GFER

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.12225215
2translational termination (GO:0006415)5.01349437
3ribosomal small subunit assembly (GO:0000028)4.86276405
4DNA deamination (GO:0045006)4.74399755
5ribosomal large subunit biogenesis (GO:0042273)4.68141178
6ribosomal small subunit biogenesis (GO:0042274)4.61674219
7GDP-mannose metabolic process (GO:0019673)4.60849884
8maturation of SSU-rRNA (GO:0030490)4.54577940
9regulation of mammary gland epithelial cell proliferation (GO:0033599)4.53362854
10translational elongation (GO:0006414)4.52810919
11folic acid-containing compound biosynthetic process (GO:0009396)4.45419188
12negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.33147228
13translational initiation (GO:0006413)4.19473900
14folic acid metabolic process (GO:0046655)4.16933428
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.16187711
16protein retention in ER lumen (GO:0006621)4.08854211
17protein targeting to ER (GO:0045047)4.04654102
18glycine metabolic process (GO:0006544)4.04013313
19cotranslational protein targeting to membrane (GO:0006613)4.03540824
20proline metabolic process (GO:0006560)4.03289599
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.96903624
22ribonucleoprotein complex biogenesis (GO:0022613)3.86755794
23cellular protein complex disassembly (GO:0043624)3.86624828
24protein localization to endoplasmic reticulum (GO:0070972)3.86475000
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.81775341
26viral life cycle (GO:0019058)3.81045680
27nucleobase biosynthetic process (GO:0046112)3.80198476
28peptidyl-arginine omega-N-methylation (GO:0035247)3.77886993
29purine nucleobase biosynthetic process (GO:0009113)3.74055145
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.73542144
31DNA strand elongation involved in DNA replication (GO:0006271)3.72556883
32apoptotic process involved in morphogenesis (GO:0060561)3.71354340
33formation of translation preinitiation complex (GO:0001731)3.65465714
34DNA replication initiation (GO:0006270)3.63511487
35regulation of early endosome to late endosome transport (GO:2000641)3.60340088
36regulation of translational fidelity (GO:0006450)3.57784644
37nucleobase-containing small molecule interconversion (GO:0015949)3.56519430
38pteridine-containing compound biosynthetic process (GO:0042559)3.55700804
39serine family amino acid biosynthetic process (GO:0009070)3.55553958
40DNA strand elongation (GO:0022616)3.50261177
41NADH metabolic process (GO:0006734)3.46754021
42protein complex disassembly (GO:0043241)3.46149485
43Golgi transport vesicle coating (GO:0048200)3.45022396
44COPI coating of Golgi vesicle (GO:0048205)3.45022396
45positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.44529542
46DNA replication-dependent nucleosome assembly (GO:0006335)3.43894506
47DNA replication-dependent nucleosome organization (GO:0034723)3.43894506
48heterochromatin organization (GO:0070828)3.43385085
49telomere maintenance via semi-conservative replication (GO:0032201)3.38060887
50ribosome biogenesis (GO:0042254)3.37262465
51DNA unwinding involved in DNA replication (GO:0006268)3.35162557
52mitotic metaphase plate congression (GO:0007080)3.33112318
53tetrahydrofolate metabolic process (GO:0046653)3.31143593
54negative regulation of cell size (GO:0045792)3.30643855
55protein complex localization (GO:0031503)3.29212426
56histone arginine methylation (GO:0034969)3.29079066
57protein localization to kinetochore (GO:0034501)3.28486706
58translation (GO:0006412)3.27410190
59macromolecular complex disassembly (GO:0032984)3.27108114
60glutamine family amino acid biosynthetic process (GO:0009084)3.21970556
61folic acid-containing compound metabolic process (GO:0006760)3.21664612
62serine family amino acid metabolic process (GO:0009069)3.21606948
63protein localization to chromosome, centromeric region (GO:0071459)3.19879609
64rRNA processing (GO:0006364)3.18862990
65retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.18487470
66nucleoside diphosphate biosynthetic process (GO:0009133)3.18196110
67DNA replication checkpoint (GO:0000076)3.17912315
68mitotic chromosome condensation (GO:0007076)3.15903330
69regulation of apoptotic process involved in morphogenesis (GO:1902337)3.14733134
70L-serine metabolic process (GO:0006563)3.13838525
71mitochondrial fusion (GO:0008053)3.12569727
72spliceosomal tri-snRNP complex assembly (GO:0000244)3.12383401
73rRNA metabolic process (GO:0016072)3.08950597
74protein maturation by protein folding (GO:0022417)3.08727120
75proteasome assembly (GO:0043248)3.06650142
76UV protection (GO:0009650)3.06145932
77spliceosomal snRNP assembly (GO:0000387)3.05919570
78serine family amino acid catabolic process (GO:0009071)3.05195640
79focal adhesion assembly (GO:0048041)3.04758080
80cell-substrate adherens junction assembly (GO:0007045)3.04758080
81regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.02447339
82cellular component biogenesis (GO:0044085)3.01810686
83IMP biosynthetic process (GO:0006188)2.99801534
84mitotic nuclear envelope disassembly (GO:0007077)2.98832977
85adherens junction assembly (GO:0034333)2.98616598
86pteridine-containing compound metabolic process (GO:0042558)2.95107300
87pseudouridine synthesis (GO:0001522)2.94074438
88nuclear-transcribed mRNA catabolic process (GO:0000956)2.93646403
89ribosome assembly (GO:0042255)2.93562486
90rRNA transcription (GO:0009303)2.92550417
91maternal placenta development (GO:0001893)2.92543905
92L-phenylalanine metabolic process (GO:0006558)2.90325411
93erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.90325411
94peptidyl-arginine N-methylation (GO:0035246)2.89076882
95peptidyl-arginine methylation (GO:0018216)2.89076882
96glucose 6-phosphate metabolic process (GO:0051156)2.88412627
97mannose metabolic process (GO:0006013)2.87855635
98regulation of cholesterol homeostasis (GO:2000188)2.87583437
99pentose metabolic process (GO:0019321)2.86669347
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85830215
