

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 5.56678780 |
| 2 | locomotory exploration behavior (GO:0035641) | 5.55948807 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.49968751 |
| 4 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.38742981 |
| 5 | glutamate secretion (GO:0014047) | 5.03029398 |
| 6 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.97033635 |
| 7 | vocalization behavior (GO:0071625) | 4.96901107 |
| 8 | neuronal action potential propagation (GO:0019227) | 4.88727825 |
| 9 | synaptic vesicle exocytosis (GO:0016079) | 4.82327518 |
| 10 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.71176354 |
| 11 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.63753491 |
| 12 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.60859807 |
| 13 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.40292792 |
| 14 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.33037174 |
| 15 | glutamate receptor signaling pathway (GO:0007215) | 4.25184834 |
| 16 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.18712915 |
| 17 | protein localization to synapse (GO:0035418) | 4.14429331 |
| 18 | synaptic transmission, glutamatergic (GO:0035249) | 4.07556740 |
| 19 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.03963782 |
| 20 | regulation of synaptic vesicle transport (GO:1902803) | 4.03707274 |
| 21 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.02003504 |
| 22 | exploration behavior (GO:0035640) | 3.98507265 |
| 23 | regulation of synapse structural plasticity (GO:0051823) | 3.96836944 |
| 24 | neurotransmitter secretion (GO:0007269) | 3.93460123 |
| 25 | long-term memory (GO:0007616) | 3.92984648 |
| 26 | cellular potassium ion homeostasis (GO:0030007) | 3.90990792 |
| 27 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.79663256 |
| 28 | dendritic spine morphogenesis (GO:0060997) | 3.79600437 |
| 29 | sodium ion export (GO:0071436) | 3.79100776 |
| 30 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.76448782 |
| 31 | neuron-neuron synaptic transmission (GO:0007270) | 3.74668772 |
| 32 | regulation of female receptivity (GO:0045924) | 3.72045727 |
| 33 | layer formation in cerebral cortex (GO:0021819) | 3.71965921 |
| 34 | positive regulation of membrane potential (GO:0045838) | 3.66961632 |
| 35 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.66570061 |
| 36 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.66299420 |
| 37 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.62891956 |
| 38 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.62844630 |
| 39 | neuron cell-cell adhesion (GO:0007158) | 3.61845459 |
| 40 | gamma-aminobutyric acid transport (GO:0015812) | 3.61000661 |
| 41 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.60141189 |
| 42 | relaxation of cardiac muscle (GO:0055119) | 3.58154959 |
| 43 | cerebellar granule cell differentiation (GO:0021707) | 3.55924870 |
| 44 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.54372563 |
| 45 | regulation of postsynaptic membrane potential (GO:0060078) | 3.49958938 |
| 46 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.46796295 |
| 47 | transmission of nerve impulse (GO:0019226) | 3.44363585 |
| 48 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.42447055 |
| 49 | cell communication by electrical coupling (GO:0010644) | 3.38982476 |
| 50 | activation of protein kinase A activity (GO:0034199) | 3.38617107 |
| 51 | membrane depolarization during action potential (GO:0086010) | 3.36813395 |
| 52 | regulation of synaptic plasticity (GO:0048167) | 3.34999719 |
| 53 | regulation of membrane repolarization (GO:0060306) | 3.34943072 |
| 54 | serotonin metabolic process (GO:0042428) | 3.33310890 |
| 55 | regulation of synapse maturation (GO:0090128) | 3.32233776 |
| 56 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.30053719 |
| 57 | behavioral response to nicotine (GO:0035095) | 3.26942428 |
| 58 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 3.26686153 |
| 59 | neuromuscular process controlling balance (GO:0050885) | 3.26627433 |
| 60 | proline transport (GO:0015824) | 3.20602575 |
| 61 | regulation of ARF protein signal transduction (GO:0032012) | 3.18657211 |
| 62 | membrane depolarization (GO:0051899) | 3.18539008 |
| 63 | regulation of dendritic spine development (GO:0060998) | 3.18499779 |
| 64 | regulation of neurotransmitter secretion (GO:0046928) | 3.18295569 |
| 65 | cardiac conduction (GO:0061337) | 3.17888985 |
| 66 | cAMP catabolic process (GO:0006198) | 3.12506516 |
| 67 | primary amino compound metabolic process (GO:1901160) | 3.11136733 |
| 68 | neurotransmitter transport (GO:0006836) | 3.10268866 |
| 69 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.10204400 |
| 70 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.09837837 |
| 71 | potassium ion import (GO:0010107) | 3.09517708 |
| 72 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.09182430 |
| 73 | L-amino acid import (GO:0043092) | 3.08459785 |
| 74 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 3.07745209 |
| 75 | long-term synaptic potentiation (GO:0060291) | 3.07519610 |
| 76 | female mating behavior (GO:0060180) | 3.06553049 |
| 77 | positive regulation of dendritic spine development (GO:0060999) | 3.04697967 |
| 78 | regulation of cell communication by electrical coupling (GO:0010649) | 3.03896585 |
| 79 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.03316116 |
| 80 | cyclic nucleotide catabolic process (GO:0009214) | 3.02389132 |
| 81 | adult walking behavior (GO:0007628) | 3.01905226 |
| 82 | positive regulation of synapse maturation (GO:0090129) | 3.01366508 |
| 83 | dendrite morphogenesis (GO:0048813) | 3.01235371 |
| 84 | neuromuscular process controlling posture (GO:0050884) | 2.99026419 |
