GEN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.78023244
2DNA unwinding involved in DNA replication (GO:0006268)5.32767193
3mitotic chromosome condensation (GO:0007076)5.23769393
4kinetochore organization (GO:0051383)5.14215971
5protein localization to chromosome, centromeric region (GO:0071459)5.07016472
6mitotic metaphase plate congression (GO:0007080)5.03902072
7nuclear pore organization (GO:0006999)5.00845810
8nuclear pore complex assembly (GO:0051292)4.97308311
9mitotic sister chromatid segregation (GO:0000070)4.95745184
10sister chromatid segregation (GO:0000819)4.90636893
11DNA double-strand break processing (GO:0000729)4.71891541
12DNA strand elongation involved in DNA replication (GO:0006271)4.67488991
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.65706537
14attachment of spindle microtubules to kinetochore (GO:0008608)4.62390563
15DNA replication initiation (GO:0006270)4.50538769
16mitotic nuclear envelope disassembly (GO:0007077)4.48895424
17metaphase plate congression (GO:0051310)4.46764370
18replication fork processing (GO:0031297)4.46452333
19DNA strand elongation (GO:0022616)4.43193046
20regulation of spindle organization (GO:0090224)4.41914372
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.40457292
22CENP-A containing nucleosome assembly (GO:0034080)4.37863783
23chromatin remodeling at centromere (GO:0031055)4.33372197
24telomere maintenance via semi-conservative replication (GO:0032201)4.32868932
25kinetochore assembly (GO:0051382)4.32791650
26mitotic sister chromatid cohesion (GO:0007064)4.32573297
27DNA replication checkpoint (GO:0000076)4.32372131
28DNA replication-dependent nucleosome assembly (GO:0006335)4.27740242
29DNA replication-dependent nucleosome organization (GO:0034723)4.27740242
30negative regulation of DNA-dependent DNA replication (GO:2000104)4.25352904
31mitotic recombination (GO:0006312)4.21780467
32establishment of chromosome localization (GO:0051303)4.19409240
33synapsis (GO:0007129)4.19282282
34membrane disassembly (GO:0030397)4.17803943
35nuclear envelope disassembly (GO:0051081)4.17803943
36telomere maintenance via recombination (GO:0000722)4.11816891
37positive regulation of chromosome segregation (GO:0051984)4.11132047
38* regulation of centrosome duplication (GO:0010824)4.10535680
39maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.08150433
40DNA replication-independent nucleosome assembly (GO:0006336)4.06026149
41DNA replication-independent nucleosome organization (GO:0034724)4.06026149
42positive regulation of mitotic sister chromatid separation (GO:1901970)4.00634774
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.00634774
44positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.00634774
45meiotic chromosome segregation (GO:0045132)3.94121614
46regulation of mitotic spindle organization (GO:0060236)3.89743678
47DNA ligation (GO:0006266)3.86787708
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.81514593
49* recombinational repair (GO:0000725)3.81349096
50* double-strand break repair via homologous recombination (GO:0000724)3.80815881
51pore complex assembly (GO:0046931)3.80357756
52sister chromatid cohesion (GO:0007062)3.79392626
53centriole replication (GO:0007099)3.77033584
54protein localization to chromosome (GO:0034502)3.76555828
55DNA duplex unwinding (GO:0032508)3.75184513
56spindle checkpoint (GO:0031577)3.75123494
57DNA geometric change (GO:0032392)3.74896758
58regulation of chromosome segregation (GO:0051983)3.73890230
59histone exchange (GO:0043486)3.73585093
60non-recombinational repair (GO:0000726)3.69656678
61double-strand break repair via nonhomologous end joining (GO:0006303)3.69656678
62DNA synthesis involved in DNA repair (GO:0000731)3.67109622
63chromosome segregation (GO:0007059)3.64671646
64chromosome condensation (GO:0030261)3.62565809
65regulation of sister chromatid cohesion (GO:0007063)3.60823649
66regulation of mitotic metaphase/anaphase transition (GO:0030071)3.57256892
67resolution of meiotic recombination intermediates (GO:0000712)3.56699606
68telomere maintenance via telomere lengthening (GO:0010833)3.56258720
69folic acid-containing compound biosynthetic process (GO:0009396)3.55137262
70chromatin assembly or disassembly (GO:0006333)3.54712852
71spindle assembly checkpoint (GO:0071173)3.53292560
72negative regulation of chromosome segregation (GO:0051985)3.50731105
73IMP biosynthetic process (GO:0006188)3.50313811
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.50242322
75DNA topological change (GO:0006265)3.49352042
76nucleotide-excision repair, DNA gap filling (GO:0006297)3.48995964
77regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.48825728
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.46310302
79negative regulation of sister chromatid segregation (GO:0033046)3.46310302
80negative regulation of mitotic sister chromatid separation (GO:2000816)3.46310302
81negative regulation of mitotic sister chromatid segregation (GO:0033048)3.46310302
