GEMIN8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)6.17948041
2doxorubicin metabolic process (GO:0044598)6.17948041
3daunorubicin metabolic process (GO:0044597)6.17948041
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.76546956
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.30156660
6ATP synthesis coupled proton transport (GO:0015986)4.78005762
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.78005762
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.38385194
9viral transcription (GO:0019083)4.29406519
10translational termination (GO:0006415)4.20407233
11chaperone-mediated protein transport (GO:0072321)4.13189769
12protein complex biogenesis (GO:0070271)4.11874801
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.08856480
14cotranslational protein targeting to membrane (GO:0006613)4.06344458
15respiratory electron transport chain (GO:0022904)4.01468639
16protein targeting to ER (GO:0045047)3.95174564
17electron transport chain (GO:0022900)3.94747094
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92251993
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.92251993
20NADH dehydrogenase complex assembly (GO:0010257)3.92251993
21mitochondrial respiratory chain complex assembly (GO:0033108)3.89283266
22base-excision repair, AP site formation (GO:0006285)3.85598332
23establishment of protein localization to endoplasmic reticulum (GO:0072599)3.80391365
24protein-cofactor linkage (GO:0018065)3.79234713
25protein localization to endoplasmic reticulum (GO:0070972)3.77801701
26DNA double-strand break processing (GO:0000729)3.77606922
27regulation of mitochondrial translation (GO:0070129)3.73795667
28aminoglycoside antibiotic metabolic process (GO:0030647)3.73393706
29translational elongation (GO:0006414)3.71704865
30cullin deneddylation (GO:0010388)3.67532378
31intraciliary transport (GO:0042073)3.61618415
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59730141
33inner mitochondrial membrane organization (GO:0007007)3.58134496
34centriole assembly (GO:0098534)3.53761667
35kinetochore assembly (GO:0051382)3.50031780
36water-soluble vitamin biosynthetic process (GO:0042364)3.49458133
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.46632392
38translational initiation (GO:0006413)3.40517064
39platelet dense granule organization (GO:0060155)3.40478360
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36844640
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35768849
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.33008877
43protein deneddylation (GO:0000338)3.30697264
44viral life cycle (GO:0019058)3.30610413
45intracellular protein transmembrane import (GO:0044743)3.29634071
46DNA deamination (GO:0045006)3.27146777
47establishment of integrated proviral latency (GO:0075713)3.26693848
48cellular protein complex disassembly (GO:0043624)3.26280413
49translation (GO:0006412)3.24890614
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22863444
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17861064
52negative regulation of ligase activity (GO:0051352)3.17861064
53telomere maintenance via telomerase (GO:0007004)3.15208386
54mesenchymal cell differentiation involved in kidney development (GO:0072161)3.14785679
55mesenchymal cell differentiation involved in renal system development (GO:2001012)3.14785679
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14229825
57tRNA methylation (GO:0030488)3.12157919
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11538693
59oxidative phosphorylation (GO:0006119)3.10445759
60kinetochore organization (GO:0051383)3.09969099
61energy homeostasis (GO:0097009)3.05174002
62DNA catabolic process, exonucleolytic (GO:0000738)3.04598395
63superoxide anion generation (GO:0042554)3.03541079
64protein neddylation (GO:0045116)3.00661445
65CENP-A containing nucleosome assembly (GO:0034080)2.97089321
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97043381
67microtubule depolymerization (GO:0007019)2.96553779
68RNA-dependent DNA replication (GO:0006278)2.95941516
69regulation of cellular amino acid metabolic process (GO:0006521)2.95896540
70ribosomal small subunit biogenesis (GO:0042274)2.94521179
71cellular component biogenesis (GO:0044085)2.91938198
72peptidyl-histidine modification (GO:0018202)2.89973632
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89745419
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89745419
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89745419
76purine nucleobase biosynthetic process (GO:0009113)2.89674426
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86806211
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86806211
79telomere maintenance via semi-conservative replication (GO:0032201)2.85763568
80chromatin remodeling at centromere (GO:0031055)2.84251016
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83685890
82protein complex disassembly (GO:0043241)2.82792905
83establishment of viral latency (GO:0019043)2.81056575
84regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80450335
85regulation of mitotic spindle checkpoint (GO:1903504)2.80450335
86ATP biosynthetic process (GO:0006754)2.80170587
87hydrogen ion transmembrane transport (GO:1902600)2.79887869
88regulation of double-strand break repair via homologous recombination (GO:0010569)2.79711872
89proteasome assembly (GO:0043248)2.79526077
90DNA ligation (GO:0006266)2.79394798
91ribosomal small subunit assembly (GO:0000028)2.78369870
92organelle disassembly (GO:1903008)2.78114835
93signal transduction involved in DNA damage checkpoint (GO:0072422)2.77985789
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77985789
95nucleobase biosynthetic process (GO:0046112)2.77253868
96macromolecular complex disassembly (GO:0032984)2.76859170
97telomere maintenance via telomere lengthening (GO:0010833)2.76432488
98signal transduction involved in cell cycle checkpoint (GO:0072395)2.75872499
