GEMIN7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear 'gems' (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.80823120
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.77664874
3DNA deamination (GO:0045006)5.72599863
4chaperone-mediated protein transport (GO:0072321)5.20403375
5ATP synthesis coupled proton transport (GO:0015986)5.03082990
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.03082990
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.99886012
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.49822635
9protein complex biogenesis (GO:0070271)4.43768031
10viral transcription (GO:0019083)4.38893577
11mitochondrial respiratory chain complex assembly (GO:0033108)4.37442275
12maturation of SSU-rRNA (GO:0030490)4.32778853
13respiratory electron transport chain (GO:0022904)4.28850560
14translational termination (GO:0006415)4.27386652
15maturation of 5.8S rRNA (GO:0000460)4.24055106
16respiratory chain complex IV assembly (GO:0008535)4.23378742
17electron transport chain (GO:0022900)4.20924482
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.16234788
19NADH dehydrogenase complex assembly (GO:0010257)4.16234788
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.16234788
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.15810966
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.04228210
23cotranslational protein targeting to membrane (GO:0006613)4.03643019
24proteasome assembly (GO:0043248)4.02105943
25protein targeting to ER (GO:0045047)4.01633087
26ribosomal small subunit biogenesis (GO:0042274)4.00841049
27translational elongation (GO:0006414)4.00195644
28cytochrome complex assembly (GO:0017004)3.99785253
29formation of translation preinitiation complex (GO:0001731)3.92242108
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.89511178
31protein targeting to mitochondrion (GO:0006626)3.85363565
32telomere maintenance via semi-conservative replication (GO:0032201)3.83816051
33protein localization to endoplasmic reticulum (GO:0070972)3.82644623
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.76573047
35DNA strand elongation involved in DNA replication (GO:0006271)3.73693451
36establishment of integrated proviral latency (GO:0075713)3.71622579
37GTP biosynthetic process (GO:0006183)3.69865350
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.65860176
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.64590701
40establishment of protein localization to mitochondrion (GO:0072655)3.60472201
41translational initiation (GO:0006413)3.60246330
42DNA strand elongation (GO:0022616)3.60123233
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.59219272
44protein localization to mitochondrion (GO:0070585)3.57052663
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.54557467
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.51567645
47negative regulation of ligase activity (GO:0051352)3.51567645
48viral life cycle (GO:0019058)3.47099230
49ribosomal large subunit biogenesis (GO:0042273)3.44866374
50translation (GO:0006412)3.42867320
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42235614
52telomere maintenance via recombination (GO:0000722)3.41035630
53inner mitochondrial membrane organization (GO:0007007)3.40983619
54protein deneddylation (GO:0000338)3.39228713
55antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.39166121
56peptidyl-histidine modification (GO:0018202)3.37696510
57UTP biosynthetic process (GO:0006228)3.35913770
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.35837499
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.35837499
60establishment of viral latency (GO:0019043)3.34871723
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33739890
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33739890
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33739890
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33395171
65protein neddylation (GO:0045116)3.32515157
66cellular protein complex disassembly (GO:0043624)3.32432251
67DNA catabolic process, exonucleolytic (GO:0000738)3.32136125
68ribonucleoprotein complex biogenesis (GO:0022613)3.27291808
69regulation of cellular amino acid metabolic process (GO:0006521)3.26071809
70guanosine-containing compound biosynthetic process (GO:1901070)3.23747528
71rRNA methylation (GO:0031167)3.21881000
72signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21531835
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.21531835
74DNA double-strand break processing (GO:0000729)3.20729447
75positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20676566
76pseudouridine synthesis (GO:0001522)3.18828911
77DNA replication initiation (GO:0006270)3.18566966
78purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17131069
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.16574127
80cullin deneddylation (GO:0010388)3.14261598
81DNA damage response, detection of DNA damage (GO:0042769)3.13518445
82rRNA modification (GO:0000154)3.13158504
83pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.12939923
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12173539
