GGA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of histone deacetylation (GO:0031065)4.70037229
2positive regulation of prostaglandin secretion (GO:0032308)4.48814938
3negative regulation of cell size (GO:0045792)3.91978572
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.80597318
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80597318
6regulation of prostaglandin secretion (GO:0032306)3.77367766
7apoptotic cell clearance (GO:0043277)3.70252891
8regulation of cholesterol homeostasis (GO:2000188)3.61674393
9N-acetylneuraminate metabolic process (GO:0006054)3.60343476
10maternal placenta development (GO:0001893)3.58027642
11protein localization to endosome (GO:0036010)3.50849277
12regulation of cholesterol storage (GO:0010885)3.43603489
13low-density lipoprotein particle clearance (GO:0034383)3.41230199
14positive regulation of protein deacetylation (GO:0090312)3.36689186
15positive regulation of icosanoid secretion (GO:0032305)3.33310200
16negative regulation of erythrocyte differentiation (GO:0045647)3.31150876
17regulation of somitogenesis (GO:0014807)3.30110798
18antigen processing and presentation of endogenous antigen (GO:0019883)3.23071949
19negative regulation of catenin import into nucleus (GO:0035414)3.21975732
20positive regulation of fatty acid transport (GO:2000193)3.21716941
21positive regulation of triglyceride biosynthetic process (GO:0010867)3.15560783
22NIK/NF-kappaB signaling (GO:0038061)3.15206087
23regulation of fatty acid beta-oxidation (GO:0031998)3.14326631
24stress fiber assembly (GO:0043149)3.12602044
25regulation of fatty acid transport (GO:2000191)3.11896527
26response to muramyl dipeptide (GO:0032495)3.10838325
27plasma membrane repair (GO:0001778)3.10713608
28activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.09003388
29regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07200108
30pentose-phosphate shunt (GO:0006098)3.05302410
31mannose metabolic process (GO:0006013)3.04475971
32apoptotic process involved in morphogenesis (GO:0060561)3.04425554
33regulation of gamma-delta T cell differentiation (GO:0045586)3.03559318
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.02678586
35endothelial cell chemotaxis (GO:0035767)3.01943963
36regulation of hydrogen peroxide metabolic process (GO:0010310)3.01361832
37positive regulation of CREB transcription factor activity (GO:0032793)2.99082136
38positive thymic T cell selection (GO:0045059)2.97743363
39positive regulation of nuclease activity (GO:0032075)2.97718599
40negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96868393
41negative regulation of fatty acid transport (GO:2000192)2.92580781
42cytoskeletal anchoring at plasma membrane (GO:0007016)2.92240988
43regulation of p38MAPK cascade (GO:1900744)2.90301705
44phosphatidylglycerol biosynthetic process (GO:0006655)2.89569469
45macrophage activation involved in immune response (GO:0002281)2.89071516
46lytic vacuole organization (GO:0080171)2.88962528
47lysosome organization (GO:0007040)2.88962528
48CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.86326316
49regulation of early endosome to late endosome transport (GO:2000641)2.85350995
50response to laminar fluid shear stress (GO:0034616)2.85218482
51negative regulation of heart growth (GO:0061117)2.84223859
52negative regulation of cardiac muscle tissue growth (GO:0055022)2.84223859
53negative regulation of macroautophagy (GO:0016242)2.83845147
54negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.82228520
55negative regulation of cell killing (GO:0031342)2.82228520
56cell-substrate junction assembly (GO:0007044)2.80775628
574-hydroxyproline metabolic process (GO:0019471)2.79484993
58amino sugar catabolic process (GO:0046348)2.78865684
59response to peptidoglycan (GO:0032494)2.77531066
60positive regulation of fatty acid biosynthetic process (GO:0045723)2.76467545
61negative regulation of interleukin-12 production (GO:0032695)2.75768515
62antigen processing and presentation via MHC class Ib (GO:0002475)2.74385389
63regulation of ARF GTPase activity (GO:0032312)2.73589216
64endothelial tube morphogenesis (GO:0061154)2.73287524
65morphogenesis of an endothelium (GO:0003159)2.73287524
66macroautophagy (GO:0016236)2.72750257
67positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.72014452
68negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.70587265
69receptor catabolic process (GO:0032801)2.70535874
70positive regulation of antigen processing and presentation (GO:0002579)2.69584717
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.69539131
72adherens junction assembly (GO:0034333)2.69197167
73regulation of nuclease activity (GO:0032069)2.67352904
74regulation of icosanoid secretion (GO:0032303)2.67250183
75positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.65954964
76intracellular estrogen receptor signaling pathway (GO:0030520)2.65737682
77positive regulation of p38MAPK cascade (GO:1900745)2.65486333
78epithelial cell differentiation involved in prostate gland development (GO:0060742)2.65212410
79regulation of integrin activation (GO:0033623)2.64988390
80L-alpha-amino acid transmembrane transport (GO:1902475)2.64972970
81negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64587304
82negative regulation of nucleotide catabolic process (GO:0030812)2.62151167
83epithelial cell-cell adhesion (GO:0090136)2.62106003
84regulation of gamma-delta T cell activation (GO:0046643)2.61820059
85germinal center formation (GO:0002467)2.61620010
86negative regulation of lipid transport (GO:0032369)2.60896789
87positive regulation of gamma-delta T cell activation (GO:0046645)2.60601725
88regulation of mast cell degranulation (GO:0043304)2.59927962
892-oxoglutarate metabolic process (GO:0006103)2.59201313
90peptidyl-lysine dimethylation (GO:0018027)2.57749736