101chromatin remodeling at centromere (GO:0031055)2.85174003
102planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84800345
103positive regulation of Cdc42 GTPase activity (GO:0043089)2.84080836
104telomere maintenance via recombination (GO:0000722)2.83959369
105cysteine metabolic process (GO:0006534)2.82300247
106nucleoside salvage (GO:0043174)2.81982329
107urea cycle (GO:0000050)2.81122139
108protein insertion into membrane (GO:0051205)2.80806492
109one-carbon metabolic process (GO:0006730)2.78811283
110proline biosynthetic process (GO:0006561)2.77455577
111mRNA catabolic process (GO:0006402)2.76573840
1123-UTR-mediated mRNA stabilization (GO:0070935)2.75627221
113positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.75435996
114nuclear envelope disassembly (GO:0051081)2.72711372
115membrane disassembly (GO:0030397)2.72711372
116RNA catabolic process (GO:0006401)2.72600133
117activation of MAPKKK activity (GO:0000185)2.72170604
118pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.71353806
119pentose-phosphate shunt (GO:0006098)2.71224175
120chaperone-mediated protein complex assembly (GO:0051131)2.70116933
121CENP-A containing nucleosome assembly (GO:0034080)2.69963169
122IMP metabolic process (GO:0046040)2.69379383
123modulation by virus of host process (GO:0019054)2.68399132
124mitotic recombination (GO:0006312)2.68078494
125monosaccharide biosynthetic process (GO:0046364)2.68039543
126protein localization to endosome (GO:0036010)2.67615892
127modulation by symbiont of host cellular process (GO:0044068)2.67294209
128cellular protein complex localization (GO:0034629)2.66020248
129regulation of translational termination (GO:0006449)2.65890325
130protein targeting to membrane (GO:0006612)2.64946094
131telomere maintenance via telomere lengthening (GO:0010833)2.64509201
132metaphase plate congression (GO:0051310)2.62615989
133rRNA modification (GO:0000154)2.62453970
134maturation of 5.8S rRNA (GO:0000460)2.62067363
135sulfur amino acid catabolic process (GO:0000098)2.60159674
136glucose catabolic process (GO:0006007)2.59111646
137cell-cell junction maintenance (GO:0045217)2.58607489
138gluconeogenesis (GO:0006094)2.56909254
139spliceosomal complex assembly (GO:0000245)2.56802825
140RNA stabilization (GO:0043489)2.56008234
141mRNA stabilization (GO:0048255)2.56008234
142deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55195173
143sulfur amino acid biosynthetic process (GO:0000097)2.54324344
144glycosphingolipid catabolic process (GO:0046479)2.54090313
145nucleotide-excision repair, DNA gap filling (GO:0006297)2.53276713
146fructose metabolic process (GO:0006000)2.52535227
147hexose biosynthetic process (GO:0019319)2.51753183
148DNA replication-independent nucleosome assembly (GO:0006336)2.49308727
149DNA replication-independent nucleosome organization (GO:0034724)2.49308727
150anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49291171
151nucleosome disassembly (GO:0006337)2.49005499
152protein-DNA complex disassembly (GO:0032986)2.49005499
153mitotic nuclear envelope reassembly (GO:0007084)2.48831122
154nuclear envelope reassembly (GO:0031468)2.48831122
155negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.48481730
156regulation of glucose import in response to insulin stimulus (GO:2001273)2.48411651
157negative regulation of erythrocyte differentiation (GO:0045647)2.48034349
158nuclear pore organization (GO:0006999)2.47638797
159urea metabolic process (GO:0019627)2.47602236
160intracellular estrogen receptor signaling pathway (GO:0030520)2.47414625
161ncRNA 3-end processing (GO:0043628)2.47140109
162regulation of cholesterol biosynthetic process (GO:0045540)2.46054406
163histone exchange (GO:0043486)2.45854362
164regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.45102013
165amino acid salvage (GO:0043102)2.44888596
166L-methionine salvage (GO:0071267)2.44888596
167L-methionine biosynthetic process (GO:0071265)2.44888596
168regulation of chromatin binding (GO:0035561)2.44824747
169negative regulation of viral release from host cell (GO:1902187)2.44591147
170negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44550024
171adenine nucleotide transport (GO:0051503)2.43855064
172pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.43349213
173diacylglycerol metabolic process (GO:0046339)2.43319070
174negative regulation of translational initiation (GO:0045947)2.42781663
175regulation of spindle organization (GO:0090224)2.42707931
176erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.40629314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.08614431
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.26894560
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77626877
4MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99681283
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89474607
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.87833666
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.75243176
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71040621
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70464160
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.67163275
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66868247
12LXR_22292898_ChIP-Seq_THP-1_Human2.64755713
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60733293
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57544779
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.53693496
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52905152
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.49055349
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39731736
19XRN2_22483619_ChIP-Seq_HELA_Human2.28819234
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15447622
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13129008
22* RACK7_27058665_Chip-Seq_MCF-7_Human2.09490785
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.08331433
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05093943