85positive regulation of ligase activity (GO:0051351)3.11162734
86purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10334504
87transcription elongation from RNA polymerase III promoter (GO:0006385)3.10247046
88termination of RNA polymerase III transcription (GO:0006386)3.10247046
89base-excision repair, AP site formation (GO:0006285)3.09087891
90viral mRNA export from host cell nucleus (GO:0046784)3.08778260
91CTP metabolic process (GO:0046036)3.08473698
92CTP biosynthetic process (GO:0006241)3.08473698
93protein-cofactor linkage (GO:0018065)3.08313608
94intracellular protein transmembrane import (GO:0044743)3.07466080
95mitotic metaphase plate congression (GO:0007080)3.07289567
96CENP-A containing nucleosome assembly (GO:0034080)3.01941098
97ribosome biogenesis (GO:0042254)2.98884938
98telomere maintenance via telomere lengthening (GO:0010833)2.98602423
99mitotic recombination (GO:0006312)2.96520399
100rRNA processing (GO:0006364)2.93073885
101nucleobase-containing small molecule interconversion (GO:0015949)2.92448580
102DNA replication checkpoint (GO:0000076)2.91939094
1037-methylguanosine mRNA capping (GO:0006370)2.90354517
104protein complex disassembly (GO:0043241)2.89860796
105nucleobase biosynthetic process (GO:0046112)2.88424441
106transcription-coupled nucleotide-excision repair (GO:0006283)2.88416067
107chromatin remodeling at centromere (GO:0031055)2.88283632
108purine nucleobase biosynthetic process (GO:0009113)2.86694131
109* spliceosomal snRNP assembly (GO:0000387)2.86346478
110RNA capping (GO:0036260)2.83572405
1117-methylguanosine RNA capping (GO:0009452)2.83572405
112regulation of ubiquitin-protein transferase activity (GO:0051438)2.80965791
113purine-containing compound salvage (GO:0043101)2.80864354
114rRNA metabolic process (GO:0016072)2.79988069
115antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.79841100
116cellular component biogenesis (GO:0044085)2.79822199
117oxidative phosphorylation (GO:0006119)2.79335474
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79110283
119G1/S transition of mitotic cell cycle (GO:0000082)2.78800536
120cell cycle G1/S phase transition (GO:0044843)2.78800536
121macromolecular complex disassembly (GO:0032984)2.78614412
122signal peptide processing (GO:0006465)2.77896149
123DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.76522157
124positive regulation of cell cycle arrest (GO:0071158)2.76389522
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75442896
126kinetochore assembly (GO:0051382)2.75236820
127regulation of ligase activity (GO:0051340)2.74761159
128metallo-sulfur cluster assembly (GO:0031163)2.74033395
129iron-sulfur cluster assembly (GO:0016226)2.74033395
130nucleotide-excision repair, DNA gap filling (GO:0006297)2.73890150
131nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69113193
132nuclear-transcribed mRNA catabolic process (GO:0000956)2.68369213
133pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.65926413
134ribosome assembly (GO:0042255)2.65544011
135tRNA methylation (GO:0030488)2.65528773
136protein targeting to membrane (GO:0006612)2.64559736
137response to interferon-beta (GO:0035456)2.63321349
138regulation of mitochondrial translation (GO:0070129)2.62170493
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.60683236
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58895303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.72171116
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04863476
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83713075
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.43613688
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40742282
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32966636
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.10181363
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.99361210
9* ETS1_20019798_ChIP-Seq_JURKAT_Human2.95661110
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82994971
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76463406
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58760512
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49949575
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49356221
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36101993
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35396432
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32994749
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32630829
19VDR_23849224_ChIP-Seq_CD4+_Human2.32366414
20XRN2_22483619_ChIP-Seq_HELA_Human2.27884102
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19875926
22DCP1A_22483619_ChIP-Seq_HELA_Human2.18679814
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15132882
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13996809
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12190587
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.06695689
27GABP_19822575_ChIP-Seq_HepG2_Human2.06441466
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.05573486
