GGA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.10987440
2mannose metabolic process (GO:0006013)4.37343429
3positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.13651789
4response to muramyl dipeptide (GO:0032495)4.09654241
5response to peptidoglycan (GO:0032494)4.07637060
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07587587
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.07587587
8modulation by symbiont of host immune response (GO:0052553)4.07587587
9positive regulation by symbiont of host defense response (GO:0052509)4.07587587
10modulation by symbiont of host defense response (GO:0052031)4.07587587
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07587587
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.96620137
13antigen processing and presentation of endogenous antigen (GO:0019883)3.87306365
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77455629
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.74614961
16regulation of interferon-beta biosynthetic process (GO:0045357)3.72895858
17histone H3-K4 trimethylation (GO:0080182)3.68915077
18detection of bacterium (GO:0016045)3.67791529
19detection of other organism (GO:0098543)3.65166935
20pre-miRNA processing (GO:0031054)3.63085487
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59734243
22negative regulation of cell killing (GO:0031342)3.59734243
23histone H3-K4 methylation (GO:0051568)3.55459130
24synaptic vesicle maturation (GO:0016188)3.52198955
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.51487010
26histone H3-K36 demethylation (GO:0070544)3.46056729
27negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.41989137
28histone H4-K12 acetylation (GO:0043983)3.39296307
29locomotory exploration behavior (GO:0035641)3.29989217
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.29960031
31regulation of type I interferon-mediated signaling pathway (GO:0060338)3.25301139
32negative regulation of toll-like receptor signaling pathway (GO:0034122)3.17540680
33leukocyte aggregation (GO:0070486)3.17123427
34detection of external biotic stimulus (GO:0098581)3.12727873
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.10646020
36regulation of mast cell degranulation (GO:0043304)3.09371313
37germinal center formation (GO:0002467)3.08966658
38neutrophil activation involved in immune response (GO:0002283)3.08757083
39synaptic vesicle endocytosis (GO:0048488)3.08646164
40histone H4-K8 acetylation (GO:0043982)3.08046581
41histone H4-K5 acetylation (GO:0043981)3.08046581
42modulation by symbiont of host cellular process (GO:0044068)3.07400086
43histone H4 deacetylation (GO:0070933)3.06838365
44regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.04677815
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.02804678
46regulation of leukocyte degranulation (GO:0043300)3.01056249
47immunoglobulin mediated immune response (GO:0016064)3.00919577
483-UTR-mediated mRNA stabilization (GO:0070935)2.99280955
49positive regulation of B cell differentiation (GO:0045579)2.98619107
50cellular response to virus (GO:0098586)2.97865905
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97783409
52histone H4-K16 acetylation (GO:0043984)2.97703839
53GDP-mannose metabolic process (GO:0019673)2.95486622
54regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95369380
55phosphatidylglycerol biosynthetic process (GO:0006655)2.91788349
56negative regulation of interleukin-12 production (GO:0032695)2.89777132
57detection of molecule of bacterial origin (GO:0032490)2.85973440
58negative regulation of T cell mediated immunity (GO:0002710)2.85857864
59positive regulation of gamma-delta T cell activation (GO:0046645)2.85282397
60positive regulation of gene expression, epigenetic (GO:0045815)2.85165803
61CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.84071775
62negative regulation of granulocyte differentiation (GO:0030853)2.83612373
63negative regulation of histone methylation (GO:0031061)2.82587071
64ionotropic glutamate receptor signaling pathway (GO:0035235)2.81862292
65adenosine receptor signaling pathway (GO:0001973)2.81855734
66synaptic vesicle exocytosis (GO:0016079)2.81813772
67regulation of B cell differentiation (GO:0045577)2.79818387
68regulation of histone H3-K27 methylation (GO:0061085)2.78874680
69regulation of mast cell activation involved in immune response (GO:0033006)2.78413634
