GFRA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.37364409
2L-phenylalanine catabolic process (GO:0006559)7.37364409
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.93229367
4L-phenylalanine metabolic process (GO:0006558)6.93229367
5aromatic amino acid family catabolic process (GO:0009074)6.51355294
6tryptophan catabolic process (GO:0006569)5.78199251
7indole-containing compound catabolic process (GO:0042436)5.78199251
8indolalkylamine catabolic process (GO:0046218)5.78199251
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.73765346
10kynurenine metabolic process (GO:0070189)5.71622410
11bile acid biosynthetic process (GO:0006699)5.68781314
12alpha-linolenic acid metabolic process (GO:0036109)5.40763329
13glyoxylate metabolic process (GO:0046487)5.39890003
14tryptophan metabolic process (GO:0006568)5.39114751
15urea metabolic process (GO:0019627)5.36715333
16urea cycle (GO:0000050)5.36715333
17negative regulation of fibrinolysis (GO:0051918)5.33112534
18regulation of protein activation cascade (GO:2000257)5.14790526
19regulation of fibrinolysis (GO:0051917)5.13723385
20complement activation, alternative pathway (GO:0006957)5.10993653
21high-density lipoprotein particle remodeling (GO:0034375)5.10116374
22sulfur amino acid catabolic process (GO:0000098)5.05134439
23nitrogen cycle metabolic process (GO:0071941)4.94556825
24cysteine metabolic process (GO:0006534)4.94051584
25peptidyl-glutamic acid carboxylation (GO:0017187)4.86718577
26protein carboxylation (GO:0018214)4.86718577
27regulation of complement activation (GO:0030449)4.79091303
28bile acid metabolic process (GO:0008206)4.77330165
29aromatic amino acid family metabolic process (GO:0009072)4.76392812
30tyrosine metabolic process (GO:0006570)4.76011548
31reverse cholesterol transport (GO:0043691)4.60671341
32serine family amino acid catabolic process (GO:0009071)4.54634707
33coenzyme catabolic process (GO:0009109)4.50303862
34regulation of cholesterol esterification (GO:0010872)4.42180476
35regulation of triglyceride catabolic process (GO:0010896)4.41168249
36cellular ketone body metabolic process (GO:0046950)4.39842409
37homocysteine metabolic process (GO:0050667)4.38739623
38alpha-amino acid catabolic process (GO:1901606)4.37659395
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36660708
40indolalkylamine metabolic process (GO:0006586)4.35246044
41protein-lipid complex remodeling (GO:0034368)4.33510073
42macromolecular complex remodeling (GO:0034367)4.33510073
43plasma lipoprotein particle remodeling (GO:0034369)4.33510073
44lysine metabolic process (GO:0006553)4.28154525
45lysine catabolic process (GO:0006554)4.28154525
46glutamate metabolic process (GO:0006536)4.20573763
47negative regulation of sterol transport (GO:0032372)4.17324272
48negative regulation of cholesterol transport (GO:0032375)4.17324272
49cellular modified amino acid catabolic process (GO:0042219)4.14692825
50triglyceride homeostasis (GO:0070328)4.12725993
51acylglycerol homeostasis (GO:0055090)4.12725993
52dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.12612706
53amino-acid betaine metabolic process (GO:0006577)4.10136703
54bile acid and bile salt transport (GO:0015721)4.06527570
55cellular amino acid catabolic process (GO:0009063)4.04780254
56phospholipid efflux (GO:0033700)4.04134332
57ethanol oxidation (GO:0006069)4.01555503
58regulation of axon extension involved in axon guidance (GO:0048841)4.00385772
59dicarboxylic acid biosynthetic process (GO:0043650)4.00233792
60cell migration in hindbrain (GO:0021535)3.99078981
61arginine metabolic process (GO:0006525)3.95158849
62cellular biogenic amine catabolic process (GO:0042402)3.94531620
63amine catabolic process (GO:0009310)3.94531620
64cholesterol efflux (GO:0033344)3.90524293
65plasma lipoprotein particle clearance (GO:0034381)3.88532983
66benzene-containing compound metabolic process (GO:0042537)3.83205187
67cellular glucuronidation (GO:0052695)3.82311161
68ketone body metabolic process (GO:1902224)3.79011749
69regulation of axon guidance (GO:1902667)3.76889112
70regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.76493823
71pyrimidine nucleobase catabolic process (GO:0006208)3.72537171
72glycine metabolic process (GO:0006544)3.72503032
73fibrinolysis (GO:0042730)3.71920624
74imidazole-containing compound metabolic process (GO:0052803)3.71819128
75serine family amino acid metabolic process (GO:0009069)3.69323969
76planar cell polarity pathway involved in neural tube closure (GO:0090179)3.68539807
77serine family amino acid biosynthetic process (GO:0009070)3.66524527
78negative regulation of protein activation cascade (GO:2000258)3.65829755
79ear development (GO:0043583)3.65108734
80low-density lipoprotein particle remodeling (GO:0034374)3.62832424
81acetyl-CoA metabolic process (GO:0006084)3.61905486
82complement activation, classical pathway (GO:0006958)3.60827144
83regulation of bile acid biosynthetic process (GO:0070857)3.60251762
84cofactor catabolic process (GO:0051187)3.59206480
85plasma lipoprotein particle assembly (GO:0034377)3.59176918
86cytolysis (GO:0019835)3.57892420
87embryonic camera-type eye morphogenesis (GO:0048596)3.56839305
88embryonic retina morphogenesis in camera-type eye (GO:0060059)3.56247894
89complement activation (GO:0006956)3.53455719
90drug catabolic process (GO:0042737)3.50471343
91negative regulation of axon extension involved in axon guidance (GO:0048843)3.49768641
92aldehyde catabolic process (GO:0046185)3.49716999
93negative regulation of lipase activity (GO:0060192)3.47264584
94aspartate family amino acid catabolic process (GO:0009068)3.45945896
95neuron recognition (GO:0008038)3.44696499
96carboxylic acid catabolic process (GO:0046395)3.44416332
97organic acid catabolic process (GO:0016054)3.44416332
98very-low-density lipoprotein particle assembly (GO:0034379)3.42466751
99protein activation cascade (GO:0072376)3.41678258
100regulation of cholesterol homeostasis (GO:2000188)3.39600216
101positive regulation of lipid catabolic process (GO:0050996)3.38720528
102uronic acid metabolic process (GO:0006063)3.37406645
103glucuronate metabolic process (GO:0019585)3.37406645
104negative regulation of fatty acid transport (GO:2000192)3.37324618
105heme transport (GO:0015886)3.37234672
106insulin-like growth factor receptor signaling pathway (GO:0048009)3.35414663
107phospholipid homeostasis (GO:0055091)3.33833866
108regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.33772932
