GFPT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.64696596
2Golgi transport vesicle coating (GO:0048200)8.64696596
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.91631100
4COPII vesicle coating (GO:0048208)5.45522971
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.28601886
6* activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.09524128
7type B pancreatic cell development (GO:0003323)5.06584580
8protein retention in ER lumen (GO:0006621)5.02758424
9intestinal epithelial cell development (GO:0060576)4.95737034
10* positive regulation of nuclease activity (GO:0032075)4.80544756
11vesicle coating (GO:0006901)4.64864216
12columnar/cuboidal epithelial cell development (GO:0002066)4.49554310
13endocrine pancreas development (GO:0031018)4.46973145
14* regulation of nuclease activity (GO:0032069)4.33778948
15* endoplasmic reticulum unfolded protein response (GO:0030968)4.33425826
16glandular epithelial cell differentiation (GO:0002067)4.32089880
17glandular epithelial cell development (GO:0002068)4.27423959
18peptide hormone processing (GO:0016486)4.25791219
19exocrine pancreas development (GO:0031017)4.22642157
20* cellular response to unfolded protein (GO:0034620)4.19909282
21protein targeting to Golgi (GO:0000042)4.16790033
22intestinal absorption (GO:0050892)4.09208324
23* ER-nucleus signaling pathway (GO:0006984)4.05875316
24regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.89807375
25* cellular response to topologically incorrect protein (GO:0035967)3.88761733
26cellular response to vitamin D (GO:0071305)3.88442060
27establishment of protein localization to Golgi (GO:0072600)3.84484416
28ER overload response (GO:0006983)3.81812999
29ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.81726501
30protein maturation by protein folding (GO:0022417)3.80817437
31bundle of His cell to Purkinje myocyte communication (GO:0086069)3.66152646
32* response to endoplasmic reticulum stress (GO:0034976)3.66088239
33retrograde transport, vesicle recycling within Golgi (GO:0000301)3.65994412
34nuclear pore complex assembly (GO:0051292)3.57547509
35regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.52833659
36membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.49317439
37sequestering of metal ion (GO:0051238)3.48293574
38macroautophagy (GO:0016236)3.43407737
39positive regulation of hormone biosynthetic process (GO:0046886)3.42525736
40Golgi organization (GO:0007030)3.40552928
41intra-Golgi vesicle-mediated transport (GO:0006891)3.40529290
42intestinal cholesterol absorption (GO:0030299)3.34782833
43* UDP-N-acetylglucosamine metabolic process (GO:0006047)3.33417076
44desmosome organization (GO:0002934)3.33415912
45inner ear receptor cell development (GO:0060119)3.33028181
46insulin secretion (GO:0030073)3.24398171
47* response to unfolded protein (GO:0006986)3.24160032
48* peptidyl-asparagine modification (GO:0018196)3.23860572
49* protein N-linked glycosylation via asparagine (GO:0018279)3.22509972
50L-alpha-amino acid transmembrane transport (GO:1902475)3.20440570
51cell adhesion mediated by integrin (GO:0033627)3.18813473
52membrane repolarization during action potential (GO:0086011)3.15433273
53cytoplasmic mRNA processing body assembly (GO:0033962)3.12788555
54cellular response to vitamin (GO:0071295)3.10137782
55nuclear pore organization (GO:0006999)3.09199867
56endoplasmic reticulum organization (GO:0007029)3.07632515
57* response to topologically incorrect protein (GO:0035966)3.02802883
58regulation of type B pancreatic cell apoptotic process (GO:2000674)2.97548503
59cell migration involved in gastrulation (GO:0042074)2.96292243
60* protein N-linked glycosylation (GO:0006487)2.93032913
61insulin-like growth factor receptor signaling pathway (GO:0048009)2.93017834
62transcytosis (GO:0045056)2.92855539
63cellular response to hepatocyte growth factor stimulus (GO:0035729)2.89363179
64response to hepatocyte growth factor (GO:0035728)2.89363179
654-hydroxyproline metabolic process (GO:0019471)2.83754121
66cerebellar Purkinje cell layer development (GO:0021680)2.83216821
67positive regulation of insulin secretion (GO:0032024)2.81352503
68protein localization to Golgi apparatus (GO:0034067)2.80152062
69N-glycan processing (GO:0006491)2.77790914
70smooth muscle tissue development (GO:0048745)2.76619187
71growth hormone receptor signaling pathway (GO:0060396)2.75213040
72ER to Golgi vesicle-mediated transport (GO:0006888)2.75128286
73paraxial mesoderm development (GO:0048339)2.73057675
74embryonic foregut morphogenesis (GO:0048617)2.72970626
75positive regulation of glycoprotein metabolic process (GO:1903020)2.69094866
76dorsal/ventral axis specification (GO:0009950)2.68598605
77regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.66101967
78peptide secretion (GO:0002790)2.65657624
79cytoskeletal anchoring at plasma membrane (GO:0007016)2.65090581
80anterior/posterior axis specification, embryo (GO:0008595)2.64932521
81relaxation of cardiac muscle (GO:0055119)2.64280325
82regulation of cell fate specification (GO:0042659)2.64080522
83regulation of Golgi to plasma membrane protein transport (GO:0042996)2.63788501
84positive regulation of histone deacetylation (GO:0031065)2.60818496
85positive regulation of glycoprotein biosynthetic process (GO:0010560)2.58993442
86* nucleotide-sugar biosynthetic process (GO:0009226)2.58078318
87regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57687713
88regulation of insulin secretion (GO:0050796)2.57322378
89epithelial cell maturation (GO:0002070)2.56292252
90lipid translocation (GO:0034204)2.56096042
91phospholipid translocation (GO:0045332)2.56096042
92signal transduction involved in regulation of gene expression (GO:0023019)2.55955658
93kidney morphogenesis (GO:0060993)2.55651807
94branching involved in prostate gland morphogenesis (GO:0060442)2.54994191
95peptide hormone secretion (GO:0030072)2.54475314
96endocardial cushion development (GO:0003197)2.50912975