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.05513835
30FOXP3_21729870_ChIP-Seq_TREG_Human2.02857181
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98211015
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96273077
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95389490
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77157796
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76195024
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74396713
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73460264
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72125419
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70806103
40TTF2_22483619_ChIP-Seq_HELA_Human1.70084796
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.68013335
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65960091
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63324606
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62422693
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.61353168
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61323475
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60942279
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60128393
49ELK1_19687146_ChIP-ChIP_HELA_Human1.58794063
50* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58229634
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57902675
52CIITA_25753668_ChIP-Seq_RAJI_Human1.50432626
53* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46029666
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45739790
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45346045
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42714563
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41783529
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40950554
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.38897635
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37299074
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35236616
62SPI1_23547873_ChIP-Seq_NB4_Human1.34559788
63MYC_22102868_ChIP-Seq_BL_Human1.33233453
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32651739
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28729141
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27157223
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25422904
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.24620589
69AR_21909140_ChIP-Seq_LNCAP_Human1.24533335
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22637226
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.22527210
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21752778
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.20044617
74TFEB_21752829_ChIP-Seq_HELA_Human1.18756087
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.17488308
76* VDR_21846776_ChIP-Seq_THP-1_Human1.15515709
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14955233
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13598610
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07853245
80ZNF274_21170338_ChIP-Seq_K562_Hela1.07758608
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07409735
82* KDM5A_27292631_Chip-Seq_BREAST_Human1.07148180
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06878377
84* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04190257
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03276335
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03185450
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00996328
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98861418
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98633559
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98374440
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97565775
92CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95149079
93MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94786873
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94331618
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93950416
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93818270
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93129985
98TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90628252
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89957198
100* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89099658
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89017876
102* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88776599
103MYC_18940864_ChIP-ChIP_HL60_Human0.87372139
104EWS_26573619_Chip-Seq_HEK293_Human0.84793200
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84538355
106* NANOG_16153702_ChIP-ChIP_HESCs_Human0.82616427
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82308068
108* SOX2_16153702_ChIP-ChIP_HESCs_Human0.82300434
109ELF5_23300383_ChIP-Seq_T47D_Human0.79552694
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78248333
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77031441
112PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76989522
113TP53_22573176_ChIP-Seq_HFKS_Human0.75671819
