GFM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)6.22990109
2lysine catabolic process (GO:0006554)6.22990109
3tricarboxylic acid cycle (GO:0006099)5.48809366
4glyoxylate metabolic process (GO:0046487)5.22350722
52-oxoglutarate metabolic process (GO:0006103)5.09235177
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.05186390
7L-phenylalanine catabolic process (GO:0006559)5.05186390
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.04814550
9L-phenylalanine metabolic process (GO:0006558)5.04814550
10aspartate family amino acid catabolic process (GO:0009068)4.94928610
11kynurenine metabolic process (GO:0070189)4.83512740
12nuclear pore complex assembly (GO:0051292)4.74474130
13aromatic amino acid family catabolic process (GO:0009074)4.64855042
14amino-acid betaine metabolic process (GO:0006577)4.57048003
15serine family amino acid catabolic process (GO:0009071)4.56139050
16glycine metabolic process (GO:0006544)4.54663715
17carnitine shuttle (GO:0006853)4.54423774
18fatty acid transmembrane transport (GO:1902001)4.53963752
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.50152654
20ribosome assembly (GO:0042255)4.49480267
21nuclear pore organization (GO:0006999)4.48395252
22fatty acid beta-oxidation (GO:0006635)4.47814956
23acetyl-CoA metabolic process (GO:0006084)4.45102674
24cysteine metabolic process (GO:0006534)4.43618961
25alpha-linolenic acid metabolic process (GO:0036109)4.39192037
26cellular ketone body metabolic process (GO:0046950)4.37451683
27tryptophan catabolic process (GO:0006569)4.30362185
28indole-containing compound catabolic process (GO:0042436)4.30362185
29indolalkylamine catabolic process (GO:0046218)4.30362185
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.27074770
31oxaloacetate metabolic process (GO:0006107)4.21452957
32NADH metabolic process (GO:0006734)4.14056036
33carnitine metabolic process (GO:0009437)4.10399231
34branched-chain amino acid catabolic process (GO:0009083)4.09918362
35serine family amino acid metabolic process (GO:0009069)4.05977713
36bile acid biosynthetic process (GO:0006699)4.05407950
37tryptophan metabolic process (GO:0006568)4.04790813
38fatty acid oxidation (GO:0019395)4.04753457
39urea cycle (GO:0000050)4.02952653
40urea metabolic process (GO:0019627)4.02952653
41regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.02383219
42alpha-amino acid catabolic process (GO:1901606)4.02000040
43dicarboxylic acid biosynthetic process (GO:0043650)3.98211156
44valine metabolic process (GO:0006573)3.98065839
45lipid oxidation (GO:0034440)3.97331883
46serine family amino acid biosynthetic process (GO:0009070)3.95415999
47homocysteine metabolic process (GO:0050667)3.95112274
48fatty acid catabolic process (GO:0009062)3.90913328
49tricarboxylic acid metabolic process (GO:0072350)3.90622441
50short-chain fatty acid metabolic process (GO:0046459)3.87491097
51negative regulation of fatty acid biosynthetic process (GO:0045717)3.86593002
52ketone body metabolic process (GO:1902224)3.85963055
53branched-chain amino acid metabolic process (GO:0009081)3.83608652
54sulfur amino acid catabolic process (GO:0000098)3.81064987
55regulation of triglyceride catabolic process (GO:0010896)3.78835510
56cellular amino acid catabolic process (GO:0009063)3.75381923
57succinate metabolic process (GO:0006105)3.75301097
58complement activation, alternative pathway (GO:0006957)3.74538416
59monocarboxylic acid catabolic process (GO:0072329)3.69144015
60regulation of sequestering of triglyceride (GO:0010889)3.67428533
61nitrogen cycle metabolic process (GO:0071941)3.66688266
62pore complex assembly (GO:0046931)3.65578364
63regulation of protein activation cascade (GO:2000257)3.64243045
64mitochondrial RNA metabolic process (GO:0000959)3.63621116
65sarcomere organization (GO:0045214)3.62017773
66ethanol oxidation (GO:0006069)3.60614697
67carnitine transport (GO:0015879)3.55957385
68amino-acid betaine transport (GO:0015838)3.55957385
69regulation of acyl-CoA biosynthetic process (GO:0050812)3.55943311
70carnitine transmembrane transport (GO:1902603)3.55274450
71COPII vesicle coating (GO:0048208)3.53509773
72organic acid catabolic process (GO:0016054)3.53036054
73carboxylic acid catabolic process (GO:0046395)3.53036054
74biotin metabolic process (GO:0006768)3.52882906
75negative regulation of fibrinolysis (GO:0051918)3.52573489
76regulation of centriole replication (GO:0046599)3.49391445
77aromatic amino acid family metabolic process (GO:0009072)3.47065802
78cardiac myofibril assembly (GO:0055003)3.46808836
79glutamate metabolic process (GO:0006536)3.46578744
80regulation of fatty acid oxidation (GO:0046320)3.45194422
81fatty acid homeostasis (GO:0055089)3.45081427
82cellular modified amino acid catabolic process (GO:0042219)3.44841729
83regulation of complement activation (GO:0030449)3.44260654
84peptidyl-glutamic acid carboxylation (GO:0017187)3.44251985
85protein carboxylation (GO:0018214)3.44251985
86oxidative phosphorylation (GO:0006119)3.43547793
87regulation of cofactor metabolic process (GO:0051193)3.43361708
88regulation of coenzyme metabolic process (GO:0051196)3.43361708
89tRNA aminoacylation for protein translation (GO:0006418)3.42756014
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.42122054
91tRNA aminoacylation (GO:0043039)3.40210367
92amino acid activation (GO:0043038)3.40210367
93mitotic sister chromatid cohesion (GO:0007064)3.36979311
94bile acid metabolic process (GO:0008206)3.33195367
95high-density lipoprotein particle remodeling (GO:0034375)3.30600527
96dicarboxylic acid metabolic process (GO:0043648)3.28379725
97coenzyme catabolic process (GO:0009109)3.27401208