97tight junction assembly (GO:0070830)2.48703571
98positive regulation of steroid biosynthetic process (GO:0010893)2.48491244
99negative regulation of hormone biosynthetic process (GO:0032353)2.48165051
100negative regulation of hormone metabolic process (GO:0032351)2.48165051
101lung secretory cell differentiation (GO:0061140)2.46341198
102chondrocyte proliferation (GO:0035988)2.43549972
103digestive system process (GO:0022600)2.43296567
104endothelial cell morphogenesis (GO:0001886)2.41727279
105toxin metabolic process (GO:0009404)2.41651341
106Golgi vesicle transport (GO:0048193)2.40726615
107positive regulation of endothelial cell apoptotic process (GO:2000353)2.39452679
108positive regulation of glycolytic process (GO:0045821)2.38840757
109positive regulation of protein autophosphorylation (GO:0031954)2.38820943
110cell migration involved in sprouting angiogenesis (GO:0002042)2.38315454
111mesodermal cell differentiation (GO:0048333)2.36581634
112cellular response to growth hormone stimulus (GO:0071378)2.36344279
113negative regulation of cell fate specification (GO:0009996)2.35684391
114L-serine transport (GO:0015825)2.35597682
115maintenance of gastrointestinal epithelium (GO:0030277)2.35221478
116regulation of ARF protein signal transduction (GO:0032012)2.34438497
117negative regulation of keratinocyte proliferation (GO:0010839)2.33954121
118regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33540403
119establishment of apical/basal cell polarity (GO:0035089)2.33496515
120embryonic retina morphogenesis in camera-type eye (GO:0060059)2.33352149
121positive regulation of p38MAPK cascade (GO:1900745)2.32640072
122angiotensin maturation (GO:0002003)2.32615346
123regulation of transforming growth factor beta2 production (GO:0032909)2.32588477
124peptide transport (GO:0015833)2.32040699
125positive regulation of glycogen biosynthetic process (GO:0045725)2.31748246
126positive regulation of peptide hormone secretion (GO:0090277)2.31628139
127regulation of peptide hormone secretion (GO:0090276)2.31076064
128regulation of hormone biosynthetic process (GO:0046885)2.31004090
129regulation of cardioblast differentiation (GO:0051890)2.30946547
130epithelial cell fate commitment (GO:0072148)2.30881604
131magnesium ion transport (GO:0015693)2.30736754
132regulation of growth hormone secretion (GO:0060123)2.30043917
133O-glycan processing (GO:0016266)2.29439879
134regulation of glucose import in response to insulin stimulus (GO:2001273)2.29145348
135negative regulation of bone resorption (GO:0045779)2.28857988
136very-low-density lipoprotein particle assembly (GO:0034379)2.28827248
137gap junction assembly (GO:0016264)2.27810940
138positive regulation of catenin import into nucleus (GO:0035413)2.27736945
139growth hormone secretion (GO:0030252)2.27493709
140regulation of mesoderm development (GO:2000380)2.26407204
141retina vasculature morphogenesis in camera-type eye (GO:0061299)2.26233357
142lactate metabolic process (GO:0006089)2.22249540
143regulation of cholesterol homeostasis (GO:2000188)2.22093789
144cellular zinc ion homeostasis (GO:0006882)2.20887476
145midgut development (GO:0007494)2.19793096
146pore complex assembly (GO:0046931)2.19124006
147regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.18600156
148cellular glucuronidation (GO:0052695)2.17838670
149sequestering of extracellular ligand from receptor (GO:0035581)2.16645505
150hemidesmosome assembly (GO:0031581)2.15717461
151positive regulation of dendritic spine morphogenesis (GO:0061003)2.14832765
152positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.14612375
153regulation of metalloenzyme activity (GO:0048552)2.09912049
154glomerular visceral epithelial cell development (GO:0072015)2.08402023
155collagen fibril organization (GO:0030199)2.07754898
156skin morphogenesis (GO:0043589)2.06291938
157regulation of non-canonical Wnt signaling pathway (GO:2000050)2.06192307
158regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.04640051
159artery development (GO:0060840)2.04229798
160mitotic sister chromatid cohesion (GO:0007064)2.04047574
161glomerular epithelial cell development (GO:0072310)2.03584580
162regulation of bile acid biosynthetic process (GO:0070857)2.03504602
163gastrulation with mouth forming second (GO:0001702)2.02666043
164biotin metabolic process (GO:0006768)2.02319880
165polarized epithelial cell differentiation (GO:0030859)2.01554007
166response to follicle-stimulating hormone (GO:0032354)2.01537743
167Leydig cell differentiation (GO:0033327)2.00791410
168glucuronate metabolic process (GO:0019585)1.99636905
169uronic acid metabolic process (GO:0006063)1.99636905
170membrane budding (GO:0006900)1.98520108
171establishment of monopolar cell polarity (GO:0061162)1.98152977
172establishment or maintenance of monopolar cell polarity (GO:0061339)1.98152977
173homocysteine metabolic process (GO:0050667)1.97462412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.89362597
2STAT6_21828071_ChIP-Seq_BEAS2B_Human2.90160923
3GATA1_22025678_ChIP-Seq_K562_Human2.70231772
4AR_21909140_ChIP-Seq_LNCAP_Human2.65072529
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.54187701
6* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.45785743
7ZNF217_24962896_ChIP-Seq_MCF-7_Human2.36715796
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.28557290
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22112215
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15406734
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13016744
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06273802
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96844900
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.90660640
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.88464632
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84416408
17ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81522604