| 85 | cardiac muscle cell action potential (GO:0086001) | 2.97276600 |
| 86 | regulation of vesicle fusion (GO:0031338) | 2.97108708 |
| 87 | synaptic vesicle endocytosis (GO:0048488) | 2.96549209 |
| 88 | long term synaptic depression (GO:0060292) | 2.94811461 |
| 89 | multicellular organismal signaling (GO:0035637) | 2.93768757 |
| 90 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.93663113 |
| 91 | cardiac muscle hypertrophy (GO:0003300) | 2.91657026 |
| 92 | action potential (GO:0001508) | 2.91416535 |
| 93 | potassium ion homeostasis (GO:0055075) | 2.90617883 |
| 94 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.90456771 |
| 95 | cellular sodium ion homeostasis (GO:0006883) | 2.90319855 |
| 96 | neuronal ion channel clustering (GO:0045161) | 2.90189967 |
| 97 | regulation of neurotransmitter transport (GO:0051588) | 2.90054220 |
| 98 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.89152770 |
| 99 | regulation of neurotransmitter levels (GO:0001505) | 2.88971374 |
| 100 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 2.88960763 |
| 101 | glycine transport (GO:0015816) | 2.88588579 |
| 102 | regulation of sodium ion transmembrane transporter activity (GO:2000649) | 2.88097190 |
| 103 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.87926179 |
| 104 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.86427766 |
| 105 | dendritic spine organization (GO:0097061) | 2.85121660 |
| 106 | neuron recognition (GO:0008038) | 2.84547532 |
| 107 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 2.83035388 |
| 108 | vesicle transport along microtubule (GO:0047496) | 2.82632563 |
| 109 | regulation of heart rate by cardiac conduction (GO:0086091) | 2.82416599 |
| 110 | detection of calcium ion (GO:0005513) | 2.81976044 |
| 111 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 2.81672152 |
| 112 | regulation of calcium ion transmembrane transport (GO:1903169) | 2.81672152 |
| 113 | learning (GO:0007612) | 2.81365600 |
| 114 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 2.80150139 |
| 115 | cell communication involved in cardiac conduction (GO:0086065) | 2.79988745 |
| 116 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.79126120 |
| 117 | membrane hyperpolarization (GO:0060081) | 2.78396536 |
| 118 | establishment of nucleus localization (GO:0040023) | 2.77129961 |
| 119 | cell differentiation in hindbrain (GO:0021533) | 2.76766986 |
| 120 | regulation of synaptic transmission (GO:0050804) | 2.76380462 |
| 121 | synaptic transmission (GO:0007268) | 2.75447281 |
| 122 | chemosensory behavior (GO:0007635) | 2.75037802 |
| 123 | regulation of relaxation of muscle (GO:1901077) | 2.74827114 |
| 124 | neuronal action potential (GO:0019228) | 2.74729944 |
| 125 | presynaptic membrane assembly (GO:0097105) | 2.73843196 |
| 126 | striated muscle hypertrophy (GO:0014897) | 2.73805802 |
| 127 | regulation of ion transmembrane transporter activity (GO:0032412) | 2.70984906 |
| 128 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.69747123 |
| 129 | startle response (GO:0001964) | 2.69661561 |
| 130 | sleep (GO:0030431) | 2.69488883 |
| 131 | regulation of actin filament-based movement (GO:1903115) | 2.66928730 |
| 132 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 2.65774130 |
| 133 | regulation of sodium ion transmembrane transport (GO:1902305) | 2.65343389 |
| 134 | cardiac muscle contraction (GO:0060048) | 2.64777693 |
| 135 | regulation of potassium ion transmembrane transport (GO:1901379) | 2.63566045 |
| 136 | parturition (GO:0007567) | 2.62263880 |
| 137 | axon ensheathment in central nervous system (GO:0032291) | 2.60658858 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.57119055 |
| 2 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.03845190 |
| 3 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.00764214 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.00716649 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.99473957 |
| 6 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.78946730 |
| 7 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.70920611 |
| 8 | * EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.70079786 |
| 9 | * RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.70079786 |
| 10 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.57099759 |
| 11 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.49747215 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.48769437 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.45587103 |
| 14 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.45452888 |
| 15 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.40842176 |
| 16 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.36648702 |
| 17 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.33997351 |
| 18 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.29915905 |
| 19 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.22701242 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.20935149 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.20857802 |
| 22 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.18501164 |
| 23 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.14557895 |
| 24 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.09796145 |
| 25 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.04515396 |
| 26 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.99518943 |
| 27 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.98282351 |
| 28 | VDR_22108803_ChIP-Seq_LS180_Human | 1.90841633 |
| 29 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.80258952 |
| 30 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.78517107 |