99telomere maintenance via recombination (GO:0000722)2.74630149
100purine nucleoside triphosphate biosynthetic process (GO:0009145)2.73143534
101epithelial cilium movement (GO:0003351)2.72347848
102viral mRNA export from host cell nucleus (GO:0046784)2.71656385
103regulation of cilium movement (GO:0003352)2.71520276
104positive regulation of ligase activity (GO:0051351)2.70032537
105ubiquinone biosynthetic process (GO:0006744)2.69660852
106protein targeting to mitochondrion (GO:0006626)2.67599472
107protein K6-linked ubiquitination (GO:0085020)2.67059776
108DNA replication checkpoint (GO:0000076)2.65114360
109respiratory chain complex IV assembly (GO:0008535)2.63127059
110DNA strand renaturation (GO:0000733)2.61695808
111replicative senescence (GO:0090399)2.61457341
112DNA synthesis involved in DNA repair (GO:0000731)2.60504532
113centriole replication (GO:0007099)2.57956436
114DNA replication initiation (GO:0006270)2.56249749
115negative regulation of telomere maintenance (GO:0032205)2.54903284
116DNA integration (GO:0015074)2.54884399
117meiotic chromosome segregation (GO:0045132)2.53078961
118adenosine metabolic process (GO:0046085)2.52136068
119cell differentiation involved in metanephros development (GO:0072202)2.49772816
120intra-S DNA damage checkpoint (GO:0031573)2.49726761
121termination of RNA polymerase I transcription (GO:0006363)2.48157891
122mitotic recombination (GO:0006312)2.46917424
123DNA strand elongation (GO:0022616)2.45766666
124lymphoid progenitor cell differentiation (GO:0002320)2.45734919
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43829167
126transcription elongation from RNA polymerase III promoter (GO:0006385)2.41614992
127termination of RNA polymerase III transcription (GO:0006386)2.41614992
128transcription elongation from RNA polymerase I promoter (GO:0006362)2.41527191
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40581481
130GPI anchor biosynthetic process (GO:0006506)2.39848483
131pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.38767058
132maturation of 5.8S rRNA (GO:0000460)2.38629965
133preassembly of GPI anchor in ER membrane (GO:0016254)2.38512427
134cytochrome complex assembly (GO:0017004)2.38048002
135maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.37451893
136tRNA modification (GO:0006400)2.36638330
137rRNA modification (GO:0000154)2.35756905
138mesonephros development (GO:0001823)2.35371058
139regulation of timing of cell differentiation (GO:0048505)2.34322083
140RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.33984753
141tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.33984753
142rRNA methylation (GO:0031167)2.32348586
143auditory receptor cell stereocilium organization (GO:0060088)2.32322828
144detection of molecule of bacterial origin (GO:0032490)2.32251811
145DNA damage response, detection of DNA damage (GO:0042769)2.32157437
146pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.31010233
147mismatch repair (GO:0006298)2.30272649
148positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.29455364
1497-methylguanosine RNA capping (GO:0009452)2.28752990
150RNA capping (GO:0036260)2.28752990
151DNA strand elongation involved in DNA replication (GO:0006271)2.28447000
152DNA replication-independent nucleosome organization (GO:0034724)2.27827775
153DNA replication-independent nucleosome assembly (GO:0006336)2.27827775
1547-methylguanosine mRNA capping (GO:0006370)2.26045365
155pseudouridine synthesis (GO:0001522)2.25228957
156GTP biosynthetic process (GO:0006183)2.25086637
157RNA methylation (GO:0001510)2.24704408
158female gonad development (GO:0008585)2.23943552
159C-terminal protein lipidation (GO:0006501)2.23859377
160maturation of SSU-rRNA (GO:0030490)2.23201189
161tRNA processing (GO:0008033)2.22170898
162mannosylation (GO:0097502)2.21873645
163deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.20890771
164negative regulation of mast cell activation (GO:0033004)2.19796595
165motile cilium assembly (GO:0044458)2.18210562
166histone H2A acetylation (GO:0043968)2.18154831
167regulation of development, heterochronic (GO:0040034)2.17857962
168telomere maintenance (GO:0000723)2.17417229
169pyrimidine dimer repair (GO:0006290)2.17177950
170ribosomal large subunit biogenesis (GO:0042273)2.17004378
171cell proliferation in forebrain (GO:0021846)2.16653966
172DNA methylation involved in gamete generation (GO:0043046)2.16421048
173transcription-coupled nucleotide-excision repair (GO:0006283)2.15831359
174telomere organization (GO:0032200)2.15357570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.06619096
2E2F7_22180533_ChIP-Seq_HELA_Human4.32551157
3CREB1_15753290_ChIP-ChIP_HEK293T_Human3.41935121
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.25127645
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.16342249
6GBX2_23144817_ChIP-Seq_PC3_Human2.98779212
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.67270201
8EZH2_22144423_ChIP-Seq_EOC_Human2.63265992
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.49063309
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.41742512
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36491555
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35096227
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33779588
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27680098
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26107488
16ZNF274_21170338_ChIP-Seq_K562_Hela2.25352511
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18007561
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.14698552
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13554721
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13541263
21NFE2_27457419_Chip-Seq_LIVER_Mouse2.12069209
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09252665
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08577695
