GFI1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.37523225
2ribosomal small subunit assembly (GO:0000028)7.11080594
3protoporphyrinogen IX metabolic process (GO:0046501)6.10534373
4protoporphyrinogen IX biosynthetic process (GO:0006782)5.83166652
5viral transcription (GO:0019083)5.67225091
6DNA deamination (GO:0045006)5.64530047
7neutrophil activation involved in immune response (GO:0002283)5.62311895
8heme biosynthetic process (GO:0006783)5.54966730
9protein neddylation (GO:0045116)5.52113958
10translational termination (GO:0006415)5.44477145
11blood coagulation, intrinsic pathway (GO:0007597)5.06605041
12ribosomal small subunit biogenesis (GO:0042274)4.92132985
13porphyrin-containing compound biosynthetic process (GO:0006779)4.88025945
14translational elongation (GO:0006414)4.83601402
15erythrocyte maturation (GO:0043249)4.75529470
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.72210825
17oxygen transport (GO:0015671)4.65495171
18cotranslational protein targeting to membrane (GO:0006613)4.60685820
19protein targeting to ER (GO:0045047)4.58751112
20telomere maintenance via semi-conservative replication (GO:0032201)4.57882979
21regulation of platelet aggregation (GO:0090330)4.55986009
22heme metabolic process (GO:0042168)4.50829757
23DNA strand elongation involved in DNA replication (GO:0006271)4.50645376
24platelet aggregation (GO:0070527)4.40105304
25protein localization to endoplasmic reticulum (GO:0070972)4.37771759
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.36935110
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.34699394
28tetrapyrrole biosynthetic process (GO:0033014)4.34546005
29maturation of SSU-rRNA (GO:0030490)4.33722634
30regulation of platelet activation (GO:0010543)4.31755638
31DNA strand elongation (GO:0022616)4.30323401
32DNA replication initiation (GO:0006270)4.22736078
33viral life cycle (GO:0019058)4.20698418
34gas transport (GO:0015669)4.17309721
35cellular protein complex disassembly (GO:0043624)4.16762417
36autophagic vacuole fusion (GO:0000046)4.16693198
37purinergic nucleotide receptor signaling pathway (GO:0035590)4.14015871
38translational initiation (GO:0006413)4.13051544
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.04642453
40angiogenesis involved in wound healing (GO:0060055)4.02811535
41definitive hemopoiesis (GO:0060216)3.97143849
42porphyrin-containing compound metabolic process (GO:0006778)3.96664333
43platelet formation (GO:0030220)3.91451570
44erythrocyte development (GO:0048821)3.87515138
45embryonic hemopoiesis (GO:0035162)3.85636682
46telomere maintenance via recombination (GO:0000722)3.82349579
47positive regulation of mast cell activation (GO:0033005)3.77165004
48proteasome assembly (GO:0043248)3.74564557
49DNA unwinding involved in DNA replication (GO:0006268)3.74121665
50protein complex disassembly (GO:0043241)3.69647193
51neutrophil activation (GO:0042119)3.59879814
52ribosomal large subunit biogenesis (GO:0042273)3.59836969
53CENP-A containing nucleosome assembly (GO:0034080)3.55368895
54pseudouridine synthesis (GO:0001522)3.53223267
55granulocyte differentiation (GO:0030851)3.50455557
56ribonucleoprotein complex biogenesis (GO:0022613)3.48170764
57macromolecular complex disassembly (GO:0032984)3.45760269
58G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.44312875
59nuclear-transcribed mRNA catabolic process (GO:0000956)3.44282353
60mitotic recombination (GO:0006312)3.43365339
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.43322868
62DNA replication checkpoint (GO:0000076)3.43104468
63lipoxygenase pathway (GO:0019372)3.41115589
64kinetochore organization (GO:0051383)3.38776706
65organelle membrane fusion (GO:0090174)3.36287562
66megakaryocyte development (GO:0035855)3.35886154
67formation of translation preinitiation complex (GO:0001731)3.34064807
68translation (GO:0006412)3.32662783
69chromatin remodeling at centromere (GO:0031055)3.31684793
70regulation of megakaryocyte differentiation (GO:0045652)3.30049673
71mRNA catabolic process (GO:0006402)3.28352412
72leukocyte migration involved in inflammatory response (GO:0002523)3.28082532
73leukocyte degranulation (GO:0043299)3.27898286
74fusion of sperm to egg plasma membrane (GO:0007342)3.27706161
75telomere maintenance via telomere lengthening (GO:0010833)3.27279387
76kinetochore assembly (GO:0051382)3.26320382
77erythrocyte differentiation (GO:0030218)3.25951375
78regulation of integrin-mediated signaling pathway (GO:2001044)3.23330805
79one-carbon compound transport (GO:0019755)3.22719821
80metallo-sulfur cluster assembly (GO:0031163)3.21841238
81iron-sulfur cluster assembly (GO:0016226)3.21841238
82RNA catabolic process (GO:0006401)3.19708323
83mitochondrial calcium ion transport (GO:0006851)3.18070794
84negative regulation of erythrocyte differentiation (GO:0045647)3.16297205
85regulation of mast cell activation (GO:0033003)3.16125582
86hemoglobin metabolic process (GO:0020027)3.15378243
87myeloid cell development (GO:0061515)3.14701376
88* regulation of erythrocyte differentiation (GO:0045646)3.14294793
89purine-containing compound salvage (GO:0043101)3.14066342
90negative regulation of norepinephrine secretion (GO:0010700)3.12636112
91DNA replication-independent nucleosome organization (GO:0034724)3.11839726
92DNA replication-independent nucleosome assembly (GO:0006336)3.11839726
93granulocyte activation (GO:0036230)3.08592439
94adenosine receptor signaling pathway (GO:0001973)3.07291456
95negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.07237312
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.06906047
97negative regulation of heart rate (GO:0010459)3.04609870
98IMP biosynthetic process (GO:0006188)3.04556759
99purinergic receptor signaling pathway (GO:0035587)3.04014359
