GGA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)5.97110081
2positive regulation of gamma-delta T cell activation (GO:0046645)5.59585906
3regulation of axon regeneration (GO:0048679)5.17606728
4regulation of neuron projection regeneration (GO:0070570)5.17606728
5mannose metabolic process (GO:0006013)4.86237566
6regulation of gene silencing by RNA (GO:0060966)4.78074281
7regulation of posttranscriptional gene silencing (GO:0060147)4.78074281
8regulation of gene silencing by miRNA (GO:0060964)4.78074281
9pre-miRNA processing (GO:0031054)4.40828267
10regulation of gamma-delta T cell activation (GO:0046643)4.39472279
11positive thymic T cell selection (GO:0045059)4.37935261
12regulation of gamma-delta T cell differentiation (GO:0045586)4.35114000
13I-kappaB phosphorylation (GO:0007252)4.34265010
14negative regulation of erythrocyte differentiation (GO:0045647)4.33341916
15regulation of B cell receptor signaling pathway (GO:0050855)4.25110750
16germinal center formation (GO:0002467)4.17940325
17folic acid-containing compound biosynthetic process (GO:0009396)4.16338217
18histone H3-K36 demethylation (GO:0070544)4.14015520
19nuclear pore organization (GO:0006999)4.12793485
20locomotory exploration behavior (GO:0035641)4.05321600
21paraxial mesoderm development (GO:0048339)4.03977939
22regulation of histone H3-K27 methylation (GO:0061085)4.00714882
23positive regulation of B cell differentiation (GO:0045579)3.91768797
24DNA unwinding involved in DNA replication (GO:0006268)3.90625833
25nuclear pore complex assembly (GO:0051292)3.87473317
26regulation of interferon-beta biosynthetic process (GO:0045357)3.85182180
27protein localization to kinetochore (GO:0034501)3.80763454
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.76596273
29DNA replication initiation (GO:0006270)3.73766791
30DNA replication-dependent nucleosome assembly (GO:0006335)3.73286528
31DNA replication-dependent nucleosome organization (GO:0034723)3.73286528
32antigen processing and presentation of endogenous antigen (GO:0019883)3.73120667
33regulation of transmission of nerve impulse (GO:0051969)3.72831998
34thymic T cell selection (GO:0045061)3.70439534
35B cell proliferation (GO:0042100)3.70014885
36formation of translation preinitiation complex (GO:0001731)3.68661660
37mitotic nuclear envelope disassembly (GO:0007077)3.65724921
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.63004013
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.63004013
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.63004013
41modulation by symbiont of host immune response (GO:0052553)3.63004013
42positive regulation by symbiont of host defense response (GO:0052509)3.63004013
43modulation by symbiont of host defense response (GO:0052031)3.63004013
44regulation of B cell differentiation (GO:0045577)3.62062542
45DNA strand elongation involved in DNA replication (GO:0006271)3.59435149
46negative regulation of histone methylation (GO:0031061)3.57762658
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.57503832
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.57503832
49positive T cell selection (GO:0043368)3.54428896
50NIK/NF-kappaB signaling (GO:0038061)3.53592396
51T cell selection (GO:0045058)3.50713936
52DNA strand elongation (GO:0022616)3.40826121
53nucleobase biosynthetic process (GO:0046112)3.40214800
54IMP biosynthetic process (GO:0006188)3.38513920
55nuclear envelope disassembly (GO:0051081)3.38150025
56membrane disassembly (GO:0030397)3.38150025
57immunoglobulin mediated immune response (GO:0016064)3.37557997
58maturation of SSU-rRNA (GO:0030490)3.31170015
59production of molecular mediator involved in inflammatory response (GO:0002532)3.28920735
60telomere maintenance via semi-conservative replication (GO:0032201)3.27172146
61B cell homeostasis (GO:0001782)3.26538567
62DNA replication checkpoint (GO:0000076)3.26182170
63positive regulation of SMAD protein import into nucleus (GO:0060391)3.23700028
64heterochromatin organization (GO:0070828)3.23381968
65viral transcription (GO:0019083)3.22327511
66regulation of telomere maintenance via telomerase (GO:0032210)3.22313708
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.21661984
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.20022089
69regulation of translational fidelity (GO:0006450)3.19398487
70establishment of apical/basal cell polarity (GO:0035089)3.18694772
71regulation of histone H3-K9 methylation (GO:0051570)3.18229124
72mitotic metaphase plate congression (GO:0007080)3.17926600
73DNA duplex unwinding (GO:0032508)3.17861511
74DNA geometric change (GO:0032392)3.16699304
75negative thymic T cell selection (GO:0045060)3.16130001
76macrophage activation involved in immune response (GO:0002281)3.15377528
77translational termination (GO:0006415)3.14524519
78regulation of RNA export from nucleus (GO:0046831)3.12299549
79protein localization to chromosome, centromeric region (GO:0071459)3.11332173
80positive regulation of Rap GTPase activity (GO:0032854)3.11164857
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.09554143
82regulation of hippo signaling (GO:0035330)3.08183546
83poly(A)+ mRNA export from nucleus (GO:0016973)3.06383526
84histone H3-K9 demethylation (GO:0033169)3.06292961
85negative regulation of cell killing (GO:0031342)3.05938078
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05938078
87peptidyl-arginine omega-N-methylation (GO:0035247)3.05010837
88regulation of gene silencing (GO:0060968)3.04371343
89negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03551890
90regulation of nuclear cell cycle DNA replication (GO:0033262)3.03492656
913-UTR-mediated mRNA stabilization (GO:0070935)3.01824850
92ribosomal small subunit assembly (GO:0000028)3.01135017
93histone lysine demethylation (GO:0070076)3.01060013
94histone arginine methylation (GO:0034969)2.98338307
95detection of bacterium (GO:0016045)2.96601062
96polarized epithelial cell differentiation (GO:0030859)2.94402157
97translational initiation (GO:0006413)2.93476405
98pore complex assembly (GO:0046931)2.93159081
99T cell lineage commitment (GO:0002360)2.92500695
100telomere maintenance via recombination (GO:0000722)2.90686419
101protein K6-linked ubiquitination (GO:0085020)2.89213051
102regulation of antigen processing and presentation (GO:0002577)2.88691578
103telomere maintenance via telomere lengthening (GO:0010833)2.88619794
104DNA topological change (GO:0006265)2.87675278
105regulation of SMAD protein import into nucleus (GO:0060390)2.87595698