70response to host (GO:0075136)2.77910608
71response to host defenses (GO:0052200)2.77910608
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77910608
73response to host immune response (GO:0052572)2.77544538
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77544538
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76242287
76positive regulation of interferon-alpha production (GO:0032727)2.75925192
77regulation of glutamate receptor signaling pathway (GO:1900449)2.75719965
78myeloid cell activation involved in immune response (GO:0002275)2.75653479
79regulation of ARF protein signal transduction (GO:0032012)2.75027508
80negative regulation of translation, ncRNA-mediated (GO:0040033)2.74694728
81regulation of translation, ncRNA-mediated (GO:0045974)2.74694728
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74694728
83regulation of T-helper 2 cell differentiation (GO:0045628)2.74507829
84megakaryocyte development (GO:0035855)2.73464550
85negative thymic T cell selection (GO:0045060)2.73112572
86response to type I interferon (GO:0034340)2.72920017
87cellular extravasation (GO:0045123)2.72121659
88negative regulation of lymphocyte mediated immunity (GO:0002707)2.71451921
89detection of biotic stimulus (GO:0009595)2.70991047
90tolerance induction (GO:0002507)2.69615495
91negative T cell selection (GO:0043383)2.69123119
92regulation of NFAT protein import into nucleus (GO:0051532)2.68916511
93negative regulation of innate immune response (GO:0045824)2.68429996
94cellular response to type I interferon (GO:0071357)2.68172375
95type I interferon signaling pathway (GO:0060337)2.68172375
96response to interleukin-15 (GO:0070672)2.68009976
97T cell migration (GO:0072678)2.67726144
98embryonic process involved in female pregnancy (GO:0060136)2.67395194
99histone lysine methylation (GO:0034968)2.65901265
100regulation of interleukin-2 biosynthetic process (GO:0045076)2.65571981
101regulation of T cell tolerance induction (GO:0002664)2.62540176
102cerebellar Purkinje cell differentiation (GO:0021702)2.60853712
103positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60512388
104negative regulation of leukocyte mediated immunity (GO:0002704)2.60379333
105response to laminar fluid shear stress (GO:0034616)2.60282688
106regulation of synaptic vesicle exocytosis (GO:2000300)2.59997542
107positive thymic T cell selection (GO:0045059)2.58954963
108G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.58417305
109defense response to protozoan (GO:0042832)2.58402669
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.56584084
111positive T cell selection (GO:0043368)2.55338110
112natural killer cell differentiation (GO:0001779)2.55169191
113B cell homeostasis (GO:0001782)2.54868818
114positive regulation of Rap GTPase activity (GO:0032854)2.53477589
115synaptic transmission, glutamatergic (GO:0035249)2.52923566
116glutamate secretion (GO:0014047)2.52678431
117vocalization behavior (GO:0071625)2.52605851
118peptidyl-lysine trimethylation (GO:0018023)2.52306713
119regulation of interferon-alpha production (GO:0032647)2.51530601
120respiratory burst (GO:0045730)2.51210487
121histone methylation (GO:0016571)2.50960788
122proline transport (GO:0015824)2.48179012
123T cell selection (GO:0045058)2.47109554
124long-term memory (GO:0007616)2.44431003
125regulation of B cell receptor signaling pathway (GO:0050855)2.43810482
126regulation of Rap GTPase activity (GO:0032317)2.43202844
127regulation of synaptic vesicle transport (GO:1902803)2.42274087
128NIK/NF-kappaB signaling (GO:0038061)2.42111845
129B cell receptor signaling pathway (GO:0050853)2.40432143
130regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.40246865
131thymic T cell selection (GO:0045061)2.40055697
132interferon-gamma production (GO:0032609)2.39207715
133positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.38462676
134protein localization to synapse (GO:0035418)2.37974110
135sodium ion export (GO:0071436)2.37076633
136intracellular estrogen receptor signaling pathway (GO:0030520)2.36647672
137histone H4 acetylation (GO:0043967)2.34811322
138peptidyl-arginine methylation (GO:0018216)2.34516030
139peptidyl-arginine N-methylation (GO:0035246)2.34516030
140G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.34274542
141positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.27615830
142positive regulation of granulocyte differentiation (GO:0030854)2.27607875
