GFRA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.14878583
2enteric nervous system development (GO:0048484)5.58194796
3glutamate secretion (GO:0014047)5.36194980
4neuronal action potential propagation (GO:0019227)5.35636452
5synaptic vesicle exocytosis (GO:0016079)5.23198792
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.11282871
7neuron cell-cell adhesion (GO:0007158)4.91075768
8protein localization to synapse (GO:0035418)4.85078712
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.82888316
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.81409263
11synaptic vesicle maturation (GO:0016188)4.74592098
12regulation of synaptic vesicle exocytosis (GO:2000300)4.69718709
13vocalization behavior (GO:0071625)4.67611864
14locomotory exploration behavior (GO:0035641)4.66390019
15sympathetic nervous system development (GO:0048485)4.60933951
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56814528
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.51485086
18sodium ion export (GO:0071436)4.28921173
19negative regulation of dendrite morphogenesis (GO:0050774)4.28554064
20presynaptic membrane assembly (GO:0097105)4.20203255
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17963461
22L-amino acid import (GO:0043092)4.16102614
23regulation of glutamate receptor signaling pathway (GO:1900449)4.15246182
24regulation of synapse structural plasticity (GO:0051823)4.14764647
25positive regulation of dendritic spine morphogenesis (GO:0061003)4.12499624
26regulation of respiratory gaseous exchange (GO:0043576)4.08775947
27regulation of synaptic vesicle transport (GO:1902803)4.03703205
28behavioral response to nicotine (GO:0035095)4.02127572
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.99744711
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.94637040
31cerebellar granule cell differentiation (GO:0021707)3.94119286
32positive regulation of dendritic spine development (GO:0060999)3.91217323
33presynaptic membrane organization (GO:0097090)3.89814481
34exploration behavior (GO:0035640)3.89160167
35membrane depolarization during action potential (GO:0086010)3.88879603
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.85584343
37positive regulation of synaptic transmission, GABAergic (GO:0032230)3.82462066
38synaptic transmission, glutamatergic (GO:0035249)3.81010916
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.75581839
40ganglion development (GO:0061548)3.74894713
41glutamate receptor signaling pathway (GO:0007215)3.70433346
42neuron-neuron synaptic transmission (GO:0007270)3.65170453
43behavioral response to pain (GO:0048266)3.65051771
44neuronal action potential (GO:0019228)3.64204643
45proline transport (GO:0015824)3.64177760
46cell migration in hindbrain (GO:0021535)3.59437633
47postsynaptic membrane organization (GO:0001941)3.59392312
48cell differentiation in hindbrain (GO:0021533)3.57953815
49neurotransmitter secretion (GO:0007269)3.57646196
50regulation of respiratory system process (GO:0044065)3.51396318
51regulation of neurotransmitter secretion (GO:0046928)3.50364881
52urinary tract smooth muscle contraction (GO:0014848)3.48463601
53negative regulation of dendrite development (GO:2000171)3.48030725
54neuron recognition (GO:0008038)3.47357818
55phosphorelay signal transduction system (GO:0000160)3.46077309
56short-term memory (GO:0007614)3.45306735
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44369354
58regulation of dendrite morphogenesis (GO:0048814)3.43866320
59auditory behavior (GO:0031223)3.43453882
60axonal fasciculation (GO:0007413)3.43252061
61neuromuscular process controlling balance (GO:0050885)3.40842135
62adult walking behavior (GO:0007628)3.38626220
63pyrimidine nucleobase catabolic process (GO:0006208)3.37987983
64negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.36889850
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.36336203
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34172630
67regulation of postsynaptic membrane potential (GO:0060078)3.34076566
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.33090615
69membrane depolarization (GO:0051899)3.31804222
70neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.30547543
71cerebellar Purkinje cell differentiation (GO:0021702)3.30416557
72amino acid import (GO:0043090)3.29648417
73innervation (GO:0060384)3.28537629
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28492544
75regulation of neuronal synaptic plasticity (GO:0048168)3.20615878
76regulation of synapse maturation (GO:0090128)3.19087573
77synaptic vesicle endocytosis (GO:0048488)3.15040929
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14855215
79layer formation in cerebral cortex (GO:0021819)3.13344565
