GEMIN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)4.99847242
2DNA strand elongation involved in DNA replication (GO:0006271)4.97179714
3DNA replication initiation (GO:0006270)4.90565542
4DNA unwinding involved in DNA replication (GO:0006268)4.76559902
5DNA strand elongation (GO:0022616)4.72873158
6IMP biosynthetic process (GO:0006188)4.67915356
7maturation of SSU-rRNA (GO:0030490)4.62659470
8purine nucleobase biosynthetic process (GO:0009113)4.53465871
9telomere maintenance via semi-conservative replication (GO:0032201)4.45388403
10spliceosomal tri-snRNP complex assembly (GO:0000244)4.42075486
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.28045581
12DNA replication checkpoint (GO:0000076)4.26178598
13DNA replication-dependent nucleosome assembly (GO:0006335)4.24174658
14DNA replication-dependent nucleosome organization (GO:0034723)4.24174658
15nuclear pore organization (GO:0006999)4.23598198
16formation of translation preinitiation complex (GO:0001731)4.22829554
17regulation of translational fidelity (GO:0006450)4.21960643
18ribosomal small subunit assembly (GO:0000028)4.21405633
19IMP metabolic process (GO:0046040)4.16434079
20mitotic metaphase plate congression (GO:0007080)4.01604154
21mitotic sister chromatid cohesion (GO:0007064)4.01577811
22folic acid-containing compound biosynthetic process (GO:0009396)4.00655225
23nuclear pore complex assembly (GO:0051292)3.99586103
24ribosome biogenesis (GO:0042254)3.99418912
25protein localization to kinetochore (GO:0034501)3.98634566
26mitotic nuclear envelope disassembly (GO:0007077)3.90941472
27telomere maintenance via recombination (GO:0000722)3.90138666
28ribosomal large subunit biogenesis (GO:0042273)3.85413150
29ribosome assembly (GO:0042255)3.85044355
30ribonucleoprotein complex biogenesis (GO:0022613)3.83914059
31DNA deamination (GO:0045006)3.73704447
32telomere maintenance via telomere lengthening (GO:0010833)3.69776681
33negative regulation of mRNA processing (GO:0050686)3.68389904
34viral transcription (GO:0019083)3.66924129
35chromatin remodeling at centromere (GO:0031055)3.66242822
36mitotic recombination (GO:0006312)3.66199810
37translational termination (GO:0006415)3.61701533
38rRNA transcription (GO:0009303)3.60795591
39CENP-A containing nucleosome assembly (GO:0034080)3.59878056
40membrane disassembly (GO:0030397)3.59528248
41nuclear envelope disassembly (GO:0051081)3.59528248
42ribosomal small subunit biogenesis (GO:0042274)3.57721908
43* spliceosomal snRNP assembly (GO:0000387)3.57060879
44metaphase plate congression (GO:0051310)3.52501219
45heterochromatin organization (GO:0070828)3.51311025
46regulation of mammary gland epithelial cell proliferation (GO:0033599)3.51087650
47protein localization to chromosome, centromeric region (GO:0071459)3.49179690
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.48426685
49* rRNA processing (GO:0006364)3.48151193
50translational elongation (GO:0006414)3.45216885
51chromosome condensation (GO:0030261)3.44303267
52translational initiation (GO:0006413)3.41740746
53pseudouridine synthesis (GO:0001522)3.41555530
54* rRNA metabolic process (GO:0016072)3.37951297
55regulation of posttranscriptional gene silencing (GO:0060147)3.36326672
56regulation of gene silencing by miRNA (GO:0060964)3.36326672
57regulation of gene silencing by RNA (GO:0060966)3.36326672
58negative regulation of RNA splicing (GO:0033119)3.35988154
59viral mRNA export from host cell nucleus (GO:0046784)3.35971671
60negative regulation of mRNA metabolic process (GO:1903312)3.34684037
61DNA duplex unwinding (GO:0032508)3.32111882
62regulation of translational termination (GO:0006449)3.31910874
63DNA geometric change (GO:0032392)3.31315672
64regulation of histone H3-K9 methylation (GO:0051570)3.30753599
65nuclear envelope organization (GO:0006998)3.30307403
66DNA replication-independent nucleosome organization (GO:0034724)3.28326979
67DNA replication-independent nucleosome assembly (GO:0006336)3.28326979
68proline biosynthetic process (GO:0006561)3.26188993
69establishment of integrated proviral latency (GO:0075713)3.26179241
70mitotic sister chromatid segregation (GO:0000070)3.25089358
71somatic hypermutation of immunoglobulin genes (GO:0016446)3.24984320
72somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24984320
73histone exchange (GO:0043486)3.23413474
74peptidyl-arginine methylation (GO:0018216)3.23304665
75peptidyl-arginine N-methylation (GO:0035246)3.23304665
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22312413
77DNA topological change (GO:0006265)3.22158169
78establishment of chromosome localization (GO:0051303)3.19230232
79cellular protein complex localization (GO:0034629)3.17720652
80nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17597257
81establishment of viral latency (GO:0019043)3.16291381
82DNA packaging (GO:0006323)3.12110118
83folic acid metabolic process (GO:0046655)3.11889235
84rRNA modification (GO:0000154)3.10905000
85peptidyl-arginine omega-N-methylation (GO:0035247)3.09264860
