GEMIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)4.60751837
2maturation of SSU-rRNA (GO:0030490)4.42890452
3telomere maintenance via semi-conservative replication (GO:0032201)4.42429110
4ribosomal small subunit assembly (GO:0000028)4.40237184
5nucleobase biosynthetic process (GO:0046112)4.37673786
6DNA deamination (GO:0045006)4.32615169
7CENP-A containing nucleosome assembly (GO:0034080)4.30558520
8proteasome assembly (GO:0043248)4.30378008
9DNA strand elongation involved in DNA replication (GO:0006271)4.25765287
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.25090921
11rRNA modification (GO:0000154)4.22957702
12DNA replication initiation (GO:0006270)4.22849019
13chromatin remodeling at centromere (GO:0031055)4.17982204
14DNA replication checkpoint (GO:0000076)4.11255157
15DNA strand elongation (GO:0022616)4.10157000
16telomere maintenance via recombination (GO:0000722)4.10012075
17histone-serine phosphorylation (GO:0035404)4.03607254
18mitotic metaphase plate congression (GO:0007080)4.00749969
19ribosome biogenesis (GO:0042254)3.95557582
20mitotic recombination (GO:0006312)3.84148154
21ribosomal large subunit biogenesis (GO:0042273)3.81947637
22ATP synthesis coupled proton transport (GO:0015986)3.76514170
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76514170
24ribosome assembly (GO:0042255)3.74278582
25ribonucleoprotein complex biogenesis (GO:0022613)3.73352559
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.72832169
27telomere maintenance via telomere lengthening (GO:0010833)3.71187113
28kinetochore organization (GO:0051383)3.67355037
29termination of RNA polymerase III transcription (GO:0006386)3.65927093
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.65927093
31DNA replication-independent nucleosome assembly (GO:0006336)3.62714289
32DNA replication-independent nucleosome organization (GO:0034724)3.62714289
33protein neddylation (GO:0045116)3.61626666
347-methylguanosine mRNA capping (GO:0006370)3.58577841
35kinetochore assembly (GO:0051382)3.57770836
36formation of translation preinitiation complex (GO:0001731)3.57675846
37DNA double-strand break processing (GO:0000729)3.56385688
38rRNA methylation (GO:0031167)3.55993148
39transcription elongation from RNA polymerase I promoter (GO:0006362)3.55326423
407-methylguanosine RNA capping (GO:0009452)3.54626931
41RNA capping (GO:0036260)3.54626931
42cullin deneddylation (GO:0010388)3.54555718
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.53577748
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52917597
45termination of RNA polymerase I transcription (GO:0006363)3.52114531
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.50876882
47rRNA processing (GO:0006364)3.48915721
48transcription-coupled nucleotide-excision repair (GO:0006283)3.47542293
49positive regulation of histone H3-K4 methylation (GO:0051571)3.47016391
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46744401
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45997642
52* spliceosomal snRNP assembly (GO:0000387)3.45918955
53neuron fate determination (GO:0048664)3.45498037
54metaphase plate congression (GO:0051310)3.45124460
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44599243
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44170479
57respiratory chain complex IV assembly (GO:0008535)3.42113293
58viral mRNA export from host cell nucleus (GO:0046784)3.42073786
59histone exchange (GO:0043486)3.40621824
60transcription from RNA polymerase I promoter (GO:0006360)3.37466190
61rRNA metabolic process (GO:0016072)3.36650488
62regulation of double-strand break repair via homologous recombination (GO:0010569)3.32165103
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.29271400
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.25344882
65maturation of 5.8S rRNA (GO:0000460)3.24197054
66negative regulation of DNA-dependent DNA replication (GO:2000104)3.23609056
67protein deneddylation (GO:0000338)3.23246887
68protein complex biogenesis (GO:0070271)3.21476318
69replication fork processing (GO:0031297)3.20671356
70pseudouridine synthesis (GO:0001522)3.20043206
71ribosomal small subunit biogenesis (GO:0042274)3.18948799
72protein localization to kinetochore (GO:0034501)3.18244914
73meiotic chromosome segregation (GO:0045132)3.17239510
74regulation of mitotic spindle checkpoint (GO:1903504)3.16169980
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16169980
76negative regulation of ligase activity (GO:0051352)3.16161734
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16161734
78attachment of spindle microtubules to kinetochore (GO:0008608)3.13793922
79mitochondrial respiratory chain complex assembly (GO:0033108)3.13751561
80cell fate commitment involved in formation of primary germ layer (GO:0060795)3.12816927
81chaperone-mediated protein transport (GO:0072321)3.12000691
82respiratory electron transport chain (GO:0022904)3.10369674
83protein K6-linked ubiquitination (GO:0085020)3.10296708
84DNA-dependent DNA replication (GO:0006261)3.10230427
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09442123
86mitochondrial respiratory chain complex I assembly (GO:0032981)3.09442123
87NADH dehydrogenase complex assembly (GO:0010257)3.09442123
88cytochrome complex assembly (GO:0017004)3.09370383
89tRNA methylation (GO:0030488)3.09212950
90transcription initiation from RNA polymerase I promoter (GO:0006361)3.08890528
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08482337
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08482337
93signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07864283
94signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07864283