106ribosomal large subunit biogenesis (GO:0042273)2.86954511
107mitotic sister chromatid segregation (GO:0000070)2.86703236
108negative T cell selection (GO:0043383)2.86502929
109ribosome assembly (GO:0042255)2.86428246
110purine nucleobase biosynthetic process (GO:0009113)2.85906747
111SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85594846
112positive regulation of B cell proliferation (GO:0030890)2.84789615
113mitotic recombination (GO:0006312)2.84658758
114histone H2A monoubiquitination (GO:0035518)2.84594104
115nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.84555691
116RNA stabilization (GO:0043489)2.84393350
117mRNA stabilization (GO:0048255)2.84393350
118natural killer cell differentiation (GO:0001779)2.84333572
119negative regulation of RNA splicing (GO:0033119)2.83741532
120regulation of spindle organization (GO:0090224)2.83247352
121antigen receptor-mediated signaling pathway (GO:0050851)2.83237567
122translational elongation (GO:0006414)2.82327922
123phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.82082259
124determination of adult lifespan (GO:0008340)2.81833502
125metaphase plate congression (GO:0051310)2.81541919
126histone demethylation (GO:0016577)2.80865470
127detection of other organism (GO:0098543)2.80461777
128histone H4-K12 acetylation (GO:0043983)2.80004559
129positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.79861777
130regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76653342
131protein targeting to ER (GO:0045047)2.76202461
132negative regulation of mRNA processing (GO:0050686)2.75946219
133trophectodermal cell differentiation (GO:0001829)2.74271993
134cotranslational protein targeting to membrane (GO:0006613)2.73892108
135spliceosomal tri-snRNP complex assembly (GO:0000244)2.73597101
136regulation of helicase activity (GO:0051095)2.73545705
137CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73148581
138positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72965650
139histone H3-K9 modification (GO:0061647)2.72939867
140establishment or maintenance of monopolar cell polarity (GO:0061339)2.72643273
141establishment of monopolar cell polarity (GO:0061162)2.72643273
142ribosomal small subunit biogenesis (GO:0042274)2.71566844
143negative regulation of chromosome segregation (GO:0051985)2.69929561
144regulation of mitotic spindle organization (GO:0060236)2.69846355
145regulation of DNA damage checkpoint (GO:2000001)2.69545290
146sister chromatid segregation (GO:0000819)2.69329639
147chromatin assembly (GO:0031497)2.69280110
148regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.68272477
149dosage compensation (GO:0007549)2.67388269
150histone H4 deacetylation (GO:0070933)2.67339573
151negative regulation of fibroblast apoptotic process (GO:2000270)2.66818215
152kinetochore organization (GO:0051383)2.66341989
153ribonucleoprotein complex biogenesis (GO:0022613)2.65949662
154T cell costimulation (GO:0031295)2.64992081
155ribosome biogenesis (GO:0042254)2.64904392
156establishment of protein localization to endoplasmic reticulum (GO:0072599)2.64462632
157positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64275017
158mitotic spindle assembly checkpoint (GO:0007094)2.61914401
159spindle assembly checkpoint (GO:0071173)2.61768473
160intra-S DNA damage checkpoint (GO:0031573)2.61429378
161peptidyl-arginine methylation (GO:0018216)2.60667629
162peptidyl-arginine N-methylation (GO:0035246)2.60667629
163cellular extravasation (GO:0045123)2.60560202
164kinetochore assembly (GO:0051382)2.59859181
165positive regulation of cellular amide metabolic process (GO:0034250)2.59715488
166mitotic spindle checkpoint (GO:0071174)2.59468423
167negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59306047
168negative regulation of sister chromatid segregation (GO:0033046)2.59306047
169negative regulation of mitotic sister chromatid separation (GO:2000816)2.59306047
170negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59306047
171lymphocyte costimulation (GO:0031294)2.59171837
172nucleotide-excision repair, DNA gap filling (GO:0006297)2.58652244
173negative regulation of mRNA metabolic process (GO:1903312)2.58251103
174positive regulation of B cell activation (GO:0050871)2.58045354
175regulation of Rap GTPase activity (GO:0032317)2.57972819
176positive regulation of gene expression, epigenetic (GO:0045815)2.55649433
177cellular hyperosmotic response (GO:0071474)2.54259859
178B cell mediated immunity (GO:0019724)2.53781170
179antigen processing and presentation via MHC class Ib (GO:0002475)2.53477953
180regulation of histone methylation (GO:0031060)2.53376015
181regulation of chromatin binding (GO:0035561)2.51122421
182mucosal-associated lymphoid tissue development (GO:0048537)2.51039832
183Peyers patch development (GO:0048541)2.51039832
184defense response to protozoan (GO:0042832)2.50643630
185histone H3 deacetylation (GO:0070932)2.50585515
186monoubiquitinated protein deubiquitination (GO:0035520)2.50397518
187regulation of B cell proliferation (GO:0030888)2.49234828
188modulation by virus of host process (GO:0019054)2.48969396
189regulation of nucleobase-containing compound transport (GO:0032239)2.47798794
190regulation of type I interferon-mediated signaling pathway (GO:0060338)2.47512479
191N-acetylneuraminate metabolic process (GO:0006054)2.45631584
192protein dealkylation (GO:0008214)2.44366965
193protein demethylation (GO:0006482)2.44366965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.62064468
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.24623858
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.98163077
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.58360686
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27972903
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19834190
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06030427
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91532434
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.78022674
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.74821106
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64696184
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.55736336
13TCF7_22412390_ChIP-Seq_EML_Mouse2.55161686
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.49632338
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.39701420
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.39701420
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.39701420
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37877665
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35630523
20* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.33027115
21MAF_26560356_Chip-Seq_TH1_Human2.31846140
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30643291
23VDR_24763502_ChIP-Seq_THP-1_Human2.30577190
24TP63_19390658_ChIP-ChIP_HaCaT_Human2.25808453
25MYC_22102868_ChIP-Seq_BL_Human2.20558540
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20019588
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19631702
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18099047
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.17141601
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15546348
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14531558
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.10742380
33KDM2B_26808549_Chip-Seq_DND41_Human2.09307146
34XRN2_22483619_ChIP-Seq_HELA_Human2.04024205
35LXR_22292898_ChIP-Seq_THP-1_Human2.03548614
36ETS1_20019798_ChIP-Seq_JURKAT_Human2.03454593
37* UTX_26944678_Chip-Seq_JUKART_Human2.02664329
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99985119
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99255419
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98386778
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94858926
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94121511
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.93858925
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.91454924
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89131655
46MAF_26560356_Chip-Seq_TH2_Human1.88644912
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85649619
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85441010
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83943629
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83295304
51MYB_26560356_Chip-Seq_TH1_Human1.82499729
52CIITA_25753668_ChIP-Seq_RAJI_Human1.82356837
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81629603
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.80406782
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79244281
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77737000
57SCL_19346495_ChIP-Seq_HPC-7_Human1.77041251
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75895205
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75749921
60* MYB_26560356_Chip-Seq_TH2_Human1.72242280
61TTF2_22483619_ChIP-Seq_HELA_Human1.69694200
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66504882
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.66331030
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64123046
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63855114
66TFEB_21752829_ChIP-Seq_HELA_Human1.62101778
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59574196
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59442491
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.59233453
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.57436855
71SPI1_23127762_ChIP-Seq_K562_Human1.57087149
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54388572
73SPI1_23547873_ChIP-Seq_NB4_Human1.54126398
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53928213
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.52997817
76VDR_23849224_ChIP-Seq_CD4+_Human1.52169877
77FOXP3_21729870_ChIP-Seq_TREG_Human1.51906983
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51854536
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49867287
80AR_21909140_ChIP-Seq_LNCAP_Human1.49787054
81* NCOR1_26117541_ChIP-Seq_K562_Human1.48733895
82DCP1A_22483619_ChIP-Seq_HELA_Human1.48315748
83* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47202721
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45785472
85GABP_19822575_ChIP-Seq_HepG2_Human1.45654898
86* KDM2B_26808549_Chip-Seq_JURKAT_Human1.44189254
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43262152
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42249806
89* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42112641
90KDM5A_27292631_Chip-Seq_BREAST_Human1.41437676
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39410081
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38050506
93IRF8_21731497_ChIP-ChIP_J774_Mouse1.36607859
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36424885
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35273433
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.33972632
97* NANOG_21062744_ChIP-ChIP_HESCs_Human1.32956507
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32525285
99ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32520961
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.32421048
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32313784
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31634064
103VDR_21846776_ChIP-Seq_THP-1_Human1.31327742
104* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30957094
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30153674
106TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29806502
107GATA1_19941827_ChIP-Seq_MEL_Mouse1.29239910
108* RUNX_20019798_ChIP-Seq_JUKART_Human1.27427686
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27152918
110KDM2B_26808549_Chip-Seq_K562_Human1.27114207
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26887247
112NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26208421
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24901287
114GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24700014
115* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24506538
116STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22695573
117STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22152852
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20733877
119* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20648921
120RACK7_27058665_Chip-Seq_MCF-7_Human1.20142412
121* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19551867
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17629743
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16747520
124ELK1_19687146_ChIP-ChIP_HELA_Human1.15773224
125* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15159795
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15063043
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14826390
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13722028
129PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13076453
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12952900
131CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12533139
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11706499
133SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10734017
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08397492
135NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08194832
136* ELF1_20517297_ChIP-Seq_JURKAT_Human1.07870503
137PU_27001747_Chip-Seq_BMDM_Mouse1.07564397
138BP1_19119308_ChIP-ChIP_Hs578T_Human1.06683117
139NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06254323
140MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04998404
141SMC4_20622854_ChIP-Seq_HELA_Human1.04957024
142* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04172464
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02747377
144FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02519002
145ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02256478
146NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02155804
147EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02016973
148ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00607653
149NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99506347
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98270617
151POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97589410
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96939234
153NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96851232
154PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96768665
155* P68_20966046_ChIP-Seq_HELA_Human0.96115014
156OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95549759
157PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95383057
158CREB1_26743006_Chip-Seq_LNCaP_Human0.94532497
159* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93883850
160BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93788809
161CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93745327
162GATA1_19941826_ChIP-Seq_K562_Human0.93701794
163GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93404307
164HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93060543
165* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92625144
166SA1_27219007_Chip-Seq_ERYTHROID_Human0.92480179
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91977189
168FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91919307
169* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90482199
170GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89389751
171RUNX1_27514584_Chip-Seq_MCF-7_Human0.88941636
172* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88464642
173CHD1_26751641_Chip-Seq_LNCaP_Human0.88285620
174CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88207497
175FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88019478
176SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.87364811
177* BCOR_27268052_Chip-Seq_Bcells_Human0.86206949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog4.24297437
2MP0003693_abnormal_embryo_hatching3.71137076
3MP0003111_abnormal_nucleus_morphology3.45764177
4MP0001835_abnormal_antigen_presentation3.29825139
5MP0004957_abnormal_blastocyst_morpholog3.24876399
6MP0010094_abnormal_chromosome_stability3.16016078
7MP0001800_abnormal_humoral_immune3.13891893
8MP0005387_immune_system_phenotype3.12763194
9MP0001790_abnormal_immune_system3.12763194
10MP0000685_abnormal_immune_system3.07670528
11MP0002009_preneoplasia3.04729679
12MP0008057_abnormal_DNA_replication2.92617375
13MP0003077_abnormal_cell_cycle2.90642511
14MP0003172_abnormal_lysosome_physiology2.84857208
15MP0003763_abnormal_thymus_physiology2.78311030
16MP0003123_paternal_imprinting2.68037764
17MP0005058_abnormal_lysosome_morphology2.67182069
18MP0005451_abnormal_body_composition2.50680680
19MP0003303_peritoneal_inflammation2.33554472
20MP0010030_abnormal_orbit_morphology2.33401733
21MP0002452_abnormal_antigen_presenting2.31147984
22MP0005000_abnormal_immune_tolerance2.22941074
23MP0003436_decreased_susceptibility_to2.22879052
24MP0005671_abnormal_response_to2.22016954
25MP0002398_abnormal_bone_marrow2.20356476
26MP0002723_abnormal_immune_serum2.18201754
27MP0002420_abnormal_adaptive_immunity2.16068327
28MP0003283_abnormal_digestive_organ2.14780184
29MP0008058_abnormal_DNA_repair2.13035770
30MP0001819_abnormal_immune_cell2.08293138
31MP0003941_abnormal_skin_development2.07522988
32MP0010352_gastrointestinal_tract_polyps2.03992656
33MP0003121_genomic_imprinting2.02105522
34MP0000689_abnormal_spleen_morphology2.00397567
35MP0008932_abnormal_embryonic_tissue1.99258528
36MP0000716_abnormal_immune_system1.94447114
37MP0001730_embryonic_growth_arrest1.93748900
38MP0000350_abnormal_cell_proliferation1.89087415
39MP0005076_abnormal_cell_differentiation1.86493735
40MP0003119_abnormal_digestive_system1.86007121
41MP0009278_abnormal_bone_marrow1.85448243
42MP0003890_abnormal_embryonic-extraembry1.85091715
43MP0001672_abnormal_embryogenesis/_devel1.84782027
44MP0005380_embryogenesis_phenotype1.84782027
45MP0003567_abnormal_fetal_cardiomyocyte1.80276070
46MP0003122_maternal_imprinting1.79080965
47MP0004197_abnormal_fetal_growth/weight/1.77059676
48MP0004264_abnormal_extraembryonic_tissu1.76985519
49MP0000703_abnormal_thymus_morphology1.75243827
50MP0002084_abnormal_developmental_patter1.74992581
51MP0008007_abnormal_cellular_replicative1.73208459
52MP0002085_abnormal_embryonic_tissue1.72464158
53MP0002722_abnormal_immune_system1.72460735
54MP0002405_respiratory_system_inflammati1.70708923
55MP0001697_abnormal_embryo_size1.67273392
56MP0003984_embryonic_growth_retardation1.66560151
57MP0002429_abnormal_blood_cell1.65531941
58MP0002088_abnormal_embryonic_growth/wei1.65339401
59MP0002419_abnormal_innate_immunity1.64546539
60MP0002166_altered_tumor_susceptibility1.63275225
61MP0005025_abnormal_response_to1.61407567
62MP0002086_abnormal_extraembryonic_tissu1.56580570
63MP0002877_abnormal_melanocyte_morpholog1.55018314
64MP0002080_prenatal_lethality1.48622050
65MP0008260_abnormal_autophagy1.48579016
66MP0004133_heterotaxia1.45265248
67MP0001873_stomach_inflammation1.44863791
68MP0009333_abnormal_splenocyte_physiolog1.42948772
69MP0000537_abnormal_urethra_morphology1.42766276
70MP0003566_abnormal_cell_adhesion1.42718604
71MP0001293_anophthalmia1.40397707
72MP0005310_abnormal_salivary_gland1.39881803
73MP0009672_abnormal_birth_weight1.39473749
