GFRA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)9.83740913
2positive regulation of meiosis (GO:0045836)9.16048408
3positive regulation of meiotic cell cycle (GO:0051446)8.54070043
4piRNA metabolic process (GO:0034587)7.86093226
5sphingosine metabolic process (GO:0006670)7.75519498
6positive regulation of male gonad development (GO:2000020)7.64455619
7surfactant homeostasis (GO:0043129)7.44001586
8diol metabolic process (GO:0034311)7.31827710
9regulation of glucocorticoid secretion (GO:2000849)7.08684143
10DNA methylation involved in gamete generation (GO:0043046)6.60716357
11negative regulation of meiosis (GO:0045835)6.39183540
12sphingoid metabolic process (GO:0046519)6.30288542
13COPI coating of Golgi vesicle (GO:0048205)6.28752279
14Golgi transport vesicle coating (GO:0048200)6.28752279
15chemical homeostasis within a tissue (GO:0048875)6.26288409
16germ cell migration (GO:0008354)6.23824729
17regulation of male gonad development (GO:2000018)5.96472582
18regulation of corticosteroid hormone secretion (GO:2000846)5.91080526
19oocyte development (GO:0048599)5.72798734
20chemosensory behavior (GO:0007635)5.71688642
21positive regulation of steroid hormone secretion (GO:2000833)5.64702537
22paraxial mesoderm development (GO:0048339)5.62841878
23urinary tract smooth muscle contraction (GO:0014848)5.01160602
24regulation of meiosis (GO:0040020)5.00902870
25meiotic chromosome segregation (GO:0045132)4.95752975
26male sex determination (GO:0030238)4.95318021
27sex differentiation (GO:0007548)4.74992511
28detection of temperature stimulus involved in sensory perception (GO:0050961)4.67882332
29detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.67882332
30positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.54789005
31peristalsis (GO:0030432)4.53421741
32negative regulation of calcium ion transport into cytosol (GO:0010523)4.50897207
33regulation of glucocorticoid metabolic process (GO:0031943)4.45946187
34regulation of activin receptor signaling pathway (GO:0032925)4.44114655
35sulfate transport (GO:0008272)4.37850106
36detection of temperature stimulus (GO:0016048)4.36199046
37peripheral nervous system neuron development (GO:0048935)4.35544469
38insulin secretion (GO:0030073)4.30334891
39regulation of meiotic cell cycle (GO:0051445)4.30119614
40COPII vesicle coating (GO:0048208)4.29506254
41cranial nerve development (GO:0021545)4.29368363
42negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.29000887
43response to ATP (GO:0033198)4.24938836
44microtubule severing (GO:0051013)4.24884442
45regulation of cell maturation (GO:1903429)4.21923989
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.20516278
47positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.20002926
48protein-chromophore linkage (GO:0018298)4.14981950
49regulation of steroid hormone secretion (GO:2000831)4.11855022
50notochord development (GO:0030903)4.06279329
51centriole replication (GO:0007099)4.00823983
52negative regulation of meiotic cell cycle (GO:0051447)3.99445249
53gonadal mesoderm development (GO:0007506)3.98602935
54neuron fate specification (GO:0048665)3.90603238
55neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.89660335
56sulfate transmembrane transport (GO:1902358)3.85582373
57protein retention in ER lumen (GO:0006621)3.85415464
58oogenesis (GO:0048477)3.83657674
59peptide hormone processing (GO:0016486)3.80546555
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.78813641
61Sertoli cell development (GO:0060009)3.78291131
62GMP metabolic process (GO:0046037)3.78114316
63positive regulation of insulin secretion (GO:0032024)3.78094982
64negative regulation of cell cycle G2/M phase transition (GO:1902750)3.76641142
65nodal signaling pathway (GO:0038092)3.74177385
66phasic smooth muscle contraction (GO:0014821)3.73450583
67mitotic sister chromatid cohesion (GO:0007064)3.72620131
68ER overload response (GO:0006983)3.71446206
69mitotic chromosome condensation (GO:0007076)3.70746170
70regulation of protein glycosylation (GO:0060049)3.70487949
71synapsis (GO:0007129)3.69637208
72bundle of His cell to Purkinje myocyte communication (GO:0086069)3.67933905
73endocrine pancreas development (GO:0031018)3.62209449
74glandular epithelial cell differentiation (GO:0002067)3.59571457
75embryonic foregut morphogenesis (GO:0048617)3.59275809
76negative regulation of digestive system process (GO:0060457)3.58683638
77female gamete generation (GO:0007292)3.55807320
78positive regulation of hair cycle (GO:0042635)3.54636882
79positive regulation of hair follicle development (GO:0051798)3.54636882
80mitotic metaphase plate congression (GO:0007080)3.54345279
81regulation of sister chromatid cohesion (GO:0007063)3.53504069
82negative regulation of dendrite morphogenesis (GO:0050774)3.47379764
83negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.46326090
84positive regulation of peptide secretion (GO:0002793)3.45585244
85cullin deneddylation (GO:0010388)3.41864715
86response to pain (GO:0048265)3.41589856
87positive regulation of peptide hormone secretion (GO:0090277)3.37225110
88regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.36358351
89GDP-mannose metabolic process (GO:0019673)3.34338883
90positive regulation of potassium ion transmembrane transport (GO:1901381)3.34206982
91neuronal action potential (GO:0019228)3.31308994
92male meiosis I (GO:0007141)3.30114346
93response to dietary excess (GO:0002021)3.29865895
94chromosome organization involved in meiosis (GO:0070192)3.26760352
95positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.26432278
96sister chromatid cohesion (GO:0007062)3.25734393
97protein maturation by protein folding (GO:0022417)3.23398660
98peptide hormone secretion (GO:0030072)3.21795598
99regulation of transforming growth factor beta2 production (GO:0032909)3.21151826
100gene silencing by RNA (GO:0031047)3.20858751
101nerve development (GO:0021675)3.20499244
102positive regulation of hormone secretion (GO:0046887)3.19794476
103lipopolysaccharide biosynthetic process (GO:0009103)3.16148958
104protein deneddylation (GO:0000338)3.09959214
105vesicle coating (GO:0006901)3.09678596
106peptide secretion (GO:0002790)3.09589847
107establishment of apical/basal cell polarity (GO:0035089)3.08951905
108reciprocal DNA recombination (GO:0035825)3.08796781
109reciprocal meiotic recombination (GO:0007131)3.08796781
110positive regulation of catecholamine secretion (GO:0033605)3.05472733
111DNA alkylation (GO:0006305)3.04392987
112DNA methylation (GO:0006306)3.04392987
113signal peptide processing (GO:0006465)3.04028923
114positive regulation of uterine smooth muscle contraction (GO:0070474)3.03815230
115DNA damage induced protein phosphorylation (GO:0006975)2.97666324