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07864283
96IMP biosynthetic process (GO:0006188)3.06903835
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06294750
98cell cycle G1/S phase transition (GO:0044843)3.05061341
99G1/S transition of mitotic cell cycle (GO:0000082)3.05061341
100electron transport chain (GO:0022900)3.04732459
101cellular component biogenesis (GO:0044085)3.03544119
102intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02262150
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02262150
104establishment of chromosome localization (GO:0051303)3.00326547
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.00140422
106signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00140422
107deoxyribonucleotide biosynthetic process (GO:0009263)2.99679350
108regulation of centrosome cycle (GO:0046605)2.98432602
109regulation of spindle checkpoint (GO:0090231)2.98245245
110signal transduction involved in cell cycle checkpoint (GO:0072395)2.98076579
111telomere maintenance (GO:0000723)2.96156140
112telomere organization (GO:0032200)2.96104783
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95783957
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94928489
115regulation of cellular amino acid metabolic process (GO:0006521)2.94130901
116translational termination (GO:0006415)2.92236825
117viral transcription (GO:0019083)2.90526923
118DNA replication-dependent nucleosome organization (GO:0034723)2.89900830
119regulation of spindle organization (GO:0090224)2.89728908
120DNA catabolic process, exonucleolytic (GO:0000738)2.88553561
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88546865
122pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.87893963
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87753191
124reciprocal meiotic recombination (GO:0007131)2.87418711
125reciprocal DNA recombination (GO:0035825)2.87418711
126mismatch repair (GO:0006298)2.85627835
127spindle checkpoint (GO:0031577)2.85378025
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85181751
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.85181751
130water-soluble vitamin biosynthetic process (GO:0042364)2.85104516
131transcription elongation from RNA polymerase II promoter (GO:0006368)2.83855221
132positive regulation of ligase activity (GO:0051351)2.83471145
133ncRNA processing (GO:0034470)2.82902687
134regulation of mitochondrial translation (GO:0070129)2.81999118
135translational initiation (GO:0006413)2.81922848
136DNA replication-dependent nucleosome assembly (GO:0006335)2.80593588
137single strand break repair (GO:0000012)2.79218634
138spinal cord motor neuron differentiation (GO:0021522)2.77015633
139regulation of DNA endoreduplication (GO:0032875)2.76871475
140DNA ligation (GO:0006266)2.75945546
141protein localization to microtubule cytoskeleton (GO:0072698)2.73829963
142synapsis (GO:0007129)2.72597128
143negative regulation of chromosome segregation (GO:0051985)2.71891187
144regulation of helicase activity (GO:0051095)2.69300148
145prenylation (GO:0097354)2.68417627
146protein prenylation (GO:0018342)2.68417627
147negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67248985
148negative regulation of mitotic sister chromatid separation (GO:2000816)2.67248985
149negative regulation of sister chromatid segregation (GO:0033046)2.67248985
150negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.67248985
151negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.67248985
152recombinational repair (GO:0000725)2.66918104
153mitotic spindle checkpoint (GO:0071174)2.64413804
154double-strand break repair via homologous recombination (GO:0000724)2.63609230
155postreplication repair (GO:0006301)2.61786132
156DNA damage response, detection of DNA damage (GO:0042769)2.61164452
157regulation of meiosis I (GO:0060631)2.59277383
158mitotic spindle assembly checkpoint (GO:0007094)2.56111067
159DNA strand renaturation (GO:0000733)2.55645240
160regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54686240
161regulation of mitotic metaphase/anaphase transition (GO:0030071)2.54686240
162spindle assembly checkpoint (GO:0071173)2.53774045
163resolution of meiotic recombination intermediates (GO:0000712)2.52626009
164acrosome reaction (GO:0007340)2.51507480
165regulation of cell maturation (GO:1903429)2.50397619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.99929171
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24400451
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.15039306
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52954939
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.51301620
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.45429121
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.42003448
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27925268
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.09122232
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02480596
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.00353004
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99831220
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99293963
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90753932
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89690080
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84111310
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82161662
18ZNF274_21170338_ChIP-Seq_K562_Hela2.74743457
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70421401
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56075147
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55019475