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03714568
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02334582
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01838193
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97011123
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95857960
30DCP1A_22483619_ChIP-Seq_HELA_Human1.95611243
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.92986041
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91261824
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88919206
34VDR_23849224_ChIP-Seq_CD4+_Human1.84569725
35AR_21909140_ChIP-Seq_LNCAP_Human1.83384904
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.82891291
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.82215072
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77372567
39P68_20966046_ChIP-Seq_HELA_Human1.73723246
40GABP_19822575_ChIP-Seq_HepG2_Human1.73646499
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73275312
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72391358
43* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.72154094
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.72015436
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69361131
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69159381
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.68122581
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67619990
49FOXP3_21729870_ChIP-Seq_TREG_Human1.66899180
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64415688
51KDM2B_26808549_Chip-Seq_DND41_Human1.63665896
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63230624
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58910604
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58844592
55TTF2_22483619_ChIP-Seq_HELA_Human1.58559929
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56809816
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56097503
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.52253141
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50619733
60* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49889503
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48449887
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47021459
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46355551
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.46345721
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45834300
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.44684126
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44653736
68TCF7_22412390_ChIP-Seq_EML_Mouse1.44167845
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43877686
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43781725
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43044506
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38506326
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38046023
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.37345114
75SMC4_20622854_ChIP-Seq_HELA_Human1.37333775
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36156260
77KDM5A_27292631_Chip-Seq_BREAST_Human1.34934756
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.34284715
79MAF_26560356_Chip-Seq_TH2_Human1.33769896
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33265172
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32900449
82KDM2B_26808549_Chip-Seq_K562_Human1.32094931
83CREB1_26743006_Chip-Seq_LNCaP_Human1.31971359
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30473232
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.29805782
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28265541
87BCOR_27268052_Chip-Seq_Bcells_Human1.28152469
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26224743
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25410790
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.25143665
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24096922
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23508244
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23004092
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21076023
95BCL6_27268052_Chip-Seq_Bcells_Human1.20397480
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20321985
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20053756
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19648162
99MYC_22102868_ChIP-Seq_BL_Human1.19304464
100ATF3_27146783_Chip-Seq_COLON_Human1.19265198
101* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19168429
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18721156
103VDR_24763502_ChIP-Seq_THP-1_Human1.18646068
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15868551
105RARA_24833708_ChIP-Seq_LIVER_Mouse1.15761576
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15570107
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15231646
108* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13964483
109MAF_26560356_Chip-Seq_TH1_Human1.13665758
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13628328
111CTCF_21964334_Chip-Seq_Bcells_Human1.13564531
112* NCOR1_26117541_ChIP-Seq_K562_Human1.13254527
113TP53_22127205_ChIP-Seq_IMR90_Human1.12443371
114* CTCF_27219007_Chip-Seq_Bcells_Human1.12342737
115TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10651666
116CTCF_26484167_Chip-Seq_Bcells_Mouse1.10419829
117CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10393101
118PHF8_20622854_ChIP-Seq_HELA_Human1.10215847
119* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09350687
120* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08758760
121* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08228552
122ESR2_21235772_ChIP-Seq_MCF-7_Human1.07318459
123HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07160395
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06675508
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06608864
126KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06352064
127SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06189786