| 31 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.61318174 |
| 32 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.58863104 |
| 33 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.53360800 |
| 34 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.52439036 |
| 35 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.49325564 |
| 36 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.47292114 |
| 37 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.44866411 |
| 38 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.43124200 |
| 39 | KDM2B_26808549_Chip-Seq_K562_Human | 1.40648377 |
| 40 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.40229125 |
| 41 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.37928681 |
| 42 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.37263750 |
| 43 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.36158168 |
| 44 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.34737941 |
| 45 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.33763104 |
| 46 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.33531158 |
| 47 | * NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.31694744 |
| 48 | * TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.31039138 |
| 49 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.30913169 |
| 50 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.30730984 |
| 51 | * GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.29847318 |
| 52 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.27380310 |
| 53 | * RNF2_27304074_Chip-Seq_NSC_Mouse | 1.27086209 |
| 54 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.26552137 |
| 55 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.25391590 |
| 56 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.24983823 |
| 57 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.24868704 |
| 58 | TP53_16413492_ChIP-PET_HCT116_Human | 1.23981407 |
| 59 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.23914929 |
| 60 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.22371758 |
| 61 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.20894577 |
| 62 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.20519959 |
| 63 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.20020340 |
| 64 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.19959567 |
| 65 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.19900534 |
| 66 | * AR_19668381_ChIP-Seq_PC3_Human | 1.17517603 |
| 67 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.16718527 |
| 68 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.16281066 |
| 69 | * LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15912233 |
| 70 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.15290281 |
| 71 | STAT3_23295773_ChIP-Seq_U87_Human | 1.13691745 |
| 72 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.13426272 |
| 73 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.12780452 |
| 74 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.12662659 |
| 75 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.12315172 |
| 76 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.12151538 |
| 77 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.11887872 |
| 78 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.11051250 |
| 79 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.10316489 |
| 80 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.09991013 |
| 81 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.09513027 |
| 82 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.09472304 |
| 83 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.08155926 |
| 84 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.07780441 |
| 85 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.07318449 |
| 86 | P300_19829295_ChIP-Seq_ESCs_Human | 1.06909836 |
| 87 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.05729322 |
| 88 | AR_25329375_ChIP-Seq_VCAP_Human | 1.04741039 |
| 89 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.04271085 |
| 90 | * MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.03656852 |
| 91 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.02852028 |
| 92 | GATA1_22025678_ChIP-Seq_K562_Human | 1.01789032 |
| 93 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.01635918 |
| 94 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.01276209 |
| 95 | TCF4_23295773_ChIP-Seq_U87_Human | 1.01086210 |
| 96 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.00976074 |
| 97 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.00804314 |
| 98 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.00495270 |
| 99 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.00198948 |
| 100 | RXR_22108803_ChIP-Seq_LS180_Human | 0.99986157 |
| 101 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.99234736 |
| 102 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.98112191 |
| 103 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.96964121 |
| 104 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.96951476 |
| 105 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.95981851 |
| 106 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.95970105 |
| 107 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.95812890 |
| 108 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.95332122 |
| 109 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.95277627 |
| 110 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.95255309 |
| 111 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.95041450 |
| 112 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.94637424 |
| 113 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.92206189 |
