GFY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)7.59477876
2adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)7.37442441
3regulation of chromatin binding (GO:0035561)6.57045246
4axoneme assembly (GO:0035082)6.46554317
5protein polyglutamylation (GO:0018095)6.38619791
6axonemal dynein complex assembly (GO:0070286)6.37904964
7regulation of female gonad development (GO:2000194)6.26934424
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.00509864
9cilium movement (GO:0003341)5.65934130
10detection of calcium ion (GO:0005513)5.57873500
11peripheral nervous system neuron development (GO:0048935)5.52865747
12intraciliary transport (GO:0042073)5.50902009
13phosphorelay signal transduction system (GO:0000160)5.17574102
14DNA damage response, detection of DNA damage (GO:0042769)5.13549209
15cardiac right ventricle morphogenesis (GO:0003215)4.98970459
16regulation of DNA methylation (GO:0044030)4.98815326
17short-term memory (GO:0007614)4.97537526
18auditory receptor cell differentiation (GO:0042491)4.96763665
19antibacterial humoral response (GO:0019731)4.60785645
20regulation of microtubule-based movement (GO:0060632)4.55390227
21epithelial cilium movement (GO:0003351)4.46049703
22microtubule severing (GO:0051013)4.37683547
23dopamine receptor signaling pathway (GO:0007212)4.33097086
24natural killer cell mediated cytotoxicity (GO:0042267)4.31717619
25natural killer cell mediated immunity (GO:0002228)4.31717619
26microtubule bundle formation (GO:0001578)4.31363762
27chemosensory behavior (GO:0007635)4.24948757
28pyrimidine nucleobase catabolic process (GO:0006208)4.23368169
29antimicrobial humoral response (GO:0019730)4.22453329
30adipose tissue development (GO:0060612)4.18433517
31presynaptic membrane assembly (GO:0097105)4.14654932
32mating behavior (GO:0007617)4.13029348
33innate immune response in mucosa (GO:0002227)4.06591198
34postsynaptic membrane organization (GO:0001941)4.06225116
35positive regulation of mRNA processing (GO:0050685)4.04909594
36negative regulation of smooth muscle cell differentiation (GO:0051151)4.01887867
37olfactory bulb development (GO:0021772)4.00953149
38activation of protein kinase A activity (GO:0034199)4.00021984
39neural tube formation (GO:0001841)3.94559041
40cellular response to glucagon stimulus (GO:0071377)3.86936930
41neuron recognition (GO:0008038)3.85252063
42protein localization to synapse (GO:0035418)3.84092203
43negative regulation of cytosolic calcium ion concentration (GO:0051481)3.81865638
44generation of neurons (GO:0048699)3.78474440
45behavioral response to cocaine (GO:0048148)3.78109702
46single strand break repair (GO:0000012)3.77880211
47pre-miRNA processing (GO:0031054)3.76324958
48regulation of NFAT protein import into nucleus (GO:0051532)3.66455412
49presynaptic membrane organization (GO:0097090)3.65990615
50positive regulation of RNA splicing (GO:0033120)3.65452108
51negative regulation of translation, ncRNA-mediated (GO:0040033)3.64428211
52regulation of translation, ncRNA-mediated (GO:0045974)3.64428211
53negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.64428211
54protein heterotetramerization (GO:0051290)3.62129738
55neurotransmitter-gated ion channel clustering (GO:0072578)3.60735754
56cell migration in hindbrain (GO:0021535)3.58242010
57genitalia morphogenesis (GO:0035112)3.57737159
58regulation of sodium ion transmembrane transporter activity (GO:2000649)3.53155838
59detection of light stimulus involved in sensory perception (GO:0050962)3.52350687
60detection of light stimulus involved in visual perception (GO:0050908)3.52350687
61negative regulation of microtubule polymerization (GO:0031115)3.51531496
62central nervous system projection neuron axonogenesis (GO:0021952)3.51271607
63regulation of acrosome reaction (GO:0060046)3.49770744
64negative regulation of histone methylation (GO:0031061)3.49719235
65dendrite morphogenesis (GO:0048813)3.49517592
66response to caffeine (GO:0031000)3.43843103
67ovulation cycle (GO:0042698)3.43741600
68ventricular trabecula myocardium morphogenesis (GO:0003222)3.41944467
69cilium or flagellum-dependent cell motility (GO:0001539)3.39755565
70neuronal action potential (GO:0019228)3.38988236
71mucosal immune response (GO:0002385)3.38974815
72cAMP biosynthetic process (GO:0006171)3.38944086
73cellular copper ion homeostasis (GO:0006878)3.37430427
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.32135568
75nucleobase catabolic process (GO:0046113)3.32077303
76neuron cell-cell adhesion (GO:0007158)3.31980844
77regulation of heart rate by cardiac conduction (GO:0086091)3.30765381
78positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.29878209
79regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.29878209
80brain morphogenesis (GO:0048854)3.29088234
81* cilium morphogenesis (GO:0060271)3.28904294
82regulation of sodium ion transmembrane transport (GO:1902305)3.28875811
83potassium ion transmembrane transport (GO:0071805)3.26733970
84cellular potassium ion transport (GO:0071804)3.26733970
85axonal fasciculation (GO:0007413)3.25635214
86regulation of protein kinase A signaling (GO:0010738)3.25482950
87photoreceptor cell maintenance (GO:0045494)3.25071630
88calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.24984271
89multicellular organism reproduction (GO:0032504)3.22499923
90organ or tissue specific immune response (GO:0002251)3.21633916
91endocrine pancreas development (GO:0031018)3.18620706
92negative regulation of complement activation (GO:0045916)3.18347848
93glial cell proliferation (GO:0014009)3.15614199
94layer formation in cerebral cortex (GO:0021819)3.14408204
95glycogen catabolic process (GO:0005980)3.13573584
96positive regulation of mitochondrial fission (GO:0090141)3.12567498
97cilium assembly (GO:0042384)3.11203035
98negative regulation of transcription regulatory region DNA binding (GO:2000678)3.11189035
99synapse assembly (GO:0007416)3.09102869
100sensory perception of taste (GO:0050909)3.08925455
101positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05548380