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06071909
129ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04988805
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04441165
131SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04032613
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03869673
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03762542
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03017160
135SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02958156
136SA1_27219007_Chip-Seq_Bcells_Human1.02801363
137* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02534711
138SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02236472
139CIITA_25753668_ChIP-Seq_RAJI_Human1.00652896
140* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99899357
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99502974
142CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99167516
143ELK1_19687146_ChIP-ChIP_HELA_Human0.99117128
144SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98344730
145TFEB_21752829_ChIP-Seq_HELA_Human0.97784185
146* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97691389
147MYC_18940864_ChIP-ChIP_HL60_Human0.96637694
148ZNF263_19887448_ChIP-Seq_K562_Human0.96200372
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94308967
150LXR_22158963_ChIP-Seq_LIVER_Mouse0.93348781
151NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92497942
152PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92290124
153HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91609677
154VDR_21846776_ChIP-Seq_THP-1_Human0.86654333
155ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85094403
156* FOXP1_21924763_ChIP-Seq_HESCs_Human0.84440074
157FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84155993
158* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83745202
159KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83012417
160KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83012417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.33071550
2MP0003693_abnormal_embryo_hatching4.11986931
3MP0002139_abnormal_hepatobiliary_system3.90779843
4MP0005360_urolithiasis3.80441440
5MP0004957_abnormal_blastocyst_morpholog3.51813542
6MP0005058_abnormal_lysosome_morphology3.46340582
7MP0003111_abnormal_nucleus_morphology3.24464246
8MP0000678_abnormal_parathyroid_gland3.00068882
9MP0005085_abnormal_gallbladder_physiolo2.98816412
10MP0010094_abnormal_chromosome_stability2.86707843
11MP0010234_abnormal_vibrissa_follicle2.81121589
12MP0003077_abnormal_cell_cycle2.78695108
13MP0005365_abnormal_bile_salt2.72717188
14MP0001849_ear_inflammation2.62924934
15MP0004185_abnormal_adipocyte_glucose2.37027340
16MP0004858_abnormal_nervous_system2.36732322
17MP0009840_abnormal_foam_cell2.31906759
18MP0002249_abnormal_larynx_morphology2.29497276
19MP0005409_darkened_coat_color2.18547996
20MP0010352_gastrointestinal_tract_polyps2.15020937
21MP0008058_abnormal_DNA_repair2.09290521
22MP0003718_maternal_effect2.07558578
23MP0008875_abnormal_xenobiotic_pharmacok2.06137277
24MP0003186_abnormal_redox_activity1.97487944
25MP0008057_abnormal_DNA_replication1.96985700
26MP0003705_abnormal_hypodermis_morpholog1.96250073
27MP0001730_embryonic_growth_arrest1.92727565
28MP0008932_abnormal_embryonic_tissue1.91592812
29MP0003453_abnormal_keratinocyte_physiol1.84594073
30MP0002877_abnormal_melanocyte_morpholog1.84329810
31MP0009379_abnormal_foot_pigmentation1.78305493
32MP0004233_abnormal_muscle_weight1.75271909
33MP0002796_impaired_skin_barrier1.74483558
34MP0002089_abnormal_postnatal_growth/wei1.72251155
35MP0004264_abnormal_extraembryonic_tissu1.70466605
36MP0005083_abnormal_biliary_tract1.69550086
37MP0008007_abnormal_cellular_replicative1.64426349
38MP0001348_abnormal_lacrimal_gland1.63902438
39MP0008260_abnormal_autophagy1.62881779
40MP0005332_abnormal_amino_acid1.60275741
41MP0003123_paternal_imprinting1.57968988
42MP0000350_abnormal_cell_proliferation1.53940577
43MP0006036_abnormal_mitochondrial_physio1.52662519
44MP0000490_abnormal_crypts_of1.52020696
45MP0005666_abnormal_adipose_tissue1.45857009
46MP0003656_abnormal_erythrocyte_physiolo1.41065539
47MP0010329_abnormal_lipoprotein_level1.39012513
48MP0003252_abnormal_bile_duct1.38294941
49MP0000747_muscle_weakness1.36943072
50MP0002132_abnormal_respiratory_system1.30950658
51MP0000609_abnormal_liver_physiology1.29950675
52MP0009278_abnormal_bone_marrow1.28678911
53MP0001697_abnormal_embryo_size1.27776147
54MP0005380_embryogenesis_phenotype1.27389446
55MP0001672_abnormal_embryogenesis/_devel1.27389446
56MP0010030_abnormal_orbit_morphology1.27012485
57MP0001764_abnormal_homeostasis1.26820948
58MP0003011_delayed_dark_adaptation1.26047972
59MP0005623_abnormal_meninges_morphology1.25444817
60MP0010307_abnormal_tumor_latency1.23781520
61MP0005410_abnormal_fertilization1.23479652
62MP0002080_prenatal_lethality1.20375182
63MP0002653_abnormal_ependyma_morphology1.19916285
64MP0001666_abnormal_nutrient_absorption1.19872583
65MP0009053_abnormal_anal_canal1.18579777
66MP0005319_abnormal_enzyme/_coenzyme1.18345587
67MP0005257_abnormal_intraocular_pressure1.14356935
68MP0004019_abnormal_vitamin_homeostasis1.14262883
69MP0003786_premature_aging1.13875312
70MP0003984_embryonic_growth_retardation1.12598903
71MP0001661_extended_life_span1.12017839
72MP0002088_abnormal_embryonic_growth/wei1.11629761
73MP0005375_adipose_tissue_phenotype1.11225392
74MP0002396_abnormal_hematopoietic_system1.10838690
75MP0002019_abnormal_tumor_incidence1.09789633
76MP0000598_abnormal_liver_morphology1.09560618
77MP0003303_peritoneal_inflammation1.09328231
78MP0001929_abnormal_gametogenesis1.08927545
79MP0001346_abnormal_lacrimal_gland1.08689858
80MP0000681_abnormal_thyroid_gland1.08576300
81MP0000003_abnormal_adipose_tissue1.08216387
82MP0000313_abnormal_cell_death1.07476645
83MP0000750_abnormal_muscle_regeneration1.07345389
84MP0006035_abnormal_mitochondrial_morpho1.06890296
85MP0002085_abnormal_embryonic_tissue1.06400737