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03655347
101negative regulation of thymocyte apoptotic process (GO:0070244)3.03169607
102rRNA processing (GO:0006364)3.02666174
103platelet dense granule organization (GO:0060155)3.02425411
104Arp2/3 complex-mediated actin nucleation (GO:0034314)3.01952653
105protein targeting to membrane (GO:0006612)3.01406751
106regulation of memory T cell differentiation (GO:0043380)3.00911570
107regulation of female receptivity (GO:0045924)2.99682702
108folic acid-containing compound biosynthetic process (GO:0009396)2.98953578
109homotypic cell-cell adhesion (GO:0034109)2.98914446
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98595088
111IMP metabolic process (GO:0046040)2.97843842
112regulation of integrin activation (GO:0033623)2.94810342
113rRNA metabolic process (GO:0016072)2.93124699
114ribosome biogenesis (GO:0042254)2.91692147
115positive regulation of endothelial cell differentiation (GO:0045603)2.88811036
116regulation of lipoprotein metabolic process (GO:0050746)2.88230217
117negative regulation of RNA splicing (GO:0033119)2.88171667
118deoxyribose phosphate biosynthetic process (GO:0046385)2.87992996
1192-deoxyribonucleotide biosynthetic process (GO:0009265)2.87992996
120positive regulation of cAMP-mediated signaling (GO:0043950)2.86705061
121positive regulation of erythrocyte differentiation (GO:0045648)2.85529070
122cellular component biogenesis (GO:0044085)2.84160353
123negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.83440724
124endothelium development (GO:0003158)2.81948025
125protein localization to chromosome, centromeric region (GO:0071459)2.81775082
126daunorubicin metabolic process (GO:0044597)2.80604352
127polyketide metabolic process (GO:0030638)2.80604352
128doxorubicin metabolic process (GO:0044598)2.80604352
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78807408
130response to interferon-beta (GO:0035456)2.78279752
131regulation of Golgi to plasma membrane protein transport (GO:0042996)2.78265910
132microtubule depolymerization (GO:0007019)2.78189704
133negative regulation of appetite (GO:0032099)2.78047063
134negative regulation of response to food (GO:0032096)2.78047063
135regulation of MHC class II biosynthetic process (GO:0045346)2.77986856
136positive regulation of megakaryocyte differentiation (GO:0045654)2.77307704
137regulation of mast cell activation involved in immune response (GO:0033006)2.76482431
138monoamine transport (GO:0015844)2.76446036
139pigment biosynthetic process (GO:0046148)2.75862509
140regulation of mast cell degranulation (GO:0043304)2.75342411
141negative regulation of platelet activation (GO:0010544)2.75144803
142triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.73439331
143tRNA methylation (GO:0030488)2.73007158
144positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.72759842
145pyrimidine nucleotide catabolic process (GO:0006244)2.72531189
146pteridine-containing compound biosynthetic process (GO:0042559)2.71726787
147negative regulation of T-helper cell differentiation (GO:0045623)2.71607236
148negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71607236
149histone mRNA metabolic process (GO:0008334)2.71255698
150oxidative phosphorylation (GO:0006119)2.71011848
151protein localization to kinetochore (GO:0034501)2.69852274
152deoxyribonucleotide biosynthetic process (GO:0009263)2.69718161
153cellular response to thyroid hormone stimulus (GO:0097067)2.68632737
154positive regulation of B cell differentiation (GO:0045579)2.65914059
155negative regulation of calcium ion transport into cytosol (GO:0010523)2.65326379
156spliceosomal snRNP assembly (GO:0000387)2.65062731
157cardiolipin metabolic process (GO:0032048)2.64175693
158negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.63701690
159pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61799734
160regulation of inositol phosphate biosynthetic process (GO:0010919)2.61792449
161negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61618677
162positive regulation of gamma-delta T cell activation (GO:0046645)2.61370159
163female mating behavior (GO:0060180)2.60324283
164translesion synthesis (GO:0019985)2.60262638
165rRNA modification (GO:0000154)2.59918026
166tetrapyrrole metabolic process (GO:0033013)2.58695130
167polyamine biosynthetic process (GO:0006596)2.57536967
168dopamine transport (GO:0015872)2.56239064
169actin nucleation (GO:0045010)2.55050670
170mast cell degranulation (GO:0043303)2.53657800
171mast cell activation involved in immune response (GO:0002279)2.53657800
172negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.51396329
173cellular biogenic amine catabolic process (GO:0042402)2.47862696
174amine catabolic process (GO:0009310)2.47862696
175positive regulation of macrophage differentiation (GO:0045651)2.47413714
176mast cell activation (GO:0045576)2.46752719
177positive regulation of mast cell activation involved in immune response (GO:0033008)2.46489023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.29522697
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.66552334
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.75255231
4* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.62393927
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96454574
6* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.94742758
7* SCL_19346495_ChIP-Seq_HPC-7_Human2.93040050
8* GATA2_19941826_ChIP-Seq_K562_Human2.83552810
9* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.73007713
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64111059
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.63948028
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60573767
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.60440973