116retinal ganglion cell axon guidance (GO:0031290)2.97249326
117pharyngeal system development (GO:0060037)2.95727059
118ER to Golgi vesicle-mediated transport (GO:0006888)2.94918085
119meiotic cell cycle (GO:0051321)2.93881379
120regulation of uterine smooth muscle contraction (GO:0070472)2.92598030
121regulation of insulin secretion (GO:0050796)2.92211462
122regulation of cardioblast proliferation (GO:0003264)2.91576769
123regulation of secondary heart field cardioblast proliferation (GO:0003266)2.91576769
124vitamin transmembrane transport (GO:0035461)2.91551893
125centriole assembly (GO:0098534)2.90567735
126toxin metabolic process (GO:0009404)2.89273837
127ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.88368648
128positive regulation of reproductive process (GO:2000243)2.88298757
129negative regulation of norepinephrine secretion (GO:0010700)2.87760015
130sex determination (GO:0007530)2.87231292
131meiotic cell cycle process (GO:1903046)2.85740549
132spindle assembly involved in mitosis (GO:0090307)2.85186273
133metaphase plate congression (GO:0051310)2.85149395
134auditory receptor cell differentiation (GO:0042491)2.83264644
135positive regulation of vesicle fusion (GO:0031340)2.83104319
136L-alpha-amino acid transmembrane transport (GO:1902475)2.82594399
137regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.82285549
138cellular zinc ion homeostasis (GO:0006882)2.81445780
139meiosis I (GO:0007127)2.77508928
140hormone secretion (GO:0046879)2.76366228
141regulation of peptide secretion (GO:0002791)2.76164664
142regulation of peptide hormone secretion (GO:0090276)2.74547787
143regulation of posttranscriptional gene silencing (GO:0060147)2.73731091
144regulation of gene silencing by miRNA (GO:0060964)2.73731091
145regulation of gene silencing by RNA (GO:0060966)2.73731091
146regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.73553238
147proline biosynthetic process (GO:0006561)2.73073066
148neuroblast proliferation (GO:0007405)2.72210750
149cellular response to nicotine (GO:0071316)2.69982578
150regulation of nuclear cell cycle DNA replication (GO:0033262)2.69645870
151regulation of hair follicle development (GO:0051797)2.69493581
152regulation of type B pancreatic cell apoptotic process (GO:2000674)2.69422471
153intra-Golgi vesicle-mediated transport (GO:0006891)2.69024450
154innervation (GO:0060384)2.68978477
155negative regulation of JUN kinase activity (GO:0043508)2.67047479
156membrane budding (GO:0006900)2.66647622
157somite rostral/caudal axis specification (GO:0032525)2.65901657
158sequestering of metal ion (GO:0051238)2.65426844
159nitric oxide mediated signal transduction (GO:0007263)2.65030835
160regulation of hormone secretion (GO:0046883)2.64981750
161trivalent inorganic anion homeostasis (GO:0072506)2.64868109
162phosphate ion homeostasis (GO:0055062)2.64868109
163epithelial cell fate commitment (GO:0072148)2.64073279
164chromosome condensation (GO:0030261)2.61038435
165endocardial cushion morphogenesis (GO:0003203)2.60836107
166cornea development in camera-type eye (GO:0061303)2.60517035
167positive regulation of nuclear division (GO:0051785)2.59288343
168negative regulation of bone resorption (GO:0045779)2.58988661
169synaptonemal complex assembly (GO:0007130)2.58963184
170germ cell development (GO:0007281)2.58943593
171negative regulation of neurological system process (GO:0031645)2.58767618
172melanosome transport (GO:0032402)2.58527681
173positive regulation of amine transport (GO:0051954)2.58383387
174aspartate family amino acid catabolic process (GO:0009068)2.58003121
175neuropeptide signaling pathway (GO:0007218)2.57627761
176cell migration in hindbrain (GO:0021535)2.57516221
177meiotic nuclear division (GO:0007126)2.57473566
178hormone transport (GO:0009914)2.56051497
179interkinetic nuclear migration (GO:0022027)2.55783911
180positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.55290440
181phenol-containing compound catabolic process (GO:0019336)2.55056477
182negative regulation of organelle assembly (GO:1902116)2.54542030
183negative regulation of microtubule depolymerization (GO:0007026)2.54215087
184glycine transport (GO:0015816)2.54177595
185establishment of monopolar cell polarity (GO:0061162)2.53309839
186establishment or maintenance of monopolar cell polarity (GO:0061339)2.53309839
187male meiosis (GO:0007140)2.53219523
188DNA replication initiation (GO:0006270)2.52491382
189lysine catabolic process (GO:0006554)2.51659803
190lysine metabolic process (GO:0006553)2.51659803
191mitotic sister chromatid segregation (GO:0000070)2.51242107
192exocrine pancreas development (GO:0031017)2.46730335
193epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.46139139
194lipopolysaccharide metabolic process (GO:0008653)2.45694942
195negative regulation of glycoprotein biosynthetic process (GO:0010561)2.45475085
196regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.44440469
197single strand break repair (GO:0000012)2.43182692
198regulation of meiosis I (GO:0060631)14.6355221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse6.01904376
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.90742071
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.68005060
4HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse4.34346352
5PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.30209513
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.22626526
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.17494375
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.01529075
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.01529075
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.01529075
11EZH2_22144423_ChIP-Seq_EOC_Human3.72480337
12E2F7_22180533_ChIP-Seq_HELA_Human3.60845539
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.56448272
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.22483203
15IGF1R_20145208_ChIP-Seq_DFB_Human3.16059469
16NR3C1_23031785_ChIP-Seq_PC12_Mouse3.01625946
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.72891059
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60616375
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.45538751
20VDR_22108803_ChIP-Seq_LS180_Human2.41063548
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33703146
22AR_21572438_ChIP-Seq_LNCaP_Human2.30326257
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29858364
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25089537
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23345030
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20478203
27ESR1_15608294_ChIP-ChIP_MCF-7_Human2.16416385
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12723830