86MP0002210_abnormal_sex_determination1.06327420
87MP0000733_abnormal_muscle_development1.04905051
88MP0002138_abnormal_hepatobiliary_system1.04705467
89MP0002086_abnormal_extraembryonic_tissu1.04233948
90MP0005266_abnormal_metabolism1.03104340
91MP0001145_abnormal_male_reproductive1.02794083
92MP0003172_abnormal_lysosome_physiology1.00864294
93MP0000358_abnormal_cell_content/0.97596814
94MP0003567_abnormal_fetal_cardiomyocyte0.96027733
95MP0001188_hyperpigmentation0.95733174
96MP0004197_abnormal_fetal_growth/weight/0.95197968
97MP0001873_stomach_inflammation0.95046180
98MP0003119_abnormal_digestive_system0.90333658
99MP0000759_abnormal_skeletal_muscle0.89586987
100MP0005330_cardiomyopathy0.89440495
101MP0009643_abnormal_urine_homeostasis0.89053262
102MP0000653_abnormal_sex_gland0.88822332
103MP0002084_abnormal_developmental_patter0.88801546
104MP0004133_heterotaxia0.88236118
105MP0002098_abnormal_vibrissa_morphology0.84338635
106MP0003329_amyloid_beta_deposits0.81893009
107MP0005397_hematopoietic_system_phenotyp0.81248258
108MP0001545_abnormal_hematopoietic_system0.81248258
109MP0004782_abnormal_surfactant_physiolog0.81128435
110MP0003566_abnormal_cell_adhesion0.80269878
111MP0009333_abnormal_splenocyte_physiolog0.80257769
112MP0005023_abnormal_wound_healing0.80150464
113MP0000858_altered_metastatic_potential0.79408702
114MP0000751_myopathy0.79383494
115MP0001293_anophthalmia0.78145770
116MP0001727_abnormal_embryo_implantation0.78030448
117MP0003195_calcinosis0.77968994
118MP0000477_abnormal_intestine_morphology0.77858235
119MP0002254_reproductive_system_inflammat0.76903586
120MP0009672_abnormal_birth_weight0.76474880
121MP0003890_abnormal_embryonic-extraembry0.76109844
122MP0005451_abnormal_body_composition0.75843688
123MP0003942_abnormal_urinary_system0.75582472
124MP0003315_abnormal_perineum_morphology0.75509049
125MP0001881_abnormal_mammary_gland0.74205789
126MP0005395_other_phenotype0.74084855
127MP0003879_abnormal_hair_cell0.74020644
128MP0005501_abnormal_skin_physiology0.73738085
129MP0010155_abnormal_intestine_physiology0.73543344
130MP0004087_abnormal_muscle_fiber0.72953510
131MP0004510_myositis0.71618630
132MP0010630_abnormal_cardiac_muscle0.71263699
133MP0009931_abnormal_skin_appearance0.70682099
134MP0005376_homeostasis/metabolism_phenot0.70582289
135MP0003191_abnormal_cellular_cholesterol0.70363701
136MP0004947_skin_inflammation0.70270920
137MP0002160_abnormal_reproductive_system0.69194295
138MP0000462_abnormal_digestive_system0.68896803
139MP0001216_abnormal_epidermal_layer0.67846762
140MP0005220_abnormal_exocrine_pancreas0.66323730
141MP0005076_abnormal_cell_differentiation0.65782309
142MP0005636_abnormal_mineral_homeostasis0.65656481
143MP0001915_intracranial_hemorrhage0.65582101
144MP0002092_abnormal_eye_morphology0.65074719
145MP0005621_abnormal_cell_physiology0.64867549
146MP0001119_abnormal_female_reproductive0.64638612
147MP0003221_abnormal_cardiomyocyte_apopto0.64469789
148MP0000537_abnormal_urethra_morphology0.64123466
149MP0003698_abnormal_male_reproductive0.64020136
150MP0002118_abnormal_lipid_homeostasis0.63815344
151MP0005670_abnormal_white_adipose0.63798456
152MP0009697_abnormal_copulation0.62092020
153MP0005389_reproductive_system_phenotype0.61856427
154MP0005584_abnormal_enzyme/coenzyme_acti0.61181106

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.70713708
2Reticulocytopenia (HP:0001896)4.67383151
3Abnormal number of erythroid precursors (HP:0012131)4.39180060
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.12382844
5Macrocytic anemia (HP:0001972)3.86920417
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.84870863
7Abnormality of pyrimidine metabolism (HP:0004353)3.79947448
8Hyperglycinemia (HP:0002154)3.64574916
9Intrahepatic cholestasis (HP:0001406)3.60927411
10Oral leukoplakia (HP:0002745)3.56657284
11Hypobetalipoproteinemia (HP:0003563)3.55411755
12Myopathic facies (HP:0002058)3.40441600
13Breast hypoplasia (HP:0003187)3.38523246
14Hyperacusis (HP:0010780)3.33555065
15Pallor (HP:0000980)3.31651195
16Hyperglycinuria (HP:0003108)3.29218882
17Birth length less than 3rd percentile (HP:0003561)3.18042249
18Hyperammonemia (HP:0001987)3.17869816
19Multiple enchondromatosis (HP:0005701)3.15703832
20Achilles tendon contracture (HP:0001771)3.12472413
21Ulnar bowing (HP:0003031)3.01915539
22Abnormality of glycine metabolism (HP:0010895)3.00452059
23Abnormality of serine family amino acid metabolism (HP:0010894)3.00452059
24Thin bony cortex (HP:0002753)2.95450422
25Abnormality of the Achilles tendon (HP:0005109)2.88024563
26Abnormality of serum amino acid levels (HP:0003112)2.87790315
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.83224438
28Xanthomatosis (HP:0000991)2.79973432
29Abnormal hemoglobin (HP:0011902)2.76571976
30Abnormality of reticulocytes (HP:0004312)2.73060232
31Trismus (HP:0000211)2.72393915
32Abnormality of methionine metabolism (HP:0010901)2.68364363
33Deep venous thrombosis (HP:0002625)2.67334821
34Colon cancer (HP:0003003)2.66309386
35Rough bone trabeculation (HP:0100670)2.62936310
36Hemorrhage of the eye (HP:0011885)2.62440424
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.60578611
38Premature ovarian failure (HP:0008209)2.59466523
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.57201466
40Lethargy (HP:0001254)2.56617795
41Hepatic necrosis (HP:0002605)2.53940627
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52749114
43Vertebral compression fractures (HP:0002953)2.52595679
44Hypolipoproteinemia (HP:0010981)2.52292236
45Microretrognathia (HP:0000308)2.49734097
46Increased serum lactate (HP:0002151)2.48841920
47Aplastic anemia (HP:0001915)2.48116406
48Cerebral edema (HP:0002181)2.47085830
49Impulsivity (HP:0100710)2.45776921
50* Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44392808
51* Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44392808
52Rhabdomyosarcoma (HP:0002859)2.43695256
53Ependymoma (HP:0002888)2.39689465
54Truncus arteriosus (HP:0001660)2.37671912