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.73420963
115IRF1_19129219_ChIP-ChIP_H3396_Human0.72876916
116* FOXP1_21924763_ChIP-Seq_HESCs_Human0.72334009
117VDR_22108803_ChIP-Seq_LS180_Human0.72112156
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71254418
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70036734
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.66884549
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66277985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.82275267
2MP0004957_abnormal_blastocyst_morpholog3.23682596
3MP0003077_abnormal_cell_cycle2.81596669
4MP0002254_reproductive_system_inflammat2.69126772
5MP0010094_abnormal_chromosome_stability2.61453310
6MP0008007_abnormal_cellular_replicative2.59973547
7MP0003111_abnormal_nucleus_morphology2.57060674
8MP0002102_abnormal_ear_morphology2.49383783
9MP0002396_abnormal_hematopoietic_system2.35355067
10MP0008058_abnormal_DNA_repair2.34672204
11MP0001835_abnormal_antigen_presentation2.33442709
12MP0003186_abnormal_redox_activity2.32079217
13MP0009333_abnormal_splenocyte_physiolog2.19007722
14MP0006292_abnormal_olfactory_placode2.03551525
15MP0001529_abnormal_vocalization2.02708499
16MP0003806_abnormal_nucleotide_metabolis2.02097441
17MP0009785_altered_susceptibility_to1.99796145
18MP0002938_white_spotting1.98969006
19MP0002277_abnormal_respiratory_mucosa1.96927098
20MP0000490_abnormal_crypts_of1.89933407
21MP0001853_heart_inflammation1.89826376
22MP0006054_spinal_hemorrhage1.86892013
23MP0005397_hematopoietic_system_phenotyp1.84240440
24MP0001545_abnormal_hematopoietic_system1.84240440
25MP0000685_abnormal_immune_system1.83319057
26MP0008995_early_reproductive_senescence1.81389102
27MP0008057_abnormal_DNA_replication1.78222236
28MP0008932_abnormal_embryonic_tissue1.75943115
29MP0002132_abnormal_respiratory_system1.72699638
30MP0000858_altered_metastatic_potential1.65073742
31MP0003763_abnormal_thymus_physiology1.64315375
32MP0002148_abnormal_hypersensitivity_rea1.62690898
33MP0003436_decreased_susceptibility_to1.62365766
34MP0005671_abnormal_response_to1.61768214
35MP0002163_abnormal_gland_morphology1.61225841
36MP0002837_dystrophic_cardiac_calcinosis1.58228672
37MP0002398_abnormal_bone_marrow1.57165537
38MP0008877_abnormal_DNA_methylation1.55655806
39MP0003786_premature_aging1.55261952
40MP0001986_abnormal_taste_sensitivity1.54712451
41MP0009379_abnormal_foot_pigmentation1.52111768
42MP0006036_abnormal_mitochondrial_physio1.50867033
43MP0005025_abnormal_response_to1.49248416
44MP0004808_abnormal_hematopoietic_stem1.47289260
45MP0006072_abnormal_retinal_apoptosis1.47221214
46MP0008789_abnormal_olfactory_epithelium1.46922592
47MP0000689_abnormal_spleen_morphology1.45246660
48MP0002736_abnormal_nociception_after1.41641243
49MP0008875_abnormal_xenobiotic_pharmacok1.40873455
50MP0003724_increased_susceptibility_to1.40687946
51MP0003656_abnormal_erythrocyte_physiolo1.39903958
52MP0002722_abnormal_immune_system1.39493725
53MP0002405_respiratory_system_inflammati1.36910203
54MP0002452_abnormal_antigen_presenting1.35984334
55MP0002019_abnormal_tumor_incidence1.34936858
56MP0003195_calcinosis1.34610996
57MP0005000_abnormal_immune_tolerance1.33695677
58MP0001800_abnormal_humoral_immune1.33602281
59MP0002429_abnormal_blood_cell1.33105907
60MP0002420_abnormal_adaptive_immunity1.32146818
61MP0001819_abnormal_immune_cell1.31621582
62MP0000716_abnormal_immune_system1.26987317
63MP0000350_abnormal_cell_proliferation1.26829002
64MP0002723_abnormal_immune_serum1.25784559
65MP0000313_abnormal_cell_death1.21558375
66MP0008872_abnormal_physiological_respon1.19930275
67MP0001730_embryonic_growth_arrest1.19334887
68MP0002419_abnormal_innate_immunity1.18063904
69MP0003646_muscle_fatigue1.17255218
70MP0001293_anophthalmia1.17001139
71MP0003011_delayed_dark_adaptation1.16758180
72MP0004147_increased_porphyrin_level1.15729053
73MP0003718_maternal_effect1.14506815
74MP0000343_altered_response_to1.12826440
75MP0000358_abnormal_cell_content/1.12488752
76MP0001790_abnormal_immune_system1.11788393
77MP0005387_immune_system_phenotype1.11788393
78MP0000703_abnormal_thymus_morphology1.11786671
79MP0003123_paternal_imprinting1.08306882
80MP0010352_gastrointestinal_tract_polyps1.08030194
81MP0000465_gastrointestinal_hemorrhage1.07291081
82MP0004133_heterotaxia1.05135429
83MP0005464_abnormal_platelet_physiology1.02150493
84MP0001845_abnormal_inflammatory_respons1.01666341
85MP0002210_abnormal_sex_determination1.01322357
86MP0002234_abnormal_pharynx_morphology0.99881812
87MP0000516_abnormal_urinary_system0.98082510
88MP0005367_renal/urinary_system_phenotyp0.98082510
89MP0001905_abnormal_dopamine_level0.97605519
90MP0005075_abnormal_melanosome_morpholog0.97064047
91MP0008469_abnormal_protein_level0.96243133
92MP0005332_abnormal_amino_acid0.96233158
93MP0005379_endocrine/exocrine_gland_phen0.96096579
94MP0001929_abnormal_gametogenesis0.94690500
95MP0010155_abnormal_intestine_physiology0.93630185
96MP0002080_prenatal_lethality0.93227629
97MP0005389_reproductive_system_phenotype0.92053682
98MP0005645_abnormal_hypothalamus_physiol0.91522696