74MP0000490_abnormal_crypts_of1.29729200
75MP0009053_abnormal_anal_canal1.29149028
76MP0000428_abnormal_craniofacial_morphol1.28436025
77MP0003705_abnormal_hypodermis_morpholog1.26512326
78MP0010307_abnormal_tumor_latency1.25745757
79MP0006292_abnormal_olfactory_placode1.24406033
80MP0003937_abnormal_limbs/digits/tail_de1.22608075
81MP0003786_premature_aging1.21978653
82MP0004381_abnormal_hair_follicle1.21049363
83MP0009703_decreased_birth_body1.20894623
84MP0005075_abnormal_melanosome_morpholog1.20733086
85MP0005408_hypopigmentation1.20456364
86MP0009840_abnormal_foam_cell1.19212854
87MP0000678_abnormal_parathyroid_gland1.17671686
88MP0005257_abnormal_intraocular_pressure1.17106311
89MP0002111_abnormal_tail_morphology1.14484602
90MP0002396_abnormal_hematopoietic_system1.10435611
91MP0010155_abnormal_intestine_physiology1.10046250
92MP0002653_abnormal_ependyma_morphology1.09594961
93MP0009115_abnormal_fat_cell1.07992015
94MP0003300_gastrointestinal_ulcer1.06886877
95MP0004272_abnormal_basement_membrane1.03850061
96MP0000313_abnormal_cell_death1.02039635
97MP0003385_abnormal_body_wall1.01879703
98MP0002697_abnormal_eye_size1.01390428
99MP0006054_spinal_hemorrhage1.01248684
100MP0004185_abnormal_adipocyte_glucose1.00550220
101MP0003935_abnormal_craniofacial_develop0.99810201
102MP0000613_abnormal_salivary_gland0.99800821
103MP0001845_abnormal_inflammatory_respons0.99090781
104MP0001853_heart_inflammation0.98395923
105MP0000516_abnormal_urinary_system0.97770817
106MP0005367_renal/urinary_system_phenotyp0.97770817
107MP0003828_pulmonary_edema0.96237899
108MP0002938_white_spotting0.95483449
109MP0005464_abnormal_platelet_physiology0.95024134
110MP0000432_abnormal_head_morphology0.94672960
111MP0005220_abnormal_exocrine_pancreas0.93565144
112MP0000049_abnormal_middle_ear0.92997398
113MP0008995_early_reproductive_senescence0.91567431
114MP0002138_abnormal_hepatobiliary_system0.91544043
115MP0003315_abnormal_perineum_morphology0.91168860
116MP0002254_reproductive_system_inflammat0.90446877
117MP0003183_abnormal_peptide_metabolism0.89497418
118MP0008877_abnormal_DNA_methylation0.89417919
119MP0001286_abnormal_eye_development0.88582913
120MP0003091_abnormal_cell_migration0.84822694
121MP0000733_abnormal_muscle_development0.84681686
122MP0004233_abnormal_muscle_weight0.84656298
123MP0002019_abnormal_tumor_incidence0.84446451
124MP0002249_abnormal_larynx_morphology0.83403498
125MP0010234_abnormal_vibrissa_follicle0.83089576
126MP0000858_altered_metastatic_potential0.82022663
127MP0003755_abnormal_palate_morphology0.80585494
128MP0001545_abnormal_hematopoietic_system0.80512264
129MP0005397_hematopoietic_system_phenotyp0.80512264
130MP0002132_abnormal_respiratory_system0.80498212
131MP0002127_abnormal_cardiovascular_syste0.80028913
132MP0003942_abnormal_urinary_system0.79475515
133MP0002998_abnormal_bone_remodeling0.79212740
134MP0000371_diluted_coat_color0.78722849
135MP0004947_skin_inflammation0.78341073
136MP0002092_abnormal_eye_morphology0.78335167
137MP0000015_abnormal_ear_pigmentation0.77878234
138MP0002116_abnormal_craniofacial_bone0.76023512
139MP0002925_abnormal_cardiovascular_devel0.75772663
140MP0002114_abnormal_axial_skeleton0.75490917
141MP0005623_abnormal_meninges_morphology0.74959835
142MP0005621_abnormal_cell_physiology0.74510899
143MP0002089_abnormal_postnatal_growth/wei0.74298150
144MP0005508_abnormal_skeleton_morphology0.74243718
145MP0005384_cellular_phenotype0.73267944
146MP0001986_abnormal_taste_sensitivity0.73120392
147MP0002148_abnormal_hypersensitivity_rea0.72372019
148MP0002932_abnormal_joint_morphology0.71552298
149MP0001849_ear_inflammation0.70655746
150MP0002933_joint_inflammation0.70019258
151MP0002075_abnormal_coat/hair_pigmentati0.69896122
152MP0003632_abnormal_nervous_system0.69790615
153MP0000266_abnormal_heart_morphology0.69605895
154MP0000920_abnormal_myelination0.69505230
155MP0002006_tumorigenesis0.67877455
156MP0003453_abnormal_keratinocyte_physiol0.67611162
157MP0001348_abnormal_lacrimal_gland0.67094718
158MP0004808_abnormal_hematopoietic_stem0.65987087
159MP0002693_abnormal_pancreas_physiology0.65923435
160MP0003115_abnormal_respiratory_system0.65791419
161MP0008438_abnormal_cutaneous_collagen0.65660452
162MP0001915_intracranial_hemorrhage0.65253761
163MP0008469_abnormal_protein_level0.64850854
164MP0003656_abnormal_erythrocyte_physiolo0.64592296
165MP0001186_pigmentation_phenotype0.64035231
166MP0010630_abnormal_cardiac_muscle0.63823414
167MP0000609_abnormal_liver_physiology0.61311758

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.58685012
2Gastrointestinal stroma tumor (HP:0100723)5.56066953
3Agammaglobulinemia (HP:0004432)5.48152139
4Colitis (HP:0002583)4.17796562
5Abnormality of the sella turcica (HP:0002679)4.10491549
6Ependymoma (HP:0002888)3.88986027
7Reticulocytopenia (HP:0001896)3.88563122
8Viral hepatitis (HP:0006562)3.83091635
9Recurrent sinusitis (HP:0011108)3.68869154
10Cellulitis (HP:0100658)3.68333409
11Meningitis (HP:0001287)3.52477264
12Abnormality of the fingertips (HP:0001211)3.42764128
13Lymphopenia (HP:0001888)3.39517088
14Recurrent viral infections (HP:0004429)3.39276168
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37179234
16Chromsome breakage (HP:0040012)3.29886812
17Eczematoid dermatitis (HP:0000976)3.27731754
18Abnormality of cells of the lymphoid lineage (HP:0012140)3.17557917
19Gastrointestinal inflammation (HP:0004386)3.15797486
20Abnormality of the septum pellucidum (HP:0007375)3.15241159
21Panhypogammaglobulinemia (HP:0003139)3.13310523
22Restrictive lung disease (HP:0002091)3.12395601
23Papilloma (HP:0012740)3.07303418
24Verrucae (HP:0200043)3.07303418
25Emphysema (HP:0002097)3.02052986
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.01128306
27Mediastinal lymphadenopathy (HP:0100721)3.00442011
28Recurrent bacterial skin infections (HP:0005406)3.00128319
29Selective tooth agenesis (HP:0001592)2.99248790
30Inflammation of the large intestine (HP:0002037)2.98641043
31Medulloblastoma (HP:0002885)2.98614751
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.93435848
33Osteomyelitis (HP:0002754)2.89133688
34Colon cancer (HP:0003003)2.82950059
35Breast hypoplasia (HP:0003187)2.78506064
36Subacute progressive viral hepatitis (HP:0006572)2.76458443
37Abnormality of macrophages (HP:0004311)2.76039220
38Absent radius (HP:0003974)2.75347932
39Vasculitis (HP:0002633)2.74955534
40Birth length less than 3rd percentile (HP:0003561)2.71509465
41Patellar aplasia (HP:0006443)2.68663936