80cell communication by electrical coupling (GO:0010644)3.11385992
81cellular potassium ion homeostasis (GO:0030007)3.10510051
82regulation of vesicle fusion (GO:0031338)3.10374085
83regulation of synaptic transmission, glutamatergic (GO:0051966)3.10245339
84response to auditory stimulus (GO:0010996)3.07717158
85dendritic spine organization (GO:0097061)3.06510483
86neuromuscular process controlling posture (GO:0050884)3.05667235
87regulation of neurotransmitter transport (GO:0051588)3.04044885
88neurotransmitter-gated ion channel clustering (GO:0072578)3.03984076
89positive regulation of membrane potential (GO:0045838)3.03862323
90regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03581579
91retinal cone cell development (GO:0046549)3.03169442
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02796746
93cellular sodium ion homeostasis (GO:0006883)3.02461848
94neuromuscular process (GO:0050905)3.02043698
95transmission of nerve impulse (GO:0019226)3.01388599
96establishment of mitochondrion localization (GO:0051654)3.00299354
97membrane hyperpolarization (GO:0060081)3.00219406
98positive regulation of neurotransmitter secretion (GO:0001956)2.97598786
99positive regulation of synapse assembly (GO:0051965)2.97536096
100dendritic spine morphogenesis (GO:0060997)2.94974819
101regulation of synaptic plasticity (GO:0048167)2.94963460
102neurotransmitter transport (GO:0006836)2.93936359
103long-term synaptic potentiation (GO:0060291)2.93094388
104activation of protein kinase A activity (GO:0034199)2.90667064
105calcium ion-dependent exocytosis (GO:0017156)2.90597914
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90310572
107vesicle transport along microtubule (GO:0047496)2.89453753
108gamma-aminobutyric acid transport (GO:0015812)2.88388165
109regulation of voltage-gated calcium channel activity (GO:1901385)2.87534399
110synaptic transmission (GO:0007268)2.86209684
111positive regulation of synapse maturation (GO:0090129)2.85925780
112mating behavior (GO:0007617)2.85618984
113negative regulation of cation channel activity (GO:2001258)2.82601022
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81710982
115neuronal ion channel clustering (GO:0045161)2.81278529
116membrane assembly (GO:0071709)2.80572814
117response to pain (GO:0048265)2.79811847
118neuromuscular synaptic transmission (GO:0007274)2.79759990
119regulation of dendritic spine morphogenesis (GO:0061001)2.79215971
120regulation of synapse assembly (GO:0051963)2.76825137
121negative regulation of calcium ion transport into cytosol (GO:0010523)2.75554084
122regulation of glutamate secretion (GO:0014048)2.75352187
123retinal ganglion cell axon guidance (GO:0031290)2.72294205
124detection of calcium ion (GO:0005513)2.70049350
125membrane repolarization (GO:0086009)2.69661767
126long-term memory (GO:0007616)2.69139916
127regulation of neurotransmitter levels (GO:0001505)2.69033927
128regulation of synaptic transmission, GABAergic (GO:0032228)2.68984643
129positive regulation of synaptic transmission (GO:0050806)2.68781374
130positive regulation of neurotransmitter transport (GO:0051590)2.68586174
131synapse assembly (GO:0007416)2.68316778
132regulation of synaptic transmission (GO:0050804)2.67156918
133sensory perception of pain (GO:0019233)2.65976899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.52254178
2GBX2_23144817_ChIP-Seq_PC3_Human3.83590395
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17274149
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16663522
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09893413
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82443554
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82443554
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82390631
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.70524396
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69570676
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.69091098
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.64390420
13TAF15_26573619_Chip-Seq_HEK293_Human2.58206377
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51060017
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44629120
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39195263
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35654758
18REST_21632747_ChIP-Seq_MESCs_Mouse2.30555208
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26681591
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.21871048
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.19789416
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19137517
23* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98724283