98triglyceride homeostasis (GO:0070328)3.26640604
99acylglycerol homeostasis (GO:0055090)3.26640604
100positive regulation of fatty acid oxidation (GO:0046321)3.22748150
101negative regulation of fatty acid metabolic process (GO:0045922)3.20622826
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19966697
103phospholipid homeostasis (GO:0055091)3.19344667
104actin-myosin filament sliding (GO:0033275)3.18384602
105muscle filament sliding (GO:0030049)3.18384602
106tyrosine metabolic process (GO:0006570)3.16487413
107DNA double-strand break processing (GO:0000729)3.15689043
108regulation of fatty acid beta-oxidation (GO:0031998)3.15037389
109regulation of translational fidelity (GO:0006450)3.14898690
110quaternary ammonium group transport (GO:0015697)3.13716118
111folic acid-containing compound biosynthetic process (GO:0009396)3.13681573
112regulation of fibrinolysis (GO:0051917)3.13134968
113imidazole-containing compound metabolic process (GO:0052803)3.12276999
114DNA strand elongation involved in DNA replication (GO:0006271)3.12192283
115NAD metabolic process (GO:0019674)3.11450405
116maturation of 5.8S rRNA (GO:0000460)3.09902949
117L-serine metabolic process (GO:0006563)3.09647960
118mitotic nuclear envelope disassembly (GO:0007077)3.09440975
119pseudouridine synthesis (GO:0001522)3.02630107
120DNA strand elongation (GO:0022616)3.00728431
121meiotic chromosome segregation (GO:0045132)2.99880684
122regulation of DNA endoreduplication (GO:0032875)2.99501983
123somatic hypermutation of immunoglobulin genes (GO:0016446)2.96734526
124somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96734526
125proteasome assembly (GO:0043248)2.95519766
126IMP biosynthetic process (GO:0006188)2.93920984
127ubiquinone biosynthetic process (GO:0006744)2.92463348
128ER overload response (GO:0006983)2.91758065
129DNA replication-dependent nucleosome assembly (GO:0006335)2.88024807
130DNA replication-dependent nucleosome organization (GO:0034723)2.88024807
131transcription from mitochondrial promoter (GO:0006390)2.87679965
132nucleobase biosynthetic process (GO:0046112)2.87400404
133double-strand break repair via nonhomologous end joining (GO:0006303)2.86123522
134non-recombinational repair (GO:0000726)2.86123522
135replication fork processing (GO:0031297)2.86119905
136nuclear envelope disassembly (GO:0051081)2.85939265
137membrane disassembly (GO:0030397)2.85939265
138IMP metabolic process (GO:0046040)2.84653309
139telomere maintenance via semi-conservative replication (GO:0032201)2.83792213
140aspartate family amino acid biosynthetic process (GO:0009067)2.83054526
141L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82940399
142postreplication repair (GO:0006301)2.82640607
143ribosome biogenesis (GO:0042254)2.82547041
144methionine biosynthetic process (GO:0009086)2.82374599
145regulation of centrosome cycle (GO:0046605)2.81415296
146folic acid metabolic process (GO:0046655)2.79689274
147regulation of centrosome duplication (GO:0010824)2.76877202
148purine nucleobase biosynthetic process (GO:0009113)2.76145001
149protein K6-linked ubiquitination (GO:0085020)2.72666114
150ubiquinone metabolic process (GO:0006743)2.72562252
151regulation of translational elongation (GO:0006448)2.71113866
152pteridine-containing compound biosynthetic process (GO:0042559)2.68804147
153tRNA methylation (GO:0030488)2.68034958
154tetrahydrofolate metabolic process (GO:0046653)2.67755133
155DNA geometric change (GO:0032392)2.66491913
156RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65028300
157DNA replication initiation (GO:0006270)2.64532874
158DNA duplex unwinding (GO:0032508)2.62198868
159protein deneddylation (GO:0000338)2.61998574
160cullin deneddylation (GO:0010388)2.61932052
161histone H2A acetylation (GO:0043968)2.61269963
162mitotic chromosome condensation (GO:0007076)2.60992626
163tRNA metabolic process (GO:0006399)2.58954953
164synapsis (GO:0007129)2.58062616
165sulfur amino acid biosynthetic process (GO:0000097)2.57838320
166DNA unwinding involved in DNA replication (GO:0006268)2.57360442
167formation of translation preinitiation complex (GO:0001731)2.55321410
168telomere maintenance via recombination (GO:0000722)2.53460266
169amino acid salvage (GO:0043102)2.52776183
170L-methionine salvage (GO:0071267)2.52776183
171L-methionine biosynthetic process (GO:0071265)2.52776183
172regulation of hexokinase activity (GO:1903299)2.51670677
173regulation of glucokinase activity (GO:0033131)2.51670677
174translesion synthesis (GO:0019985)2.51184174
175methionine metabolic process (GO:0006555)2.50993137
176folic acid-containing compound metabolic process (GO:0006760)2.50052866
177somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49609692
178somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49609692
179isotype switching (GO:0045190)2.49609692
180rRNA catabolic process (GO:0016075)2.49457276
181regulation of sister chromatid cohesion (GO:0007063)2.49338849
182DNA catabolic process, exonucleolytic (GO:0000738)2.48980974
183respiratory chain complex IV assembly (GO:0008535)2.48866430
184ribonucleoprotein complex disassembly (GO:0032988)2.47689021
185DNA replication checkpoint (GO:0000076)2.47265181
186mitotic sister chromatid segregation (GO:0000070)2.45957589
187mitochondrial DNA replication (GO:0006264)2.45409832
188regulation of relaxation of muscle (GO:1901077)2.44980075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.35490737
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.41921494
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.48296611
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.10252160