143layer formation in cerebral cortex (GO:0021819)2.27269724
144regulation of interleukin-12 biosynthetic process (GO:0045075)2.25474522
145neuronal action potential propagation (GO:0019227)2.25277672
146positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.25034986
147regulation of neuronal synaptic plasticity (GO:0048168)2.24087019
148regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.22867549
149histone deubiquitination (GO:0016578)2.22752247
150tachykinin receptor signaling pathway (GO:0007217)2.22483389
151regulation of ARF GTPase activity (GO:0032312)2.21756705
152nuclear pore complex assembly (GO:0051292)2.21159004
153glutamate receptor signaling pathway (GO:0007215)2.20686861
154regulation of telomere maintenance via telomerase (GO:0032210)2.19936906
155neuron cell-cell adhesion (GO:0007158)2.17712904
156regulation of excitatory postsynaptic membrane potential (GO:0060079)2.17414492
157regulation of long-term neuronal synaptic plasticity (GO:0048169)2.16216956
158neuron-neuron synaptic transmission (GO:0007270)2.15044923
159modulation by virus of host process (GO:0019054)2.13730812
160neurotransmitter secretion (GO:0007269)2.13024622
161membrane depolarization during action potential (GO:0086010)2.12166506
162neuromuscular process controlling balance (GO:0050885)2.11216671
163positive regulation of synapse maturation (GO:0090129)2.09713397
164macrophage activation involved in immune response (GO:0002281)2.08474109
165maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.08306492
166regulation of gamma-delta T cell differentiation (GO:0045586)2.07038462
167regulation of gamma-delta T cell activation (GO:0046643)2.06706884
168positive regulation of membrane potential (GO:0045838)2.06486123
169regulation of postsynaptic membrane potential (GO:0060078)2.06428890
170peptidyl-threonine phosphorylation (GO:0018107)2.06288046
171cytoplasmic mRNA processing body assembly (GO:0033962)2.06281412
172G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.05936471
173positive regulation of RNA splicing (GO:0033120)2.04305189
174regulation of chromatin binding (GO:0035561)2.04177560
175pore complex assembly (GO:0046931)2.02433144
176exploration behavior (GO:0035640)2.01865787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.17278706
2MYC_22102868_ChIP-Seq_BL_Human3.19251890
3EZH2_22144423_ChIP-Seq_EOC_Human3.08532772
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.86109286
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.83164742
6LXR_22292898_ChIP-Seq_THP-1_Human2.69342970
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68834155
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.61787904
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.54844150
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42208875
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.36582479
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.13917234
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.12678047
14TCF7_22412390_ChIP-Seq_EML_Mouse2.08012879
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96953240
16KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94198315
17KDM2B_26808549_Chip-Seq_DND41_Human1.92754180
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92521364
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92252885
20P68_20966046_ChIP-Seq_HELA_Human1.90610902
21RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.89206352
22RACK7_27058665_Chip-Seq_MCF-7_Human1.86632222
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85088428
24DROSHA_22980978_ChIP-Seq_HELA_Human1.84751378
25CIITA_25753668_ChIP-Seq_RAJI_Human1.84385408
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.79220642
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76696115
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72167934
29REST_21632747_ChIP-Seq_MESCs_Mouse1.69687566
30CTCF_27219007_Chip-Seq_ERYTHROID_Human1.68378171
31KDM2B_26808549_Chip-Seq_K562_Human1.67162945
32SPI1_23127762_ChIP-Seq_K562_Human1.64220770
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62230365
34* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60687921
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58896999
36NCOR1_26117541_ChIP-Seq_K562_Human1.57477493
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57248913
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55379485