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94102555
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93044619
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91102864
27AR_21572438_ChIP-Seq_LNCaP_Human1.89495681
28DROSHA_22980978_ChIP-Seq_HELA_Human1.89124662
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.86947333
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81221855
31P300_19829295_ChIP-Seq_ESCs_Human1.79647190
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.77936107
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75623390
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.75038297
35* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73255330
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71790691
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70975620
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.66828773
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66435965
40* CBX2_27304074_Chip-Seq_ESCs_Mouse1.59940722
41* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56584201
42* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55025602
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44949228
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44297904
45RNF2_27304074_Chip-Seq_NSC_Mouse1.41417616
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40758209
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.37066187
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35547697
49* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34763258
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34357653
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34063535
52AR_25329375_ChIP-Seq_VCAP_Human1.33525046
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31265551
54GATA1_22025678_ChIP-Seq_K562_Human1.29372921
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.28858808
56* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28260077
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.28084998
58* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28008025
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26725253
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.25877059
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.25051893
62AHR_22903824_ChIP-Seq_MCF-7_Human1.22452118
63* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21997500
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20937217
65VDR_22108803_ChIP-Seq_LS180_Human1.19106168
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18324760
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18324760
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17561856
69* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16897519
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16345638
71TP53_18474530_ChIP-ChIP_U2OS_Human1.15827927
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.15079850
73* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13774993
74STAT3_23295773_ChIP-Seq_U87_Human1.13764018
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13739863
76KDM2B_26808549_Chip-Seq_K562_Human1.12021984
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11966980
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11788212
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11622374
80* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10967704
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09961852
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07222038
83* TCF4_23295773_ChIP-Seq_U87_Human1.06996114
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06393888
85* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06253834
86* RING1B_27294783_Chip-Seq_NPCs_Mouse1.05971723
87* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05439005
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05054772
89* AR_19668381_ChIP-Seq_PC3_Human1.04551575
90BCAT_22108803_ChIP-Seq_LS180_Human1.04283483
91FUS_26573619_Chip-Seq_HEK293_Human1.04139629
92ZNF274_21170338_ChIP-Seq_K562_Hela1.04101757
93* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03530313
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.02192677
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.02042430
96* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00455567
97* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00058275
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99938816
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99916331
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99266396
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.98608636
102JUN_21703547_ChIP-Seq_K562_Human0.97625126
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96658669
104* TP53_20018659_ChIP-ChIP_R1E_Mouse0.95758789
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95089274
106* KDM2B_26808549_Chip-Seq_REH_Human0.95071504
107* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94991829
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94766035
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.90559960
110ER_23166858_ChIP-Seq_MCF-7_Human0.90501781
111E2F1_18555785_Chip-Seq_ESCs_Mouse0.89648796
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88995303
113* TET1_21490601_ChIP-Seq_MESCs_Mouse0.88285848
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86497777
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86144188
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86002235
117DPY_21335234_ChIP-Seq_ESCs_Mouse0.84826076
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.84742780
119CTCF_27219007_Chip-Seq_Bcells_Human0.84447743
120* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82834599
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81398960
122IGF1R_20145208_ChIP-Seq_DFB_Human0.80712351
123* SOX9_26525672_Chip-Seq_HEART_Mouse0.78698765
124FLI1_21867929_ChIP-Seq_TH2_Mouse0.78489668
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77587972
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76940298
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76140649
128* TAL1_26923725_Chip-Seq_HPCs_Mouse0.76049999
129OCT4_19829295_ChIP-Seq_ESCs_Human0.75845964
130SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.74440775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception5.25460814
2MP0004859_abnormal_synaptic_plasticity5.09599757
3MP0003880_abnormal_central_pattern4.61061526
4MP0002736_abnormal_nociception_after4.59621425
5MP0002735_abnormal_chemical_nociception4.26481926
6MP0004270_analgesia3.51190951
7MP0003635_abnormal_synaptic_transmissio3.43337620
8MP0002734_abnormal_mechanical_nocicepti3.29880025
9MP0002733_abnormal_thermal_nociception2.86834626
10MP0009745_abnormal_behavioral_response2.84686991
11MP0005423_abnormal_somatic_nervous2.79575053
12MP0006276_abnormal_autonomic_nervous2.74624563
13MP0001970_abnormal_pain_threshold2.74440137
14MP0002063_abnormal_learning/memory/cond2.67356167
15MP0003122_maternal_imprinting2.66744286
16* MP0002064_seizures2.65427971
17MP0009046_muscle_twitch2.53157958
18MP0002572_abnormal_emotion/affect_behav2.49315733
19MP0002272_abnormal_nervous_system2.47712608
20MP0002067_abnormal_sensory_capabilities2.29171407
21MP0009780_abnormal_chondrocyte_physiolo2.28462505
22MP0001986_abnormal_taste_sensitivity2.20475427
23MP0001440_abnormal_grooming_behavior2.13721641
24MP0002184_abnormal_innervation2.09263468
25MP0001486_abnormal_startle_reflex2.04579733
26MP0004858_abnormal_nervous_system1.96787719
27MP0005645_abnormal_hypothalamus_physiol1.80837705
28MP0001501_abnormal_sleep_pattern1.79899780
29MP0008877_abnormal_DNA_methylation1.65052169
30MP0000778_abnormal_nervous_system1.64713568
31MP0001984_abnormal_olfaction1.59700681
32MP0002557_abnormal_social/conspecific_i1.58051049
33MP0004811_abnormal_neuron_physiology1.54913370
34MP0003879_abnormal_hair_cell1.54240028
35MP0005646_abnormal_pituitary_gland1.49231449
36MP0000955_abnormal_spinal_cord1.40633868
37MP0008569_lethality_at_weaning1.35555919
38MP0003690_abnormal_glial_cell1.32940393
39MP0001905_abnormal_dopamine_level1.31044694
40MP0005386_behavior/neurological_phenoty1.30163473
41MP0004924_abnormal_behavior1.30163473
42MP0001188_hyperpigmentation1.27013748
43* MP0002882_abnormal_neuron_morphology1.25990009
44MP0003121_genomic_imprinting1.18866153
45MP0002066_abnormal_motor_capabilities/c1.17626272
46MP0001502_abnormal_circadian_rhythm1.13438433
47MP0002163_abnormal_gland_morphology1.11188490
48MP0000751_myopathy1.08803396
49MP0003787_abnormal_imprinting1.08330259
50MP0005171_absent_coat_pigmentation1.05158605
51MP0004142_abnormal_muscle_tone1.05009825
52MP0003329_amyloid_beta_deposits1.04796760
53MP0002102_abnormal_ear_morphology1.02857720
54MP0002876_abnormal_thyroid_physiology1.01075502
55MP0003632_abnormal_nervous_system0.98388190
56MP0004742_abnormal_vestibular_system0.97200298
57MP0001529_abnormal_vocalization0.96627756
58MP0010386_abnormal_urinary_bladder0.96128124
59MP0003633_abnormal_nervous_system0.95943464
60MP0001177_atelectasis0.94590487
61MP0000604_amyloidosis0.93735050
62MP0005167_abnormal_blood-brain_barrier0.93215635
63MP0008874_decreased_physiological_sensi0.92474455
64MP0004885_abnormal_endolymph0.91079698
65MP0004145_abnormal_muscle_electrophysio0.88134709
66* MP0002751_abnormal_autonomic_nervous0.87995591
67MP0002752_abnormal_somatic_nervous0.85149342
68MP0002152_abnormal_brain_morphology0.84060898