82protein K6-linked ubiquitination (GO:0085020)3.46076243
83histone-serine phosphorylation (GO:0035404)3.45054670
84microtubule depolymerization (GO:0007019)3.41653877
85mitotic spindle assembly checkpoint (GO:0007094)3.40880904
86mitotic spindle checkpoint (GO:0071174)3.40141208
87* regulation of centrosome cycle (GO:0046605)3.38732400
88DNA conformation change (GO:0071103)3.37433210
89regulation of sister chromatid segregation (GO:0033045)3.36610450
90regulation of mitotic sister chromatid separation (GO:0010965)3.36610450
91regulation of mitotic sister chromatid segregation (GO:0033047)3.36610450
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.35721343
93nucleobase biosynthetic process (GO:0046112)3.34996807
94regulation of DNA endoreduplication (GO:0032875)3.33886048
95* double-strand break repair (GO:0006302)3.31371939
96regulation of centriole replication (GO:0046599)3.30970713
97DNA packaging (GO:0006323)3.29495983
98nuclear envelope organization (GO:0006998)3.28508836
99regulation of histone H3-K9 methylation (GO:0051570)3.26801742
100somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.25662133
101somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.25662133
102isotype switching (GO:0045190)3.25662133
103centrosome organization (GO:0051297)3.25235972
104negative regulation of DNA repair (GO:0045738)3.25142753
105DNA catabolic process, exonucleolytic (GO:0000738)3.24789578
106somatic recombination of immunoglobulin gene segments (GO:0016447)3.24592250
107ATP-dependent chromatin remodeling (GO:0043044)3.22121315
108pre-miRNA processing (GO:0031054)3.13980642
109telomere maintenance (GO:0000723)3.10818564
110somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09906836
111somatic hypermutation of immunoglobulin genes (GO:0016446)3.09906836
112formation of translation preinitiation complex (GO:0001731)3.09904927
113telomere organization (GO:0032200)3.09084047
114IMP metabolic process (GO:0046040)3.07598080
115mitotic cell cycle (GO:0000278)3.04023663
116purine nucleobase biosynthetic process (GO:0009113)3.03994078
117negative regulation of histone methylation (GO:0031061)2.97555823
118heterochromatin organization (GO:0070828)2.97022901
119mitotic G2/M transition checkpoint (GO:0044818)2.95879427
120translesion synthesis (GO:0019985)2.95453664
121ribosome assembly (GO:0042255)2.94575347
122negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89774201
123chromatin assembly (GO:0031497)2.89122480
124postreplication repair (GO:0006301)2.87563478
125mitotic DNA integrity checkpoint (GO:0044774)2.86699162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.68465636
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.83554987
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.08261516
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.61505517
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15691395
6AR_21909140_ChIP-Seq_LNCAP_Human2.74261520
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.72894060
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57510389
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.49563897
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48049949
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38705036
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34579728
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22551164
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22286082
15EWS_26573619_Chip-Seq_HEK293_Human2.21848534
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.21741489
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19638515
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13521630
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02953394
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00363099
21XRN2_22483619_ChIP-Seq_HELA_Human2.00072513
22E2F7_22180533_ChIP-Seq_HELA_Human10.8851711
23FUS_26573619_Chip-Seq_HEK293_Human1.98510491
24ZNF274_21170338_ChIP-Seq_K562_Hela1.97026870
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92618623
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.91507863
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86855438
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.86091046
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.83467842
30MYC_22102868_ChIP-Seq_BL_Human1.83103900
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79844969
32GATA1_22025678_ChIP-Seq_K562_Human1.79413146
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76799459
34VDR_23849224_ChIP-Seq_CD4+_Human1.76372489
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72270747
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66304391
37FOXP3_21729870_ChIP-Seq_TREG_Human1.65300776
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65127049
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59852201
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59456747
41ELK1_19687146_ChIP-ChIP_HELA_Human1.59392009
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56167973