91barbed-end actin filament capping (GO:0051016)2.56945234
92regulation of hippo signaling (GO:0035330)2.56762381
93regulation of leukocyte degranulation (GO:0043300)2.55814184
94regulation of NFAT protein import into nucleus (GO:0051532)2.55522797
95growth hormone receptor signaling pathway (GO:0060396)2.55506717
96regulation of translational fidelity (GO:0006450)2.55278013
97histone H4 deacetylation (GO:0070933)2.55230492
98COPI coating of Golgi vesicle (GO:0048205)2.54790819
99Golgi transport vesicle coating (GO:0048200)2.54790819
100tricarboxylic acid metabolic process (GO:0072350)2.53450125
101endoplasmic reticulum unfolded protein response (GO:0030968)2.52828349
102NADPH regeneration (GO:0006740)2.52123465
103focal adhesion assembly (GO:0048041)2.51288168
104cell-substrate adherens junction assembly (GO:0007045)2.51288168
105modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.51283741
106positive regulation by organism of defense response of other organism involved in symbiotic interact2.51283741
107modulation by symbiont of host immune response (GO:0052553)2.51283741
108positive regulation by symbiont of host defense response (GO:0052509)2.51283741
109modulation by symbiont of host defense response (GO:0052031)2.51283741
110modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51283741
111positive regulation of protein kinase C signaling (GO:0090037)2.50675128
112regulation of monocyte differentiation (GO:0045655)2.50314932
113regulation of fatty acid oxidation (GO:0046320)2.50009732
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49597668
115regulation of interferon-beta biosynthetic process (GO:0045357)2.49331633
116positive regulation of triglyceride metabolic process (GO:0090208)2.48440352
117regulation of myeloid leukocyte mediated immunity (GO:0002886)2.47664133
118defense response to protozoan (GO:0042832)2.46837896
119sexual reproduction (GO:0019953)2.46796215
120cell-cell junction maintenance (GO:0045217)2.46737184
121protein retention in ER lumen (GO:0006621)2.46466555
122amyloid precursor protein catabolic process (GO:0042987)2.46450918
123positive T cell selection (GO:0043368)2.45109440
124sodium ion export (GO:0071436)2.44509788
125T cell selection (GO:0045058)2.43799604
126histone H3 deacetylation (GO:0070932)2.43616327
127positive regulation of Rap GTPase activity (GO:0032854)2.43279435
128B cell receptor signaling pathway (GO:0050853)2.43197788
129regulation of histone deacetylation (GO:0031063)2.42865350
130lysine metabolic process (GO:0006553)2.42381654
131lysine catabolic process (GO:0006554)2.42381654
132positive regulation of lipid storage (GO:0010884)2.41735501
133heterochromatin organization (GO:0070828)2.41510126
134maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41417134
135positive regulation of fatty acid beta-oxidation (GO:0032000)2.40840894
136regulation of mast cell activation (GO:0033003)2.39339445
137cellular response to unfolded protein (GO:0034620)2.39138275
138response to protozoan (GO:0001562)2.37879422
139cellular response to exogenous dsRNA (GO:0071360)2.37702245
140activation of JUN kinase activity (GO:0007257)2.36563369
141positive regulation of lamellipodium assembly (GO:0010592)2.35678418
142negative regulation of interleukin-6 production (GO:0032715)2.35304623
143carnitine shuttle (GO:0006853)2.35224659
144negative regulation of potassium ion transmembrane transport (GO:1901380)2.34723179
145skin morphogenesis (GO:0043589)2.34713108
146semaphorin-plexin signaling pathway (GO:0071526)2.34304909
147cortical actin cytoskeleton organization (GO:0030866)2.34074890
148negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.33598408
149regulation of translational termination (GO:0006449)2.33295558
150negative regulation of tumor necrosis factor production (GO:0032720)2.33177185
151regulation of antigen processing and presentation (GO:0002577)2.32930796
152thymic T cell selection (GO:0045061)2.32281417
153regulation of mast cell activation involved in immune response (GO:0033006)2.32031963
154natural killer cell differentiation (GO:0001779)2.31883482
155tolerance induction (GO:0002507)2.31845785
156hematopoietic stem cell proliferation (GO:0071425)2.31371952
157ER-nucleus signaling pathway (GO:0006984)2.31000765
158regulation of dendritic cell antigen processing and presentation (GO:0002604)2.30307241
159fatty acid transmembrane transport (GO:1902001)2.29877753
160negative regulation of granulocyte differentiation (GO:0030853)2.27597620
161negative regulation of innate immune response (GO:0045824)2.27204642
162positive regulation of lamellipodium organization (GO:1902745)2.27082574
163negative regulation of toll-like receptor signaling pathway (GO:0034122)2.26776155
164alpha-linolenic acid metabolic process (GO:0036109)2.26764729
165immunoglobulin mediated immune response (GO:0016064)2.26502571
166negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.25697205
167negative regulation of cAMP-mediated signaling (GO:0043951)2.23253646
168regulation of endothelial cell differentiation (GO:0045601)2.21532071
169regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.20543199
170negative regulation of autophagy (GO:0010507)2.19829759
171glycosphingolipid catabolic process (GO:0046479)2.17391293
172antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.17334114
173negative regulation of myotube differentiation (GO:0010832)2.16398227
174activation of MAPKKK activity (GO:0000185)2.16259878
175regulation of defense response to virus by virus (GO:0050690)2.15053888
176regulation of regulated secretory pathway (GO:1903305)2.14767711
177negative thymic T cell selection (GO:0045060)2.14529701
178regulation of type I interferon-mediated signaling pathway (GO:0060338)2.14410469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96758343