42Recurrent abscess formation (HP:0002722)2.67297618
43Missing ribs (HP:0000921)2.63354392
44Absent thumb (HP:0009777)2.60338536
45Aplasia/Hypoplasia of the patella (HP:0006498)2.59683662
46Absent septum pellucidum (HP:0001331)2.55191894
47Germ cell neoplasia (HP:0100728)2.55008012
48Chronic mucocutaneous candidiasis (HP:0002728)2.53345334
49Recurrent cutaneous fungal infections (HP:0011370)2.53345334
50Renal duplication (HP:0000075)2.53244722
51Astrocytoma (HP:0009592)2.53197452
52Abnormality of the astrocytes (HP:0100707)2.53197452
53Absent forearm bone (HP:0003953)2.52895764
54Aplasia involving forearm bones (HP:0009822)2.52895764
55Increased cerebral lipofuscin (HP:0011813)2.49340463
56Recurrent bronchitis (HP:0002837)2.44764876
57Rhabdomyosarcoma (HP:0002859)2.44504140
58Recurrent otitis media (HP:0000403)2.43480646
59Abnormal number of incisors (HP:0011064)2.43301936
60Obstructive lung disease (HP:0006536)2.41754141
61Chronic obstructive pulmonary disease (HP:0006510)2.41754141
62Duplicated collecting system (HP:0000081)2.40744732
63Meckel diverticulum (HP:0002245)2.38893022
64Rib fusion (HP:0000902)2.38292454
65Deep palmar crease (HP:0006191)2.37280681
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.31800770
67Neoplasm of striated muscle (HP:0009728)2.31293305
68Thoracic kyphosis (HP:0002942)2.29622917
69Abnormality of the ileum (HP:0001549)2.27585637
70Recurrent fungal infections (HP:0002841)2.25987411
71Aplasia/hypoplasia of the humerus (HP:0006507)2.23982124
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.23669502
73Recurrent pneumonia (HP:0006532)2.23656425
74IgA deficiency (HP:0002720)2.22676726
75Glioma (HP:0009733)2.20582741
76Trismus (HP:0000211)2.19777664
77Heterotopia (HP:0002282)2.19606025
78Recurrent gram-negative bacterial infections (HP:0005420)2.19414849
79Ectopic kidney (HP:0000086)2.18959980
80Shawl scrotum (HP:0000049)2.18902334
81Metaphyseal cupping (HP:0003021)2.18676325
82Hepatitis (HP:0012115)2.18172808
83Recurrent skin infections (HP:0001581)2.16695865
84Neonatal hypoglycemia (HP:0001998)2.16077105
85Spontaneous hematomas (HP:0007420)2.15971671
86Hypoplasia of the thymus (HP:0000778)2.15596616
87Progressive external ophthalmoplegia (HP:0000590)2.13906111
88Carpal bone hypoplasia (HP:0001498)2.13345994
89Recurrent lower respiratory tract infections (HP:0002783)2.08862042
90Short humerus (HP:0005792)2.07338149
91Neoplasm of the oral cavity (HP:0100649)2.05872434
92Lymphoma (HP:0002665)2.05831397
93Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04739270
94Vitreoretinal degeneration (HP:0000655)2.03178718
95Abnormality of the thoracic spine (HP:0100711)2.02594118
96Abnormality of cells of the erythroid lineage (HP:0012130)2.02238614
97Neoplasm of the pancreas (HP:0002894)2.02107614
98Atresia of the external auditory canal (HP:0000413)2.01503060
99Nephroblastoma (Wilms tumor) (HP:0002667)2.00723591
100Proximal placement of thumb (HP:0009623)1.99878278
101Deviation of the thumb (HP:0009603)1.99420314
102Abnormality of chromosome stability (HP:0003220)1.99198077
103Sepsis (HP:0100806)1.97939895
104Abnormality of small intestinal villus morphology (HP:0011472)1.97454914
105Villous atrophy (HP:0011473)1.97454914
106Hyperinsulinemic hypoglycemia (HP:0000825)1.96279309
107Anal stenosis (HP:0002025)1.95493232
108Abnormality of the renal collecting system (HP:0004742)1.94552389
109Abnormality of the labia minora (HP:0012880)1.94469712
110Agnosia (HP:0010524)1.91645600
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91451132
112Short 4th metacarpal (HP:0010044)1.91451132
113Abnormality of the preputium (HP:0100587)1.90449620
114Embryonal renal neoplasm (HP:0011794)1.89708359
115Primary adrenal insufficiency (HP:0008207)1.89614208
116High anterior hairline (HP:0009890)1.89348224
117Microvesicular hepatic steatosis (HP:0001414)1.88948915
118Abnormality of the lumbar spine (HP:0100712)1.88626874
11911 pairs of ribs (HP:0000878)1.88614729
120Overlapping toe (HP:0001845)1.87418090
121Increased nuchal translucency (HP:0010880)1.87248975
122Tracheoesophageal fistula (HP:0002575)1.87089032
123Impulsivity (HP:0100710)1.86190519
124Abnormal pancreas size (HP:0012094)1.86184721
125Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86075092
126Gastrointestinal carcinoma (HP:0002672)1.85614618
127Malignant gastrointestinal tract tumors (HP:0006749)1.85614618
128Leiomyosarcoma (HP:0100243)1.84957189
129Uterine leiomyosarcoma (HP:0002891)1.84957189
130IgM deficiency (HP:0002850)1.84226255
131Supernumerary spleens (HP:0009799)1.83135538
132Abnormal number of erythroid precursors (HP:0012131)1.83128702
133Slender long bone (HP:0003100)1.82606464
134Abnormality of DNA repair (HP:0003254)1.82527605
135Broad thumb (HP:0011304)1.81816192
136Leukopenia (HP:0001882)1.81447118
137Optic nerve hypoplasia (HP:0000609)1.81395166
138Multiple enchondromatosis (HP:0005701)1.79551006
139Small intestinal stenosis (HP:0012848)1.79418983
140Duodenal stenosis (HP:0100867)1.79418983
141Short thumb (HP:0009778)1.79264122
142High pitched voice (HP:0001620)1.78018642
143Squamous cell carcinoma (HP:0002860)1.78005021
144Flat acetabular roof (HP:0003180)1.77496910
145Abnormality of the carotid arteries (HP:0005344)1.77407726
146Myelodysplasia (HP:0002863)1.77286567
147Aplasia/Hypoplasia of the thymus (HP:0010515)1.77076603
148Increased IgE level (HP:0003212)1.76286485
149Short 5th finger (HP:0009237)1.76276748
150Chronic diarrhea (HP:0002028)1.76173614
151Thickened helices (HP:0000391)1.74648418
152Rough bone trabeculation (HP:0100670)1.74640346
153Macrocytic anemia (HP:0001972)1.74536513
154Abnormality of the calcaneus (HP:0008364)1.74396825
155Hypertensive crisis (HP:0100735)1.74191728
156Short middle phalanx of the 5th finger (HP:0004220)1.73810802
157Pallor (HP:0000980)1.73272026
158Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73028959
159Supernumerary ribs (HP:0005815)1.72236520
160Supernumerary bones of the axial skeleton (HP:0009144)1.72003911
161Encephalitis (HP:0002383)1.71920644
162Ureteral duplication (HP:0000073)1.71397983
163Basal cell carcinoma (HP:0002671)1.69906247
164Osteomalacia (HP:0002749)1.69656337
165Unilateral renal agenesis (HP:0000122)1.69379098
166Seborrheic dermatitis (HP:0001051)1.69377992
167Hyperacusis (HP:0010780)1.69130938
168Transitional cell carcinoma of the bladder (HP:0006740)1.69043614
169Broad palm (HP:0001169)1.68447014
170Degeneration of anterior horn cells (HP:0002398)1.68077854