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11302174
30TRIM28_21343339_ChIP-Seq_HEK293_Human2.01244139
31OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.01195981
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98443371
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98331629
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89531186
35RNF2_27304074_Chip-Seq_NSC_Mouse1.88554410
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.85821142
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82101476
38CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.78246370
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.76292595
40SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.75748788
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74414878
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.74281863
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.70115904
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68921623
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64228708
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63758648
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.60880035
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.57630070
49HOXB7_26014856_ChIP-Seq_BT474_Human1.56838738
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.53178501
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49830374
52REST_19997604_ChIP-ChIP_NEURONS_Mouse1.49659106
53ZNF274_21170338_ChIP-Seq_K562_Hela1.45514529
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45325768
55LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42987134
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40736893
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37880667
58CLOCK_20551151_ChIP-Seq_293T_Human1.37119760
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36977817
60STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.36626403
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.34478126
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33167870
63AR_21909140_ChIP-Seq_LNCAP_Human1.29862744
64REST_21632747_ChIP-Seq_MESCs_Mouse1.27593842
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.27535737
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.26852297
67ZNF263_19887448_ChIP-Seq_K562_Human1.25615689
68CTCF_27219007_Chip-Seq_Bcells_Human1.25498332
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.25497121
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24778325
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24497292
72STAT3_18555785_ChIP-Seq_MESCs_Mouse1.22095147
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.18128499
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17585126
75SOX17_20123909_ChIP-Seq_XEN_Mouse1.14456338
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13684392
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.12995949
78TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12147216
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11834728
80MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10182934
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.09684153
82XRN2_22483619_ChIP-Seq_HELA_Human1.09675779
83TET1_21490601_ChIP-Seq_MESCs_Mouse1.09641540
84ELK1_19687146_ChIP-ChIP_HELA_Human1.09353756
85* SOX2_20726797_ChIP-Seq_SW620_Human1.09137249
86GABP_19822575_ChIP-Seq_HepG2_Human1.06489778
87GATA4_25053715_ChIP-Seq_YYC3_Human1.03173813
88* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03064077
89FOXH1_21741376_ChIP-Seq_ESCs_Human1.02979063
90GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01379178
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00757734
92* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00659030
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00534133
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00486280
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.00208455
96GATA1_22025678_ChIP-Seq_K562_Human1.00205493
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99941292
98ISL1_27105846_Chip-Seq_CPCs_Mouse0.99654453
99NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95226614
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95224620
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95224620
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91737292
103THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91668564
104E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91421857
105JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91330159
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90920495
107AHR_22903824_ChIP-Seq_MCF-7_Human0.90704445
108WDR5_24793694_ChIP-Seq_LNCAP_Human0.90677615
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90370692
110EZH2_27304074_Chip-Seq_ESCs_Mouse0.90199727
111OCT4_19829295_ChIP-Seq_ESCs_Human0.88582868
112* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88527513
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88260455
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87929521
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86996500
116TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86959831
117RNF2_27304074_Chip-Seq_ESCs_Mouse0.86827748
118ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86606310
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86513089
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85082536
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85057884
122* ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84242278
123SRF_21415370_ChIP-Seq_HL-1_Mouse0.83815817
124RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83637471
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83625396
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83569914
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.83013160
128NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82497932
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82016862
130PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81151967
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.81003788
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.80424469
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80214239
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79767587
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79626784
136* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.79531896
137EP300_21415370_ChIP-Seq_HL-1_Mouse0.79159226
138* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79034715
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.78813216
140AR_19668381_ChIP-Seq_PC3_Human0.78671557
141PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.78590027