22VDR_23849224_ChIP-Seq_CD4+_Human2.53568833
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49381182
24VDR_22108803_ChIP-Seq_LS180_Human2.45684363
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42460472
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.27057602
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26979322
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25293962
29FOXP3_21729870_ChIP-Seq_TREG_Human2.23048015
30EWS_26573619_Chip-Seq_HEK293_Human2.16430642
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14802640
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13652517
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12170021
34XRN2_22483619_ChIP-Seq_HELA_Human2.10898561
35DCP1A_22483619_ChIP-Seq_HELA_Human2.06454764
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05498023
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04759442
38SRF_21415370_ChIP-Seq_HL-1_Mouse2.04603343
39FUS_26573619_Chip-Seq_HEK293_Human2.03076150
40ELK1_19687146_ChIP-ChIP_HELA_Human1.96741384
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95971488
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91534957
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91015423
44TAF15_26573619_Chip-Seq_HEK293_Human1.89676332
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.87198253
46GABP_19822575_ChIP-Seq_HepG2_Human1.87136188
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84968205
48TTF2_22483619_ChIP-Seq_HELA_Human1.84595764
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81761030
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80567352
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.78757021
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78600419
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78521352
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77639104
55AR_21909140_ChIP-Seq_LNCAP_Human1.77302441
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75123713
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71339040
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69780806
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64413292
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.62833451
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62548794
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.62212185
63P300_19829295_ChIP-Seq_ESCs_Human1.57894051
64IGF1R_20145208_ChIP-Seq_DFB_Human1.55029252
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52644485
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51462633
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48234093
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43716936
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43428792
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42915925
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41883109
72GBX2_23144817_ChIP-Seq_PC3_Human1.38805347
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37442366
74CIITA_25753668_ChIP-Seq_RAJI_Human1.37260728
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35569813
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.34159180
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32246904
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.30945491
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29844488
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25819950
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.24309821
82EZH2_22144423_ChIP-Seq_EOC_Human1.24016395
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23752652
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23723257
85TP53_22573176_ChIP-Seq_HFKS_Human1.17611095
86KDM5A_27292631_Chip-Seq_BREAST_Human1.16571242
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16016231
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15514991
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14652128
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14535367
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13442326
92MYC_18940864_ChIP-ChIP_HL60_Human1.11490773
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10967122
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10956911
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09009002
96CBP_20019798_ChIP-Seq_JUKART_Human1.09006556
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09006556
98IRF1_19129219_ChIP-ChIP_H3396_Human1.08828760
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08607348
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07252705
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05672014
102NANOG_19829295_ChIP-Seq_ESCs_Human1.05152846
103SOX2_19829295_ChIP-Seq_ESCs_Human1.05152846
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05104774
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02682404
106ELK1_22589737_ChIP-Seq_MCF10A_Human1.01719061
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01441612
108RNF2_27304074_Chip-Seq_NSC_Mouse1.01391396
109CBX2_27304074_Chip-Seq_ESCs_Mouse0.98063681
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97080958
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97065291
112FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96577933
113FOXA1_25329375_ChIP-Seq_VCAP_Human0.96577933
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96394467
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95973606
116BCAT_22108803_ChIP-Seq_LS180_Human0.94883274
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94492216
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.94409896
119SPI1_23547873_ChIP-Seq_NB4_Human0.94026092