55Stridor (HP:0010307)2.37350271
56Secondary amenorrhea (HP:0000869)2.37332540
57Hyperparathyroidism (HP:0000843)2.37134503
58Progressive muscle weakness (HP:0003323)2.36580564
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36540234
60Dicarboxylic aciduria (HP:0003215)2.36540234
61Hepatocellular necrosis (HP:0001404)2.36022814
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.34293372
63Spastic diplegia (HP:0001264)2.33224962
64Selective tooth agenesis (HP:0001592)2.33084376
65Abnormality of fatty-acid metabolism (HP:0004359)2.31864452
66Asymmetry of the thorax (HP:0001555)2.31098841
67Megaloblastic anemia (HP:0001889)2.29502914
68Abnormality of nucleobase metabolism (HP:0010932)2.23533704
69Flat acetabular roof (HP:0003180)2.20743813
70Turricephaly (HP:0000262)2.19925874
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.19438953
72Distal lower limb muscle weakness (HP:0009053)2.18481082
73Bulbar palsy (HP:0001283)2.18086775
74Rectal prolapse (HP:0002035)2.17838986
75Broad distal phalanx of finger (HP:0009836)2.17637285
76Prolonged partial thromboplastin time (HP:0003645)2.15798513
77Testicular atrophy (HP:0000029)2.15465830
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13349715
79Distal lower limb amyotrophy (HP:0008944)2.13197042
80Insomnia (HP:0100785)2.12059026
81Hypoglycemic coma (HP:0001325)2.10089232
82Distal upper limb amyotrophy (HP:0007149)2.09896824
83Upper limb amyotrophy (HP:0009129)2.09896824
84Partial duplication of thumb phalanx (HP:0009944)2.09795527
85Rhabdomyolysis (HP:0003201)2.09506588
86Carpal bone hypoplasia (HP:0001498)2.09191076
87Lipid accumulation in hepatocytes (HP:0006561)2.09103518
88Increased muscle lipid content (HP:0009058)2.08906269
89Abnormality of the thoracic spine (HP:0100711)2.07387888
90Patellar aplasia (HP:0006443)2.07202765
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.07171458
92Vaginal fistula (HP:0004320)2.07139684
93Increased CSF lactate (HP:0002490)2.07099498
94Absent thumb (HP:0009777)2.06042460
95Nausea (HP:0002018)2.04470102
96Acute encephalopathy (HP:0006846)2.03659565
97CNS demyelination (HP:0007305)2.03208456
98Degeneration of anterior horn cells (HP:0002398)2.03027644
99Abnormality of the anterior horn cell (HP:0006802)2.03027644
100Multiple lipomas (HP:0001012)2.02820842
101Aplasia/Hypoplasia of the patella (HP:0006498)2.02397799
102Cerebral hypomyelination (HP:0006808)2.02381079
103Generalized amyotrophy (HP:0003700)2.02142443
104Adenoma sebaceum (HP:0009720)2.02061123
105Angiofibromas (HP:0010615)2.02061123
106Abnormal cartilage morphology (HP:0002763)2.01627145
107Increased intramyocellular lipid droplets (HP:0012240)1.99663965
108Long palpebral fissure (HP:0000637)1.99488047
109Thoracic kyphosis (HP:0002942)1.99420553
110Hypoalphalipoproteinemia (HP:0003233)1.95652679
111Neoplasm of the pancreas (HP:0002894)1.95636550
112Partial duplication of the phalanx of hand (HP:0009999)1.95603214
113Increased serum ferritin (HP:0003281)1.94817588
114Colitis (HP:0002583)1.94648524
115Ketosis (HP:0001946)1.94402830
116Hyperbilirubinemia (HP:0002904)1.93590742
117Microvesicular hepatic steatosis (HP:0001414)1.92593659
118Lactic acidosis (HP:0003128)1.91701544
119Delayed CNS myelination (HP:0002188)1.90458181
120Hyperthyroidism (HP:0000836)1.89548330
121Abnormal trabecular bone morphology (HP:0100671)1.89435116
122Hyperlipoproteinemia (HP:0010980)1.89054797
123Pancytopenia (HP:0001876)1.88850970
124Mitochondrial inheritance (HP:0001427)1.88850835
125Squamous cell carcinoma (HP:0002860)1.88756490
126Ragged-red muscle fibers (HP:0003200)1.88455598
127Easy fatigability (HP:0003388)1.87780078
128Exercise-induced myalgia (HP:0003738)1.86527725
129Hypertensive crisis (HP:0100735)1.85874111
130Polygenic inheritance (HP:0010982)1.84024132
131Thrombocytosis (HP:0001894)1.83987032
132Medulloblastoma (HP:0002885)1.83944062
133Abdominal distention (HP:0003270)1.83690176
134Axonal loss (HP:0003447)1.83206069
135Increased hepatocellular lipid droplets (HP:0006565)1.83046194
136Sparse eyelashes (HP:0000653)1.83010742
137Abnormal spermatogenesis (HP:0008669)1.81537173
138Renal duplication (HP:0000075)1.81026873
139Abnormality of iron homeostasis (HP:0011031)1.80578268
140Nonimmune hydrops fetalis (HP:0001790)1.80338496
141Abnormal mitochondria in muscle tissue (HP:0008316)1.79274350
142Horseshoe kidney (HP:0000085)1.79214378
143Abnormal gallbladder physiology (HP:0012438)1.79094188
144Cholecystitis (HP:0001082)1.79094188
145Abnormality of transition element cation homeostasis (HP:0011030)1.79015572
146Spinal cord lesions (HP:0100561)1.78706289
147Syringomyelia (HP:0003396)1.78706289
148Reticulocytosis (HP:0001923)1.77375482
149Increased connective tissue (HP:0009025)1.76853474
150Disproportionate tall stature (HP:0001519)1.75428074
151Patellar dislocation (HP:0002999)1.74437842
152Self-mutilation (HP:0000742)1.74228887
153Progressive external ophthalmoplegia (HP:0000590)1.74191370
154Elbow flexion contracture (HP:0002987)1.73448271
155Abnormality of carpal bone ossification (HP:0006257)1.72227841
156Deep palmar crease (HP:0006191)1.72001718
157Abnormality of the tricuspid valve (HP:0001702)1.71518639
158Hypercortisolism (HP:0001578)1.71478264
159Gout (HP:0001997)1.70582262
160Hypercalcemia (HP:0003072)1.70414184
161Abnormality of the umbilical cord (HP:0010881)1.70252187
162Thin ribs (HP:0000883)1.69644956
163Protrusio acetabuli (HP:0003179)1.68382595
164Abnormal ossification of hand bones (HP:0005921)1.68274383
165Flattened epiphyses (HP:0003071)1.67544107
166Spinal rigidity (HP:0003306)1.67028691
167Wide cranial sutures (HP:0010537)1.66038810
168Ileus (HP:0002595)1.65687776
169Diaphragmatic weakness (HP:0009113)1.65548747
170Seborrheic dermatitis (HP:0001051)1.65317883
171Malnutrition (HP:0004395)1.64294900
172External ophthalmoplegia (HP:0000544)1.64203631
173Abnormality of the distal phalanx of the thumb (HP:0009617)1.64148413
174Overriding aorta (HP:0002623)1.63955531