102left/right axis specification (GO:0070986)3.05445593
103regulation of histone H3-K9 methylation (GO:0051570)3.04220704
104gamma-aminobutyric acid signaling pathway (GO:0007214)3.03723711
105regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03359617
106positive regulation of mRNA metabolic process (GO:1903313)3.03356532
107calcium-mediated signaling using intracellular calcium source (GO:0035584)3.02436963
108response to glucagon (GO:0033762)3.02122873
109regulation of sulfur metabolic process (GO:0042762)3.01180816
110startle response (GO:0001964)3.00316724
111* sensory perception of smell (GO:0007608)22.6640046
112behavioral response to nicotine (GO:0035095)2.99631180
113potassium ion transport (GO:0006813)2.99605577
114mRNA splice site selection (GO:0006376)2.97215779
115membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.96786395
116snRNA transcription (GO:0009301)2.96431172
117negative regulation of astrocyte differentiation (GO:0048712)2.95013862
118cilium organization (GO:0044782)2.94982188
119establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.91913434
120mitochondrion transport along microtubule (GO:0047497)2.91913434
121glucan catabolic process (GO:0009251)2.91876180
122hair cell differentiation (GO:0035315)2.90695723
123membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90584709
124* protein localization to cilium (GO:0061512)2.90050415
125regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.89744089
126positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.89744089
127facial nerve structural organization (GO:0021612)2.89305313
128modulation by virus of host process (GO:0019054)2.85881446
129meiotic cell cycle (GO:0051321)2.85380543
130chemical homeostasis within a tissue (GO:0048875)2.85362758
131spinal cord development (GO:0021510)2.85235821
132regulation of synaptic transmission, GABAergic (GO:0032228)2.83795896
133magnesium ion transport (GO:0015693)2.83641422
134limb bud formation (GO:0060174)2.83121697
135peptidyl-threonine dephosphorylation (GO:0035970)2.81123753
136cardiac conduction (GO:0061337)2.80592962
137regulation of penile erection (GO:0060405)2.80227881
138one-carbon compound transport (GO:0019755)2.79789090
139inner ear receptor cell differentiation (GO:0060113)2.79385322
140peptidyl-glutamic acid modification (GO:0018200)2.79087281
141female gonad development (GO:0008585)2.78695664
142centriole replication (GO:0007099)2.78508050
143neurogenesis (GO:0022008)2.77114751
144cardiac ventricle formation (GO:0003211)2.76947585
145regulation of action potential (GO:0098900)2.76626773
146positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76055503
147negative regulation of membrane potential (GO:0045837)2.75254119
148positive regulation of dendritic spine development (GO:0060999)2.74611846
149negative regulation of humoral immune response (GO:0002921)2.74600991
150positive regulation of mRNA 3-end processing (GO:0031442)2.73736258
151melanosome transport (GO:0032402)2.73049714
152ionotropic glutamate receptor signaling pathway (GO:0035235)2.72842800
153ADP metabolic process (GO:0046031)2.72395240
154heart field specification (GO:0003128)2.71309852
155secondary heart field specification (GO:0003139)2.71309852
156ganglion development (GO:0061548)2.71285475
157establishment of mitochondrion localization (GO:0051654)2.70968046
158regulation of dopamine secretion (GO:0014059)2.70662976
159atrial cardiac muscle cell action potential (GO:0086014)2.69906169
160connective tissue development (GO:0061448)2.69062839
161ventricular system development (GO:0021591)2.68546890
162piRNA metabolic process (GO:0034587)2.68308106
163regulation of short-term neuronal synaptic plasticity (GO:0048172)2.68187384
164negative regulation of protein activation cascade (GO:2000258)2.66507352
165response to amphetamine (GO:0001975)2.65592815
166regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65553124
167positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.65333749
168regulation of sodium ion transport (GO:0002028)2.64895026
169forebrain neuron development (GO:0021884)2.64511239
170histone H2B ubiquitination (GO:0033523)2.63219799
171binding of sperm to zona pellucida (GO:0007339)2.62830247
172DNA methylation involved in gamete generation (GO:0043046)2.62578970
173acrosome assembly (GO:0001675)2.61936530
174cardiac chamber formation (GO:0003207)2.61800802
175cellular polysaccharide catabolic process (GO:0044247)2.61521269
176sympathetic nervous system development (GO:0048485)2.60112797
177regulation of female receptivity (GO:0045924)2.59829599
178alternative mRNA splicing, via spliceosome (GO:0000380)2.59691459
179neurofilament cytoskeleton organization (GO:0060052)2.59647974
180female mating behavior (GO:0060180)2.59257049
181positive regulation of protein export from nucleus (GO:0046827)2.58882197
182neuronal ion channel clustering (GO:0045161)2.56926873
183neuron migration (GO:0001764)2.56198559
184regulation of smooth muscle cell differentiation (GO:0051150)2.52871133
185regulation of dendritic spine morphogenesis (GO:0061001)2.52429940
186gene silencing by RNA (GO:0031047)2.51790503
187positive regulation of dendritic spine morphogenesis (GO:0061003)2.51353841
188DNA alkylation (GO:0006305)2.51113639
189DNA methylation (GO:0006306)2.51113639
190* sensory perception of chemical stimulus (GO:0007606)13.1770226
191protein insertion into membrane (GO:0051205)11.5244187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.44430785
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.84869685
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.71150820
4ZNF263_19887448_ChIP-Seq_K562_Human3.29352098
5DROSHA_22980978_ChIP-Seq_HELA_Human3.02572280
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.86647438
7ESR1_15608294_ChIP-ChIP_MCF-7_Human2.71174966
8TAF15_26573619_Chip-Seq_HEK293_Human2.34203055
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32871642
10BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.27583923
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.25163572