171Abnormality of the anterior horn cell (HP:0006802)1.68077854
172Cafe-au-lait spot (HP:0000957)1.67797449
173Abnormality of abdominal situs (HP:0011620)1.67222655
174Abdominal situs inversus (HP:0003363)1.67222655
175Angiofibromas (HP:0010615)1.66637209
176Adenoma sebaceum (HP:0009720)1.66637209
177Gastrointestinal infarctions (HP:0005244)1.66190468
178Cutis marmorata (HP:0000965)1.66162114
179Hypoplastic labia majora (HP:0000059)1.66101550
180Triphalangeal thumb (HP:0001199)1.64518817
181Abnormality of reticulocytes (HP:0004312)1.64335576
182Primary amenorrhea (HP:0000786)1.63946373
183Visceral angiomatosis (HP:0100761)1.63016926
184Chest pain (HP:0100749)1.62962255
185Hemorrhage of the eye (HP:0011885)1.61699985
186Aplasia/Hypoplasia of the sternum (HP:0006714)1.61245342
187Teleangiectasia of the skin (HP:0100585)1.61165998
188Stomach cancer (HP:0012126)1.61057948
189Upper limb muscle weakness (HP:0003484)1.61022180
190Abnormality of the prostate (HP:0008775)1.60961951
191Growth hormone deficiency (HP:0000824)1.60689091
192Hepatoblastoma (HP:0002884)1.60201001
193Abnormality of the duodenum (HP:0002246)1.59974748
194Horseshoe kidney (HP:0000085)1.59860877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.47180499
2WEE13.06690228
3BUB12.95647982
4PASK2.93849055
5RIPK42.87877347
6MAP3K132.79243867
7CDC72.74762935
8PRPF4B2.63693681
9SMG12.49989955
10MAP3K102.42003223
11NEK22.40967017
12TTK2.39924274
13TLK12.25805052
14RPS6KB22.09777032
15EPHA22.08895169
16CASK2.02172154
17FGFR41.98696923
18EEF2K1.94713842
19CDK71.90292787
20BRD41.88261292
21SRPK11.85675154
22FLT31.81459141
23PLK41.81042509
24PKN21.77575056
25TYK21.73289267
26SCYL21.69955497
27CAMK1D1.68384106
28MAP3K141.67286145
29NEK11.57687762
30SIK21.57272367
31TRIB31.54202875
32CAMK1G1.53744773
33PLK11.53444591
34MKNK21.53166508
35CDK41.52964237
36AKT31.46629307
37LATS11.45661184
38IRAK41.45437464
39TSSK61.42509437
40ATR1.40589675
41CHEK21.40012833
42CSF1R1.39974618
43SYK1.37743318
44FGFR31.32142205
45ALK1.30753355
46MKNK11.28766453
47CHEK11.25933188
48MAP3K81.25464444
49AURKB1.25299256
50MAP3K71.24848095
51BRSK21.23362422
52PRKCI1.23258561
53PDGFRA1.21383981
54ZAK1.16357436
55DYRK31.15995578
56BLK1.15954729
57MTOR1.15377963
58STK38L1.11832563
59LYN1.11001014
60SIK11.09497362
61STK41.07732485
62KSR21.07106580
63STK101.07008480
64INSRR1.06523782
65EIF2AK11.00849843
66PIM10.98043837
67NME20.97607545
68LATS20.96398962
69LRRK20.96017532
70EIF2AK30.94835339
71MARK20.92847428
72CDC42BPA0.92825931
73AURKA0.91629570
74ATM0.91385302
75ITK0.90446680
76RPS6KA40.89863945
77ERBB40.89417090
78ACVR1B0.89025623
79CDK20.88858936
80TGFBR10.88602853
81MAPK120.88264590
82CDK60.87326473
83PLK30.87267293
84ICK0.86413810
85STK160.86162007
86IRAK30.85637752
87MAP2K30.85423902
88MAPK110.84101708
89PAK40.83370462
90JAK30.82975203
91MAP2K20.81827241
92HCK0.81628402
93HIPK20.79839435
94ERN10.79657427
95STK30.78564281
96IKBKE0.77102020
97PDK10.76800071
98TYRO30.75370664
99PDPK10.75279882
100PTK60.74840241
101VRK10.74698347
102CSK0.74361306
103AKT20.74023870
104FES0.69350846
105PAK20.67275179
106TBK10.66820805
107MARK30.64489331
108MAPKAPK30.64411832
109MAPK70.63347584
110MET0.63295577
111LCK0.62303232
112CDK90.62261406
113FGR0.61620889
114SGK30.61556198
115MELK0.60804743
116JAK10.60547766
117CSNK2A20.60468717
118PNCK0.59138643
119CDK10.59122060
120TEC0.58922453
121RET0.57065380
122MAP3K10.55959313
123AKT10.55628906
124JAK20.52860615
125PRKDC0.52682773
126BCKDK0.52389693
127CSNK1E0.50376262
128DDR20.50180534
129BRAF0.49721229
130WNK10.49568410
131NLK0.48770496
132ZAP700.48518904
133TNK20.48510873
134DMPK0.47642013
135SGK20.47551758
136TTN0.46828992
137SIK30.46663077
138PRKCQ0.45921414
139CSNK2A10.45579268
140BMX0.44282085
141MAP3K90.44007376
142MATK0.43045795
143RPS6KC10.42757738
144RPS6KL10.42757738
145MAPK100.42612787
146GRK60.42031530
147CHUK0.40554922
148BTK0.40423999
149BRSK10.39943398
150MAPK140.38416105
151CSNK1D0.38236004
152IKBKB0.37848022
153MAP4K10.37758085
154PAK10.37532771
155YES10.37523732
156RAF10.37325138
157FGFR20.37111088
158PRKD20.36974117
159CDK30.36862458
160MAP3K30.36514507
161DYRK1B0.36412539
162MAPK30.34644163

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.02076251
2Mismatch repair_Homo sapiens_hsa034303.85546144
3Spliceosome_Homo sapiens_hsa030402.92683653
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90172561
5RNA transport_Homo sapiens_hsa030132.88159343
6Base excision repair_Homo sapiens_hsa034102.87559330
7One carbon pool by folate_Homo sapiens_hsa006702.87142401
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.82300416
9Ribosome_Homo sapiens_hsa030102.73398783
10Homologous recombination_Homo sapiens_hsa034402.57890403
11Nucleotide excision repair_Homo sapiens_hsa034202.52345906
12Cell cycle_Homo sapiens_hsa041102.48869553
13Allograft rejection_Homo sapiens_hsa053302.45684303
14Autoimmune thyroid disease_Homo sapiens_hsa053202.43529496
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.35853406
16Asthma_Homo sapiens_hsa053102.32614671
17Graft-versus-host disease_Homo sapiens_hsa053322.24790717
18Fanconi anemia pathway_Homo sapiens_hsa034602.18824239
19RNA polymerase_Homo sapiens_hsa030202.17563866
20Staphylococcus aureus infection_Homo sapiens_hsa051502.13199882
21Leishmaniasis_Homo sapiens_hsa051402.03156719
22Type I diabetes mellitus_Homo sapiens_hsa049401.99954650
23mRNA surveillance pathway_Homo sapiens_hsa030151.95354749
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.83888534
25Pyrimidine metabolism_Homo sapiens_hsa002401.67864076
26Non-homologous end-joining_Homo sapiens_hsa034501.60756553
27Osteoclast differentiation_Homo sapiens_hsa043801.59308278
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.58022896
29p53 signaling pathway_Homo sapiens_hsa041151.55186510
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54893320
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48870689
32Influenza A_Homo sapiens_hsa051641.48239689
33T cell receptor signaling pathway_Homo sapiens_hsa046601.45066639
34Proteasome_Homo sapiens_hsa030501.44114555
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42516941
36RNA degradation_Homo sapiens_hsa030181.42507649
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41030844
38Basal transcription factors_Homo sapiens_hsa030221.38368405
39Toxoplasmosis_Homo sapiens_hsa051451.36090057
40Inositol phosphate metabolism_Homo sapiens_hsa005621.35280732
41Basal cell carcinoma_Homo sapiens_hsa052171.34291164