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.17671915
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.03741846
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.53720167
8E2F7_22180533_ChIP-Seq_HELA_Human3.51495067
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.39685841
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.14239613
11* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94104306
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.74294221
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.73608896
14IGF1R_20145208_ChIP-Seq_DFB_Human2.64119692
15* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.63944696
16* ELK1_19687146_ChIP-ChIP_HELA_Human2.58906223
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.26920958
18* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21192804
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.21102144
20AR_21909140_ChIP-Seq_LNCAP_Human2.15920867
21CLOCK_20551151_ChIP-Seq_293T_Human2.15149021
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10964652
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.10868008
24* VDR_23849224_ChIP-Seq_CD4+_Human2.08316925
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.94673325
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93150879
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83990756
28ZNF263_19887448_ChIP-Seq_K562_Human1.83480245
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77537558
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76246950
31* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71519202
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.66350544
33GATA1_22025678_ChIP-Seq_K562_Human1.62875588
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62074168
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58439104
36VDR_22108803_ChIP-Seq_LS180_Human1.52570449
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49495798
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45127680
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44390236
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42052369
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40466116
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.39823691
43TFEB_21752829_ChIP-Seq_HELA_Human1.37568689
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37426608
45MYC_18940864_ChIP-ChIP_HL60_Human1.36974291
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35926360
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.34206988
48* TTF2_22483619_ChIP-Seq_HELA_Human1.33922879
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33260872
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33240858
51FUS_26573619_Chip-Seq_HEK293_Human1.32847239
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32266292
53ZNF274_21170338_ChIP-Seq_K562_Hela1.32151742
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31918746
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31663989
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30808928
57EWS_26573619_Chip-Seq_HEK293_Human1.30521906
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29535653
59* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26966796
60GATA4_21415370_ChIP-Seq_HL-1_Mouse1.24259729
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19877242
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19000994
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18744480
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.18652534
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17796487
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15831806
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15500582
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15004658
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.14590461
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.14590461
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.12254910
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10263959
73* HNF4A_19822575_ChIP-Seq_HepG2_Human1.09278790
74* ETS1_20019798_ChIP-Seq_JURKAT_Human1.07772695
75NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07704300
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06088230
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06077862
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05704746
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05587445
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04037145
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02742616
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01890898
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01848195
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01122172
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01102721
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00686693
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98665630
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98495011
89MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97838409
90ER_23166858_ChIP-Seq_MCF-7_Human0.95987287
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95290064
92* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95137373
93ATF3_27146783_Chip-Seq_COLON_Human0.95030106
94FOXA2_19822575_ChIP-Seq_HepG2_Human0.95012388
95E2F1_21310950_ChIP-Seq_MCF-7_Human0.94659728
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94591478
97DCP1A_22483619_ChIP-Seq_HELA_Human0.94264735
98MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93077403
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92877434