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91873466
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91825572
122TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90956277
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90247088
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88370391
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88062596
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85650772
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.84111356
128ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84093213
129KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81310640
130TFEB_21752829_ChIP-Seq_HELA_Human0.79914079
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79610463
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79127442
133NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78033870
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76492507
135CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76470028
136IRF8_21731497_ChIP-ChIP_J774_Mouse0.75816676
137KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.72990205
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.72990205
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.72990205
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.69600651
141POU5F1_16153702_ChIP-ChIP_HESCs_Human0.68302636
142EGR1_19374776_ChIP-ChIP_THP-1_Human0.67674905
143EGR1_23403033_ChIP-Seq_LIVER_Mouse0.65826988
144FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64940589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.53359168
2MP0010094_abnormal_chromosome_stability4.40862685
3MP0003111_abnormal_nucleus_morphology4.35052901
4MP0008058_abnormal_DNA_repair4.14118002
5MP0008057_abnormal_DNA_replication3.96554459
6MP0004957_abnormal_blastocyst_morpholog3.59523738
7MP0003077_abnormal_cell_cycle3.53291596
8MP0003718_maternal_effect2.82166566
9MP0003786_premature_aging2.73631357
10MP0008007_abnormal_cellular_replicative2.67678937
11MP0003787_abnormal_imprinting2.65446925
12MP0002396_abnormal_hematopoietic_system2.38086146
13MP0008932_abnormal_embryonic_tissue2.37293716
14MP0006292_abnormal_olfactory_placode2.35736146
15MP0002132_abnormal_respiratory_system2.28681302
16MP0006072_abnormal_retinal_apoptosis2.20122226
17MP0008789_abnormal_olfactory_epithelium2.14595289
18MP0003195_calcinosis2.04815622
19MP0003880_abnormal_central_pattern2.04553697
20MP0001529_abnormal_vocalization1.93904687
21MP0008260_abnormal_autophagy1.93606004
22MP0009697_abnormal_copulation1.89557643
23MP0003122_maternal_imprinting1.81099050
24MP0005499_abnormal_olfactory_system1.80441391
25MP0005394_taste/olfaction_phenotype1.80441391
26MP0002736_abnormal_nociception_after1.77058052
27MP0006276_abnormal_autonomic_nervous1.73569290
28MP0001968_abnormal_touch/_nociception1.69111308
29MP0003186_abnormal_redox_activity1.66501539
30MP0003941_abnormal_skin_development1.60596835
31MP0005551_abnormal_eye_electrophysiolog1.59765454
32MP0003123_paternal_imprinting1.59530616
33MP0008877_abnormal_DNA_methylation1.57636095
34MP0000350_abnormal_cell_proliferation1.54563195
35MP0009333_abnormal_splenocyte_physiolog1.54397745
36MP0005075_abnormal_melanosome_morpholog1.49626235
37MP0003806_abnormal_nucleotide_metabolis1.49160937
38MP0004133_heterotaxia1.47051600
39MP0003937_abnormal_limbs/digits/tail_de1.46289904
40MP0005253_abnormal_eye_physiology1.44224828
41MP0000490_abnormal_crypts_of1.43518520
42MP0003136_yellow_coat_color1.42800543
43MP0001730_embryonic_growth_arrest1.40990801
44MP0002277_abnormal_respiratory_mucosa1.35952713
45MP0002751_abnormal_autonomic_nervous1.32867463
46MP0003315_abnormal_perineum_morphology1.32836052
47MP0001764_abnormal_homeostasis1.29827089
48MP0000631_abnormal_neuroendocrine_gland1.29255952
49MP0002163_abnormal_gland_morphology1.28325288
50MP0009379_abnormal_foot_pigmentation1.27896071
51MP0002735_abnormal_chemical_nociception1.27636961
52MP0003763_abnormal_thymus_physiology1.27236763
53MP0002210_abnormal_sex_determination1.26746117
54MP0003119_abnormal_digestive_system1.25976512
55MP0000049_abnormal_middle_ear1.24488977
56MP0002160_abnormal_reproductive_system1.24057630
57MP0000313_abnormal_cell_death1.22812263
58MP0002822_catalepsy1.21270596
59MP0002102_abnormal_ear_morphology1.20639886
60MP0001986_abnormal_taste_sensitivity1.19759511
61MP0001835_abnormal_antigen_presentation1.19291657
62MP0005389_reproductive_system_phenotype1.17107034
63MP0002019_abnormal_tumor_incidence1.16245751
64MP0004142_abnormal_muscle_tone1.15284558
65MP0005645_abnormal_hypothalamus_physiol1.15160811
66MP0005671_abnormal_response_to1.14548661
67MP0002095_abnormal_skin_pigmentation1.12878097
68MP0005646_abnormal_pituitary_gland1.12537564
69MP0000566_synostosis1.12129232
70MP0000015_abnormal_ear_pigmentation1.11734627
71MP0003011_delayed_dark_adaptation1.10714803
72MP0001485_abnormal_pinna_reflex1.10321933
73MP0005380_embryogenesis_phenotype1.09110784
74MP0001672_abnormal_embryogenesis/_devel1.09110784
75MP0004147_increased_porphyrin_level1.08871332
76MP0002837_dystrophic_cardiac_calcinosis1.07563935
77MP0002233_abnormal_nose_morphology1.06541908
78MP0001119_abnormal_female_reproductive1.06097580
79MP0001286_abnormal_eye_development1.05935738
80MP0010307_abnormal_tumor_latency1.05177035
81MP0004381_abnormal_hair_follicle1.04541873
82MP0001188_hyperpigmentation1.03664384
83MP0009785_altered_susceptibility_to1.03171559
84MP0003698_abnormal_male_reproductive1.02983859
85MP0001919_abnormal_reproductive_system1.02906078
86MP0001145_abnormal_male_reproductive1.02257847
87MP0004782_abnormal_surfactant_physiolog1.02113012
88MP0002398_abnormal_bone_marrow1.01621798