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.77003991
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.74238707
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.73671865
21SOX2_20726797_ChIP-Seq_SW620_Human1.65639273
22CLOCK_20551151_ChIP-Seq_293T_Human1.64764167
23FUS_26573619_Chip-Seq_HEK293_Human1.61135451
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.59088668
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58789475
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.55955958
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55037730
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54314685
29AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.54158216
30GATA6_25053715_ChIP-Seq_YYC3_Human1.53918643
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53113228
32TP53_18474530_ChIP-ChIP_U2OS_Human1.49645455
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.48461037
34AHR_22903824_ChIP-Seq_MCF-7_Human1.48123502
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45619580
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.44782791
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.44407510
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.43782518
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42790104
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42042777
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41958593
42GATA4_25053715_ChIP-Seq_YYC3_Human1.41940637
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41655404
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.40563065
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39937039
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36740211
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36182330
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35923974
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35067536
50GBX2_23144817_ChIP-Seq_PC3_Human1.34540019
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.34410206
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33798375
53E2F7_22180533_ChIP-Seq_HELA_Human1.33518735
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33362379
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32812500
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32365149
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31283204
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30461813
59ZNF274_21170338_ChIP-Seq_K562_Hela1.30304115
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30092033
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.29353672
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.29154521
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29060382
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28273973
65* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27840193
66PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25857611
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25248617
68* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24598070
69ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24053143
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23373395
71* P300_19829295_ChIP-Seq_ESCs_Human1.22768143
72FOXA1_25552417_ChIP-Seq_VCAP_Human1.21184079
73* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20801262
74* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.20059039
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19780701
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.19298946
77* SMAD4_21799915_ChIP-Seq_A2780_Human1.18666328
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18088625
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17737111
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.17012369
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15912620
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.14372995
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.13773668
84FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13272296
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13025797
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12353810
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.12250554
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11365160
89RXR_22108803_ChIP-Seq_LS180_Human1.11108832
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10613269
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09977218
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09231831
93DROSHA_22980978_ChIP-Seq_HELA_Human1.09042645
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08924532
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.08880027
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.08426071
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08122217
98EWS_26573619_Chip-Seq_HEK293_Human1.07902161
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.07893087
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.07776727
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07554294
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.06312241
103* KDM2B_26808549_Chip-Seq_K562_Human1.06029980
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05423648
105EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05270096
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.04851591
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04528091
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.04464500
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03819031
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03339230
111ZNF263_19887448_ChIP-Seq_K562_Human1.02993219
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02306325
113GATA3_24758297_ChIP-Seq_MCF-7_Human1.01676165
114CREB1_26743006_Chip-Seq_LNCaP_Human1.01672334
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01511407
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01086613
117* TP63_23658742_ChIP-Seq_EP156T_Human1.00805230