2MYC_22102868_ChIP-Seq_BL_Human2.91966601
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.74635922
4VDR_21846776_ChIP-Seq_THP-1_Human2.65362061
5LXR_22292898_ChIP-Seq_THP-1_Human2.61977415
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.50446458
7KDM2B_26808549_Chip-Seq_DND41_Human2.43836948
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.40490725
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.34461724
10* TCF7_22412390_ChIP-Seq_EML_Mouse2.32075147
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.25202418
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.24756877
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.21750544
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11218479
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10582604
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07986351
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02801504
18* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.98861023
19RACK7_27058665_Chip-Seq_MCF-7_Human1.95281603
20ZNF263_19887448_ChIP-Seq_K562_Human1.94926218
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91779912
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.87485898
23RXR_22158963_ChIP-Seq_LIVER_Mouse1.87284223
24DROSHA_22980978_ChIP-Seq_HELA_Human1.83131488
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80683501
26MAF_26560356_Chip-Seq_TH1_Human1.75295671
27* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72977643
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71323759
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65876133
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63777057
31* UTX_26944678_Chip-Seq_JUKART_Human1.63258510
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61649148
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60915531
34KDM2B_26808549_Chip-Seq_K562_Human1.58736625
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.56472916
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.56125492
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55820654
38CLOCK_20551151_ChIP-Seq_293T_Human1.55456482
39VDR_24763502_ChIP-Seq_THP-1_Human1.54594180
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54007839
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53211165
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51401879
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50228574
44* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49289861
45P68_20966046_ChIP-Seq_HELA_Human1.48844259
46CTCF_27219007_Chip-Seq_Bcells_Human1.48228175
47E2F1_20622854_ChIP-Seq_HELA_Human1.47779234
48* ATF3_27146783_Chip-Seq_COLON_Human1.45667857
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45644072
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44887006
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44439933
52* LXR_22158963_ChIP-Seq_LIVER_Mouse1.42647146
53* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39524381
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.39177358
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37549704
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.37197658
57* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35582912
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.35051328
59CTCF_26484167_Chip-Seq_Bcells_Mouse1.33175435
60* CREB1_26743006_Chip-Seq_LNCaP_Human1.32981859
61NCOR1_26117541_ChIP-Seq_K562_Human1.32450037
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31668324
63SA1_27219007_Chip-Seq_Bcells_Human1.30847473
64SPI1_23127762_ChIP-Seq_K562_Human1.30581534
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30104192
66BCOR_27268052_Chip-Seq_Bcells_Human1.29336981
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28958176
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27811157
69* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27422459
70* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27128349
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26133313
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25762613
73* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25020919
74OCT4_19829295_ChIP-Seq_ESCs_Human1.24828289
75* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24532857
76BCL6_27268052_Chip-Seq_Bcells_Human1.24348476
77MAF_26560356_Chip-Seq_TH2_Human1.23662264
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23425957
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22977727
80GATA1_19941826_ChIP-Seq_K562_Human1.22257686
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21361331
82RARB_24833708_ChIP-Seq_LIVER_Mouse1.19782949
83CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19539220
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18865685
85SCL_19346495_ChIP-Seq_HPC-7_Human1.18221981
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18160444
87* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18154779
88* SA1_27219007_Chip-Seq_ERYTHROID_Human1.18084239
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.17972800
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17055322
91* SMC4_20622854_ChIP-Seq_HELA_Human1.17050514
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16671437
93CTCF_20526341_ChIP-Seq_ESCs_Human1.16366029
94* RUNX1_27514584_Chip-Seq_MCF-7_Human1.15385233
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.15331345
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.15212400
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14499080
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14136317
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14109132
100* ETS1_21867929_ChIP-Seq_TH2_Mouse1.13621858
101FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13401687
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13021566
103P300_27268052_Chip-Seq_Bcells_Human1.12836523
104NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12419554
105TBX20_22328084_ChIP-Seq_HEART_Mouse1.11827173
106TBX20_22080862_ChIP-Seq_HEART_Mouse1.11827173
107RARA_24833708_ChIP-Seq_LIVER_Mouse1.11720387
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11699243
109TP53_22127205_ChIP-Seq_IMR90_Human1.11336067
110* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11024523
111FOXM1_23109430_ChIP-Seq_U2OS_Human1.10767622
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10569301
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09932995
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09489260
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08865442
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06772657
117GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06042369
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05783821
119IRF8_22096565_ChIP-ChIP_GC-B_Human1.05450300
120PHF8_20622854_ChIP-Seq_HELA_Human1.05319217
121HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05162108
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04530057
123* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03640854
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03264830
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03128044
126* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02941626
127VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02650851
128* CTCF_21964334_Chip-Seq_Bcells_Human1.02609066
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02088450
130* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01241194
131* TP63_22573176_ChIP-Seq_HFKS_Human1.01206440
132IRF8_21731497_ChIP-ChIP_J774_Mouse0.98929712
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98475311
134JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97385426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.11651940
2MP0009840_abnormal_foam_cell3.08142136
3MP0003303_peritoneal_inflammation2.94877962
4MP0003300_gastrointestinal_ulcer2.66902568
5MP0009278_abnormal_bone_marrow2.44636448
6MP0008961_abnormal_basal_metabolism2.39273150
7MP0005058_abnormal_lysosome_morphology2.32349238
8MP0005076_abnormal_cell_differentiation2.30509373
9MP0010352_gastrointestinal_tract_polyps2.26116493
10MP0005451_abnormal_body_composition2.25917373
11MP0003566_abnormal_cell_adhesion2.23444959
12MP0001800_abnormal_humoral_immune2.19088354
13MP0001873_stomach_inflammation2.15910659
14MP0009764_decreased_sensitivity_to2.12052579
15MP0003191_abnormal_cellular_cholesterol2.04030601
16MP0005671_abnormal_response_to1.97716962
17MP0002452_abnormal_antigen_presenting1.94180002
18MP0002723_abnormal_immune_serum1.93202720
19MP0001835_abnormal_antigen_presentation1.91067581
20MP0005000_abnormal_immune_tolerance1.86194337
21MP0004130_abnormal_muscle_cell1.79720713
22MP0004510_myositis1.78477044
23MP0003172_abnormal_lysosome_physiology1.77985963
24MP0004185_abnormal_adipocyte_glucose1.76967452
25MP0002420_abnormal_adaptive_immunity1.74406829
26MP0001819_abnormal_immune_cell1.72803934
27MP0004381_abnormal_hair_follicle1.66556832
28MP0003436_decreased_susceptibility_to1.63679445
29MP0001502_abnormal_circadian_rhythm1.59956310
30MP0002148_abnormal_hypersensitivity_rea1.59040030
31MP0005310_abnormal_salivary_gland1.58479718
32MP0005666_abnormal_adipose_tissue1.54883470
33MP0000685_abnormal_immune_system1.54293644
34MP0005670_abnormal_white_adipose1.51014865
35MP0002254_reproductive_system_inflammat1.49735774
36MP0004858_abnormal_nervous_system1.49116226
37MP0002877_abnormal_melanocyte_morpholog1.47608494
38MP0001348_abnormal_lacrimal_gland1.45826709
39MP0008438_abnormal_cutaneous_collagen1.44766284
40MP0002933_joint_inflammation1.44061629
41MP0001958_emphysema1.43902616
42MP0001849_ear_inflammation1.43343235
43MP0005023_abnormal_wound_healing1.42215290
44MP0000751_myopathy1.41784324
45MP0004087_abnormal_muscle_fiber1.39114593
46MP0004084_abnormal_cardiac_muscle1.37170649
47MP0003283_abnormal_digestive_organ1.37071188
48MP0005375_adipose_tissue_phenotype1.35819861
49MP0005464_abnormal_platelet_physiology1.35185078
50MP0003136_yellow_coat_color1.34543853
51MP0004947_skin_inflammation1.34013918
52MP0003763_abnormal_thymus_physiology1.32226886
53MP0010630_abnormal_cardiac_muscle1.31945925
54MP0005083_abnormal_biliary_tract1.31494944
55MP0005360_urolithiasis1.31371006
56MP0000371_diluted_coat_color1.31284209
57MP0002837_dystrophic_cardiac_calcinosis1.31271397
58MP0000015_abnormal_ear_pigmentation1.30961855
59MP0000716_abnormal_immune_system1.28322817
60MP0002139_abnormal_hepatobiliary_system1.27599793
61MP0002909_abnormal_adrenal_gland1.27233451
62MP0001545_abnormal_hematopoietic_system1.27050968
63MP0005397_hematopoietic_system_phenotyp1.27050968
64MP0000750_abnormal_muscle_regeneration1.26395243
65MP0000733_abnormal_muscle_development1.24578932
66MP0002269_muscular_atrophy1.24215365
67MP0009333_abnormal_splenocyte_physiolog1.24000350
68MP0009785_altered_susceptibility_to1.23529715
69MP0001663_abnormal_digestive_system1.23118121
70MP0008469_abnormal_protein_level1.22705653
71MP0003075_altered_response_to1.19046141
72MP0003279_aneurysm1.17476232
73MP0010329_abnormal_lipoprotein_level1.15566605
74MP0000678_abnormal_parathyroid_gland1.14839259
75MP0002249_abnormal_larynx_morphology1.14266874
76MP0008260_abnormal_autophagy1.13714897
77MP0010234_abnormal_vibrissa_follicle1.13548097
78MP0003690_abnormal_glial_cell1.11717978
79MP0005330_cardiomyopathy1.11685153
80MP0002998_abnormal_bone_remodeling1.11220638
81MP0000609_abnormal_liver_physiology1.11126604
82MP0002822_catalepsy1.09922980
83MP0005167_abnormal_blood-brain_barrier1.06389896
84MP0004043_abnormal_pH_regulation1.05009773
85MP0000747_muscle_weakness1.04665222
86MP0002398_abnormal_bone_marrow1.03109331
87MP0000858_altered_metastatic_potential1.01846889