109very long-chain fatty acid metabolic process (GO:0000038)3.33339408
110axonal fasciculation (GO:0007413)3.33061536
111blood coagulation, intrinsic pathway (GO:0007597)3.32349297
112protein-lipid complex assembly (GO:0065005)3.31504916
113alkaloid metabolic process (GO:0009820)3.31053461
114positive regulation of lipoprotein lipase activity (GO:0051006)3.30833191
115positive regulation of triglyceride lipase activity (GO:0061365)3.30833191
116apical protein localization (GO:0045176)3.30136215
117axon extension involved in axon guidance (GO:0048846)3.26806496
118neuron projection extension involved in neuron projection guidance (GO:1902284)3.26806496
119negative regulation of axon guidance (GO:1902668)3.22658736
120metanephric mesenchyme development (GO:0072075)3.21380039
121negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.15890058
122collagen fibril organization (GO:0030199)3.15829746
123embryonic eye morphogenesis (GO:0048048)3.10044814
124axon extension (GO:0048675)3.09378653
125vagina development (GO:0060068)3.06942256
126kidney mesenchyme development (GO:0072074)3.06081911
127regulation of glucose import in response to insulin stimulus (GO:2001273)3.02086419
128paraxial mesoderm development (GO:0048339)3.01196610
129eye morphogenesis (GO:0048592)3.00611304
130uterus development (GO:0060065)2.98968975
131myoblast fusion (GO:0007520)2.95907535
132regulation of fatty acid beta-oxidation (GO:0031998)2.94199352
133establishment of planar polarity (GO:0001736)2.90131481
134establishment of tissue polarity (GO:0007164)2.90131481
135chondrocyte development (GO:0002063)2.89588872
136camera-type eye morphogenesis (GO:0048593)2.86154534
137negative regulation of embryonic development (GO:0045992)2.84639128
138asymmetric protein localization (GO:0008105)2.78613423
139semaphorin-plexin signaling pathway (GO:0071526)2.78081272
140cell proliferation involved in metanephros development (GO:0072203)2.75575059
141protein heterotrimerization (GO:0070208)2.73885488
142mesenchyme morphogenesis (GO:0072132)2.73203079
143dendrite morphogenesis (GO:0048813)2.72798298
144adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.72417681
145Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.72370386
146positive regulation of fatty acid beta-oxidation (GO:0032000)2.71690480
147glomerular basement membrane development (GO:0032836)2.70369928
148regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66799901
149cardiac right ventricle morphogenesis (GO:0003215)2.66365427
150innervation (GO:0060384)2.60637499
151mesonephros development (GO:0001823)2.59963874
152dopaminergic neuron differentiation (GO:0071542)2.59795536
153syncytium formation by plasma membrane fusion (GO:0000768)2.59126807
154ganglion development (GO:0061548)2.58661980
155neuron projection extension (GO:1990138)2.56114990
156regulation of establishment of planar polarity (GO:0090175)2.55389219
157maternal placenta development (GO:0001893)2.49707950
158mating behavior (GO:0007617)2.42860998
159positive regulation of keratinocyte differentiation (GO:0045618)2.42742276
160ectodermal placode formation (GO:0060788)2.42532752
161heparan sulfate proteoglycan metabolic process (GO:0030201)2.42060318
162response to water (GO:0009415)2.42048195
163body morphogenesis (GO:0010171)2.41291797
164regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.40783162
165G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.40780955
166response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.40205866
167female genitalia development (GO:0030540)2.40053921
168branching involved in salivary gland morphogenesis (GO:0060445)2.39271328
169negative chemotaxis (GO:0050919)2.38765183
170endocardial cushion morphogenesis (GO:0003203)2.36925406
171sympathetic nervous system development (GO:0048485)2.36659321
172adherens junction assembly (GO:0034333)2.36396310
173establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.35291509
174mesenchymal to epithelial transition (GO:0060231)2.34695317
175endothelial cell chemotaxis (GO:0035767)2.34110940
176developmental growth involved in morphogenesis (GO:0060560)2.33982324
177protein retention in ER lumen (GO:0006621)2.31343365
178mesenchymal-epithelial cell signaling (GO:0060638)2.31094138
179prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.29906988
180facial nerve structural organization (GO:0021612)2.28712846
181dopamine receptor signaling pathway (GO:0007212)2.26503442
182regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.25531490
183central nervous system projection neuron axonogenesis (GO:0021952)2.25077560
184bone trabecula formation (GO:0060346)2.24907696
185vascular endothelial growth factor signaling pathway (GO:0038084)2.24804232
186norepinephrine metabolic process (GO:0042415)2.23795316
187cochlea morphogenesis (GO:0090103)2.23043677
188skeletal muscle organ development (GO:0060538)2.22892663
189convergent extension (GO:0060026)2.22317524
190positive regulation of axon extension (GO:0045773)2.19706072
191negative regulation of organelle assembly (GO:1902116)2.18200225
192negative regulation of catenin import into nucleus (GO:0035414)2.18083012
193striated muscle atrophy (GO:0014891)2.17648106
194nucleobase catabolic process (GO:0046113)2.17029367
195skin morphogenesis (GO:0043589)2.16358770
196positive regulation of mesonephros development (GO:0061213)2.16227937
197negative regulation of cell size (GO:0045792)2.15694457
198cellular response to prostaglandin stimulus (GO:0071379)2.15466473
199developmental cell growth (GO:0048588)2.15165316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.78328289
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.70362706
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.52474106
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.34446252
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.24184229
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.48189520
7RBPJ_22232070_ChIP-Seq_NCS_Mouse4.06719404
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.62056007
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.53512928
10* ESR1_21235772_ChIP-Seq_MCF-7_Human3.45789163
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.33431303
12TP63_17297297_ChIP-ChIP_HaCaT_Human3.16957446
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.79095627
14AHR_22903824_ChIP-Seq_MCF-7_Human2.38210519
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.20366585
16ARNT_22903824_ChIP-Seq_MCF-7_Human1.95634166
17* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89277018
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.79264572
19* TP53_20018659_ChIP-ChIP_R1E_Mouse1.74206136
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72964571
21* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72368918
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.67365884
23* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63118051
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57807632
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.57009614
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55055468
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.54719003
28HTT_18923047_ChIP-ChIP_STHdh_Human1.54405859
29* RING1B_27294783_Chip-Seq_NPCs_Mouse1.47403703
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46545887
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43141260
32AR_21572438_ChIP-Seq_LNCaP_Human1.39346534
33ISL1_27105846_Chip-Seq_CPCs_Mouse1.35789676
34KDM2B_26808549_Chip-Seq_K562_Human1.34378013
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34190805
36* TAF15_26573619_Chip-Seq_HEK293_Human1.33790809
37GBX2_23144817_ChIP-Seq_PC3_Human1.31946469
38* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30427756
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29364736
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28679240
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28230723
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27619763
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27354582
44YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26940492
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26717649
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24892546
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24441169
48* RACK7_27058665_Chip-Seq_MCF-7_Human1.22408106
49CLOCK_20551151_ChIP-Seq_293T_Human1.21985712
50EZH2_22144423_ChIP-Seq_EOC_Human1.21419835
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20730002
52* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19309365
53ER_23166858_ChIP-Seq_MCF-7_Human1.18159013
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.16558359
55* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16491366
56* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15792738
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15471251
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.14991124
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13914885
60HNF4A_19822575_ChIP-Seq_HepG2_Human1.13170397
61* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12709819
62* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12709819
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12652310
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12431415
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10961999
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10183701
67TP53_18474530_ChIP-ChIP_U2OS_Human1.10151094
68* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09207996
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08849566
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08039576
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06553398
72* EED_16625203_ChIP-ChIP_MESCs_Mouse1.05990120
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05355650
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.04504473
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04127736
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03649292
77* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02896985
78* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02771168
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00921776
80RNF2_27304074_Chip-Seq_NSC_Mouse1.00710763
81* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00704304
82CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98890841
83SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97773359
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97596729
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97541399
86TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97071224
87TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96212597
88* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96131545
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95733448
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94979978
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93320181
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91788206
93* EZH2_27294783_Chip-Seq_ESCs_Mouse0.91270870
94CJUN_26792858_Chip-Seq_BT549_Human0.90806115
95RARB_27405468_Chip-Seq_BRAIN_Mouse0.89604184
96PIAS1_25552417_ChIP-Seq_VCAP_Human0.89509879
97* EZH2_27304074_Chip-Seq_ESCs_Mouse0.89355352
98* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88192466
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87927339
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87927339
101ZNF263_19887448_ChIP-Seq_K562_Human0.87767948
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87351839
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87301714
104* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86613843
105REST_18959480_ChIP-ChIP_MESCs_Mouse0.85193837
106* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84631651
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83410453
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82892370
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82555095
110* ESR2_21235772_ChIP-Seq_MCF-7_Human0.81714965
111REST_21632747_ChIP-Seq_MESCs_Mouse0.81530939
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80989216
113TRIM28_21343339_ChIP-Seq_HEK293_Human0.80494164
114DROSHA_22980978_ChIP-Seq_HELA_Human0.79667885
115RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79543303
116CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79292487
117* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78770166
118CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78373600
119BCAT_22108803_ChIP-Seq_LS180_Human0.75424613
120AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74993756
121SOX2_21211035_ChIP-Seq_LN229_Gbm0.73230141
122* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73133187
123* RNF2_27304074_Chip-Seq_ESCs_Mouse0.71800761
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71665926
125P300_19829295_ChIP-Seq_ESCs_Human0.69206175
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.69090032