43VDR_22108803_ChIP-Seq_LS180_Human1.55785707
44CIITA_25753668_ChIP-Seq_RAJI_Human1.54481707
45DCP1A_22483619_ChIP-Seq_HELA_Human1.53430609
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52828638
47TTF2_22483619_ChIP-Seq_HELA_Human1.51287699
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50921702
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50828638
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50787543
51IGF1R_20145208_ChIP-Seq_DFB_Human1.47156667
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47122338
53KDM5A_27292631_Chip-Seq_BREAST_Human1.43941177
54* GABP_19822575_ChIP-Seq_HepG2_Human1.42306027
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40300528
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.39571737
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38108558
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.36810145
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36521213
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35077671
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33936763
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32786815
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30854613
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.29343511
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28462328
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26773334
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26481452
68* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26280351
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25741700
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19140287
71TAF15_26573619_Chip-Seq_HEK293_Human1.18493136
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16868169
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16768072
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14885739
75ER_23166858_ChIP-Seq_MCF-7_Human1.14711683
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13916212
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12675655
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12669012
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11422120
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10591224
81VDR_21846776_ChIP-Seq_THP-1_Human1.09875095
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08123937
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07872566
84TFEB_21752829_ChIP-Seq_HELA_Human1.05380237
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04980811
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03716797
87IRF1_19129219_ChIP-ChIP_H3396_Human1.02261241
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00630438
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00541118
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98804256
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97114699
92* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96460749
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96292946
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95329890
95P300_19829295_ChIP-Seq_ESCs_Human0.94938629
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94929337
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94592535
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94525518
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94147732
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.93669610
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93107107
102NFE2_27457419_Chip-Seq_LIVER_Mouse0.91803950
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.91674794
104STAT3_23295773_ChIP-Seq_U87_Human0.91496712
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89773186
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89115902
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88800558
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88498760
109SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87548891
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87267312
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86254459
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85707289
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84446320
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82776167
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82584743
116MYC_18940864_ChIP-ChIP_HL60_Human0.80863819
117CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80636805
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.80378907
119SPI1_23547873_ChIP-Seq_NB4_Human0.80205922
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80202701
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80115600
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79616828
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.78590208
124TCF4_23295773_ChIP-Seq_U87_Human0.78555467
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78147824
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77948573
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76641568