89MP0001697_abnormal_embryo_size1.01008643
90MP0002234_abnormal_pharynx_morphology1.00842096
91MP0001324_abnormal_eye_pigmentation1.00440091
92MP0002722_abnormal_immune_system0.99721984
93MP0000647_abnormal_sebaceous_gland0.99681497
94MP0005084_abnormal_gallbladder_morpholo0.98552413
95MP0002080_prenatal_lethality0.97701952
96MP0000689_abnormal_spleen_morphology0.97058757
97MP0002638_abnormal_pupillary_reflex0.97029197
98MP0001984_abnormal_olfaction0.96475820
99MP0006036_abnormal_mitochondrial_physio0.94929057
100MP0004808_abnormal_hematopoietic_stem0.93454852
101MP0000653_abnormal_sex_gland0.93266956
102MP0000383_abnormal_hair_follicle0.92397018
103MP0005195_abnormal_posterior_eye0.91358676
104MP0005174_abnormal_tail_pigmentation0.91149074
105MP0003890_abnormal_embryonic-extraembry0.90874928
106MP0009780_abnormal_chondrocyte_physiolo0.90509647
107MP0000703_abnormal_thymus_morphology0.89453003
108MP0001929_abnormal_gametogenesis0.89184081
109MP0002938_white_spotting0.89045127
110MP0002429_abnormal_blood_cell0.87300711
111MP0008995_early_reproductive_senescence0.87085818
112MP0005397_hematopoietic_system_phenotyp0.86795071
113MP0001545_abnormal_hematopoietic_system0.86795071
114MP0003567_abnormal_fetal_cardiomyocyte0.86620148
115MP0005395_other_phenotype0.86483075
116MP0003755_abnormal_palate_morphology0.86312644
117MP0008872_abnormal_physiological_respon0.85469716
118MP0006035_abnormal_mitochondrial_morpho0.85396928
119MP0003984_embryonic_growth_retardation0.83985715
120MP0005391_vision/eye_phenotype0.83885375
121MP0002111_abnormal_tail_morphology0.82270639
122MP0001853_heart_inflammation0.81364571
123MP0002088_abnormal_embryonic_growth/wei0.81339917
124MP0001293_anophthalmia0.81238437
125MP0000716_abnormal_immune_system0.80361593
126MP0002148_abnormal_hypersensitivity_rea0.80087345
127MP0005386_behavior/neurological_phenoty0.79749952
128MP0004924_abnormal_behavior0.79749952
129MP0005410_abnormal_fertilization0.79560829
130MP0002282_abnormal_trachea_morphology0.79410180
131MP0001800_abnormal_humoral_immune0.79322029
132MP0009046_muscle_twitch0.78296601
133MP0004885_abnormal_endolymph0.77954422
134MP0003121_genomic_imprinting0.77918271
135MP0000778_abnormal_nervous_system0.77682464
136MP0005408_hypopigmentation0.77678674
137MP0003724_increased_susceptibility_to0.77297164
138MP0002752_abnormal_somatic_nervous0.76611438
139MP0005451_abnormal_body_composition0.75442188
140MP0003137_abnormal_impulse_conducting0.74983188
141MP0000569_abnormal_digit_pigmentation0.74211081
142MP0002085_abnormal_embryonic_tissue0.74051327
143MP0002086_abnormal_extraembryonic_tissu0.73749107
144MP0001186_pigmentation_phenotype0.72809164
145MP0002420_abnormal_adaptive_immunity0.72485202
146MP0009250_abnormal_appendicular_skeleto0.72276095
147MP0002272_abnormal_nervous_system0.72052130
148MP0001819_abnormal_immune_cell0.71964379
149MP0002723_abnormal_immune_serum0.71832727
150MP0002254_reproductive_system_inflammat0.70834900
151MP0002697_abnormal_eye_size0.70578735
152MP0002084_abnormal_developmental_patter0.70538595
153MP0001542_abnormal_bone_strength0.70272072
154MP0003938_abnormal_ear_development0.69930209
155MP0002452_abnormal_antigen_presenting0.69758864
156MP0005025_abnormal_response_to0.69321559
157MP0000372_irregular_coat_pigmentation0.67787313
158MP0000371_diluted_coat_color0.64904291
159MP0005379_endocrine/exocrine_gland_phen0.63992612

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.21976747
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.07485796
3Chromsome breakage (HP:0040012)4.92073838
4Breast hypoplasia (HP:0003187)4.31080282
5Volvulus (HP:0002580)4.03349657
6Reticulocytopenia (HP:0001896)4.01597450
7Acute necrotizing encephalopathy (HP:0006965)3.92578996
8Abnormality of the preputium (HP:0100587)3.63393092
9Meckel diverticulum (HP:0002245)3.52006107
10Acute encephalopathy (HP:0006846)3.49515632
11Abnormal mitochondria in muscle tissue (HP:0008316)3.41255090
12Abnormality of chromosome stability (HP:0003220)3.41149081
13Abnormality of the ileum (HP:0001549)3.40988420
14Abnormality of cells of the erythroid lineage (HP:0012130)3.39394374
15Aplastic anemia (HP:0001915)3.39163430
16Abnormal number of erythroid precursors (HP:0012131)3.36945583
17Rough bone trabeculation (HP:0100670)3.36792354
18True hermaphroditism (HP:0010459)3.35894748
19Progressive macrocephaly (HP:0004481)3.29090155
20Oral leukoplakia (HP:0002745)3.28676146
21Mitochondrial inheritance (HP:0001427)3.25312527
22Duplicated collecting system (HP:0000081)3.16378185
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.14388608
24Increased CSF lactate (HP:0002490)3.10965377
25Patellar aplasia (HP:0006443)3.10387695
26Abnormality of midbrain morphology (HP:0002418)2.99304837
27Molar tooth sign on MRI (HP:0002419)2.99304837
28Aplasia/Hypoplasia of the patella (HP:0006498)2.99066848
29Bone marrow hypocellularity (HP:0005528)2.83722009
30Abnormality of the renal collecting system (HP:0004742)2.81190567
31Absent thumb (HP:0009777)2.80636877
32Cerebral edema (HP:0002181)2.79662313
33Carpal bone hypoplasia (HP:0001498)2.77172564
34Cerebral hypomyelination (HP:0006808)2.75357364
35Impulsivity (HP:0100710)2.75037937
36Increased hepatocellular lipid droplets (HP:0006565)2.73256635
37Small intestinal stenosis (HP:0012848)2.63669010
38Duodenal stenosis (HP:0100867)2.63669010
39Hepatocellular necrosis (HP:0001404)2.63247300
40Macrocytic anemia (HP:0001972)2.61646425
41Type I transferrin isoform profile (HP:0003642)2.61395607
42Optic disc pallor (HP:0000543)2.61329251
43Hepatic necrosis (HP:0002605)2.59257942
44Clubbing of toes (HP:0100760)2.56429112
45Abnormality of pyrimidine metabolism (HP:0004353)2.55104508