127CTCF_27219007_Chip-Seq_Bcells_Human0.68968798
128* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.68544479
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.68442765
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.67087408
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64078271
132* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.62927524
133* SMAD4_21799915_ChIP-Seq_A2780_Human0.62495207
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.62251445
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.61755134
136* RING1B_27294783_Chip-Seq_ESCs_Mouse0.60474919
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.60027101
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.59374330
139* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.58415688
140* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.57865577
141* CBP_21632823_ChIP-Seq_H3396_Human0.56164871
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55544696
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55235402
144MYC_19915707_ChIP-ChIP_AK7_Human0.54151881
145CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.54036100
146AR_25329375_ChIP-Seq_VCAP_Human0.53358290
147EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.52867105
148SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.52783578
149* AR_19668381_ChIP-Seq_PC3_Human0.52704178
150* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.52516880
151LXR_22292898_ChIP-Seq_THP-1_Human0.52361268
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.52347755
153MYC_27129775_Chip-Seq_CORNEA_Mouse0.52256660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.44403397
2MP0005360_urolithiasis7.07663452
3MP0005085_abnormal_gallbladder_physiolo6.05163717
4MP0005365_abnormal_bile_salt5.76839750
5MP0008875_abnormal_xenobiotic_pharmacok4.82605061
6MP0008438_abnormal_cutaneous_collagen4.22232320
7MP0003252_abnormal_bile_duct3.65935951
8MP0003806_abnormal_nucleotide_metabolis3.49578826
9MP0010329_abnormal_lipoprotein_level3.33750663
10MP0005503_abnormal_tendon_morphology3.28568096
11MP0009840_abnormal_foam_cell2.94478380
12MP0005275_abnormal_skin_tensile2.79629357
13MP0005083_abnormal_biliary_tract2.77948108
14MP0009780_abnormal_chondrocyte_physiolo2.68341590
15MP0005332_abnormal_amino_acid2.59185550
16MP0003195_calcinosis2.41508020
17MP0001666_abnormal_nutrient_absorption2.31474867
18MP0003868_abnormal_feces_composition2.03643507
19MP0005257_abnormal_intraocular_pressure2.00489554
20* MP0003942_abnormal_urinary_system1.98379811
21MP0002118_abnormal_lipid_homeostasis1.96463860
22* MP0002184_abnormal_innervation1.91599422
23MP0002108_abnormal_muscle_morphology1.85306321
24MP0000609_abnormal_liver_physiology1.84376749
25MP0003191_abnormal_cellular_cholesterol1.84193239
26* MP0000534_abnormal_ureter_morphology1.80879572
27MP0004019_abnormal_vitamin_homeostasis1.78913199
28MP0010030_abnormal_orbit_morphology1.76051597
29MP0004272_abnormal_basement_membrane1.75039182
30MP0001299_abnormal_eye_distance/1.74139598
31MP0001958_emphysema1.72879249
32MP0005409_darkened_coat_color1.68807393
33MP0005076_abnormal_cell_differentiation1.59988695
34MP0002249_abnormal_larynx_morphology1.50246937
35MP0003329_amyloid_beta_deposits1.49571444
36MP0005584_abnormal_enzyme/coenzyme_acti1.48809364
37MP0000537_abnormal_urethra_morphology1.46733066
38MP0003011_delayed_dark_adaptation1.46553141
39MP0005319_abnormal_enzyme/_coenzyme1.42674284
40MP0003122_maternal_imprinting1.40091598
41MP0000604_amyloidosis1.38131749
42MP0000733_abnormal_muscle_development1.36302886
43MP0006276_abnormal_autonomic_nervous1.34540392
44MP0009697_abnormal_copulation1.32392798
45MP0002734_abnormal_mechanical_nocicepti1.31953358
46MP0002138_abnormal_hepatobiliary_system1.31340959
47MP0002877_abnormal_melanocyte_morpholog1.29332214
48MP0001542_abnormal_bone_strength1.28973499
49MP0005508_abnormal_skeleton_morphology1.25975047
50MP0003941_abnormal_skin_development1.25879235
51MP0002932_abnormal_joint_morphology1.25817335
52MP0002896_abnormal_bone_mineralization1.23820508
53MP0009250_abnormal_appendicular_skeleto1.23818586
54MP0002089_abnormal_postnatal_growth/wei1.23647625
55MP0005171_absent_coat_pigmentation1.21593919
56MP0002697_abnormal_eye_size1.21503840
57MP0003385_abnormal_body_wall1.20057291
58MP0004233_abnormal_muscle_weight1.19363773
59* MP0000955_abnormal_spinal_cord1.19073705
60MP0003690_abnormal_glial_cell1.17518903
61MP0001764_abnormal_homeostasis1.16547126
62MP0003283_abnormal_digestive_organ1.14913571
63* MP0002751_abnormal_autonomic_nervous1.14354104
64MP0003115_abnormal_respiratory_system1.13649326
65MP0000751_myopathy1.13173444
66MP0003880_abnormal_central_pattern1.11796277
67MP0005451_abnormal_body_composition1.10805686
68MP0002116_abnormal_craniofacial_bone1.09528502
69MP0003279_aneurysm1.06914253
70MP0005647_abnormal_sex_gland1.06319495
71MP0001849_ear_inflammation1.04186426
72MP0000383_abnormal_hair_follicle1.03736988
73MP0005623_abnormal_meninges_morphology1.01280342
74MP0003935_abnormal_craniofacial_develop0.99680176
75MP0002822_catalepsy0.99356952
76MP0003705_abnormal_hypodermis_morpholog0.98142214
77MP0000428_abnormal_craniofacial_morphol0.98076006
78MP0003656_abnormal_erythrocyte_physiolo0.97059093
79MP0005197_abnormal_uvea_morphology0.96111215
80MP0002092_abnormal_eye_morphology0.95385627
81MP0002796_impaired_skin_barrier0.95189808
82MP0000049_abnormal_middle_ear0.95021997
83MP0003937_abnormal_limbs/digits/tail_de0.94151156
84* MP0000462_abnormal_digestive_system0.92601443
85* MP0003861_abnormal_nervous_system0.92375776
86MP0000762_abnormal_tongue_morphology0.88971863
87MP0002060_abnormal_skin_morphology0.88556192
88MP0000767_abnormal_smooth_muscle0.88519170
89MP0003091_abnormal_cell_migration0.88382624
90MP0003755_abnormal_palate_morphology0.87981006
91MP0000467_abnormal_esophagus_morphology0.86930082
92MP0002160_abnormal_reproductive_system0.86573813
93* MP0002081_perinatal_lethality0.86524147
94MP0010386_abnormal_urinary_bladder0.86425543
95MP0009643_abnormal_urine_homeostasis0.86167477
96MP0004859_abnormal_synaptic_plasticity0.85807439
97MP0004270_analgesia0.85800007
98MP0003123_paternal_imprinting0.85737265
99MP0005535_abnormal_body_temperature0.85411551
100MP0000639_abnormal_adrenal_gland0.85329861
101MP0000750_abnormal_muscle_regeneration0.85224074
102MP0009672_abnormal_birth_weight0.84878558
103MP0003634_abnormal_glial_cell0.84451116
104MP0000598_abnormal_liver_morphology0.84429084