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92809172
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92723928
102PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92291672
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.92170378
104ELF5_23300383_ChIP-Seq_T47D_Human0.89209061
105GABP_17652178_ChIP-ChIP_JURKAT_Human0.86069074
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85912291
107KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85872944
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84990670
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83354290
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82344688
111GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81656246
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81404783
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80699865
114XRN2_22483619_ChIP-Seq_HELA_Human0.79162841
115TAF15_26573619_Chip-Seq_HEK293_Human0.79096969
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78983689
117* GABP_19822575_ChIP-Seq_HepG2_Human0.78904593
118* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78426553
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.77391098
120FOXP3_21729870_ChIP-Seq_TREG_Human0.77258819
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76202204
122SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76193846
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.76071671
124KDM5A_27292631_Chip-Seq_BREAST_Human0.75985157
125TP53_22573176_ChIP-Seq_HFKS_Human0.75674098
126RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75617129
127CIITA_25753668_ChIP-Seq_RAJI_Human0.75476861
128GATA4_25053715_ChIP-Seq_YYC3_Human0.72678718
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72333999
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71769753
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71315756
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.70980749
133HTT_18923047_ChIP-ChIP_STHdh_Human0.70977215
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.69731771
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69638795
136PADI4_21655091_ChIP-ChIP_MCF-7_Human0.69078803
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.67535701
138GATA6_25053715_ChIP-Seq_YYC3_Human0.67406668
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.67125931
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66816060
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.66571084
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.66517096
143PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.65766186
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.64333575
145NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.64265471
146HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64041255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.49952387
2MP0002139_abnormal_hepatobiliary_system5.48971035
3MP0003806_abnormal_nucleotide_metabolis4.60847835
4MP0005085_abnormal_gallbladder_physiolo4.56800919
5MP0008057_abnormal_DNA_replication4.22932941
6MP0005365_abnormal_bile_salt4.03407751
7MP0002837_dystrophic_cardiac_calcinosis3.53022048
8MP0003646_muscle_fatigue3.49633912
9MP0010094_abnormal_chromosome_stability3.47907425
10MP0008058_abnormal_DNA_repair3.34313665
11MP0004084_abnormal_cardiac_muscle3.12604915
12MP0008875_abnormal_xenobiotic_pharmacok3.05485144
13MP0010234_abnormal_vibrissa_follicle3.05218922
14MP0003252_abnormal_bile_duct2.63845500
15MP0005332_abnormal_amino_acid2.57671533
16MP0010329_abnormal_lipoprotein_level2.43282910
17MP0005330_cardiomyopathy2.42832447
18MP0004036_abnormal_muscle_relaxation2.35170363
19MP0004215_abnormal_myocardial_fiber2.34003324
20MP0000749_muscle_degeneration2.33300634
21MP0009840_abnormal_foam_cell2.30201331
22MP0003111_abnormal_nucleus_morphology2.29639808
23MP0006036_abnormal_mitochondrial_physio2.27181420
24MP0000751_myopathy2.23920042
25MP0005083_abnormal_biliary_tract2.13735027
26MP0004130_abnormal_muscle_cell2.08583101
27MP0003195_calcinosis1.99245535
28MP0003077_abnormal_cell_cycle1.95981219
29MP0003705_abnormal_hypodermis_morpholog1.89815289
30MP0008007_abnormal_cellular_replicative1.87599843
31MP0002269_muscular_atrophy1.85138485
32MP0001661_extended_life_span1.83734545
33MP0004087_abnormal_muscle_fiber1.83603908
34MP0002877_abnormal_melanocyte_morpholog1.81974561
35MP0005319_abnormal_enzyme/_coenzyme1.81234881
36MP0008775_abnormal_heart_ventricle1.77099942
37MP0005187_abnormal_penis_morphology1.75079703
38MP0003221_abnormal_cardiomyocyte_apopto1.71476784
39MP0002009_preneoplasia1.68897409
40MP0002972_abnormal_cardiac_muscle1.65941133
41MP0000609_abnormal_liver_physiology1.63909745
42MP0003186_abnormal_redox_activity1.58340223
43MP0002118_abnormal_lipid_homeostasis1.58010077
44MP0006035_abnormal_mitochondrial_morpho1.56846912
45MP0008932_abnormal_embryonic_tissue1.56827023
46MP0001666_abnormal_nutrient_absorption1.54905407
47MP0010630_abnormal_cardiac_muscle1.54686249
48MP0001544_abnormal_cardiovascular_syste1.53974920
49MP0005385_cardiovascular_system_phenoty1.53974920
50MP0000372_irregular_coat_pigmentation1.51673433
51MP0005620_abnormal_muscle_contractility1.46268902
52MP0010678_abnormal_skin_adnexa1.45529289
53MP0005645_abnormal_hypothalamus_physiol1.44230123
54MP0006138_congestive_heart_failure1.43766254
55MP0008877_abnormal_DNA_methylation1.43716369
56MP0005670_abnormal_white_adipose1.40043867
57MP0000013_abnormal_adipose_tissue1.38352559
58MP0000647_abnormal_sebaceous_gland1.37750721
59MP0005584_abnormal_enzyme/coenzyme_acti1.36997974
60MP0005666_abnormal_adipose_tissue1.34565673
61MP0000747_muscle_weakness1.32368114