46Absent radius (HP:0003974)2.53580234
47Abnormal trabecular bone morphology (HP:0100671)2.53544593
48Pancytopenia (HP:0001876)2.53338369
49Hyperglycinuria (HP:0003108)2.52381601
50Nephronophthisis (HP:0000090)2.51872232
51Lipid accumulation in hepatocytes (HP:0006561)2.51338751
52Microvesicular hepatic steatosis (HP:0001414)2.47115298
53Medial flaring of the eyebrow (HP:0010747)2.47075332
54Ureteral duplication (HP:0000073)2.43089685
55Premature graying of hair (HP:0002216)2.41821077
56Myelodysplasia (HP:0002863)2.40436633
57Pallor (HP:0000980)2.39622940
58Abnormality of DNA repair (HP:0003254)2.39355554
59Constricted visual fields (HP:0001133)2.37821750
60Ectopic kidney (HP:0000086)2.32366580
61Absent forearm bone (HP:0003953)2.30852686
62Aplasia involving forearm bones (HP:0009822)2.30852686
633-Methylglutaconic aciduria (HP:0003535)2.30832197
64Triphalangeal thumb (HP:0001199)2.29646771
65Septo-optic dysplasia (HP:0100842)2.29304267
66Hyperglycinemia (HP:0002154)2.28956502
67Colon cancer (HP:0003003)2.25293747
68Congenital, generalized hypertrichosis (HP:0004540)2.21605502
69Sparse eyelashes (HP:0000653)2.21532995
70Degeneration of anterior horn cells (HP:0002398)2.21282284
71Abnormality of the anterior horn cell (HP:0006802)2.21282284
72Sclerocornea (HP:0000647)2.21193138
73Reduced antithrombin III activity (HP:0001976)2.20218260
74Abnormality of glycine metabolism (HP:0010895)2.20047115
75Abnormality of serine family amino acid metabolism (HP:0010894)2.20047115
76Horseshoe kidney (HP:0000085)2.18664095
77Dry hair (HP:0011359)2.15768001
78Increased serum lactate (HP:0002151)2.15615980
79Abnormality of the heme biosynthetic pathway (HP:0010472)2.15351781
80Intestinal atresia (HP:0011100)2.14669445
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.14158118
82Methylmalonic acidemia (HP:0002912)2.12753890
83Abnormality of the duodenum (HP:0002246)2.12652015
84Agnosia (HP:0010524)2.12584952
85Medulloblastoma (HP:0002885)2.07924291
86Abnormality of alanine metabolism (HP:0010916)2.07278558
87Hyperalaninemia (HP:0003348)2.07278558
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07278558
89Sloping forehead (HP:0000340)2.06124200
90Renal cortical cysts (HP:0000803)2.04788797
91Megaloblastic anemia (HP:0001889)2.04426148
92Cellular immunodeficiency (HP:0005374)2.04065375
93Prostate neoplasm (HP:0100787)2.03958995
94Lymphoma (HP:0002665)2.03098394
95Rhabdomyosarcoma (HP:0002859)2.01333518
96Optic nerve hypoplasia (HP:0000609)2.01020969
97Secondary amenorrhea (HP:0000869)2.00075900
98Nephroblastoma (Wilms tumor) (HP:0002667)1.98717675
99Congenital primary aphakia (HP:0007707)1.97361996
100Anencephaly (HP:0002323)1.97028815
101Abnormal spermatogenesis (HP:0008669)1.96198646
102Abnormal lung lobation (HP:0002101)1.95616676
103Cleft eyelid (HP:0000625)1.95459498
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95328052
105Renal Fanconi syndrome (HP:0001994)1.94991448
106Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94668725
107Abnormality of the renal medulla (HP:0100957)1.94481563
108Pendular nystagmus (HP:0012043)1.94352229
109Pancreatic fibrosis (HP:0100732)1.93723192
110Abnormality of methionine metabolism (HP:0010901)1.93682881
111Gait imbalance (HP:0002141)1.93504940
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93125369
113Tracheoesophageal fistula (HP:0002575)1.92962297
114Abnormality of the carotid arteries (HP:0005344)1.92535173
115Abnormality of the renal cortex (HP:0011035)1.92442000
116Type 2 muscle fiber atrophy (HP:0003554)1.91741551
117Supernumerary spleens (HP:0009799)1.90570473
11811 pairs of ribs (HP:0000878)1.90524771
119Prolonged neonatal jaundice (HP:0006579)1.90447742
120Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90414722
121Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90414722
122Lissencephaly (HP:0001339)1.89746229
123IgG deficiency (HP:0004315)1.88654993
124Lactic acidosis (HP:0003128)1.88458851
125Microretrognathia (HP:0000308)1.88138718
126Pancreatic cysts (HP:0001737)1.87902947
127Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87758263
128Abolished electroretinogram (ERG) (HP:0000550)1.87573229
129Embryonal renal neoplasm (HP:0011794)1.86945837
130Premature ovarian failure (HP:0008209)1.86620820
131Postaxial foot polydactyly (HP:0001830)1.84529514
132Hypoplasia of the pons (HP:0012110)1.82762407
133Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82698659
134Abnormality of the labia minora (HP:0012880)1.82115907
135Leukodystrophy (HP:0002415)1.81012994
136Neoplasm of the pancreas (HP:0002894)1.80997767
137Nephrogenic diabetes insipidus (HP:0009806)1.80953950
138Asplenia (HP:0001746)1.80950565
139Methylmalonic aciduria (HP:0012120)1.80397414
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79241862
141IgM deficiency (HP:0002850)1.79072097
142Short thumb (HP:0009778)1.78871788
143Muscle fiber atrophy (HP:0100295)1.78635788
144Male pseudohermaphroditism (HP:0000037)1.78092136
145Genital tract atresia (HP:0001827)1.77507855
146Hypergonadotropic hypogonadism (HP:0000815)1.77402903
147Preaxial hand polydactyly (HP:0001177)1.77330122
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75937987
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75394326
150Cystic liver disease (HP:0006706)1.75035460
151Long clavicles (HP:0000890)1.74882335
152Abnormal protein glycosylation (HP:0012346)1.74341050
153Abnormal glycosylation (HP:0012345)1.74341050
154Abnormal protein N-linked glycosylation (HP:0012347)1.74341050
155Glycosuria (HP:0003076)1.73624652
156Abnormality of urine glucose concentration (HP:0011016)1.73624652
157Respiratory failure (HP:0002878)1.73348507