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29451821
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28733437
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25517077
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24987589
46Pancreatic cancer_Homo sapiens_hsa052121.22338816
47Hippo signaling pathway_Homo sapiens_hsa043901.19958035
48Tuberculosis_Homo sapiens_hsa051521.18978479
49Hematopoietic cell lineage_Homo sapiens_hsa046401.18527468
50Epstein-Barr virus infection_Homo sapiens_hsa051691.16765456
51Hedgehog signaling pathway_Homo sapiens_hsa043401.15137020
52MicroRNAs in cancer_Homo sapiens_hsa052061.14280729
53Lysine degradation_Homo sapiens_hsa003101.14068405
54Renal cell carcinoma_Homo sapiens_hsa052111.12407345
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12144668
56Measles_Homo sapiens_hsa051621.12002698
57VEGF signaling pathway_Homo sapiens_hsa043701.09469609
58Protein export_Homo sapiens_hsa030601.05352422
59Small cell lung cancer_Homo sapiens_hsa052221.05318744
60Selenocompound metabolism_Homo sapiens_hsa004501.04547420
61Viral carcinogenesis_Homo sapiens_hsa052031.03972714
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00311425
63HTLV-I infection_Homo sapiens_hsa051660.94418029
64Notch signaling pathway_Homo sapiens_hsa043300.93610102
65Thyroid cancer_Homo sapiens_hsa052160.92150154
66Bladder cancer_Homo sapiens_hsa052190.89507852
67Adherens junction_Homo sapiens_hsa045200.89179963
68Hepatitis C_Homo sapiens_hsa051600.88767823
69Antigen processing and presentation_Homo sapiens_hsa046120.88738016
70Chronic myeloid leukemia_Homo sapiens_hsa052200.88028361
71Choline metabolism in cancer_Homo sapiens_hsa052310.87439209
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85895634
73mTOR signaling pathway_Homo sapiens_hsa041500.85844004
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84163708
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82786118
76Herpes simplex infection_Homo sapiens_hsa051680.81726024
77B cell receptor signaling pathway_Homo sapiens_hsa046620.79658269
78ErbB signaling pathway_Homo sapiens_hsa040120.77765121
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.73275965
80TGF-beta signaling pathway_Homo sapiens_hsa043500.73224473
81Prostate cancer_Homo sapiens_hsa052150.72187199
82Systemic lupus erythematosus_Homo sapiens_hsa053220.72165468
83Galactose metabolism_Homo sapiens_hsa000520.70636363
84Oocyte meiosis_Homo sapiens_hsa041140.69585048
85Purine metabolism_Homo sapiens_hsa002300.68962940
86Chemokine signaling pathway_Homo sapiens_hsa040620.65690800
87Pathways in cancer_Homo sapiens_hsa052000.64870806
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64247817
89Glioma_Homo sapiens_hsa052140.63947489
90* Lysosome_Homo sapiens_hsa041420.63000603
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.61630676
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.61290861
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.60298764
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58945986
95Melanoma_Homo sapiens_hsa052180.58772671
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.58656516
97Proteoglycans in cancer_Homo sapiens_hsa052050.58475924
98N-Glycan biosynthesis_Homo sapiens_hsa005100.57135391
99Long-term potentiation_Homo sapiens_hsa047200.56925751
100Endometrial cancer_Homo sapiens_hsa052130.56448792
101TNF signaling pathway_Homo sapiens_hsa046680.55855058
102Apoptosis_Homo sapiens_hsa042100.54862635
103Wnt signaling pathway_Homo sapiens_hsa043100.53399317
104Platelet activation_Homo sapiens_hsa046110.52241331
105GnRH signaling pathway_Homo sapiens_hsa049120.52136867
106Colorectal cancer_Homo sapiens_hsa052100.51574781
107Non-small cell lung cancer_Homo sapiens_hsa052230.51383503
108Acute myeloid leukemia_Homo sapiens_hsa052210.51341298
109Insulin signaling pathway_Homo sapiens_hsa049100.51095706
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50953798
111Tight junction_Homo sapiens_hsa045300.50751102
112Primary immunodeficiency_Homo sapiens_hsa053400.49792900
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48728659
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.48674607
115Other glycan degradation_Homo sapiens_hsa005110.48468207
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48060605
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46924557
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46513906
119Folate biosynthesis_Homo sapiens_hsa007900.46307294
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45201548
121Fructose and mannose metabolism_Homo sapiens_hsa000510.44754435
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.44683265
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44332090
124Phagosome_Homo sapiens_hsa041450.43484516
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.42887264
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42878593
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.41661445
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41541305
129Biosynthesis of amino acids_Homo sapiens_hsa012300.41007806
130Focal adhesion_Homo sapiens_hsa045100.40874419
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40342864
132FoxO signaling pathway_Homo sapiens_hsa040680.39842053
133Protein digestion and absorption_Homo sapiens_hsa049740.39804253
134Estrogen signaling pathway_Homo sapiens_hsa049150.39230591
135HIF-1 signaling pathway_Homo sapiens_hsa040660.38646726
136Type II diabetes mellitus_Homo sapiens_hsa049300.37843502
137AMPK signaling pathway_Homo sapiens_hsa041520.36792624
138ECM-receptor interaction_Homo sapiens_hsa045120.35847196
139Pentose phosphate pathway_Homo sapiens_hsa000300.35794294
140Alcoholism_Homo sapiens_hsa050340.35010467
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34379222
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34368385
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.34055600
144Hepatitis B_Homo sapiens_hsa051610.33763827
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33313045
146Sulfur relay system_Homo sapiens_hsa041220.30709770
147Viral myocarditis_Homo sapiens_hsa054160.30593272
148Legionellosis_Homo sapiens_hsa051340.30240084
149Prolactin signaling pathway_Homo sapiens_hsa049170.29021589
150Insulin resistance_Homo sapiens_hsa049310.28168662
151Renin-angiotensin system_Homo sapiens_hsa046140.26073304
1522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25191145

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