24PCGF2_27294783_Chip-Seq_NPCs_Mouse2.03081671
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97447099
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96239249
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.95042561
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94049001
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.93343162
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93324616
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89711491
32* TTF2_22483619_ChIP-Seq_HELA_Human1.86125758
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82413054
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80922786
35EWS_26573619_Chip-Seq_HEK293_Human1.80202689
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79977071
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78434837
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77131794
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76395169
40* GABP_19822575_ChIP-Seq_HepG2_Human1.75878433
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73392043
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.73269191
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73188157
44DCP1A_22483619_ChIP-Seq_HELA_Human1.71426276
45XRN2_22483619_ChIP-Seq_HELA_Human1.69085553
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68754498
47FUS_26573619_Chip-Seq_HEK293_Human1.66737189
48IRF1_19129219_ChIP-ChIP_H3396_Human1.66013181
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.64304828
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.61747721
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60979540
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58794875
53NMYC_18555785_Chip-Seq_ESCs_Mouse1.58088326
54* CBX2_27304074_Chip-Seq_ESCs_Mouse1.57423094
55* RNF2_27304074_Chip-Seq_NSC_Mouse1.56956374
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56831857
57IGF1R_20145208_ChIP-Seq_DFB_Human1.56418507
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56168462
59EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.54208110
60P53_22387025_ChIP-Seq_ESCs_Mouse1.53599671
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51616256
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.51115506
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.49893923
64RUNX1_27457419_Chip-Seq_LIVER_Mouse1.48203513
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48001405
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.47433150
67P300_18555785_Chip-Seq_ESCs_Mouse1.43086035
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42829760
69ZFX_18555785_Chip-Seq_ESCs_Mouse1.42465602
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.40813516
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40158103
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39924960
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38401274
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.36365669
75P300_19829295_ChIP-Seq_ESCs_Human1.36085550
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.36053737
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.35803262
78VDR_22108803_ChIP-Seq_LS180_Human1.35429826
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.34870133
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34830053
81KLF4_18555785_Chip-Seq_ESCs_Mouse1.33676330
82TAF15_26573619_Chip-Seq_HEK293_Human1.33644705
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33339670
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30748956
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.30740195
86PU1_27457419_Chip-Seq_LIVER_Mouse1.29680745
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29636588
88ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28329965
89SCL_19346495_ChIP-Seq_HPC-7_Human1.28264986
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24263715
91FOXP3_21729870_ChIP-Seq_TREG_Human1.23774853
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.22397150
93TP53_22573176_ChIP-Seq_HFKS_Human1.22278845
94CTCF_18555785_Chip-Seq_ESCs_Mouse1.20970927
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20441127
96SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19545911
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19167369
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18412820
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17448635
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16794023
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15990802
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.15760873
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.14729577
104ELK1_19687146_ChIP-ChIP_HELA_Human1.13303243
105EED_16625203_ChIP-ChIP_MESCs_Mouse1.12716388
106FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10569747
107JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10512113
108PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09889511
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09757845
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.09603566
111VDR_23849224_ChIP-Seq_CD4+_Human1.09048019
112LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08871972
113MYC_18940864_ChIP-ChIP_HL60_Human1.08737955
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08460887
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08226773
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06206311
117MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04657008
118KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03816776
119KDM5A_27292631_Chip-Seq_BREAST_Human1.03217946
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02989493
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01933276
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01540377
123CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01393834
124YY1_21170310_ChIP-Seq_MESCs_Mouse1.01004638
125SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00088442