99MP0004782_abnormal_surfactant_physiolog0.91305675
100MP0001697_abnormal_embryo_size0.89979582
101MP0005636_abnormal_mineral_homeostasis0.89865573
102MP0005084_abnormal_gallbladder_morpholo0.89756282
103MP0003567_abnormal_fetal_cardiomyocyte0.88779279
104MP0000653_abnormal_sex_gland0.88162060
105MP0002751_abnormal_autonomic_nervous0.87419902
106MP0003221_abnormal_cardiomyocyte_apopto0.87324625
107MP0001119_abnormal_female_reproductive0.86094844
108MP0001145_abnormal_male_reproductive0.85870359
109MP0009840_abnormal_foam_cell0.84916103
110MP0001542_abnormal_bone_strength0.84915364
111MP0006082_CNS_inflammation0.84547883
112MP0005395_other_phenotype0.84350850
113MP0003315_abnormal_perineum_morphology0.83441776
114MP0008873_increased_physiological_sensi0.82947965
115MP0003136_yellow_coat_color0.80508153
116MP0001533_abnormal_skeleton_physiology0.78926024
117MP0005253_abnormal_eye_physiology0.78594644
118MP0005174_abnormal_tail_pigmentation0.78438265
119MP0006035_abnormal_mitochondrial_morpho0.78170099
120MP0002006_tumorigenesis0.77101194
121MP0005394_taste/olfaction_phenotype0.76938479
122MP0005499_abnormal_olfactory_system0.76938479
123MP0001764_abnormal_homeostasis0.75598587
124MP0003279_aneurysm0.75294072
125MP0005023_abnormal_wound_healing0.75056432
126MP0010368_abnormal_lymphatic_system0.74538290
127MP0005410_abnormal_fertilization0.73650444
128MP0009697_abnormal_copulation0.72934860
129MP0002166_altered_tumor_susceptibility0.71613226
130MP0001919_abnormal_reproductive_system0.71183604
131MP0001968_abnormal_touch/_nociception0.69481241
132MP0000749_muscle_degeneration0.69313776
133MP0003941_abnormal_skin_development0.69200330
134MP0002138_abnormal_hepatobiliary_system0.68173874
135MP0005384_cellular_phenotype0.67198167
136MP0000372_irregular_coat_pigmentation0.66734122
137MP0000598_abnormal_liver_morphology0.66157024
138MP0010307_abnormal_tumor_latency0.65493390
139MP0005551_abnormal_eye_electrophysiolog0.65383329
140MP0002095_abnormal_skin_pigmentation0.64922581
141MP0001346_abnormal_lacrimal_gland0.64762600
142MP0010030_abnormal_orbit_morphology0.64703805
143MP0001727_abnormal_embryo_implantation0.64117572
144MP0002160_abnormal_reproductive_system0.63459333
145MP0005621_abnormal_cell_physiology0.63060340
146MP0005266_abnormal_metabolism0.63013271
147MP0001873_stomach_inflammation0.62519120
148MP0005408_hypopigmentation0.61572459
149MP0002653_abnormal_ependyma_morphology0.61375163
150MP0000613_abnormal_salivary_gland0.60807079
151MP0001485_abnormal_pinna_reflex0.60418271
152MP0003119_abnormal_digestive_system0.57495294

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.54635388
2Abnormal number of erythroid precursors (HP:0012131)4.52996338
3Reticulocytopenia (HP:0001896)4.33556881
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.14191720
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.14191720
6Aplastic anemia (HP:0001915)3.94750271
7Cerebral edema (HP:0002181)3.58494590
8Birth length less than 3rd percentile (HP:0003561)3.40354898
9Type I transferrin isoform profile (HP:0003642)3.25595158
10Methylmalonic acidemia (HP:0002912)3.25205059
11Thrombocytosis (HP:0001894)3.21568400
12Methylmalonic aciduria (HP:0012120)3.19051861
13Oral leukoplakia (HP:0002745)3.15154761
14Hepatocellular necrosis (HP:0001404)3.12628023
15Microretrognathia (HP:0000308)3.09473230
16Hepatic necrosis (HP:0002605)3.08250735
17Abnormality of the anterior horn cell (HP:0006802)3.06459727
18Degeneration of anterior horn cells (HP:0002398)3.06459727
19Reduced antithrombin III activity (HP:0001976)3.06441782
20Microvesicular hepatic steatosis (HP:0001414)2.94864593
21Aplasia/Hypoplasia of the sacrum (HP:0008517)2.91163738
22Pallor (HP:0000980)2.83808610
23Mitochondrial inheritance (HP:0001427)2.80770958
24Increased serum lactate (HP:0002151)2.80546474
25Exertional dyspnea (HP:0002875)2.77356780
26Macrocytic anemia (HP:0001972)2.73155707
27Elevated erythrocyte sedimentation rate (HP:0003565)2.71488006
28Rough bone trabeculation (HP:0100670)2.69126827
29Increased CSF lactate (HP:0002490)2.68380925
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67163239
31Abnormal protein glycosylation (HP:0012346)2.62723629
32Abnormal glycosylation (HP:0012345)2.62723629
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.62723629
34Abnormal protein N-linked glycosylation (HP:0012347)2.62723629
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.62023850
36Poor head control (HP:0002421)2.61399808
37Petechiae (HP:0000967)2.60721354
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59196629
39Abnormality of alanine metabolism (HP:0010916)2.59196629
40Hyperalaninemia (HP:0003348)2.59196629
41Lethargy (HP:0001254)2.57010109
42Abnormal mitochondria in muscle tissue (HP:0008316)2.54033293
43Increased hepatocellular lipid droplets (HP:0006565)2.51438090
44Optic disc pallor (HP:0000543)2.51288727
45Acute necrotizing encephalopathy (HP:0006965)2.48462244
46Lipid accumulation in hepatocytes (HP:0006561)2.46854880
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44422703
48Multiple enchondromatosis (HP:0005701)2.40883337