| 114 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.92074828 |
| 115 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.92074828 |
| 116 | KDM2B_26808549_Chip-Seq_REH_Human | 0.91967566 |
| 117 | * ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.89959775 |
| 118 | RUNX_20019798_ChIP-Seq_JUKART_Human | 0.89437079 |
| 119 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.89018762 |
| 120 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.88151866 |
| 121 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.88131388 |
| 122 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.87395117 |
| 123 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.87204886 |
| 124 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.86370560 |
| 125 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.85666182 |
| 126 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.85096164 |
| 127 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.83580230 |
| 128 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.82745249 |
| 129 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.81867242 |
| 130 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81194457 |
| 131 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.80363364 |
| 132 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.79281185 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.99961664 |
| 2 | MP0003880_abnormal_central_pattern | 4.49029596 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.10781969 |
| 4 | MP0004270_analgesia | 3.92912662 |
| 5 | MP0009745_abnormal_behavioral_response | 3.36252193 |
| 6 | MP0009046_muscle_twitch | 3.31503627 |
| 7 | MP0002064_seizures | 3.15327164 |
| 8 | MP0002063_abnormal_learning/memory/cond | 3.13758264 |
| 9 | MP0001968_abnormal_touch/_nociception | 2.95733271 |
| 10 | MP0002272_abnormal_nervous_system | 2.79149362 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.62167362 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.56239758 |
| 13 | MP0001486_abnormal_startle_reflex | 2.49778352 |
| 14 | MP0002735_abnormal_chemical_nociception | 2.45441292 |
| 15 | MP0008569_lethality_at_weaning | 2.42755668 |
| 16 | MP0001501_abnormal_sleep_pattern | 2.37444731 |
| 17 | MP0002822_catalepsy | 2.37050977 |
| 18 | MP0005423_abnormal_somatic_nervous | 2.32828485 |
| 19 | MP0002736_abnormal_nociception_after | 2.23129693 |
| 20 | MP0001986_abnormal_taste_sensitivity | 2.13653451 |
| 21 | MP0001440_abnormal_grooming_behavior | 2.12640571 |
| 22 | MP0003329_amyloid_beta_deposits | 2.02665138 |
| 23 | MP0002067_abnormal_sensory_capabilities | 2.00920974 |
| 24 | MP0004510_myositis | 1.97028695 |
| 25 | MP0001970_abnormal_pain_threshold | 1.8883389 |
| 26 | MP0002733_abnormal_thermal_nociception | 1.88748466 |
| 27 | MP0000751_myopathy | 1.85718191 |
| 28 | MP0004924_abnormal_behavior | 1.75813125 |
| 29 | MP0005386_behavior/neurological_phenoty | 1.75813125 |
| 30 | MP0009780_abnormal_chondrocyte_physiolo | 1.69488140 |
| 31 | MP0002184_abnormal_innervation | 1.68301357 |
| 32 | MP0004811_abnormal_neuron_physiology | 1.64089483 |
| 33 | MP0002876_abnormal_thyroid_physiology | 1.61238194 |
| 34 | MP0000569_abnormal_digit_pigmentation | 1.58706447 |
| 35 | MP0002837_dystrophic_cardiac_calcinosis | 1.56690186 |
| 36 | MP0002909_abnormal_adrenal_gland | 1.53664134 |
| 37 | MP0002638_abnormal_pupillary_reflex | 1.52845781 |
| 38 | MP0004215_abnormal_myocardial_fiber | 1.48610670 |
| 39 | MP0004858_abnormal_nervous_system | 1.43921293 |
| 40 | MP0004145_abnormal_muscle_electrophysio | 1.43543527 |
| 41 | MP0000920_abnormal_myelination | 1.42344039 |
| 42 | MP0003633_abnormal_nervous_system | 1.42007530 |
| 43 | MP0002066_abnormal_motor_capabilities/c | 1.41612593 |
| 44 | MP0000955_abnormal_spinal_cord | 1.41279253 |
| 45 | MP0000778_abnormal_nervous_system | 1.40624604 |
| 46 | MP0002557_abnormal_social/conspecific_i | 1.40080065 |
| 47 | MP0004885_abnormal_endolymph | 1.38473704 |
| 48 | MP0005670_abnormal_white_adipose | 1.36401489 |
| 49 | MP0003879_abnormal_hair_cell | 1.34273302 |
| 50 | MP0003646_muscle_fatigue | 1.33596583 |
| 51 | MP0006292_abnormal_olfactory_placode | 1.31983073 |
| 52 | MP0002882_abnormal_neuron_morphology | 1.30424328 |
| 53 | MP0004147_increased_porphyrin_level | 1.25491773 |
| 54 | MP0004142_abnormal_muscle_tone | 1.21831258 |
| 55 | MP0003631_nervous_system_phenotype | 1.21777857 |
| 56 | MP0008877_abnormal_DNA_methylation | 1.20863797 |
| 57 | MP0001905_abnormal_dopamine_level | 1.20762909 |
| 58 | MP0001984_abnormal_olfaction | 1.20629598 |
| 59 | MP0003787_abnormal_imprinting | 1.20165797 |
| 60 | MP0004484_altered_response_of | 1.17448988 |
| 61 | MP0004085_abnormal_heartbeat | 1.15478931 |
| 62 | MP0004742_abnormal_vestibular_system | 1.15390176 |
| 63 | MP0003137_abnormal_impulse_conducting | 1.09033032 |
| 64 | MP0002138_abnormal_hepatobiliary_system | 1.08818569 |
| 65 | MP0001502_abnormal_circadian_rhythm | 1.07931625 |
| 66 | MP0003075_altered_response_to | 1.07856346 |
| 67 | MP0008874_decreased_physiological_sensi | 1.03026735 |
| 68 | MP0004036_abnormal_muscle_relaxation | 1.02627611 |
| 69 | MP0004084_abnormal_cardiac_muscle | 1.01663445 |
| 70 | MP0000604_amyloidosis | 1.01019048 |
| 71 | MP0003690_abnormal_glial_cell | 1.00773624 |
| 72 | MP0001348_abnormal_lacrimal_gland | 0.98329233 |
| 73 | MP0000749_muscle_degeneration | 0.97492091 |
| 74 | MP0002229_neurodegeneration | 0.96694431 |
| 75 | MP0005646_abnormal_pituitary_gland | 0.96674631 |
| 76 | MP0003632_abnormal_nervous_system | 0.93118308 |
| 77 | MP0002160_abnormal_reproductive_system | 0.92799141 |
| 78 | MP0005623_abnormal_meninges_morphology | 0.92299600 |
| 79 | MP0002152_abnormal_brain_morphology | 0.91955095 |