69MP0001485_abnormal_pinna_reflex0.83968773
70MP0005187_abnormal_penis_morphology0.82620759
71MP0004484_altered_response_of0.80754679
72MP0002909_abnormal_adrenal_gland0.80625484
73MP0001963_abnormal_hearing_physiology0.79074736
74MP0003631_nervous_system_phenotype0.78972679
75MP0002837_dystrophic_cardiac_calcinosis0.78616779
76MP0002638_abnormal_pupillary_reflex0.78360769
77MP0003861_abnormal_nervous_system0.78157488
78MP0005379_endocrine/exocrine_gland_phen0.75688540
79MP0003183_abnormal_peptide_metabolism0.75146678
80MP0003567_abnormal_fetal_cardiomyocyte0.72910743
81MP0000534_abnormal_ureter_morphology0.72880576
82MP0000631_abnormal_neuroendocrine_gland0.71959261
83MP0001270_distended_abdomen0.69286506
84* MP0002069_abnormal_eating/drinking_beha0.69026744
85MP0005551_abnormal_eye_electrophysiolog0.66290035
86MP0003045_fibrosis0.66016354
87MP0004085_abnormal_heartbeat0.65922279
88MP0000569_abnormal_digit_pigmentation0.65787820
89MP0002229_neurodegeneration0.65720117
90MP0008872_abnormal_physiological_respon0.65470075
91MP0003123_paternal_imprinting0.65217540
92MP0005409_darkened_coat_color0.63724243
93MP0003137_abnormal_impulse_conducting0.62424914
94MP0002090_abnormal_vision0.61042602
95MP0001943_abnormal_respiration0.59926736
96MP0010768_mortality/aging0.59894522
97MP0001299_abnormal_eye_distance/0.59125805
98MP0003634_abnormal_glial_cell0.58700598
99MP0000681_abnormal_thyroid_gland0.58555147
100MP0005535_abnormal_body_temperature0.57673057
101MP0005623_abnormal_meninges_morphology0.57165824
102MP0003075_altered_response_to0.55895999
103MP0005503_abnormal_tendon_morphology0.54261860
104MP0009379_abnormal_foot_pigmentation0.53971969
105MP0002822_catalepsy0.52847523
106MP0005394_taste/olfaction_phenotype0.51281358
107MP0005499_abnormal_olfactory_system0.51281358
108MP0002653_abnormal_ependyma_morphology0.51046994
109MP0004510_myositis0.50802933
110MP0008004_abnormal_stomach_pH0.50251519
111MP0003011_delayed_dark_adaptation0.49636480
112* MP0001664_abnormal_digestion0.49090650
113* MP0005253_abnormal_eye_physiology0.47998069
114MP0000026_abnormal_inner_ear0.47872245
115* MP0003956_abnormal_body_size0.45429849
116MP0008260_abnormal_autophagy0.44663139
117MP0002082_postnatal_lethality0.44004834
118MP0010770_preweaning_lethality0.44004834
119MP0002161_abnormal_fertility/fecundity0.43946758
120MP0001731_abnormal_postnatal_growth0.43808765
121MP0000538_abnormal_urinary_bladder0.43106182
122MP0000920_abnormal_myelination0.42478735
123MP0002081_perinatal_lethality0.42410885
124MP0010769_abnormal_survival0.42204456
125MP0000049_abnormal_middle_ear0.42137089
126MP0003698_abnormal_male_reproductive0.41944501

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.85987608
2Myokymia (HP:0002411)6.82806036
3Febrile seizures (HP:0002373)5.94177317
4Focal seizures (HP:0007359)5.77296518
5Atonic seizures (HP:0010819)5.68942622
6Epileptic encephalopathy (HP:0200134)5.03896915
7Progressive cerebellar ataxia (HP:0002073)4.69946699
8Absence seizures (HP:0002121)4.41519745
9Visual hallucinations (HP:0002367)4.16765829
10Dialeptic seizures (HP:0011146)4.03990861
11Generalized tonic-clonic seizures (HP:0002069)3.81088899
12Termporal pattern (HP:0011008)3.78075070
13Insidious onset (HP:0003587)3.78075070
14Ulnar claw (HP:0001178)3.75344736
15Action tremor (HP:0002345)3.62398782
16Annular pancreas (HP:0001734)3.60255774
17Spastic gait (HP:0002064)3.58409414
18Hyperventilation (HP:0002883)3.56757493
19Apathy (HP:0000741)3.54762369
20Neurofibrillary tangles (HP:0002185)3.43635664
21Abnormal hair whorl (HP:0010721)3.32424589
22Diminished motivation (HP:0000745)3.27934828
23Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.20531731
24Asymmetry of the thorax (HP:0001555)3.20445789
25Broad-based gait (HP:0002136)3.10816812
26Hypoventilation (HP:0002791)3.07311420
27Intention tremor (HP:0002080)3.04807236
28Gaze-evoked nystagmus (HP:0000640)2.99893342
29Truncal ataxia (HP:0002078)2.93400978
30Amblyopia (HP:0000646)2.93030829
31Neuronal loss in central nervous system (HP:0002529)2.85504391
32Failure to thrive in infancy (HP:0001531)2.84784700
33Agnosia (HP:0010524)2.81235817
34Limb dystonia (HP:0002451)2.79483441
35Peripheral hypomyelination (HP:0007182)2.76046255
36Pheochromocytoma (HP:0002666)2.73049960
37Cerebral inclusion bodies (HP:0100314)2.61654058
38Abnormal eating behavior (HP:0100738)2.59436834
39Diplopia (HP:0000651)2.55149406
40Abnormality of binocular vision (HP:0011514)2.55149406
41Neuroendocrine neoplasm (HP:0100634)2.54279345
42Polyphagia (HP:0002591)2.52365765
43Poor eye contact (HP:0000817)2.50817656
44Absent speech (HP:0001344)2.46921398
45Delusions (HP:0000746)2.45957876
46Lower limb muscle weakness (HP:0007340)2.44010683
47Impaired pain sensation (HP:0007328)2.42742312
48Abnormality of pain sensation (HP:0010832)2.42742312
49Inappropriate behavior (HP:0000719)2.41121891
50Supranuclear gaze palsy (HP:0000605)2.40504411
51Sensory axonal neuropathy (HP:0003390)2.40457421
52Status epilepticus (HP:0002133)2.37673606
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.35212329
54Absent/shortened dynein arms (HP:0200106)2.35212329
55Cerebral hypomyelination (HP:0006808)2.34681263
56Narrow nasal bridge (HP:0000446)2.32309388
57Urinary bladder sphincter dysfunction (HP:0002839)2.31690839
58Akinesia (HP:0002304)2.31239096
59Disinhibition (HP:0000734)2.30442847
60Myotonia (HP:0002486)2.29425018
61Amyotrophic lateral sclerosis (HP:0007354)2.29212499
62Hyperthyroidism (HP:0000836)2.28742733
63Supernumerary spleens (HP:0009799)2.26530303
64Inability to walk (HP:0002540)2.26339186
65Ankle clonus (HP:0011448)2.22696716
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22578888
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.22578888
68Postural tremor (HP:0002174)2.21740437
69Hypercortisolism (HP:0001578)2.21477460
70Submucous cleft hard palate (HP:0000176)2.20567648
71Drooling (HP:0002307)2.18679495
72Excessive salivation (HP:0003781)2.18679495
73Memory impairment (HP:0002354)2.18350142
74Abnormality of the labia minora (HP:0012880)2.17137787
75Impaired vibration sensation in the lower limbs (HP:0002166)2.16166246
76Impaired vibratory sensation (HP:0002495)2.15358568
77Cutaneous finger syndactyly (HP:0010554)2.14920432
78Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.14369754
79Anxiety (HP:0000739)2.13749180
80Intestinal atresia (HP:0011100)2.13625491
81Spastic tetraparesis (HP:0001285)2.13337859
82Depression (HP:0000716)2.10207278
83Steppage gait (HP:0003376)2.10072672
84Sleep apnea (HP:0010535)2.09979626
85Blue irides (HP:0000635)2.09296058
86Tubulointerstitial fibrosis (HP:0005576)2.08320505
87Turricephaly (HP:0000262)2.08103547
88EEG with generalized epileptiform discharges (HP:0011198)2.07428698
89Bradykinesia (HP:0002067)2.06886973
90Esophageal atresia (HP:0002032)2.06042248
91Popliteal pterygium (HP:0009756)2.05245982
92Craniofacial dystonia (HP:0012179)2.04961802
93Tetraplegia (HP:0002445)2.03441799
94Genital tract atresia (HP:0001827)2.02386709
95Scanning speech (HP:0002168)2.00658215
96Hypoplastic nipples (HP:0002557)1.99869137
97Torticollis (HP:0000473)1.98952008
98Papilledema (HP:0001085)1.98614078
99Impaired social interactions (HP:0000735)1.96721896
100Abnormal social behavior (HP:0012433)1.96721896
101Palpebral edema (HP:0100540)1.96177128
102Exotropia (HP:0000577)1.95742404
103Hypsarrhythmia (HP:0002521)1.95206607
104Abnormality of the lower motor neuron (HP:0002366)1.94298185
105Dysmetria (HP:0001310)1.94203376
106Protruding tongue (HP:0010808)1.93745728
107Hemiplegia (HP:0002301)1.93583352
108Gait imbalance (HP:0002141)1.93069314
109Hip dysplasia (HP:0001385)1.92327451
110Vaginal atresia (HP:0000148)1.91793851
111Clonus (HP:0002169)1.89933332
112Urinary urgency (HP:0000012)1.89166835
113Shawl scrotum (HP:0000049)1.89166149
114Abnormality of the vocal cords (HP:0008777)1.88963753
115Genetic anticipation (HP:0003743)1.87369064
116Medial flaring of the eyebrow (HP:0010747)1.86164178
117Neuroblastic tumors (HP:0004376)1.85392287
118Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.85392287
119Neuroblastoma (HP:0003006)1.85392287
120Primitive neuroectodermal tumor (HP:0030065)1.85392287
121Fetal akinesia sequence (HP:0001989)1.84443684
122Ventricular fibrillation (HP:0001663)1.83832124
123Epileptiform EEG discharges (HP:0011182)1.83541163
124Specific learning disability (HP:0001328)1.83382346
125Poor suck (HP:0002033)1.82996528
126Agitation (HP:0000713)1.82178518
127Nephrogenic diabetes insipidus (HP:0009806)1.81977504
128Mutism (HP:0002300)1.81541333
129Abnormality of ocular smooth pursuit (HP:0000617)1.79277875
130Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77757239
131Hypoplasia of the brainstem (HP:0002365)1.77757239
132Dysdiadochokinesis (HP:0002075)1.77565568
133Bradycardia (HP:0001662)1.76931812
134Absent eyebrow (HP:0002223)1.75022234
135Esotropia (HP:0000565)1.74194736
136Impaired smooth pursuit (HP:0007772)1.74112388
137Focal dystonia (HP:0004373)1.73944812
138Gait ataxia (HP:0002066)1.73932437
139Hammertoe (HP:0001765)1.73632779
140Abnormality of calcium-phosphate metabolism (HP:0100530)1.73129359
141Postural instability (HP:0002172)1.70894703
142Mask-like facies (HP:0000298)1.70603748
143Widely spaced teeth (HP:0000687)1.70574393
144Hemiparesis (HP:0001269)1.70322487
145Abnormality of the corticospinal tract (HP:0002492)1.69523065