86transcription-coupled nucleotide-excision repair (GO:0006283)3.08927427
87kinetochore organization (GO:0051383)3.07336356
88pore complex assembly (GO:0046931)3.04822065
89DNA synthesis involved in DNA repair (GO:0000731)3.01620989
90negative regulation of chromosome segregation (GO:0051985)3.00230614
91chromatin assembly (GO:0031497)2.99717936
92histone arginine methylation (GO:0034969)2.99514950
93regulation of mitochondrial translation (GO:0070129)2.98447987
94regulation of helicase activity (GO:0051095)2.97957900
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96839845
96negative regulation of sister chromatid segregation (GO:0033046)2.96839845
97negative regulation of mitotic sister chromatid separation (GO:2000816)2.96839845
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96839845
99mitotic nuclear envelope reassembly (GO:0007084)2.95875461
100nuclear envelope reassembly (GO:0031468)2.95875461
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93627767
102tRNA methylation (GO:0030488)2.93035873
103nucleobase-containing small molecule interconversion (GO:0015949)2.92637172
104mitotic chromosome condensation (GO:0007076)2.92587997
105protein complex localization (GO:0031503)2.92363720
106regulation of chromosome segregation (GO:0051983)2.92098284
107regulation of spindle organization (GO:0090224)2.91769175
108cellular protein complex disassembly (GO:0043624)2.91216557
109mismatch repair (GO:0006298)2.91009695
110DNA conformation change (GO:0071103)2.90611352
111nucleosome disassembly (GO:0006337)2.89880224
112protein-DNA complex disassembly (GO:0032986)2.89880224
113cellular component biogenesis (GO:0044085)2.89866625
114positive regulation of chromosome segregation (GO:0051984)2.89195414
115spliceosomal complex assembly (GO:0000245)2.88522167
116regulation of centrosome cycle (GO:0046605)2.88343706
117mitotic spindle assembly checkpoint (GO:0007094)2.87937341
118spindle assembly checkpoint (GO:0071173)2.87609247
119L-serine metabolic process (GO:0006563)2.87068463
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86719834
121regulation of RNA export from nucleus (GO:0046831)2.86385319
122sister chromatid segregation (GO:0000819)2.86209126
123base-excision repair (GO:0006284)2.85110963
124regulation of double-strand break repair via homologous recombination (GO:0010569)2.84906496
125cotranslational protein targeting to membrane (GO:0006613)2.84641387
126G1/S transition of mitotic cell cycle (GO:0000082)2.84432445
127cell cycle G1/S phase transition (GO:0044843)2.84432445
128spindle checkpoint (GO:0031577)2.84075365
129protein targeting to ER (GO:0045047)2.84052693
130chromatin assembly or disassembly (GO:0006333)2.83495124
131viral life cycle (GO:0019058)2.82639184
132regulation of sister chromatid cohesion (GO:0007063)2.82241297
133transcription from mitochondrial promoter (GO:0006390)2.81949522
134mitotic spindle checkpoint (GO:0071174)2.81133731
135kinetochore assembly (GO:0051382)2.80955890
136anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80659053
137tRNA aminoacylation for protein translation (GO:0006418)2.79685470
138termination of RNA polymerase II transcription (GO:0006369)2.77996026
139mitochondrial RNA metabolic process (GO:0000959)2.75914320
140amino acid activation (GO:0043038)2.74827820
141tRNA aminoacylation (GO:0043039)2.74827820
142mRNA splicing, via spliceosome (GO:0000398)2.73995490
143RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.73995490
144regulation of chromatin binding (GO:0035561)2.73979344
145double-strand break repair via nonhomologous end joining (GO:0006303)2.72158545
146non-recombinational repair (GO:0000726)2.72158545
147mitochondrial fusion (GO:0008053)2.70475157
148DNA ligation (GO:0006266)2.69857467
149chromosome segregation (GO:0007059)2.67462837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.77513341
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.55892880
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69051611
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.63807426
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62708140
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.26175646
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04678971
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01131025
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97297298
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.96234300
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91110796
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71493492
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69435231
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.66737096
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.59159973
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48570410
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47250965
18XRN2_22483619_ChIP-Seq_HELA_Human2.41329162
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40374932