175Abnormality of the distal phalanges of the toes (HP:0010182)1.63950540
176Increased variability in muscle fiber diameter (HP:0003557)1.63622455
177Delayed epiphyseal ossification (HP:0002663)1.63509026
178Abnormality of the columella (HP:0009929)1.62588813
179Obstructive sleep apnea (HP:0002870)1.60347865
180Congenital glaucoma (HP:0001087)1.59815675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.97788855
2SMG13.92281163
3NME23.78394490
4WEE13.77980769
5BUB13.74995581
6TLK12.94126041
7BCKDK2.59877898
8ACVR1B2.59756171
9ICK2.52529203
10PRPF4B2.42611386
11NEK22.39517955
12SIK12.23500998
13TESK22.17283150
14TTK2.17089844
15CDC72.16337657
16EPHA22.05256114
17MAP3K112.00002031
18DYRK31.94000960
19SCYL21.88685094
20ARAF1.83451636
21RPS6KA41.75467759
22EIF2AK31.74752107
23NEK11.67946902
24PLK11.67392941
25CDK71.62407327
26STK161.62215670
27RPS6KB21.60550624
28RIPK11.59543074
29FGFR41.51732161
30PKN21.47934011
31BRSK21.46339242
32CDK41.44648747
33TAOK21.41646324
34AURKA1.39512189
35SRPK11.39052272
36MAP3K81.38599449
37AURKB1.38248913
38TESK11.36356202
39PDK41.32276593
40PDK31.32276593
41STK101.26866624
42EEF2K1.26448999
43VRK21.25433731
44MAP3K101.25323133
45VRK11.22296418
46BRSK11.22213140
47CHEK21.20684835
48FLT31.18568669
49MAP3K11.17523238
50PAK41.15083839
51PLK41.13783007
52MST1R1.12598211
53KDR1.11714339
54STK38L1.11649115
55PDPK11.10289341
56MAPKAPK31.07048631
57CDK121.04276874
58TTN1.02994341
59ERN11.01575911
60ATR0.98565769
61TGFBR10.98479312
62PTK60.97831789
63IRAK20.95845372
64PIM20.95505494
65KSR20.94010328
66MKNK10.93974830
67CCNB10.91761291
68PRKG20.89956140
69PRKD30.89839955
70PASK0.88413513
71BRAF0.85658296
72PBK0.83078573
73MAP2K20.80967210
74TRIB30.79885168
75LRRK20.79589874
76PDGFRA0.79457873
77MAPK110.79446141
78TAOK10.79305471
79STK40.78275387
80ABL20.78115113
81PIM10.77945558
82RPS6KA20.76637850
83CHEK10.76070986
84LMTK20.74053710
85PAK10.73686631
86MAP3K130.72900260
87RPS6KC10.72445550
88RPS6KL10.72445550
89MKNK20.71765261
90TSSK60.71488441
91LATS20.69985590
92PDK20.66839657
93MAP3K90.66667851
94CSNK2A20.66097610
95DDR20.64634432
96CDC42BPA0.63666075
97STK30.62651379
98TBK10.61923513
99CSNK2A10.61806991
100TYRO30.60695341
101IRAK30.60466927
102ERBB40.59285608
103CDK20.58948481
104PRKD20.58392384
105BMX0.57670635
106RPS6KA50.55786105
107NME10.55074659
108PLK30.54809467
109MAP4K10.54258780
110EIF2AK20.53179034
111GRK60.53156796
112MAP2K30.53130500
113CDK60.53013416
114PRKCI0.52903467
115MAP3K30.51933894
116ILK0.51883256
117ATM0.51651993
118NEK90.51501453
119DAPK30.49141745
120PTK20.48149186
121CDK11A0.47841339
122MELK0.47688622
123RPS6KA60.47523858
124DYRK20.46655063
125CDK80.45636512
126PDK10.45053358
127MARK20.44445588
128HIPK20.43260712
129CDK140.42488891
130MAPK120.41240665
131MUSK0.40633643
132CDK150.40293472
133ZAK0.39523287
134MTOR0.39282009
135TYK20.37600920
136CDK90.35806660
137CSF1R0.33474015
138RET0.32963874
139MARK30.32677481
140CDK180.31289278
141SIK20.31041324
142AKT20.30935830
143MAP2K60.28895921
144DYRK1B0.28495961
145CDK10.27733154
146RPS6KA10.26748551
147MAP3K50.23583746

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.81637351
2DNA replication_Homo sapiens_hsa030303.31019273
3One carbon pool by folate_Homo sapiens_hsa006702.79349448
4Mismatch repair_Homo sapiens_hsa034302.70997391
5Other glycan degradation_Homo sapiens_hsa005112.67985713
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52105929
7Proteasome_Homo sapiens_hsa030502.40366627
8RNA polymerase_Homo sapiens_hsa030202.13076010
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10626132
10Spliceosome_Homo sapiens_hsa030402.09337880
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.07781345
12Folate biosynthesis_Homo sapiens_hsa007902.03428337
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02938342
14Sulfur relay system_Homo sapiens_hsa041222.02188619
15RNA transport_Homo sapiens_hsa030131.99845883
16Pyrimidine metabolism_Homo sapiens_hsa002401.95006642
17Homologous recombination_Homo sapiens_hsa034401.86401832
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.79822719
19Base excision repair_Homo sapiens_hsa034101.79594346
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.75621007
21Nucleotide excision repair_Homo sapiens_hsa034201.70467222
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.69920567
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69325014
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.68972026
25Biosynthesis of amino acids_Homo sapiens_hsa012301.67087663
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64975526
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.61903862
28Selenocompound metabolism_Homo sapiens_hsa004501.59389339
29Pentose phosphate pathway_Homo sapiens_hsa000301.57327147
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.51044726
31Chronic myeloid leukemia_Homo sapiens_hsa052201.49867212
32Acute myeloid leukemia_Homo sapiens_hsa052211.45806940
33Carbon metabolism_Homo sapiens_hsa012001.43435091
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42674417
35Cell cycle_Homo sapiens_hsa041101.41689462
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37375439
37Arginine biosynthesis_Homo sapiens_hsa002201.36381876
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35113960
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31913149
40VEGF signaling pathway_Homo sapiens_hsa043701.30861032
41Fatty acid degradation_Homo sapiens_hsa000711.30239245
42Non-small cell lung cancer_Homo sapiens_hsa052231.28945528
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27030149
44Vitamin B6 metabolism_Homo sapiens_hsa007501.26205207
45Nitrogen metabolism_Homo sapiens_hsa009101.19475105
46Glutathione metabolism_Homo sapiens_hsa004801.18455990
47Notch signaling pathway_Homo sapiens_hsa043301.18134136
48Prion diseases_Homo sapiens_hsa050201.16725598
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14740172
50Fanconi anemia pathway_Homo sapiens_hsa034601.14628601
51Propanoate metabolism_Homo sapiens_hsa006401.12976158