146Chin dimple (HP:0010751)1.69477871
147J-shaped sella turcica (HP:0002680)1.68485622
148Cutaneous syndactyly (HP:0012725)1.68383687
149Abnormality of salivation (HP:0100755)1.67732089
150Stereotypic behavior (HP:0000733)1.67485689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.35013496
2NTRK33.97939395
3DAPK23.32190439
4EPHA43.31803450
5MAP3K93.30299628
6GRK52.86341816
7MAP3K122.69540612
8MAP3K42.66918186
9MAP2K72.45969270
10RIPK42.32739261
11MAPK132.10756056
12PLK22.09476661
13ARAF2.09458958
14MINK12.07907661
15CCNB12.02271229
16SIK21.97352293
17KSR21.96661624
18SIK31.94471408
19PAK61.88781941
20MAP2K41.74486346
21NTRK21.74180107
22DAPK11.65947524
23MARK11.65215581
24ALK1.64704809
25TYRO31.62882515
26MAP3K131.55958424
27NTRK11.52096710
28PTK2B1.41176229
29CDK191.35649686
30CDK51.27513902
31PKN11.23023811
32MAP3K21.22617144
33UHMK11.16284244
34RET1.14483093
35DDR21.13413005
36PRKD31.13401198
37CDK141.12320325
38TNIK1.11220910
39CSNK1G31.11133652
40SGK21.09409852
41CAMKK21.08584776
42MAP3K111.05628722
43MAPKAPK51.04998788
44PRKCG1.04636249
45CDK181.03315988
46PNCK1.03191274
47CSNK1A1L1.02419977
48SGK4941.02292215
49SGK2231.02292215
50CAMKK11.00296652
51ICK0.99932002
52LATS20.98824581
53CDK150.98434533
54PINK10.97312476
55KSR10.96700719
56FES0.94523868
57NEK60.93970153
58CAMK10.92561125
59DYRK20.90560150
60CAMK2A0.89444766
61PRPF4B0.88799492
62CDK11A0.87323866
63AKT30.82155371
64RIPK10.80410132
65LMTK20.76459175
66CSNK1G10.76242109
67RPS6KA20.73395210
68MAPK120.71796428
69BRAF0.68970243
70FER0.68826086
71CAMK2B0.68635293
72DYRK1B0.68633758
73TNK20.67833397
74OXSR10.65153306
75ADRBK10.64919725
76STK110.64840036
77MARK20.62164999
78PHKG20.61622361
79PHKG10.61622361
80SGK30.61171258
81MAP3K10.60733914
82SGK10.60093841
83PRKCE0.59577783
84PAK30.59462464
85BCR0.58994312
86NME10.55797197
87CAMK40.54968784
88BMPR20.54272864
89TAOK10.53937402
90FRK0.52143342
91DAPK30.51698042
92CSNK1D0.51600832
93MATK0.51551178
94MAP2K10.49903266
95DYRK1A0.48749453
96CAMK1G0.47616657
97MAPK40.47317646
98CAMK2G0.46435197
99MAPK100.46232960
100TRIM280.45901311
101CSNK1G20.45588251
102PRKG10.45551303
103CDK80.45312522
104FGR0.45254035
105PRKCH0.44089959
106FGFR20.43936350
107ADRBK20.43760440
108LIMK10.43723280
109PRKCZ0.43258758
110WNK10.42931992
111EPHB20.42906297
112RPS6KA30.42824922
113RAF10.41573920
114CSNK1E0.40965026
115STK380.40379284
116CAMK2D0.39546700
117MOS0.38754049
118INSRR0.37663154
119GRK70.37543025
120PDK10.35803431
121CDC42BPA0.35162387
122FYN0.35152012
123PRKACA0.34369776
124PDPK10.32766382
125BRSK10.31988041
126MAP3K70.30615230
127MAPK70.30281456
128MAPK80.28832969
129IRAK20.28226473
130WNK30.28150133

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.60429930
2Nicotine addiction_Homo sapiens_hsa050333.50134269
3Olfactory transduction_Homo sapiens_hsa047402.52324030
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51760915
5Taste transduction_Homo sapiens_hsa047422.43338378
6Long-term potentiation_Homo sapiens_hsa047202.40061921
7Morphine addiction_Homo sapiens_hsa050322.38807318
8Circadian entrainment_Homo sapiens_hsa047132.38033576
9Glutamatergic synapse_Homo sapiens_hsa047242.34479912
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24195559
11Collecting duct acid secretion_Homo sapiens_hsa049662.22176051
12GABAergic synapse_Homo sapiens_hsa047272.20451058
13Amphetamine addiction_Homo sapiens_hsa050312.15849332
14Insulin secretion_Homo sapiens_hsa049112.05868293
15Salivary secretion_Homo sapiens_hsa049702.02006668
16Dopaminergic synapse_Homo sapiens_hsa047281.94057060
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77929330
18Cholinergic synapse_Homo sapiens_hsa047251.71717947
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65547009
20Serotonergic synapse_Homo sapiens_hsa047261.64228797
21Gastric acid secretion_Homo sapiens_hsa049711.60532800
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57343689
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57232958
24Oxytocin signaling pathway_Homo sapiens_hsa049211.56295316
25Renin secretion_Homo sapiens_hsa049241.56234219
26Long-term depression_Homo sapiens_hsa047301.52298235
27Calcium signaling pathway_Homo sapiens_hsa040201.52075165
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.43353463
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39741137
30Cardiac muscle contraction_Homo sapiens_hsa042601.38210182
31Cocaine addiction_Homo sapiens_hsa050301.31694546
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28931996
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28308208
34GnRH signaling pathway_Homo sapiens_hsa049121.24892899
35Axon guidance_Homo sapiens_hsa043601.24304254
36Vibrio cholerae infection_Homo sapiens_hsa051101.22038513