88MP0003634_abnormal_glial_cell1.01740440
89MP0002138_abnormal_hepatobiliary_system1.01635082
90MP0000003_abnormal_adipose_tissue0.99589501
91MP0003091_abnormal_cell_migration0.98406290
92MP0005275_abnormal_skin_tensile0.97847235
93MP0000343_altered_response_to0.97504017
94MP0003183_abnormal_peptide_metabolism0.97496712
95MP0000604_amyloidosis0.96019747
96MP0002429_abnormal_blood_cell0.95194609
97MP0003045_fibrosis0.94170789
98MP0005365_abnormal_bile_salt0.92574268
99MP0006082_CNS_inflammation0.92341539
100MP0003448_altered_tumor_morphology0.91576492
101MP0000759_abnormal_skeletal_muscle0.91481834
102MP0010307_abnormal_tumor_latency0.90402933
103MP0002405_respiratory_system_inflammati0.90024368
104MP0004233_abnormal_muscle_weight0.89783021
105MP0003453_abnormal_keratinocyte_physiol0.89660534
106MP0008875_abnormal_xenobiotic_pharmacok0.89623901
107MP0005319_abnormal_enzyme/_coenzyme0.89309841
108MP0001790_abnormal_immune_system0.89196516
109MP0005387_immune_system_phenotype0.89196516
110MP0001986_abnormal_taste_sensitivity0.89183948
111MP0003724_increased_susceptibility_to0.89025046
112MP0005171_absent_coat_pigmentation0.88259325
113MP0008872_abnormal_physiological_respon0.88202494
114MP0003646_muscle_fatigue0.87809544
115MP0003879_abnormal_hair_cell0.87195359
116MP0005166_decreased_susceptibility_to0.86959551
117MP0010155_abnormal_intestine_physiology0.86208810
118MP0002118_abnormal_lipid_homeostasis0.84235273
119MP0009384_cardiac_valve_regurgitation0.84040043
120MP0001533_abnormal_skeleton_physiology0.83183675
121MP0005381_digestive/alimentary_phenotyp0.82457492
122MP0009643_abnormal_urine_homeostasis0.82453479
123MP0002064_seizures0.82246689
124MP0009115_abnormal_fat_cell0.82164215
125MP0000598_abnormal_liver_morphology0.82050310
126MP0003329_amyloid_beta_deposits0.82036559
127MP0002106_abnormal_muscle_physiology0.81931290
128MP0002970_abnormal_white_adipose0.81820876
129MP0005385_cardiovascular_system_phenoty0.80297068
130MP0001544_abnormal_cardiovascular_syste0.80297068
131MP0002971_abnormal_brown_adipose0.79985999
132MP0004859_abnormal_synaptic_plasticity0.79359149
133MP0003866_abnormal_defecation0.78906644
134MP0002089_abnormal_postnatal_growth/wei0.78478121
135MP0000465_gastrointestinal_hemorrhage0.78427043
136MP0005025_abnormal_response_to0.78412933
137MP0004036_abnormal_muscle_relaxation0.78189162
138MP0004808_abnormal_hematopoietic_stem0.78140370
139MP0000249_abnormal_blood_vessel0.77927899
140MP0000266_abnormal_heart_morphology0.77359922
141MP0003828_pulmonary_edema0.77305101
142MP0000681_abnormal_thyroid_gland0.76503362
143MP0005623_abnormal_meninges_morphology0.76192031
144MP0003252_abnormal_bile_duct0.76017372
145MP0000767_abnormal_smooth_muscle0.75673800
146MP0002722_abnormal_immune_system0.75553438
147MP0002796_impaired_skin_barrier0.74866272
148MP0002234_abnormal_pharynx_morphology0.73775961
149MP0001845_abnormal_inflammatory_respons0.73713699
150MP0002060_abnormal_skin_morphology0.73092435
151MP0002653_abnormal_ependyma_morphology0.72886409
152MP0000749_muscle_degeneration0.72610724
153MP0002419_abnormal_innate_immunity0.72534055
154MP0000689_abnormal_spleen_morphology0.72506795
155MP0005377_hearing/vestibular/ear_phenot0.66592328
156MP0003878_abnormal_ear_physiology0.66592328
157MP0002075_abnormal_coat/hair_pigmentati0.66211407
158MP0002063_abnormal_learning/memory/cond0.64293321
159MP0003632_abnormal_nervous_system0.63645398

Predicted human phenotypes

RankGene SetZ-score
1Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.63305226
2Increased neuronal autofluorescent lipopigment (HP:0002074)4.48377880
3Abnormality of liposaccharide metabolism (HP:0010968)4.12428910
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.12428910
5Abnormality of glycolipid metabolism (HP:0010969)4.12428910
6Cerebral aneurysm (HP:0004944)3.91154528
7Asymmetric septal hypertrophy (HP:0001670)3.28714803
8Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.25102305
9Vacuolated lymphocytes (HP:0001922)3.15586341
10Cerebellar dysplasia (HP:0007033)3.14054008
11Type II lissencephaly (HP:0007260)3.11672272
12J-shaped sella turcica (HP:0002680)3.10227848
13Hyperacusis (HP:0010780)3.09576090
14Short femoral neck (HP:0100864)3.08442329
15Abnormality of the nasal mucosa (HP:0000433)3.03459563
16Distal upper limb amyotrophy (HP:0007149)3.01261930
17Upper limb amyotrophy (HP:0009129)3.01261930
18Nasal polyposis (HP:0100582)2.98461176
19Hemiplegia (HP:0002301)2.98384704
20Increased connective tissue (HP:0009025)2.93521169
21Polycythemia (HP:0001901)2.91758514
22Obstructive sleep apnea (HP:0002870)2.89241577
23Hand muscle atrophy (HP:0009130)2.87701639
24Oral leukoplakia (HP:0002745)2.72779440
25Back pain (HP:0003418)2.63839643
26Difficulty climbing stairs (HP:0003551)2.53843577
27Aneurysm (HP:0002617)2.53577320
28Recurrent bacterial skin infections (HP:0005406)2.53145977
29Pathologic fracture (HP:0002756)2.51560277
30Aplasia/hypoplasia of the femur (HP:0005613)2.50054836
31Urinary glycosaminoglycan excretion (HP:0003541)2.46887530
32Mucopolysacchariduria (HP:0008155)2.46887530
33Abnormality of macrophages (HP:0004311)2.46854864
34Protrusio acetabuli (HP:0003179)2.45561051
35Dysostosis multiplex (HP:0000943)2.45062483
36Stridor (HP:0010307)2.41055790
37Neurofibrillary tangles (HP:0002185)2.40249806
38Achilles tendon contracture (HP:0001771)2.36632128
39Restrictive lung disease (HP:0002091)2.36376224
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.35848512
41Upper motor neuron abnormality (HP:0002127)2.33670054
42Increased cerebral lipofuscin (HP:0011813)2.33454937
43Ulnar bowing (HP:0003031)2.33257486
44Abnormality of the Achilles tendon (HP:0005109)2.32626071
45Abnormality of polysaccharide metabolism (HP:0011012)2.29909025
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29909025