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76517189
129YY1_21170310_ChIP-Seq_MESCs_Mouse0.75866533
130PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75483555
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75413464
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75340906
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.74315757
134CBP_20019798_ChIP-Seq_JUKART_Human0.74315757
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.74059068
136P300_18555785_Chip-Seq_ESCs_Mouse0.72892198
137CHD1_26751641_Chip-Seq_LNCaP_Human0.72057762
138MYB_26560356_Chip-Seq_TH1_Human0.71280705
139SRF_21415370_ChIP-Seq_HL-1_Mouse0.69553537
140MYB_26560356_Chip-Seq_TH2_Human0.69520309
141UTX_26944678_Chip-Seq_JUKART_Human0.66555279
142MAF_26560356_Chip-Seq_TH1_Human0.65881886
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.65811318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.97460752
2MP0003693_abnormal_embryo_hatching4.93534322
3MP0003111_abnormal_nucleus_morphology4.57226214
4MP0003077_abnormal_cell_cycle4.01077182
5MP0004957_abnormal_blastocyst_morpholog3.99360859
6MP0008057_abnormal_DNA_replication3.98748422
7MP0008058_abnormal_DNA_repair2.89620106
8MP0008007_abnormal_cellular_replicative2.60581563
9MP0003123_paternal_imprinting2.48501436
10MP0002009_preneoplasia2.46199250
11MP0008932_abnormal_embryonic_tissue2.43770548
12MP0009697_abnormal_copulation2.43010999
13MP0010307_abnormal_tumor_latency2.41599214
14MP0001730_embryonic_growth_arrest2.39877741
15MP0010352_gastrointestinal_tract_polyps2.36984632
16MP0000350_abnormal_cell_proliferation2.29559035
17MP0002396_abnormal_hematopoietic_system2.28463055
18MP0000372_irregular_coat_pigmentation2.11897066
19MP0005076_abnormal_cell_differentiation2.10598597
20MP0006292_abnormal_olfactory_placode2.02784704
21MP0008877_abnormal_DNA_methylation1.99543741
22MP0001672_abnormal_embryogenesis/_devel1.87097598
23MP0005380_embryogenesis_phenotype1.87097598
24MP0001697_abnormal_embryo_size1.81369611
25MP0003121_genomic_imprinting1.75087288
26MP0003984_embryonic_growth_retardation1.71682884
27MP0004808_abnormal_hematopoietic_stem1.70509964
28MP0002088_abnormal_embryonic_growth/wei1.68492415
29MP0002085_abnormal_embryonic_tissue1.63928769
30MP0002084_abnormal_developmental_patter1.58810106
31MP0003705_abnormal_hypodermis_morpholog1.58508143
32MP0002080_prenatal_lethality1.58381259
33MP0002086_abnormal_extraembryonic_tissu1.57963934
34MP0004197_abnormal_fetal_growth/weight/1.57408264
35MP0000490_abnormal_crypts_of1.51339891
36MP0003136_yellow_coat_color1.49732723
37MP0000427_abnormal_hair_cycle1.45550425
38MP0009053_abnormal_anal_canal1.42755717
39MP0003567_abnormal_fetal_cardiomyocyte1.39930281
40MP0003786_premature_aging1.38155589
41MP0000313_abnormal_cell_death1.37408562
42MP0002019_abnormal_tumor_incidence1.36555632
43MP0010030_abnormal_orbit_morphology1.35264715
44MP0003890_abnormal_embryonic-extraembry1.34544711
45MP0005253_abnormal_eye_physiology1.28856473
46MP0001293_anophthalmia1.23806444
47MP0000569_abnormal_digit_pigmentation1.21002324
48MP0000703_abnormal_thymus_morphology1.20608623
49MP0000537_abnormal_urethra_morphology1.17636851
50MP0006072_abnormal_retinal_apoptosis1.16432991
51MP0002398_abnormal_bone_marrow1.12300591
52MP0005551_abnormal_eye_electrophysiolog1.12195443
53MP0003943_abnormal_hepatobiliary_system1.11411904
54MP0005397_hematopoietic_system_phenotyp1.11173747
55MP0001545_abnormal_hematopoietic_system1.11173747
56MP0002938_white_spotting1.09703689
57MP0005171_absent_coat_pigmentation1.08845365
58MP0002822_catalepsy1.07960171
59MP0003566_abnormal_cell_adhesion1.06632888
60MP0003763_abnormal_thymus_physiology1.03366955
61MP0002722_abnormal_immune_system1.02154079
62MP0003937_abnormal_limbs/digits/tail_de1.00186770
63MP0009333_abnormal_splenocyte_physiolog1.00120182
64MP0006054_spinal_hemorrhage0.99306745
65MP0002210_abnormal_sex_determination0.98773066
66MP0003315_abnormal_perineum_morphology0.98109884
67MP0000015_abnormal_ear_pigmentation0.97210573
68MP0004264_abnormal_extraembryonic_tissu0.96703682
69MP0002102_abnormal_ear_morphology0.96242797
70MP0009672_abnormal_birth_weight0.96239461
71MP0000689_abnormal_spleen_morphology0.96181557
72MP0005023_abnormal_wound_healing0.94759608
73MP0003698_abnormal_male_reproductive0.93855857
74MP0005391_vision/eye_phenotype0.93588826
75MP0010678_abnormal_skin_adnexa0.93472395
76MP0001915_intracranial_hemorrhage0.92578864
77MP0000733_abnormal_muscle_development0.92128732
78MP0002234_abnormal_pharynx_morphology0.91857730
79MP0003718_maternal_effect0.90292233
80MP0002751_abnormal_autonomic_nervous0.88055741
81MP0005408_hypopigmentation0.86845111
82MP0001145_abnormal_male_reproductive0.86698305
83MP0003941_abnormal_skin_development0.86494528
84MP0009703_decreased_birth_body0.85469650
85MP0005621_abnormal_cell_physiology0.84049158
86MP0009278_abnormal_bone_marrow0.83278661
87MP0002092_abnormal_eye_morphology0.82279921
88MP0000631_abnormal_neuroendocrine_gland0.82142246