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.78499769
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78124174
144* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.77771285
145SALL1_21062744_ChIP-ChIP_HESCs_Human0.77402888
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77070956
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.77031918
148ESR1_20079471_ChIP-ChIP_T-47D_Human0.76974098
149* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.76726785
150TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76563577
151TP53_22573176_ChIP-Seq_HFKS_Human0.76297395
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75880435
153STAT3_23295773_ChIP-Seq_U87_Human0.75527849
154ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75407452
155AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74884440
156FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74743481
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.74307212
158SMAD4_21741376_ChIP-Seq_HESCs_Human0.73975701
159DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.73929314
160GF1B_26923725_Chip-Seq_HPCs_Mouse0.73744898
161SUZ12_27294783_Chip-Seq_ESCs_Mouse0.73490240
162CIITA_25753668_ChIP-Seq_RAJI_Human0.73487180
163EGR1_19032775_ChIP-ChIP_M12_Human0.73357081
164TOP2B_26459242_ChIP-Seq_MCF-7_Human0.73347898
165NCOR_22424771_ChIP-Seq_293T_Human0.72565028
166SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72363980
167SMC4_20622854_ChIP-Seq_HELA_Human0.72050813
168GATA3_24758297_ChIP-Seq_MCF-7_Human0.71994564
169EOMES_21245162_ChIP-Seq_HESCs_Human0.71852991
170JARID2_20075857_ChIP-Seq_MESCs_Mouse0.71573454
171TCF4_23295773_ChIP-Seq_U87_Human0.71219099
172RUNX1_27514584_Chip-Seq_MCF-7_Human0.71045289
173* FOXH1_21741376_ChIP-Seq_EPCs_Human0.70911486
174ESET_19884257_ChIP-Seq_ESCs_Mouse0.70692845
175STAT1_20625510_ChIP-Seq_HELA_Human0.70631933
176CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70497463
177TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.69273945
178KLF5_25053715_ChIP-Seq_YYC3_Human0.69007341
179OCT4_20526341_ChIP-Seq_ESCs_Human0.68576869
180EZH2_27294783_Chip-Seq_ESCs_Mouse0.68341879
181SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.67994744
182ARNT_22903824_ChIP-Seq_MCF-7_Human0.67627736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity7.99497634
2MP0002735_abnormal_chemical_nociception5.32608023
3MP0003136_yellow_coat_color4.73235296
4MP0004858_abnormal_nervous_system4.67300849
5MP0005171_absent_coat_pigmentation4.54847919
6MP0002163_abnormal_gland_morphology4.14348095
7MP0003890_abnormal_embryonic-extraembry3.88903325
8MP0004270_analgesia3.76035421
9MP0005379_endocrine/exocrine_gland_phen3.75045025
10MP0010386_abnormal_urinary_bladder3.39270169
11MP0004782_abnormal_surfactant_physiolog3.30025631
12MP0006276_abnormal_autonomic_nervous3.12190689
13MP0001968_abnormal_touch/_nociception2.99162937
14MP0002837_dystrophic_cardiac_calcinosis2.92155479
15MP0003646_muscle_fatigue2.90417869
16MP0000013_abnormal_adipose_tissue2.86365393
17MP0002734_abnormal_mechanical_nocicepti2.82403725
18* MP0002751_abnormal_autonomic_nervous2.58382585
19MP0002733_abnormal_thermal_nociception2.58198179
20MP0004147_increased_porphyrin_level2.57862535
21MP0002877_abnormal_melanocyte_morpholog2.55266566
22MP0002909_abnormal_adrenal_gland2.42322914
23MP0005646_abnormal_pituitary_gland2.39514911
24MP0001756_abnormal_urination2.32729218
25MP0000383_abnormal_hair_follicle2.24144264
26MP0003195_calcinosis2.16614843
27MP0002638_abnormal_pupillary_reflex2.14552329
28MP0005645_abnormal_hypothalamus_physiol2.12902636
29MP0000566_synostosis2.12893607
30MP0008995_early_reproductive_senescence2.11454770
31MP0005076_abnormal_cell_differentiation2.03805091
32MP0001970_abnormal_pain_threshold1.99305855
33MP0003122_maternal_imprinting1.99076836
34MP0008004_abnormal_stomach_pH1.92343623
35MP0000427_abnormal_hair_cycle1.88019704
36MP0005670_abnormal_white_adipose1.83605619
37MP0008877_abnormal_DNA_methylation1.80183570
38MP0002210_abnormal_sex_determination1.77637420
39MP0001944_abnormal_pancreas_morphology1.73761654
40MP0000003_abnormal_adipose_tissue1.73432189
41MP0001958_emphysema1.65851596
42MP0002693_abnormal_pancreas_physiology1.65340306
43MP0009780_abnormal_chondrocyte_physiolo1.65121409
44MP0010678_abnormal_skin_adnexa1.63457088
45MP0005330_cardiomyopathy1.62981581
46MP0002160_abnormal_reproductive_system1.60703684
47MP0003183_abnormal_peptide_metabolism1.52880061
48MP0009379_abnormal_foot_pigmentation1.50363794
49MP0000678_abnormal_parathyroid_gland1.47568342
50MP0004381_abnormal_hair_follicle1.45285409
51MP0004084_abnormal_cardiac_muscle1.44958676
52MP0002938_white_spotting1.43802960
53MP0000569_abnormal_digit_pigmentation1.43267132
54MP0001929_abnormal_gametogenesis1.40996267
55MP0005174_abnormal_tail_pigmentation1.38851849
56MP0003718_maternal_effect1.38171128
57MP0003123_paternal_imprinting1.35759481
58MP0002098_abnormal_vibrissa_morphology1.34274117
59MP0004215_abnormal_myocardial_fiber1.32774741
60MP0005220_abnormal_exocrine_pancreas1.32403003
61MP0010352_gastrointestinal_tract_polyps1.30911733
62MP0005075_abnormal_melanosome_morpholog1.30771574
63MP0001145_abnormal_male_reproductive1.29679757
64MP0003137_abnormal_impulse_conducting1.27160902
65* MP0002184_abnormal_innervation1.24114239
66MP0005408_hypopigmentation1.22626127
67MP0008260_abnormal_autophagy1.20146005
68MP0000653_abnormal_sex_gland1.19198205
69MP0006072_abnormal_retinal_apoptosis1.16970993
70MP0000538_abnormal_urinary_bladder1.16512154
71MP0004043_abnormal_pH_regulation1.15977853
72MP0003806_abnormal_nucleotide_metabolis1.15536782
73MP0002653_abnormal_ependyma_morphology1.15328180
74MP0004957_abnormal_blastocyst_morpholog1.14195542
75MP0005409_darkened_coat_color1.12062206
76MP0004272_abnormal_basement_membrane1.08227196
77MP0001984_abnormal_olfaction1.07023455
78MP0003693_abnormal_embryo_hatching1.07019292
79MP0010307_abnormal_tumor_latency1.05622172
80MP0008775_abnormal_heart_ventricle1.05073704
81MP0001299_abnormal_eye_distance/1.04206398
82MP0010030_abnormal_orbit_morphology1.02437457
83MP0003111_abnormal_nucleus_morphology1.01931479
84MP0005448_abnormal_energy_balance0.98568200
85MP0003698_abnormal_male_reproductive0.97199721
86MP0002078_abnormal_glucose_homeostasis0.96800859
87MP0005666_abnormal_adipose_tissue0.95522750
88MP0005167_abnormal_blood-brain_barrier0.94979840
89MP0001730_embryonic_growth_arrest0.93748142
90MP0001270_distended_abdomen0.89524197
91MP0005377_hearing/vestibular/ear_phenot0.86460191
92MP0003878_abnormal_ear_physiology0.86460191
93MP0000647_abnormal_sebaceous_gland0.86000254
94MP0003937_abnormal_limbs/digits/tail_de0.85379140
95MP0001485_abnormal_pinna_reflex0.85256463