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.57950010
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57891522
16TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.56945155
17GATA1_22025678_ChIP-Seq_K562_Human2.55017472
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52726783
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49729387
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49202149
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.47556996
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40565399
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28802964
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.26798251
25VDR_23849224_ChIP-Seq_CD4+_Human2.23706057
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22024334
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18239262
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17625805
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15560025
30* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10098198
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08731712
32XRN2_22483619_ChIP-Seq_HELA_Human2.02994806
33FOXP3_21729870_ChIP-Seq_TREG_Human2.00788527
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00435032
35* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97209122
36* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.95187387
37SPI1_23127762_ChIP-Seq_K562_Human1.94547013
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94242728
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94040781
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.92246220
41MYC_22102868_ChIP-Seq_BL_Human1.92186137
42* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.91475238
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.80705839
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79408824
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77845179
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76988157
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76984486
48DCP1A_22483619_ChIP-Seq_HELA_Human1.76836102
49* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74885587
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74205499
51GABP_19822575_ChIP-Seq_HepG2_Human1.73859273
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73203809
53* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71465669
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.70464911
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69793037
56VDR_22108803_ChIP-Seq_LS180_Human1.68933305
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.68929769
58VDR_21846776_ChIP-Seq_THP-1_Human1.66867685
59CIITA_25753668_ChIP-Seq_RAJI_Human1.65391446
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64573160
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60676058
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.59249542
63TTF2_22483619_ChIP-Seq_HELA_Human1.59014298
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57220200
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.55560355
66IRF1_19129219_ChIP-ChIP_H3396_Human1.54984485
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50325855
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48453844
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48433002
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.46906956
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44956389
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44616159
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44369455
74ELK1_19687146_ChIP-ChIP_HELA_Human1.44002093
75AR_21909140_ChIP-Seq_LNCAP_Human1.43846953
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43393490
77SPI1_23547873_ChIP-Seq_NB4_Human1.42211702
78NCOR1_26117541_ChIP-Seq_K562_Human1.36820321
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35343990
80RUNX_20019798_ChIP-Seq_JUKART_Human1.34564799
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34492613
82* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31332453
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30325370
84TP53_22573176_ChIP-Seq_HFKS_Human1.29320110
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29234636
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.28511211
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26621573
88GATA3_27048872_Chip-Seq_THYMUS_Human1.26352380
89IGF1R_20145208_ChIP-Seq_DFB_Human1.26351381
90* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26063632
91* GATA3_26560356_Chip-Seq_TH2_Human1.26010494
92ZNF274_21170338_ChIP-Seq_K562_Hela1.24803421
93SPI1_20517297_ChIP-Seq_HL60_Human1.22451661
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.21994717
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.21879067
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21729097
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.20185050
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19629873
99HTT_18923047_ChIP-ChIP_STHdh_Human1.19279088
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18510590
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.17902857
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15825788
103NANOG_20526341_ChIP-Seq_ESCs_Human1.15327694
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15268389
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15178443
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14910300
107STAT1_20625510_ChIP-Seq_HELA_Human1.14507662
108ETS1_22383799_ChIP-Seq_G1ME_Mouse1.13640425
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12947239
110KDM5A_27292631_Chip-Seq_BREAST_Human1.12611342
111GBX2_23144817_ChIP-Seq_PC3_Human1.12088564
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11155198