158Abnormality of the pons (HP:0007361)1.73203274
159Abnormality of serum amino acid levels (HP:0003112)1.72872524
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.71841980
161Bony spicule pigmentary retinopathy (HP:0007737)1.71534406
162Vaginal atresia (HP:0000148)1.71139454
163Generalized aminoaciduria (HP:0002909)1.67969143
164Dandy-Walker malformation (HP:0001305)1.67483912
165Lethargy (HP:0001254)1.67377182
166Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.67047787
167Short 1st metacarpal (HP:0010034)1.67047787
168Bifid tongue (HP:0010297)1.66683687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.10366949
2STK164.39058739
3BUB14.37183671
4WEE13.65057339
5TAF13.49659419
6EIF2AK13.12635853
7VRK23.12003229
8MARK12.83560134
9SRPK12.72177124
10PLK42.59280119
11CASK2.57075916
12ZAK2.48549271
13NME22.42475121
14MKNK22.39926801
15WNK32.30097975
16EIF2AK32.25769684
17MKNK12.23578850
18ACVR1B2.23060817
19TSSK62.22448396
20IRAK32.21247948
21CDC72.18936960
22PNCK2.14450969
23BRSK22.06462406
24VRK12.02494763
25NEK21.92390976
26TTK1.82673670
27PLK11.79342864
28TNIK1.76887715
29EIF2AK21.74381759
30CCNB11.73797674
31FRK1.71396575
32TRIM281.68196016
33AKT31.66895556
34PLK31.66740631
35MAP4K21.65030510
36ATR1.44663221
37DYRK31.42968604
38AURKB1.40823155
39BRSK11.37045520
40CHEK21.35820539
41IRAK41.29497273
42CDK71.29026288
43RPS6KA41.25656508
44TLK11.22799267
45TXK1.19094423
46AURKA1.15149290
47PBK1.14884897
48INSRR1.14091216
49EPHA21.12137045
50PIM21.08899519
51OXSR11.08314597
52PASK1.07224863
53CSNK1G11.06540576
54CSNK1G31.00659985
55NEK11.00446713
56MST40.98179315
57CSNK1G20.97290718
58STK390.96354086
59CDK80.93713258
60WNK40.92607093
61STK40.91191205
62NME10.90666029
63CHEK10.86057031
64CDK190.83679308
65RPS6KB20.82401854
66TGFBR10.82125411
67STK38L0.81613960
68MAPK130.81556232
69CSNK1A1L0.81318836
70BCR0.81065769
71BLK0.80595366
72CSNK2A10.79997510
73ARAF0.78773807
74TEC0.78281555
75PLK20.78187368
76BRD40.76783215
77BRAF0.75516411
78CDK40.75311381
79MAP3K40.73414390
80YES10.73265843
81TIE10.72342913
82MAP3K140.71852509
83IKBKB0.70515896
84PIM10.70275761
85PINK10.69807196
86BMPR1B0.69381790
87RPS6KA50.68281522
88NUAK10.65664477
89GRK10.65115333
90PRKCG0.64900422
91CSNK2A20.63984006
92ATM0.63547844
93CLK10.62929033
94TAOK20.62919067
95NTRK20.61658010
96NEK90.60623808
97MAP2K70.60040505
98MAP3K80.59876478
99KDR0.59766455
100NEK60.59412343
101CDK30.59240681
102BCKDK0.54203207
103CDK20.51139698
104DYRK20.49584405
105MUSK0.48388662
106ADRBK20.48146429
107BTK0.43545286
108PRKCI0.43369020
109CSNK1E0.43299632
110MINK10.43182810
111CDK10.42742624
112LYN0.42027205
113CDK90.41327528
114PAK30.40900941
115MAPKAPK50.40144851
116MELK0.40097186
117STK100.39393781
118NLK0.36205398
119TYK20.35884151
120PDK20.34552851
121MAP4K10.34022281
122PIK3CG0.32635910
123RPS6KB10.32227893
124TESK20.31792908
125BMPR20.30988494
126CHUK0.30631419
127PRKCE0.30424515
128MAP3K30.30423826
129ERBB40.30294446
130ERBB30.29711575
131MAP3K120.29201090
132STK30.28932562
133IRAK10.26873937
134PRKDC0.25769154
135PAK10.25756114
136ADRBK10.25027480
137OBSCN0.24875905
138PRKACB0.24745187
139KIT0.24648332
140STK240.24119501
141DAPK10.23663577
142ABL20.22723385
143ZAP700.22538536

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.26046110
2Proteasome_Homo sapiens_hsa030503.77552238
3Mismatch repair_Homo sapiens_hsa034303.72409259
4RNA polymerase_Homo sapiens_hsa030203.69892153
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53966759
6Ribosome_Homo sapiens_hsa030103.40459965
7Homologous recombination_Homo sapiens_hsa034403.10375306
8Base excision repair_Homo sapiens_hsa034102.92296974
9Spliceosome_Homo sapiens_hsa030402.83585876
10Nucleotide excision repair_Homo sapiens_hsa034202.75681290
11Pyrimidine metabolism_Homo sapiens_hsa002402.73794145
12Fanconi anemia pathway_Homo sapiens_hsa034602.58357258
13* RNA transport_Homo sapiens_hsa030132.56791776
14One carbon pool by folate_Homo sapiens_hsa006702.35061196
15Vitamin B6 metabolism_Homo sapiens_hsa007502.32107373
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28387407
17Basal transcription factors_Homo sapiens_hsa030222.19659464
18Cell cycle_Homo sapiens_hsa041102.15422653
19Non-homologous end-joining_Homo sapiens_hsa034502.02291692
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99752402
21Propanoate metabolism_Homo sapiens_hsa006401.89003404
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82960349
23RNA degradation_Homo sapiens_hsa030181.68882567
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.67367850
25Purine metabolism_Homo sapiens_hsa002301.62041268
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58547047
27Folate biosynthesis_Homo sapiens_hsa007901.48796850
28Butanoate metabolism_Homo sapiens_hsa006501.47559934
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43767447
30p53 signaling pathway_Homo sapiens_hsa041151.33222990
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.30357272
32Protein export_Homo sapiens_hsa030601.25365717
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23737677
34Steroid biosynthesis_Homo sapiens_hsa001001.22231854
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20686688
36Cardiac muscle contraction_Homo sapiens_hsa042601.19965837
37mRNA surveillance pathway_Homo sapiens_hsa030151.16186939
38Pyruvate metabolism_Homo sapiens_hsa006201.14704812
39Epstein-Barr virus infection_Homo sapiens_hsa051691.03975870
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03065365
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00680874
42Tryptophan metabolism_Homo sapiens_hsa003800.99303773
43Nicotine addiction_Homo sapiens_hsa050330.93712600