89MP0005075_abnormal_melanosome_morpholog0.82045602
90MP0002429_abnormal_blood_cell0.81484361
91MP0005384_cellular_phenotype0.81386962
92MP0000428_abnormal_craniofacial_morphol0.78994880
93MP0005083_abnormal_biliary_tract0.78959800
94MP0003115_abnormal_respiratory_system0.78198177
95MP0003656_abnormal_erythrocyte_physiolo0.77522150
96MP0001929_abnormal_gametogenesis0.77275193
97MP0000858_altered_metastatic_potential0.77057777
98MP0002111_abnormal_tail_morphology0.76831555
99MP0002160_abnormal_reproductive_system0.75129135
100MP0005174_abnormal_tail_pigmentation0.74609509
101MP0001119_abnormal_female_reproductive0.73856466
102MP0000653_abnormal_sex_gland0.73335781
103MP0000371_diluted_coat_color0.70247248
104MP0003646_muscle_fatigue0.69354311
105MP0000716_abnormal_immune_system0.69299049
106MP0001661_extended_life_span0.69280551
107MP0000432_abnormal_head_morphology0.69272761
108MP0003699_abnormal_female_reproductive0.68920441
109MP0000647_abnormal_sebaceous_gland0.68767917
110MP0005395_other_phenotype0.68700687
111MP0003119_abnormal_digestive_system0.68680407
112MP0002697_abnormal_eye_size0.68544255
113MP0002925_abnormal_cardiovascular_devel0.68524317
114MP0006035_abnormal_mitochondrial_morpho0.67728042
115MP0001324_abnormal_eye_pigmentation0.67493243
116MP0001286_abnormal_eye_development0.67029603
117MP0002166_altered_tumor_susceptibility0.66427857
118MP0004043_abnormal_pH_regulation0.65980771
119MP0002233_abnormal_nose_morphology0.65857614
120MP0003221_abnormal_cardiomyocyte_apopto0.63400078
121MP0003935_abnormal_craniofacial_develop0.62812893
122MP0003806_abnormal_nucleotide_metabolis0.62793670
123MP0001800_abnormal_humoral_immune0.61653471
124MP0000477_abnormal_intestine_morphology0.61564869
125MP0003195_calcinosis0.61428090
126MP0005195_abnormal_posterior_eye0.60909498
127MP0005389_reproductive_system_phenotype0.60748680
128MP0008995_early_reproductive_senescence0.60737074
129MP0005310_abnormal_salivary_gland0.59537908
130MP0002932_abnormal_joint_morphology0.58534756
131MP0003448_altered_tumor_morphology0.58060066
132MP0000383_abnormal_hair_follicle0.58031799
133MP0008961_abnormal_basal_metabolism0.56524236
134MP0003787_abnormal_imprinting0.56386214
135MP0005220_abnormal_exocrine_pancreas0.55938438
136MP0001243_abnormal_dermal_layer0.55606566
137MP0010234_abnormal_vibrissa_follicle0.55404954
138MP0000266_abnormal_heart_morphology0.54083737
139MP0002006_tumorigenesis0.53906019
140MP0008770_decreased_survivor_rate0.52726189
141MP0001849_ear_inflammation0.52463624
142MP0002095_abnormal_skin_pigmentation0.52308225
143MP0000358_abnormal_cell_content/0.50998428

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.74993544
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.47455452
3Birth length less than 3rd percentile (HP:0003561)3.98704446
4Abnormality of chromosome stability (HP:0003220)3.72899052
5Posterior subcapsular cataract (HP:0007787)3.62214918
6Selective tooth agenesis (HP:0001592)3.43965839
7Central scotoma (HP:0000603)3.39169649
8Volvulus (HP:0002580)3.30731049
9Meckel diverticulum (HP:0002245)3.28488883
10Ectopic kidney (HP:0000086)3.15315343
11Medulloblastoma (HP:0002885)3.12805194
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.12283149
13Abnormality of the ileum (HP:0001549)3.12187895
14Abnormality of the preputium (HP:0100587)3.06951924
15Breast hypoplasia (HP:0003187)3.06744903
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.02053619
17Short 4th metacarpal (HP:0010044)3.02053619
18Increased nuchal translucency (HP:0010880)2.97285585
19Patellar aplasia (HP:0006443)2.93034988
20Duodenal stenosis (HP:0100867)2.92449386
21Small intestinal stenosis (HP:0012848)2.92449386
22Deviation of the thumb (HP:0009603)2.90343491
23Reticulocytopenia (HP:0001896)2.88657869
24Proximal placement of thumb (HP:0009623)2.88211676
25Scotoma (HP:0000575)2.87819478
26Intestinal atresia (HP:0011100)2.87275929
27Impulsivity (HP:0100710)2.81311295
28Myelodysplasia (HP:0002863)2.76829403
29Ependymoma (HP:0002888)2.76262651
30Colon cancer (HP:0003003)2.73019585
31Aplasia/Hypoplasia of the patella (HP:0006498)2.69193292
32Abnormal number of incisors (HP:0011064)2.68176863
33Abnormal lung lobation (HP:0002101)2.57472850
34Rhabdomyosarcoma (HP:0002859)2.56882890
35Prominent nose (HP:0000448)2.55826792
36Abnormality of the labia minora (HP:0012880)2.53863580
37Agnosia (HP:0010524)2.51500286
38High pitched voice (HP:0001620)2.47962875
39Absent radius (HP:0003974)2.47653336
40Abnormality of the duodenum (HP:0002246)2.42898875
41Sloping forehead (HP:0000340)2.40930938
42Depressed nasal tip (HP:0000437)2.39918018
43Facial hemangioma (HP:0000329)2.37350021
44Hypoplasia of the pons (HP:0012110)2.37194005
45Oral leukoplakia (HP:0002745)2.35946129
46Cafe-au-lait spot (HP:0000957)2.31559236
47Cerebellar dysplasia (HP:0007033)2.31403382
48Aplasia involving forearm bones (HP:0009822)2.30334264
49Absent forearm bone (HP:0003953)2.30334264
50Chronic hepatic failure (HP:0100626)2.27840698