39BCOR_27268052_Chip-Seq_Bcells_Human1.55368909
40* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53806686
41* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53582224
42RUNX_20019798_ChIP-Seq_JUKART_Human1.53463191
43* VDR_21846776_ChIP-Seq_THP-1_Human1.53269238
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51233968
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49957275
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49758752
47BCL6_27268052_Chip-Seq_Bcells_Human1.49685828
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49022639
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.47446410
50* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47168676
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47153708
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47036623
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.46533813
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.44984698
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.43338995
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42476808
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.41712749
58SCL_19346495_ChIP-Seq_HPC-7_Human1.40447702
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40408836
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39301180
61* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39100939
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38391360
63SPI1_23547873_ChIP-Seq_NB4_Human1.38270612
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38213661
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37932609
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37868632
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36837147
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.36698880
69PU.1_20513432_ChIP-Seq_Bcells_Mouse1.36151137
70UTX_26944678_Chip-Seq_JUKART_Human1.36047236
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35524593
72* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35041784
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32858745
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32577536
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26851307
76NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25911000
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25469217
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25073920
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.24912964
80CREB1_26743006_Chip-Seq_LNCaP_Human1.24756526
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23897145
82MAF_26560356_Chip-Seq_TH1_Human1.23477540
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.23146880
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22108087
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.20589139
86PHF8_20622854_ChIP-Seq_HELA_Human1.20015082
87E2F1_20622854_ChIP-Seq_HELA_Human1.19115861
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18862310
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18703480
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18492229
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18467868
92GATA1_19941826_ChIP-Seq_K562_Human1.17216634
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16627445
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16627445
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16627445
96IRF8_21731497_ChIP-ChIP_J774_Mouse1.16099444
97MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15498880
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.15155779
99CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13512153
100* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13502164
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12232864
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12118132
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11884314
104MYB_26560356_Chip-Seq_TH2_Human1.11671323
105CTCF_21964334_Chip-Seq_Bcells_Human1.11529431
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11033235
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08850627
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08534900
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07909186
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07751018
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07557226
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06901885