105MP0001348_abnormal_lacrimal_gland0.81546470
106MP0002152_abnormal_brain_morphology0.80871807
107MP0002282_abnormal_trachea_morphology0.80757997
108MP0002114_abnormal_axial_skeleton0.79624879
109* MP0002882_abnormal_neuron_morphology0.78719190
110MP0009703_decreased_birth_body0.77983723
111MP0005248_abnormal_Harderian_gland0.77956170
112MP0002233_abnormal_nose_morphology0.77917559
113MP0002177_abnormal_outer_ear0.77657681
114MP0004858_abnormal_nervous_system0.77064085
115MP0003938_abnormal_ear_development0.76884383
116MP0009764_decreased_sensitivity_to0.74551431
117MP0002078_abnormal_glucose_homeostasis0.73116907
118MP0000163_abnormal_cartilage_morphology0.73051939
119MP0005408_hypopigmentation0.71474540
120MP0001340_abnormal_eyelid_morphology0.71287322
121MP0001661_extended_life_span0.70705423
122* MP0000538_abnormal_urinary_bladder0.70635545
123MP0009642_abnormal_blood_homeostasis0.69893483
124MP0002254_reproductive_system_inflammat0.69075933
125MP0001243_abnormal_dermal_layer0.68786572
126MP0005595_abnormal_vascular_smooth0.68726190
127MP0003948_abnormal_gas_homeostasis0.68657658
128MP0002733_abnormal_thermal_nociception0.68331743
129MP0005646_abnormal_pituitary_gland0.68324956
130MP0005636_abnormal_mineral_homeostasis0.68278997
131MP0004134_abnormal_chest_morphology0.68149903
132MP0000920_abnormal_myelination0.67001345
133MP0004130_abnormal_muscle_cell0.65889096
134MP0005220_abnormal_exocrine_pancreas0.65359884
135MP0009384_cardiac_valve_regurgitation0.64187633
136MP0002971_abnormal_brown_adipose0.63413239
137MP0000579_abnormal_nail_morphology0.63396219
138MP0001968_abnormal_touch/_nociception0.62471521
139MP0002876_abnormal_thyroid_physiology0.62390577
140MP0009763_increased_sensitivity_to0.61317981
141MP0005376_homeostasis/metabolism_phenot0.60985142
142MP0008874_decreased_physiological_sensi0.60954488
143MP0005448_abnormal_energy_balance0.59305365
144MP0005423_abnormal_somatic_nervous0.59136647
145MP0009765_abnormal_xenobiotic_induced0.58679390
146MP0002090_abnormal_vision0.57591534
147MP0003186_abnormal_redox_activity0.57454357
148* MP0003635_abnormal_synaptic_transmissio0.56832517
149MP0005670_abnormal_white_adipose0.56237217
150MP0002064_seizures0.55642326
151MP0005334_abnormal_fat_pad0.54819621
152MP0002063_abnormal_learning/memory/cond0.54633669
153MP0009053_abnormal_anal_canal0.53709437
154MP0008872_abnormal_physiological_respon0.53692563
155* MP0003632_abnormal_nervous_system0.53688499
156MP0004142_abnormal_muscle_tone0.53052129
157MP0002837_dystrophic_cardiac_calcinosis0.52644333
158MP0001529_abnormal_vocalization0.52545814
159MP0001486_abnormal_startle_reflex0.52309552
160MP0009745_abnormal_behavioral_response0.50831448
161MP0001905_abnormal_dopamine_level0.50682012
162MP0010368_abnormal_lymphatic_system0.50285616
163MP0000778_abnormal_nervous_system0.50091135
164MP0005084_abnormal_gallbladder_morpholo0.48942351
165MP0002735_abnormal_chemical_nociception0.48926738
166MP0005645_abnormal_hypothalamus_physiol0.47989608
167MP0005187_abnormal_penis_morphology0.47474614
168MP0005266_abnormal_metabolism0.46913796
169MP0006036_abnormal_mitochondrial_physio0.46257749
170MP0002572_abnormal_emotion/affect_behav0.46170617
171MP0002736_abnormal_nociception_after0.45890099
172MP0006035_abnormal_mitochondrial_morpho0.45703754
173MP0001756_abnormal_urination0.45611529
174MP0002069_abnormal_eating/drinking_beha0.44683676
175MP0001984_abnormal_olfaction0.44344243
176MP0003953_abnormal_hormone_level0.43434313
177* MP0003631_nervous_system_phenotype0.42116337
178MP0001177_atelectasis0.41402777
179MP0003633_abnormal_nervous_system0.40992197
180MP0002909_abnormal_adrenal_gland0.40817101

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.55765332
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.15281787
3Intrahepatic cholestasis (HP:0001406)6.90079798
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.22615209
5Prolonged partial thromboplastin time (HP:0003645)6.15796530
6Xanthomatosis (HP:0000991)6.10031819
7Hypobetalipoproteinemia (HP:0003563)6.08655881
8Hyperlipoproteinemia (HP:0010980)5.51881523
9Complement deficiency (HP:0004431)5.48472893
10Hypolipoproteinemia (HP:0010981)4.51817646
11Epidermoid cyst (HP:0200040)4.42995728
12Hyperammonemia (HP:0001987)4.35500809
13Protrusio acetabuli (HP:0003179)4.31087072
14Ketosis (HP:0001946)4.21248095
15Joint hemorrhage (HP:0005261)4.19002439
16Absent frontal sinuses (HP:0002688)4.15942197
17Abnormality of the common coagulation pathway (HP:0010990)4.15488025
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.09464444
19Hyperglycinemia (HP:0002154)4.06718855
20Abnormality of methionine metabolism (HP:0010901)4.04117026
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.02068993
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01751120
23Hypoalphalipoproteinemia (HP:0003233)3.97723286
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.89870445
25Abnormality of complement system (HP:0005339)3.84266869
26Asymmetry of the thorax (HP:0001555)3.79222762
27Premature rupture of membranes (HP:0001788)3.79184280
28Fat malabsorption (HP:0002630)3.76764166
29Abnormality of glycine metabolism (HP:0010895)3.59486038
30Abnormality of serine family amino acid metabolism (HP:0010894)3.59486038
31Hyperglycinuria (HP:0003108)3.40173269
32Hypercholesterolemia (HP:0003124)3.38719745
33Vascular tortuosity (HP:0004948)3.34925704
34Arterial tortuosity (HP:0005116)3.33462716
35Conjugated hyperbilirubinemia (HP:0002908)3.28216395
36Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.27999263
37Abnormality of the intrinsic pathway (HP:0010989)3.23828672
38Abnormality of pyrimidine metabolism (HP:0004353)3.20505108
39J-shaped sella turcica (HP:0002680)3.20361293
40Spontaneous abortion (HP:0005268)3.17422544
41Hypoglycemic coma (HP:0001325)3.16829556
42Aortic dissection (HP:0002647)3.12983552
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.09459355
44Delayed CNS myelination (HP:0002188)3.09352768
45Ketoacidosis (HP:0001993)3.03751995
46Skin nodule (HP:0200036)3.01569047
47Broad metatarsal (HP:0001783)3.00085301
48Hyperbilirubinemia (HP:0002904)2.87059019
49Abnormality of serum amino acid levels (HP:0003112)2.79316265
50Bladder diverticulum (HP:0000015)2.78195067
51Steatorrhea (HP:0002570)2.77012343
52Microglossia (HP:0000171)2.76600249
53Abnormality of fatty-acid metabolism (HP:0004359)2.75937833
54Soft skin (HP:0000977)2.74774176
55Abnormality of the frontal sinuses (HP:0002687)2.74467052