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.99940423
127HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99921859
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99538865
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99538865
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97881729
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96622754
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96391127
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94422053
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94361675
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93696046
136IRF8_21731497_ChIP-ChIP_J774_Mouse0.93617125
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93157845
138ER_23166858_ChIP-Seq_MCF-7_Human0.93145824
139MYC_18555785_ChIP-Seq_MESCs_Mouse0.91091004
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90937253
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90136203
142SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89542390
143SALL1_21062744_ChIP-ChIP_HESCs_Human0.89240623
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89021820
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87302393
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86038516
147AR_20517297_ChIP-Seq_VCAP_Human0.85146681
148SOX17_20123909_ChIP-Seq_XEN_Mouse0.82495283
149FOXA1_25329375_ChIP-Seq_VCAP_Human0.82482783
150FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82482783
151HTT_18923047_ChIP-ChIP_STHdh_Human0.81548850
152CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81328511
153ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81192585
154CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79882551
155ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79839790
156DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79327187
157CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77231415
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76328070
159* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74806606
160NANOG_19829295_ChIP-Seq_ESCs_Human0.74765229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.90387221
2MP0001188_hyperpigmentation3.42720926
3MP0000566_synostosis2.89048743
4MP0005084_abnormal_gallbladder_morpholo2.70381097
5MP0002102_abnormal_ear_morphology2.68037556
6MP0001986_abnormal_taste_sensitivity2.56241139
7MP0008058_abnormal_DNA_repair2.49235266
8MP0005645_abnormal_hypothalamus_physiol2.31906673
9MP0003806_abnormal_nucleotide_metabolis2.27232161
10MP0003123_paternal_imprinting2.18296781
11MP0010094_abnormal_chromosome_stability2.17032167
12MP0003186_abnormal_redox_activity2.16980214
13MP0005646_abnormal_pituitary_gland2.12742741
14MP0004147_increased_porphyrin_level2.08392243
15MP0002277_abnormal_respiratory_mucosa2.07145051
16MP0002132_abnormal_respiratory_system2.04980028
17MP0003136_yellow_coat_color2.04533990
18MP0002638_abnormal_pupillary_reflex1.98253863
19MP0002653_abnormal_ependyma_morphology1.98108023
20MP0003111_abnormal_nucleus_morphology1.91693098
21MP0003941_abnormal_skin_development1.90445781
22MP0005171_absent_coat_pigmentation1.87323377
23MP0002396_abnormal_hematopoietic_system1.83807084
24MP0000015_abnormal_ear_pigmentation1.83515302
25MP0008995_early_reproductive_senescence1.78387732
26MP0004133_heterotaxia1.77323656
27MP0008057_abnormal_DNA_replication1.75731698
28MP0009697_abnormal_copulation1.67646576
29MP0006036_abnormal_mitochondrial_physio1.65759185
30MP0006035_abnormal_mitochondrial_morpho1.65756222
31MP0002938_white_spotting1.61551769
32MP0003878_abnormal_ear_physiology1.59295562
33MP0005377_hearing/vestibular/ear_phenot1.59295562
34MP0008007_abnormal_cellular_replicative1.55503860
35MP0003567_abnormal_fetal_cardiomyocyte1.54850759
36MP0002163_abnormal_gland_morphology1.54300734
37MP0005174_abnormal_tail_pigmentation1.53433198
38MP0008789_abnormal_olfactory_epithelium1.50928071
39MP0003786_premature_aging1.49139544
40MP0003693_abnormal_embryo_hatching1.47968520
41MP0008877_abnormal_DNA_methylation1.46089202
42MP0000678_abnormal_parathyroid_gland1.45901334
43MP0002736_abnormal_nociception_after1.45682757
44MP0003787_abnormal_imprinting1.45088747
45MP0004742_abnormal_vestibular_system1.45030917
46MP0005409_darkened_coat_color1.43403320
47MP0005379_endocrine/exocrine_gland_phen1.42478088
48MP0005075_abnormal_melanosome_morpholog1.42047998
49MP0005551_abnormal_eye_electrophysiolog1.40916217
50MP0004381_abnormal_hair_follicle1.40747059
51MP0004957_abnormal_blastocyst_morpholog1.40203152
52MP0001764_abnormal_homeostasis1.37975774
53MP0001529_abnormal_vocalization1.35235955
54MP0000631_abnormal_neuroendocrine_gland1.34890320
55MP0000049_abnormal_middle_ear1.34285736
56MP0003938_abnormal_ear_development1.33037657
57MP0003195_calcinosis1.32639036
58MP0002095_abnormal_skin_pigmentation1.31840978
59MP0001835_abnormal_antigen_presentation1.31063957
60MP0003011_delayed_dark_adaptation1.28348341
61MP0009379_abnormal_foot_pigmentation1.27234754
62MP0002148_abnormal_hypersensitivity_rea1.25697986
63MP0003077_abnormal_cell_cycle1.24092278
64MP0000026_abnormal_inner_ear1.20064394
65MP0003315_abnormal_perineum_morphology1.19740307
66MP0002234_abnormal_pharynx_morphology1.19509654
67MP0002837_dystrophic_cardiac_calcinosis1.15371910
68MP0001984_abnormal_olfaction1.14983910
69MP0000372_irregular_coat_pigmentation1.14196570
70MP0001929_abnormal_gametogenesis1.13031336
71MP0000490_abnormal_crypts_of1.12910913
72MP0002249_abnormal_larynx_morphology1.12563535
73MP0000516_abnormal_urinary_system1.11782884
74MP0005367_renal/urinary_system_phenotyp1.11782884
75MP0008260_abnormal_autophagy1.11226700
76MP0000778_abnormal_nervous_system1.10033766
77MP0005499_abnormal_olfactory_system1.09813852
78MP0005394_taste/olfaction_phenotype1.09813852
79MP0000613_abnormal_salivary_gland1.09812584
80MP0005671_abnormal_response_to1.08861750
81MP0000681_abnormal_thyroid_gland1.07883844