113RARA_24833708_ChIP-Seq_LIVER_Mouse1.06821436
114ETS1_21867929_ChIP-Seq_TH2_Mouse1.06634514
115SMAD_19615063_ChIP-ChIP_OVARY_Human1.06210971
116MYB_26560356_Chip-Seq_TH1_Human1.05453901
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05075979
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05072498
119* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04921870
120GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04906531
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04428390
122RARB_24833708_ChIP-Seq_LIVER_Mouse1.04249143
123SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03157568
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02598736
125RUNX1_27514584_Chip-Seq_MCF-7_Human1.02434644
126IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99710759
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96025664
128GBX2_23144817_ChIP-Seq_PC3_Human0.95583369
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.93720748
130POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93205499
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93051069
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92635310
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91383081
134* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90895245
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90894126
136STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90004155
137RUNX1_22412390_ChIP-Seq_EML_Mouse0.89406183
138MAF_26560356_Chip-Seq_TH2_Human0.88880908
139SMC4_20622854_ChIP-Seq_HELA_Human0.88582465
140E2F1_21310950_ChIP-Seq_MCF-7_Human0.87892992
141SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.87126642
142DPY_21335234_ChIP-Seq_ESCs_Mouse0.86374185
143PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86131688
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85986119
145IRF8_22096565_ChIP-ChIP_GC-B_Human0.85564909
146TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84832835
147IRF8_27001747_Chip-Seq_BMDM_Mouse0.84560337
148YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84235682
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83621993
150VDR_24763502_ChIP-Seq_THP-1_Human0.83077866
151POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82925193
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80812996
153RNF2_27304074_Chip-Seq_ESCs_Mouse0.79824582
154SALL1_21062744_ChIP-ChIP_HESCs_Human0.79804976
155SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79096886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.17902942
2MP0003436_decreased_susceptibility_to3.56115238
3MP0003787_abnormal_imprinting3.54239939
4MP0000569_abnormal_digit_pigmentation3.41359331
5MP0008057_abnormal_DNA_replication2.55747808
6MP0005451_abnormal_body_composition2.47249523
7MP0004270_analgesia2.45642202
8MP0003635_abnormal_synaptic_transmissio2.45041336
9MP0003880_abnormal_central_pattern2.38455988
10MP0005409_darkened_coat_color2.33318363
11MP0005058_abnormal_lysosome_morphology2.29179124
12MP0005423_abnormal_somatic_nervous2.18599434
13MP0002419_abnormal_innate_immunity2.17580117
14MP0005025_abnormal_response_to2.16069199
15MP0001986_abnormal_taste_sensitivity2.13527155
16MP0008260_abnormal_autophagy2.08032753
17MP0008877_abnormal_DNA_methylation2.01705737
18MP0005310_abnormal_salivary_gland1.93615355
19MP0004381_abnormal_hair_follicle1.91451976
20MP0002063_abnormal_learning/memory/cond1.89956987
21MP0003705_abnormal_hypodermis_morpholog1.89635714
22MP0003300_gastrointestinal_ulcer1.89332336
23MP0003724_increased_susceptibility_to1.87440962
24MP0002653_abnormal_ependyma_morphology1.86355961
25MP0004947_skin_inflammation1.85226434
26MP0004510_myositis1.78212889
27MP0005171_absent_coat_pigmentation1.77191407
28MP0003111_abnormal_nucleus_morphology1.71068921
29MP0002064_seizures1.70940150
30MP0009046_muscle_twitch1.69999734
31MP0009745_abnormal_behavioral_response1.68623790
32MP0001835_abnormal_antigen_presentation1.66986497
33MP0003453_abnormal_keratinocyte_physiol1.66010394
34MP0005464_abnormal_platelet_physiology1.61885271
35MP0003121_genomic_imprinting1.60315132
36MP0002572_abnormal_emotion/affect_behav1.56727693
37MP0002148_abnormal_hypersensitivity_rea1.53123313
38MP0005671_abnormal_response_to1.51808574
39MP0010094_abnormal_chromosome_stability1.51315611
40MP0001486_abnormal_startle_reflex1.51154778
41MP0003172_abnormal_lysosome_physiology1.49479336