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36949531
21AR_21909140_ChIP-Seq_LNCAP_Human2.17872913
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07990640
23* VDR_23849224_ChIP-Seq_CD4+_Human2.05569543
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05292386
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.00179290
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99944893
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90616053
28* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89154966
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.85866058
30FOXP3_21729870_ChIP-Seq_TREG_Human1.85378412
31DCP1A_22483619_ChIP-Seq_HELA_Human1.82808750
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82128604
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.81010611
34TTF2_22483619_ChIP-Seq_HELA_Human1.79348881
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78932732
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75234308
37* GABP_19822575_ChIP-Seq_HepG2_Human1.74556205
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72254781
39ZNF263_19887448_ChIP-Seq_K562_Human1.66461097
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66436220
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65016446
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63461343
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.60004446
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58604810
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56020469
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53759671
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52943954
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49827169
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49823021
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49208227
51CIITA_25753668_ChIP-Seq_RAJI_Human1.48676480
52MYC_22102868_ChIP-Seq_BL_Human1.48130990
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45670917
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45328345
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.43826236
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43759351
57ELK1_19687146_ChIP-ChIP_HELA_Human1.43314679
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40785874
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40437125
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.39367220
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37314574
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32200388
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.30278691
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30103521
65KDM5A_27292631_Chip-Seq_BREAST_Human1.28836823
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28422894
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.26349521
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25796288
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23799379
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23773325
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.22989176
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20031724
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19976641
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18997994
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15383326
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14352599
77LXR_22292898_ChIP-Seq_THP-1_Human1.13981314
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12357706
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.11568032
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.09173512
81* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09166009
82* RACK7_27058665_Chip-Seq_MCF-7_Human1.09114039
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06843267
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06843267
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06843267
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06275373
87CHD1_26751641_Chip-Seq_LNCaP_Human1.05786871
88* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05457713
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05006212
90* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03138843
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02972198
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01823061
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01676448
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00968950
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00008769
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99312450
97ATF3_27146783_Chip-Seq_COLON_Human0.98994741
98TFEB_21752829_ChIP-Seq_HELA_Human0.97417825
99MYC_18940864_ChIP-ChIP_HL60_Human0.96665251
100TCF7_22412390_ChIP-Seq_EML_Mouse0.96116490
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95611618
102* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95190386
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94379117
104P68_20966046_ChIP-Seq_HELA_Human0.93727859