12VDR_22108803_ChIP-Seq_LS180_Human2.18113392
13GBX2_23144817_ChIP-Seq_PC3_Human2.17300343
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.13767323
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00629765
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00629765
17LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00359506
18IGF1R_20145208_ChIP-Seq_DFB_Human1.92177420
19RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.90961719
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.85799983
21ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.83736225
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83106490
23AHR_22903824_ChIP-Seq_MCF-7_Human1.79520965
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.78280880
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.77787617
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73208664
27KDM2B_26808549_Chip-Seq_K562_Human1.72270145
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.70737934
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68830447
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62688374
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62331281
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60637983
33ZNF274_21170338_ChIP-Seq_K562_Hela1.59957677
34IRF1_19129219_ChIP-ChIP_H3396_Human1.56933064
35FUS_26573619_Chip-Seq_HEK293_Human1.55773333
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52209289
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.49694338
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48350681
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47170004
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45671831
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44510540
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44510540
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42699187
44CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42457531
45EWS_26573619_Chip-Seq_HEK293_Human1.42063574
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40965411
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40590715
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39373786
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37559935
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.37283357
51RNF2_27304074_Chip-Seq_NSC_Mouse1.36163411
52REST_21632747_ChIP-Seq_MESCs_Mouse1.36127486
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34989183
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34843441
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34098735
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33292048
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32820959
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32404896
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30181314
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30109775
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29782059
62CBP_20019798_ChIP-Seq_JUKART_Human1.28347994
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28347994
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28228550
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28212934
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28116798
67LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26931347
68AR_25329375_ChIP-Seq_VCAP_Human1.25180342
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.24705659
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23672203
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.23444878
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22642801
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22178022
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.21745870
75OCT4_20526341_ChIP-Seq_ESCs_Human1.21681957
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21273514
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19737286
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.18895071
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17095712
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15568192
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15038796
82STAT1_20625510_ChIP-Seq_HELA_Human1.11778592
83AR_21572438_ChIP-Seq_LNCaP_Human1.10920131
84E2F1_20622854_ChIP-Seq_HELA_Human1.10429073
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10093596
86GATA3_27048872_Chip-Seq_THYMUS_Human1.07960091
87CTCF_20526341_ChIP-Seq_ESCs_Human1.07766062
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07366146
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06932429
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.05646253
91RARB_27405468_Chip-Seq_BRAIN_Mouse1.05003049
92STAT3_18555785_ChIP-Seq_MESCs_Mouse1.04889719
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04395134
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03708310
95SOX9_26525672_Chip-Seq_HEART_Mouse1.02346282
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02284693
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02109899
98SMAD4_21799915_ChIP-Seq_A2780_Human1.01608451
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01384355
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99760186
101EZH2_27304074_Chip-Seq_ESCs_Mouse0.99394718
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.98082448
103TP53_20018659_ChIP-ChIP_R1E_Mouse0.98038038
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97976813
105ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97853580
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97008850
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96594433
108SMAD3_21741376_ChIP-Seq_EPCs_Human0.96273852
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96214491
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96134417
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95904479
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.95723696
113GF1_26923725_Chip-Seq_HPCs_Mouse0.95178942
114STAT3_23295773_ChIP-Seq_U87_Human0.95145253
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95071818