37Glioma_Homo sapiens_hsa052141.16094569
38Gap junction_Homo sapiens_hsa045401.14819268
39cAMP signaling pathway_Homo sapiens_hsa040241.10564218
40Melanogenesis_Homo sapiens_hsa049161.10427011
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08563607
42Oxidative phosphorylation_Homo sapiens_hsa001901.07942146
43Type II diabetes mellitus_Homo sapiens_hsa049301.07785344
44Estrogen signaling pathway_Homo sapiens_hsa049151.06736787
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03813887
46ErbB signaling pathway_Homo sapiens_hsa040121.03482985
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03473166
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99029658
49Dorso-ventral axis formation_Homo sapiens_hsa043200.93490547
50Phototransduction_Homo sapiens_hsa047440.91451253
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.91209783
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91104735
53Alzheimers disease_Homo sapiens_hsa050100.89562581
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83157986
55Pancreatic secretion_Homo sapiens_hsa049720.78778552
56Dilated cardiomyopathy_Homo sapiens_hsa054140.78697767
57MAPK signaling pathway_Homo sapiens_hsa040100.77685460
58Parkinsons disease_Homo sapiens_hsa050120.76669014
59Rheumatoid arthritis_Homo sapiens_hsa053230.73287698
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72897612
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71951625
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.69370280
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68472825
64Thyroid hormone synthesis_Homo sapiens_hsa049180.67458157
65Wnt signaling pathway_Homo sapiens_hsa043100.67419350
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.66073472
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65904738
68Oocyte meiosis_Homo sapiens_hsa041140.64733058
69Ras signaling pathway_Homo sapiens_hsa040140.62703607
70Choline metabolism in cancer_Homo sapiens_hsa052310.61345947
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58985089
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58608479
73Melanoma_Homo sapiens_hsa052180.58382420
74VEGF signaling pathway_Homo sapiens_hsa043700.57046763
75Vitamin B6 metabolism_Homo sapiens_hsa007500.56686614
76Rap1 signaling pathway_Homo sapiens_hsa040150.51749918
77Huntingtons disease_Homo sapiens_hsa050160.51632340
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51271133
79Bile secretion_Homo sapiens_hsa049760.50686500
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49977870
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48901576
82Phagosome_Homo sapiens_hsa041450.48796531
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48597899
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48199772
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47893489
86Circadian rhythm_Homo sapiens_hsa047100.47540776
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46721070
88African trypanosomiasis_Homo sapiens_hsa051430.46606845
89Insulin signaling pathway_Homo sapiens_hsa049100.46545771
90Endometrial cancer_Homo sapiens_hsa052130.46512690
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46153890
92Endocytosis_Homo sapiens_hsa041440.44423629
93Glucagon signaling pathway_Homo sapiens_hsa049220.42932517
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.42797448
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42707971
96Prolactin signaling pathway_Homo sapiens_hsa049170.42473317
97Lysosome_Homo sapiens_hsa041420.41802027
98Chemokine signaling pathway_Homo sapiens_hsa040620.40976750
99Hedgehog signaling pathway_Homo sapiens_hsa043400.40106298
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39912025
101Alcoholism_Homo sapiens_hsa050340.38032509
102Inositol phosphate metabolism_Homo sapiens_hsa005620.37916437
103Ovarian steroidogenesis_Homo sapiens_hsa049130.36359129
104Mineral absorption_Homo sapiens_hsa049780.34385944
105Renal cell carcinoma_Homo sapiens_hsa052110.34257290
106Renin-angiotensin system_Homo sapiens_hsa046140.34095308
107Prion diseases_Homo sapiens_hsa050200.32667712
108Non-small cell lung cancer_Homo sapiens_hsa052230.32605144
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32203114
110Salmonella infection_Homo sapiens_hsa051320.31966980
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31959868
112mTOR signaling pathway_Homo sapiens_hsa041500.31892975
113Tuberculosis_Homo sapiens_hsa051520.26919800
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19139557
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16065319
116Arginine biosynthesis_Homo sapiens_hsa002200.14981497

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