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90526826
45Pentose phosphate pathway_Homo sapiens_hsa000300.89332385
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87526946
47Regulation of autophagy_Homo sapiens_hsa041400.87155349
48Nitrogen metabolism_Homo sapiens_hsa009100.85286502
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84997756
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.84552791
51Herpes simplex infection_Homo sapiens_hsa051680.83884242
52Fatty acid elongation_Homo sapiens_hsa000620.82188598
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80514834
54Primary immunodeficiency_Homo sapiens_hsa053400.78985577
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78634834
56Huntingtons disease_Homo sapiens_hsa050160.78217090
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77653211
58Glutathione metabolism_Homo sapiens_hsa004800.75895019
59Taste transduction_Homo sapiens_hsa047420.73565839
60Oxidative phosphorylation_Homo sapiens_hsa001900.70862597
61Parkinsons disease_Homo sapiens_hsa050120.70555838
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.70287115
63Caffeine metabolism_Homo sapiens_hsa002320.69875530
64Systemic lupus erythematosus_Homo sapiens_hsa053220.67944683
65Sulfur relay system_Homo sapiens_hsa041220.66460568
66Antigen processing and presentation_Homo sapiens_hsa046120.65216781
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.65126068
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64826830
69Basal cell carcinoma_Homo sapiens_hsa052170.63900297
70Arachidonic acid metabolism_Homo sapiens_hsa005900.63236366
71Vitamin digestion and absorption_Homo sapiens_hsa049770.59158666
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59117317
73Olfactory transduction_Homo sapiens_hsa047400.58458702
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54012002
75Metabolic pathways_Homo sapiens_hsa011000.52911990
76Selenocompound metabolism_Homo sapiens_hsa004500.52242148
77Hedgehog signaling pathway_Homo sapiens_hsa043400.51531828
78Measles_Homo sapiens_hsa051620.51327412
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.51299516
80Biosynthesis of amino acids_Homo sapiens_hsa012300.51071590
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.50925719
82Fatty acid degradation_Homo sapiens_hsa000710.49855843
83Autoimmune thyroid disease_Homo sapiens_hsa053200.48885135
84Graft-versus-host disease_Homo sapiens_hsa053320.48579057
85Legionellosis_Homo sapiens_hsa051340.48021498
86Collecting duct acid secretion_Homo sapiens_hsa049660.47176304
87Allograft rejection_Homo sapiens_hsa053300.45331763
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44158404
89Fatty acid metabolism_Homo sapiens_hsa012120.43556254
90Arginine and proline metabolism_Homo sapiens_hsa003300.40041906
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39321005
92Sulfur metabolism_Homo sapiens_hsa009200.38859749
93Oocyte meiosis_Homo sapiens_hsa041140.38823636
94Viral carcinogenesis_Homo sapiens_hsa052030.37905903
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37795465
96TGF-beta signaling pathway_Homo sapiens_hsa043500.36129744
97Galactose metabolism_Homo sapiens_hsa000520.35714943
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35102582
99Ether lipid metabolism_Homo sapiens_hsa005650.34998684
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34757993
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33866255
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33807820
103Hematopoietic cell lineage_Homo sapiens_hsa046400.32616659
104Fat digestion and absorption_Homo sapiens_hsa049750.32437755
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31320360
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.31181677
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31155725
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30648848
109HTLV-I infection_Homo sapiens_hsa051660.30062065
110Asthma_Homo sapiens_hsa053100.29287804
111Fructose and mannose metabolism_Homo sapiens_hsa000510.28957266
112Phototransduction_Homo sapiens_hsa047440.28903037
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28282439
114Retinol metabolism_Homo sapiens_hsa008300.28233871
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27659334
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26758145
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25931529
118beta-Alanine metabolism_Homo sapiens_hsa004100.25911314
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24368601
120Alcoholism_Homo sapiens_hsa050340.24283747
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23761157
122Wnt signaling pathway_Homo sapiens_hsa043100.23336211
123Peroxisome_Homo sapiens_hsa041460.22827333
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22394110
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21311141
126Linoleic acid metabolism_Homo sapiens_hsa005910.20914300
127Chemical carcinogenesis_Homo sapiens_hsa052040.20006829
128Other glycan degradation_Homo sapiens_hsa005110.19378758
129Carbon metabolism_Homo sapiens_hsa012000.19287888
130Influenza A_Homo sapiens_hsa051640.18975909
131Apoptosis_Homo sapiens_hsa042100.18529564
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17502985
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13513355
134Alzheimers disease_Homo sapiens_hsa050100.13304970
135Phenylalanine metabolism_Homo sapiens_hsa003600.11243946
136Sphingolipid metabolism_Homo sapiens_hsa006000.09627193
137Hepatitis B_Homo sapiens_hsa051610.09447533
138Small cell lung cancer_Homo sapiens_hsa052220.06974070

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