| 80 | MP0006276_abnormal_autonomic_nervous | 0.90878438 |
| 81 | MP0002332_abnormal_exercise_endurance | 0.90626974 |
| 82 | MP0001529_abnormal_vocalization | 0.88007312 |
| 83 | MP0008961_abnormal_basal_metabolism | 0.86107644 |
| 84 | MP0000747_muscle_weakness | 0.85641290 |
| 85 | MP0003634_abnormal_glial_cell | 0.85597160 |
| 86 | MP0001485_abnormal_pinna_reflex | 0.82803163 |
| 87 | MP0000013_abnormal_adipose_tissue | 0.81213316 |
| 88 | MP0005385_cardiovascular_system_phenoty | 0.80550388 |
| 89 | MP0001544_abnormal_cardiovascular_syste | 0.80550388 |
| 90 | MP0005671_abnormal_response_to | 0.79586628 |
| 91 | MP0003724_increased_susceptibility_to | 0.77184022 |
| 92 | MP0002972_abnormal_cardiac_muscle | 0.76793444 |
| 93 | MP0002127_abnormal_cardiovascular_syste | 0.76404640 |
| 94 | MP0003303_peritoneal_inflammation | 0.76313355 |
| 95 | MP0004130_abnormal_muscle_cell | 0.75936865 |
| 96 | MP0000230_abnormal_systemic_arterial | 0.75864439 |
| 97 | MP0005620_abnormal_muscle_contractility | 0.74509237 |
| 98 | MP0000631_abnormal_neuroendocrine_gland | 0.72539008 |
| 99 | MP0006036_abnormal_mitochondrial_physio | 0.72101099 |
| 100 | MP0005535_abnormal_body_temperature | 0.70859559 |
| 101 | MP0004087_abnormal_muscle_fiber | 0.70432259 |
| 102 | MP0003283_abnormal_digestive_organ | 0.70045377 |
| 103 | MP0001299_abnormal_eye_distance/ | 0.69922009 |
| 104 | MP0001963_abnormal_hearing_physiology | 0.69822533 |
| 105 | MP0005174_abnormal_tail_pigmentation | 0.68883008 |
| 106 | MP0001765_abnormal_ion_homeostasis | 0.68504858 |
| 107 | MP0003183_abnormal_peptide_metabolism | 0.66606709 |
| 108 | MP0002102_abnormal_ear_morphology | 0.66435650 |
| 109 | MP0008872_abnormal_physiological_respon | 0.66263562 |
| 110 | MP0002069_abnormal_eating/drinking_beha | 0.65930414 |
| 111 | MP0001177_atelectasis | 0.64941409 |
| 112 | MP0005330_cardiomyopathy | 0.62745893 |
| 113 | MP0003045_fibrosis | 0.62318608 |
| 114 | MP0004233_abnormal_muscle_weight | 0.61410812 |
| 115 | MP0002106_abnormal_muscle_physiology | 0.61177006 |
| 116 | MP0002752_abnormal_somatic_nervous | 0.60368303 |
| 117 | MP0005645_abnormal_hypothalamus_physiol | 0.59796230 |
| 118 | MP0002090_abnormal_vision | 0.58605318 |
| 119 | MP0008775_abnormal_heart_ventricle | 0.56640614 |
| 120 | MP0005551_abnormal_eye_electrophysiolog | 0.56069014 |
| 121 | MP0000759_abnormal_skeletal_muscle | 0.54805291 |
| 122 | MP0001943_abnormal_respiration | 0.52989840 |
| 123 | MP0010769_abnormal_survival | 0.52051929 |
| 124 | MP0005167_abnormal_blood-brain_barrier | 0.51618389 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.10578586 |
| 2 | Myokymia (HP:0002411) | 6.69434752 |
| 3 | Focal seizures (HP:0007359) | 5.43863534 |
| 4 | Visual hallucinations (HP:0002367) | 5.15592198 |
| 5 | Atonic seizures (HP:0010819) | 4.90135423 |
| 6 | Action tremor (HP:0002345) | 4.68705251 |
| 7 | Progressive cerebellar ataxia (HP:0002073) | 4.54072222 |
| 8 | Febrile seizures (HP:0002373) | 4.28281354 |
| 9 | Epileptic encephalopathy (HP:0200134) | 4.28177314 |
| 10 | Gaze-evoked nystagmus (HP:0000640) | 4.16443376 |
| 11 | Absence seizures (HP:0002121) | 3.96942107 |
| 12 | Dysmetric saccades (HP:0000641) | 3.87827395 |
| 13 | Broad-based gait (HP:0002136) | 3.70762511 |
| 14 | Dialeptic seizures (HP:0011146) | 3.68710808 |
| 15 | Dysmetria (HP:0001310) | 3.67606740 |
| 16 | Dysdiadochokinesis (HP:0002075) | 3.51587513 |
| 17 | Scanning speech (HP:0002168) | 3.36321963 |
| 18 | Clumsiness (HP:0002312) | 3.34704906 |
| 19 | Generalized tonic-clonic seizures (HP:0002069) | 3.34035382 |
| 20 | Supranuclear gaze palsy (HP:0000605) | 3.31145038 |
| 21 | Truncal ataxia (HP:0002078) | 3.25490284 |
| 22 | Ventricular fibrillation (HP:0001663) | 3.22049591 |
| 23 | Poor eye contact (HP:0000817) | 3.07131588 |
| 24 | Depression (HP:0000716) | 3.06889858 |
| 25 | Genetic anticipation (HP:0003743) | 3.06563064 |
| 26 | Bundle branch block (HP:0011710) | 3.04833329 |
| 27 | Impaired smooth pursuit (HP:0007772) | 3.03977226 |
| 28 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.03605272 |
| 29 | Papilledema (HP:0001085) | 3.01225148 |
| 30 | Intention tremor (HP:0002080) | 2.96699399 |
| 31 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.95528988 |
| 32 | Ankle clonus (HP:0011448) | 2.92691842 |
| 33 | Sudden death (HP:0001699) | 2.90133186 |
| 34 | Abnormal social behavior (HP:0012433) | 2.81512689 |
| 35 | Impaired social interactions (HP:0000735) | 2.81512689 |
| 36 | Limb dystonia (HP:0002451) | 2.80958094 |
| 37 | Diplopia (HP:0000651) | 2.77955815 |
| 38 | Abnormality of binocular vision (HP:0011514) | 2.77955815 |
| 39 | Hemiplegia (HP:0002301) | 2.77703046 |
| 40 | Urinary urgency (HP:0000012) | 2.77410854 |
| 41 | Anxiety (HP:0000739) | 2.76740157 |
| 42 | Annular pancreas (HP:0001734) | 2.67527714 |
| 43 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.60525460 |
| 44 | Postural instability (HP:0002172) | 2.58595550 |
| 45 | Abnormality of the lower motor neuron (HP:0002366) | 2.55737684 |
| 46 | Spastic gait (HP:0002064) | 2.53885901 |
| 47 | Hyporeflexia of lower limbs (HP:0002600) | 2.53327118 |
| 48 | Amblyopia (HP:0000646) | 2.52821519 |
| 49 | Progressive inability to walk (HP:0002505) | 2.51945246 |
| 50 | Termporal pattern (HP:0011008) | 2.49639986 |
| 51 | Insidious onset (HP:0003587) | 2.49639986 |
| 52 | Fetal akinesia sequence (HP:0001989) | 2.48831330 |
| 53 | Peripheral hypomyelination (HP:0007182) | 2.43334268 |
| 54 | Hyperventilation (HP:0002883) | 2.42089719 |
| 55 | Abnormal eating behavior (HP:0100738) | 2.41978786 |
| 56 | Stereotypic behavior (HP:0000733) | 2.38078424 |
| 57 | Atrial fibrillation (HP:0005110) | 2.37986778 |
| 58 | Primary atrial arrhythmia (HP:0001692) | 2.37032794 |