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10191465
114P300_27268052_Chip-Seq_Bcells_Human1.09124974
115* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08646824
116SALL4_22934838_ChIP-ChIP_CD34+_Human1.08388260
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08163688
118* GATA1_19941826_ChIP-Seq_K562_Human1.07967228
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06999388
120NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06646743
121ER_23166858_ChIP-Seq_MCF-7_Human1.06469060
122* BCL6_27268052_Chip-Seq_Bcells_Human1.05466013
123STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04184320
124GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04042318
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03898064
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03651488
127* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03010508
128ERG_20517297_ChIP-Seq_VCAP_Human1.02837362
129EGR1_19374776_ChIP-ChIP_THP-1_Human1.02533419
130FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02281106
131FOXA1_25329375_ChIP-Seq_VCAP_Human1.02281106
132ELF1_20517297_ChIP-Seq_JURKAT_Human1.01490763
133* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01112502
134PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98869146
135TFEB_21752829_ChIP-Seq_HELA_Human0.98393377
136* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98291168
137AR_20517297_ChIP-Seq_VCAP_Human0.97188664
138MAF_26560356_Chip-Seq_TH1_Human0.96401326
139CEBPB_22108803_ChIP-Seq_LS180_Human0.96020014
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94740625
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94206037
142EWS_26573619_Chip-Seq_HEK293_Human0.93811143
143VDR_24763502_ChIP-Seq_THP-1_Human0.93165563
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92833843
145SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92760914
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91446799
147YY1_22570637_ChIP-Seq_MALME-3M_Human0.91392677
148MYC_18940864_ChIP-ChIP_HL60_Human0.91253563
149MYB_26560356_Chip-Seq_TH1_Human0.89696970
150UTX_26944678_Chip-Seq_JUKART_Human0.89209034
151FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89056149
152MYB_26560356_Chip-Seq_TH2_Human0.88946764
153ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88769698
154GATA3_26560356_Chip-Seq_TH1_Human0.88124972
155STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87450364
156* BCOR_27268052_Chip-Seq_Bcells_Human0.86980077
157* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86967332
158FLI1_27457419_Chip-Seq_LIVER_Mouse0.86941809
159SMRT_27268052_Chip-Seq_Bcells_Human0.85532422
160FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84579986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.27025269
2MP0004147_increased_porphyrin_level6.19954221
3MP0002396_abnormal_hematopoietic_system3.91593094
4MP0001545_abnormal_hematopoietic_system3.88084080
5MP0005397_hematopoietic_system_phenotyp3.88084080
6MP0006054_spinal_hemorrhage3.59889731
7MP0003111_abnormal_nucleus_morphology3.09209084
8MP0008004_abnormal_stomach_pH3.08587228
9MP0003693_abnormal_embryo_hatching2.99442912
10MP0010094_abnormal_chromosome_stability2.96493739
11MP0004957_abnormal_blastocyst_morpholog2.60643246
12MP0008057_abnormal_DNA_replication2.54516029
13MP0000490_abnormal_crypts_of2.48193007
14MP0003077_abnormal_cell_cycle2.47332148
15MP0005075_abnormal_melanosome_morpholog2.37777901
16MP0004808_abnormal_hematopoietic_stem2.34617982
17MP0002132_abnormal_respiratory_system2.34107058
18MP0008058_abnormal_DNA_repair2.26476118
19MP0005464_abnormal_platelet_physiology2.10156106
20MP0005410_abnormal_fertilization2.07208524
21* MP0002398_abnormal_bone_marrow2.00531690
22MP0005646_abnormal_pituitary_gland1.98537213
23MP0008007_abnormal_cellular_replicative1.88669210
24MP0006036_abnormal_mitochondrial_physio1.88041373
25MP0005084_abnormal_gallbladder_morpholo1.84359349
26MP0003303_peritoneal_inflammation1.78887927
27MP0000689_abnormal_spleen_morphology1.77953802
28MP0002722_abnormal_immune_system1.76911412
29MP0005174_abnormal_tail_pigmentation1.74408704
30MP0000465_gastrointestinal_hemorrhage1.73770463
31MP0003186_abnormal_redox_activity1.69027670
32MP0001835_abnormal_antigen_presentation1.68477281
33MP0000685_abnormal_immune_system1.68336136
34MP0009333_abnormal_splenocyte_physiolog1.67745884
35MP0003806_abnormal_nucleotide_metabolis1.65542242
36MP0002736_abnormal_nociception_after1.64778562
37MP0005671_abnormal_response_to1.64685027
38MP0009379_abnormal_foot_pigmentation1.59570185
39MP0003724_increased_susceptibility_to1.58394127
40MP0000230_abnormal_systemic_arterial1.58249583
41MP0003763_abnormal_thymus_physiology1.55936199
42* MP0002429_abnormal_blood_cell1.53512952
43MP0001968_abnormal_touch/_nociception1.47285433
44MP0008877_abnormal_DNA_methylation1.42419214
45MP0002095_abnormal_skin_pigmentation1.40994466
46MP0003718_maternal_effect1.37474479
47MP0000313_abnormal_cell_death1.36124091
48MP0000372_irregular_coat_pigmentation1.31166125
49MP0000716_abnormal_immune_system1.30150936
50MP0003786_premature_aging1.30113745
51MP0002019_abnormal_tumor_incidence1.27793505
52MP0005636_abnormal_mineral_homeostasis1.27416016
53MP0001853_heart_inflammation1.26199465
54MP0000703_abnormal_thymus_morphology1.23502405
55MP0003638_abnormal_response/metabolism_1.21557896
56MP0009785_altered_susceptibility_to1.20584009
57MP0002733_abnormal_thermal_nociception1.17275978
58MP0005025_abnormal_response_to1.15805090
59MP0008995_early_reproductive_senescence1.15796161
60MP0001800_abnormal_humoral_immune1.15359446
61MP0002420_abnormal_adaptive_immunity1.14077355
62MP0006276_abnormal_autonomic_nervous1.12746778
63MP0005167_abnormal_blood-brain_barrier1.12221497
64MP0006292_abnormal_olfactory_placode1.12202635