49Abnormality of methionine metabolism (HP:0010901)2.38996904
50Leukodystrophy (HP:0002415)2.38940466
51CNS demyelination (HP:0007305)2.38261323
52Breast hypoplasia (HP:0003187)2.37300277
533-Methylglutaconic aciduria (HP:0003535)2.37159880
54Lactic acidosis (HP:0003128)2.36515049
55Increased serum pyruvate (HP:0003542)2.35923947
56Vertebral compression fractures (HP:0002953)2.35466518
57Muscle fiber atrophy (HP:0100295)2.34164996
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33937233
59Dicarboxylic aciduria (HP:0003215)2.33937233
60Type 2 muscle fiber atrophy (HP:0003554)2.32184176
61Increased intramyocellular lipid droplets (HP:0012240)2.32036091
62IgM deficiency (HP:0002850)2.30936299
63Hyperglycinemia (HP:0002154)2.28840770
64Trismus (HP:0000211)2.28146908
65Abnormality of renal resorption (HP:0011038)2.23270553
66Increased muscle lipid content (HP:0009058)2.20811507
67Pancytopenia (HP:0001876)2.20235870
68Abnormality of urine glucose concentration (HP:0011016)2.18567033
69Glycosuria (HP:0003076)2.18567033
70Carpal bone hypoplasia (HP:0001498)2.17895984
71Pancreatic cysts (HP:0001737)2.17893934
72Respiratory difficulties (HP:0002880)2.17147738
73Abnormality of glycolysis (HP:0004366)2.17097838
74Exercise intolerance (HP:0003546)2.16229399
7511 pairs of ribs (HP:0000878)2.15949873
76Myositis (HP:0100614)2.15841633
77Abnormality of serum amino acid levels (HP:0003112)2.13825230
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13408936
79Absent thumb (HP:0009777)2.11811993
80Nausea (HP:0002018)2.09291358
81Acute encephalopathy (HP:0006846)2.07276568
82Premature graying of hair (HP:0002216)2.07237079
83Selective tooth agenesis (HP:0001592)2.04576719
84Recurrent abscess formation (HP:0002722)2.02125347
85Patellar aplasia (HP:0006443)2.01917563
86Colon cancer (HP:0003003)2.00571733
87Progressive muscle weakness (HP:0003323)1.97285875
88Bone marrow hypocellularity (HP:0005528)1.95953168
89Abnormality of the pons (HP:0007361)1.95573142
90Aplasia/Hypoplasia of the patella (HP:0006498)1.95452644
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.94907312
92Emotional lability (HP:0000712)1.92133323
93Hypoglycemic coma (HP:0001325)1.90446873
94Testicular atrophy (HP:0000029)1.90432600
95Abnormal trabecular bone morphology (HP:0100671)1.90384444
96Abnormality of placental membranes (HP:0011409)1.89807970
97Amniotic constriction ring (HP:0009775)1.89807970
98Pulmonary fibrosis (HP:0002206)1.88735621
99Cellular immunodeficiency (HP:0005374)1.88518814
100Hypoplasia of the pons (HP:0012110)1.88093335
101Myelodysplasia (HP:0002863)1.87717168
102Generalized aminoaciduria (HP:0002909)1.86440783
103Cerebral hypomyelination (HP:0006808)1.86422782
104Cleft eyelid (HP:0000625)1.86299870
105Renal Fanconi syndrome (HP:0001994)1.85912425
106Respiratory failure (HP:0002878)1.85798319
107Pancreatic fibrosis (HP:0100732)1.82831120
108Sparse eyelashes (HP:0000653)1.82230025
109Abnormality of T cell physiology (HP:0011840)1.82178147
110Neutropenia (HP:0001875)1.81724618
111Secondary amenorrhea (HP:0000869)1.80452004
112X-linked dominant inheritance (HP:0001423)1.79935056
113Hypothermia (HP:0002045)1.79739473
114Abnormality of the vitamin B12 metabolism (HP:0004341)1.78666277
115Hyperinsulinemic hypoglycemia (HP:0000825)1.78532713
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78114208
117Abnormality of chromosome stability (HP:0003220)1.76563053
118Poikiloderma (HP:0001029)1.76531355
119Atrophy/Degeneration involving motor neurons (HP:0007373)1.76468901
120True hermaphroditism (HP:0010459)1.76238418
121Neoplasm of the adrenal gland (HP:0100631)1.75902648
122Beaking of vertebral bodies (HP:0004568)1.75432228
123Dry hair (HP:0011359)1.74281458
124Abnormality of reticulocytes (HP:0004312)1.72598382
125Sclerocornea (HP:0000647)1.72104938
126Abnormality of the labia minora (HP:0012880)1.71757015
127Abnormality of homocysteine metabolism (HP:0010919)1.71632010
128Homocystinuria (HP:0002156)1.71632010
129Abnormality of vitamin B metabolism (HP:0004340)1.70894557
130Progressive macrocephaly (HP:0004481)1.70274682
131Lymphoma (HP:0002665)1.70153903
132Ketoacidosis (HP:0001993)1.69928040
133Slender long bone (HP:0003100)1.69926077
134Abnormal biliary tract physiology (HP:0012439)1.68049151
135Bile duct proliferation (HP:0001408)1.68049151
136Neoplasm of the pancreas (HP:0002894)1.65704747
137Recurrent bacterial skin infections (HP:0005406)1.65268375
138Optic nerve coloboma (HP:0000588)1.62627937
139Meckel diverticulum (HP:0002245)1.62357029
140Rhabdomyolysis (HP:0003201)1.60771532
141Abnormality of the preputium (HP:0100587)1.60558471
142Chronic otitis media (HP:0000389)1.59151367
143Abnormality of the ileum (HP:0001549)1.59078639
144Biconcave vertebral bodies (HP:0004586)1.59018306
145Premature ovarian failure (HP:0008209)1.58351164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.06151587
2BUB13.71318899
3NME23.59891812
4WEE13.00229537
5EIF2AK12.88519962
6STK162.84912702
7TRIM282.69904269
8PIM22.61253614
9KDR2.20983224
10NUAK12.11889829
11ACVR1B2.09252224