118STAT3_23295773_ChIP-Seq_U87_Human1.00793761
119CJUN_26792858_Chip-Seq_BT549_Human1.00482860
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99235651
121GATA1_19941826_ChIP-Seq_K562_Human0.99193346
122CDX2_22108803_ChIP-Seq_LS180_Human0.98676642
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98491073
124BCAT_22108803_ChIP-Seq_LS180_Human0.98381852
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97203901
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96910224
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.96757566
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96640757
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96640757
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96460630
131CHD1_26751641_Chip-Seq_LNCaP_Human0.95655166
132TCF4_23295773_ChIP-Seq_U87_Human0.95564060
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.95376571
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94403588
135KLF5_25053715_ChIP-Seq_YYC3_Human0.94083717
136EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94067680
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93862316
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92693014
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92693014
140AR_19668381_ChIP-Seq_PC3_Human0.91524330
141* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91491854
142TP53_16413492_ChIP-PET_HCT116_Human0.89018812
143* BRD4_25478319_ChIP-Seq_HGPS_Human0.87696866
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.87447858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.51156780
2MP0003283_abnormal_digestive_organ4.27455715
3MP0010234_abnormal_vibrissa_follicle4.15630023
4MP0009780_abnormal_chondrocyte_physiolo4.07020579
5MP0002909_abnormal_adrenal_gland3.85650122
6MP0004264_abnormal_extraembryonic_tissu3.71399014
7MP0003300_gastrointestinal_ulcer3.33992219
8MP0003941_abnormal_skin_development3.00251980
9MP0002693_abnormal_pancreas_physiology2.93988600
10MP0004043_abnormal_pH_regulation2.91334796
11MP0001944_abnormal_pancreas_morphology2.76237223
12MP0006054_spinal_hemorrhage2.65758969
13MP0000013_abnormal_adipose_tissue2.62174728
14MP0003183_abnormal_peptide_metabolism2.52927941
15MP0000462_abnormal_digestive_system2.39055716
16MP0002896_abnormal_bone_mineralization2.25667735
17MP0002139_abnormal_hepatobiliary_system2.17364989
18MP0000678_abnormal_parathyroid_gland2.14379543
19MP0010352_gastrointestinal_tract_polyps2.04253585
20MP0005076_abnormal_cell_differentiation2.04055553
21MP0010386_abnormal_urinary_bladder2.02336898
22MP0001666_abnormal_nutrient_absorption2.01782356
23MP0003045_fibrosis1.99027514
24MP0005220_abnormal_exocrine_pancreas1.96056997
25MP0005379_endocrine/exocrine_gland_phen1.95299101
26MP0000537_abnormal_urethra_morphology1.91984614
27MP0005310_abnormal_salivary_gland1.90866912
28MP0003937_abnormal_limbs/digits/tail_de1.79949354
29MP0001765_abnormal_ion_homeostasis1.77085537
30MP0002234_abnormal_pharynx_morphology1.76809017
31MP0003866_abnormal_defecation1.74650941
32MP0003868_abnormal_feces_composition1.72440214
33MP0003252_abnormal_bile_duct1.71911668
34MP0000569_abnormal_digit_pigmentation1.71605616
35MP0003567_abnormal_fetal_cardiomyocyte1.71188382
36MP0003705_abnormal_hypodermis_morpholog1.70745802
37MP0000003_abnormal_adipose_tissue1.67882022
38MP0003950_abnormal_plasma_membrane1.65182164
39MP0005187_abnormal_penis_morphology1.62499484
40MP0008961_abnormal_basal_metabolism1.60043434
41MP0000613_abnormal_salivary_gland1.56599525
42MP0000383_abnormal_hair_follicle1.51390676
43MP0002078_abnormal_glucose_homeostasis1.49591308
44MP0005257_abnormal_intraocular_pressure1.45381244
45MP0002009_preneoplasia1.43596587
46MP0001299_abnormal_eye_distance/1.42791962
47MP0003195_calcinosis1.38940479
48MP0005248_abnormal_Harderian_gland1.34713604
49MP0004782_abnormal_surfactant_physiolog1.33044059
50MP0005503_abnormal_tendon_morphology1.32038728
51MP0000516_abnormal_urinary_system1.31255392
52MP0005367_renal/urinary_system_phenotyp1.31255392
53MP0005360_urolithiasis1.28444519
54MP0002084_abnormal_developmental_patter1.27322243
55MP0003122_maternal_imprinting1.26452097
56MP0000566_synostosis1.26324415
57MP0002254_reproductive_system_inflammat1.21575823
58MP0003693_abnormal_embryo_hatching1.21183168
59MP0004957_abnormal_blastocyst_morpholog1.20813758
60MP0002160_abnormal_reproductive_system1.13802374
61MP0003942_abnormal_urinary_system1.13713027
62MP0005409_darkened_coat_color1.12772231
63MP0004185_abnormal_adipocyte_glucose1.09845638
64MP0000538_abnormal_urinary_bladder1.08158427
65MP0003172_abnormal_lysosome_physiology1.07693819
66MP0002166_altered_tumor_susceptibility1.07045820
67MP0003718_maternal_effect1.06434248
68MP0001849_ear_inflammation1.06035542
69MP0002928_abnormal_bile_duct1.05757423
70MP0005085_abnormal_gallbladder_physiolo1.05746152
71MP0001270_distended_abdomen1.04583144
72MP0002060_abnormal_skin_morphology1.03312316
73MP0004019_abnormal_vitamin_homeostasis1.03176703
74MP0002697_abnormal_eye_size1.01099673
75MP0001664_abnormal_digestion0.99869682
76MP0002138_abnormal_hepatobiliary_system0.99304078
77MP0005365_abnormal_bile_salt0.99273332
78MP0009697_abnormal_copulation0.98633947
79MP0003566_abnormal_cell_adhesion0.98184403
80MP0009643_abnormal_urine_homeostasis0.95738597
81MP0001756_abnormal_urination0.95265314
82MP0005381_digestive/alimentary_phenotyp0.95163035
83MP0004270_analgesia0.94396987
84MP0002086_abnormal_extraembryonic_tissu0.93983240
85MP0009384_cardiac_valve_regurgitation0.93899444
86MP0000432_abnormal_head_morphology0.92738666
87MP0003953_abnormal_hormone_level0.92600314
88MP0005623_abnormal_meninges_morphology0.92375815
89MP0000467_abnormal_esophagus_morphology0.92072200
90MP0005375_adipose_tissue_phenotype0.91852355
91MP0002085_abnormal_embryonic_tissue0.90084805
92MP0003119_abnormal_digestive_system0.89731667
93MP0001672_abnormal_embryogenesis/_devel0.89697182
94MP0005380_embryogenesis_phenotype0.89697182
