens_hsa040660.56849467
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56734235
100beta-Alanine metabolism_Homo sapiens_hsa004100.55779519
101Autoimmune thyroid disease_Homo sapiens_hsa053200.55528661
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55392856
103VEGF signaling pathway_Homo sapiens_hsa043700.54088109
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52615318
105Salivary secretion_Homo sapiens_hsa049700.51599027
106Colorectal cancer_Homo sapiens_hsa052100.51518195
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50627733
108MicroRNAs in cancer_Homo sapiens_hsa052060.50549271
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50338505
110Staphylococcus aureus infection_Homo sapiens_hsa051500.49982835
111PPAR signaling pathway_Homo sapiens_hsa033200.48964661
112Pathways in cancer_Homo sapiens_hsa052000.48023167
113Adherens junction_Homo sapiens_hsa045200.47192661
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45185450
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44993515
116Endocytosis_Homo sapiens_hsa041440.44337776
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43551538
118Ovarian steroidogenesis_Homo sapiens_hsa049130.42195441
119GnRH signaling pathway_Homo sapiens_hsa049120.40655365
120Insulin secretion_Homo sapiens_hsa049110.40089887
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.39530688
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39206467
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38601892
124TGF-beta signaling pathway_Homo sapiens_hsa043500.38261136
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37376511
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37116294
127Viral carcinogenesis_Homo sapiens_hsa052030.36876619
128Proteoglycans in cancer_Homo sapiens_hsa052050.36197913
129Amphetamine addiction_Homo sapiens_hsa050310.35795024
130Sulfur metabolism_Homo sapiens_hsa009200.35089502
131p53 signaling pathway_Homo sapiens_hsa041150.34898686
132Galactose metabolism_Homo sapiens_hsa000520.34663251
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32679409
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32224324
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31094059

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