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93481289
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93208195
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93205169
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92937701
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.92225033
110MAF_26560356_Chip-Seq_TH1_Human0.92100300
111MAF_26560356_Chip-Seq_TH2_Human0.91866478
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91865205
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91845722
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91591854
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90700690
116* FOXP1_21924763_ChIP-Seq_HESCs_Human0.90316521
117* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90227064
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89721748
119* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89519740
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89353151
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87611716
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87090196
123VDR_21846776_ChIP-Seq_THP-1_Human0.84483362
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84210011
125* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83907993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.96155828
2MP0010094_abnormal_chromosome_stability4.81096288
3MP0003111_abnormal_nucleus_morphology4.49967073
4MP0004957_abnormal_blastocyst_morpholog4.37377141
5MP0008057_abnormal_DNA_replication4.26611535
6MP0003077_abnormal_cell_cycle3.95336920
7MP0008058_abnormal_DNA_repair3.41999799
8MP0008932_abnormal_embryonic_tissue2.90218266
9MP0008007_abnormal_cellular_replicative2.72254830
10MP0003123_paternal_imprinting2.67877191
11MP0001730_embryonic_growth_arrest2.61211746
12MP0003806_abnormal_nucleotide_metabolis2.43175663
13MP0000350_abnormal_cell_proliferation2.41462644
14MP0010030_abnormal_orbit_morphology2.34300271
15MP0008877_abnormal_DNA_methylation2.33958189
16MP0003705_abnormal_hypodermis_morpholog2.24476709
17MP0010352_gastrointestinal_tract_polyps2.19759921
18MP0002396_abnormal_hematopoietic_system2.15181091
19MP0005623_abnormal_meninges_morphology2.06320303
20MP0002877_abnormal_melanocyte_morpholog2.00504237
21MP0001672_abnormal_embryogenesis/_devel1.99515364
22MP0005380_embryogenesis_phenotype1.99515364
23MP0003786_premature_aging1.93148620
24MP0001697_abnormal_embryo_size1.92834707
25MP0000566_synostosis1.92482473
26MP0004185_abnormal_adipocyte_glucose1.89211544
27MP0001346_abnormal_lacrimal_gland1.84305276
28MP0003984_embryonic_growth_retardation1.81521714
29MP0002088_abnormal_embryonic_growth/wei1.77399266
30MP0005451_abnormal_body_composition1.76251830
31MP0002085_abnormal_embryonic_tissue1.72344701
32MP0002084_abnormal_developmental_patter1.71808041
33MP0002080_prenatal_lethality1.68896166
34MP0000490_abnormal_crypts_of1.64166318
35MP0003890_abnormal_embryonic-extraembry1.60596606
36MP0010307_abnormal_tumor_latency1.58792255
37MP0001293_anophthalmia1.57363144
38MP0004133_heterotaxia1.57116949
39MP0002086_abnormal_extraembryonic_tissu1.56343428
40MP0004197_abnormal_fetal_growth/weight/1.54196634
41MP0005501_abnormal_skin_physiology1.49497951
42MP0005410_abnormal_fertilization1.46601225
43MP0003718_maternal_effect1.45459866
44MP0000313_abnormal_cell_death1.45200384
45MP0002796_impaired_skin_barrier1.43916087
46MP0002210_abnormal_sex_determination1.42596453
47MP0003119_abnormal_digestive_system1.36834542
48MP0001929_abnormal_gametogenesis1.36750999
49MP0002009_preneoplasia1.36585383
50MP0004808_abnormal_hematopoietic_stem1.34568489
51MP0008260_abnormal_autophagy1.34534671
52MP0002019_abnormal_tumor_incidence1.32800736
53MP0003567_abnormal_fetal_cardiomyocyte1.32410995
54MP0001145_abnormal_male_reproductive1.29798919
55MP0010234_abnormal_vibrissa_follicle1.29175046
56MP0003121_genomic_imprinting1.26475483
57MP0009278_abnormal_bone_marrow1.26346246
58MP0000678_abnormal_parathyroid_gland1.18923704
59MP0000537_abnormal_urethra_morphology1.18376726
60MP0002160_abnormal_reproductive_system1.13241353
61MP0005397_hematopoietic_system_phenotyp1.12582106
62MP0001545_abnormal_hematopoietic_system1.12582106
63MP0003315_abnormal_perineum_morphology1.12537783
64MP0001661_extended_life_span1.12108031
65MP0003941_abnormal_skin_development1.10179116
66MP0000653_abnormal_sex_gland1.05062586
67MP0006292_abnormal_olfactory_placode1.03391656
68MP0000003_abnormal_adipose_tissue1.01076781
69MP0002653_abnormal_ependyma_morphology1.00538258
70MP0003698_abnormal_male_reproductive0.99158286
71MP0000579_abnormal_nail_morphology0.96551644
72MP0009333_abnormal_splenocyte_physiolog0.96134234
73MP0003453_abnormal_keratinocyte_physiol0.95349126
74MP0002111_abnormal_tail_morphology0.94519935
75MP0000703_abnormal_thymus_morphology0.94117701
76MP0002697_abnormal_eye_size0.92992261
77MP0001348_abnormal_lacrimal_gland0.92502452
78MP0009053_abnormal_anal_canal0.90492409
79MP0003186_abnormal_redox_activity0.88295897
80MP0002060_abnormal_skin_morphology0.88286483
81MP0000358_abnormal_cell_content/0.87355731
82MP0003937_abnormal_limbs/digits/tail_de0.87261359
83MP0002102_abnormal_ear_morphology0.86222479
84MP0009672_abnormal_birth_weight0.84947954
85MP0000049_abnormal_middle_ear0.82004273
86MP0001216_abnormal_epidermal_layer0.81684216
87MP0002722_abnormal_immune_system0.81171834
88MP0003943_abnormal_hepatobiliary_system0.79538299
89MP0003566_abnormal_cell_adhesion0.78951321
90MP0000733_abnormal_muscle_development0.78671821
91MP0005266_abnormal_metabolism0.78191662
92MP0009697_abnormal_copulation0.77302679
93MP0005023_abnormal_wound_healing0.75920948
94MP0005075_abnormal_melanosome_morpholog0.75587020
95MP0005666_abnormal_adipose_tissue0.75361947
96MP0002398_abnormal_bone_marrow0.75074999
97MP0000467_abnormal_esophagus_morphology0.74619784
98MP0002092_abnormal_eye_morphology0.74365736
99MP0002132_abnormal_respiratory_system0.73817013
100MP0000689_abnormal_spleen_morphology0.73661329
101MP0005384_cellular_phenotype0.72593935
102MP0002161_abnormal_fertility/fecundity0.72206961
103MP0002006_tumorigenesis0.71080800
104MP0003763_abnormal_thymus_physiology0.70856237
105MP0009931_abnormal_skin_appearance0.70642784
106MP0001119_abnormal_female_reproductive0.69694818
107MP0000428_abnormal_craniofacial_morphol0.69680582
108MP0002098_abnormal_vibrissa_morphology0.69438694
109MP0005375_adipose_tissue_phenotype0.69267443
110MP0002089_abnormal_postnatal_growth/wei0.69253447
111MP0001849_ear_inflammation0.68869922
112MP0002166_altered_tumor_susceptibility0.68114906
113MP0000762_abnormal_tongue_morphology0.67700964
114MP0003221_abnormal_cardiomyocyte_apopto0.67643630
115MP0002970_abnormal_white_adipose0.66886541
116MP0001286_abnormal_eye_development0.66649390
117MP0004264_abnormal_extraembryonic_tissu0.66473743
118MP0003385_abnormal_body_wall0.66219022
119MP0006036_abnormal_mitochondrial_physio0.66183955
120MP0004233_abnormal_muscle_weight0.65329564
121MP0000627_abnormal_mammary_gland0.65281580
122MP0003115_abnormal_respiratory_system0.64739075
123MP0005389_reproductive_system_phenotype0.64606310
124MP0004858_abnormal_nervous_system0.64113296
125MP0002751_abnormal_autonomic_nervous0.64007523
126MP0005220_abnormal_exocrine_pancreas0.63694922
127MP0002249_abnormal_larynx_morphology0.63674063
128MP0003942_abnormal_urinary_system0.63625784
129MP0000477_abnormal_intestine_morphology0.62009057
130MP0006035_abnormal_mitochondrial_morpho0.61874531
131MP0005621_abnormal_cell_physiology0.61652888
132MP0005076_abnormal_cell_differentiation0.60049522
133MP0002429_abnormal_blood_cell0.59987054
134MP0000858_altered_metastatic_potential0.59866979
135MP0001915_intracranial_hemorrhage0.58258205
136MP0009379_abnormal_foot_pigmentation0.58252777
137MP0009703_decreased_birth_body0.57876027
138MP0008770_decreased_survivor_rate0.56841968
139MP0003861_abnormal_nervous_system0.54740157
140MP0002269_muscular_atrophy0.54450957

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.92104745
2Reticulocytopenia (HP:0001896)4.44617724
3Microvesicular hepatic steatosis (HP:0001414)4.13257432
4Abnormality of cells of the erythroid lineage (HP:0012130)3.72795204
5Breast hypoplasia (HP:0003187)3.71174642
6Chromsome breakage (HP:0040012)3.67969945
7Selective tooth agenesis (HP:0001592)3.63092541
8Ependymoma (HP:0002888)3.57788674
9Absent radius (HP:0003974)3.53057645
10Oral leukoplakia (HP:0002745)3.48223996
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46953256
12Abnormal number of erythroid precursors (HP:0012131)3.44681151
13Abnormality of the anterior horn cell (HP:0006802)3.42231430
14Degeneration of anterior horn cells (HP:0002398)3.42231430
15Aplasia involving forearm bones (HP:0009822)3.34520102
16Absent forearm bone (HP:0003953)3.34520102
17Colon cancer (HP:0003003)3.33056054
18Medulloblastoma (HP:0002885)3.24335332
19Ragged-red muscle fibers (HP:0003200)3.22717979
20Absent thumb (HP:0009777)3.20197118
21Aplastic anemia (HP:0001915)3.17002075
22Septate vagina (HP:0001153)3.04920555
23Hyperacusis (HP:0010780)3.03596473
24Cerebral hypomyelination (HP:0006808)3.03004761
25Abnormality of the preputium (HP:0100587)2.98679694
26Supernumerary spleens (HP:0009799)2.95618620
27Squamous cell carcinoma (HP:0002860)2.92867075
28Patellar aplasia (HP:0006443)2.91318750
29Carpal bone hypoplasia (HP:0001498)2.89121747
30Rough bone trabeculation (HP:0100670)2.89041089
31Meckel diverticulum (HP:0002245)2.88861342
32Agnosia (HP:0010524)2.86879771
33Impulsivity (HP:0100710)2.86178792
34Abnormality of chromosome stability (HP:0003220)2.84893018
35Progressive external ophthalmoplegia (HP:0000590)2.81980733
36Abnormality of the ileum (HP:0001549)2.81564108
37Aplasia/Hypoplasia of the patella (HP:0006498)2.79499827
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.76144222
39Abnormality of the distal phalanges of the toes (HP:0010182)2.63057783
40Macrocytic anemia (HP:0001972)2.62223159
41Duplicated collecting system (HP:0000081)2.61994846
42Broad distal phalanx of finger (HP:0009836)2.59569445
43Poikiloderma (HP:0001029)2.51764973
4411 pairs of ribs (HP:0000878)2.51663653
45Rhabdomyosarcoma (HP:0002859)2.51435919
46Abnormality of the labia minora (HP:0012880)2.50600647
47Myelodysplasia (HP:0002863)2.47825172
48Horseshoe kidney (HP:0000085)2.46106752
49Sparse lateral eyebrow (HP:0005338)2.45833038
50Trismus (HP:0000211)2.43768057
51Ectopic kidney (HP:0000086)2.43477977
52Long palpebral fissure (HP:0000637)2.42922221
53Testicular atrophy (HP:0000029)2.42170998
54Pallor (HP:0000980)2.41508332
55Premature graying of hair (HP:0002216)2.39171463
56Abnormality of pyrimidine metabolism (HP:0004353)2.38322429
57Hypoplasia of the radius (HP:0002984)2.38065367
58Triphalangeal thumb (HP:0001199)2.37579670
59High anterior hairline (HP:0009890)2.37115905
60Abnormal number of incisors (HP:0011064)2.35499120
61Small intestinal stenosis (HP:0012848)2.35396598
62Duodenal stenosis (HP:0100867)2.35396598
63Aplasia/hypoplasia of the humerus (HP:0006507)2.33293611
64Abnormality of the phalanges of the hallux (HP:0010057)2.33146523
65Asplenia (HP:0001746)2.33009583
66Abnormality of the columella (HP:0009929)2.31754967
67Ulnar bowing (HP:0003031)2.30674176
68Duplication of thumb phalanx (HP:0009942)2.29620452
69Bone marrow hypocellularity (HP:0005528)2.29586464
70Neoplasm of the pancreas (HP:0002894)2.28780709
71Sloping forehead (HP:0000340)2.28524405
72Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.27538284
73Atresia of the external auditory canal (HP:0000413)2.24221241
74Microretrognathia (HP:0000308)2.21833416
75Proximal placement of thumb (HP:0009623)2.19550208
76Deviation of the thumb (HP:0009603)2.16687560
77Tracheoesophageal fistula (HP:0002575)2.16626913
78Abnormality of the umbilical cord (HP:0010881)2.16116082
79Aplasia/Hypoplasia of the spleen (HP:0010451)2.13624017
80Basal cell carcinoma (HP:0002671)2.12465931
81Increased nuchal translucency (HP:0010880)2.11999872
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11701097
83Missing ribs (HP:0000921)2.11639709
84Abnormality of the renal collecting system (HP:0004742)2.11541456
85Abnormality of the duodenum (HP:0002246)2.11526451
86Abnormality of the astrocytes (HP:0100707)2.10664168
87Astrocytoma (HP:0009592)2.10664168
88Preauricular skin tag (HP:0000384)2.09649262
89Abnormality of the distal phalanx of the thumb (HP:0009617)2.07107769
90Partial duplication of thumb phalanx (HP:0009944)2.06369237
91Premature ovarian failure (HP:0008209)2.05335331
92Abnormal trabecular bone morphology (HP:0100671)2.04925138
93Cellular immunodeficiency (HP:0005374)2.04839813
94Abnormal umbilical cord blood vessels (HP:0011403)2.04576959
95Single umbilical artery (HP:0001195)2.04576959
96Abnormality of the fetal cardiovascular system (HP:0010948)2.04576959
97Atrophy/Degeneration involving motor neurons (HP:0007373)2.04246529
98Abnormal lung lobation (HP:0002101)2.03949658
99Short humerus (HP:0005792)2.03550947
100Progressive muscle weakness (HP:0003323)2.03216385
101Abdominal situs inversus (HP:0003363)2.03132732
102Abnormality of abdominal situs (HP:0011620)2.03132732
103Insomnia (HP:0100785)2.00212901
104Multiple enchondromatosis (HP:0005701)1.99466778
105Facial cleft (HP:0002006)1.98923272
106Abnormality of the fingertips (HP:0001211)1.98882682
107Glioma (HP:0009733)1.98753338
108Pancytopenia (HP:0001876)1.97923553
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97863591
110Urethral obstruction (HP:0000796)1.96885453
111Rectovaginal fistula (HP:0000143)1.96502379
112Rectal fistula (HP:0100590)1.96502379
113Lip pit (HP:0100267)1.96381741
114Stenosis of the external auditory canal (HP:0000402)1.95991390
115Glossoptosis (HP:0000162)1.93008434
116Ureteral duplication (HP:0000073)1.92800750
117Amaurosis fugax (HP:0100576)1.92350318
118Short thumb (HP:0009778)1.92305532
119Partial duplication of the phalanx of hand (HP:0009999)1.91055605
120Abnormality of the salivary glands (HP:0010286)1.90911331
121Hypergonadotropic hypogonadism (HP:0000815)1.89546215
122Long eyelashes (HP:0000527)1.89078615
123Neoplasm of striated muscle (HP:0009728)1.87966788
124Achilles tendon contracture (HP:0001771)1.87918580
125Abnormality of glycolysis (HP:0004366)1.83411907
126Abnormality of the carotid arteries (HP:0005344)1.82849586
127Prominent nose (HP:0000448)1.82780989
128Esophageal atresia (HP:0002032)1.80810523
129Cleft eyelid (HP:0000625)1.80400786
130Progressive hearing impairment (HP:0001730)1.80389736
131Skin tags (HP:0010609)1.80155868
132Neoplasm of the oral cavity (HP:0100649)1.78751513
133Tongue fasciculations (HP:0001308)1.77824646
134Abnormality of the calcaneus (HP:0008364)1.77074741
135Secondary amenorrhea (HP:0000869)1.77013009
136Facial hemangioma (HP:0000329)1.76706276
137Abnormality of reticulocytes (HP:0004312)1.76656187
138Entropion (HP:0000621)1.76149764
139Choanal atresia (HP:0000453)1.74936308
140Broad face (HP:0000283)1.72877646
141Self-mutilation (HP:0000742)1.68133100
142Overriding aorta (HP:0002623)1.63620406
143Abnormality of cochlea (HP:0000375)1.63139855
144Trigonocephaly (HP:0000243)1.61933888
145Abnormality of DNA repair (HP:0003254)1.59967534
146Nephroblastoma (Wilms tumor) (HP:0002667)1.59780062
147Overlapping toe (HP:0001845)1.59779371
148Coarctation of aorta (HP:0001680)1.59601296
149Spastic diplegia (HP:0001264)1.58431959
150Dysmetric saccades (HP:0000641)1.58214800
151Abnormalities of placenta or umbilical cord (HP:0001194)1.56970243
152Premature skin wrinkling (HP:0100678)1.56919687
153Intestinal fistula (HP:0100819)1.55981675
154Deep philtrum (HP:0002002)1.55255345
155Neonatal hypoglycemia (HP:0001998)1.54196657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.53530145
2SMG14.50611510
3WEE14.49161041
4CDC74.27097501
5EIF2AK13.28209377
6VRK22.89533578
7TSSK62.74534056
8NEK22.48961192
9ICK2.48061813
10TRIB32.47934799
11TTK2.41292784
12TLK12.21235986
13SRPK12.20184351
14NEK12.10792367
15PLK12.07797394
16IRAK31.94798129
17CDK71.90976026
18DYRK31.88697898
19PASK1.83489017
20BRSK21.83207928
21RPS6KB21.82982536
22ATR1.80750204
23MKNK11.79422689
24EIF2AK31.78036384
25CDK121.73443631
26PLK41.71879243
27VRK11.71163748
28NME21.70525823
29PRPF4B1.64820175
30STK161.64276358
31TESK21.63434932
32TAF11.61591544
33AURKB1.61263631
34ACVR1B1.58014995
35SCYL21.51051061
36PLK31.48786618
37CHEK21.42337814
38EPHA21.40607663
39TESK11.40028848
40EEF2K1.34731588
41AURKA1.34324318
42MST1R1.33704629
43CDK41.33611445
44CHEK11.31655387
45STK101.31390691
46MAP3K81.31341323
47PAK41.26740377
48ZAK1.20406337
49STK41.14137585
50PDK41.10219223
51PDK31.10219223
52TAOK21.04619826
53BRSK11.04592983
54MKNK21.04164903
55CDK81.04030876
56RPS6KA41.03574486
57BCKDK1.02451320
58TGFBR11.00963222
59CAMK1D0.99289811
60ARAF0.97563966
61ATM0.90965016
62CDK20.90341895
63MAP3K100.84171743
64SIK10.84136304
65MAPK110.82262442
66ALK0.81299133
67CSNK2A20.81225640
68CDK90.81031263
69PAK10.77213087
70CCNB10.76117557
71PIM10.75928938
72MAP3K110.74635143
73RAF10.74378647
74CAMK1G0.70731598
75MELK0.70406310
76AKT30.69990940
77TTN0.68245107
78CSNK2A10.67800188
79PDK20.66847278
80EIF2AK20.64596822
81ERN10.63641102
82PNCK0.63328112
83CDK10.62933301
84BRD40.62104954
85FLT30.61271606
86FGFR10.60258433
87PBK0.59921638
88CLK10.59454251
89LRRK20.59380299
90MAP2K30.59200760
91LATS20.57094553
92PKN20.52632557
93STK30.50090108
94MTOR0.49662870
95AKT20.49030018
96PIM20.48419463
97KDR0.47984067
98DAPK10.47523118
99BRAF0.46587860
100RPS6KA50.43976346
101MAPKAPK30.41999107
102RPS6KA10.41478420
103STK38L0.41208451
104MAP3K90.40071245
105MAP4K10.39925090
106RPS6KL10.39358751
107RPS6KC10.39358751
108MET0.39301700
109CSNK1E0.39049695
110CDK60.39048022
111PRKDC0.37877484
112PAK20.37128772
113PRKCI0.33476039
114GRK60.32995778
115YES10.32350983
116IRAK20.31709823
117FGFR40.31376341
118BTK0.30172017
119BMX0.27639502
120MST40.26827934
121CSNK1D0.25563393
122LIMK10.25247409
123RPS6KB10.24885328
124NME10.24773563
125ILK0.22815574
126MAPK140.19651141
127CDK190.18065453
128DYRK20.17958430

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.03961777
2Mismatch repair_Homo sapiens_hsa034304.44211134
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.95296027
4Ribosome_Homo sapiens_hsa030103.49197267
5RNA polymerase_Homo sapiens_hsa030203.37580154
6Spliceosome_Homo sapiens_hsa030403.31631451
7* RNA transport_Homo sapiens_hsa030133.19346986
8Base excision repair_Homo sapiens_hsa034103.11019363
9Homologous recombination_Homo sapiens_hsa034403.05710807
10One carbon pool by folate_Homo sapiens_hsa006702.95854900
11Proteasome_Homo sapiens_hsa030502.93093516
12Nucleotide excision repair_Homo sapiens_hsa034202.76227729
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.73640759
14Pyrimidine metabolism_Homo sapiens_hsa002402.58078454
15Cell cycle_Homo sapiens_hsa041102.55493132
16Fanconi anemia pathway_Homo sapiens_hsa034602.23360871
17Non-homologous end-joining_Homo sapiens_hsa034502.00905034
18Basal transcription factors_Homo sapiens_hsa030221.92810992
19RNA degradation_Homo sapiens_hsa030181.90838470
20mRNA surveillance pathway_Homo sapiens_hsa030151.65648690
21Purine metabolism_Homo sapiens_hsa002301.43207548
22Systemic lupus erythematosus_Homo sapiens_hsa053221.40770235
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.40558806
24Biosynthesis of amino acids_Homo sapiens_hsa012301.35621612
25p53 signaling pathway_Homo sapiens_hsa041151.33545322
26Lysine degradation_Homo sapiens_hsa003101.23343932
27Chronic myeloid leukemia_Homo sapiens_hsa052201.18430321
28Selenocompound metabolism_Homo sapiens_hsa004501.18288940
29Epstein-Barr virus infection_Homo sapiens_hsa051691.07419728
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.03865200
31Pentose phosphate pathway_Homo sapiens_hsa000300.97800394
32Vitamin B6 metabolism_Homo sapiens_hsa007500.97093985
33Viral carcinogenesis_Homo sapiens_hsa052030.95282555
34Oocyte meiosis_Homo sapiens_hsa041140.91850246
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89043572
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87754260