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29909025
48Difficulty running (HP:0009046)2.28938650
49Recurrent abscess formation (HP:0002722)2.28879442
50Myositis (HP:0100614)2.28359053
51Peritonitis (HP:0002586)2.27955085
52Obstructive lung disease (HP:0006536)2.27454719
53Chronic obstructive pulmonary disease (HP:0006510)2.27454719
54Recurrent fungal infections (HP:0002841)2.27110789
55Shallow orbits (HP:0000586)2.25994045
56Myoglobinuria (HP:0002913)2.25297025
57Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.24768785
58Global brain atrophy (HP:0002283)2.24120887
59Severe muscular hypotonia (HP:0006829)2.23534529
60Hypoplasia of the pons (HP:0012110)2.22966596
61Exercise-induced myalgia (HP:0003738)2.22953606
62Neuronal loss in central nervous system (HP:0002529)2.22737994
63Mediastinal lymphadenopathy (HP:0100721)2.22248908
64Ventricular tachycardia (HP:0004756)2.22205390
65Hyporeflexia of lower limbs (HP:0002600)2.20882840
66Lymphangioma (HP:0100764)2.19821029
67Long toe (HP:0010511)2.19557687
68Myocardial infarction (HP:0001658)2.18930937
69Frequent falls (HP:0002359)2.17918417
70Deep venous thrombosis (HP:0002625)2.16563536
71Interstitial pulmonary disease (HP:0006530)2.16194352
72Bundle branch block (HP:0011710)2.15758364
73Type 1 muscle fiber predominance (HP:0003803)2.14231877
74Bladder diverticulum (HP:0000015)2.12740439
75Chronic mucocutaneous candidiasis (HP:0002728)2.12497514
76Recurrent cutaneous fungal infections (HP:0011370)2.12497514
77Turricephaly (HP:0000262)2.10267984
78Gastrointestinal stroma tumor (HP:0100723)2.09508879
79Rectal prolapse (HP:0002035)2.07390785
80Right ventricular cardiomyopathy (HP:0011663)2.06865281
81Eczematoid dermatitis (HP:0000976)2.05409931
82Systemic lupus erythematosus (HP:0002725)2.05171573
83Mitral valve prolapse (HP:0001634)2.02224892
84Sudden death (HP:0001699)2.00354628
85Broad face (HP:0000283)2.00300490
86Broad distal phalanx of finger (HP:0009836)2.00100696
87Increased density of long bones (HP:0006392)1.99889833
88Exercise-induced muscle cramps (HP:0003710)1.99175750
89Macroglossia (HP:0000158)1.98501802
90Ankle contracture (HP:0006466)1.98469019
91Retinal atrophy (HP:0001105)1.98451119
92Aortic aneurysm (HP:0004942)1.98378773
93Emphysema (HP:0002097)1.98267586
94Flared iliac wings (HP:0002869)1.97207595
95Mildly elevated creatine phosphokinase (HP:0008180)1.96950296
96Hypercortisolism (HP:0001578)1.96738774
97Complement deficiency (HP:0004431)1.96698820
98Abnormality of the lower motor neuron (HP:0002366)1.95937103
99Supranuclear gaze palsy (HP:0000605)1.95665865
100Abnormality of the aortic arch (HP:0012303)1.95580007
101Clumsiness (HP:0002312)1.95044336
102Ulnar deviation of the wrist (HP:0003049)1.94427879
103Nuclear cataract (HP:0100018)1.93807180
104Abnormality of the pons (HP:0007361)1.93749923
105Annular pancreas (HP:0001734)1.92916976
106Broad metatarsal (HP:0001783)1.92160884
107Abnormality of the odontoid process (HP:0003310)1.91670462
108Colitis (HP:0002583)1.91026329
109Abnormality of complement system (HP:0005339)1.90902300
110Segmental peripheral demyelination/remyelination (HP:0003481)1.90140927
111Insomnia (HP:0100785)1.89256995
112Hemorrhage of the eye (HP:0011885)1.88609063
113Increased serum ferritin (HP:0003281)1.87971751
114Dilatation of the ascending aorta (HP:0005111)1.87522284
115Reticulocytosis (HP:0001923)1.87201752
116Loss of speech (HP:0002371)1.86395798
117Enlarged penis (HP:0000040)1.86084125
118Gingivitis (HP:0000230)1.85545803
119Orchitis (HP:0100796)1.84713218
120Muscle fiber splitting (HP:0003555)1.83744869
121Pustule (HP:0200039)1.83567235
122Increased variability in muscle fiber diameter (HP:0003557)1.83145025
123Joint stiffness (HP:0001387)1.83056479
124Xanthomatosis (HP:0000991)1.81975789
125Abnormality of the intervertebral disk (HP:0005108)1.81664330
126Gastrointestinal infarctions (HP:0005244)1.81442426
127Onion bulb formation (HP:0003383)1.81103295
128Elfin facies (HP:0004428)1.80172547
129Recurrent skin infections (HP:0001581)1.79533653
130Abnormality of the periventricular white matter (HP:0002518)1.78821014
131Stomatitis (HP:0010280)1.78089729
132Autoimmune thrombocytopenia (HP:0001973)1.78040558
133Agammaglobulinemia (HP:0004432)1.78025570
134Thoracic kyphosis (HP:0002942)1.77102272
135Deformed sella turcica (HP:0002681)1.76955613
136Abnormality of skeletal muscle fiber size (HP:0012084)1.76740859
137Rapidly progressive (HP:0003678)1.76132512
138Disproportionate tall stature (HP:0001519)1.75854747
139Increased IgE level (HP:0003212)1.75592016
140Anomalous pulmonary venous return (HP:0010772)1.74731693
141Cerebral inclusion bodies (HP:0100314)1.74697617
142Mutism (HP:0002300)1.74490487
143Polygenic inheritance (HP:0010982)1.74486590
144Diplopia (HP:0000651)1.73524390
145Abnormality of binocular vision (HP:0011514)1.73524390
146Late onset (HP:0003584)1.73397727
147Gastrointestinal inflammation (HP:0004386)1.73139391
148Premature rupture of membranes (HP:0001788)1.72253401
149Genu recurvatum (HP:0002816)1.72166057
150Meningitis (HP:0001287)1.71675391
151Gout (HP:0001997)1.71027724
152Thin bony cortex (HP:0002753)1.70908972
153Hematochezia (HP:0002573)1.70328760
154Striae distensae (HP:0001065)1.70032131
155Limb-girdle muscle atrophy (HP:0003797)1.68964329
156EMG: neuropathic changes (HP:0003445)1.67878532
157Cervical subluxation (HP:0003308)1.65285867
158Esophageal varix (HP:0002040)1.65243777
159Impaired platelet aggregation (HP:0003540)1.65037666
160Abnormal platelet function (HP:0011869)1.65037666
161Mesangial abnormality (HP:0001966)1.63838274
162Renovascular hypertension (HP:0100817)1.62172080
163Flat acetabular roof (HP:0003180)1.62063514
164Macroorchidism (HP:0000053)1.59867943
165Nephritis (HP:0000123)1.59830293
166Chest pain (HP:0100749)1.58666290
167Atrioventricular block (HP:0001678)1.58617970