51Nephroblastoma (Wilms tumor) (HP:0002667)2.26398686
52Atresia of the external auditory canal (HP:0000413)2.26265121
53Abnormality of the pons (HP:0007361)2.25545352
54Abnormality of the carotid arteries (HP:0005344)2.25367952
5511 pairs of ribs (HP:0000878)2.25040499
56Abnormality of the fingertips (HP:0001211)2.24415217
57Basal cell carcinoma (HP:0002671)2.23054477
58Abnormality of the anterior horn cell (HP:0006802)2.21362867
59Degeneration of anterior horn cells (HP:0002398)2.21362867
60Bone marrow hypocellularity (HP:0005528)2.19503424
61Aplasia/Hypoplasia of the sternum (HP:0006714)2.15374412
62Embryonal renal neoplasm (HP:0011794)2.14370543
63Long eyelashes (HP:0000527)2.13564165
64Carpal bone hypoplasia (HP:0001498)2.12334712
65Squamous cell carcinoma (HP:0002860)2.09752694
66Absent thumb (HP:0009777)2.09023088
67Short thumb (HP:0009778)2.08134419
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07004287
69Abnormality of alanine metabolism (HP:0010916)2.07004287
70Hyperalaninemia (HP:0003348)2.07004287
71Astigmatism (HP:0000483)2.06001370
72Neoplasm of the pancreas (HP:0002894)2.05453872
73Tracheoesophageal fistula (HP:0002575)2.04701409
74Pancreatic cysts (HP:0001737)2.02330332
75Abnormality of DNA repair (HP:0003254)2.01296908
76Abnormality of the 4th metacarpal (HP:0010012)2.00601099
77Oligodactyly (hands) (HP:0001180)2.00218921
78Premature graying of hair (HP:0002216)1.98507384
79Neoplasm of the adrenal cortex (HP:0100641)1.97856013
80Duplicated collecting system (HP:0000081)1.97747994
81Clubbing of toes (HP:0100760)1.97291580
82Astrocytoma (HP:0009592)1.95945899
83Abnormality of the astrocytes (HP:0100707)1.95945899
84Deep philtrum (HP:0002002)1.93170316
85Skull defect (HP:0001362)1.92527875
86Subcapsular cataract (HP:0000523)1.92231168
87Poikiloderma (HP:0001029)1.92101099
88Bony spicule pigmentary retinopathy (HP:0007737)1.91857970
89Neoplasm of the colon (HP:0100273)1.91077942
90Rough bone trabeculation (HP:0100670)1.90007561
91Neoplasm of striated muscle (HP:0009728)1.89521365
92Short middle phalanx of the 5th finger (HP:0004220)1.88506132
93Attenuation of retinal blood vessels (HP:0007843)1.87679850
94Glioma (HP:0009733)1.86705774
95Cortical dysplasia (HP:0002539)1.86171639
96Lymphoma (HP:0002665)1.83744985
97B lymphocytopenia (HP:0010976)1.83361654
98Microtia (HP:0008551)1.82900249
99Missing ribs (HP:0000921)1.82701156
100Triphalangeal thumb (HP:0001199)1.82697120
101Biliary tract neoplasm (HP:0100574)1.82651339
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81785308
103Acute lymphatic leukemia (HP:0006721)1.81042219
104Cellular immunodeficiency (HP:0005374)1.81019342
105Chorioretinal atrophy (HP:0000533)1.80704427
106Embryonal neoplasm (HP:0002898)1.80461662
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78701131
108Horseshoe kidney (HP:0000085)1.78326774
109Supernumerary spleens (HP:0009799)1.78312913
110Acute myeloid leukemia (HP:0004808)1.78189015
111Abnormality of B cell number (HP:0010975)1.77751887
112Aplastic anemia (HP:0001915)1.76207226
113Type II lissencephaly (HP:0007260)1.75724655
114Oligohydramnios (HP:0001562)1.75247209
115Septo-optic dysplasia (HP:0100842)1.75044486
116Neoplasm of the oral cavity (HP:0100649)1.74972362
117Abnormality of chromosome segregation (HP:0002916)1.74773167
118Abnormality of the renal collecting system (HP:0004742)1.73834844
119Sandal gap (HP:0001852)1.73716348
120Abnormality of the calcaneus (HP:0008364)1.73712175
121Arteriovenous malformation (HP:0100026)1.73577127
122Cutaneous melanoma (HP:0012056)1.73551354
123Small hand (HP:0200055)1.72092886
124Esophageal atresia (HP:0002032)1.71948686
125Gastrointestinal carcinoma (HP:0002672)1.71321666
126Malignant gastrointestinal tract tumors (HP:0006749)1.71321666
127Abnormality of abdominal situs (HP:0011620)1.71195895
128Abdominal situs inversus (HP:0003363)1.71195895
129IgA deficiency (HP:0002720)1.70825949
130Choanal atresia (HP:0000453)1.70760112
131Ovarian neoplasm (HP:0100615)1.70372382
132Dandy-Walker malformation (HP:0001305)1.70357722
133Slender long bone (HP:0003100)1.69890338
134Constricted visual fields (HP:0001133)1.69291322
135Oligodactyly (HP:0012165)1.68621602
136Pendular nystagmus (HP:0012043)1.68565360
137Microretrognathia (HP:0000308)1.68384886
138Congenital stationary night blindness (HP:0007642)1.67785032
139Fair hair (HP:0002286)1.67685860
140Cutis marmorata (HP:0000965)1.67386895
141Abnormality of reticulocytes (HP:0004312)1.65735453
142Abnormality of the renal cortex (HP:0011035)1.65461734
143Nephronophthisis (HP:0000090)1.64457188
144Gastrointestinal atresia (HP:0002589)1.60184321
145Neoplasm of the small intestine (HP:0100833)1.59581435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.42326826
2BUB14.06891545
3WEE13.51075361
4NEK23.38465633
5FRK3.26516275
6CDK122.76280915
7TTK2.70298257
8EIF2AK12.57822223
9BRSK22.53829487
10NEK12.47452466
11PLK42.24237141
12SRPK12.21810539
13PLK12.17304946
14BRSK12.09821746
15AURKB2.05494915
16STK102.05329373
17BMPR1B1.91288969