82MP0000653_abnormal_sex_gland1.05448956
83MP0001145_abnormal_male_reproductive1.03660515
84MP0001485_abnormal_pinna_reflex1.03390985
85MP0008004_abnormal_stomach_pH1.01302415
86MP0005423_abnormal_somatic_nervous1.01296436
87MP0005253_abnormal_eye_physiology1.00983795
88MP0010386_abnormal_urinary_bladder1.00631269
89MP0003880_abnormal_central_pattern0.99534011
90MP0002210_abnormal_sex_determination0.97301569
91MP0003763_abnormal_thymus_physiology0.96512254
92MP0000358_abnormal_cell_content/0.96255696
93MP0001486_abnormal_startle_reflex0.96245690
94MP0002160_abnormal_reproductive_system0.95609677
95MP0009785_altered_susceptibility_to0.94982288
96MP0003724_increased_susceptibility_to0.94077988
97MP0002282_abnormal_trachea_morphology0.93771848
98MP0001963_abnormal_hearing_physiology0.92747861
99MP0001119_abnormal_female_reproductive0.92482851
100MP0009046_muscle_twitch0.91803729
101MP0003890_abnormal_embryonic-extraembry0.91445594
102MP0001293_anophthalmia0.90573066
103MP0001186_pigmentation_phenotype0.88898257
104MP0001346_abnormal_lacrimal_gland0.87481765
105MP0000639_abnormal_adrenal_gland0.87360493
106MP0003698_abnormal_male_reproductive0.86571054
107MP0006276_abnormal_autonomic_nervous0.86075243
108MP0003121_genomic_imprinting0.85852906
109MP0005310_abnormal_salivary_gland0.83705136
110MP0002751_abnormal_autonomic_nervous0.83266221
111MP0001968_abnormal_touch/_nociception0.81459795
112MP0008932_abnormal_embryonic_tissue0.81028998
113MP0001905_abnormal_dopamine_level0.81027395
114MP0002272_abnormal_nervous_system0.80044890
115MP0005389_reproductive_system_phenotype0.79819930
116MP0006072_abnormal_retinal_apoptosis0.79278028
117MP0005332_abnormal_amino_acid0.77749974
118MP0004142_abnormal_muscle_tone0.77111414
119MP0002177_abnormal_outer_ear0.76412789
120MP0005387_immune_system_phenotype0.76240943
121MP0001790_abnormal_immune_system0.76240943
122MP0010030_abnormal_orbit_morphology0.75909864
123MP0005636_abnormal_mineral_homeostasis0.75856031
124MP0003718_maternal_effect0.74505799
125MP0002876_abnormal_thyroid_physiology0.74409275
126MP0002420_abnormal_adaptive_immunity0.73882073
127MP0001819_abnormal_immune_cell0.73755267
128MP0002928_abnormal_bile_duct0.73689912
129MP0002723_abnormal_immune_serum0.72605213
130MP0002452_abnormal_antigen_presenting0.72543223
131MP0005083_abnormal_biliary_tract0.72363920
132MP0002557_abnormal_social/conspecific_i0.72101468
133MP0001502_abnormal_circadian_rhythm0.72074936
134MP0002233_abnormal_nose_morphology0.71628664
135MP0001286_abnormal_eye_development0.71071098
136MP0002075_abnormal_coat/hair_pigmentati0.70976333
137MP0001944_abnormal_pancreas_morphology0.70318816
138MP0000647_abnormal_sebaceous_gland0.69667032
139MP0001919_abnormal_reproductive_system0.69410286
140MP0002398_abnormal_bone_marrow0.68953029
141MP0003122_maternal_imprinting0.66421325
142MP0005408_hypopigmentation0.65810855
143MP0002752_abnormal_somatic_nervous0.64612618
144MP0005220_abnormal_exocrine_pancreas0.64067329
145MP0005395_other_phenotype0.63378808
146MP0005195_abnormal_posterior_eye0.63264553

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.84336244
2Chromsome breakage (HP:0040012)5.39707181
3Acute necrotizing encephalopathy (HP:0006965)4.63781302
4Mitochondrial inheritance (HP:0001427)4.20977795
5Acute encephalopathy (HP:0006846)4.19439509
6Increased hepatocellular lipid droplets (HP:0006565)4.17819836
7Abnormality of the renal collecting system (HP:0004742)4.03394146
8Abnormal mitochondria in muscle tissue (HP:0008316)3.97497461
9Progressive macrocephaly (HP:0004481)3.95906353
10Duplicated collecting system (HP:0000081)3.93283044
11Increased CSF lactate (HP:0002490)3.83839382
12Renal Fanconi syndrome (HP:0001994)3.77987302
13Lipid accumulation in hepatocytes (HP:0006561)3.77791467
14Hepatocellular necrosis (HP:0001404)3.57123023
15Hepatic necrosis (HP:0002605)3.36086292
16Parakeratosis (HP:0001036)3.17309838
17Cerebral edema (HP:0002181)3.15468251
18Reticulocytopenia (HP:0001896)3.10907415
19Abnormality of the preputium (HP:0100587)3.10280121
20True hermaphroditism (HP:0010459)3.00310599
21Hyperglycinemia (HP:0002154)2.90818305
22Abnormal number of erythroid precursors (HP:0012131)2.89538013
23Septo-optic dysplasia (HP:0100842)2.86280430
24Congenital primary aphakia (HP:0007707)2.84199953
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.80310608
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78011240
27Intestinal atresia (HP:0011100)2.77970468
28Gait imbalance (HP:0002141)2.77320687
29Clubbing of toes (HP:0100760)2.76124773
30Abnormality of the labia minora (HP:0012880)2.75327320
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.75082696
32Absent/shortened dynein arms (HP:0200106)2.75082696
33Pancreatic fibrosis (HP:0100732)2.74351180
34Meckel diverticulum (HP:0002245)2.72947846
35Abnormality of glycolysis (HP:0004366)2.69287299
36Abnormality of cells of the erythroid lineage (HP:0012130)2.67902910
37Abnormality of the ileum (HP:0001549)2.67711057
38Increased serum lactate (HP:0002151)2.67468148
39Increased serum pyruvate (HP:0003542)2.66960584
40Exertional dyspnea (HP:0002875)2.66498013
41Colon cancer (HP:0003003)2.65878621
42Methylmalonic acidemia (HP:0002912)2.65712513
43Hypothermia (HP:0002045)2.64587068
44Type I transferrin isoform profile (HP:0003642)2.64338780
45Lactic acidosis (HP:0003128)2.64280906
46Abnormality of renal resorption (HP:0011038)2.61204968
47Abnormality of DNA repair (HP:0003254)2.60474147
48Nephrogenic diabetes insipidus (HP:0009806)2.60444867
49Increased intramyocellular lipid droplets (HP:0012240)2.55775974
50Ectopic kidney (HP:0000086)2.55088123
51Abnormal ciliary motility (HP:0012262)2.52000866
52Methylmalonic aciduria (HP:0012120)2.51028484
53Type 2 muscle fiber atrophy (HP:0003554)2.48993208
54Microvesicular hepatic steatosis (HP:0001414)2.48274125
55Abnormal respiratory epithelium morphology (HP:0012253)2.47289447