62MP0000750_abnormal_muscle_regeneration1.31605464
63MP0005266_abnormal_metabolism1.30172588
64MP0003191_abnormal_cellular_cholesterol1.27151549
65MP0003786_premature_aging1.27147067
66MP0005451_abnormal_body_composition1.27082334
67MP0009643_abnormal_urine_homeostasis1.25582460
68MP0003137_abnormal_impulse_conducting1.25179748
69MP0004019_abnormal_vitamin_homeostasis1.22069275
70MP0002106_abnormal_muscle_physiology1.21273219
71MP0001764_abnormal_homeostasis1.20700875
72MP0000427_abnormal_hair_cycle1.19467623
73MP0003941_abnormal_skin_development1.18941090
74MP0003656_abnormal_erythrocyte_physiolo1.18592052
75MP0009697_abnormal_copulation1.18517219
76MP0002138_abnormal_hepatobiliary_system1.13558568
77MP0005248_abnormal_Harderian_gland1.10891485
78MP0006072_abnormal_retinal_apoptosis1.10804325
79MP0000358_abnormal_cell_content/1.09740869
80MP0002095_abnormal_skin_pigmentation1.09192707
81MP0000598_abnormal_liver_morphology1.06534174
82MP0000383_abnormal_hair_follicle1.02282609
83MP0004233_abnormal_muscle_weight1.02000034
84MP0000759_abnormal_skeletal_muscle1.01051769
85MP0005379_endocrine/exocrine_gland_phen1.00132435
86MP0002332_abnormal_exercise_endurance1.00052920
87MP0002971_abnormal_brown_adipose0.99514504
88MP0010307_abnormal_tumor_latency0.97445499
89MP0009780_abnormal_chondrocyte_physiolo0.96368770
90MP0000569_abnormal_digit_pigmentation0.95461489
91MP0002127_abnormal_cardiovascular_syste0.94177959
92MP0004484_altered_response_of0.93125900
93MP0003567_abnormal_fetal_cardiomyocyte0.92886517
94MP0005369_muscle_phenotype0.90590265
95MP0000015_abnormal_ear_pigmentation0.90012871
96MP0002098_abnormal_vibrissa_morphology0.89264305
97MP0002396_abnormal_hematopoietic_system0.87214171
98MP0000350_abnormal_cell_proliferation0.86413789
99MP0001697_abnormal_embryo_size0.83712951
100MP0004043_abnormal_pH_regulation0.83040622
101MP0003868_abnormal_feces_composition0.82573684
102MP0004085_abnormal_heartbeat0.81443000
103MP0002078_abnormal_glucose_homeostasis0.81129655
104MP0004185_abnormal_adipocyte_glucose0.81007292
105MP0005376_homeostasis/metabolism_phenot0.80879120
106MP0001727_abnormal_embryo_implantation0.80295259
107MP0005171_absent_coat_pigmentation0.79677784
108MP0004134_abnormal_chest_morphology0.79214605
109MP0002080_prenatal_lethality0.79167115
110MP0005075_abnormal_melanosome_morpholog0.79161682
111MP0005253_abnormal_eye_physiology0.78915570
112MP0004197_abnormal_fetal_growth/weight/0.78257296
113MP0000627_abnormal_mammary_gland0.77620879
114MP0000377_abnormal_hair_follicle0.77028963
115MP0001730_embryonic_growth_arrest0.76455757
116MP0009763_increased_sensitivity_to0.75402821
117MP0000003_abnormal_adipose_tissue0.74373246
118MP0003984_embryonic_growth_retardation0.72645499
119MP0004145_abnormal_muscle_electrophysio0.72534079
120MP0004147_increased_porphyrin_level0.72485219
121MP0009672_abnormal_birth_weight0.72469593
122MP0009046_muscle_twitch0.72132434
123MP0002090_abnormal_vision0.71744825
124MP0001756_abnormal_urination0.71676033
125MP0002088_abnormal_embryonic_growth/wei0.71360993
126MP0003828_pulmonary_edema0.70708236
127MP0003566_abnormal_cell_adhesion0.70675060
128MP0005220_abnormal_exocrine_pancreas0.69963082
129MP0010368_abnormal_lymphatic_system0.69674858
130MP0000266_abnormal_heart_morphology0.68922277
131MP0002160_abnormal_reproductive_system0.68915577
132MP0004782_abnormal_surfactant_physiolog0.68243448
133MP0002086_abnormal_extraembryonic_tissu0.66708392
134MP0001929_abnormal_gametogenesis0.66326235
135MP0003718_maternal_effect0.66209482
136MP0005636_abnormal_mineral_homeostasis0.65591468
137MP0005375_adipose_tissue_phenotype0.64701343
138MP0010352_gastrointestinal_tract_polyps0.63047060
139MP0001672_abnormal_embryogenesis/_devel0.62752904
140MP0005380_embryogenesis_phenotype0.62752904
141MP0009642_abnormal_blood_homeostasis0.62536163
142MP0003950_abnormal_plasma_membrane0.61853454
143MP0005334_abnormal_fat_pad0.60257118
144MP0000343_altered_response_to0.58946038
145MP0005647_abnormal_sex_gland0.58876524
146MP0004957_abnormal_blastocyst_morpholog0.58138256
147MP0003693_abnormal_embryo_hatching0.56108057
148MP0005535_abnormal_body_temperature0.55837467
149MP0002970_abnormal_white_adipose0.54935121
150MP0005165_increased_susceptibility_to0.54877050
151MP0002128_abnormal_blood_circulation0.54349940
152MP0000230_abnormal_systemic_arterial0.54102446

Predicted human phenotypes

RankGene SetZ-score
1Hyperammonemia (HP:0001987)4.59846394
2Hyperglycinuria (HP:0003108)4.58940581
3Hypoglycemic coma (HP:0001325)4.48897992
4Intrahepatic cholestasis (HP:0001406)4.43479963
5Myoglobinuria (HP:0002913)4.40509977
6Exercise-induced muscle cramps (HP:0003710)4.27117285
7Abnormality of serine family amino acid metabolism (HP:0010894)4.21417025
8Abnormality of glycine metabolism (HP:0010895)4.21417025
9Ketosis (HP:0001946)4.16787670
10Deep venous thrombosis (HP:0002625)4.12093887
11Abnormality of fatty-acid metabolism (HP:0004359)4.04765303
12Hyperglycinemia (HP:0002154)4.02359901
13Rhabdomyolysis (HP:0003201)4.00668676
14Hypobetalipoproteinemia (HP:0003563)3.99323412
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.98765118
16Ketoacidosis (HP:0001993)3.96601019
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.93245457
18Nemaline bodies (HP:0003798)3.88085258
19Xanthomatosis (HP:0000991)3.88008702
20Muscle fiber inclusion bodies (HP:0100299)3.85933054
21Sudden death (HP:0001699)3.81381292
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.73877715
23Abnormality of dicarboxylic acid metabolism (HP:0010995)3.65140976
24Dicarboxylic aciduria (HP:0003215)3.65140976
25Exercise-induced myalgia (HP:0003738)3.53369095