95MP0002938_white_spotting0.89328802
96MP0003385_abnormal_body_wall0.88253486
97MP0000762_abnormal_tongue_morphology0.87940289
98MP0005058_abnormal_lysosome_morphology0.87411400
99MP0000647_abnormal_sebaceous_gland0.86202241
100MP0005332_abnormal_amino_acid0.85956970
101MP0001730_embryonic_growth_arrest0.85354885
102MP0008932_abnormal_embryonic_tissue0.85057357
103MP0003984_embryonic_growth_retardation0.84655177
104MP0000377_abnormal_hair_follicle0.83756973
105MP0004197_abnormal_fetal_growth/weight/0.82843223
106MP0000627_abnormal_mammary_gland0.82758877
107MP0002088_abnormal_embryonic_growth/wei0.82286663
108MP0008438_abnormal_cutaneous_collagen0.82011162
109MP0001697_abnormal_embryo_size0.81902751
110MP0003755_abnormal_palate_morphology0.81272950
111MP0003115_abnormal_respiratory_system0.79237249
112MP0000428_abnormal_craniofacial_morphol0.78496805
113MP0004272_abnormal_basement_membrane0.77246536
114MP0001873_stomach_inflammation0.76950519
115MP0001286_abnormal_eye_development0.76287275
116MP0002295_abnormal_pulmonary_circulatio0.76233822
117MP0010155_abnormal_intestine_physiology0.75898884
118MP0002168_other_aberrant_phenotype0.75755882
119MP0002233_abnormal_nose_morphology0.75655386
120MP0002098_abnormal_vibrissa_morphology0.74998642
121MP0002876_abnormal_thyroid_physiology0.74669719
122MP0006072_abnormal_retinal_apoptosis0.74526034
123MP0010307_abnormal_tumor_latency0.74519016
124MP0000163_abnormal_cartilage_morphology0.74379237
125MP0000477_abnormal_intestine_morphology0.74230372
126MP0003959_abnormal_lean_body0.73265610
127MP0003123_paternal_imprinting0.73259686
128MP0003936_abnormal_reproductive_system0.73087558
129MP0010678_abnormal_skin_adnexa0.72305790
130MP0000427_abnormal_hair_cycle0.72130422
131MP0001346_abnormal_lacrimal_gland0.71847809
132MP0000470_abnormal_stomach_morphology0.71845707
133MP0000681_abnormal_thyroid_gland0.70836268
134MP0005275_abnormal_skin_tensile0.70286125
135MP0003795_abnormal_bone_structure0.70233504
136MP0005448_abnormal_energy_balance0.70051499
137MP0001661_extended_life_span0.69712779
138MP0001293_anophthalmia0.69161011
139MP0002108_abnormal_muscle_morphology0.67532377
140MP0008775_abnormal_heart_ventricle0.67403069
141MP0010329_abnormal_lipoprotein_level0.66611465
142MP0003091_abnormal_cell_migration0.66506609
143MP0000534_abnormal_ureter_morphology0.65514608
144MP0005408_hypopigmentation0.64215964
145MP0009703_decreased_birth_body0.64136863
146MP0002006_tumorigenesis0.62275897
147MP0004858_abnormal_nervous_system0.60141572
148MP0002837_dystrophic_cardiac_calcinosis0.60062750
149MP0001881_abnormal_mammary_gland0.60006879
150MP0005636_abnormal_mineral_homeostasis0.59757002
151MP0001663_abnormal_digestive_system0.59623923
152MP0001348_abnormal_lacrimal_gland0.56616067
153MP0003890_abnormal_embryonic-extraembry0.56143618
154MP0002115_abnormal_skeleton_extremities0.55210559
155MP0005334_abnormal_fat_pad0.53357098
156MP0005666_abnormal_adipose_tissue0.52392548
157MP0003935_abnormal_craniofacial_develop0.52147340
158MP0004947_skin_inflammation0.51150935

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.29646011
2Hyperinsulinemic hypoglycemia (HP:0000825)4.91515195
3Hypoglycemic seizures (HP:0002173)4.20216877
4Insulin-resistant diabetes mellitus (HP:0000831)4.19622108
5Symptomatic seizures (HP:0011145)3.99657162
6Hyperglycemia (HP:0003074)3.85514589
7Premature rupture of membranes (HP:0001788)3.49393710
8Urinary glycosaminoglycan excretion (HP:0003541)3.43863702
9Mucopolysacchariduria (HP:0008155)3.43863702
10Hypoglycemic coma (HP:0001325)3.33620811
11Abnormality of endocrine pancreas physiology (HP:0012093)3.20242070
12Abnormality of the pancreatic islet cells (HP:0006476)3.20242070
13Abnormality of glycosaminoglycan metabolism (HP:0004371)3.10965684
14Abnormality of mucopolysaccharide metabolism (HP:0011020)3.10965684
15Abnormality of polysaccharide metabolism (HP:0011012)3.10965684
16Pancreatic islet-cell hyperplasia (HP:0004510)3.04682258
17Abnormal pancreas size (HP:0012094)3.01629969
18Abdominal distention (HP:0003270)2.95869965
19Agitation (HP:0000713)2.95715583
20Abnormality of calcium-phosphate metabolism (HP:0100530)2.91974098
21Thoracolumbar scoliosis (HP:0002944)2.75910400
22Intrahepatic cholestasis (HP:0001406)2.75259607
23Decreased circulating renin level (HP:0003351)2.75170795
24Dysostosis multiplex (HP:0000943)2.74847813
25Subacute progressive viral hepatitis (HP:0006572)2.74700014
26Large for gestational age (HP:0001520)2.72347441
27Papilledema (HP:0001085)2.68872500
28Hyperparathyroidism (HP:0000843)2.68687198
29Macroorchidism (HP:0000053)2.66403796
30Conjugated hyperbilirubinemia (HP:0002908)2.64601030
31Hypokalemia (HP:0002900)2.60827946
32Ketoacidosis (HP:0001993)2.56117894
33Abnormality of vitamin metabolism (HP:0100508)2.52932362
34Abnormality of the proximal phalanges of the hand (HP:0009834)2.49866204
35Severe short stature (HP:0003510)2.49590196
36Proximal tubulopathy (HP:0000114)2.43284512
37Protrusio acetabuli (HP:0003179)2.43060536
38Cardiovascular calcification (HP:0011915)2.42226469
39Abnormality of the nasal septum (HP:0000419)2.41170098
40Flat acetabular roof (HP:0003180)2.39363535
41Hyperactive renin-angiotensin system (HP:0000841)2.36282177
42Exocrine pancreatic insufficiency (HP:0001738)2.35004586
43Unilateral renal agenesis (HP:0000122)2.34629373
44Osteomalacia (HP:0002749)2.33386677
45Abnormality of chloride homeostasis (HP:0011422)2.33278473
46Abnormality of dentin (HP:0010299)2.29975642
47Late onset (HP:0003584)2.27505184
48Abnormality of renin-angiotensin system (HP:0000847)2.25570781
49Vascular calcification (HP:0004934)2.25339308
50Protuberant abdomen (HP:0001538)2.23909616
51Micronodular cirrhosis (HP:0001413)2.22805684
52Congenital glaucoma (HP:0001087)2.22264682
53Cervical subluxation (HP:0003308)2.22150643
54Abnormality of potassium homeostasis (HP:0011042)2.21941460
55Epidermoid cyst (HP:0200040)2.21782914
56Hypobetalipoproteinemia (HP:0003563)2.18924576