56Mitral stenosis (HP:0001718)2.71779303
57Morphological abnormality of the middle ear (HP:0008609)2.65816761
58Atrophic scars (HP:0001075)2.65510944
59Cholecystitis (HP:0001082)2.63349211
60Abnormal gallbladder physiology (HP:0012438)2.63349211
61Neonatal short-limb short stature (HP:0008921)2.63090110
62Hyperacusis (HP:0010780)2.62577141
63Abnormality of nucleobase metabolism (HP:0010932)2.58558965
64Amyloidosis (HP:0011034)2.58380267
65Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.56782407
66Hepatocellular carcinoma (HP:0001402)2.56718062
67Shallow orbits (HP:0000586)2.55544455
68Ankle contracture (HP:0006466)2.51165559
69Syringomyelia (HP:0003396)2.50323994
70Spinal cord lesions (HP:0100561)2.50323994
71Long toe (HP:0010511)2.48031437
72Neonatal onset (HP:0003623)2.47449177
73Biconcave vertebral bodies (HP:0004586)2.46083230
74Hypochromic microcytic anemia (HP:0004840)2.42647361
75Bowel diverticulosis (HP:0005222)2.42457368
76Genu recurvatum (HP:0002816)2.40996156
77Thin bony cortex (HP:0002753)2.40541310
78Abnormal gallbladder morphology (HP:0012437)2.39717943
79Deformed sella turcica (HP:0002681)2.39687747
80Gout (HP:0001997)2.39178100
81Metabolic acidosis (HP:0001942)2.37608043
82Myocardial infarction (HP:0001658)2.37003035
83Mildly elevated creatine phosphokinase (HP:0008180)2.36788349
84Irritability (HP:0000737)2.36526174
85Cholelithiasis (HP:0001081)2.32041160
86Hypoglycemic seizures (HP:0002173)2.31333533
87Cervical subluxation (HP:0003308)2.31028110
88Sensorimotor neuropathy (HP:0007141)2.31009511
89Abnormality of purine metabolism (HP:0004352)2.27585893
90Enlarged penis (HP:0000040)2.25035094
91Lethargy (HP:0001254)2.24656520
92Abnormality of the ischium (HP:0003174)2.23391706
93Abnormality of dentin (HP:0010299)2.23222405
94Buphthalmos (HP:0000557)2.22966101
95Aortic aneurysm (HP:0004942)2.22727724
96Cerebral aneurysm (HP:0004944)2.21768988
97Systemic lupus erythematosus (HP:0002725)2.20041985
98Mitral valve prolapse (HP:0001634)2.19907803
99Spastic diplegia (HP:0001264)2.19575504
100Acanthocytosis (HP:0001927)2.17247307
101Wormian bones (HP:0002645)2.17033956
102Flat cornea (HP:0007720)2.16699161
103Cerebral edema (HP:0002181)2.16568821
104Glomerulonephritis (HP:0000099)2.15454083
105Renovascular hypertension (HP:0100817)2.14236574
106Ulnar claw (HP:0001178)2.13601118
107Status epilepticus (HP:0002133)2.08617353
108Thin ribs (HP:0000883)2.07034577
109Late onset (HP:0003584)2.07022687
110Mitral regurgitation (HP:0001653)2.04524883
111Breech presentation (HP:0001623)2.04326266
112Hypoventilation (HP:0002791)2.02385669
113Congenital glaucoma (HP:0001087)2.02113272
114Neurofibrillary tangles (HP:0002185)2.01186977
115Vascular calcification (HP:0004934)2.00961803
116Exostoses (HP:0100777)2.00271645
117Type 1 muscle fiber predominance (HP:0003803)1.98600100
118Brushfield spots (HP:0001088)1.98313279
119Hypoplastic ischia (HP:0003175)1.98274556
120Dicarboxylic aciduria (HP:0003215)1.97794304
121Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97794304
122Abnormality of the gallbladder (HP:0005264)1.96827161
123Wide anterior fontanel (HP:0000260)1.96268942
124Hyperextensible skin (HP:0000974)1.95273978
125Aortic regurgitation (HP:0001659)1.94168309
126Deviation of the hallux (HP:0010051)1.93240095
127Osteoarthritis (HP:0002758)1.93100057
128Abnormality of the sella turcica (HP:0002679)1.91912292
129Renal duplication (HP:0000075)1.90972589
130Hallux valgus (HP:0001822)1.90751631
131Patellar dislocation (HP:0002999)1.90233259
132Pterygium (HP:0001059)1.89464886
133Craniofacial dystonia (HP:0012179)1.88598519
134Opisthotonus (HP:0002179)1.87490749
135Enlarged kidneys (HP:0000105)1.86887827
136Torticollis (HP:0000473)1.86848218
137Deformed tarsal bones (HP:0008119)1.86570026
138Overgrowth (HP:0001548)1.86542377
139Concave nail (HP:0001598)1.86316209
140Back pain (HP:0003418)1.83493435
141Coronal craniosynostosis (HP:0004440)1.83285910
142Rickets (HP:0002748)1.83134530
143Turricephaly (HP:0000262)1.83027177
144Arnold-Chiari malformation (HP:0002308)1.82474175
145Malnutrition (HP:0004395)1.82350130
146Vertebral arch anomaly (HP:0008438)1.81888843
147Hypophosphatemic rickets (HP:0004912)1.81811205
148Cerebral inclusion bodies (HP:0100314)1.81646315
149Abnormality of proline metabolism (HP:0010907)1.80847611
150Hydroxyprolinuria (HP:0003080)1.80847611
151Insidious onset (HP:0003587)1.80020594
152Termporal pattern (HP:0011008)1.80020594
153Ulnar bowing (HP:0003031)1.79922968
154Cardiovascular calcification (HP:0011915)1.79553662
155Infantile muscular hypotonia (HP:0008947)1.79492103
156Fragile skin (HP:0001030)1.78130989
157Abnormality of vitamin metabolism (HP:0100508)1.77840406
158Vomiting (HP:0002013)1.76976312
159Spinal rigidity (HP:0003306)1.76730711
160Calcaneovalgus deformity (HP:0001848)1.75590051
161Joint laxity (HP:0001388)1.75038111
162Elfin facies (HP:0004428)1.74383015
163Germ cell neoplasia (HP:0100728)1.73462180
164Gingival bleeding (HP:0000225)1.73123077
165Spastic paraparesis (HP:0002313)1.73082896
166Spinal cord compression (HP:0002176)1.73035028
167Focal dystonia (HP:0004373)1.73015595
168Lymphangioma (HP:0100764)1.71922809
169Pheochromocytoma (HP:0002666)1.71678111
170Esophageal varix (HP:0002040)1.71491742
171Hyperinsulinemic hypoglycemia (HP:0000825)1.69446668
172Akinesia (HP:0002304)1.68808119
173Pancreatitis (HP:0001733)1.68047624
174Recurrent gram-negative bacterial infections (HP:0005420)1.66291273
175Macroorchidism (HP:0000053)1.65283123
176Abnormality of the Achilles tendon (HP:0005109)1.64938995
177Broad face (HP:0000283)1.64045014
178Midline defect of the nose (HP:0004122)1.63980520
179Thrombophlebitis (HP:0004418)1.63814204
180Insomnia (HP:0100785)1.62878083
181Megalocornea (HP:0000485)1.62843597
182Morphological abnormality of the pyramidal tract (HP:0002062)1.61778570
183Paraparesis (HP:0002385)1.61637571
184Alkalosis (HP:0001948)1.61574615
185Hemorrhage of the eye (HP:0011885)1.60820422
186Hammertoe (HP:0001765)1.60533013
187Hyporeflexia of lower limbs (HP:0002600)1.60527226
188Blue sclerae (HP:0000592)1.59065211
189Camptodactyly of toe (HP:0001836)1.58757127
190Aplasia involving bones of the extremities (HP:0009825)1.58724495
191Aplasia involving bones of the upper limbs (HP:0009823)1.58724495
192Aplasia of the phalanges of the hand (HP:0009802)1.58724495
193Neoplasm of the heart (HP:0100544)1.56966600
194Bicornuate uterus (HP:0000813)1.56746172
195Peritonitis (HP:0002586)1.56529703