52Pyruvate metabolism_Homo sapiens_hsa006201.11270461
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10222299
54Tryptophan metabolism_Homo sapiens_hsa003801.10139819
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08334472
56Systemic lupus erythematosus_Homo sapiens_hsa053221.07516617
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06074038
58Peroxisome_Homo sapiens_hsa041461.03534929
59Basal transcription factors_Homo sapiens_hsa030221.03496838
60p53 signaling pathway_Homo sapiens_hsa041151.02254081
61Arginine and proline metabolism_Homo sapiens_hsa003301.02120270
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.00656707
63N-Glycan biosynthesis_Homo sapiens_hsa005100.98843060
64Chemical carcinogenesis_Homo sapiens_hsa052040.98688731
65Insulin signaling pathway_Homo sapiens_hsa049100.97705691
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95070046
67Apoptosis_Homo sapiens_hsa042100.94963789
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94682792
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94350315
70Vibrio cholerae infection_Homo sapiens_hsa051100.92815219
71beta-Alanine metabolism_Homo sapiens_hsa004100.91002479
72Fat digestion and absorption_Homo sapiens_hsa049750.89801571
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89408041
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89285652
75Endometrial cancer_Homo sapiens_hsa052130.89051439
76Pancreatic cancer_Homo sapiens_hsa052120.88544544
77RNA degradation_Homo sapiens_hsa030180.87237533
78Complement and coagulation cascades_Homo sapiens_hsa046100.85448834
79B cell receptor signaling pathway_Homo sapiens_hsa046620.85192649
80Purine metabolism_Homo sapiens_hsa002300.84770388
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83246397
82Retinol metabolism_Homo sapiens_hsa008300.82503273
83Non-homologous end-joining_Homo sapiens_hsa034500.82366393
84Caffeine metabolism_Homo sapiens_hsa002320.81792267
85AMPK signaling pathway_Homo sapiens_hsa041520.80895502
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80022053
87mTOR signaling pathway_Homo sapiens_hsa041500.79578693
88Huntingtons disease_Homo sapiens_hsa050160.79409102
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78543374
90Fructose and mannose metabolism_Homo sapiens_hsa000510.78334397
91Parkinsons disease_Homo sapiens_hsa050120.78138969
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78015509
93Hepatitis C_Homo sapiens_hsa051600.77270276
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77259285
95Butanoate metabolism_Homo sapiens_hsa006500.75875331
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75226269
97Histidine metabolism_Homo sapiens_hsa003400.73484240
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.72773389
99Renin-angiotensin system_Homo sapiens_hsa046140.72514447
100Phenylalanine metabolism_Homo sapiens_hsa003600.70171023
101Fatty acid metabolism_Homo sapiens_hsa012120.70004991
102Oxidative phosphorylation_Homo sapiens_hsa001900.68940966
103PPAR signaling pathway_Homo sapiens_hsa033200.68527580
104Lysosome_Homo sapiens_hsa041420.65960019
105Metabolic pathways_Homo sapiens_hsa011000.65088063
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62239250
107Glioma_Homo sapiens_hsa052140.62060207
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.59482543
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.59006688
110ErbB signaling pathway_Homo sapiens_hsa040120.58812193
111Sphingolipid metabolism_Homo sapiens_hsa006000.58800311
112Tyrosine metabolism_Homo sapiens_hsa003500.58704096
113mRNA surveillance pathway_Homo sapiens_hsa030150.58683169
114HTLV-I infection_Homo sapiens_hsa051660.58171007
115Galactose metabolism_Homo sapiens_hsa000520.57550253
116Vitamin digestion and absorption_Homo sapiens_hsa049770.53995284
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52292862
118Linoleic acid metabolism_Homo sapiens_hsa005910.50917163
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50779656
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49960984
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49226176
122Shigellosis_Homo sapiens_hsa051310.49105880
123Insulin resistance_Homo sapiens_hsa049310.48812130
124Alcoholism_Homo sapiens_hsa050340.48652651
125Hepatitis B_Homo sapiens_hsa051610.48055595
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.47626812
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47457331
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47342797
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46226449
130Glucagon signaling pathway_Homo sapiens_hsa049220.45737995
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45168375
132Renal cell carcinoma_Homo sapiens_hsa052110.44529890
133Sulfur metabolism_Homo sapiens_hsa009200.44186496
134Prostate cancer_Homo sapiens_hsa052150.44144244
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44044644
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43868988
137Epstein-Barr virus infection_Homo sapiens_hsa051690.43626810
138Starch and sucrose metabolism_Homo sapiens_hsa005000.40388706
139Endocytosis_Homo sapiens_hsa041440.40181158
140Lysine degradation_Homo sapiens_hsa003100.39182484
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.39070425
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37861193
143Viral carcinogenesis_Homo sapiens_hsa052030.36109080
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36037631
145Small cell lung cancer_Homo sapiens_hsa052220.35493471
146Bladder cancer_Homo sapiens_hsa052190.35134707
147Protein export_Homo sapiens_hsa030600.35090051
148Herpes simplex infection_Homo sapiens_hsa051680.33473489
149Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33452209
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31950586
151Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28119210
152Thyroid cancer_Homo sapiens_hsa052160.23692635
153Staphylococcus aureus infection_Homo sapiens_hsa051500.23645290

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