57Rectal prolapse (HP:0002035)2.17890715
58Aneurysm (HP:0002617)2.17664590
59Hyperphosphatemia (HP:0002905)2.17301099
60Insulin resistance (HP:0000855)2.16563287
61Asymmetry of the thorax (HP:0001555)2.15954799
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.15596977
63Cerebral aneurysm (HP:0004944)2.15520036
64Thyroid carcinoma (HP:0002890)2.15349837
65Abnormality of the intrinsic pathway (HP:0010989)2.14778472
66Retinal atrophy (HP:0001105)2.14632766
67Right ventricular cardiomyopathy (HP:0011663)2.12065997
68Fat malabsorption (HP:0002630)2.11647653
69Hypoplasia of the uterus (HP:0000013)2.11641217
70Aortic dissection (HP:0002647)2.11323585
71Curly hair (HP:0002212)2.11073971
72Tetraparesis (HP:0002273)2.09979199
73Villous atrophy (HP:0011473)2.09786061
74Abnormality of small intestinal villus morphology (HP:0011472)2.09786061
75Follicular hyperkeratosis (HP:0007502)2.08180332
76Abnormal foot bone ossification (HP:0010675)2.07446877
77Neonatal short-limb short stature (HP:0008921)2.06729307
78Arterial tortuosity (HP:0005116)2.06160520
79Hypoplastic ischia (HP:0003175)2.04122969
80Epiphyseal dysplasia (HP:0002656)2.03867126
81Thin bony cortex (HP:0002753)1.99585639
82Abnormal tarsal ossification (HP:0008369)1.98463957
83Soft skin (HP:0000977)1.95703989
84Abnormal biliary tract morphology (HP:0012440)1.95438589
85Hypoplastic labia majora (HP:0000059)1.93184162
86Spinal cord compression (HP:0002176)1.93066962
87Vascular tortuosity (HP:0004948)1.92110758
88Exostoses (HP:0100777)1.91557258
89Aortic aneurysm (HP:0004942)1.90470487
90Atrophic scars (HP:0001075)1.88670184
91Abnormality of the ischium (HP:0003174)1.88574980
92Abnormal cartilage morphology (HP:0002763)1.88454111
93Papillary thyroid carcinoma (HP:0002895)1.88371954
94Hand muscle atrophy (HP:0009130)1.87351569
95Abnormality of the gastric mucosa (HP:0004295)1.86208524
96Abnormality of the middle phalanges of the toes (HP:0010183)1.85530429
97Cortical dysplasia (HP:0002539)1.85073258
98Hypercortisolism (HP:0001578)1.84057944
99Hyperkalemia (HP:0002153)1.82549352
100Bronchomalacia (HP:0002780)1.80422303
101Hydroxyprolinuria (HP:0003080)1.80139278
102Abnormality of proline metabolism (HP:0010907)1.80139278
103Pterygium (HP:0001059)1.79208775
104Abnormality of vitamin B metabolism (HP:0004340)1.77274020
105Ankyloglossia (HP:0010296)1.74156209
106Hypolipoproteinemia (HP:0010981)1.73900324
107Abnormal delivery (HP:0001787)1.73467202
108Long toe (HP:0010511)1.72486668
109Fragile skin (HP:0001030)1.72292774
110Short humerus (HP:0005792)1.72193587
111Hypsarrhythmia (HP:0002521)1.71832553
112Abnormality of the labia majora (HP:0012881)1.69977637
113EEG with generalized epileptiform discharges (HP:0011198)1.69036090
114Hepatoblastoma (HP:0002884)1.68504102
115Abnormality of the common coagulation pathway (HP:0010990)1.67215381
116Restlessness (HP:0000711)1.65675780
117Progressive sensorineural hearing impairment (HP:0000408)1.63779117
118Bladder diverticulum (HP:0000015)1.62729721
119Focal segmental glomerulosclerosis (HP:0000097)1.62113896
120Enlarged penis (HP:0000040)1.61642711
121Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.61432479
122Coarse hair (HP:0002208)1.60236340
123Uterine neoplasm (HP:0010784)1.59925979
124Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59727446
125Hypercholesterolemia (HP:0003124)1.59103838
126Breech presentation (HP:0001623)1.58378367
127Buphthalmos (HP:0000557)1.58127175
128Neoplasm of the heart (HP:0100544)1.57813418
129Upper limb muscle weakness (HP:0003484)1.56729320
130Flattened epiphyses (HP:0003071)1.56042853
131Epileptiform EEG discharges (HP:0011182)1.55999539
132Relative macrocephaly (HP:0004482)1.55899203
133Skin nodule (HP:0200036)1.55889206
134Aplasia/hypoplasia of the uterus (HP:0008684)1.54959985
135Bundle branch block (HP:0011710)1.54867874
136Short hallux (HP:0010109)1.54570362
137Glucose intolerance (HP:0000833)1.54194266
138Neoplasm of the thyroid gland (HP:0100031)1.53851047
139Rhabdomyosarcoma (HP:0002859)1.53433525
140Breast carcinoma (HP:0003002)1.53054121
141Abnormality of carpal bone ossification (HP:0006257)1.52982110
142Neoplasm of the small intestine (HP:0100833)1.52355839
143Small epiphyses (HP:0010585)1.52053720
144Lip pit (HP:0100267)1.51669477
145Angiofibromas (HP:0010615)1.51473930
146Adenoma sebaceum (HP:0009720)1.51473930
147Hamartoma of the eye (HP:0010568)1.49938485
148Chronic diarrhea (HP:0002028)1.49382997
149Cupped ribs (HP:0000887)1.49004438
150Progressive hearing impairment (HP:0001730)1.48585767
151Bowel diverticulosis (HP:0005222)1.48501156
152Ependymoma (HP:0002888)1.48229194
153Hypoplasia of dental enamel (HP:0006297)1.48174414
154Enlarged epiphyses (HP:0010580)1.47941198
155Male infertility (HP:0003251)1.47906394
156Aplasia involving bones of the extremities (HP:0009825)1.47671469
157Aplasia involving bones of the upper limbs (HP:0009823)1.47671469
158Aplasia of the phalanges of the hand (HP:0009802)1.47671469
159Abnormality of the 1st metacarpal (HP:0010009)1.47445091
160Biliary tract neoplasm (HP:0100574)1.47151396
161Ovarian neoplasm (HP:0100615)1.47048804
162Abnormal glucose tolerance (HP:0001952)1.47017850
163Abnormality of the vitamin B12 metabolism (HP:0004341)1.46815946
164Sparse lateral eyebrow (HP:0005338)1.46626724
165Aplasia/hypoplasia of the humerus (HP:0006507)1.46621578
166Disproportionate short-trunk short stature (HP:0003521)1.46564571
167Hyperacusis (HP:0010780)1.46510130
168Hypotension (HP:0002615)1.45907113
169Multiple enchondromatosis (HP:0005701)1.45852908
170Overgrowth (HP:0001548)1.45161718
171Fibular aplasia (HP:0002990)1.43645416
172Chronic bronchitis (HP:0004469)1.43346469
173Hyperextensible skin (HP:0000974)1.43029312
174Abnormality of the acetabulum (HP:0003170)1.42426570
175Absent eyebrow (HP:0002223)1.42310908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.72143216
2FRK4.71537421
3INSRR4.17718103
4LATS13.08926504
5MAP3K22.76129100