196Short nail (HP:0001799)1.55446623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.18831162
2SCYL23.64792013
3MUSK3.58996955
4SIK13.30647877
5FGFR43.29232947
6ERN12.91782670
7ERBB42.84677495
8PIK3CA2.75956729
9MAP2K42.66870866
10FGFR22.53519372
11EPHA42.34190583
12EEF2K2.08136091
13INSRR1.99486911
14WNK31.83510034
15EPHA31.79953451
16LMTK21.71152290
17KSR21.69069129
18RPS6KB21.67680208
19NEK61.60761929
20ERBB21.59539225
21MAP3K41.57008095
22RET1.55435589
23RPS6KA21.54822756
24NTRK31.54530900
25MAPKAPK31.47970586
26TTN1.46785741
27MINK11.44054027
28PHKG21.42391678
29PHKG11.42391678
30TRIB31.41752809
31NTRK21.37947272
32ICK1.35764559
33PAK31.34875636
34NTRK11.34238093
35CSNK1G21.33875578
36MYLK1.33755113
37MARK11.31050280
38PAK61.28403920
39PNCK1.28229680
40CSNK1G31.24619900
41PKN21.22798906
42IRAK21.20419555
43RIPK11.20086186
44MTOR1.18995447
45MAP3K91.18719719
46MAPK111.17795896
47RPS6KB11.17543607
48CHUK1.16212353
49MAP3K131.14278252
50DAPK21.13518014
51SGK2231.12972385
52SGK4941.12972385
53CSNK1G11.12306086
54KSR11.11404895
55LATS21.10285418
56PAK21.07676053
57EPHB11.06020666
58ILK1.05001444
59MAP3K71.04211610
60GRK61.00834356
61EPHB20.99975669
62PRKCZ0.97510663
63SMG10.96746571
64MAP2K20.95388997
65PINK10.93993737
66TYRO30.89998792
67PRKCG0.89580044
68MAP3K120.89493074
69TAOK30.89016706
70PIK3CG0.86426207
71TESK10.86144238
72PDGFRA0.85939074
73PKN10.85388530
74CAMK2G0.84831956
75MAPK40.82263297
76CAMK1G0.81180276
77MAP3K100.80650885
78PTK60.79765315
79STK390.78993198
80SGK30.78374555
81EPHA20.77622040
82LIMK10.76337787
83ABL20.76114733
84ROCK20.76022328
85LATS10.75828345
86PDGFRB0.74360972
87MAP2K70.73973165
88DYRK20.72948584
89MAP2K10.72717326
90MST1R0.72349133
91CAMK2D0.71289112
92PRKCH0.70087354
93CAMK1D0.69667886
94CAMKK10.69217078
95SGK20.68944208
96FER0.68619825
97CDK11A0.68259205
98CSNK1A1L0.68189809
99BRD40.68040095
100CDK50.67794140
101PTK20.66381252
102ARAF0.66340137
103RPS6KL10.65810968
104RPS6KC10.65810968
105TRPM70.65331233
106MET0.63445741
107IRAK10.61445876
108JAK20.60770277
109CASK0.60130093
110PRKD30.59887024
111WNK40.59817625
112CAMK2A0.59528654
113MAP3K20.59500380
114PDPK10.59098882
115PRKAA20.58766539
116PRKACG0.58650931
117CDK70.56969129
118PAK40.56955597
119MAPK130.56670031
120BCR0.56386397
121MAPK120.54312496
122ROCK10.53234815
123RPS6KA60.52369804
124UHMK10.52225574
125PRKCQ0.52067457
126DYRK1B0.49357077
127SIK20.49093243
128RPS6KA40.49039205
129OXSR10.48302122
130MAPK70.47981695
131FRK0.47219246
132MOS0.47149068
133FGFR10.44247484
134PRKAA10.43103565
135CSNK1D0.42993356
136DDR20.40912539
137DAPK30.39858010
138MAP3K60.39302588
139CLK10.38728058
140CAMK2B0.38179107
141TAF10.38164682
142MAPK80.37928473
143MARK20.37455250
144DYRK1A0.37380040
145PRKD20.37379739
146PRKCI0.37075122
147CDK140.36857199
148CDK150.35901455
149CDK180.35526625

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56146785
2Nitrogen metabolism_Homo sapiens_hsa009103.99760208
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.49392193
4Arginine biosynthesis_Homo sapiens_hsa002203.16386664
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05960784
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.01372298
7Complement and coagulation cascades_Homo sapiens_hsa046102.72544740
8Tryptophan metabolism_Homo sapiens_hsa003802.64534765
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51953492
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45850852
11Fatty acid degradation_Homo sapiens_hsa000712.43434437
12Butanoate metabolism_Homo sapiens_hsa006502.29633762
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27824005
14ECM-receptor interaction_Homo sapiens_hsa045122.08017398
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03817275
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99314373
17Peroxisome_Homo sapiens_hsa041461.96129651
18Fatty acid metabolism_Homo sapiens_hsa012121.93060504
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.89734566
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89461316
21PPAR signaling pathway_Homo sapiens_hsa033201.85933183
22Propanoate metabolism_Homo sapiens_hsa006401.81672169
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80945911
24Histidine metabolism_Homo sapiens_hsa003401.80453932
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.79523359
26Endometrial cancer_Homo sapiens_hsa052131.75077325
27Chemical carcinogenesis_Homo sapiens_hsa052041.70501528
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64272297
29Bile secretion_Homo sapiens_hsa049761.60236200
30Thyroid cancer_Homo sapiens_hsa052161.59993116
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.59796091
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58031685
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.57540513
34Focal adhesion_Homo sapiens_hsa045101.55985147
35Phenylalanine metabolism_Homo sapiens_hsa003601.55463831
36Dilated cardiomyopathy_Homo sapiens_hsa054141.53791573
37Fatty acid elongation_Homo sapiens_hsa000621.52745194
38Retinol metabolism_Homo sapiens_hsa008301.52349927
39beta-Alanine metabolism_Homo sapiens_hsa004101.51203384
40Glioma_Homo sapiens_hsa052141.49454417
41Tyrosine metabolism_Homo sapiens_hsa003501.44804207
42Steroid biosynthesis_Homo sapiens_hsa001001.44672414
43Melanoma_Homo sapiens_hsa052181.44207920
44Hippo signaling pathway_Homo sapiens_hsa043901.44121071
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.42806935
46ErbB signaling pathway_Homo sapiens_hsa040121.42763672
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42280197
48Estrogen signaling pathway_Homo sapiens_hsa049151.41990965
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41514577
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.40832520
51Staphylococcus aureus infection_Homo sapiens_hsa051501.40398892
52Caffeine metabolism_Homo sapiens_hsa002321.37980754
53Tight junction_Homo sapiens_hsa045301.36326620
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.36309857
55Pyruvate metabolism_Homo sapiens_hsa006201.34468035
56Proteoglycans in cancer_Homo sapiens_hsa052051.34295285
57Renal cell carcinoma_Homo sapiens_hsa052111.34163169
58Gap junction_Homo sapiens_hsa045401.32227086
59Sulfur metabolism_Homo sapiens_hsa009201.32132485
60mTOR signaling pathway_Homo sapiens_hsa041501.31014462
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27504049
62Cholinergic synapse_Homo sapiens_hsa047251.25796920
63Selenocompound metabolism_Homo sapiens_hsa004501.23177464
64Melanogenesis_Homo sapiens_hsa049161.22567152