168Fibroma (HP:0010614)1.58205965
169Inflammation of the large intestine (HP:0002037)1.57235156
170Cellulitis (HP:0100658)1.56618582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.43966652
2ERN13.98725873
3PKN23.70702626
4MAP3K102.96896400
5EEF2K2.81892725
6TLK12.68172366
7ICK2.67259761
8TTN2.56568832
9RIPK12.07880695
10MAP4K11.98608478
11PTK61.97618908
12IRAK31.90180680
13MAP2K71.87360682
14PRKD31.80923182
15SIK11.72409621
16TNK21.66969614
17MAP2K41.63748917
18MAP3K41.62192537
19SMG11.61519110
20EPHB11.60481981
21LRRK21.51095227
22BMX1.49727623
23TAOK11.46362549
24TYK21.42814444
25CDK121.40641052
26RIPK41.40250622
27FGFR41.39408717
28PDGFRA1.36704244
29MAP2K61.35847715
30MAP3K131.24555407
31PRPF4B1.23745944
32PAK41.23411432
33GRK61.23041227
34IRAK41.22146376
35SIK21.20293210
36ALK1.16926238
37MAP2K31.13549752
38FES1.09918938
39TGFBR21.08727833
40STK101.08506212
41TBK11.05454541
42ZAP701.05302204
43MAPK121.04092225
44RPS6KA41.03567765
45MTOR1.02639912
46MAP3K111.01546453
47TESK11.00795008
48DMPK0.98662952
49PTK20.96566136
50MAP3K140.94666710
51ZAK0.93875109
52BCKDK0.93807992
53IKBKB0.93611052
54SCYL20.93377962
55CAMK1D0.92110040
56CSK0.91630652
57CAMK1G0.90706196
58JAK10.87465348
59CHUK0.86807526
60CDK60.85078832
61SYK0.83827067
62CAMKK10.83154073
63DDR20.82947392
64DYRK1B0.82634387
65KSR20.82166879
66MAP3K70.81266581
67NEK20.81207766
68PRKD20.79475633
69TYRO30.79447878
70PRKCH0.77904653
71TESK20.76092278
72JAK20.74494517
73MAP3K10.73804454
74LMTK20.73767078
75NME20.73497469
76RET0.70836248
77ADRBK20.70306027
78IKBKE0.70243932
79STK380.70177584
80FLT30.70009999
81NEK10.68614177
82FGR0.65322012
83RPS6KA20.64924645
84MAPK110.64441450
85PAK20.64303138
86LATS20.63825356
87CDK40.63324037
88ILK0.63316265
89MATK0.63081215
90MAP3K90.62831289
91JAK30.62470102
92PKN10.61608581
93EPHA20.61218978
94MAPKAPK30.60878459
95HCK0.60158252
96WNK40.59591422
97LYN0.59329681
98ITK0.58448036
99PRKD10.57841839
100TAOK30.57356639
101RPS6KC10.56769511
102RPS6KL10.56769511
103RPS6KA10.56157891
104NTRK30.55512364
105MAP3K60.54679815
106MAP3K80.54642988
107FGFR30.53977072
108CAMKK20.53945254
109HIPK20.53758320
110PDK40.53345338
111PDK30.53345338
112RPS6KA60.53283909
113PDPK10.52844654
114MAP2K20.50110724
115PDK10.49293272
116PRKAA10.49100864
117PDGFRB0.48730800
118EPHA30.48725612
119IRAK10.48179233
120KDR0.47219538
121DAPK20.45872638
122LCK0.45668715
123PTK2B0.45219166
124MAPK150.45191672
125PHKG10.44535288
126PHKG20.44535288
127RPS6KA50.43834923
128BTK0.43830003
129PRKG20.43616630
130PRKCI0.41842262
131TAOK20.41327648
132STK110.40726724
133BLK0.40583657
134MAP3K30.40495375
135KIT0.39902074
136CDC42BPA0.39646190
137DAPK30.39615106
138CAMK40.37859431
139MARK20.37759088
140TXK0.37714066
141CSF1R0.37203985
142PRKCZ0.36885310

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.37531253
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09121142
3Intestinal immune network for IgA production_Homo sapiens_hsa046721.73612442
4Chronic myeloid leukemia_Homo sapiens_hsa052201.73109986
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70570375
6Nitrogen metabolism_Homo sapiens_hsa009101.59973740
7Acute myeloid leukemia_Homo sapiens_hsa052211.58494240
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55331793
9Insulin resistance_Homo sapiens_hsa049311.55032957
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.51512095
11Allograft rejection_Homo sapiens_hsa053301.49964558
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47933666
13Staphylococcus aureus infection_Homo sapiens_hsa051501.46273406
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44579742
15mTOR signaling pathway_Homo sapiens_hsa041501.41891405
16T cell receptor signaling pathway_Homo sapiens_hsa046601.38066493
17Arginine biosynthesis_Homo sapiens_hsa002201.37595240
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.37197637
19Asthma_Homo sapiens_hsa053101.36649702
20B cell receptor signaling pathway_Homo sapiens_hsa046621.36396523
21Autoimmune thyroid disease_Homo sapiens_hsa053201.34035379
22Lysine degradation_Homo sapiens_hsa003101.33967438
23Primary immunodeficiency_Homo sapiens_hsa053401.33783339
24Sulfur relay system_Homo sapiens_hsa041221.33067962
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.32560509
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31000245
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30909388
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30042095
29Graft-versus-host disease_Homo sapiens_hsa053321.30024962
30VEGF signaling pathway_Homo sapiens_hsa043701.29736682
31Osteoclast differentiation_Homo sapiens_hsa043801.25953478
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25133928
33Fatty acid degradation_Homo sapiens_hsa000711.23660866
34Insulin signaling pathway_Homo sapiens_hsa049101.20271442
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.20267505
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19909788
37Notch signaling pathway_Homo sapiens_hsa043301.19786698
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.16735235
39PPAR signaling pathway_Homo sapiens_hsa033201.16412870
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15525453
41GnRH signaling pathway_Homo sapiens_hsa049121.15479304
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13532665
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13211363
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12767683
45Non-small cell lung cancer_Homo sapiens_hsa052231.12505085
46Systemic lupus erythematosus_Homo sapiens_hsa053221.09461785
47* Lysosome_Homo sapiens_hsa041421.09361571
48Amoebiasis_Homo sapiens_hsa051461.09006786
49Leishmaniasis_Homo sapiens_hsa051401.08070200
50Proteoglycans in cancer_Homo sapiens_hsa052051.07018087
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06661475