37Drug metabolism - other enzymes_Homo sapiens_hsa009830.85468729
38Non-small cell lung cancer_Homo sapiens_hsa052230.84852120
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82976628
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81311116
41Antigen processing and presentation_Homo sapiens_hsa046120.80628456
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80423838
43Carbon metabolism_Homo sapiens_hsa012000.80330195
44Pancreatic cancer_Homo sapiens_hsa052120.77466706
45Folate biosynthesis_Homo sapiens_hsa007900.75071071
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74434766
47Huntingtons disease_Homo sapiens_hsa050160.72332530
48Basal cell carcinoma_Homo sapiens_hsa052170.71968725
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71774981
50Glutathione metabolism_Homo sapiens_hsa004800.71393785
51Herpes simplex infection_Homo sapiens_hsa051680.70904495
52HTLV-I infection_Homo sapiens_hsa051660.69812176
53Prostate cancer_Homo sapiens_hsa052150.68866297
54Thyroid cancer_Homo sapiens_hsa052160.64030578
55Fructose and mannose metabolism_Homo sapiens_hsa000510.62591772
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61373741
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60783968
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59621782
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59362318
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55469638
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51821998
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50671609
63Endometrial cancer_Homo sapiens_hsa052130.49816131
64MicroRNAs in cancer_Homo sapiens_hsa052060.49317219
65Hippo signaling pathway_Homo sapiens_hsa043900.49262019
66Fatty acid biosynthesis_Homo sapiens_hsa000610.48577437
67Alcoholism_Homo sapiens_hsa050340.46604410
68Parkinsons disease_Homo sapiens_hsa050120.46582583
69Sulfur relay system_Homo sapiens_hsa041220.45750232
70Notch signaling pathway_Homo sapiens_hsa043300.45548369
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45322007
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44781816
73Steroid biosynthesis_Homo sapiens_hsa001000.44089275
74Legionellosis_Homo sapiens_hsa051340.44063239
75Hedgehog signaling pathway_Homo sapiens_hsa043400.42868938
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42490245
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42475202
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.41529932
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36286884
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35499602
81mTOR signaling pathway_Homo sapiens_hsa041500.34747605
82Small cell lung cancer_Homo sapiens_hsa052220.33128599
83AMPK signaling pathway_Homo sapiens_hsa041520.33049470
84TGF-beta signaling pathway_Homo sapiens_hsa043500.32900734
85Fatty acid elongation_Homo sapiens_hsa000620.31673478
86Metabolic pathways_Homo sapiens_hsa011000.30902624
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30479435
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29416439
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29371658
90HIF-1 signaling pathway_Homo sapiens_hsa040660.29341672
91Insulin signaling pathway_Homo sapiens_hsa049100.29040989
92Bladder cancer_Homo sapiens_hsa052190.27469544
93Galactose metabolism_Homo sapiens_hsa000520.27341814
94Melanoma_Homo sapiens_hsa052180.27052337
95Pyruvate metabolism_Homo sapiens_hsa006200.26515541
96Glioma_Homo sapiens_hsa052140.25336517
97Proteoglycans in cancer_Homo sapiens_hsa052050.24599949
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24431144
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23179902
100N-Glycan biosynthesis_Homo sapiens_hsa005100.23048474
101Apoptosis_Homo sapiens_hsa042100.22711031
102Protein export_Homo sapiens_hsa030600.21582410
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21446220
104Primary immunodeficiency_Homo sapiens_hsa053400.21288443
105Oxidative phosphorylation_Homo sapiens_hsa001900.20337071
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18330883
107Pathways in cancer_Homo sapiens_hsa052000.16785445
108Colorectal cancer_Homo sapiens_hsa052100.16083489
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15335566
110Wnt signaling pathway_Homo sapiens_hsa043100.12871974
111Measles_Homo sapiens_hsa051620.12026846
112Adherens junction_Homo sapiens_hsa045200.11273498
113Tight junction_Homo sapiens_hsa045300.10861351
114Shigellosis_Homo sapiens_hsa051310.08163446
115Renin-angiotensin system_Homo sapiens_hsa046140.08110088
116Arginine and proline metabolism_Homo sapiens_hsa003300.07854544
117Hepatitis B_Homo sapiens_hsa051610.06454847
118Arachidonic acid metabolism_Homo sapiens_hsa005900.06141265
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.04477236
120Linoleic acid metabolism_Homo sapiens_hsa005910.02928668
121Viral myocarditis_Homo sapiens_hsa054160.01923984
122Acute myeloid leukemia_Homo sapiens_hsa052210.01451901

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