65MP0004084_abnormal_cardiac_muscle1.12183703
66MP0001819_abnormal_immune_cell1.11312785
67MP0003866_abnormal_defecation1.10105311
68MP0002723_abnormal_immune_serum1.09733321
69MP0000350_abnormal_cell_proliferation1.07910974
70MP0008932_abnormal_embryonic_tissue1.07731003
71MP0004510_myositis1.07218216
72MP0002452_abnormal_antigen_presenting1.05382515
73MP0009765_abnormal_xenobiotic_induced1.05135132
74MP0009763_increased_sensitivity_to1.03705426
75MP0006035_abnormal_mitochondrial_morpho1.02813534
76MP0001873_stomach_inflammation1.01368247
77MP0002166_altered_tumor_susceptibility1.01071143
78MP0010352_gastrointestinal_tract_polyps1.00734359
79MP0005645_abnormal_hypothalamus_physiol0.99454824
80MP0010155_abnormal_intestine_physiology0.98112951
81MP0005000_abnormal_immune_tolerance0.97305644
82MP0009278_abnormal_bone_marrow0.96043276
83MP0005535_abnormal_body_temperature0.94944067
84MP0001851_eye_inflammation0.92974274
85MP0008469_abnormal_protein_level0.92396893
86MP0008872_abnormal_physiological_respon0.91799963
87MP0004142_abnormal_muscle_tone0.90676793
88MP0002102_abnormal_ear_morphology0.90458340
89MP0003787_abnormal_imprinting0.89609206
90MP0003436_decreased_susceptibility_to0.88978283
91MP0010307_abnormal_tumor_latency0.86951275
92MP0001764_abnormal_homeostasis0.85781153
93MP0002405_respiratory_system_inflammati0.84512588
94MP0009642_abnormal_blood_homeostasis0.83750598
95MP0003943_abnormal_hepatobiliary_system0.82585261
96MP0010329_abnormal_lipoprotein_level0.81745963
97* MP0002080_prenatal_lethality0.81729087
98MP0004215_abnormal_myocardial_fiber0.80413594
99MP0002419_abnormal_innate_immunity0.78767420
100MP0004130_abnormal_muscle_cell0.78389848
101MP0003698_abnormal_male_reproductive0.76919339
102MP0003567_abnormal_fetal_cardiomyocyte0.76024911
103MP0001970_abnormal_pain_threshold0.75731449
104MP0009764_decreased_sensitivity_to0.75577533
105MP0002877_abnormal_melanocyte_morpholog0.74741223
106MP0000598_abnormal_liver_morphology0.74323903
107MP0008775_abnormal_heart_ventricle0.73909906
108MP0002735_abnormal_chemical_nociception0.73716581
109MP0000358_abnormal_cell_content/0.73667945
110MP0004036_abnormal_muscle_relaxation0.73097577
111MP0001664_abnormal_digestion0.72666936
112MP0001730_embryonic_growth_arrest0.72108878
113MP0002148_abnormal_hypersensitivity_rea0.71422361
114MP0001533_abnormal_skeleton_physiology0.71026940
115MP0000858_altered_metastatic_potential0.70692480
116MP0005551_abnormal_eye_electrophysiolog0.69619427
117MP0002006_tumorigenesis0.69453235
118MP0001845_abnormal_inflammatory_respons0.69417598
119MP0003172_abnormal_lysosome_physiology0.69058664
120MP0001929_abnormal_gametogenesis0.67893085
121MP0005083_abnormal_biliary_tract0.67240212
122MP0001986_abnormal_taste_sensitivity0.66965016
123MP0008770_decreased_survivor_rate0.66021297
124MP0000249_abnormal_blood_vessel0.65181240
125* MP0009931_abnormal_skin_appearance0.64756110
126MP0001915_intracranial_hemorrhage0.64405450
127MP0008875_abnormal_xenobiotic_pharmacok0.63874183
128MP0000477_abnormal_intestine_morphology0.63160611
129MP0005670_abnormal_white_adipose0.63144274
130MP0009697_abnormal_copulation0.61192986
131MP0005387_immune_system_phenotype0.61035350
132MP0001790_abnormal_immune_system0.61035350
133MP0001697_abnormal_embryo_size0.60908835
134MP0000343_altered_response_to0.59514839
135MP0005319_abnormal_enzyme/_coenzyme0.59232794
136MP0000015_abnormal_ear_pigmentation0.56663995
137MP0001663_abnormal_digestive_system0.56352236
138MP0003011_delayed_dark_adaptation0.56136519
139MP0002075_abnormal_coat/hair_pigmentati0.55123807
140MP0005584_abnormal_enzyme/coenzyme_acti0.54914309

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)8.22891507
2Increased mean platelet volume (HP:0011877)8.19174246
3Abnormality of cells of the erythroid lineage (HP:0012130)7.91463979
4Menorrhagia (HP:0000132)7.63954056
5Poikilocytosis (HP:0004447)5.55303248
6Petechiae (HP:0000967)5.30391405
7Acanthocytosis (HP:0001927)5.09666217
8Aplastic anemia (HP:0001915)5.04310731
9Pallor (HP:0000980)4.55148055
10Reticulocytosis (HP:0001923)4.27405639
11Abnormality of reticulocytes (HP:0004312)4.26397405
12Reticulocytopenia (HP:0001896)4.24604988
13Birth length less than 3rd percentile (HP:0003561)3.75594520
14* Prolonged bleeding time (HP:0003010)3.56033517
15Macrocytic anemia (HP:0001972)3.55396908
16Increased serum ferritin (HP:0003281)3.43711926
17Hyperthyroidism (HP:0000836)3.33680562
18Hyperbilirubinemia (HP:0002904)3.28416899
19Thrombocytosis (HP:0001894)3.23388874
20Hyperlipoproteinemia (HP:0010980)3.21885280
21Short middle phalanx of the 5th finger (HP:0004220)3.17315127
22Stomatitis (HP:0010280)3.17143936
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01215109
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01215109
25Microcytic anemia (HP:0001935)2.97476846
26IgM deficiency (HP:0002850)2.86963170
27Abnormality of iron homeostasis (HP:0011031)2.86622572
283-Methylglutaconic aciduria (HP:0003535)2.86607679
29Reduced antithrombin III activity (HP:0001976)2.84905939
30* Epistaxis (HP:0000421)2.84238805
31Abnormal platelet function (HP:0011869)2.79868947
32Impaired platelet aggregation (HP:0003540)2.79868947
33Chronic otitis media (HP:0000389)2.78502077
34Spontaneous hematomas (HP:0007420)2.77316019
35Type I transferrin isoform profile (HP:0003642)2.71746420
36Polycythemia (HP:0001901)2.69115034
37Abnormal pupillary function (HP:0007686)2.60088473
38Abnormal hemoglobin (HP:0011902)2.57556385
39Oral leukoplakia (HP:0002745)2.56187803
40Abnormality of transition element cation homeostasis (HP:0011030)2.54309400
41Dyschromatopsia (HP:0007641)2.51615888
42Chronic obstructive pulmonary disease (HP:0006510)2.48212669
43Obstructive lung disease (HP:0006536)2.48212669
44Tinnitus (HP:0000360)2.44608444
45Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44196888
46Decreased central vision (HP:0007663)2.40754926
47Cutaneous photosensitivity (HP:0000992)2.38568332
48Pancytopenia (HP:0001876)2.37313211
49Microretrognathia (HP:0000308)2.31746307
50* Bruising susceptibility (HP:0000978)2.28914939
51* Myelodysplasia (HP:0002863)2.28828807
52Purpura (HP:0000979)2.28072435
53Microvesicular hepatic steatosis (HP:0001414)2.27836295
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24992671
55Abnormal protein N-linked glycosylation (HP:0012347)2.24992671
56Abnormal protein glycosylation (HP:0012346)2.24992671
57Abnormal glycosylation (HP:0012345)2.24992671
58Increased serum lactate (HP:0002151)2.23879985
59Hepatocellular necrosis (HP:0001404)2.23754459
60Abnormality of lateral ventricle (HP:0030047)2.23063126
61Attenuation of retinal blood vessels (HP:0007843)2.21844507
62Hypertensive crisis (HP:0100735)2.20875820
63Broad palm (HP:0001169)2.19320441
6411 pairs of ribs (HP:0000878)2.17959618
65Hypochromic anemia (HP:0001931)2.16358990
66Encephalitis (HP:0002383)2.11915737
67Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.11628088
68Diaphragmatic weakness (HP:0009113)2.07977997
69Elevated erythrocyte sedimentation rate (HP:0003565)2.07635722
70Abnormality of T cell physiology (HP:0011840)2.05400190
71Amaurosis fugax (HP:0100576)2.04653759
72Acute lymphatic leukemia (HP:0006721)2.02787655
73Increased intramyocellular lipid droplets (HP:0012240)2.02737306
74Hepatic necrosis (HP:0002605)2.01249443
75Exertional dyspnea (HP:0002875)2.00157334
76Abnormality of the heme biosynthetic pathway (HP:0010472)11.5932058
77Generalized aminoaciduria (HP:0002909)1.99616695
78Chromsome breakage (HP:0040012)1.99380519
79Abnormality of the prostate (HP:0008775)1.95154151
80Cerebral palsy (HP:0100021)1.94459607
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94117947
82Bone marrow hypocellularity (HP:0005528)1.93893404
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91714661
84Seborrheic dermatitis (HP:0001051)1.91696025
85Muscle fiber atrophy (HP:0100295)1.91358144
86Increased IgM level (HP:0003496)1.90566956
87Increased hepatocellular lipid droplets (HP:0006565)1.90396239
88Mitochondrial inheritance (HP:0001427)1.89647648
89Autoimmune hemolytic anemia (HP:0001890)1.89344998
90Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.88441702
91Basal cell carcinoma (HP:0002671)1.88357683
92Recurrent viral infections (HP:0004429)1.87775493
93Truncus arteriosus (HP:0001660)1.85573180
94Migraine (HP:0002076)1.84774539
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84563846
96Abnormality of alanine metabolism (HP:0010916)1.84563846
97Hyperalaninemia (HP:0003348)1.84563846
98Arterial thrombosis (HP:0004420)1.84118224
99Brushfield spots (HP:0001088)1.83959571
100Spontaneous abortion (HP:0005268)1.83771376
101Lymphoma (HP:0002665)1.83642826
102Paralysis (HP:0003470)1.83187002
103Increased muscle lipid content (HP:0009058)1.83075838
104Type 2 muscle fiber atrophy (HP:0003554)1.83005989
105Renal Fanconi syndrome (HP:0001994)1.82556587
106Ileus (HP:0002595)1.82548729
107Hepatosplenomegaly (HP:0001433)1.82291921
108Poor head control (HP:0002421)1.81319751
109Lipid accumulation in hepatocytes (HP:0006561)1.81313655
110Pendular nystagmus (HP:0012043)1.80838422
111Increased CSF lactate (HP:0002490)1.80501426
112Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80253924
113Ventricular fibrillation (HP:0001663)1.80249873
114Progressive muscle weakness (HP:0003323)1.79534124
115Cholelithiasis (HP:0001081)1.79268725
116Episodic fever (HP:0001954)1.79133854
117Neutropenia (HP:0001875)1.78984953
118Abnormal spermatogenesis (HP:0008669)1.76801213
119Abnormality of dental color (HP:0011073)1.76658519
120Nausea (HP:0002018)1.74060376
121Increased density of long bones (HP:0006392)1.73992928
122Abnormal rod and cone electroretinograms (HP:0008323)1.73894206
123Small intestinal stenosis (HP:0012848)1.73145861
124Duodenal stenosis (HP:0100867)1.73145861
125Absent/shortened dynein arms (HP:0200106)1.73138341
126Dynein arm defect of respiratory motile cilia (HP:0012255)1.73138341
127Abnormality of the nasal mucosa (HP:0000433)1.72528363
128Leukocytosis (HP:0001974)1.72358969
129Absent thumb (HP:0009777)1.71821328
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71622077
131Vertigo (HP:0002321)1.70786668
132Severe visual impairment (HP:0001141)1.70752689
133Cellulitis (HP:0100658)1.70507330
134Insomnia (HP:0100785)1.70283352
135Lactic acidosis (HP:0003128)1.70041253
136Abolished electroretinogram (ERG) (HP:0000550)1.70000058
137Congenital stationary night blindness (HP:0007642)1.69815416
138Hypochromic microcytic anemia (HP:0004840)1.69750364
139Respiratory difficulties (HP:0002880)1.68959660
140Panhypogammaglobulinemia (HP:0003139)1.68771829
141Conjunctival telangiectasia (HP:0000524)1.67664256
142Abnormal platelet volume (HP:0011876)1.66414140
143Abnormality of chromosome stability (HP:0003220)1.65885171
144Gingival bleeding (HP:0000225)1.64893935
145Hypoplastic iliac wings (HP:0002866)1.62728336
146Chest pain (HP:0100749)1.62461552
147Abnormality of the common coagulation pathway (HP:0010990)1.58803429
148Abnormality of the vasculature of the conjunctiva (HP:0008054)1.57203496
149Joint swelling (HP:0001386)1.56801916
150Acute encephalopathy (HP:0006846)1.55623128
151Upper limb muscle weakness (HP:0003484)1.52129251
152Abnormal gallbladder morphology (HP:0012437)1.50017409
153Thrombophlebitis (HP:0004418)1.49235688
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.48242401
155Myositis (HP:0100614)1.45096818
156Granulocytopenia (HP:0001913)1.44454587
157Thyroid-stimulating hormone excess (HP:0002925)1.42827437
158Renal cortical cysts (HP:0000803)1.42763670
159Recurrent fungal infections (HP:0002841)1.42691895
160Hypoparathyroidism (HP:0000829)1.41564139
161Cholecystitis (HP:0001082)1.39852236
162Abnormal gallbladder physiology (HP:0012438)1.39852236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.87931900
2NME23.47193106
3EIF2AK13.18980180
4STK163.08075614
5WEE12.97523927
6MST42.91599987
7CDC72.79286295
8BMX2.71236059
9NUAK12.48235973
10VRK12.46955666
11DYRK32.32207952
12PIM22.30847681
13BUB12.16905369
14BRSK22.13440293
15CDK192.05104458
16MAP4K12.04547394
17ACVR1B2.02239919
18FRK1.98182164
19EEF2K1.96142833
20MAP4K21.93462622
21KIT1.82440185
22PTK2B1.80592347
23MAPKAPK51.77410170
24RPS6KB21.75830346
25TGFBR11.68615350
26SCYL21.62837717
27FES1.59777310
28SRPK11.59745642
29MYLK1.52402523
30NEK21.51576598
31BTK1.49792187
32TNIK1.49382739
33MATK1.45458740
34MAP2K31.42400848
35KDR1.39678019
36GRK51.37713100
37CDK71.36533813
38MUSK1.35248845
39TLK11.33146219
40TEC1.32721989
41BMPR21.32169751
42BRSK11.31906992
43PIM11.31135614
44RPS6KA41.28670599
45ATR1.28200901
46MKNK11.25911064
47ITK1.25844638
48VRK21.23488618
49PIK3CG1.22508879
50CCNB11.20623637
51JAK31.19721388
52CDK81.18336964
53TGFBR21.13812856
54DAPK21.11835956
55IKBKE1.11715507
56HCK1.11182571
57MAP3K111.11122781
58MAPK131.10991626
59TBK11.10768143
60STK41.09418009
61AURKB1.08246572
62STK31.07889792
63PINK11.06101669
64IKBKB1.05957177
65STK101.02282423
66PLK11.01871659
67BMPR1B1.01690093
68MAPKAPK31.01294158
69SYK1.00469157
70LRRK21.00150904
71MARK30.97118474
72FLT30.96170334
73MAP3K100.96119632
74CDK40.95967189
75INSRR0.94487967
76PASK0.91631619
77ADRBK10.88221378
78TAOK30.87212517
79TESK20.86822284
80TTK0.83285319
81EIF2AK30.83151014
82CSF1R0.82234835
83TNK20.80810516
84TYK20.80312327
85LYN0.79678345
86TIE10.79407828
87MAPK110.78798945
88IRAK10.77153831
89TRPM70.75267069
90PRKCQ0.73868931
91TAOK20.73378110
92TSSK60.73172986
93GRK60.73084662
94DAPK10.71783329
95PLK20.71667809
96MAP3K60.71078290
97ZAP700.70959284
98FGR0.68898108
99CHEK20.68196140
100MAP3K80.68174179
101LCK0.64933249
102AURKA0.63364199
103JAK20.63278899
104DYRK20.63084253
105BLK0.62841041
106MAP3K50.62250423
107RPS6KA50.62078556
108RPS6KA60.61905492
109PKN10.61851202
110TAOK10.61196982
111BCKDK0.60436537
112PRKG20.59975732
113ADRBK20.59181819
114NEK10.59081989
115DAPK30.58999125
116RAF10.58234709
117CSNK2A20.57436728
118TXK0.55221243
119PAK10.54832236
120PDK10.53785202
121GRK10.53467834
122PRKACG0.51583512
123CHEK10.51547294
124CSNK2A10.51281146
125MAP3K120.51236939
126HIPK20.51002828
127RPS6KL10.50991502
128RPS6KC10.50991502
129ATM0.50901148
130MKNK20.50712637
131MAPK40.50135489
132ILK0.49913636
133MAP2K10.49052827
134EIF2AK20.48495365
135ZAK0.48339145
136PLK40.47061222
137PAK40.45367743
138CLK10.43179638
139MAP2K60.38218396
140NME10.36575020
141WNK30.36535890
142MAPK120.35925872
143TRIM280.33824457
144PRKCA0.33709566
145PRKCD0.33072785
146PDPK10.30364401
147MAPK30.29342842
148PRKACA0.27634012
149FER0.27472890
150PLK30.27144517
151ABL10.27109140
152PRKG10.27022666
153PRKCB0.26660520
154OXSR10.23568825

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.31508800
2Ribosome_Homo sapiens_hsa030105.12556202
3Mismatch repair_Homo sapiens_hsa034303.73933326
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.32607603
5Nitrogen metabolism_Homo sapiens_hsa009103.11297179
6Base excision repair_Homo sapiens_hsa034102.86034296
7Homologous recombination_Homo sapiens_hsa034402.74128403
8RNA polymerase_Homo sapiens_hsa030202.71730269
9Spliceosome_Homo sapiens_hsa030402.70051870
10Pyrimidine metabolism_Homo sapiens_hsa002402.67847721
11Nucleotide excision repair_Homo sapiens_hsa034202.59012945
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56009166
13Proteasome_Homo sapiens_hsa030502.35376747
14Cell cycle_Homo sapiens_hsa041102.05219947
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00796299
16RNA transport_Homo sapiens_hsa030131.94711521
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84237213
18One carbon pool by folate_Homo sapiens_hsa006701.81176795
19Sulfur relay system_Homo sapiens_hsa041221.80574201
20Fanconi anemia pathway_Homo sapiens_hsa034601.76377672
21RNA degradation_Homo sapiens_hsa030181.76180572
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75602822
23Olfactory transduction_Homo sapiens_hsa047401.73386547
24Linoleic acid metabolism_Homo sapiens_hsa005911.67389982
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64741918
26Non-homologous end-joining_Homo sapiens_hsa034501.59103491
27Collecting duct acid secretion_Homo sapiens_hsa049661.54883301
28Phototransduction_Homo sapiens_hsa047441.54356658
29Folate biosynthesis_Homo sapiens_hsa007901.51596255
30Basal transcription factors_Homo sapiens_hsa030221.49248109
31Purine metabolism_Homo sapiens_hsa002301.44735953
32Fatty acid elongation_Homo sapiens_hsa000621.41613810
33Systemic lupus erythematosus_Homo sapiens_hsa053221.40350829
34Allograft rejection_Homo sapiens_hsa053301.39599833
35p53 signaling pathway_Homo sapiens_hsa041151.33009812
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22428353
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21995439
38Herpes simplex infection_Homo sapiens_hsa051681.21940083
39Caffeine metabolism_Homo sapiens_hsa002321.20437831
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.20196457
41Graft-versus-host disease_Homo sapiens_hsa053321.19720121
42Parkinsons disease_Homo sapiens_hsa050121.19645621
43Hematopoietic cell lineage_Homo sapiens_hsa046401.18773958
44Protein export_Homo sapiens_hsa030601.17054792
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15423556
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10836063
47Pentose phosphate pathway_Homo sapiens_hsa000301.09983391
48Serotonergic synapse_Homo sapiens_hsa047261.07378490
49Autoimmune thyroid disease_Homo sapiens_hsa053201.05033935
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03075535
51Glycerolipid metabolism_Homo sapiens_hsa005611.03010748
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.01699237
53Type I diabetes mellitus_Homo sapiens_hsa049400.99980497
54Chemokine signaling pathway_Homo sapiens_hsa040620.96682409
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95817434
56Butanoate metabolism_Homo sapiens_hsa006500.93120139
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87489085
58Measles_Homo sapiens_hsa051620.86802414
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.86663270
60Regulation of autophagy_Homo sapiens_hsa041400.85802617
61Primary immunodeficiency_Homo sapiens_hsa053400.85161494
62ECM-receptor interaction_Homo sapiens_hsa045120.84338314
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.82023917
64African trypanosomiasis_Homo sapiens_hsa051430.81796538
65Huntingtons disease_Homo sapiens_hsa050160.81220844
66Sulfur metabolism_Homo sapiens_hsa009200.80463135
67mRNA surveillance pathway_Homo sapiens_hsa030150.79905584
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.78991654
69Propanoate metabolism_Homo sapiens_hsa006400.77355422
70Vitamin B6 metabolism_Homo sapiens_hsa007500.76943477
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75947619
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75909216
73N-Glycan biosynthesis_Homo sapiens_hsa005100.75755904
74Viral carcinogenesis_Homo sapiens_hsa052030.75642730
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73257967
76Selenocompound metabolism_Homo sapiens_hsa004500.73082202
77ABC transporters_Homo sapiens_hsa020100.71593552
78Epstein-Barr virus infection_Homo sapiens_hsa051690.70695783
79Antigen processing and presentation_Homo sapiens_hsa046120.70607369
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69568951
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68739143
82Acute myeloid leukemia_Homo sapiens_hsa052210.66624582
83Staphylococcus aureus infection_Homo sapiens_hsa051500.65449044
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.65014026
85Oxidative phosphorylation_Homo sapiens_hsa001900.63914540
86Leishmaniasis_Homo sapiens_hsa051400.62510191
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62045902
88Platelet activation_Homo sapiens_hsa046110.61129873
89Thyroid cancer_Homo sapiens_hsa052160.60938514
90Legionellosis_Homo sapiens_hsa051340.59760042
91Alcoholism_Homo sapiens_hsa050340.59712251
92Ether lipid metabolism_Homo sapiens_hsa005650.59530079
93Hepatitis B_Homo sapiens_hsa051610.56742256
94T cell receptor signaling pathway_Homo sapiens_hsa046600.56625552
95Apoptosis_Homo sapiens_hsa042100.55919558
96Pancreatic secretion_Homo sapiens_hsa049720.55537001
97B cell receptor signaling pathway_Homo sapiens_hsa046620.53841281
98Calcium signaling pathway_Homo sapiens_hsa040200.53628556
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.52702673
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52337201
101Rheumatoid arthritis_Homo sapiens_hsa053230.52223864
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51345344
103Other glycan degradation_Homo sapiens_hsa005110.49514989
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48552297
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47481310
106Chronic myeloid leukemia_Homo sapiens_hsa052200.46712590
107Chemical carcinogenesis_Homo sapiens_hsa052040.45820505
108Osteoclast differentiation_Homo sapiens_hsa043800.43852984
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43577767
110Fat digestion and absorption_Homo sapiens_hsa049750.43267979
111Small cell lung cancer_Homo sapiens_hsa052220.42778413
112Alzheimers disease_Homo sapiens_hsa050100.42522903
113Influenza A_Homo sapiens_hsa051640.42286813
114Metabolic pathways_Homo sapiens_hsa011000.42039443
115Glutathione metabolism_Homo sapiens_hsa004800.41701982
116Morphine addiction_Homo sapiens_hsa050320.41605114
117Long-term depression_Homo sapiens_hsa047300.41372699
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39924824
119Endocytosis_Homo sapiens_hsa041440.39899768
120Galactose metabolism_Homo sapiens_hsa000520.39659826
121Non-small cell lung cancer_Homo sapiens_hsa052230.39486955
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.38041789
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.36420649
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35861278
125HTLV-I infection_Homo sapiens_hsa051660.35698233
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.33691603
127Phagosome_Homo sapiens_hsa041450.33104640
128Malaria_Homo sapiens_hsa051440.32743770
129Biosynthesis of amino acids_Homo sapiens_hsa012300.32561542
130Shigellosis_Homo sapiens_hsa051310.32397084
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31028156
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28164299
133Arachidonic acid metabolism_Homo sapiens_hsa005900.26951926
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24770345
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22912635
136Carbon metabolism_Homo sapiens_hsa012000.20321599
137Toxoplasmosis_Homo sapiens_hsa051450.19536333
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19173583
139Oocyte meiosis_Homo sapiens_hsa041140.16901655
140Asthma_Homo sapiens_hsa053100.15182577
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11650114
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11633843
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10600463
144Pancreatic cancer_Homo sapiens_hsa052120.09818763
145Peroxisome_Homo sapiens_hsa041460.09714212
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.09268256

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