6STK38L2.64577925
7ERN12.53938103
8SCYL22.49821346
9TRIM282.48651862
10PASK2.46989441
11BCR2.33833621
12PTK62.26916250
13PRKD32.25915917
14PDGFRA2.22676634
15EIF2AK32.20186492
16TRIB32.18731802
17CASK1.93784944
18TTK1.93002574
19AKT31.92060996
20RIPK11.85593000
21HIPK21.82997905
22EPHA31.81507106
23ACVR1B1.78920745
24MST1R1.63122680
25SIK11.58236720
26TNIK1.57312344
27LMTK21.52027615
28LATS21.47764460
29NUAK11.45427595
30ERBB31.41138551
31MAP3K11.40329962
32BRD41.39690339
33MET1.39135908
34PTK21.38479937
35DDR21.38130747
36FER1.35726946
37EIF2AK11.33813804
38PLK21.25361832
39STK241.25227942
40NEK11.23768656
41RET1.21519177
42MAP3K41.21161149
43PBK1.19614881
44ERBB41.19438562
45FGFR31.17233200
46CDC42BPA1.16951219
47WNK41.15588165
48NTRK11.13876822
49PDGFRB1.13020220
50CAMK1G1.07646648
51STK31.07404104
52MAPK151.04538645
53JAK11.04149868
54PRKCH1.03356066
55PAK31.00658438
56MYLK0.98559077
57SIK30.98231339
58PIK3CA0.97045730
59PKN20.96448940
60DMPK0.96152625
61MST40.94781266
62FLT30.94058068
63OXSR10.93070830
64TRPM70.90860032
65MAP2K20.90480368
66TSSK60.89108507
67CAMKK20.87332707
68KSR10.85718101
69KSR20.85514257
70PLK30.82892337
71EPHB10.80811404
72MTOR0.80610517
73MAP3K90.80177089
74TESK10.80104367
75WNK10.78939907
76MAP3K100.78857119
77STK380.77466798
78CDK120.76588000
79PAK40.76273786
80CAMKK10.75919527
81MAPKAPK30.74715191
82NEK90.74400110
83GRK10.73997499
84ALK0.73733187
85CAMK1D0.73659837
86JAK20.73314097
87GSK3A0.72454191
88FGFR40.72119274
89UHMK10.70949169
90NLK0.69695281
91EPHA20.67396234
92MKNK20.67223713
93FGFR20.67187221
94PRKD20.66426865
95PRKG20.65682821
96ICK0.65090804
97TAOK10.64440925
98DYRK1B0.63903197
99BRSK20.62423591
100PLK40.61327866
101SGK30.60669175
102LIMK10.60137255
103NTRK30.58568132
104PAK20.56955182
105EEF2K0.56857212
106TLK10.56777815
107PNCK0.56236016
108JAK30.55400104
109MAP3K120.52892717
110MAP2K10.51690832
111BMPR1B0.51221564
112EPHB20.50970327
113PRKD10.50796183
114YES10.49192688
115CHUK0.47811637
116ERBB20.47034355
117STK390.46917646
118PRKAA20.45181527
119PRKCI0.45064518
120CSNK1E0.44530050
121WNK30.43883852
122PLK10.43506191
123IRAK10.43098390
124ATM0.42887066
125* PRKAA10.42472219
126RPS6KA20.41828249
127MARK20.41010632
128AKT20.39726896
129IRAK30.39068098
130BMX0.38284624
131FGFR10.38020572
132PRKCE0.36802468
133CSNK1G10.35981450
134IGF1R0.34342387
135CDK60.33906103
136PIK3CG0.32678598
137ITK0.32584920
138RPS6KB10.32511311
139LRRK20.32415162
140MELK0.31047893
141PHKG10.30706625
142PHKG20.30706625
143PDK20.30665998
144PDPK10.30337839
145WEE10.30034654
146INSR0.28884140
147SRPK10.28566259
148ROCK10.28371962
149CSNK1A10.27293787
150EGFR0.26529363
151MAP3K70.25934643

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.68179640
2Sulfur metabolism_Homo sapiens_hsa009203.13824922
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.87804457
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.57806780
5Insulin secretion_Homo sapiens_hsa049112.39538252
6Vitamin B6 metabolism_Homo sapiens_hsa007502.33651358
7Type II diabetes mellitus_Homo sapiens_hsa049302.27131900
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04201203
9Protein export_Homo sapiens_hsa030601.95468519
10Carbohydrate digestion and absorption_Homo sapiens_hsa049731.89662270
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81272651
12Type I diabetes mellitus_Homo sapiens_hsa049401.73585311
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.68271671
14Pancreatic secretion_Homo sapiens_hsa049721.59828253
15N-Glycan biosynthesis_Homo sapiens_hsa005101.57561174
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54116642
17Fatty acid biosynthesis_Homo sapiens_hsa000611.52234651
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.49964048
19Protein digestion and absorption_Homo sapiens_hsa049741.45806396
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45747572
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45007027
22Thyroid hormone synthesis_Homo sapiens_hsa049181.44307904
23Arginine biosynthesis_Homo sapiens_hsa002201.43546613
24Propanoate metabolism_Homo sapiens_hsa006401.41145433
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.39080589
26Vibrio cholerae infection_Homo sapiens_hsa051101.36644456
27Steroid biosynthesis_Homo sapiens_hsa001001.34944074
28Retinol metabolism_Homo sapiens_hsa008301.34034929
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.30676544
30* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30359423
31Mineral absorption_Homo sapiens_hsa049781.28398827
32Caffeine metabolism_Homo sapiens_hsa002321.26690404
33Vitamin digestion and absorption_Homo sapiens_hsa049771.25323541
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23540307
35Fat digestion and absorption_Homo sapiens_hsa049751.21476590
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20735207
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20569187
38Cocaine addiction_Homo sapiens_hsa050301.18606900
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17762486
40Dorso-ventral axis formation_Homo sapiens_hsa043201.16066953
41mTOR signaling pathway_Homo sapiens_hsa041501.14164708
42Renin-angiotensin system_Homo sapiens_hsa046141.12684213
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09316532
44TGF-beta signaling pathway_Homo sapiens_hsa043501.08595146
45Adherens junction_Homo sapiens_hsa045201.08322005
46Pyruvate metabolism_Homo sapiens_hsa006201.07253533
47Estrogen signaling pathway_Homo sapiens_hsa049151.05625318
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04930844
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03356227
50* Insulin resistance_Homo sapiens_hsa049311.02398413
51Prolactin signaling pathway_Homo sapiens_hsa049171.01475710
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.01309100
53Lysosome_Homo sapiens_hsa041421.00095824
54One carbon pool by folate_Homo sapiens_hsa006700.98268441
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98038255