56Abnormal respiratory motile cilium morphology (HP:0005938)2.47289447
57Prostate neoplasm (HP:0100787)2.45673884
58Abnormality of chromosome stability (HP:0003220)2.45060839
59Duplication of thumb phalanx (HP:0009942)2.39299115
60Respiratory failure (HP:0002878)2.37745087
61Hyperinsulinemic hypoglycemia (HP:0000825)2.34431799
62Birth length less than 3rd percentile (HP:0003561)2.34026390
63Exercise intolerance (HP:0003546)2.33838573
64Optic disc pallor (HP:0000543)2.30120066
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29926944
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29926944
67Abnormality of urine glucose concentration (HP:0011016)2.29847084
68Glycosuria (HP:0003076)2.29847084
69Optic neuritis (HP:0100653)2.29104241
70Retrobulbar optic neuritis (HP:0100654)2.29104241
71Pancreatic cysts (HP:0001737)2.28854870
72Respiratory difficulties (HP:0002880)2.28428032
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27954924
74Abnormal protein N-linked glycosylation (HP:0012347)2.27954924
75Abnormal protein glycosylation (HP:0012346)2.27954924
76Abnormal glycosylation (HP:0012345)2.27954924
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27924207
783-Methylglutaconic aciduria (HP:0003535)2.26713895
79Abnormality of the anterior horn cell (HP:0006802)2.26573340
80Degeneration of anterior horn cells (HP:0002398)2.26573340
81Genital tract atresia (HP:0001827)2.25637423
82Optic nerve hypoplasia (HP:0000609)2.25392164
83Vaginal atresia (HP:0000148)2.23171385
84Large for gestational age (HP:0001520)2.23076437
85Macrocytic anemia (HP:0001972)2.18739464
86Occipital encephalocele (HP:0002085)2.15427148
87Aplasia/Hypoplasia of the fovea (HP:0008060)2.14098162
88Hypoplasia of the fovea (HP:0007750)2.14098162
89Bone marrow hypocellularity (HP:0005528)2.12838258
90Muscle fiber atrophy (HP:0100295)2.12668019
91Lethargy (HP:0001254)2.09038636
92Tubulointerstitial nephritis (HP:0001970)2.08957664
93Increased muscle lipid content (HP:0009058)2.05503303
94Preaxial hand polydactyly (HP:0001177)2.05002783
95Small intestinal stenosis (HP:0012848)2.04769597
96Duodenal stenosis (HP:0100867)2.04769597
97Hyperglycinuria (HP:0003108)2.04397170
98Cheilitis (HP:0100825)2.03850658
99Aplasia/hypoplasia of the uterus (HP:0008684)2.03789277
100Nephroblastoma (Wilms tumor) (HP:0002667)2.03604002
101Reduced antithrombin III activity (HP:0001976)2.02232304
102Sclerocornea (HP:0000647)2.01478171
103Abnormal respiratory motile cilium physiology (HP:0012261)2.01049284
104Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99989108
105Abnormality of serum amino acid levels (HP:0003112)1.99767284
106Triphalangeal thumb (HP:0001199)1.98320541
107Ketoacidosis (HP:0001993)1.98095527
108Abnormality of the prostate (HP:0008775)1.97507127
109Abnormality of dental color (HP:0011073)1.97179561
110Abnormality of the carotid arteries (HP:0005344)1.96812574
111Aplastic anemia (HP:0001915)1.96722174
112Chronic mucocutaneous candidiasis (HP:0002728)1.95670131
113Recurrent cutaneous fungal infections (HP:0011370)1.95670131
114Pancreatic islet-cell hyperplasia (HP:0004510)1.94243663
115Absent septum pellucidum (HP:0001331)1.93902977
116Congenital stationary night blindness (HP:0007642)1.93902137
117Abnormality of glycine metabolism (HP:0010895)1.93828834
118Abnormality of serine family amino acid metabolism (HP:0010894)1.93828834
119Abnormality of alanine metabolism (HP:0010916)1.93807841
120Hyperalaninemia (HP:0003348)1.93807841
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93807841
122Hypergonadotropic hypogonadism (HP:0000815)1.93543693
123Hypoglycemic seizures (HP:0002173)1.93097018
124Oligohydramnios (HP:0001562)1.92033655
125Congenital sensorineural hearing impairment (HP:0008527)1.91348627
126Cystic liver disease (HP:0006706)1.90882397
127Febrile seizures (HP:0002373)1.90623836
128Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89993521
129Embryonal renal neoplasm (HP:0011794)1.89403870
130Rhinitis (HP:0012384)1.88933875
131Hypoplastic pelvis (HP:0008839)1.88669902
132Abnormality of midbrain morphology (HP:0002418)1.88655192
133Molar tooth sign on MRI (HP:0002419)1.88655192
134Aplasia/Hypoplasia of the tongue (HP:0010295)1.88599761
135Osteomalacia (HP:0002749)1.88301408
136Abnormality of the columella (HP:0009929)1.88173896
137Hyperphosphaturia (HP:0003109)1.87464804
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.87226854
139Adrenal hypoplasia (HP:0000835)1.87116581
140Patchy hypopigmentation of hair (HP:0011365)1.86135176
141Thyroid-stimulating hormone excess (HP:0002925)1.85540439
142Neoplasm of the adrenal gland (HP:0100631)1.85213753
143Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84385399
144Anencephaly (HP:0002323)1.84363036
145Abnormality of methionine metabolism (HP:0010901)1.84157488
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83589648
147Male pseudohermaphroditism (HP:0000037)1.83297757
148Panhypogammaglobulinemia (HP:0003139)1.82931233
149Leukodystrophy (HP:0002415)1.82090947
150Median cleft lip (HP:0000161)1.81920047
151Gastrointestinal atresia (HP:0002589)1.81080952
152Poor coordination (HP:0002370)1.79767358
153Abnormality of the septum pellucidum (HP:0007375)1.79421273
154Optic nerve coloboma (HP:0000588)1.79322485
155Myelodysplasia (HP:0002863)1.78381385
156Postaxial foot polydactyly (HP:0001830)1.78122593
157White forelock (HP:0002211)1.77479606
158Nephronophthisis (HP:0000090)1.77246685
159Neoplasm of the adrenal cortex (HP:0100641)1.76882699
160Aganglionic megacolon (HP:0002251)1.75763716
161Renal agenesis (HP:0000104)1.75137811
162Absent thumb (HP:0009777)1.74848832
163Medial flaring of the eyebrow (HP:0010747)1.72691152
164Upper limb muscle weakness (HP:0003484)1.72313177
165Nasolacrimal duct obstruction (HP:0000579)1.72000443
166Absent eyebrow (HP:0002223)1.71597356
167Premature graying of hair (HP:0002216)1.69682777