| 59 | Decreased circulating renin level (HP:0003351) | 2.34684264 |
| 60 | Prolonged QT interval (HP:0001657) | 2.32819452 |
| 61 | Mutism (HP:0002300) | 2.30067947 |
| 62 | Muscle fiber splitting (HP:0003555) | 2.26670265 |
| 63 | Abnormality of the corticospinal tract (HP:0002492) | 2.25918763 |
| 64 | Abnormality of saccadic eye movements (HP:0000570) | 2.24836047 |
| 65 | Syncope (HP:0001279) | 2.24751732 |
| 66 | Exercise-induced myalgia (HP:0003738) | 2.24077707 |
| 67 | Neurofibrillary tangles (HP:0002185) | 2.22950433 |
| 68 | Abnormal EKG (HP:0003115) | 2.22423757 |
| 69 | Abnormal drinking behavior (HP:0030082) | 2.22342839 |
| 70 | Polydipsia (HP:0001959) | 2.22342839 |
| 71 | Supraventricular tachycardia (HP:0004755) | 2.22327928 |
| 72 | Cerebral inclusion bodies (HP:0100314) | 2.20588888 |
| 73 | Lower limb asymmetry (HP:0100559) | 2.20371723 |
| 74 | Inability to walk (HP:0002540) | 2.20229474 |
| 75 | Ventricular arrhythmia (HP:0004308) | 2.19840651 |
| 76 | Impaired vibratory sensation (HP:0002495) | 2.19799963 |
| 77 | Rapidly progressive (HP:0003678) | 2.18981956 |
| 78 | Congenital stationary night blindness (HP:0007642) | 2.18900561 |
| 79 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.16906447 |
| 80 | Drooling (HP:0002307) | 2.15939653 |
| 81 | Excessive salivation (HP:0003781) | 2.15939653 |
| 82 | Supraventricular arrhythmia (HP:0005115) | 2.15357480 |
| 83 | Megalencephaly (HP:0001355) | 2.13834246 |
| 84 | Lower limb amyotrophy (HP:0007210) | 2.11894380 |
| 85 | Hemiparesis (HP:0001269) | 2.11850759 |
| 86 | Pheochromocytoma (HP:0002666) | 2.08290263 |
| 87 | Torticollis (HP:0000473) | 2.02111671 |
| 88 | Myotonia (HP:0002486) | 2.01218838 |
| 89 | Bradykinesia (HP:0002067) | 1.98307620 |
| 90 | Pointed chin (HP:0000307) | 1.97475907 |
| 91 | Obstructive sleep apnea (HP:0002870) | 1.96237330 |
| 92 | Agitation (HP:0000713) | 1.95129778 |
| 93 | Anomalous pulmonary venous return (HP:0010772) | 1.94480408 |
| 94 | Calf muscle hypertrophy (HP:0008981) | 1.93719170 |
| 95 | Lower limb muscle weakness (HP:0007340) | 1.92817036 |
| 96 | Vertebral arch anomaly (HP:0008438) | 1.91753930 |
| 97 | Onion bulb formation (HP:0003383) | 1.91399093 |
| 98 | Gait ataxia (HP:0002066) | 1.91117313 |
| 99 | Heart block (HP:0012722) | 1.90814630 |
| 100 | Absent speech (HP:0001344) | 1.90659185 |
| 101 | Cerebral hypomyelination (HP:0006808) | 1.90616521 |
| 102 | Incomplete penetrance (HP:0003829) | 1.90035245 |
| 103 | Fair hair (HP:0002286) | 1.89840326 |
| 104 | Focal dystonia (HP:0004373) | 1.89272023 |
| 105 | Abnormality of alanine metabolism (HP:0010916) | 1.89061459 |
| 106 | Hyperalaninemia (HP:0003348) | 1.89061459 |
| 107 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.89061459 |
| 108 | Status epilepticus (HP:0002133) | 1.88799143 |
| 109 | Abnormality of the calf musculature (HP:0001430) | 1.85350646 |
| 110 | Decreased central vision (HP:0007663) | 1.84380756 |
| 111 | Muscle hypertrophy of the lower extremities (HP:0008968) | 1.84200483 |
| 112 | Neuroendocrine neoplasm (HP:0100634) | 1.82645528 |
| 113 | Epileptiform EEG discharges (HP:0011182) | 1.82569943 |
| 114 | Tongue fasciculations (HP:0001308) | 1.82143905 |
| 115 | Generalized myoclonic seizures (HP:0002123) | 1.81725003 |
| 116 | Difficulty running (HP:0009046) | 1.80696314 |
| 117 | Polyphagia (HP:0002591) | 1.79322900 |
| 118 | Hammertoe (HP:0001765) | 1.79268210 |
| 119 | Sensory axonal neuropathy (HP:0003390) | 1.77873473 |
| 120 | Abnormal atrioventricular conduction (HP:0005150) | 1.76962394 |
| 121 | Muscle fibrillation (HP:0010546) | 1.74102955 |
| 122 | Congenital sensorineural hearing impairment (HP:0008527) | 1.74084007 |
| 123 | EEG with generalized epileptiform discharges (HP:0011198) | 1.70437365 |
| 124 | Frequent falls (HP:0002359) | 1.65957026 |
| 125 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.65736201 |
| 126 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.65736201 |
| 127 | Generalized hypopigmentation of hair (HP:0011358) | 1.65127520 |
| 128 | Slow saccadic eye movements (HP:0000514) | 1.64246784 |
| 129 | EMG: neuropathic changes (HP:0003445) | 1.63694411 |
| 130 | Abnormality of the pulmonary veins (HP:0011718) | 1.63304192 |
| 131 | Hypsarrhythmia (HP:0002521) | 1.61942658 |
| 132 | Palpitations (HP:0001962) | 1.60853177 |
| 133 | EMG: myopathic abnormalities (HP:0003458) | 1.60680620 |
| 134 | Renal cortical cysts (HP:0000803) | 1.60331279 |
| 135 | Metabolic alkalosis (HP:0200114) | 1.60224533 |
| 136 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.58962613 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.50041849 |
| 2 | EPHA4 | 3.89216420 |
| 3 | MAP3K9 | 3.45778371 |
| 4 | FRK | 3.30381872 |
| 5 | PAK6 | 2.60759514 |
| 6 | RIPK4 | 2.49042512 |
| 7 | MAP3K4 | 2.42948423 |
| 8 | DAPK2 | 2.29914080 |
| 9 | KSR2 | 2.28954122 |
| 10 | OBSCN | 2.28156198 |
| 11 | MINK1 | 2.25136764 |
| 12 | PRPF4B | 2.16194125 |
| 13 | TIE1 | 2.14576676 |
| 14 | TLK1 | 2.09508738 |
| 15 | CAMKK1 | 1.92366743 |
| 16 | CDK19 | 1.92063874 |
| 17 | TAOK3 | 1.89531751 |
| 18 | MAP2K7 | 1.87184904 |
| 19 | NTRK2 | 1.85184419 |
| 20 | PRKD3 | 1.81739261 |
| 21 | NTRK1 | 1.81301462 |
| 22 | MARK1 | 1.67238068 |
| 23 | BLK | 1.65268520 |
| 24 | CDK5 | 1.55467488 |
| 25 | MAP2K4 | 1.52592825 |
| 26 | FES | 1.51229163 |
| 27 | TNIK | 1.48825973 |
| 28 | STK38 | 1.48640429 |
| 29 | TAOK1 | 1.41980190 |
| 30 | CAMKK2 | 1.38024184 |
| 31 | ADRBK2 | 1.36604300 |
| 32 | GRK1 | 1.29627473 |
| 33 | GRK5 | 1.29186403 |
| 34 | MAP4K2 | 1.26528762 |
| 35 | MAP3K2 | 1.26327954 |
| 36 | TXK | 1.24397676 |
| 37 | MAP3K12 | 1.24137190 |
| 38 | OXSR1 | 1.22857799 |
| 39 | KSR1 | 1.20625456 |