26Hypolipoproteinemia (HP:0010981)3.53247879
27Ventricular tachycardia (HP:0004756)3.47198992
28Hypoalphalipoproteinemia (HP:0003233)3.44463083
29Cerebral edema (HP:0002181)3.40754861
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.25946431
31Abnormality of serum amino acid levels (HP:0003112)3.23201822
32Hyperlipoproteinemia (HP:0010980)3.16039592
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.11128000
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.10034114
35Abnormality of sulfur amino acid metabolism (HP:0004339)3.08413220
36Hepatic necrosis (HP:0002605)3.05806218
37Lethargy (HP:0001254)3.00838996
38Abnormality of methionine metabolism (HP:0010901)3.00585260
39Right ventricular cardiomyopathy (HP:0011663)2.97499249
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.96901117
41Microvesicular hepatic steatosis (HP:0001414)2.95791194
42Complement deficiency (HP:0004431)2.94196714
43Calf muscle hypertrophy (HP:0008981)2.91923231
44Palpitations (HP:0001962)2.88449707
45Lipid accumulation in hepatocytes (HP:0006561)2.87167423
46Nausea (HP:0002018)2.86387750
47Generalized aminoaciduria (HP:0002909)2.86038892
48Progressive muscle weakness (HP:0003323)2.85642078
49Prolonged partial thromboplastin time (HP:0003645)2.85166682
50Abnormality of glycolysis (HP:0004366)2.83008288
51Increased serum pyruvate (HP:0003542)2.83008288
52Lipoatrophy (HP:0100578)2.82572622
53* Metabolic acidosis (HP:0001942)2.81909573
54Glioma (HP:0009733)2.79004958
55Proximal tubulopathy (HP:0000114)2.72417844
56Abnormality of pyrimidine metabolism (HP:0004353)2.70028180
57Epidermoid cyst (HP:0200040)2.68465848
58Acute encephalopathy (HP:0006846)2.67306882
59Gout (HP:0001997)2.66177834
60Muscle hypertrophy of the lower extremities (HP:0008968)2.62310557
61Ragged-red muscle fibers (HP:0003200)2.62294856
62Cholelithiasis (HP:0001081)2.60131727
63Increased hepatocellular lipid droplets (HP:0006565)2.58771630
64Pheochromocytoma (HP:0002666)2.58331763
65Hyporeflexia of lower limbs (HP:0002600)2.58275976
66Increased muscle lipid content (HP:0009058)2.56209519
67Muscle fiber splitting (HP:0003555)2.53763216
68Increased connective tissue (HP:0009025)2.52114070
69Atrial fibrillation (HP:0005110)2.51365777
70Dilated cardiomyopathy (HP:0001644)2.51334849
71Neuroendocrine neoplasm (HP:0100634)2.48944680
72Neoplasm of the adrenal gland (HP:0100631)2.47171494
73Abnormality of nucleobase metabolism (HP:0010932)2.46559087
74Abnormal gallbladder morphology (HP:0012437)2.43672539
75Skin nodule (HP:0200036)2.41200838
76Chromsome breakage (HP:0040012)2.38187603
77Lactic acidosis (HP:0003128)2.37323504
78Hyperbilirubinemia (HP:0002904)2.37195044
79Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36967793
80Medulloblastoma (HP:0002885)2.36856569
81Abnormal protein glycosylation (HP:0012346)2.36227241
82Abnormal glycosylation (HP:0012345)2.36227241
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36227241
84Abnormal protein N-linked glycosylation (HP:0012347)2.36227241
85Vomiting (HP:0002013)2.36081090
86Conjunctival hamartoma (HP:0100780)2.35717156
87Abnormality of the astrocytes (HP:0100707)2.35385593
88Astrocytoma (HP:0009592)2.35385593
89Abnormality of purine metabolism (HP:0004352)2.34824540
90Delayed CNS myelination (HP:0002188)2.34320274
91Reduced antithrombin III activity (HP:0001976)2.32006434
92Abnormal mitochondria in muscle tissue (HP:0008316)2.30173102
93Fat malabsorption (HP:0002630)2.29898924
94Type I transferrin isoform profile (HP:0003642)2.28245735
95Papillary thyroid carcinoma (HP:0002895)2.26883854
96Hepatocellular necrosis (HP:0001404)2.26857960
97Primary atrial arrhythmia (HP:0001692)2.25512362
98Abnormality of the common coagulation pathway (HP:0010990)2.24836867
99Abnormality of the calf musculature (HP:0001430)2.24110350
100Abnormality of the left ventricular outflow tract (HP:0011103)2.21998292
101Subaortic stenosis (HP:0001682)2.21998292
102* Increased serum lactate (HP:0002151)2.21816471
103Renal cortical cysts (HP:0000803)2.20969806
104Supraventricular tachycardia (HP:0004755)2.20800399
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20473253
106Abnormality of alanine metabolism (HP:0010916)2.20473253
107Hyperalaninemia (HP:0003348)2.20473253
108Abnormality of complement system (HP:0005339)2.20397324
109Hepatocellular carcinoma (HP:0001402)2.18905223
110Abnormality of chromosome stability (HP:0003220)2.18236350
111EMG: myopathic abnormalities (HP:0003458)2.17683397
112Rimmed vacuoles (HP:0003805)2.17519134
113Hyperglycemia (HP:0003074)2.17232842
114Increased purine levels (HP:0004368)2.16945810
115Hyperuricemia (HP:0002149)2.16945810
116Asymmetric septal hypertrophy (HP:0001670)2.16945410
117Supraventricular arrhythmia (HP:0005115)2.16023991
118Atrioventricular block (HP:0001678)2.15664082
119Hyperinsulinemic hypoglycemia (HP:0000825)2.12106145
120Increased intramyocellular lipid droplets (HP:0012240)2.10660252
121Acute necrotizing encephalopathy (HP:0006965)2.09953267
122Abnormal gallbladder physiology (HP:0012438)2.09670200
123Cholecystitis (HP:0001082)2.09670200
124Syncope (HP:0001279)2.09259494
125Glycosuria (HP:0003076)2.09151377
126Abnormality of urine glucose concentration (HP:0011016)2.09151377
127Abnormality of the intrinsic pathway (HP:0010989)2.07911281
128* Increased CSF lactate (HP:0002490)2.07357920
129Neoplasm of the peripheral nervous system (HP:0100007)2.04203919
130Volvulus (HP:0002580)1.99245740
131Bundle branch block (HP:0011710)1.96111484
132Exercise intolerance (HP:0003546)1.95373040
133Hypoplasia of the pons (HP:0012110)1.90073382
134Neoplasm of the small intestine (HP:0100833)1.89498639
135Colon cancer (HP:0003003)1.84720499
136Progressive inability to walk (HP:0002505)1.82283408
137Neoplasm of the adrenal cortex (HP:0100641)1.81899666
138Horizontal nystagmus (HP:0000666)1.80895906
139Thyroid carcinoma (HP:0002890)1.80141093
140Abnormality of the pons (HP:0007361)1.79272441
141Abnormality of the renal cortex (HP:0011035)1.78799251
142Cerebellar dysplasia (HP:0007033)1.76690673
143Shoulder girdle muscle weakness (HP:0003547)1.76164238
144Type II lissencephaly (HP:0007260)1.75959204
145Entropion (HP:0000621)1.70999631
146CNS demyelination (HP:0007305)1.69575271
147Methylmalonic acidemia (HP:0002912)1.69133103
148Patchy hypopigmentation of hair (HP:0011365)1.68741009
149Progressive macrocephaly (HP:0004481)1.68708263
150Insidious onset (HP:0003587)1.66217245
151Termporal pattern (HP:0011008)1.66217245
152Degeneration of anterior horn cells (HP:0002398)1.65353681
153Abnormality of the anterior horn cell (HP:0006802)1.65353681
154Distal arthrogryposis (HP:0005684)1.62706115
155Mitochondrial inheritance (HP:0001427)1.61884697
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.60169731
157Breast carcinoma (HP:0003002)1.59594514
158Pelvic girdle muscle weakness (HP:0003749)1.58640349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.31560244
2NEK14.37077377
3PKN24.09693008
4PDK33.90791047
5PDK43.90791047
6TTN3.70360884
7OBSCN3.61676051
8TRIB32.80498582
9TRIM282.74609287
10PDK22.27241527
11EIF2AK12.10560489
12STK38L2.08000224
13NEK92.06894047
14FLT32.02633880
15SRPK11.92241653
16PNCK1.91034266
17PBK1.89224427
18MYLK1.87145155
19LMTK21.79251586
20STK391.74914596
21ZAK1.73746836
22FRK1.71772476
23PHKG11.69531267
24PHKG21.69531267
25MKNK21.66872794
26CCNB11.62891191
27STK241.59899332
28MST41.53427952
29SIK11.49251512
30BMPR1B1.45152776
31MUSK1.44858203
32PINK11.43874932
33FGFR41.40540510
34PIK3CA1.32280881
35MAP2K31.23300566
36CDC71.21696416
37ERBB41.21507607
38ATR1.19507257
39TTK1.19143900
40WEE11.17310180
41MAP3K121.17142282
42BCR1.16456842
43MKNK11.15818320
44CSNK1A1L1.11511386
45DMPK1.11272004
46CSNK1G31.07905843
47LATS11.06016813
48CSNK1G11.04708435
49ERN11.03051633
50STK41.02333411
51AKT30.94913973
52KDR0.94030612
53CDK40.91837793
54TSSK60.91569236
55RIPK10.90930996
56ACVR1B0.90720923
57BRD40.90143853
58NEK60.89102616
59MAPK110.88747822
60FER0.88001271
61CAMKK20.87822916
62EIF2AK20.85334771
63NEK20.84595699
64STK160.83279158
65MAP3K50.82427551
66BUB10.81864926
67CSNK1G20.81286660
68CHEK20.80405277
69ATM0.79757217
70MAP3K30.79606704
71MAP4K20.77948019
72NME20.77717363
73CHEK10.76410352
74MAP3K110.74203284
75NUAK10.72960326
76TIE10.71083041
77PRKAA10.70508037
78VRK10.69628632
79RAF10.69427497
80MAP3K80.69313242
81PLK40.68725347
82OXSR10.68111213
83MAP3K70.67698942
84PRKAA20.67558395
85PLK20.66545725
86CDK80.65793827
87PTK60.62351739
88BRSK10.60150682
89MAP3K90.60089440
90ILK0.59445613
91PDGFRA0.58651927
92MAP2K40.58583355
93TGFBR10.58304597
94STK30.58217347
95PIK3CG0.57982959
96ABL20.57927341
97AURKB0.57564462
98RPS6KA40.57559965
99LATS20.55520731
100AKT20.55500080
101RPS6KB20.53946223
102TRPM70.53351750
103CAMK2D0.52714805
104BRSK20.52436976
105TYK20.50138339
106MST1R0.48504046
107PAK30.48307339
108MAPK120.47420516
109LRRK20.47413196
110MAP3K100.47243524
111PRKACG0.46879180
112PRKCI0.46780835
113CDK10.46170253
114WNK40.46002815
115PLK10.45919779
116MTOR0.45530852
117MAPKAPK50.44483750
118INSRR0.44157572
119TAOK20.42687523
120CDK70.41931812
121CDK60.41357860
122CSNK1E0.40016478
123FGFR10.39701426
124MAPKAPK30.39249962
125RPS6KB10.39075932
126SCYL20.38318885
127CLK10.37649842
128KSR10.36946500
129STK100.36013695
130PIM20.35654625
131CAMK40.35629076
132JAK20.35614816
133PLK30.35052467
134PRKD10.35039771
135TAF10.34854887
136EEF2K0.34752678
137RPS6KA50.34728848
138PRKCE0.34477089
139PRKDC0.34401653
140PRKACB0.34253513
141CDK20.32834680
142SGK30.32022800
143ERBB30.31941979
144DAPK30.31650759
145ROCK10.28116090
146EIF2AK30.26127782
147WNK30.25696066
148ALK0.25175702
149CAMK2G0.25127795
150MAP2K10.23253812
151LIMK10.23050712
152STK380.22628676
153MET0.22515265
154NME10.22334969
155EPHA20.22045847

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.85883624
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.68243533
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.63974610
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.18098258
5Fatty acid degradation_Homo sapiens_hsa000713.15041673
6Propanoate metabolism_Homo sapiens_hsa006403.07502342
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.93612969
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.92401768
9Arginine biosynthesis_Homo sapiens_hsa002202.54255585
10Non-homologous end-joining_Homo sapiens_hsa034502.47795315
11Carbon metabolism_Homo sapiens_hsa012002.47041663
12Nitrogen metabolism_Homo sapiens_hsa009102.46419524
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.34534903
14Fatty acid metabolism_Homo sapiens_hsa012122.32566287
15Tryptophan metabolism_Homo sapiens_hsa003802.22880344
16Pyruvate metabolism_Homo sapiens_hsa006202.20446732
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19899024
18Butanoate metabolism_Homo sapiens_hsa006502.16714390
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05499823
20Biosynthesis of amino acids_Homo sapiens_hsa012302.01746451
21Protein export_Homo sapiens_hsa030601.87202995
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86598542
23Peroxisome_Homo sapiens_hsa041461.85308303
24Nucleotide excision repair_Homo sapiens_hsa034201.79314236
25PPAR signaling pathway_Homo sapiens_hsa033201.78962495
26Homologous recombination_Homo sapiens_hsa034401.72783913
27Fanconi anemia pathway_Homo sapiens_hsa034601.70662968
28beta-Alanine metabolism_Homo sapiens_hsa004101.65462121
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61479496
30RNA degradation_Homo sapiens_hsa030181.60689423
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59806476
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.58003670
33Basal transcription factors_Homo sapiens_hsa030221.55870853
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55755899
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52395722
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52091013
37Complement and coagulation cascades_Homo sapiens_hsa046101.51192486
38One carbon pool by folate_Homo sapiens_hsa006701.46761030
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.43599325
40Selenocompound metabolism_Homo sapiens_hsa004501.40999511
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38249609
42Starch and sucrose metabolism_Homo sapiens_hsa005001.34549957
43Phenylalanine metabolism_Homo sapiens_hsa003601.31750845
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.30529189
45Fatty acid elongation_Homo sapiens_hsa000621.22832284
46RNA polymerase_Homo sapiens_hsa030201.21983175
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20178009
48Spliceosome_Homo sapiens_hsa030401.18880565
49Cell cycle_Homo sapiens_hsa041101.13976641
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13941314
51Tyrosine metabolism_Homo sapiens_hsa003501.05928409
52Chemical carcinogenesis_Homo sapiens_hsa052041.04973660
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03655928
54Arginine and proline metabolism_Homo sapiens_hsa003301.02361861
55Bile secretion_Homo sapiens_hsa049761.00320375
56Folate biosynthesis_Homo sapiens_hsa007900.97701287
57Caffeine metabolism_Homo sapiens_hsa002320.97178069
58Pentose phosphate pathway_Homo sapiens_hsa000300.95968606
59Parkinsons disease_Homo sapiens_hsa050120.95731772
60Lysine degradation_Homo sapiens_hsa003100.94358182
61mRNA surveillance pathway_Homo sapiens_hsa030150.90209157
62Cardiac muscle contraction_Homo sapiens_hsa042600.89106640
63Histidine metabolism_Homo sapiens_hsa003400.87733447
64Vitamin B6 metabolism_Homo sapiens_hsa007500.85852062
65Fat digestion and absorption_Homo sapiens_hsa049750.85156331
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84571395
67Oxidative phosphorylation_Homo sapiens_hsa001900.83929530
68Retinol metabolism_Homo sapiens_hsa008300.82746580
69Oocyte meiosis_Homo sapiens_hsa041140.80336649
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.79754342
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79373445
72Staphylococcus aureus infection_Homo sapiens_hsa051500.79210808
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76498319
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75328286
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74993464
76Glutathione metabolism_Homo sapiens_hsa004800.73264277
77Sulfur metabolism_Homo sapiens_hsa009200.72284411
78N-Glycan biosynthesis_Homo sapiens_hsa005100.71318376
79Fatty acid biosynthesis_Homo sapiens_hsa000610.69888326
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68807455
81Circadian rhythm_Homo sapiens_hsa047100.66844087
82Fructose and mannose metabolism_Homo sapiens_hsa000510.65509151
83Galactose metabolism_Homo sapiens_hsa000520.62700963
84Sulfur relay system_Homo sapiens_hsa041220.60307370
85Glycerolipid metabolism_Homo sapiens_hsa005610.60136485
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58386196
87Metabolic pathways_Homo sapiens_hsa011000.55618131
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53031665
89ABC transporters_Homo sapiens_hsa020100.52124542
90Dilated cardiomyopathy_Homo sapiens_hsa054140.51579665
91Huntingtons disease_Homo sapiens_hsa050160.51314240
92Alzheimers disease_Homo sapiens_hsa050100.48314656
93Glucagon signaling pathway_Homo sapiens_hsa049220.47554157
94Insulin resistance_Homo sapiens_hsa049310.44913225
95p53 signaling pathway_Homo sapiens_hsa041150.43061706
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41697778
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.40544130
98Vitamin digestion and absorption_Homo sapiens_hsa049770.39501459
99Sphingolipid metabolism_Homo sapiens_hsa006000.37827095
100Regulation of autophagy_Homo sapiens_hsa041400.37331315
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36782084
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35585071
103Proteasome_Homo sapiens_hsa030500.32458467
104DNA replication_Homo sapiens_hsa030300.31392824
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.30036990
106AMPK signaling pathway_Homo sapiens_hsa041520.26223119
107Insulin signaling pathway_Homo sapiens_hsa049100.20568893
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18008758
109Pyrimidine metabolism_Homo sapiens_hsa002400.16121472
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14418176
111Mismatch repair_Homo sapiens_hsa034300.12172030
112Steroid biosynthesis_Homo sapiens_hsa001000.11445041
113RNA transport_Homo sapiens_hsa030130.11078797
114Viral myocarditis_Homo sapiens_hsa054160.08994211
115Systemic lupus erythematosus_Homo sapiens_hsa053220.08250561
116HIF-1 signaling pathway_Homo sapiens_hsa040660.03344783
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.02944333
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.02550791
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00941627
120Base excision repair_Homo sapiens_hsa03410-0.0639660
121Purine metabolism_Homo sapiens_hsa00230-0.0408649
122alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0320374

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