56Histidine metabolism_Homo sapiens_hsa003400.97694822
57Fatty acid metabolism_Homo sapiens_hsa012120.95332977
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94816690
59Chemical carcinogenesis_Homo sapiens_hsa052040.93701209
60Endometrial cancer_Homo sapiens_hsa052130.92917658
61Fatty acid degradation_Homo sapiens_hsa000710.91866740
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91691626
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90588702
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88829072
65Butanoate metabolism_Homo sapiens_hsa006500.88423443
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87139632
67Amphetamine addiction_Homo sapiens_hsa050310.86856285
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86575864
69Renin secretion_Homo sapiens_hsa049240.86342835
70Glucagon signaling pathway_Homo sapiens_hsa049220.85392340
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84535797
72Prostate cancer_Homo sapiens_hsa052150.84265152
73Focal adhesion_Homo sapiens_hsa045100.83093246
74Gastric acid secretion_Homo sapiens_hsa049710.81406678
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81073478
76Bladder cancer_Homo sapiens_hsa052190.79560694
77Cholinergic synapse_Homo sapiens_hsa047250.79331176
78Selenocompound metabolism_Homo sapiens_hsa004500.79131340
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78491692
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77825004
81Arginine and proline metabolism_Homo sapiens_hsa003300.76623794
82Chronic myeloid leukemia_Homo sapiens_hsa052200.75812443
83Inositol phosphate metabolism_Homo sapiens_hsa005620.74023382
84Long-term potentiation_Homo sapiens_hsa047200.73246579
85Bile secretion_Homo sapiens_hsa049760.73127621
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72961755
87Dopaminergic synapse_Homo sapiens_hsa047280.71730138
88MicroRNAs in cancer_Homo sapiens_hsa052060.71346252
89Amoebiasis_Homo sapiens_hsa051460.70089314
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.69779315
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69484191
92PPAR signaling pathway_Homo sapiens_hsa033200.69380555
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67228359
94Glutathione metabolism_Homo sapiens_hsa004800.67148978
95AMPK signaling pathway_Homo sapiens_hsa041520.66674671
96Proteoglycans in cancer_Homo sapiens_hsa052050.66419445
97Insulin signaling pathway_Homo sapiens_hsa049100.66277478
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65612231
99Thyroid cancer_Homo sapiens_hsa052160.64653509
100Complement and coagulation cascades_Homo sapiens_hsa046100.64519757
101Galactose metabolism_Homo sapiens_hsa000520.64477321
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.64423481
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63712272
104ECM-receptor interaction_Homo sapiens_hsa045120.63329923
105Tight junction_Homo sapiens_hsa045300.62912894
106Glioma_Homo sapiens_hsa052140.62555395
107Renal cell carcinoma_Homo sapiens_hsa052110.62435031
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.61455931
109Hedgehog signaling pathway_Homo sapiens_hsa043400.61418519
110Salivary secretion_Homo sapiens_hsa049700.61159646
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60674221
112Carbon metabolism_Homo sapiens_hsa012000.60378633
113ABC transporters_Homo sapiens_hsa020100.60087644
114Pancreatic cancer_Homo sapiens_hsa052120.59845560
115Fructose and mannose metabolism_Homo sapiens_hsa000510.59628466
116Starch and sucrose metabolism_Homo sapiens_hsa005000.57425364
117Circadian rhythm_Homo sapiens_hsa047100.57080326
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56811595
119GnRH signaling pathway_Homo sapiens_hsa049120.56694885
120Gap junction_Homo sapiens_hsa045400.56265325
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.55149893
122Toxoplasmosis_Homo sapiens_hsa051450.54683154
123Taste transduction_Homo sapiens_hsa047420.54437411
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53359015
125Melanogenesis_Homo sapiens_hsa049160.52411722
126Glycerolipid metabolism_Homo sapiens_hsa005610.52356483
127Basal cell carcinoma_Homo sapiens_hsa052170.51934224
128Tyrosine metabolism_Homo sapiens_hsa003500.51756645
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51585085
130Non-homologous end-joining_Homo sapiens_hsa034500.50482766
131Fatty acid elongation_Homo sapiens_hsa000620.48712072
132Biosynthesis of amino acids_Homo sapiens_hsa012300.48701117
133Melanoma_Homo sapiens_hsa052180.48085230
134ErbB signaling pathway_Homo sapiens_hsa040120.47462142
135TNF signaling pathway_Homo sapiens_hsa046680.47132032
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46805211
137Nitrogen metabolism_Homo sapiens_hsa009100.46333839
138* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45436848
139Circadian entrainment_Homo sapiens_hsa047130.45182690
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.44988452
141Wnt signaling pathway_Homo sapiens_hsa043100.44733444
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.43989216
143RNA transport_Homo sapiens_hsa030130.43877936
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43535488
145Prion diseases_Homo sapiens_hsa050200.43205347
146FoxO signaling pathway_Homo sapiens_hsa040680.43149829
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42401107
148cAMP signaling pathway_Homo sapiens_hsa040240.41160070
149Lysine degradation_Homo sapiens_hsa003100.41039753
150Antigen processing and presentation_Homo sapiens_hsa046120.40531634
151Small cell lung cancer_Homo sapiens_hsa052220.40509912
152Hippo signaling pathway_Homo sapiens_hsa043900.39420952
153Endocytosis_Homo sapiens_hsa041440.38342813
154Central carbon metabolism in cancer_Homo sapiens_hsa052300.36612075
155Sphingolipid metabolism_Homo sapiens_hsa006000.36528823
156Hepatitis C_Homo sapiens_hsa051600.36525974
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.36098249

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