12BCKDK1.99300076
13TESK21.96623289
14EIF2AK31.94791629
15BRSK21.92353756
16MAP4K21.91470629
17RPS6KA41.84754233
18VRK11.83863078
19DYRK31.81719069
20PLK31.78230894
21TESK11.72305285
22MAPKAPK31.67010681
23MAP4K11.65837294
24PLK41.57240278
25MAP3K111.53565489
26PDK21.53018934
27BRAF1.45807052
28FLT31.44929014
29TBK11.44706940
30ARAF1.44587089
31NEK21.38006712
32TGFBR11.33405159
33IRAK41.29768113
34TAF11.29351216
35MAP2K31.27764551
36TLK11.24702776
37CSNK1G31.22343620
38RPS6KB21.21965155
39ZAK1.20513194
40MAP3K121.19874820
41NEK11.19619416
42LRRK21.17839132
43KIT1.17735610
44CDK81.17513397
45TYK21.17271198
46MYLK1.17175224
47CDK71.16305661
48GRK11.15847380
49AURKB1.14814554
50PLK11.13367958
51IRAK31.12937670
52BRSK11.11551198
53WNK31.09477424
54PASK1.07881831
55JAK31.06777138
56DAPK11.06410547
57SCYL21.06248079
58CDC71.04859158
59MAP3K81.04087798
60CSNK1G11.03887657
61TEC1.02837059
62ZAP701.02735562
63FRK1.01000429
64AURKA1.00616270
65NME11.00045153
66MKNK10.99897424
67BLK0.99750332
68RAF10.99531578
69PIM10.98551153
70STK100.98418587
71SRPK10.97842831
72PBK0.97638016
73ILK0.95550362
74BTK0.94079604
75BCR0.92482483
76MKNK20.92475593
77IKBKE0.91721497
78LIMK10.90844051
79IKBKB0.89542182
80PIK3CG0.88673342
81ERN10.88596337
82PAK40.87296102
83CSNK1A1L0.86757278
84CSNK1G20.86480690
85ADRBK20.86096519
86MAP3K30.84137852
87ATR0.83841444
88NEK90.77352099
89STK38L0.77195651
90ABL20.76001727
91EIF2AK20.75048490
92TTK0.74780582
93CCNB10.72471777
94INSRR0.71687408
95SIK30.70835732
96NLK0.69958114
97EEF2K0.69505849
98TXK0.68225172
99CHEK20.66768313
100TAOK20.64765385
101PAK10.64318855
102CDK190.62052084
103CSNK2A20.61054626
104STK40.59914807
105MST40.59057306
106DAPK30.58560274
107DYRK20.55532280
108OXSR10.55460207
109MOS0.53760316
110RPS6KA50.53024344
111CSNK2A10.52954715
112CDK40.52075763
113MAPK110.51960191
114BMPR1B0.51545516
115TIE10.48103814
116CHUK0.47923609
117MUSK0.47441322
118TSSK60.46286631
119SYK0.46154065
120CLK10.46066330
121MAPKAPK20.44712446
122TNIK0.44284152
123PRKCI0.41608118
124LYN0.40725785
125MARK30.40248582
126CHEK10.39894710
127MAP3K100.38105499
128MAP2K70.35643840
129PLK20.34941373
130ATM0.34326858
131MAP2K60.32153725
132CSNK1A10.30655792
133CDK30.28373125
134MAPKAPK50.26573706
135PRKCG0.24036252
136ADRBK10.18150175

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.33410976
2Proteasome_Homo sapiens_hsa030504.16854841
3DNA replication_Homo sapiens_hsa030303.97663957
4RNA polymerase_Homo sapiens_hsa030203.28999837
5Mismatch repair_Homo sapiens_hsa034303.05966157
6Base excision repair_Homo sapiens_hsa034102.79080671
7Pyrimidine metabolism_Homo sapiens_hsa002402.64345983
8Protein export_Homo sapiens_hsa030602.53193927
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48780214
10Spliceosome_Homo sapiens_hsa030402.34515566
11Homologous recombination_Homo sapiens_hsa034402.27571255
12Nucleotide excision repair_Homo sapiens_hsa034202.26498001
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05944722
14* RNA transport_Homo sapiens_hsa030131.91824966
15Cell cycle_Homo sapiens_hsa041101.87379154
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65138063
17Parkinsons disease_Homo sapiens_hsa050121.60145793
18Non-homologous end-joining_Homo sapiens_hsa034501.55415925
19RNA degradation_Homo sapiens_hsa030181.50090976
20Oxidative phosphorylation_Homo sapiens_hsa001901.49660599
21Fatty acid elongation_Homo sapiens_hsa000621.47543747
22Folate biosynthesis_Homo sapiens_hsa007901.47075185
23One carbon pool by folate_Homo sapiens_hsa006701.42133302
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40727216
25Basal transcription factors_Homo sapiens_hsa030221.39577398
26Sulfur relay system_Homo sapiens_hsa041221.38274552
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35599347
28p53 signaling pathway_Homo sapiens_hsa041151.34530443
29Purine metabolism_Homo sapiens_hsa002301.34277472
30Fanconi anemia pathway_Homo sapiens_hsa034601.29873109
31Huntingtons disease_Homo sapiens_hsa050161.29666407
32Propanoate metabolism_Homo sapiens_hsa006401.22275576
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20358868
34Legionellosis_Homo sapiens_hsa051341.17431426
35Epstein-Barr virus infection_Homo sapiens_hsa051691.14387987
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13256992
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11948312
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11564832
39Pentose phosphate pathway_Homo sapiens_hsa000301.10825924
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10658355
41Pyruvate metabolism_Homo sapiens_hsa006201.08386385
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03019355
43Cardiac muscle contraction_Homo sapiens_hsa042601.02776043
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99295522
45Herpes simplex infection_Homo sapiens_hsa051680.98876779
46Antigen processing and presentation_Homo sapiens_hsa046120.97639182
47Vitamin B6 metabolism_Homo sapiens_hsa007500.95158577
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.89894565
49Peroxisome_Homo sapiens_hsa041460.86711548