| 40 | MAP3K13 | 1.19755537 |
| 41 | DAPK1 | 1.19638331 |
| 42 | ARAF | 1.18706814 |
| 43 | PRKCH | 1.18579794 |
| 44 | SIK2 | 1.16506562 |
| 45 | STK11 | 1.16184443 |
| 46 | TYRO3 | 1.15055813 |
| 47 | WNK1 | 1.14871498 |
| 48 | CAMK1 | 1.14309685 |
| 49 | RIPK1 | 1.14072080 |
| 50 | SYK | 1.12336479 |
| 51 | UHMK1 | 1.09310237 |
| 52 | PHKG2 | 1.06325199 |
| 53 | PHKG1 | 1.06325199 |
| 54 | PTK2B | 1.03654948 |
| 55 | RAF1 | 1.02921308 |
| 56 | PDK1 | 1.02008420 |
| 57 | MUSK | 1.00680130 |
| 58 | STK39 | 0.99375056 |
| 59 | PRKCG | 0.98278611 |
| 60 | RET | 0.98152511 |
| 61 | CAMK2A | 0.97843918 |
| 62 | MAP3K7 | 0.97329770 |
| 63 | DMPK | 0.96512469 |
| 64 | ALK | 0.94745035 |
| 65 | PDPK1 | 0.92077986 |
| 66 | BMPR1B | 0.90777015 |
| 67 | TEC | 0.90297287 |
| 68 | LMTK2 | 0.89416573 |
| 69 | PLK2 | 0.89380103 |
| 70 | CAMK2B | 0.89373246 |
| 71 | MARK2 | 0.87212750 |
| 72 | CAMK2D | 0.87035933 |
| 73 | PAK3 | 0.86987221 |
| 74 | PIK3CA | 0.86667143 |
| 75 | PNCK | 0.85929150 |
| 76 | TNK2 | 0.85772081 |
| 77 | SGK494 | 0.84528060 |
| 78 | SGK223 | 0.84528060 |
| 79 | MAPK13 | 0.84515933 |
| 80 | MAP3K1 | 0.81008752 |
| 81 | CASK | 0.80334916 |
| 82 | CDK15 | 0.79588311 |
| 83 | ITK | 0.79573090 |
| 84 | GRK7 | 0.78526025 |
| 85 | CDK18 | 0.77873067 |
| 86 | ROCK2 | 0.77361388 |
| 87 | SGK3 | 0.77148541 |
| 88 | CDK14 | 0.76029701 |
| 89 | SGK1 | 0.70491048 |
| 90 | NME1 | 0.69073467 |
| 91 | CDK11A | 0.68933974 |
| 92 | SGK2 | 0.68887126 |
| 93 | PDK2 | 0.67200452 |
| 94 | WNK4 | 0.63952508 |
| 95 | PRKACA | 0.61964566 |
| 96 | FYN | 0.61926876 |
| 97 | MAP2K6 | 0.61804783 |
| 98 | CAMK4 | 0.60872880 |
| 99 | PINK1 | 0.60828730 |
| 100 | BMPR2 | 0.60248753 |
| 101 | PRKD2 | 0.60139087 |
| 102 | ZAK | 0.59095261 |
| 103 | MAPK7 | 0.58231273 |
| 104 | NEK6 | 0.55214208 |
| 105 | TRIB3 | 0.54923847 |
| 106 | CAMK2G | 0.54533957 |
| 107 | MAPK4 | 0.54509106 |
| 108 | MAP2K1 | 0.52881588 |
| 109 | CAMK1G | 0.52658374 |
| 110 | PRKG1 | 0.51558253 |
| 111 | MAPKAPK5 | 0.51521873 |
| 112 | INSRR | 0.51394905 |
| 113 | MAPKAPK3 | 0.49808504 |
| 114 | TRPM7 | 0.49504432 |
| 115 | RPS6KA3 | 0.49205132 |
| 116 | PRKAA1 | 0.47715074 |
| 117 | PRKD1 | 0.46432518 |
| 118 | PRKCA | 0.45950649 |
| 119 | CDC42BPA | 0.44765936 |
| 120 | CSNK1G2 | 0.44432871 |
| 121 | FGR | 0.44001881 |
| 122 | CCNB1 | 0.42678492 |
| 123 | DYRK1A | 0.41754380 |
| 124 | ADRBK1 | 0.41653510 |
| 125 | MAPK10 | 0.40765704 |
| 126 | PKN1 | 0.40612613 |
| 127 | LATS2 | 0.40595337 |
| 128 | PRKCE | 0.40223896 |
| 129 | PRKCZ | 0.39621363 |
| 130 | PRKAA2 | 0.39154461 |
| 131 | DAPK3 | 0.38887561 |
| 132 | PRKCQ | 0.38770989 |
| 133 | MAPK12 | 0.37552808 |
| 134 | PRKACG | 0.36775457 |
| 135 | EPHB1 | 0.36589606 |
| 136 | BCKDK | 0.36094884 |
| 137 | IKBKB | 0.34973146 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.11046862 |
| 2 | Long-term potentiation_Homo sapiens_hsa04720 | 2.66426818 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.60873111 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.60128433 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.57949657 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.56708153 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.44259172 |
| 8 | GABAergic synapse_Homo sapiens_hsa04727 | 2.29094246 |
| 9 | Morphine addiction_Homo sapiens_hsa05032 | 2.27682284 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.15711349 |
| 11 | Salivary secretion_Homo sapiens_hsa04970 | 2.13917904 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.92400159 |
| 13 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.91736380 |
| 14 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.86775147 |
| 15 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.85661060 |
| 16 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.85241522 |
| 17 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.81004195 |
| 18 | Long-term depression_Homo sapiens_hsa04730 | 1.80402685 |
| 19 | Insulin secretion_Homo sapiens_hsa04911 | 1.72840406 |
| 20 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.72621047 |
| 21 | Phototransduction_Homo sapiens_hsa04744 | 1.68598861 |
| 22 | Taste transduction_Homo sapiens_hsa04742 | 1.65211718 |
| 23 | Renin secretion_Homo sapiens_hsa04924 | 1.57152023 |
| 24 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.56717789 |
| 25 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.51846319 |
| 26 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.44496590 |
| 27 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.42017472 |
| 28 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.40592907 |
| 29 | Cocaine addiction_Homo sapiens_hsa05030 | 1.38898537 |
| 30 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.37060637 |
| 31 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.34765182 |
| 32 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.26504641 |
| 33 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.26292541 |
| 34 | Gap junction_Homo sapiens_hsa04540 | 1.21596602 |
| 35 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.19179203 |
| 36 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.18334909 |
| 37 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.15105202 |
| 38 | Glioma_Homo sapiens_hsa05214 | 1.14508807 |
| 39 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.13615833 |
| 40 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.10298670 |
| 41 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.09947623 |
| 42 | Axon guidance_Homo sapiens_hsa04360 | 1.04813363 |
| 43 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.04282437 |
| 44 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.00762353 |
| 45 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.97186685 |