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94821440
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94416088
118TCF4_23295773_ChIP-Seq_U87_Human0.94119616
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94035604
120ER_23166858_ChIP-Seq_MCF-7_Human0.93898121
121NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.93009355
122P300_19829295_ChIP-Seq_ESCs_Human0.92784650
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92707192
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92071194
125LXR_22292898_ChIP-Seq_THP-1_Human0.91797635
126ERA_21632823_ChIP-Seq_H3396_Human0.90940593
127CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90896812
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.90630285
129PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90546402
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.90506576
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90215739
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89873013
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89849333
134TP53_22573176_ChIP-Seq_HFKS_Human0.89206296
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88948084
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88948084
137KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88948084
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88764567
139RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88742861
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87511831
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87317680
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86488013
143FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86385770
144REST_18959480_ChIP-ChIP_MESCs_Mouse0.85558885
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.85492387
146ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84438224
147NANOG_20526341_ChIP-Seq_ESCs_Human0.83248324
148TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83045331
149EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82909283
150TAL1_26923725_Chip-Seq_HPCs_Mouse0.82548363
151CTCF_27219007_Chip-Seq_Bcells_Human0.82180119
152GATA3_21867929_ChIP-Seq_CD8_Mouse0.80316167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium4.78521113
2MP0005499_abnormal_olfactory_system4.74706053
3MP0005394_taste/olfaction_phenotype4.74706053
4MP0003806_abnormal_nucleotide_metabolis3.05911747
5MP0003890_abnormal_embryonic-extraembry2.78254899
6MP0003718_maternal_effect2.70410917
7MP0005645_abnormal_hypothalamus_physiol2.66757441
8MP0001485_abnormal_pinna_reflex2.59214837
9MP0002184_abnormal_innervation2.19716770
10MP0005377_hearing/vestibular/ear_phenot2.17784023
11MP0003878_abnormal_ear_physiology2.17784023
12MP0001984_abnormal_olfaction15.3445809
13MP0008877_abnormal_DNA_methylation1.94790404
14MP0002653_abnormal_ependyma_morphology1.91075578
15MP0006292_abnormal_olfactory_placode1.87436768
16MP0002160_abnormal_reproductive_system1.73022531
17MP0008875_abnormal_xenobiotic_pharmacok1.69892803
18MP0002735_abnormal_chemical_nociception1.69295601
19MP0008058_abnormal_DNA_repair1.59935489
20MP0008995_early_reproductive_senescence1.59898529
21MP0000955_abnormal_spinal_cord1.47882566
22MP0003943_abnormal_hepatobiliary_system1.44838293
23MP0000372_irregular_coat_pigmentation1.44457721
24MP0005410_abnormal_fertilization1.43926142
25MP0009046_muscle_twitch1.43339077
26MP0003121_genomic_imprinting1.41933779
27MP0002752_abnormal_somatic_nervous1.38784840
28MP0001542_abnormal_bone_strength1.37894473
29MP0002697_abnormal_eye_size1.32445592
30MP0001919_abnormal_reproductive_system1.30936332
31MP0002233_abnormal_nose_morphology1.29042240
32MP0002234_abnormal_pharynx_morphology1.27278239
33MP0000566_synostosis1.26754636
34MP0002928_abnormal_bile_duct1.25686532
35MP0002877_abnormal_melanocyte_morpholog1.25045451
36MP0001324_abnormal_eye_pigmentation1.24224090
37MP0004145_abnormal_muscle_electrophysio1.22318565
38MP0001486_abnormal_startle_reflex1.21015527
39MP0002557_abnormal_social/conspecific_i1.19430737
40MP0002733_abnormal_thermal_nociception1.19173373
41MP0003699_abnormal_female_reproductive1.16787429
42MP0001879_abnormal_lymphatic_vessel1.15858657
43MP0001529_abnormal_vocalization1.15253038
44MP0002822_catalepsy1.14932998
45MP0000647_abnormal_sebaceous_gland1.12561047
46MP0002161_abnormal_fertility/fecundity1.10520191
47MP0005623_abnormal_meninges_morphology1.09433615
48MP0002882_abnormal_neuron_morphology1.06735519
49MP0003646_muscle_fatigue1.05887918
50MP0000653_abnormal_sex_gland1.05395294
51MP0000516_abnormal_urinary_system1.03066980
52MP0005367_renal/urinary_system_phenotyp1.03066980
53MP0005646_abnormal_pituitary_gland1.03028967
54MP0002734_abnormal_mechanical_nocicepti1.02665706
55MP0004742_abnormal_vestibular_system1.00559272
56MP0002272_abnormal_nervous_system1.00192769
57MP0006072_abnormal_retinal_apoptosis0.98997282
58MP0003252_abnormal_bile_duct0.98805653
59MP0004858_abnormal_nervous_system0.97656952
60MP0001286_abnormal_eye_development0.95044083
61MP0010234_abnormal_vibrissa_follicle0.94316010
62MP0004142_abnormal_muscle_tone0.93759083
63MP0001502_abnormal_circadian_rhythm0.93439234
64MP0005551_abnormal_eye_electrophysiolog0.93344923
65MP0000778_abnormal_nervous_system0.92771666
66MP0002736_abnormal_nociception_after0.92651599
67MP0005084_abnormal_gallbladder_morpholo0.91820417
68MP0004270_analgesia0.91486365
69MP0001929_abnormal_gametogenesis0.91081046
70MP0003635_abnormal_synaptic_transmissio0.89913115
71MP0005395_other_phenotype0.88502988
72MP0001119_abnormal_female_reproductive0.87047473
73MP0009333_abnormal_splenocyte_physiolog0.85540198
74MP0008932_abnormal_embryonic_tissue0.84567033
75MP0003119_abnormal_digestive_system0.84279768
76MP0001293_anophthalmia0.84138111
77MP0006035_abnormal_mitochondrial_morpho0.83853197
78MP0005083_abnormal_biliary_tract0.83249450
79MP0002102_abnormal_ear_morphology0.82978197
80MP0000003_abnormal_adipose_tissue0.82948093
81MP0005174_abnormal_tail_pigmentation0.82024589
82MP0001968_abnormal_touch/_nociception0.80795665
83MP0003567_abnormal_fetal_cardiomyocyte0.80316204
84MP0003787_abnormal_imprinting0.79799465
85MP0004085_abnormal_heartbeat0.78257727
86MP0002152_abnormal_brain_morphology0.78236946
87MP0001145_abnormal_male_reproductive0.77174950
88MP0002063_abnormal_learning/memory/cond0.77019021
89MP0005389_reproductive_system_phenotype0.74223172
90MP0001501_abnormal_sleep_pattern0.74017407
91MP0003221_abnormal_cardiomyocyte_apopto0.72791910
92MP0001963_abnormal_hearing_physiology0.72537400
93MP0002229_neurodegeneration0.70247361
94MP0008770_decreased_survivor_rate0.69707707
95MP0004811_abnormal_neuron_physiology0.69339072
96MP0000026_abnormal_inner_ear0.65677798
97MP0002909_abnormal_adrenal_gland0.64709142
98MP0002572_abnormal_emotion/affect_behav0.62178027
99MP0006276_abnormal_autonomic_nervous0.59996247
100MP0005187_abnormal_penis_morphology0.59417386
101MP0005423_abnormal_somatic_nervous0.58049596
102MP0003942_abnormal_urinary_system0.56913789
103MP0002896_abnormal_bone_mineralization0.56496005
104MP0003861_abnormal_nervous_system0.53864521
105MP0000631_abnormal_neuroendocrine_gland0.53658133
106MP0004133_heterotaxia0.53512625
107MP0005195_abnormal_posterior_eye0.52620352
108MP0002067_abnormal_sensory_capabilities0.52462383
109MP0001188_hyperpigmentation0.51328943
110MP0003634_abnormal_glial_cell0.49299450
111MP0004782_abnormal_surfactant_physiolog0.49298440
112MP0003880_abnormal_central_pattern0.47977996
113MP0000049_abnormal_middle_ear0.47467525
114MP0002295_abnormal_pulmonary_circulatio0.44731140
115MP0002092_abnormal_eye_morphology0.43859530
116MP0005584_abnormal_enzyme/coenzyme_acti0.43188791
117MP0004859_abnormal_synaptic_plasticity0.42248881
118MP0005365_abnormal_bile_salt0.42093904
119MP0002751_abnormal_autonomic_nervous0.41870246
120MP0003693_abnormal_embryo_hatching0.41550305
121MP0010352_gastrointestinal_tract_polyps0.40636222
122MP0002064_seizures0.38660487
123MP0003879_abnormal_hair_cell0.37522059
124MP0001970_abnormal_pain_threshold0.36341764
125MP0008874_decreased_physiological_sensi0.36214474
126MP0010386_abnormal_urinary_bladder0.36160422
127MP0010030_abnormal_orbit_morphology0.35721449
128MP0003698_abnormal_male_reproductive0.35031238
129MP0009745_abnormal_behavioral_response0.34794779
130MP0002210_abnormal_sex_determination0.33998234
131MP0000534_abnormal_ureter_morphology0.33833200
132MP0004147_increased_porphyrin_level0.32537668
133MP0001346_abnormal_lacrimal_gland0.31229102
134MP0000613_abnormal_salivary_gland0.30761935
135MP0010770_preweaning_lethality0.30456362
136MP0002082_postnatal_lethality0.30456362
137MP0002098_abnormal_vibrissa_morphology0.30275507
138MP0004134_abnormal_chest_morphology0.27210508
139MP0010769_abnormal_survival0.26883766
140MP0002081_perinatal_lethality0.26499645
141MP0002938_white_spotting0.26054847
142MP0002066_abnormal_motor_capabilities/c0.25866521
143MP0000538_abnormal_urinary_bladder0.25476990
144MP0003938_abnormal_ear_development0.25428170
145MP0003633_abnormal_nervous_system0.25386302

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.89885329
2Rhinitis (HP:0012384)7.16605924
3Abnormal respiratory epithelium morphology (HP:0012253)6.97799822
4Abnormal respiratory motile cilium morphology (HP:0005938)6.97799822
5Abnormal ciliary motility (HP:0012262)6.77885369
6Retinal dysplasia (HP:0007973)6.31280596
7Chronic bronchitis (HP:0004469)5.51005548
8Abnormality of macular pigmentation (HP:0008002)5.18375688
9Limb dystonia (HP:0002451)5.15376266
10Bony spicule pigmentary retinopathy (HP:0007737)5.00905266
11Palpitations (HP:0001962)4.29065079
12Abnormality of midbrain morphology (HP:0002418)4.26912451
13Molar tooth sign on MRI (HP:0002419)4.26912451
14Osteomalacia (HP:0002749)4.25386234
15Bronchiectasis (HP:0002110)4.19605633
16Oligodactyly (hands) (HP:0001180)4.06460055
17Absent/shortened dynein arms (HP:0200106)4.03221054
18Dynein arm defect of respiratory motile cilia (HP:0012255)4.03221054
19Hypothermia (HP:0002045)3.93500513
20Dysphonia (HP:0001618)3.89080914
21Bifid tongue (HP:0010297)3.84650690
22Atonic seizures (HP:0010819)3.76070872
23Cortical dysplasia (HP:0002539)3.73765386
24Volvulus (HP:0002580)3.72998817
25Hypochromic microcytic anemia (HP:0004840)3.71244358
26Lissencephaly (HP:0001339)3.66018584
27Gait imbalance (HP:0002141)3.52233883
28Abnormality of dentin (HP:0010299)3.50265221
29Congenital primary aphakia (HP:0007707)3.41770965
30Syncope (HP:0001279)3.23856711
31Anosmia (HP:0000458)3.22003338
32Diplopia (HP:0000651)3.21573797
33Abnormality of binocular vision (HP:0011514)3.21573797
34Nephrogenic diabetes insipidus (HP:0009806)3.18786468
35Medial flaring of the eyebrow (HP:0010747)3.16221927
36Myokymia (HP:0002411)3.09816327
37Abnormality of the labia minora (HP:0012880)3.08493757
38Peripheral hypomyelination (HP:0007182)3.07929112
39Febrile seizures (HP:0002373)3.04113519
40Nephronophthisis (HP:0000090)3.02966792
41Proximal tubulopathy (HP:0000114)3.02829848
42Nasal polyposis (HP:0100582)2.95096376
43Postaxial hand polydactyly (HP:0001162)2.85739916
44Abnormality of sodium homeostasis (HP:0010931)2.79341420
45Male infertility (HP:0003251)2.78918206
46Chronic hepatic failure (HP:0100626)2.77864202
47Short nail (HP:0001799)2.77630059
48Oligodactyly (HP:0012165)2.76805561
49Gonadotropin excess (HP:0000837)2.76737335
50Torticollis (HP:0000473)2.76036160
51Poikilocytosis (HP:0004447)2.75017007
52Recurrent sinusitis (HP:0011108)2.73189849
53Abnormality of abdominal situs (HP:0011620)2.71420684
54Abdominal situs inversus (HP:0003363)2.71420684
55Chronic sinusitis (HP:0011109)2.66669898
56Vaginal atresia (HP:0000148)2.64019459
57Recurrent otitis media (HP:0000403)2.62666556
58Labial hypoplasia (HP:0000066)2.60380118
59Poor coordination (HP:0002370)2.60004351
60True hermaphroditism (HP:0010459)2.58245132
61Pancreatic fibrosis (HP:0100732)2.55599442
62Amblyopia (HP:0000646)2.55508991
63Genital tract atresia (HP:0001827)2.54201511
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.53873005
65Prolonged QT interval (HP:0001657)2.51864569
66Birth length less than 3rd percentile (HP:0003561)2.51420093