18ATR1.84538807
19PLK31.82341896
20STK41.71989781
21CDK41.70824870
22CHEK21.65975235
23EEF2K1.62098452
24TAF11.61844432
25MKNK11.59640717
26ACVR1B1.58898448
27TLK11.56963925
28MAP3K81.56648905
29TSSK61.54349706
30MELK1.52092590
31PASK1.49957824
32STK391.49144305
33MAP3K101.45807488
34CHEK11.43714424
35RPS6KA41.41432119
36CDK71.39548655
37VRK11.37028938
38TESK21.36137958
39CDK61.35350005
40CCNB11.28289186
41STK31.27313440
42AURKA1.25250796
43RPS6KB21.23975574
44ZAK1.21572643
45SCYL21.11198474
46ATM1.10750437
47BRD41.10172100
48MKNK21.03393314
49TGFBR11.00289832
50PIM10.97400695
51MST40.96254074
52CLK10.96253514
53CDK20.95716295
54DYRK30.91780616
55MAP4K10.91449406
56NME20.91401540
57EIF2AK30.89552572
58PKN20.89301566
59WNK40.86893137
60TRIM280.86416471
61PAK40.82765588
62TEC0.81026772
63ERBB30.80954207
64CDK10.80926830
65ALK0.80395420
66OXSR10.79567029
67LATS10.74529800
68PBK0.69714904
69TTN0.65902192
70LRRK20.65897594
71PLK20.63378174
72MTOR0.62511452
73YES10.62001341
74TESK10.57366337
75WNK30.55775561
76CDK30.55740401
77MAP3K40.54391021
78EIF2AK20.53608693
79IRAK10.50913717
80BCR0.50798899
81EPHA20.50621987
82MAP4K20.49963800
83CDK90.49413326
84CSNK2A20.49088033
85CSNK2A10.49057223
86CDK80.49020384
87FGFR10.48871741
88MARK30.48090689
89ADRBK20.46811900
90AKT30.46659455
91PAK10.46280180
92RPS6KA50.45834256
93GRK10.44089934
94STK38L0.43468623
95BMPR20.43026010
96PRKDC0.41909616
97CSNK1D0.41290983
98MAPK130.40506684
99CAMK1G0.40425454
100CSNK1G10.39566273
101NEK90.39545574
102IRAK20.39450576
103TNIK0.37649395
104BLK0.36090926
105MAPK140.35252181
106INSRR0.34890865
107MAP3K140.34141000
108STK240.34014826
109MST1R0.32079830
110GRK60.31933711
111FLT30.31055432
112AKT20.30321320
113PDK20.30194962
114PRKCI0.29732771
115MAP2K30.29627415
116PAK20.28283144
117CSNK1E0.27480873
118RPS6KB10.26992848
119AKT10.25756051
120MAPKAPK20.24549735
121ZAP700.24506198
122MAPK110.23896593
123KDR0.22718007
124CHUK0.22395022
125JAK30.21391005
126PNCK0.21332626
127MAPK10.21229047
128GSK3B0.20458702
129NUAK10.20140798
130LATS20.19712912
131TRIB30.19661121
132TRPM70.19081929
133CDK150.18955775

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.14502087
2Mismatch repair_Homo sapiens_hsa034304.34772633
3Cell cycle_Homo sapiens_hsa041103.49341727
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25960428
5Homologous recombination_Homo sapiens_hsa034403.16160604
6RNA transport_Homo sapiens_hsa030133.08330836
7Base excision repair_Homo sapiens_hsa034103.08136402
8Spliceosome_Homo sapiens_hsa030403.06011939
9One carbon pool by folate_Homo sapiens_hsa006702.84938106
10Nucleotide excision repair_Homo sapiens_hsa034202.75064367
11Fanconi anemia pathway_Homo sapiens_hsa034602.61820984
12Non-homologous end-joining_Homo sapiens_hsa034502.54245677
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18092730
14Systemic lupus erythematosus_Homo sapiens_hsa053222.11760097
15RNA polymerase_Homo sapiens_hsa030202.04724249
16mRNA surveillance pathway_Homo sapiens_hsa030151.94401859
17Pyrimidine metabolism_Homo sapiens_hsa002401.94028466
18Proteasome_Homo sapiens_hsa030501.93956950
19p53 signaling pathway_Homo sapiens_hsa041151.91978193
20RNA degradation_Homo sapiens_hsa030181.91852551
21Ribosome_Homo sapiens_hsa030101.76198167
22Basal transcription factors_Homo sapiens_hsa030221.52176521
23Viral carcinogenesis_Homo sapiens_hsa052031.44639842
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31266486
25Oocyte meiosis_Homo sapiens_hsa041141.30040314
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24446207
27Epstein-Barr virus infection_Homo sapiens_hsa051691.22589950
28MicroRNAs in cancer_Homo sapiens_hsa052061.16204313
29Herpes simplex infection_Homo sapiens_hsa051681.13334382
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11344184
31HTLV-I infection_Homo sapiens_hsa051661.07980845
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05564530
33Small cell lung cancer_Homo sapiens_hsa052221.02776098
34Antigen processing and presentation_Homo sapiens_hsa046121.02075744
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99309032
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96672506
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95908577
38Propanoate metabolism_Homo sapiens_hsa006400.88992879
39Purine metabolism_Homo sapiens_hsa002300.87021820
40Alcoholism_Homo sapiens_hsa050340.85417997
41Protein export_Homo sapiens_hsa030600.84588893
42Steroid biosynthesis_Homo sapiens_hsa001000.81758341
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78283078
44Selenocompound metabolism_Homo sapiens_hsa004500.76539395
45Primary immunodeficiency_Homo sapiens_hsa053400.74284743
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74214608
47Chronic myeloid leukemia_Homo sapiens_hsa052200.71982328
48Phototransduction_Homo sapiens_hsa047440.70852726
49TGF-beta signaling pathway_Homo sapiens_hsa043500.68883170
50Hepatitis B_Homo sapiens_hsa051610.66517679
51Viral myocarditis_Homo sapiens_hsa054160.66442896