65Basal cell carcinoma_Homo sapiens_hsa052171.22219884
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21626985
67Chronic myeloid leukemia_Homo sapiens_hsa052201.21348066
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.21171451
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20564847
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17392340
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16085342
72Biosynthesis of amino acids_Homo sapiens_hsa012301.15661790
73Starch and sucrose metabolism_Homo sapiens_hsa005001.14722732
74Notch signaling pathway_Homo sapiens_hsa043301.13207867
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12506663
76Choline metabolism in cancer_Homo sapiens_hsa052311.11699037
77Prolactin signaling pathway_Homo sapiens_hsa049171.08627778
78Circadian entrainment_Homo sapiens_hsa047131.07788941
79Neurotrophin signaling pathway_Homo sapiens_hsa047221.07151363
80MicroRNAs in cancer_Homo sapiens_hsa052061.05497760
81Hedgehog signaling pathway_Homo sapiens_hsa043401.04790067
82Non-small cell lung cancer_Homo sapiens_hsa052231.04682546
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04524301
84Bladder cancer_Homo sapiens_hsa052191.04149458
85Adherens junction_Homo sapiens_hsa045201.04015194
86Protein digestion and absorption_Homo sapiens_hsa049741.03378789
87ABC transporters_Homo sapiens_hsa020101.00857024
88Fat digestion and absorption_Homo sapiens_hsa049751.00054873
89Carbon metabolism_Homo sapiens_hsa012000.99004677
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98676704
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.98473947
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98354396
93Amoebiasis_Homo sapiens_hsa051460.94997388
94Prostate cancer_Homo sapiens_hsa052150.92493238
95VEGF signaling pathway_Homo sapiens_hsa043700.90402633
96TGF-beta signaling pathway_Homo sapiens_hsa043500.89988540
97Arginine and proline metabolism_Homo sapiens_hsa003300.89344550
98Folate biosynthesis_Homo sapiens_hsa007900.89107674
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87632921
100Wnt signaling pathway_Homo sapiens_hsa043100.86794586
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.86351176
102Colorectal cancer_Homo sapiens_hsa052100.85004005
103Long-term potentiation_Homo sapiens_hsa047200.84684839
104Vitamin B6 metabolism_Homo sapiens_hsa007500.84430352
105Small cell lung cancer_Homo sapiens_hsa052220.83670749
106Long-term depression_Homo sapiens_hsa047300.81206456
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.78454271
108Lysine degradation_Homo sapiens_hsa003100.77650903
109Rap1 signaling pathway_Homo sapiens_hsa040150.76725500
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74252967
111Fatty acid biosynthesis_Homo sapiens_hsa000610.71621554
112Inositol phosphate metabolism_Homo sapiens_hsa005620.70526394
113Vibrio cholerae infection_Homo sapiens_hsa051100.70420723
114Sulfur relay system_Homo sapiens_hsa041220.70286735
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70223100
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68803531
117Pathways in cancer_Homo sapiens_hsa052000.68026692
118Glycerolipid metabolism_Homo sapiens_hsa005610.67641863
119Alcoholism_Homo sapiens_hsa050340.67453878
120Vitamin digestion and absorption_Homo sapiens_hsa049770.67127678
121Oxytocin signaling pathway_Homo sapiens_hsa049210.65559535
122Gastric acid secretion_Homo sapiens_hsa049710.64950219
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63864089
124Prion diseases_Homo sapiens_hsa050200.62953247
125Acute myeloid leukemia_Homo sapiens_hsa052210.62941803
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62600593
127Pancreatic cancer_Homo sapiens_hsa052120.60363773
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59735670
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58814442
130GnRH signaling pathway_Homo sapiens_hsa049120.57427904
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54622707
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53626621
133Ras signaling pathway_Homo sapiens_hsa040140.51466088
134cAMP signaling pathway_Homo sapiens_hsa040240.50821246
135FoxO signaling pathway_Homo sapiens_hsa040680.50175387
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.48125453
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45594993
138Glutathione metabolism_Homo sapiens_hsa004800.44253603
139Pentose phosphate pathway_Homo sapiens_hsa000300.39190099
140Metabolic pathways_Homo sapiens_hsa011000.38138511
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32583424
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.28852493
143Glucagon signaling pathway_Homo sapiens_hsa049220.24991025
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.23763313
145One carbon pool by folate_Homo sapiens_hsa006700.23510217
146Insulin resistance_Homo sapiens_hsa049310.23489485
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16402930
148Cocaine addiction_Homo sapiens_hsa050300.11656030
149GABAergic synapse_Homo sapiens_hsa047270.11313106
150AMPK signaling pathway_Homo sapiens_hsa041520.10108644
151Linoleic acid metabolism_Homo sapiens_hsa005910.08323049
152Insulin signaling pathway_Homo sapiens_hsa049100.03120188
153Ovarian steroidogenesis_Homo sapiens_hsa049130.02625545
154Axon guidance_Homo sapiens_hsa043600.02604795
155Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.1413291
156Ether lipid metabolism_Homo sapiens_hsa00565-0.1369083
157Amphetamine addiction_Homo sapiens_hsa05031-0.1298067
158Type II diabetes mellitus_Homo sapiens_hsa04930-0.1283753
159Glutamatergic synapse_Homo sapiens_hsa04724-0.1135436
160Dopaminergic synapse_Homo sapiens_hsa04728-0.1133983
161Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1094657
162Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1053533
163Insulin secretion_Homo sapiens_hsa04911-0.1042522
164Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0823948
165Nicotine addiction_Homo sapiens_hsa05033-0.0551321
166Regulation of autophagy_Homo sapiens_hsa04140-0.0520278
167Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0426884
168Synaptic vesicle cycle_Homo sapiens_hsa04721-0.0372250
169Galactose metabolism_Homo sapiens_hsa00052-0.0330849
170Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0198552
171Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0115339
172Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0057659

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