96MP0008932_abnormal_embryonic_tissue0.84543840
97MP0008057_abnormal_DNA_replication0.83426652
98MP0002796_impaired_skin_barrier0.82951518
99MP0005395_other_phenotype0.82692922
100MP0003705_abnormal_hypodermis_morpholog0.82112780
101MP0003953_abnormal_hormone_level0.82072656
102MP0001348_abnormal_lacrimal_gland0.82025596
103MP0003283_abnormal_digestive_organ0.80431172
104MP0008872_abnormal_physiological_respon0.79552727
105MP0002896_abnormal_bone_mineralization0.79378713
106MP0009250_abnormal_appendicular_skeleto0.79289200
107MP0001324_abnormal_eye_pigmentation0.78353124
108MP0002067_abnormal_sensory_capabilities0.78223630
109MP0005386_behavior/neurological_phenoty0.76065834
110MP0004924_abnormal_behavior0.76065834
111MP0004233_abnormal_muscle_weight0.75967567
112MP0001529_abnormal_vocalization0.75911728
113MP0000749_muscle_degeneration0.74446930
114MP0002095_abnormal_skin_pigmentation0.74175825
115MP0005257_abnormal_intraocular_pressure0.72876688
116MP0002269_muscular_atrophy0.72382636
117MP0000462_abnormal_digestive_system0.71597075
118MP0003567_abnormal_fetal_cardiomyocyte0.71383208
119MP0004036_abnormal_muscle_relaxation0.71075507
120MP0004145_abnormal_muscle_electrophysio0.70674183
121MP0000026_abnormal_inner_ear0.70593279
122MP0004264_abnormal_extraembryonic_tissu0.70308213
123MP0003943_abnormal_hepatobiliary_system0.70003060
124MP0003077_abnormal_cell_cycle0.69151637
125MP0002075_abnormal_coat/hair_pigmentati0.68090075
126MP0000377_abnormal_hair_follicle0.68056014
127MP0003045_fibrosis0.67461548
128MP0002272_abnormal_nervous_system0.67416497
129MP0005367_renal/urinary_system_phenotyp0.67292504
130MP0000516_abnormal_urinary_system0.67292504
131MP0005085_abnormal_gallbladder_physiolo0.67152123
132MP0000613_abnormal_salivary_gland0.66532076
133MP0003121_genomic_imprinting0.66393985
134MP0001119_abnormal_female_reproductive0.65873171
135* MP0004811_abnormal_neuron_physiology0.64575994
136MP0001697_abnormal_embryo_size0.64233869
137MP0003119_abnormal_digestive_system0.63105667
138MP0003879_abnormal_hair_cell0.63009905
139MP0002127_abnormal_cardiovascular_syste0.62884586
140MP0008789_abnormal_olfactory_epithelium0.62867277
141MP0003935_abnormal_craniofacial_develop0.62357621
142MP0005365_abnormal_bile_salt0.62105557
143MP0000534_abnormal_ureter_morphology0.61553203
144MP0002084_abnormal_developmental_patter0.61525255
145MP0002572_abnormal_emotion/affect_behav0.60642656
146MP0004185_abnormal_adipocyte_glucose0.60221269
147MP0002822_catalepsy0.59710265
148MP0002970_abnormal_white_adipose0.58847690
149MP0001502_abnormal_circadian_rhythm0.58636739
150MP0002085_abnormal_embryonic_tissue0.58123335
151MP0008058_abnormal_DNA_repair0.57795985
152MP0005334_abnormal_fat_pad0.57540756
153MP0004085_abnormal_heartbeat0.57144558
154MP0003936_abnormal_reproductive_system0.56836241
155MP0001440_abnormal_grooming_behavior0.56729168
156MP0005389_reproductive_system_phenotype0.56689431
157MP0002161_abnormal_fertility/fecundity0.56499413
158MP0002089_abnormal_postnatal_growth/wei0.56301112
159MP0005083_abnormal_biliary_tract0.56093095
160MP0002736_abnormal_nociception_after0.55860059
161MP0002168_other_aberrant_phenotype0.55469320
162MP0000372_irregular_coat_pigmentation0.54838421
163MP0001542_abnormal_bone_strength0.54773691
164MP0003950_abnormal_plasma_membrane0.53176952
165MP0001765_abnormal_ion_homeostasis0.52971545
166MP0005636_abnormal_mineral_homeostasis0.52723056
167MP0003959_abnormal_lean_body0.50080749
168MP0000955_abnormal_spinal_cord0.49723421
169MP0009643_abnormal_urine_homeostasis0.49701071
170* MP0002882_abnormal_neuron_morphology0.48315045
171MP0002069_abnormal_eating/drinking_beha0.48226502
172MP0005535_abnormal_body_temperature0.46837371
173MP0002876_abnormal_thyroid_physiology0.46550512
174MP0009745_abnormal_behavioral_response0.45675010
175MP0004484_altered_response_of0.45535134
176MP0005375_adipose_tissue_phenotype0.44637828
177MP0000230_abnormal_systemic_arterial0.44521395
178MP0009697_abnormal_copulation0.43900915
179MP0000639_abnormal_adrenal_gland0.43518884
180MP0003942_abnormal_urinary_system0.43469560

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)6.64799162
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.87152760
3Abnormality of calcium-phosphate metabolism (HP:0100530)5.65829848
4Hyperinsulinemic hypoglycemia (HP:0000825)5.42025587
5Amelogenesis imperfecta (HP:0000705)5.30263515
6Dysautonomia (HP:0002459)5.22847856
7Hyperglycemia (HP:0003074)4.90175156
8Hypoglycemic seizures (HP:0002173)4.76206685
9Hypoglycemic coma (HP:0001325)4.58125991
10Pheochromocytoma (HP:0002666)4.34260387
11Hypothermia (HP:0002045)4.22881429
12Symptomatic seizures (HP:0011145)4.21695936
13Synostosis of carpal bones (HP:0005048)4.21363609
14Neuroendocrine neoplasm (HP:0100634)3.95526450
15Orthostatic hypotension (HP:0001278)3.91512746
16Late onset (HP:0003584)3.81120542
17Birth length less than 3rd percentile (HP:0003561)3.76196162
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.75958564
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.75958564
20Abnormal autonomic nervous system physiology (HP:0012332)3.74072589
21Abnormality of endocrine pancreas physiology (HP:0012093)3.60545351
22Abnormality of the pancreatic islet cells (HP:0006476)3.60545351
23Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)3.59030909
24Acanthocytosis (HP:0001927)3.54065813
25Right ventricular cardiomyopathy (HP:0011663)3.32696774
26Hypercortisolism (HP:0001578)3.30399224
27Hyperparathyroidism (HP:0000843)3.29399819
28Carpal bone hypoplasia (HP:0001498)3.28113149
29Natal tooth (HP:0000695)3.26787319
30Ketoacidosis (HP:0001993)3.26396393
31Growth hormone excess (HP:0000845)3.24729777
32Insulin-resistant diabetes mellitus (HP:0000831)3.17011456
33Vertebral arch anomaly (HP:0008438)3.15856692
34Tubulointerstitial fibrosis (HP:0005576)3.12711690
35Facial cleft (HP:0002006)3.05286047
36Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.05245132
37Abnormality of dental color (HP:0011073)3.04760906
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.99558517
39Carpal synostosis (HP:0009702)2.94757203
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.91707605
41Agitation (HP:0000713)2.91068540
42Ulnar claw (HP:0001178)2.84592641
43Menstrual irregularities (HP:0000858)2.77090765
44Abnormality of the corticospinal tract (HP:0002492)2.76879792
45Pendular nystagmus (HP:0012043)2.76342526
46Abnormal pancreas size (HP:0012094)2.74057631
47Pancreatic islet-cell hyperplasia (HP:0004510)2.71159830
48Upper limb muscle weakness (HP:0003484)2.70313997
49Abnormality of pain sensation (HP:0010832)2.68040603
50Impaired pain sensation (HP:0007328)2.68040603
51Gout (HP:0001997)2.65913760