| 46 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.96998597 |
| 47 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.96842863 |
| 48 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.93276531 |
| 49 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.93243854 |
| 50 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.93134735 |
| 51 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.92107242 |
| 52 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.92014036 |
| 53 | Melanogenesis_Homo sapiens_hsa04916 | 0.89337498 |
| 54 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.88628874 |
| 55 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.88046078 |
| 56 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.85373284 |
| 57 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.83758722 |
| 58 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.82092050 |
| 59 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.80828286 |
| 60 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.79449613 |
| 61 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.77721988 |
| 62 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.77625830 |
| 63 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.75053080 |
| 64 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.74701836 |
| 65 | Bile secretion_Homo sapiens_hsa04976 | 0.73610567 |
| 66 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.72116179 |
| 67 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.71050546 |
| 68 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.69998687 |
| 69 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.69002187 |
| 70 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.67621972 |
| 71 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.67458156 |
| 72 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.67237318 |
| 73 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.65929998 |
| 74 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.65803949 |
| 75 | ABC transporters_Homo sapiens_hsa02010 | 0.65231366 |
| 76 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.65052344 |
| 77 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.64672567 |
| 78 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.64571283 |
| 79 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.64442881 |
| 80 | Endocytosis_Homo sapiens_hsa04144 | 0.63210222 |
| 81 | Parkinsons disease_Homo sapiens_hsa05012 | 0.62892798 |
| 82 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.62432738 |
| 83 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.61434217 |
| 84 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.61375338 |
| 85 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.60790240 |
| 86 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.60653676 |
| 87 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.60610230 |
| 88 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.58317034 |
| 89 | Platelet activation_Homo sapiens_hsa04611 | 0.58288047 |
| 90 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.57622513 |
| 91 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.54383911 |
| 92 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.53837512 |
| 93 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.52197478 |
| 94 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.49867549 |
| 95 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.49450786 |
| 96 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.47791754 |
| 97 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.46766851 |
| 98 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.46639562 |
| 99 | Asthma_Homo sapiens_hsa05310 | 0.45986987 |
| 100 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.45724045 |
| 101 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.45281993 |
| 102 | Circadian rhythm_Homo sapiens_hsa04710 | 0.44879212 |
| 103 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.43138591 |
| 104 | Mineral absorption_Homo sapiens_hsa04978 | 0.42158785 |
| 105 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.42152048 |
| 106 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.42085242 |
| 107 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.41541052 |
| 108 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.40922366 |
| 109 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.40099683 |
| 110 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.39930433 |
| 111 | Endometrial cancer_Homo sapiens_hsa05213 | 0.39862645 |
| 112 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.39598164 |
| 113 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.38233076 |
| 114 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.38058870 |
| 115 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.37982832 |
| 116 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.36632875 |
| 117 | Alzheimers disease_Homo sapiens_hsa05010 | 0.35949838 |
| 118 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.35731332 |
| 119 | Alcoholism_Homo sapiens_hsa05034 | 0.35683838 |
| 120 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.34300050 |
| 121 | Salmonella infection_Homo sapiens_hsa05132 | 0.33697837 |
| 122 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.33409284 |
| 123 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.32971688 |
| 124 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.32302041 |
| 125 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.32159536 |
| 126 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.32109674 |
| 127 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.27122070 |
| 128 | Insulin resistance_Homo sapiens_hsa04931 | 0.25297065 |