50Glutathione metabolism_Homo sapiens_hsa004800.86337811
51Primary immunodeficiency_Homo sapiens_hsa053400.85323673
52Sulfur metabolism_Homo sapiens_hsa009200.84348577
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83983201
54Leishmaniasis_Homo sapiens_hsa051400.83556391
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80619065
56Other glycan degradation_Homo sapiens_hsa005110.80206050
57N-Glycan biosynthesis_Homo sapiens_hsa005100.77963771
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77723007
59Shigellosis_Homo sapiens_hsa051310.76110123
60Galactose metabolism_Homo sapiens_hsa000520.75254381
61Measles_Homo sapiens_hsa051620.74997801
62Steroid biosynthesis_Homo sapiens_hsa001000.74138949
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.71570405
64Butanoate metabolism_Homo sapiens_hsa006500.70965694
65Selenocompound metabolism_Homo sapiens_hsa004500.69601603
66Apoptosis_Homo sapiens_hsa042100.69161133
67Alzheimers disease_Homo sapiens_hsa050100.68319673
68Fructose and mannose metabolism_Homo sapiens_hsa000510.66855715
69Collecting duct acid secretion_Homo sapiens_hsa049660.66250512
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.66214488
71Allograft rejection_Homo sapiens_hsa053300.65760955
72Biosynthesis of amino acids_Homo sapiens_hsa012300.65657776
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.65418856
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.63713837
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62510883
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61727886
77Thyroid cancer_Homo sapiens_hsa052160.61165398
78Carbon metabolism_Homo sapiens_hsa012000.59931901
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57534896
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56528347
81Hematopoietic cell lineage_Homo sapiens_hsa046400.56075257
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53847811
83Viral carcinogenesis_Homo sapiens_hsa052030.53754676
84Systemic lupus erythematosus_Homo sapiens_hsa053220.53168257
85Influenza A_Homo sapiens_hsa051640.53114931
86Regulation of autophagy_Homo sapiens_hsa041400.52666566
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51537306
88mRNA surveillance pathway_Homo sapiens_hsa030150.49858353
89HTLV-I infection_Homo sapiens_hsa051660.46253039
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44988753
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44935094
92Hepatitis B_Homo sapiens_hsa051610.44069541
93Tryptophan metabolism_Homo sapiens_hsa003800.43969781
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43500922
95Metabolic pathways_Homo sapiens_hsa011000.43015880
96Asthma_Homo sapiens_hsa053100.42817953
97Caffeine metabolism_Homo sapiens_hsa002320.42378403
98Malaria_Homo sapiens_hsa051440.41542459
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41126653
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38603746
101Fatty acid metabolism_Homo sapiens_hsa012120.38430570
102Vitamin digestion and absorption_Homo sapiens_hsa049770.38385282
103Type I diabetes mellitus_Homo sapiens_hsa049400.38313868
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.38288123
105Pertussis_Homo sapiens_hsa051330.38203654
106Phototransduction_Homo sapiens_hsa047440.37591776
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37545328
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37177117
109Graft-versus-host disease_Homo sapiens_hsa053320.34473126
110Arachidonic acid metabolism_Homo sapiens_hsa005900.34104918
111beta-Alanine metabolism_Homo sapiens_hsa004100.33313988
112Acute myeloid leukemia_Homo sapiens_hsa052210.33058877
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32244517
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.31041484
115Oocyte meiosis_Homo sapiens_hsa041140.30089626
116Chemical carcinogenesis_Homo sapiens_hsa052040.29517456
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29079567
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.28945508
119Linoleic acid metabolism_Homo sapiens_hsa005910.28677714
120Fatty acid degradation_Homo sapiens_hsa000710.26806311
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26659340
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26416324
123Rheumatoid arthritis_Homo sapiens_hsa053230.25773358
124Autoimmune thyroid disease_Homo sapiens_hsa053200.24623547
125Bladder cancer_Homo sapiens_hsa052190.24573025
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23660310
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23553697
128Arginine and proline metabolism_Homo sapiens_hsa003300.22519395
129Tuberculosis_Homo sapiens_hsa051520.22176399
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21994272
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21569665
132Small cell lung cancer_Homo sapiens_hsa052220.20958134
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20020741
134HIF-1 signaling pathway_Homo sapiens_hsa040660.19620270
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19350371
136TNF signaling pathway_Homo sapiens_hsa046680.18633135

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