52Focal adhesion_Homo sapiens_hsa045101.06483685
53Toxoplasmosis_Homo sapiens_hsa051451.05649259
54Bladder cancer_Homo sapiens_hsa052191.05386732
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.01060951
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00826043
57Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00494386
58Type II diabetes mellitus_Homo sapiens_hsa049300.99861174
59Bile secretion_Homo sapiens_hsa049760.98789767
60Endometrial cancer_Homo sapiens_hsa052130.98409258
61Carbon metabolism_Homo sapiens_hsa012000.98369740
62Glioma_Homo sapiens_hsa052140.97765175
63ABC transporters_Homo sapiens_hsa020100.97302944
64Galactose metabolism_Homo sapiens_hsa000520.96799916
65AMPK signaling pathway_Homo sapiens_hsa041520.95437500
66Caffeine metabolism_Homo sapiens_hsa002320.95390508
67Biosynthesis of amino acids_Homo sapiens_hsa012300.94479783
68Dorso-ventral axis formation_Homo sapiens_hsa043200.93190582
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.92404277
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.91994169
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90270238
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90144759
73Estrogen signaling pathway_Homo sapiens_hsa049150.89820924
74Pancreatic cancer_Homo sapiens_hsa052120.89699627
75Influenza A_Homo sapiens_hsa051640.88726686
76Rheumatoid arthritis_Homo sapiens_hsa053230.87818084
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87458706
78Hepatitis C_Homo sapiens_hsa051600.87314392
79Hepatitis B_Homo sapiens_hsa051610.86632211
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86476232
81Small cell lung cancer_Homo sapiens_hsa052220.86251753
82Prolactin signaling pathway_Homo sapiens_hsa049170.86087941
83Type I diabetes mellitus_Homo sapiens_hsa049400.85981568
84Viral myocarditis_Homo sapiens_hsa054160.85967464
85Dilated cardiomyopathy_Homo sapiens_hsa054140.85401600
86Platelet activation_Homo sapiens_hsa046110.84996790
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84555048
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84088543
89Choline metabolism in cancer_Homo sapiens_hsa052310.84086374
90Other glycan degradation_Homo sapiens_hsa005110.83748412
91Glucagon signaling pathway_Homo sapiens_hsa049220.82131492
92Fatty acid metabolism_Homo sapiens_hsa012120.82080476
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81956001
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81794192
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81427254
96Fatty acid biosynthesis_Homo sapiens_hsa000610.81046504
97Fat digestion and absorption_Homo sapiens_hsa049750.80890737
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80710942
99Adherens junction_Homo sapiens_hsa045200.79988530
100ErbB signaling pathway_Homo sapiens_hsa040120.78881730
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.76949468
102Tuberculosis_Homo sapiens_hsa051520.76847875
103Fructose and mannose metabolism_Homo sapiens_hsa000510.76161127
104Renal cell carcinoma_Homo sapiens_hsa052110.76013474
105Apoptosis_Homo sapiens_hsa042100.75771596
106HIF-1 signaling pathway_Homo sapiens_hsa040660.75638118
107Endocytosis_Homo sapiens_hsa041440.74828216
108Antigen processing and presentation_Homo sapiens_hsa046120.71914212
109Shigellosis_Homo sapiens_hsa051310.71179296
110MAPK signaling pathway_Homo sapiens_hsa040100.69807162
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68523061
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67951461
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67453354
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67414938
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67181666
116Pentose phosphate pathway_Homo sapiens_hsa000300.67055897
117Legionellosis_Homo sapiens_hsa051340.66934412
118Complement and coagulation cascades_Homo sapiens_hsa046100.66741742
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66654315
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66165015
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65538945
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64295225
123Inositol phosphate metabolism_Homo sapiens_hsa005620.63901554
124Selenocompound metabolism_Homo sapiens_hsa004500.63368289
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63272303
126Phagosome_Homo sapiens_hsa041450.62849537
127Alcoholism_Homo sapiens_hsa050340.62592916
128Viral carcinogenesis_Homo sapiens_hsa052030.61279250
129Pertussis_Homo sapiens_hsa051330.60627657
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.60189750
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60162669
132Tryptophan metabolism_Homo sapiens_hsa003800.60010758
133Chemokine signaling pathway_Homo sapiens_hsa040620.59397731
134Starch and sucrose metabolism_Homo sapiens_hsa005000.59161023
135Ovarian steroidogenesis_Homo sapiens_hsa049130.58040619
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56919327
137Herpes simplex infection_Homo sapiens_hsa051680.56592640
138Colorectal cancer_Homo sapiens_hsa052100.54982020
139Salmonella infection_Homo sapiens_hsa051320.54916259
140TNF signaling pathway_Homo sapiens_hsa046680.54913620
141Prion diseases_Homo sapiens_hsa050200.54806475
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53743940
143Cholinergic synapse_Homo sapiens_hsa047250.53272532
144Ether lipid metabolism_Homo sapiens_hsa005650.52549481
145FoxO signaling pathway_Homo sapiens_hsa040680.51067545
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.49724063
147Hematopoietic cell lineage_Homo sapiens_hsa046400.49484503
148Insulin secretion_Homo sapiens_hsa049110.48592878
149Malaria_Homo sapiens_hsa051440.46941649
150Collecting duct acid secretion_Homo sapiens_hsa049660.45937998
151Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44508692

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »