GFI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.51030708
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.51030708
3positive regulation of gamma-delta T cell activation (GO:0046645)5.21431325
4regulation of gamma-delta T cell differentiation (GO:0045586)4.73153398
5antigen processing and presentation of endogenous antigen (GO:0019883)4.61693279
6ribosomal small subunit assembly (GO:0000028)4.55289747
7leukocyte aggregation (GO:0070486)4.49954432
8cellular extravasation (GO:0045123)4.38953897
9negative regulation of phagocytosis (GO:0050765)4.35957355
10regulation of gamma-delta T cell activation (GO:0046643)4.24535938
11Peyers patch development (GO:0048541)4.23108397
12mucosal-associated lymphoid tissue development (GO:0048537)4.23108397
13positive regulation of B cell differentiation (GO:0045579)4.01116640
14antigen processing and presentation via MHC class Ib (GO:0002475)3.96526923
15negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.92545996
16negative T cell selection (GO:0043383)3.86682017
17positive thymic T cell selection (GO:0045059)3.82132922
18viral transcription (GO:0019083)3.80734821
19neutrophil mediated immunity (GO:0002446)3.76125538
20response to fungus (GO:0009620)3.72295334
21B cell receptor signaling pathway (GO:0050853)3.71933991
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.70950375
23killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.70509266
24disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.70509266
25negative thymic T cell selection (GO:0045060)3.69018471
26DNA unwinding involved in DNA replication (GO:0006268)3.68754329
27translational termination (GO:0006415)3.67399459
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64535091
29defense response to fungus (GO:0050832)3.63132105
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.60395168
31regulation of interleukin-12 biosynthetic process (GO:0045075)3.57609300
32regulation of granulocyte differentiation (GO:0030852)3.52522768
33negative regulation of T cell mediated immunity (GO:0002710)3.46945244
34positive T cell selection (GO:0043368)3.45707648
35T cell homeostasis (GO:0043029)3.43671959
36positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.41434660
37definitive hemopoiesis (GO:0060216)3.33324420
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32810739
39response to muramyl dipeptide (GO:0032495)3.31372414
40translational elongation (GO:0006414)3.28730801
41innate immune response in mucosa (GO:0002227)3.27500160
42poly(A)+ mRNA export from nucleus (GO:0016973)3.26861464
433-UTR-mediated mRNA stabilization (GO:0070935)3.26467530
44modulation of growth of symbiont involved in interaction with host (GO:0044144)3.26288511
45regulation of growth of symbiont in host (GO:0044126)3.26288511
46negative regulation of growth of symbiont in host (GO:0044130)3.26288511
47negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.26288511
48regulation of B cell differentiation (GO:0045577)3.26214865
49response to interleukin-15 (GO:0070672)3.25762223
50cotranslational protein targeting to membrane (GO:0006613)3.24319950
51myeloid dendritic cell activation (GO:0001773)3.24300832
52protein targeting to ER (GO:0045047)3.24284704
53pentose-phosphate shunt (GO:0006098)3.19958779
54mannose metabolic process (GO:0006013)3.19283314
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16813751
56negative regulation of cell killing (GO:0031342)3.16813751
57T cell selection (GO:0045058)3.14255213
58activated T cell proliferation (GO:0050798)3.13975340
59positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12831130
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11666078
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10439007
62thymic T cell selection (GO:0045061)3.08548055
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.07763580
64regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.05361236
65regulation of natural killer cell mediated immunity (GO:0002715)3.05361236
66megakaryocyte development (GO:0035855)3.03451778
67positive regulation of alpha-beta T cell proliferation (GO:0046641)3.02541669
68protein localization to endoplasmic reticulum (GO:0070972)3.02501281
69regulation of alpha-beta T cell proliferation (GO:0046640)3.02362720
70myeloid dendritic cell differentiation (GO:0043011)3.01058278
71myeloid leukocyte mediated immunity (GO:0002444)3.00552288
72mast cell activation (GO:0045576)2.98113894
73response to protozoan (GO:0001562)2.97901075
74negative regulation of erythrocyte differentiation (GO:0045647)2.96228596
75T cell migration (GO:0072678)2.95042831
76interferon-gamma production (GO:0032609)2.93376949
77negative regulation of lymphocyte mediated immunity (GO:0002707)2.92205973
78NIK/NF-kappaB signaling (GO:0038061)2.89895752
79maturation of SSU-rRNA (GO:0030490)2.89589001
80regulation of B cell receptor signaling pathway (GO:0050855)2.88768031
81natural killer cell differentiation (GO:0001779)2.88086950
82viral life cycle (GO:0019058)2.85266325
83CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.84457584
84translational initiation (GO:0006413)2.81159927
85ribosomal small subunit biogenesis (GO:0042274)2.81032345
86cellular protein complex disassembly (GO:0043624)2.80329217
87positive regulation of natural killer cell mediated immunity (GO:0002717)2.80232485
88leukocyte degranulation (GO:0043299)2.79199882
89detection of bacterium (GO:0016045)2.78552164
90DNA strand elongation involved in DNA replication (GO:0006271)2.78509136
91IMP metabolic process (GO:0046040)2.77660219
92regulation of regulatory T cell differentiation (GO:0045589)2.77642154
93neutrophil activation involved in immune response (GO:0002283)2.77606216
94regulation of tolerance induction (GO:0002643)2.76477079
95respiratory burst (GO:0045730)2.75456836
96histone H3-K36 demethylation (GO:0070544)2.74824757
97B cell homeostasis (GO:0001782)2.74645625
98positive regulation of isotype switching (GO:0045830)2.74121373
99cellular response to interleukin-4 (GO:0071353)2.73135442
100NADPH regeneration (GO:0006740)2.72669312
101lymphocyte homeostasis (GO:0002260)2.71491789
102positive regulation of tolerance induction (GO:0002645)2.70809470
103regulation of interleukin-2 biosynthetic process (GO:0045076)2.70769605
104positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.70342929
105detection of other organism (GO:0098543)2.70200956
106defense response to protozoan (GO:0042832)2.70174078
107positive regulation of B cell activation (GO:0050871)2.69686468
108G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.69390124
109disruption of cells of other organism (GO:0044364)2.69356832
110killing of cells of other organism (GO:0031640)2.69356832
111regulation of isotype switching to IgG isotypes (GO:0048302)2.68897554
112T cell receptor signaling pathway (GO:0050852)2.68204963
113telomere maintenance via semi-conservative replication (GO:0032201)2.67626178
114negative regulation of RNA splicing (GO:0033119)2.67211241
115DNA strand elongation (GO:0022616)2.67120663
116mucosal immune response (GO:0002385)2.66656850
117negative regulation of leukocyte mediated immunity (GO:0002704)2.66286021
118positive regulation of natural killer cell differentiation (GO:0032825)2.64979927
119immunoglobulin mediated immune response (GO:0016064)2.63509411
120protein localization to kinetochore (GO:0034501)2.62914394
121negative regulation of interleukin-12 production (GO:0032695)2.62227500
122lymphocyte migration (GO:0072676)2.61919807
123IMP biosynthetic process (GO:0006188)2.61870395
124organ or tissue specific immune response (GO:0002251)2.60427089
125protein complex disassembly (GO:0043241)2.59053287
126T cell proliferation (GO:0042098)2.58789069
127positive regulation of interleukin-2 production (GO:0032743)2.58704475
128antibacterial humoral response (GO:0019731)2.58182477
129response to peptidoglycan (GO:0032494)2.57780395
130mast cell activation involved in immune response (GO:0002279)2.57518732
131mast cell degranulation (GO:0043303)2.57518732
132regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57465089
133regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.56301464
134cellular response to zinc ion (GO:0071294)2.56300881
135regulation of histone H3-K27 methylation (GO:0061085)2.55658150
136leukocyte homeostasis (GO:0001776)2.55303585
137modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.54799045
138positive regulation by organism of defense response of other organism involved in symbiotic interact2.54799045
139modulation by symbiont of host immune response (GO:0052553)2.54799045
140positive regulation by symbiont of host defense response (GO:0052509)2.54799045
141modulation by symbiont of host defense response (GO:0052031)2.54799045
142modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.54799045
143tolerance induction (GO:0002507)2.54364642
144positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.53923874
145positive regulation of granulocyte differentiation (GO:0030854)2.53908367
146necroptotic process (GO:0070266)2.53636029
147antigen receptor-mediated signaling pathway (GO:0050851)2.52874323
148cellular response to interleukin-15 (GO:0071350)2.52245118
149T cell lineage commitment (GO:0002360)2.52183747
150positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.51719587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.09838576
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.57812412
3MYC_22102868_ChIP-Seq_BL_Human3.40019037
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32877267
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07963005
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.07662444
7* VDR_21846776_ChIP-Seq_THP-1_Human3.04670119
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00173224
9* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.86965290
10SCL_19346495_ChIP-Seq_HPC-7_Human2.84220818
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.75997512
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.56772320
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55785939
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49186658
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39176523
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39102141
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.35962907
18* MYB_26560356_Chip-Seq_TH2_Human2.31125487
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27195345
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.24443604
21* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.18384693
22SPI1_23547873_ChIP-Seq_NB4_Human2.14941734
23* MAF_26560356_Chip-Seq_TH1_Human2.14285019
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.14160252
25* VDR_24763502_ChIP-Seq_THP-1_Human2.07387151
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06543394
27* UTX_26944678_Chip-Seq_JUKART_Human2.04399694
28MYB_26560356_Chip-Seq_TH1_Human2.04132551
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95323023
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94662103
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88283539
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87919391
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.86859419
34TCF7_22412390_ChIP-Seq_EML_Mouse1.85222097
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.84352352
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82999360
37* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82395174
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.81951893
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80141530
40CIITA_25753668_ChIP-Seq_RAJI_Human1.80013711
41RUNX_20019798_ChIP-Seq_JUKART_Human1.78905417
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77759286
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77538881
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77355276
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76291860
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.75077040
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72843128
48VDR_23849224_ChIP-Seq_CD4+_Human1.63065616
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60336109
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59546811
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57144572
52FOXP3_21729870_ChIP-Seq_TREG_Human1.56919098
53* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53735602
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52234674
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50346295
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.48174301
57GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.45709591
58* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45529203
59MAF_26560356_Chip-Seq_TH2_Human1.45159217
60XRN2_22483619_ChIP-Seq_HELA_Human1.44823028
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44113839
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.42781188
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42087354
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41856447
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.40334253
66* IRF8_27001747_Chip-Seq_BMDM_Mouse1.38802459
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37849744
68* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36239099
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35514379
70* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33445367
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.32942672
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29539851
73* GATA3_27048872_Chip-Seq_THYMUS_Human1.28176967
74SPI1_23127762_ChIP-Seq_K562_Human1.22834326
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21134825
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17467115
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15989965
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14354692
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13223015
80NCOR1_26117541_ChIP-Seq_K562_Human1.12577029
81* LXR_22292898_ChIP-Seq_THP-1_Human1.11196426
82* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10874407
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10808524
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10467351
85ELK1_19687146_ChIP-ChIP_HELA_Human1.10252382
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09541382
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08552054
88* GATA3_26560356_Chip-Seq_TH2_Human1.08448403
89GABP_19822575_ChIP-Seq_HepG2_Human1.07808344
90KDM5A_27292631_Chip-Seq_BREAST_Human1.07444038
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.06949927
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06890909
93PU_27001747_Chip-Seq_BMDM_Mouse1.06788589
94* KDM2B_26808549_Chip-Seq_DND41_Human1.06647288
95* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04936691
96JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04871909
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02931412
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01579522
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.01458746
100TTF2_22483619_ChIP-Seq_HELA_Human0.99858361
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.99825172
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99279875
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98970566
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98921424
105DCP1A_22483619_ChIP-Seq_HELA_Human0.97451883
106ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96214199
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96196143
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95468697
109AR_21909140_ChIP-Seq_LNCAP_Human0.95436685
110TFEB_21752829_ChIP-Seq_HELA_Human0.92733053
111PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89941657
112* VDR_24787735_ChIP-Seq_THP-1_Human0.89755530
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89622691
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89562164
115MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89240548
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89234479
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89232269
118GATA1_22025678_ChIP-Seq_K562_Human0.88952351
119BCL6_27268052_Chip-Seq_Bcells_Human0.88201355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.44685106
2MP0002396_abnormal_hematopoietic_system3.34768230
3MP0003303_peritoneal_inflammation3.31487656
4MP0003436_decreased_susceptibility_to3.24241388
5MP0000685_abnormal_immune_system3.19045764
6MP0005671_abnormal_response_to3.18538348
7MP0001835_abnormal_antigen_presentation3.13423607
8MP0009785_altered_susceptibility_to2.84721410
9MP0004808_abnormal_hematopoietic_stem2.76339027
10MP0001800_abnormal_humoral_immune2.59497766
11MP0002398_abnormal_bone_marrow2.59349779
12MP0002166_altered_tumor_susceptibility2.56070977
13MP0005025_abnormal_response_to2.42764799
14MP0005000_abnormal_immune_tolerance2.39842411
15MP0005464_abnormal_platelet_physiology2.39296702
16* MP0002420_abnormal_adaptive_immunity2.39020689
17* MP0001819_abnormal_immune_cell2.34614396
18MP0003300_gastrointestinal_ulcer2.30540275
19MP0003693_abnormal_embryo_hatching2.30384878
20MP0001790_abnormal_immune_system2.29589286
21MP0005387_immune_system_phenotype2.29589286
22MP0002452_abnormal_antigen_presenting2.27731867
23* MP0002723_abnormal_immune_serum2.26868442
24MP0005451_abnormal_body_composition2.22073242
25MP0002419_abnormal_innate_immunity2.19875800
26* MP0000716_abnormal_immune_system2.17238487
27MP0003866_abnormal_defecation2.16107346
28* MP0000703_abnormal_thymus_morphology2.14960992
29MP0010155_abnormal_intestine_physiology2.14812945
30MP0002405_respiratory_system_inflammati2.14699398
31* MP0002722_abnormal_immune_system2.14418062
32MP0000465_gastrointestinal_hemorrhage2.11775455
33MP0009333_abnormal_splenocyte_physiolog2.11173736
34MP0000689_abnormal_spleen_morphology2.07728691
35MP0001545_abnormal_hematopoietic_system2.06100881
36MP0005397_hematopoietic_system_phenotyp2.06100881
37MP0002006_tumorigenesis2.03106524
38MP0008057_abnormal_DNA_replication2.02438695
39MP0000490_abnormal_crypts_of1.99009169
40MP0010094_abnormal_chromosome_stability1.94525143
41* MP0002429_abnormal_blood_cell1.92366205
42MP0001873_stomach_inflammation1.89647579
43MP0002148_abnormal_hypersensitivity_rea1.88310164
44MP0001853_heart_inflammation1.87226694
45MP0009278_abnormal_bone_marrow1.75556681
46MP0005174_abnormal_tail_pigmentation1.75388666
47MP0003724_increased_susceptibility_to1.74637617
48MP0002009_preneoplasia1.69681914
49MP0004381_abnormal_hair_follicle1.61538269
50MP0003077_abnormal_cell_cycle1.60360076
51* MP0001845_abnormal_inflammatory_respons1.56874361
52MP0003111_abnormal_nucleus_morphology1.48167123
53MP0003172_abnormal_lysosome_physiology1.46444293
54MP0004185_abnormal_adipocyte_glucose1.44698324
55MP0005075_abnormal_melanosome_morpholog1.44489040
56MP0004957_abnormal_blastocyst_morpholog1.43518032
57MP0003183_abnormal_peptide_metabolism1.35477659
58MP0004947_skin_inflammation1.35360907
59MP0001533_abnormal_skeleton_physiology1.34912544
60MP0002019_abnormal_tumor_incidence1.33701092
61MP0010307_abnormal_tumor_latency1.27952386
62MP0010352_gastrointestinal_tract_polyps1.26882416
63MP0000858_altered_metastatic_potential1.23811214
64MP0000569_abnormal_digit_pigmentation1.23133441
65MP0002933_joint_inflammation1.20377371
66MP0001851_eye_inflammation1.14785046
67MP0008058_abnormal_DNA_repair1.14698091
68MP0002132_abnormal_respiratory_system1.09476989
69MP0002095_abnormal_skin_pigmentation1.06471986
70MP0006082_CNS_inflammation1.04999897
71MP0008469_abnormal_protein_level1.03449938
72MP0000015_abnormal_ear_pigmentation0.98785685
73MP0002138_abnormal_hepatobiliary_system0.97621787
74MP0001663_abnormal_digestive_system0.97454710
75MP0008007_abnormal_cellular_replicative0.96783916
76MP0000313_abnormal_cell_death0.94339189
77MP0009379_abnormal_foot_pigmentation0.92350275
78MP0005310_abnormal_salivary_gland0.90589295
79MP0000350_abnormal_cell_proliferation0.88589620
80MP0004510_myositis0.88185573
81MP0005076_abnormal_cell_differentiation0.85787452
82MP0008260_abnormal_autophagy0.85502928
83MP0001986_abnormal_taste_sensitivity0.79741461
84MP0003221_abnormal_cardiomyocyte_apopto0.78968620
85MP0003828_pulmonary_edema0.76975920
86MP0009115_abnormal_fat_cell0.74743718
87MP0003448_altered_tumor_morphology0.72069875
88MP0003191_abnormal_cellular_cholesterol0.71772368
89MP0008961_abnormal_basal_metabolism0.71377702
90MP0009765_abnormal_xenobiotic_induced0.71206465
91MP0002089_abnormal_postnatal_growth/wei0.70967281
92MP0005666_abnormal_adipose_tissue0.69230028
93MP0003943_abnormal_hepatobiliary_system0.67475110
94MP0002877_abnormal_melanocyte_morpholog0.66746181
95MP0000477_abnormal_intestine_morphology0.66455879
96MP0006054_spinal_hemorrhage0.65850622
97MP0001730_embryonic_growth_arrest0.64146083
98MP0000343_altered_response_to0.63374832
99MP0005220_abnormal_exocrine_pancreas0.62268768
100MP0008873_increased_physiological_sensi0.61394909
101MP0005058_abnormal_lysosome_morphology0.61325375
102MP0005360_urolithiasis0.60662780
103MP0002163_abnormal_gland_morphology0.58591978
104MP0009763_increased_sensitivity_to0.57983054
105MP0000609_abnormal_liver_physiology0.57010676
106MP0002080_prenatal_lethality0.54772805
107MP0000249_abnormal_blood_vessel0.54557143
108MP0003795_abnormal_bone_structure0.53952855
109MP0002970_abnormal_white_adipose0.53159653
110MP0005621_abnormal_cell_physiology0.51460623
111MP0000371_diluted_coat_color0.51180188
112MP0003656_abnormal_erythrocyte_physiolo0.50957280
113MP0002998_abnormal_bone_remodeling0.49822872
114MP0005390_skeleton_phenotype0.49162209
115MP0000598_abnormal_liver_morphology0.48077660
116MP0005381_digestive/alimentary_phenotyp0.46266783
117MP0009931_abnormal_skin_appearance0.45267559
118MP0005409_darkened_coat_color0.44389700
119MP0005023_abnormal_wound_healing0.44378910
120MP0003786_premature_aging0.44146105

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.93549809
2Eczematoid dermatitis (HP:0000976)5.53548984
3Panhypogammaglobulinemia (HP:0003139)4.29749902
4Recurrent fungal infections (HP:0002841)4.25506940
5Elevated erythrocyte sedimentation rate (HP:0003565)4.20921379
6Recurrent abscess formation (HP:0002722)4.12678584
7IgM deficiency (HP:0002850)4.11948107
8Recurrent viral infections (HP:0004429)4.06633766
9T lymphocytopenia (HP:0005403)4.06613015
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.02970090
11Abnormality of T cells (HP:0002843)3.91414501
12Chronic otitis media (HP:0000389)3.83339192
13Chronic obstructive pulmonary disease (HP:0006510)3.82099085
14Obstructive lung disease (HP:0006536)3.82099085
15Abnormality of T cell number (HP:0011839)3.81635770
16Recurrent bacterial skin infections (HP:0005406)3.77264854
17Meningitis (HP:0001287)3.64427514
18Stomatitis (HP:0010280)3.60799594
19Myositis (HP:0100614)3.56755509
20Chest pain (HP:0100749)3.54631396
21Abnormality of T cell physiology (HP:0011840)3.54165029
22Severe combined immunodeficiency (HP:0004430)3.43332061
23Eosinophilia (HP:0001880)3.34418885
24Autoimmune hemolytic anemia (HP:0001890)3.31995467
25Nasal polyposis (HP:0100582)3.22920977
26Chronic diarrhea (HP:0002028)3.22913693
27Recurrent bronchitis (HP:0002837)3.21697934
28Granulocytopenia (HP:0001913)3.21455673
29Abnormality of cells of the erythroid lineage (HP:0012130)3.20791147
30Aplastic anemia (HP:0001915)3.19630916
31IgG deficiency (HP:0004315)3.19250994
32Increased IgM level (HP:0003496)3.15405790
33Reticulocytopenia (HP:0001896)3.10953441
34Combined immunodeficiency (HP:0005387)3.08067075
35Chronic mucocutaneous candidiasis (HP:0002728)3.04590723
36Recurrent cutaneous fungal infections (HP:0011370)3.04590723
37Thyroiditis (HP:0100646)3.03587414
38Abnormal number of erythroid precursors (HP:0012131)3.01596905
39Amaurosis fugax (HP:0100576)3.00024782
40Hypoplasia of the thymus (HP:0000778)2.96804596
41Recurrent skin infections (HP:0001581)2.96525195
42Abnormality of eosinophils (HP:0001879)2.95139473
43* B lymphocytopenia (HP:0010976)2.90194840
44* Abnormality of B cell number (HP:0010975)2.90194840
45Spontaneous hematomas (HP:0007420)2.89873261
46Cellulitis (HP:0100658)2.87723133
47Mediastinal lymphadenopathy (HP:0100721)2.86829679
48Abnormality of the prostate (HP:0008775)2.85657317
49Poikiloderma (HP:0001029)2.84216979
50Abnormality of the nasal mucosa (HP:0000433)2.80924964
51Epistaxis (HP:0000421)2.80558231
52Leukocytosis (HP:0001974)2.78988236
53Petechiae (HP:0000967)2.72817718
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.70022151
55Lymphopenia (HP:0001888)2.69940729
56Gastrointestinal inflammation (HP:0004386)2.66718362
57Colitis (HP:0002583)2.64923289
58Lymphoma (HP:0002665)2.63961808
59Periodontitis (HP:0000704)2.62490581
60Autoimmune thrombocytopenia (HP:0001973)2.62414803
61Vasculitis (HP:0002633)2.61959248
62Arterial thrombosis (HP:0004420)2.57612685
63Abnormality of the fingertips (HP:0001211)2.55451564
64Abnormal platelet function (HP:0011869)2.52212903
65Impaired platelet aggregation (HP:0003540)2.52212903
66Abnormality of macrophages (HP:0004311)2.51007443
67Inflammation of the large intestine (HP:0002037)2.50856939
68Acute hepatic failure (HP:0006554)2.47968811
69Increased IgE level (HP:0003212)2.47922862
70Prolonged bleeding time (HP:0003010)2.45646311
71Recurrent gram-negative bacterial infections (HP:0005420)2.42475843
72Hypochromic anemia (HP:0001931)2.39699207
73Hemoptysis (HP:0002105)2.38347100
74Papilledema (HP:0001085)2.36198208
75Basal cell carcinoma (HP:0002671)2.35985137
76Osteomyelitis (HP:0002754)2.35667288
77Increased density of long bones (HP:0006392)2.34746368
78Myelodysplasia (HP:0002863)2.32261769
79Thoracic kyphosis (HP:0002942)2.30602661
80Gastrointestinal infarctions (HP:0005244)2.30283468
81Abnormality of the thoracic spine (HP:0100711)2.30074032
82Gingival bleeding (HP:0000225)2.28788029
83Entropion (HP:0000621)2.24213221
84Skin rash (HP:0000988)2.23737943
85Hypergammaglobulinemia (HP:0010702)2.23737548
86Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16655697
87Pulmonary infiltrates (HP:0002113)2.16647804
88Encephalitis (HP:0002383)2.16297344
89Optic neuritis (HP:0100653)2.13353128
90Retrobulbar optic neuritis (HP:0100654)2.13353128
91IgA deficiency (HP:0002720)2.12785645
92Cutaneous melanoma (HP:0012056)2.12148966
93Pustule (HP:0200039)2.12036852
94Viral hepatitis (HP:0006562)2.10904392
95Urticaria (HP:0001025)2.08072438
96Fatigue (HP:0012378)2.07721587
97Skin ulcer (HP:0200042)2.06143714
98Orchitis (HP:0100796)2.05450824
99Aplasia/Hypoplasia of the thymus (HP:0010515)2.03249912
100Agammaglobulinemia (HP:0004432)2.02685117
101Chromsome breakage (HP:0040012)2.01120531
102* Acute myeloid leukemia (HP:0004808)2.01089730
103Gingivitis (HP:0000230)2.00869598
104Pulmonary embolism (HP:0002204)1.99999855
105Pallor (HP:0000980)1.99122719
106Abnormality of the columella (HP:0009929)1.98968716
107Interstitial pulmonary disease (HP:0006530)1.98106254
108Acute lymphatic leukemia (HP:0006721)1.97537519
109Hepatitis (HP:0012115)1.96682806
110Abnormal platelet volume (HP:0011876)1.96188534
111Sepsis (HP:0100806)1.95064019
112Abnormality of the thymus (HP:0000777)1.94605180
113Prominent nose (HP:0000448)1.94291461
114Abnormality of DNA repair (HP:0003254)1.93706593
115Ureteral stenosis (HP:0000071)1.93363776
116Papilloma (HP:0012740)1.93283157
117Verrucae (HP:0200043)1.93283157
118Abnormality of male internal genitalia (HP:0000022)1.92100166
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90741814
120Hypoproteinemia (HP:0003075)1.90514013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.80747155
2EEF2K3.80343376
3PRPF4B3.36347611
4TXK3.24934878
5ZAP703.04737400
6BTK2.42930099
7IRAK42.41221576
8JAK32.36428245
9TEC2.32394358
10PKN22.31947673
11GRK62.01141351
12BLK1.87946627
13SMG11.81589569
14ITK1.81314165
15SYK1.73673044
16NEK21.71109808
17FES1.69614944
18STK101.67745084
19EPHB11.60803514
20MAP2K31.56770800
21CDC71.55983261
22TYK21.52808949
23MAP3K131.52484110
24TAOK31.50975110
25CLK11.48430322
26LRRK21.40252129
27TRIB31.39463371
28PIK3CG1.39000782
29MAP3K101.37923902
30KIT1.36537018
31BRD41.36273119
32PIM21.35797771
33FLT31.34159374
34LCK1.32068065
35WEE11.22961785
36PASK1.22109783
37SIK31.20732120
38RPS6KB21.20020744
39MAP3K141.19398755
40HCK1.19213966
41PIM11.19119239
42NLK1.18835297
43MAP3K111.18122416
44TGFBR11.17153120
45TESK21.16126831
46ICK1.12714948
47CSF1R1.12067026
48NME21.09532279
49IKBKE1.07715349
50RPS6KA41.04281132
51TBK11.01937571
52TNK21.00959968
53ERN10.99838084
54STK160.95005216
55CSK0.94553489
56CDK120.94340667
57TAOK10.92044091
58TSSK60.89308663
59CDK40.89253279
60MAP3K80.87962475
61IKBKB0.87752278
62ATR0.87531381
63NEK90.86028830
64SIK20.85137531
65LYN0.84112724
66MAPK40.81927469
67RIPK40.81630734
68MARK30.81424963
69ALK0.79142861
70EIF2AK30.78022523
71JAK10.77825003
72HIPK20.75532549
73MAP3K10.74147418
74JAK20.72357893
75KSR20.72220337
76STK40.70121210
77MARK20.67910570
78SCYL20.66937971
79TESK10.65475747
80FGFR30.65283981
81MKNK10.64942453
82IRAK30.64779095
83KDR0.64319088
84PTK60.63162132
85CHUK0.62770699
86MAPKAPK30.61528766
87SRPK10.60940085
88TRPM70.59949886
89FGFR40.58940415
90ACVR1B0.56183852
91PAK40.53924998
92MAPK120.53269994
93MAP2K60.52613187
94RPS6KA60.52168431
95RET0.52026304
96AURKB0.51395873
97CDK70.50803694
98IRAK10.49803333
99MAP3K70.49587958
100MATK0.49402563
101BMPR20.49190538
102CDK60.49027615
103PRKCQ0.48706737
104RAF10.47342107
105MAPKAPK20.47029307
106TNIK0.47028234
107MKNK20.44720624
108CCNB10.44071602
109TGFBR20.42957044
110CHEK10.42257678
111TAOK20.41689079
112RPS6KC10.41457341
113RPS6KL10.41457341
114MAP3K120.41323498
115MST40.40627715
116RPS6KA50.39674874
117MAP3K60.39524845
118IRAK20.39296045
119CAMKK10.38774745
120BRSK20.38766353
121TLK10.38148420
122MAPK30.37956693
123PDK10.37189657
124MELK0.36833272
125CDK90.36739631
126MAPK110.35774918
127PDPK10.35363965
128CDK80.35080824

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.70377696
2DNA replication_Homo sapiens_hsa030303.18089588
3Ribosome_Homo sapiens_hsa030102.64310609
4Leishmaniasis_Homo sapiens_hsa051402.40882881
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.17799061
6Mismatch repair_Homo sapiens_hsa034302.16223206
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.09078628
8Base excision repair_Homo sapiens_hsa034102.06546553
9T cell receptor signaling pathway_Homo sapiens_hsa046602.03285203
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02240279
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.00020109
12Antigen processing and presentation_Homo sapiens_hsa046121.98287632
13Non-homologous end-joining_Homo sapiens_hsa034501.93301563
14Measles_Homo sapiens_hsa051621.91910122
15B cell receptor signaling pathway_Homo sapiens_hsa046621.83879292
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79970734
17Osteoclast differentiation_Homo sapiens_hsa043801.72207887
18Spliceosome_Homo sapiens_hsa030401.70530928
19Allograft rejection_Homo sapiens_hsa053301.63475996
20Asthma_Homo sapiens_hsa053101.62131435
21Acute myeloid leukemia_Homo sapiens_hsa052211.58376250
22Herpes simplex infection_Homo sapiens_hsa051681.55720362
23Hematopoietic cell lineage_Homo sapiens_hsa046401.48461980
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47248371
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44517958
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.44078006
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43413775
28Homologous recombination_Homo sapiens_hsa034401.42817979
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.41657101
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37569185
31One carbon pool by folate_Homo sapiens_hsa006701.35901917
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33312586
33Pentose phosphate pathway_Homo sapiens_hsa000301.28228146
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26516891
35Cell cycle_Homo sapiens_hsa041101.22044321
36Legionellosis_Homo sapiens_hsa051341.20142927
37Nucleotide excision repair_Homo sapiens_hsa034201.18774632
38RNA transport_Homo sapiens_hsa030131.17599615
39Toxoplasmosis_Homo sapiens_hsa051451.16096181
40Shigellosis_Homo sapiens_hsa051311.14383009
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.13523061
42Hepatitis B_Homo sapiens_hsa051611.13438994
43Chronic myeloid leukemia_Homo sapiens_hsa052201.13123356
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03611154
45RNA degradation_Homo sapiens_hsa030181.02346917
46N-Glycan biosynthesis_Homo sapiens_hsa005101.01257458
47Influenza A_Homo sapiens_hsa051641.00457090
48HTLV-I infection_Homo sapiens_hsa051660.99024586
49Chemokine signaling pathway_Homo sapiens_hsa040620.96956968
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96855995
51Fanconi anemia pathway_Homo sapiens_hsa034600.96357095
52Epstein-Barr virus infection_Homo sapiens_hsa051690.96270910
53Graft-versus-host disease_Homo sapiens_hsa053320.95731262
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93134049
55Apoptosis_Homo sapiens_hsa042100.93012033
56Thyroid cancer_Homo sapiens_hsa052160.92945088
57Viral carcinogenesis_Homo sapiens_hsa052030.92550830
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92374925
59Platelet activation_Homo sapiens_hsa046110.91988174
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90484827
61Renal cell carcinoma_Homo sapiens_hsa052110.89715330
62Viral myocarditis_Homo sapiens_hsa054160.89160695
63Staphylococcus aureus infection_Homo sapiens_hsa051500.87798565
64Pyrimidine metabolism_Homo sapiens_hsa002400.87321212
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86099454
66Protein export_Homo sapiens_hsa030600.84133829
67Autoimmune thyroid disease_Homo sapiens_hsa053200.83753023
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.82542148
69Tuberculosis_Homo sapiens_hsa051520.81960627
70TNF signaling pathway_Homo sapiens_hsa046680.81290709
71Pertussis_Homo sapiens_hsa051330.80387812
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80062795
73Other glycan degradation_Homo sapiens_hsa005110.79834170
74Pancreatic cancer_Homo sapiens_hsa052120.76770207
75Endometrial cancer_Homo sapiens_hsa052130.75678901
76Prostate cancer_Homo sapiens_hsa052150.75579876
77Non-small cell lung cancer_Homo sapiens_hsa052230.75067066
78mRNA surveillance pathway_Homo sapiens_hsa030150.74509942
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73489338
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72976984
81Salmonella infection_Homo sapiens_hsa051320.72703498
82p53 signaling pathway_Homo sapiens_hsa041150.71386597
83Type I diabetes mellitus_Homo sapiens_hsa049400.68499110
84mTOR signaling pathway_Homo sapiens_hsa041500.67633897
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66387868
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66364095
87VEGF signaling pathway_Homo sapiens_hsa043700.64317057
88Glioma_Homo sapiens_hsa052140.63769279
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63204952
90Alcoholism_Homo sapiens_hsa050340.62765192
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.62225963
92FoxO signaling pathway_Homo sapiens_hsa040680.61918302
93Malaria_Homo sapiens_hsa051440.61100922
94Dorso-ventral axis formation_Homo sapiens_hsa043200.60472725
95Insulin resistance_Homo sapiens_hsa049310.59711927
96Sulfur relay system_Homo sapiens_hsa041220.58929282
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58226059
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.58023470
99African trypanosomiasis_Homo sapiens_hsa051430.57010090
100Choline metabolism in cancer_Homo sapiens_hsa052310.55370362
101Hepatitis C_Homo sapiens_hsa051600.55062500
102Colorectal cancer_Homo sapiens_hsa052100.55042690
103Prolactin signaling pathway_Homo sapiens_hsa049170.54733931
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54718679
105HIF-1 signaling pathway_Homo sapiens_hsa040660.53342228
106Systemic lupus erythematosus_Homo sapiens_hsa053220.53182688
107Inositol phosphate metabolism_Homo sapiens_hsa005620.52940632
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52634896
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.50507479
110Renin-angiotensin system_Homo sapiens_hsa046140.48829045
111Small cell lung cancer_Homo sapiens_hsa052220.47423692
112ErbB signaling pathway_Homo sapiens_hsa040120.47323031
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45355507
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43796485
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42100471
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.37799294
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.36611592
118Lysine degradation_Homo sapiens_hsa003100.35796699
119GnRH signaling pathway_Homo sapiens_hsa049120.35703051
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35136708
121RNA polymerase_Homo sapiens_hsa030200.34629576
122Galactose metabolism_Homo sapiens_hsa000520.33159387
123Proteasome_Homo sapiens_hsa030500.33108255
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.33093807

Most similar genes based on co-expression Upload to Enrichr

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