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51046406
68Cholecystitis (HP:0001082)2.50892311
69Abnormal gallbladder physiology (HP:0012438)2.50892311
70Median cleft lip (HP:0000161)2.49396827
71Aplasia/Hypoplasia of the lens (HP:0008063)2.48978549
72Craniofacial dystonia (HP:0012179)2.45842455
73Genetic anticipation (HP:0003743)2.44708000
74Hypoplastic female external genitalia (HP:0012815)2.44677313
75Xerostomia (HP:0000217)2.43264794
76Bronchitis (HP:0012387)2.42819993
77Cystic liver disease (HP:0006706)2.39827383
78Tubulointerstitial nephritis (HP:0001970)2.38800754
79Hyperventilation (HP:0002883)2.38250123
80Occipital encephalocele (HP:0002085)2.35611823
81Pachygyria (HP:0001302)2.30336382
82Abnormality of the nasal mucosa (HP:0000433)2.28917340
83Abnormality of the renal medulla (HP:0100957)2.28837119
84Absence seizures (HP:0002121)2.28307553
85Progressive cerebellar ataxia (HP:0002073)2.27851709
86Abolished electroretinogram (ERG) (HP:0000550)2.26278645
87Abnormality of the labia (HP:0000058)2.26043483
88Pendular nystagmus (HP:0012043)2.24285430
89Aplasia/Hypoplasia of the brainstem (HP:0007362)2.22708352
90Hypoplasia of the brainstem (HP:0002365)2.22708352
91Focal dystonia (HP:0004373)2.22461458
92Failure to thrive in infancy (HP:0001531)2.22198550
93Patellar aplasia (HP:0006443)2.21333709
94Broad-based gait (HP:0002136)2.21018174
95Central scotoma (HP:0000603)2.19773156
96Retinitis pigmentosa (HP:0000510)2.19189814
97Oculomotor apraxia (HP:0000657)2.18964068
98Constricted visual fields (HP:0001133)2.18227872
99Abnormality of the dental root (HP:0006486)2.17403356
100Taurodontia (HP:0000679)2.17403356
101Abnormality of permanent molar morphology (HP:0011071)2.17403356
102Partial agenesis of the corpus callosum (HP:0001338)2.14468956
103Ventricular fibrillation (HP:0001663)2.13547532
104Narrow nasal bridge (HP:0000446)2.11656855
105Anencephaly (HP:0002323)2.09342558
106Stenosis of the external auditory canal (HP:0000402)2.08050207
107Abnormality of molar (HP:0011077)2.07818752
108Abnormality of molar morphology (HP:0011070)2.07818752
109Pancreatic cysts (HP:0001737)2.04732849
110Polymicrogyria (HP:0002126)2.04208613
111Impulsivity (HP:0100710)2.03633901
112Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4856977
113Sclerocornea (HP:0000647)1.98518914
114Termporal pattern (HP:0011008)1.97865527
115Insidious onset (HP:0003587)1.97865527
116Abnormality of the dental pulp (HP:0006479)1.93837352
117Neoplasm of the oral cavity (HP:0100649)1.93256600
118Slow-growing hair (HP:0002217)1.92978311
119Abnormality of hair growth rate (HP:0011363)1.92978311
120Abnormality of the lower motor neuron (HP:0002366)1.92564449
121Wrist flexion contracture (HP:0001239)1.92381348
122Bradycardia (HP:0001662)1.91156562
123Aplasia/Hypoplasia of the patella (HP:0006498)1.90948404
124Exotropia (HP:0000577)1.90784466
125Preaxial hand polydactyly (HP:0001177)1.89329948
126Abnormality of the diencephalon (HP:0010662)1.85730204
127Progressive inability to walk (HP:0002505)1.84755080
128Abnormal rod and cone electroretinograms (HP:0008323)1.84394065
129Reticulocytosis (HP:0001923)1.83990651
130Primary amenorrhea (HP:0000786)1.83909531
131Postaxial foot polydactyly (HP:0001830)1.83043908
132Specific learning disability (HP:0001328)1.82789435
133Split foot (HP:0001839)1.82522103
134Urinary bladder sphincter dysfunction (HP:0002839)1.78272085
135Protruding tongue (HP:0010808)1.76899779
136Abnormality of the astrocytes (HP:0100707)1.76470215
137Astrocytoma (HP:0009592)1.76470215
138Sudden death (HP:0001699)1.76347951
139Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76166914
140Diminished motivation (HP:0000745)1.76151245
141Severe visual impairment (HP:0001141)1.75662582
142Abnormal EKG (HP:0003115)1.74806860
143Apathy (HP:0000741)1.74560400
144Erectile abnormalities (HP:0100639)1.73177127
145Restlessness (HP:0000711)1.72490367
146Complete atrioventricular canal defect (HP:0001674)1.72433886
147Impaired vibration sensation in the lower limbs (HP:0002166)1.72389940
148Esotropia (HP:0000565)1.72083104
149Congenital hepatic fibrosis (HP:0002612)1.71502892
150Obsessive-compulsive behavior (HP:0000722)1.71214315
151Type II lissencephaly (HP:0007260)1.70844886
152Hyperglycinemia (HP:0002154)1.70777021
153Bell-shaped thorax (HP:0001591)1.70311997
154Myelomeningocele (HP:0002475)1.70060430
155Premature ovarian failure (HP:0008209)1.69887025
156Anterior segment dysgenesis (HP:0007700)1.69722259
157Decreased circulating renin level (HP:0003351)1.69379786
158Truncal obesity (HP:0001956)1.68874461
159Infertility (HP:0000789)1.68196334
160Furrowed tongue (HP:0000221)1.68099689
161Humeroradial synostosis (HP:0003041)1.67952532
162Synostosis involving the elbow (HP:0003938)1.67952532
163Dialeptic seizures (HP:0011146)1.67265360
164Chromsome breakage (HP:0040012)1.67039654
165Papillary thyroid carcinoma (HP:0002895)1.66972091
166Facial cleft (HP:0002006)1.65619966
167Cutaneous finger syndactyly (HP:0010554)1.65396372
168Hypotelorism (HP:0000601)1.65101381
169Abnormality of calcium-phosphate metabolism (HP:0100530)1.63976685
170Primary atrial arrhythmia (HP:0001692)1.63944740
171Gaze-evoked nystagmus (HP:0000640)1.63392730
172Left ventricular hypertrophy (HP:0001712)1.62861845
173Aplasia/Hypoplasia of the nipples (HP:0006709)1.62530362
174Congenital diaphragmatic hernia (HP:0000776)1.62524473
175Heterotopia (HP:0002282)1.61584440
176Micropenis (HP:0000054)1.61531610
177Renal hypoplasia (HP:0000089)1.60252179
178Homocystinuria (HP:0002156)1.58501106
179Abnormality of homocysteine metabolism (HP:0010919)1.58501106
180Abnormality of the fovea (HP:0000493)1.58437811
181Highly arched eyebrow (HP:0002553)1.57778749
182Aplasia/Hypoplasia of the tongue (HP:0010295)1.56931017
183Breast aplasia (HP:0100783)1.56834671
184Confusion (HP:0001289)1.56329218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK9.46224121
2PHKG15.97034898
3PHKG25.97034898
4MAPK154.60598593
5PKN24.14510231
6ERBB33.87456760
7ARAF3.63059901
8EEF2K2.99870286