52Apoptosis_Homo sapiens_hsa042100.65788797
53Hippo signaling pathway_Homo sapiens_hsa043900.65247788
54Pentose phosphate pathway_Homo sapiens_hsa000300.64994154
55Colorectal cancer_Homo sapiens_hsa052100.64939820
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64221455
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.64192580
58Biosynthesis of amino acids_Homo sapiens_hsa012300.63685160
59Lysine degradation_Homo sapiens_hsa003100.63556569
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63322814
61Basal cell carcinoma_Homo sapiens_hsa052170.62212451
62Thyroid cancer_Homo sapiens_hsa052160.61771982
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60789257
64Adherens junction_Homo sapiens_hsa045200.60780900
65Butanoate metabolism_Homo sapiens_hsa006500.57512502
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56291665
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.56227553
68Nitrogen metabolism_Homo sapiens_hsa009100.55638659
69Measles_Homo sapiens_hsa051620.54745627
70Notch signaling pathway_Homo sapiens_hsa043300.51911664
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51613870
72Legionellosis_Homo sapiens_hsa051340.50252559
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.49097752
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48785300
75Pancreatic cancer_Homo sapiens_hsa052120.48256307
76Ether lipid metabolism_Homo sapiens_hsa005650.48142437
77Shigellosis_Homo sapiens_hsa051310.47599920
78Bladder cancer_Homo sapiens_hsa052190.44676152
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43705056
80Taste transduction_Homo sapiens_hsa047420.43651535
81mTOR signaling pathway_Homo sapiens_hsa041500.43497608
82Hematopoietic cell lineage_Homo sapiens_hsa046400.43456401
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42907766
84Prostate cancer_Homo sapiens_hsa052150.42538698
85Pathways in cancer_Homo sapiens_hsa052000.40035803
86Influenza A_Homo sapiens_hsa051640.39583514
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38698302
88Proteoglycans in cancer_Homo sapiens_hsa052050.38167813
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.36679673
90Vitamin B6 metabolism_Homo sapiens_hsa007500.36583384
91Non-small cell lung cancer_Homo sapiens_hsa052230.36372748
92Asthma_Homo sapiens_hsa053100.35741542
93Melanoma_Homo sapiens_hsa052180.35576226
94HIF-1 signaling pathway_Homo sapiens_hsa040660.34671766
95Pyruvate metabolism_Homo sapiens_hsa006200.33152472
96B cell receptor signaling pathway_Homo sapiens_hsa046620.31055506
97Sphingolipid metabolism_Homo sapiens_hsa006000.30970877
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30753996
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.30191582
100FoxO signaling pathway_Homo sapiens_hsa040680.30142633
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.29667111
102Hedgehog signaling pathway_Homo sapiens_hsa043400.29378647
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.28820169
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28586924
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.28313144
106Leishmaniasis_Homo sapiens_hsa051400.27803960
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27266795
108ABC transporters_Homo sapiens_hsa020100.26517883
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25961241
110Tryptophan metabolism_Homo sapiens_hsa003800.25700963
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23875754
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23854909
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23463614
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23394702
115T cell receptor signaling pathway_Homo sapiens_hsa046600.22634040
116N-Glycan biosynthesis_Homo sapiens_hsa005100.21933587
117Carbon metabolism_Homo sapiens_hsa012000.21859648
118Glutathione metabolism_Homo sapiens_hsa004800.21834825
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21261542
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20780474
121Allograft rejection_Homo sapiens_hsa053300.20425323
122Caffeine metabolism_Homo sapiens_hsa002320.20322475
123Wnt signaling pathway_Homo sapiens_hsa043100.20290821
124Toxoplasmosis_Homo sapiens_hsa051450.18948547
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18468857
126Folate biosynthesis_Homo sapiens_hsa007900.18332650
127Inositol phosphate metabolism_Homo sapiens_hsa005620.18247460
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18094770
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17329102
130Metabolic pathways_Homo sapiens_hsa011000.17284068
131Regulation of autophagy_Homo sapiens_hsa041400.16244858
132Fatty acid metabolism_Homo sapiens_hsa012120.15394239
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.15186943
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12127579
135Olfactory transduction_Homo sapiens_hsa047400.11841245
136Linoleic acid metabolism_Homo sapiens_hsa005910.11454211
137Autoimmune thyroid disease_Homo sapiens_hsa053200.10543722

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