52Prominent metopic ridge (HP:0005487)2.62454262
53Short nail (HP:0001799)2.62071184
54Cortical dysplasia (HP:0002539)2.61864935
55Segmental peripheral demyelination/remyelination (HP:0003481)2.59991102
56Flattened epiphyses (HP:0003071)2.59311506
57Focal motor seizures (HP:0011153)2.57896753
58Severe Myopia (HP:0011003)2.52540199
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.48015462
60Breast hypoplasia (HP:0003187)2.46246592
61Advanced eruption of teeth (HP:0006288)2.46204896
62Abnormality of the vocal cords (HP:0008777)2.45950474
63Short ribs (HP:0000773)2.43467180
64Hypsarrhythmia (HP:0002521)2.43306837
65EEG with generalized epileptiform discharges (HP:0011198)2.42348736
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41180521
67Synostosis involving bones of the hand (HP:0004278)2.40406018
68Proximal tubulopathy (HP:0000114)2.38997922
69Rectal prolapse (HP:0002035)2.37345572
70Abnormality of the metopic suture (HP:0005556)2.36084329
71Abnormality of the alveolar ridges (HP:0006477)2.35653160
72Central scotoma (HP:0000603)2.35251127
73Disproportionate short-trunk short stature (HP:0003521)2.34466605
74Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.33744409
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.33591515
76Hypoplasia of the fovea (HP:0007750)2.33591515
77Restlessness (HP:0000711)2.31979419
78Tubular atrophy (HP:0000092)2.30551800
79Abnormality of macular pigmentation (HP:0008002)2.30025184
80Epileptiform EEG discharges (HP:0011182)2.26044209
81Hypoventilation (HP:0002791)2.23807882
82Abnormality of the fovea (HP:0000493)2.23185498
83Shoulder girdle muscle weakness (HP:0003547)2.20680018
84Delayed epiphyseal ossification (HP:0002663)2.20639900
85Short thorax (HP:0010306)2.20275702
86Abnormality of the hip-girdle musculature (HP:0001445)2.19038358
87Abnormality of the musculature of the pelvis (HP:0001469)2.19038358
88Hypotension (HP:0002615)2.17440441
89Male pseudohermaphroditism (HP:0000037)2.17369674
90Aplasia/Hypoplasia of the sternum (HP:0006714)2.16356491
91Depressed nasal tip (HP:0000437)2.15788967
92Broad distal phalanx of finger (HP:0009836)2.13063258
93Neoplasm of the adrenal gland (HP:0100631)2.12930384
94Progressive neurologic deterioration (HP:0002344)2.11588600
95Generalized aminoaciduria (HP:0002909)2.10742185
96Autoamputation (HP:0001218)2.10346803
97Tubulointerstitial abnormality (HP:0001969)2.09372978
98Flat capital femoral epiphysis (HP:0003370)2.08565154
99Complete atrioventricular canal defect (HP:0001674)2.08540610
100Insulin resistance (HP:0000855)2.08146606
101Aplasia/Hypoplasia involving the musculature (HP:0001460)2.08134956
102Cervical subluxation (HP:0003308)2.07975522
103Diastasis recti (HP:0001540)2.07345139
104Congenital ichthyosiform erythroderma (HP:0007431)2.06616347
105Neoplasm of the thyroid gland (HP:0100031)2.06483640
106Glucose intolerance (HP:0000833)2.05664704
107Abnormality of the epiphyses of the hand (HP:0005924)2.03930930
108Syncope (HP:0001279)2.03208625
109Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.01002323
110Hypokalemia (HP:0002900)2.00828805
111Patellar aplasia (HP:0006443)2.00751839
112Hand muscle atrophy (HP:0009130)2.00259057
113Parakeratosis (HP:0001036)1.99404020
114Pelvic girdle muscle weakness (HP:0003749)1.99100626
115Colon cancer (HP:0003003)1.98778670
116Thyroid carcinoma (HP:0002890)1.97822237
117Impaired vibration sensation in the lower limbs (HP:0002166)1.97471660
118Increased nuchal translucency (HP:0010880)1.96539058
119Tachypnea (HP:0002789)1.95911982
120Irregular vertebral endplates (HP:0003301)1.95605062
121Abnormality of the renal cortex (HP:0011035)1.95563034
122Scotoma (HP:0000575)1.95421292
123Chromsome breakage (HP:0040012)1.94352659
124Metaphyseal cupping (HP:0003021)1.93906429
125Hepatoblastoma (HP:0002884)1.93716094
126Malignant gastrointestinal tract tumors (HP:0006749)1.93697230
127Gastrointestinal carcinoma (HP:0002672)1.93697230
128Adrenal overactivity (HP:0002717)1.93687081
129Urinary urgency (HP:0000012)1.93030827
130Rimmed vacuoles (HP:0003805)1.92217084
131Ectopic kidney (HP:0000086)1.92102538
132Large for gestational age (HP:0001520)1.88662011
133Hypoplasia of the uterus (HP:0000013)1.88570092
134Respiratory distress (HP:0002098)1.88500431
135Impulsivity (HP:0100710)1.88029239
136Submucous cleft hard palate (HP:0000176)1.87719854
137Aplasia/hypoplasia of the uterus (HP:0008684)1.87687951
138Difficulty climbing stairs (HP:0003551)1.87677808
139Aplasia/Hypoplasia of the patella (HP:0006498)1.87479797
140Hyperactive renin-angiotensin system (HP:0000841)1.86852803
141Poor head control (HP:0002421)1.85521824
142Areflexia of lower limbs (HP:0002522)1.84847697
143Abnormality of the dental pulp (HP:0006479)1.84657890
144Ventricular fibrillation (HP:0001663)1.84623211
145Osteomalacia (HP:0002749)1.83643403
146Postaxial foot polydactyly (HP:0001830)1.83097122
147Morphological abnormality of the inner ear (HP:0011390)1.83048562
148Neoplasm of the peripheral nervous system (HP:0100007)1.82684087
149Hypoplastic iliac wings (HP:0002866)1.79420706
150Scapular winging (HP:0003691)1.79402043
151Hyperaldosteronism (HP:0000859)1.78256831
152Genu varum (HP:0002970)1.78233247
153Interstitial pulmonary disease (HP:0006530)1.76918042
154Retinal dysplasia (HP:0007973)1.76403682
155Cutaneous finger syndactyly (HP:0010554)1.74984377
156Bicornuate uterus (HP:0000813)1.73593089
157Proximal amyotrophy (HP:0007126)1.73481029
158Protuberant abdomen (HP:0001538)1.72838237
159Intestinal atresia (HP:0011100)1.72647450
160Muscle fibrillation (HP:0010546)1.72443013
161Bifid tongue (HP:0010297)1.72430799
162Aplasia/Hypoplasia of the macula (HP:0008059)1.71739618
163Cubitus valgus (HP:0002967)1.71166671
164Urinary bladder sphincter dysfunction (HP:0002839)1.70959803
165Pancreatic cysts (HP:0001737)1.70815405
166Small epiphyses (HP:0010585)1.70457433
167Failure to thrive in infancy (HP:0001531)1.70303323
168Decreased circulating renin level (HP:0003351)1.69524883
169Distal sensory impairment (HP:0002936)1.68093934
170Abnormality of the dental root (HP:0006486)1.67993492
171Taurodontia (HP:0000679)1.67993492
172Abnormality of permanent molar morphology (HP:0011071)1.67993492
173Abnormality of the shoulder girdle musculature (HP:0001435)1.67682346
174Bell-shaped thorax (HP:0001591)1.67655298
175Exocrine pancreatic insufficiency (HP:0001738)1.67622667
176Termporal pattern (HP:0011008)1.67484200
177Insidious onset (HP:0003587)1.67484200
178Irregular epiphyses (HP:0010582)1.67268317
179Neonatal death (HP:0003811)1.66484618
180Gonadal dysgenesis (HP:0000133)1.65507926
181Abnormality of monocarboxylic acid metabolism (HP:0010996)1.65091970
182Flared iliac wings (HP:0002869)1.64918069