168Horseshoe kidney (HP:0000085)1.69107118
169Abnormal delayed hypersensitivity skin test (HP:0002963)1.68624212
170Abnormality of the fovea (HP:0000493)1.67301072
171Pancytopenia (HP:0001876)1.66865227
172Short middle phalanx of the 5th finger (HP:0004220)1.66102473
173Abnormality of the renal medulla (HP:0100957)1.66065019
174Short tibia (HP:0005736)1.65474814
175Renal dysplasia (HP:0000110)1.65237793
176Lip pit (HP:0100267)1.65219123
177Renal cortical cysts (HP:0000803)1.65125359
178Aplasia cutis congenita (HP:0001057)1.64464419
179Abnormality of incisor morphology (HP:0011063)1.64056677
180Chronic hepatic failure (HP:0100626)1.63646018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.79876486
2VRK23.41576160
3SIK33.33686701
4CASK2.95903418
5TNIK2.92725614
6ZAK2.83266929
7MAP4K22.49522479
8MST42.40163816
9IRAK42.37626488
10TXK2.36233034
11MKNK22.29286979
12BCKDK2.26486779
13VRK12.20762762
14IRAK32.10670401
15SRPK12.08557125
16PRPF4B2.05785795
17NEK12.01841888
18BMPR1B2.00763608
19BLK1.91240319
20ADRBK21.90715218
21PDK21.89486501
22MKNK11.87241015
23WNK31.84113203
24TAF11.83670238
25CDK81.83120383
26EIF2AK21.78286298
27PLK41.75443850
28BMPR21.59789532
29YES11.56513140
30GRK11.51533803
31TEC1.49975284
32INSRR1.38754391
33CDK31.37232121
34FRK1.34928501
35IRAK11.32563406
36MAP3K141.30430580
37MAPK131.28387816
38NUAK11.25365642
39IRAK21.24347948
40MAP2K71.20490495
41PNCK1.19141449
42CDC71.18251087
43CLK11.15821456
44MUSK1.15507947
45EIF2AK31.11032161
46TLK11.10334936
47BRD41.08917748
48ATR1.08652080
49PBK1.08161386
50TGFBR11.06964500
51TAOK31.06082900
52TTK1.06032170
53CSNK1G21.05193812
54CSNK1G31.04374946
55MAP3K121.03027559
56BRSK21.01891547
57NEK61.00551284
58FGFR20.98993708
59EPHA40.97926938
60TRIM280.97164186
61BUB10.96054159
62CCNB10.95274683
63PLK30.95078168
64SIK20.93433540
65KIT0.91951362
66ACVR1B0.91131955
67CSNK1G10.90182364
68NLK0.89444087
69PASK0.86048218
70CDK70.84942134
71MAP3K40.83403929
72PLK20.83082064
73AKT30.81991433
74GRK70.81900050
75PAK30.79595850
76IKBKE0.78709548
77CHEK20.77428191
78ERBB30.75361736
79PRKD30.75010849
80MARK30.74847931
81PIM20.71147946
82IKBKB0.70947294
83PLK10.69174639
84RPS6KA40.69087615
85LYN0.67830347
86TNK20.67477238
87BTK0.66554517
88FLT30.64287706
89PKN10.63914054
90PRKCI0.62122935
91STK38L0.62110109
92EIF2AK10.61073353
93SGK20.60720585
94MAPKAPK50.60678224
95AURKA0.60294891
96TESK10.58374526
97DYRK20.58279536
98JAK30.58222229
99WEE10.58200034
100BRAF0.57828481
101RPS6KA50.57448088
102AURKB0.54474206
103PRKCG0.53570610
104DAPK30.53123772
105TAOK20.53107770
106MAPK150.52720295
107LIMK10.52386924
108CSNK2A20.49807722
109TIE10.48966755
110ATM0.48697524
111DYRK30.48465481
112STK30.45482459
113TSSK60.45341014
114STK240.45168626
115OXSR10.43212243
116PRKCE0.42889580
117TESK20.42280647
118STK40.42082041
119FES0.41480255
120CSNK2A10.39948402
121BCR0.38724544
122SYK0.38720683
123MINK10.38272093
124NME20.37268482
125MAP2K60.35256715
126DAPK10.35007393
127CSNK1A10.34419097
128NEK20.33714010
129EPHB20.33576198
130CHUK0.32488293
131UHMK10.31956001
132BRSK10.31458911
133MYLK0.29704682
134NME10.27675867
135PIM10.27547274
136CHEK10.27409584
137NTRK30.26889544
138LCK0.26734297
139RPS6KA60.26596503
140CDK190.26405129
141CSNK1A1L0.26090069

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.13180202
2DNA replication_Homo sapiens_hsa030303.04822128
3Fanconi anemia pathway_Homo sapiens_hsa034603.01491910
4Mismatch repair_Homo sapiens_hsa034302.67517989
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48102034
6Propanoate metabolism_Homo sapiens_hsa006402.44083282
7RNA polymerase_Homo sapiens_hsa030202.42404934
8Basal transcription factors_Homo sapiens_hsa030222.24496906
9Non-homologous end-joining_Homo sapiens_hsa034502.23200467
10Base excision repair_Homo sapiens_hsa034102.19815212
11Alzheimers disease_Homo sapiens_hsa050102.08175506
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07949701
13Ribosome_Homo sapiens_hsa030102.06337127
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98754941
15Nucleotide excision repair_Homo sapiens_hsa034201.95886518
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83702263
17Fatty acid elongation_Homo sapiens_hsa000621.81919490
18Spliceosome_Homo sapiens_hsa030401.80595433
19Pyrimidine metabolism_Homo sapiens_hsa002401.79748413
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72699959
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72467247
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69231930
23RNA degradation_Homo sapiens_hsa030181.67585780
24Protein export_Homo sapiens_hsa030601.67005316
25Phototransduction_Homo sapiens_hsa047441.64753821
26Primary immunodeficiency_Homo sapiens_hsa053401.58889586
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.57345041
28Proteasome_Homo sapiens_hsa030501.55346524
29Steroid biosynthesis_Homo sapiens_hsa001001.48067381
30Autoimmune thyroid disease_Homo sapiens_hsa053201.45666020
31Allograft rejection_Homo sapiens_hsa053301.45334056
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44593749
33Cell cycle_Homo sapiens_hsa041101.43815863
34Purine metabolism_Homo sapiens_hsa002301.42464402
35Peroxisome_Homo sapiens_hsa041461.38987834
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38977157
37Butanoate metabolism_Homo sapiens_hsa006501.38399215
38Graft-versus-host disease_Homo sapiens_hsa053321.34872132
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.28511167
40Pyruvate metabolism_Homo sapiens_hsa006201.27148402
41Glutathione metabolism_Homo sapiens_hsa004801.23525882
42Sphingolipid metabolism_Homo sapiens_hsa006001.22601350
43Cardiac muscle contraction_Homo sapiens_hsa042601.20951661
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20538340
45Hematopoietic cell lineage_Homo sapiens_hsa046401.20014717
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.18769687
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.18503537
48Arachidonic acid metabolism_Homo sapiens_hsa005901.17977720
49Sulfur metabolism_Homo sapiens_hsa009201.17303403
50One carbon pool by folate_Homo sapiens_hsa006701.13443769
51Asthma_Homo sapiens_hsa053101.10786568
52Folate biosynthesis_Homo sapiens_hsa007901.08429504
53Nicotine addiction_Homo sapiens_hsa050331.08331298
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05852760
55Herpes simplex infection_Homo sapiens_hsa051681.05727346
56Selenocompound metabolism_Homo sapiens_hsa004501.05542296
57Measles_Homo sapiens_hsa051621.04360799
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98693950
59p53 signaling pathway_Homo sapiens_hsa041150.98457375
60Collecting duct acid secretion_Homo sapiens_hsa049660.97207923
61Ether lipid metabolism_Homo sapiens_hsa005650.96987498
62Taste transduction_Homo sapiens_hsa047420.94413065
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92248001
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91257456
65Metabolic pathways_Homo sapiens_hsa011000.88383817
66Tryptophan metabolism_Homo sapiens_hsa003800.88216178
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.88067314
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87496619
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83341417
70* RNA transport_Homo sapiens_hsa030130.83226304
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82808907
72Carbon metabolism_Homo sapiens_hsa012000.81686649
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79938108
74beta-Alanine metabolism_Homo sapiens_hsa004100.78948566
75mRNA surveillance pathway_Homo sapiens_hsa030150.78842113
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77852809
77Other glycan degradation_Homo sapiens_hsa005110.73263431
78Serotonergic synapse_Homo sapiens_hsa047260.72923073
79Type I diabetes mellitus_Homo sapiens_hsa049400.71674553
80Sulfur relay system_Homo sapiens_hsa041220.70978243
81Morphine addiction_Homo sapiens_hsa050320.70676529
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70280296
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70061258
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69507916
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68697988
86Rheumatoid arthritis_Homo sapiens_hsa053230.68478991
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66130101
88Fatty acid degradation_Homo sapiens_hsa000710.64278126
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62286206
90Regulation of autophagy_Homo sapiens_hsa041400.61691528
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61612068
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60971725
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.60372600
94Oxidative phosphorylation_Homo sapiens_hsa001900.59330472
95Chemical carcinogenesis_Homo sapiens_hsa052040.59197419
96Linoleic acid metabolism_Homo sapiens_hsa005910.57840500
97Fatty acid metabolism_Homo sapiens_hsa012120.57385517
98Huntingtons disease_Homo sapiens_hsa050160.56943375
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.56828671
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54965774
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54752338
102Influenza A_Homo sapiens_hsa051640.53333052
103Epstein-Barr virus infection_Homo sapiens_hsa051690.52412135
104Leishmaniasis_Homo sapiens_hsa051400.52084237
105Vitamin B6 metabolism_Homo sapiens_hsa007500.50558383
106Malaria_Homo sapiens_hsa051440.50004006
107Circadian rhythm_Homo sapiens_hsa047100.49914831
108Arginine and proline metabolism_Homo sapiens_hsa003300.49307947
109Ovarian steroidogenesis_Homo sapiens_hsa049130.49146211
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48534365
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46436929
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46134379
113Biosynthesis of amino acids_Homo sapiens_hsa012300.44527432
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44328822
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.43098829
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41416084
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.41175931
118Systemic lupus erythematosus_Homo sapiens_hsa053220.40879372
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39970979
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39825255
121Antigen processing and presentation_Homo sapiens_hsa046120.39015713
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38827919
123Parkinsons disease_Homo sapiens_hsa050120.38827570
124Melanoma_Homo sapiens_hsa052180.38716298
125Olfactory transduction_Homo sapiens_hsa047400.38324407
126HTLV-I infection_Homo sapiens_hsa051660.37988913
127African trypanosomiasis_Homo sapiens_hsa051430.37344754
128Notch signaling pathway_Homo sapiens_hsa043300.37128664
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36021522
130Basal cell carcinoma_Homo sapiens_hsa052170.35756352
131Retinol metabolism_Homo sapiens_hsa008300.34906997
132Oocyte meiosis_Homo sapiens_hsa041140.34450570
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34419996
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34095977
135Legionellosis_Homo sapiens_hsa051340.33524942
136N-Glycan biosynthesis_Homo sapiens_hsa005100.33166602
137Tuberculosis_Homo sapiens_hsa051520.32182778
138Apoptosis_Homo sapiens_hsa042100.31387828
139Wnt signaling pathway_Homo sapiens_hsa043100.30412470
140Phagosome_Homo sapiens_hsa041450.29450567
141Calcium signaling pathway_Homo sapiens_hsa040200.29065079
142Hepatitis B_Homo sapiens_hsa051610.28959871
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28667155
144Chemokine signaling pathway_Homo sapiens_hsa040620.28337117
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.22677103
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.21818074
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19025381
148Tyrosine metabolism_Homo sapiens_hsa003500.17481247

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