42MP0010155_abnormal_intestine_physiology1.48990463
43MP0004185_abnormal_adipocyte_glucose1.44119986
44MP0002396_abnormal_hematopoietic_system1.43638538
45MP0005394_taste/olfaction_phenotype1.42970128
46MP0005499_abnormal_olfactory_system1.42970128
47MP0001968_abnormal_touch/_nociception1.42805809
48MP0009785_altered_susceptibility_to1.42271035
49MP0002734_abnormal_mechanical_nocicepti1.41169987
50MP0008961_abnormal_basal_metabolism1.39397982
51MP0000858_altered_metastatic_potential1.37470204
52MP0001800_abnormal_humoral_immune1.36454079
53MP0003763_abnormal_thymus_physiology1.35928734
54MP0008569_lethality_at_weaning1.35122615
55MP0002822_catalepsy1.34911659
56MP0003077_abnormal_cell_cycle1.33797536
57MP0003303_peritoneal_inflammation1.30599851
58MP0001348_abnormal_lacrimal_gland1.29610747
59MP0009840_abnormal_foam_cell1.29299478
60MP0002272_abnormal_nervous_system1.28847345
61MP0006292_abnormal_olfactory_placode1.28609334
62MP0001533_abnormal_skeleton_physiology1.28192442
63MP0003091_abnormal_cell_migration1.27021734
64MP0002398_abnormal_bone_marrow1.26834892
65MP0003183_abnormal_peptide_metabolism1.25186135
66MP0000703_abnormal_thymus_morphology1.24312086
67MP0005083_abnormal_biliary_tract1.21982435
68MP0004811_abnormal_neuron_physiology1.21923729
69MP0000685_abnormal_immune_system1.21776789
70MP0004808_abnormal_hematopoietic_stem1.20114262
71MP0003656_abnormal_erythrocyte_physiolo1.18647467
72MP0002132_abnormal_respiratory_system1.18554763
73MP0001845_abnormal_inflammatory_respons1.18322343
74MP0002184_abnormal_innervation1.18038953
75MP0002735_abnormal_chemical_nociception1.17301955
76MP0003879_abnormal_hair_cell1.16739067
77MP0000778_abnormal_nervous_system1.16129476
78MP0002998_abnormal_bone_remodeling1.14445402
79MP0006082_CNS_inflammation1.11900686
80MP0000955_abnormal_spinal_cord1.11188864
81MP0003191_abnormal_cellular_cholesterol1.10543169
82MP0002067_abnormal_sensory_capabilities1.09676410
83MP0000015_abnormal_ear_pigmentation1.09552983
84MP0001970_abnormal_pain_threshold1.08577633
85MP0002736_abnormal_nociception_after1.08444719
86MP0003123_paternal_imprinting1.07806173
87MP0001501_abnormal_sleep_pattern1.07635944
88MP0000490_abnormal_crypts_of1.05977526
89MP0002733_abnormal_thermal_nociception1.04474667
90MP0002254_reproductive_system_inflammat1.02868360
91MP0002452_abnormal_antigen_presenting1.02576785
92MP0008469_abnormal_protein_level1.01178721
93MP0009278_abnormal_bone_marrow1.00786817
94MP0002420_abnormal_adaptive_immunity1.00482123
95MP0002933_joint_inflammation0.99702269
96MP0001819_abnormal_immune_cell0.99348772
97MP0000716_abnormal_immune_system0.98743238
98MP0005387_immune_system_phenotype0.98728800
99MP0001790_abnormal_immune_system0.98728800
100MP0001440_abnormal_grooming_behavior0.98268011
101MP0005666_abnormal_adipose_tissue0.97778302
102MP0005000_abnormal_immune_tolerance0.97496639
103MP0008058_abnormal_DNA_repair0.96859023
104MP0004924_abnormal_behavior0.96856778
105MP0005386_behavior/neurological_phenoty0.96856778
106MP0000678_abnormal_parathyroid_gland0.96187188
107MP0002722_abnormal_immune_system0.95821876
108MP0000350_abnormal_cell_proliferation0.95265196
109MP0002723_abnormal_immune_serum0.95206189
110MP0005174_abnormal_tail_pigmentation0.94478283
111MP0005076_abnormal_cell_differentiation0.94460813
112MP0004264_abnormal_extraembryonic_tissu0.94435488
113MP0002019_abnormal_tumor_incidence0.94265201
114MP0000689_abnormal_spleen_morphology0.92769008
115MP0003693_abnormal_embryo_hatching0.92217518
116MP0003828_pulmonary_edema0.92070575
117MP0004858_abnormal_nervous_system0.91419202
118MP0002166_altered_tumor_susceptibility0.89708065
119MP0003448_altered_tumor_morphology0.89405977
120MP0008007_abnormal_cellular_replicative0.87168166
121MP0004885_abnormal_endolymph0.86961250
122MP0005646_abnormal_pituitary_gland0.86699842
123MP0002882_abnormal_neuron_morphology0.86521135
124MP0009333_abnormal_splenocyte_physiolog0.86425559
125MP0002163_abnormal_gland_morphology0.85660958
126MP0003136_yellow_coat_color0.84584832
127MP0002557_abnormal_social/conspecific_i0.84386401
128MP0003866_abnormal_defecation0.83896515
129MP0001851_eye_inflammation0.83531891
130MP0001502_abnormal_circadian_rhythm0.83303511
131MP0002152_abnormal_brain_morphology0.83200277
132MP0010307_abnormal_tumor_latency0.83156504
133MP0005375_adipose_tissue_phenotype0.82204771
134MP0009931_abnormal_skin_appearance0.82025440
135MP0003045_fibrosis0.81977554