9MAPKAPK32.66803083
10FLT32.65990983
11MAP3K92.64103166
12RIPK12.60003517
13ICK2.52215140
14PAK32.32179064
15DYRK22.16369309
16NUAK12.05499545
17CAMK2D2.05204068
18CAMK2B2.01305716
19PIM22.01147207
20TRIB31.98395611
21DAPK21.89485274
22CSNK1A1L1.73044930
23CAMK2G1.68788822
24STK161.65900065
25STK241.62150131
26STK38L1.61594802
27NEK21.53051427
28CSNK1G31.48373500
29SIK21.37996255
30HIPK21.35424868
31CSNK1G21.27614397
32TRIM281.23275626
33CSNK1G11.23066680
34BRAF1.22183791
35PINK11.20456133
36CAMK1G1.20443333
37CAMK1D1.15208294
38RPS6KA21.14704371
39TYRO31.12063467
40MAPK131.06000320
41PRPF4B1.01255481
42NTRK31.01035894
43CAMKK21.00085629
44DYRK30.98719713
45CDC70.97185595
46STK390.96841192
47PRKCG0.86468880
48TRPM70.82997253
49DYRK1B0.80970573
50TESK20.79065510
51ILK0.78756740
52STK380.77082866
53CDK120.76762974
54DAPK10.74719564
55DMPK0.72643810
56MAP2K70.72376738
57PRKD30.72131949
58SIK30.72122475
59BCR0.70610984
60RPS6KA40.69692072
61MAPKAPK50.68724793
62NTRK10.67956602
63MAP3K100.67420626
64BMPR20.66406298
65CLK10.65176135
66TESK10.64998543
67INSRR0.64543710
68TNK20.62813397
69MARK10.61041343
70MINK10.60987026
71NTRK20.56473947
72FRK0.56082404
73MAP3K20.55837169
74GRK50.55011877
75GRK60.54880309
76MAPKAPK20.54711971
77RET0.54081489
78TGFBR20.53836513
79AKT30.53267780
80MAP3K40.52479978
81PLK10.51612181
82CAMK2A0.49762941
83MAPK40.48983700
84CHUK0.47239491
85MAP3K130.45723009
86DYRK1A0.45468638
87MAPK90.44572122
88CAMKK10.44162510
89NME10.43143054
90KSR10.42704427
91CASK0.42520666
92CDK10.42333113
93DDR20.41752877
94CDK20.39890338
95LMTK20.39853542
96CSNK1E0.39148916
97MAPK110.38360748
98RAF10.35894506
99MAP3K30.35229071
100IRAK10.34868246
101FER0.34586646
102FGFR10.34005073
103ATM0.33274536
104PRKCE0.33216818
105TSSK60.33170338
106SGK4940.32821943
107SGK2230.32821943
108GRK10.32327422
109CSNK2A20.31398260
110CAMK40.31292334
111CSNK1D0.30001047
112GSK3B0.29929362
113CDK180.29167790
114PLK20.28913406
115CDK140.28774958
116CHEK10.27979892
117PRKAA20.27692719
118CSNK2A10.26613495
119ATR0.26454785
120AKT20.26394034
121PRKCZ0.25791686
122PLK40.25528864
123AURKA0.25513982
124CDK30.25465797
125CDK150.25351314
126PRKACA0.23670084
127CDK11A0.23492928
128PRKCQ0.23386617
129RPS6KA60.23215632
130TTK0.23203680
131PRKAA10.23200940
132RPS6KA10.23174272
133MAP3K50.22613690
134NLK0.22113914
135RPS6KA30.20908941
136CDK50.20488560
137MAPK70.19880150
138EGFR0.19836228
139WNK30.19269041
140MAPK100.19262216
141MAPK140.19246067
142PRKDC0.19126080
143EIF2AK30.18947388
144PRKD10.18899669
145PKN10.18898478
146RPS6KB10.18266398
147SGK20.18165323
148MAP2K40.16801253
149PRKG10.16758360
150FYN0.16713036
151WNK40.16692043
152MUSK0.16603273
153PRKCI0.15758287
154PTK2B0.15220621
155RPS6KL10.14768624
156RPS6KC10.14768624
157RPS6KB20.14413601
158CDK70.14304466

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.36575394
2Phototransduction_Homo sapiens_hsa047443.34093953
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21400286
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.02830044
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.20962711
6Olfactory transduction_Homo sapiens_hsa0474011.8322947
7Mismatch repair_Homo sapiens_hsa034301.99996638
8Basal transcription factors_Homo sapiens_hsa030221.97837778
9Morphine addiction_Homo sapiens_hsa050321.90727922
10Taste transduction_Homo sapiens_hsa047421.83574320
11Base excision repair_Homo sapiens_hsa034101.80094306
12Circadian entrainment_Homo sapiens_hsa047131.74036764
13Insulin secretion_Homo sapiens_hsa049111.62777507
14Basal cell carcinoma_Homo sapiens_hsa052171.61832348
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56162564
16Dopaminergic synapse_Homo sapiens_hsa047281.48681785
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48469639
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48007295
19Thyroid hormone synthesis_Homo sapiens_hsa049181.40763223
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40246884
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36768568
22GABAergic synapse_Homo sapiens_hsa047271.35351526
23Cell cycle_Homo sapiens_hsa041101.33980588
24Histidine metabolism_Homo sapiens_hsa003401.32959961
25Cholinergic synapse_Homo sapiens_hsa047251.32298850
26cAMP signaling pathway_Homo sapiens_hsa040241.31978220
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30910726
28beta-Alanine metabolism_Homo sapiens_hsa004101.29551086
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28512280
30Hippo signaling pathway_Homo sapiens_hsa043901.27727856
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27418546
32Glutamatergic synapse_Homo sapiens_hsa047241.26022612
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24531732
34Type II diabetes mellitus_Homo sapiens_hsa049301.24123506
35Vibrio cholerae infection_Homo sapiens_hsa051101.22323934
36Salivary secretion_Homo sapiens_hsa049701.21374291
37Gastric acid secretion_Homo sapiens_hsa049711.18408972
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12943566
39Collecting duct acid secretion_Homo sapiens_hsa049661.10274676
40Wnt signaling pathway_Homo sapiens_hsa043101.09158941
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09064121
42DNA replication_Homo sapiens_hsa030301.07822250
43Ovarian steroidogenesis_Homo sapiens_hsa049131.07584053
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05748303
45Huntingtons disease_Homo sapiens_hsa050161.05644452
46One carbon pool by folate_Homo sapiens_hsa006701.05451561
47Bile secretion_Homo sapiens_hsa049761.03042934
48Fanconi anemia pathway_Homo sapiens_hsa034601.02175818
49mRNA surveillance pathway_Homo sapiens_hsa030151.01155328
50Non-homologous end-joining_Homo sapiens_hsa034500.98232488
51Oxidative phosphorylation_Homo sapiens_hsa001900.97731715
52ErbB signaling pathway_Homo sapiens_hsa040120.96229102
53Synaptic vesicle cycle_Homo sapiens_hsa047210.95264495
54Alcoholism_Homo sapiens_hsa050340.93544668
55Thyroid cancer_Homo sapiens_hsa052160.90324906
56Estrogen signaling pathway_Homo sapiens_hsa049150.87012870
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.86941179
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84835913
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84361788
60Fatty acid biosynthesis_Homo sapiens_hsa000610.83110518
61Calcium signaling pathway_Homo sapiens_hsa040200.82777963
62Folate biosynthesis_Homo sapiens_hsa007900.82398544
63Pyruvate metabolism_Homo sapiens_hsa006200.79737232
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79165777
65Hedgehog signaling pathway_Homo sapiens_hsa043400.77872889
66RNA transport_Homo sapiens_hsa030130.76560198
67Glucagon signaling pathway_Homo sapiens_hsa049220.76414497
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75975836
69Adherens junction_Homo sapiens_hsa045200.75430825
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73168960
71RNA degradation_Homo sapiens_hsa030180.72115439
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71229934
73Selenocompound metabolism_Homo sapiens_hsa004500.71170755
74RNA polymerase_Homo sapiens_hsa030200.70877968
75Amphetamine addiction_Homo sapiens_hsa050310.70696212
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70004912
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69806030
78Renin secretion_Homo sapiens_hsa049240.69542856
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69513470
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.68958043
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68823671
82GnRH signaling pathway_Homo sapiens_hsa049120.68605067
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67519992
84ABC transporters_Homo sapiens_hsa020100.67062917
85Serotonergic synapse_Homo sapiens_hsa047260.66904549
86Inositol phosphate metabolism_Homo sapiens_hsa005620.65879175
87Arachidonic acid metabolism_Homo sapiens_hsa005900.64634766
88Melanogenesis_Homo sapiens_hsa049160.61665534
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.61009177
90Steroid biosynthesis_Homo sapiens_hsa001000.60349936
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59786476
92Nucleotide excision repair_Homo sapiens_hsa034200.58458590
93Homologous recombination_Homo sapiens_hsa034400.58294907
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57339147
95Spliceosome_Homo sapiens_hsa030400.57177514
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56555588
97Caffeine metabolism_Homo sapiens_hsa002320.56175907
98Sulfur metabolism_Homo sapiens_hsa009200.56081481
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54951700
100N-Glycan biosynthesis_Homo sapiens_hsa005100.53924518
101Fatty acid elongation_Homo sapiens_hsa000620.53848034
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53123943
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.53093012
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52481329
105Glutathione metabolism_Homo sapiens_hsa004800.52258043
106AMPK signaling pathway_Homo sapiens_hsa041520.51675537
107Prolactin signaling pathway_Homo sapiens_hsa049170.50397706
108Protein export_Homo sapiens_hsa030600.50389437
109Insulin signaling pathway_Homo sapiens_hsa049100.50159408
110mTOR signaling pathway_Homo sapiens_hsa041500.48013765
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.47899794
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47603258
113MicroRNAs in cancer_Homo sapiens_hsa052060.47382039
114MAPK signaling pathway_Homo sapiens_hsa040100.45968586
115Oxytocin signaling pathway_Homo sapiens_hsa049210.45031435
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43608369
117Phenylalanine metabolism_Homo sapiens_hsa003600.43062809
118Gap junction_Homo sapiens_hsa045400.42505910
119Ras signaling pathway_Homo sapiens_hsa040140.41504011
120Axon guidance_Homo sapiens_hsa043600.41421117
121Lysine degradation_Homo sapiens_hsa003100.40700838
122Purine metabolism_Homo sapiens_hsa002300.37849061
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37612469
124Long-term depression_Homo sapiens_hsa047300.37150511
125Propanoate metabolism_Homo sapiens_hsa006400.36927869
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36679310
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36277687
128Chemical carcinogenesis_Homo sapiens_hsa052040.36044093
129Notch signaling pathway_Homo sapiens_hsa043300.35862520
130Long-term potentiation_Homo sapiens_hsa047200.34243689
131Starch and sucrose metabolism_Homo sapiens_hsa005000.33216738
132Pancreatic secretion_Homo sapiens_hsa049720.33028195
133Dilated cardiomyopathy_Homo sapiens_hsa054140.32503249
134Rap1 signaling pathway_Homo sapiens_hsa040150.32069716
135Endometrial cancer_Homo sapiens_hsa052130.30639680
136Pancreatic cancer_Homo sapiens_hsa052120.29562674
137Sphingolipid metabolism_Homo sapiens_hsa006000.29240048
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.28415938
139Parkinsons disease_Homo sapiens_hsa050120.27280914
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27255766
141Cocaine addiction_Homo sapiens_hsa050300.26332970
142Chemokine signaling pathway_Homo sapiens_hsa040620.25252335
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24219056
144Hepatitis C_Homo sapiens_hsa051600.23372714
145Oocyte meiosis_Homo sapiens_hsa041140.22440423
146Arginine and proline metabolism_Homo sapiens_hsa003300.22295565
147Colorectal cancer_Homo sapiens_hsa052100.21149364
148Systemic lupus erythematosus_Homo sapiens_hsa053220.20901065
149Prostate cancer_Homo sapiens_hsa052150.20376348
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.19924251
151Amoebiasis_Homo sapiens_hsa051460.18910811
152Tight junction_Homo sapiens_hsa045300.18875831
153Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18012573
154Cardiac muscle contraction_Homo sapiens_hsa042600.17260661
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17112664
156Glioma_Homo sapiens_hsa052140.16031814
157Fatty acid degradation_Homo sapiens_hsa000710.15207310
158Alzheimers disease_Homo sapiens_hsa050100.14562851
159Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14486202
160Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13835575

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