183Duplication of thumb phalanx (HP:0009942)1.64568673
184Myokymia (HP:0002411)1.63450914
185Abnormality of the parathyroid morphology (HP:0011766)1.62647421
186Retinal atrophy (HP:0001105)1.62480654
187Neuroblastic tumors (HP:0004376)1.62467761
188Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.62467761
189Neuroblastoma (HP:0003006)1.62467761
190Primitive neuroectodermal tumor (HP:0030065)1.62467761
191Papillary thyroid carcinoma (HP:0002895)1.62350182
192Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.60263822
193Thoracolumbar scoliosis (HP:0002944)1.60237110
194Ulnar deviation of the wrist (HP:0003049)1.60107180
195Type II lissencephaly (HP:0007260)1.59759310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS18.85991404
2MAPK156.38105581
3STK38L6.15585079
4WNK34.67027900
5PNCK4.15194810
6CCNB13.10577355
7INSRR2.98179441
8PRKD32.88772602
9PIK3CG2.69897044
10MAPKAPK32.64606946
11NTRK12.48626522
12STK32.31299333
13AKT32.28264048
14MAP3K22.23067572
15EPHA32.15542159
16STK382.07333222
17TTK2.01705717
18NEK22.01088916
19STK161.99668720
20BMPR1B1.94477097
21CDK191.90076001
22CAMKK21.87818458
23UHMK11.71451988
24SIK31.67488146
25PASK1.61657382
26LIMK11.59472106
27WNK41.58167604
28ARAF1.57543709
29BUB11.48453540
30KSR21.46111424
31BRAF1.43780326
32MAP2K21.42018606
33MELK1.35420963
34MINK11.32402530
35BRSK21.30131907
36FRK1.29278059
37SGK4941.28819127
38SGK2231.28819127
39MAP2K11.28367652
40STK241.28265845
41HIPK21.25162643
42SGK21.18990762
43PRKCE1.14189928
44TSSK61.13511243
45STK391.12719570
46FER1.12038162
47TESK11.11720963
48EPHB11.10421309
49MAP3K101.08595855
50DYRK21.08308231
51NTRK31.07650511
52WEE11.07490354
53SCYL21.07384891
54ERBB21.02953012
55BCR1.02002256
56DAPK21.01857709
57RET0.97771025
58BRSK10.96695301
59PLK10.96178445
60MET0.94108223
61MATK0.93828909
62PTK20.93658870
63GRK50.91398021
64TESK20.90759035
65CAMK1G0.89026630
66PLK30.85127138
67MAP3K30.83619590
68CASK0.81494778
69MAP3K70.80703070
70AURKA0.76655628
71ADRBK20.75137795
72CDC42BPA0.72987629
73EEF2K0.71612564
74PKN20.71350245
75PAK30.69164711
76CDC70.67824837
77RPS6KA20.65657590
78RPS6KB20.65247300
79TAF10.63775672
80NME10.63334876
81CAMK1D0.62991504
82PBK0.62054125
83MAPK130.61622423
84NLK0.61362035
85DYRK1A0.60320885
86PINK10.58879865
87PIM20.58878372
88PDPK10.57875912
89AKT20.57787330
90BMX0.57048897
91RPS6KA60.56135512
92EIF2AK30.55477275
93FGFR40.55107445
94DYRK1B0.52852898
95PRKAA20.52805897
96PRKG20.51670529
97MAP3K10.51397248
98NEK10.50717551
99ACVR1B0.50082473
100LATS20.49731837
101ERBB30.49221272
102TRIB30.49144715
103CDK120.48219067
104SGK30.47685797
105PRKCI0.47208359
106CSNK1G30.46906110
107MTOR0.46885320
108RPS6KL10.45985709
109RPS6KC10.45985709
110CDK80.45246641
111ADRBK10.44381165
112PDK30.43933907
113PDK40.43933907
114TGFBR10.42944612
115RIPK10.42527392
116PRKD10.42133174
117NEK90.41783967
118CSNK1G10.41485703
119PLK40.41153137
120CDK40.41098940
121FGFR20.40343595
122ICK0.40190677
123CHEK20.39528545
124PRKCH0.38019516
125MAPKAPK20.37523908
126IRAK10.36630632
127MARK30.36547766
128CSNK1A1L0.34016171
129EPHA20.33600719
130WNK10.33407652
131PRKCG0.33406676
132PDGFRB0.32667369
133AURKB0.32263762
134CAMKK10.32037127
135MAP3K110.31859264
136PTK60.31651183
137YES10.30796261
138KSR10.30779719
139CSNK1A10.30431903
140DAPK10.29224333
141ATR0.28200779
142CAMK2D0.28039596
143PDGFRA0.27706974
144MAP3K90.26427973
145ZAK0.26240989
146CHEK10.26174624
147GRK70.25571287
148MUSK0.24744195
149CDK90.24295680
150PRKACA0.24169151
151PAK10.23330551
152CDK70.23216734
153LRRK20.22506609
154NTRK20.21670327
155LMTK20.21462454
156CDK10.21427967
157ATM0.21047472
158CAMK2A0.20686351
159FGFR30.19660770
160DDR20.19574126
161TNK20.19517790
162CDK30.18610110
163OXSR10.18039896
164RPS6KB10.15710600
165TAOK30.14798853
166CDK20.14667774
167CSNK1D0.14578429

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.14380410
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.67684001
3Protein export_Homo sapiens_hsa030604.20263278
4Insulin secretion_Homo sapiens_hsa049113.50081241
5Proteasome_Homo sapiens_hsa030502.70731509
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.57504988
7Regulation of autophagy_Homo sapiens_hsa041402.49870674
8Phototransduction_Homo sapiens_hsa047442.41463016
9Vibrio cholerae infection_Homo sapiens_hsa051102.40239089
10Homologous recombination_Homo sapiens_hsa034402.36728879
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.35876230
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.29109314
13Folate biosynthesis_Homo sapiens_hsa007902.28669520
14DNA replication_Homo sapiens_hsa030302.09852445
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04819911
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02187646
17Synaptic vesicle cycle_Homo sapiens_hsa047211.99700445
18Sulfur metabolism_Homo sapiens_hsa009201.96797903
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83507031
20Histidine metabolism_Homo sapiens_hsa003401.77896954
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67150295
22Circadian rhythm_Homo sapiens_hsa047101.64850725
23Mismatch repair_Homo sapiens_hsa034301.64826686
24Base excision repair_Homo sapiens_hsa034101.64388620
25Thyroid cancer_Homo sapiens_hsa052161.63691498
26Basal transcription factors_Homo sapiens_hsa030221.62658040
27Fatty acid elongation_Homo sapiens_hsa000621.62260748
28Taste transduction_Homo sapiens_hsa047421.51173538
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47654385
30Arginine and proline metabolism_Homo sapiens_hsa003301.47093190
31Vitamin digestion and absorption_Homo sapiens_hsa049771.45919109
32Phenylalanine metabolism_Homo sapiens_hsa003601.43811052
33Fanconi anemia pathway_Homo sapiens_hsa034601.35080340
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31307847
35Type II diabetes mellitus_Homo sapiens_hsa049301.29893095
36N-Glycan biosynthesis_Homo sapiens_hsa005101.29120318
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20920689
38Dopaminergic synapse_Homo sapiens_hsa047281.19974185
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18850909
40Hippo signaling pathway_Homo sapiens_hsa043901.18042973
41Cocaine addiction_Homo sapiens_hsa050301.16867514
42Glucagon signaling pathway_Homo sapiens_hsa049221.16541660
43Lysine degradation_Homo sapiens_hsa003101.16020166
44Ovarian steroidogenesis_Homo sapiens_hsa049131.15594707
45Dilated cardiomyopathy_Homo sapiens_hsa054141.12900267
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12549472
47Type I diabetes mellitus_Homo sapiens_hsa049401.12365033
48Nicotine addiction_Homo sapiens_hsa050331.12248232
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11105060
50Serotonergic synapse_Homo sapiens_hsa047261.09879396
51VEGF signaling pathway_Homo sapiens_hsa043701.04545799
52Collecting duct acid secretion_Homo sapiens_hsa049661.03950829
53Amphetamine addiction_Homo sapiens_hsa050311.01354376
54Basal cell carcinoma_Homo sapiens_hsa052171.00640686
55RNA polymerase_Homo sapiens_hsa030201.00456798
56beta-Alanine metabolism_Homo sapiens_hsa004100.99114161
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98326574
58Fatty acid degradation_Homo sapiens_hsa000710.95934631
59Lysosome_Homo sapiens_hsa041420.95431327
60Cell cycle_Homo sapiens_hsa041100.95133141
61ECM-receptor interaction_Homo sapiens_hsa045120.94540748
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94365362
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93678307
64Adherens junction_Homo sapiens_hsa045200.93200862
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92637201
66Oocyte meiosis_Homo sapiens_hsa041140.92393050
67Tyrosine metabolism_Homo sapiens_hsa003500.92131439
68ABC transporters_Homo sapiens_hsa020100.92119904
69TGF-beta signaling pathway_Homo sapiens_hsa043500.91504641
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.90145674
71Prolactin signaling pathway_Homo sapiens_hsa049170.89473828
72Prion diseases_Homo sapiens_hsa050200.89277771
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89117860
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88294818
75Nucleotide excision repair_Homo sapiens_hsa034200.87920746
76Insulin signaling pathway_Homo sapiens_hsa049100.86804572
77Nitrogen metabolism_Homo sapiens_hsa009100.84536842
78Thyroid hormone synthesis_Homo sapiens_hsa049180.83251303
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82612142
80Cholinergic synapse_Homo sapiens_hsa047250.81137795
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80825122
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79850501
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79731583
84Circadian entrainment_Homo sapiens_hsa047130.78528016
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75460537
86Vitamin B6 metabolism_Homo sapiens_hsa007500.74649720
87Estrogen signaling pathway_Homo sapiens_hsa049150.74149841
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.73320609
89Tight junction_Homo sapiens_hsa045300.72225302
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.69847450
91Phagosome_Homo sapiens_hsa041450.69676670
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.69159056
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.69114339
94RNA transport_Homo sapiens_hsa030130.68230395
95Bile secretion_Homo sapiens_hsa049760.68206049
96Glycerolipid metabolism_Homo sapiens_hsa005610.66975667
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.64950922
98Arachidonic acid metabolism_Homo sapiens_hsa005900.62961537
99Galactose metabolism_Homo sapiens_hsa000520.62897185
100Oxidative phosphorylation_Homo sapiens_hsa001900.60348194
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60250525
102Epstein-Barr virus infection_Homo sapiens_hsa051690.60084800
103Gap junction_Homo sapiens_hsa045400.59777245
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59397554
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58791005
106Calcium signaling pathway_Homo sapiens_hsa040200.58130757
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57910948
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57566414
109Pyruvate metabolism_Homo sapiens_hsa006200.56696068
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56650707
111Ribosome_Homo sapiens_hsa030100.55996170
112Pancreatic secretion_Homo sapiens_hsa049720.55438805
113Tryptophan metabolism_Homo sapiens_hsa003800.55409491
114Bladder cancer_Homo sapiens_hsa052190.55330664
115Other glycan degradation_Homo sapiens_hsa005110.55279573
116Sphingolipid metabolism_Homo sapiens_hsa006000.55178344
117Protein digestion and absorption_Homo sapiens_hsa049740.55177203
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54815659
119Inositol phosphate metabolism_Homo sapiens_hsa005620.53440272
120Fatty acid metabolism_Homo sapiens_hsa012120.51702734
121Renin secretion_Homo sapiens_hsa049240.51631973
122Huntingtons disease_Homo sapiens_hsa050160.51339584
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51190733
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49168787
125Endometrial cancer_Homo sapiens_hsa052130.49072328
126Notch signaling pathway_Homo sapiens_hsa043300.47813638
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.47227562
128Ether lipid metabolism_Homo sapiens_hsa005650.46815074
129Linoleic acid metabolism_Homo sapiens_hsa005910.46592217
130Hedgehog signaling pathway_Homo sapiens_hsa043400.46165735
131Selenocompound metabolism_Homo sapiens_hsa004500.45409097
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45195620
133mRNA surveillance pathway_Homo sapiens_hsa030150.44746603
134Fat digestion and absorption_Homo sapiens_hsa049750.42573792
135Purine metabolism_Homo sapiens_hsa002300.40920211
136Butanoate metabolism_Homo sapiens_hsa006500.40448801
137Fructose and mannose metabolism_Homo sapiens_hsa000510.39843510
138Melanoma_Homo sapiens_hsa052180.39592193
139Long-term potentiation_Homo sapiens_hsa047200.39558444
140p53 signaling pathway_Homo sapiens_hsa041150.39375433
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39181623
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38876982
143Parkinsons disease_Homo sapiens_hsa050120.38869070
144RNA degradation_Homo sapiens_hsa030180.38247286
145Alcoholism_Homo sapiens_hsa050340.37751352
146Melanogenesis_Homo sapiens_hsa049160.37646379
147cAMP signaling pathway_Homo sapiens_hsa040240.37540140
148Arginine biosynthesis_Homo sapiens_hsa002200.37327039
149GABAergic synapse_Homo sapiens_hsa047270.36520881
150Glutamatergic synapse_Homo sapiens_hsa047240.35046802
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34024599
152Wnt signaling pathway_Homo sapiens_hsa043100.33832514
153FoxO signaling pathway_Homo sapiens_hsa040680.32693974
154ErbB signaling pathway_Homo sapiens_hsa040120.30978446
155Salivary secretion_Homo sapiens_hsa049700.30957947
156Pyrimidine metabolism_Homo sapiens_hsa002400.30280623
157Choline metabolism in cancer_Homo sapiens_hsa052310.29771293
158Propanoate metabolism_Homo sapiens_hsa006400.29544607
159Dorso-ventral axis formation_Homo sapiens_hsa043200.29481175
160Legionellosis_Homo sapiens_hsa051340.29320992
161Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27062464
162Steroid biosynthesis_Homo sapiens_hsa001000.26891170
163Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26596405
164Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26283014
165Long-term depression_Homo sapiens_hsa047300.25611374

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