136MP0004130_abnormal_muscle_cell0.81417142
137MP0005397_hematopoietic_system_phenotyp0.79006623
138MP0001545_abnormal_hematopoietic_system0.79006623
139MP0002405_respiratory_system_inflammati0.78295851
140MP0003861_abnormal_nervous_system0.77333387
141MP0002429_abnormal_blood_cell0.77252770
142MP0002066_abnormal_motor_capabilities/c0.77040583
143MP0002909_abnormal_adrenal_gland0.75927763
144MP0000003_abnormal_adipose_tissue0.75697633
145MP0001853_heart_inflammation0.75251094
146MP0001188_hyperpigmentation0.75021972
147MP0000313_abnormal_cell_death0.72842289
148MP0005645_abnormal_hypothalamus_physiol0.71853465
149MP0001873_stomach_inflammation0.69625849
150MP0001849_ear_inflammation0.69049038
151MP0005621_abnormal_cell_physiology0.68273355
152MP0003329_amyloid_beta_deposits0.68199101
153MP0002009_preneoplasia0.67756626
154MP0005501_abnormal_skin_physiology0.67323810
155MP0008874_decreased_physiological_sensi0.66703151
156MP0003690_abnormal_glial_cell0.64223939
157MP0003566_abnormal_cell_adhesion0.61700394

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.31171060
2Abnormality of the fingertips (HP:0001211)3.53806364
3Focal motor seizures (HP:0011153)3.43768704
4Febrile seizures (HP:0002373)3.43185899
5Thin bony cortex (HP:0002753)3.38966911
6Abnormality of macrophages (HP:0004311)3.34957130
7Gastrointestinal infarctions (HP:0005244)3.27016213
8Hemorrhage of the eye (HP:0011885)3.15536096
9Pustule (HP:0200039)3.07041123
10Focal seizures (HP:0007359)3.02865130
11Urethral obstruction (HP:0000796)2.95874221
12Cellulitis (HP:0100658)2.90049180
13Visual hallucinations (HP:0002367)2.77716726
14Ependymoma (HP:0002888)2.73944602
15Gastrointestinal inflammation (HP:0004386)2.73183041
16Epileptic encephalopathy (HP:0200134)2.73144101
17Ulnar bowing (HP:0003031)2.72497999
18Chronic obstructive pulmonary disease (HP:0006510)2.72240075
19Obstructive lung disease (HP:0006536)2.72240075
20Meningitis (HP:0001287)2.70802537
21Testicular atrophy (HP:0000029)2.69778575
22Increased IgE level (HP:0003212)2.68472504
23Atonic seizures (HP:0010819)2.65142888
24Poikiloderma (HP:0001029)2.61730607
25Mediastinal lymphadenopathy (HP:0100721)2.56198622
26Inflammation of the large intestine (HP:0002037)2.53119232
27Recurrent skin infections (HP:0001581)2.52359925
28Basal cell carcinoma (HP:0002671)2.48899661
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48477783
30Intestinal fistula (HP:0100819)2.43095867
31Metaphyseal cupping (HP:0003021)2.39250539
32Abnormality of the lower motor neuron (HP:0002366)2.38831425
33Turricephaly (HP:0000262)2.38674634
34Vasculitis (HP:0002633)2.36817552
35Myokymia (HP:0002411)2.36781591
36Recurrent gram-negative bacterial infections (HP:0005420)2.35630826
37Chromsome breakage (HP:0040012)2.35095813
38Abnormality of the astrocytes (HP:0100707)2.35078299
39Astrocytoma (HP:0009592)2.35078299
40Gastrointestinal stroma tumor (HP:0100723)2.34315105
41Joint hemorrhage (HP:0005261)2.33776645
42Pointed chin (HP:0000307)2.33730506
43Hyperacusis (HP:0010780)2.30573288
44Slow saccadic eye movements (HP:0000514)2.29571032
45Epistaxis (HP:0000421)2.29110429
46Retrobulbar optic neuritis (HP:0100654)2.28550671
47Optic neuritis (HP:0100653)2.28550671
48Emphysema (HP:0002097)2.27981917
49Gingivitis (HP:0000230)2.24553217
50Vaginal fistula (HP:0004320)2.22981341
51Impaired smooth pursuit (HP:0007772)2.22745242
52Prolonged bleeding time (HP:0003010)2.21592258
53Abnormality of the labia minora (HP:0012880)2.19158257
54Spontaneous hematomas (HP:0007420)2.16090887
55Hypochromic anemia (HP:0001931)2.13013017
56Abnormality of ocular smooth pursuit (HP:0000617)2.10124197
57Rectovaginal fistula (HP:0000143)2.09898491
58Rectal fistula (HP:0100590)2.09898491
59Dysostosis multiplex (HP:0000943)2.09853638
60Anal stenosis (HP:0002025)2.09337236
61Orchitis (HP:0100796)2.09163752
62Heterotopia (HP:0002282)2.08735584
63Hypertensive crisis (HP:0100735)2.07725852
64Panhypogammaglobulinemia (HP:0003139)2.07659336
65Chest pain (HP:0100749)2.07205123
66Myositis (HP:0100614)2.07164545
67Urinary bladder sphincter dysfunction (HP:0002839)2.06938077
68Easy fatigability (HP:0003388)2.06197321
69Broad face (HP:0000283)2.05968654
70Obstructive sleep apnea (HP:0002870)2.04912836
71Absence seizures (HP:0002121)2.02654658
72Anteriorly placed anus (HP:0001545)2.02248278
73Elevated erythrocyte sedimentation rate (HP:0003565)2.00878731
74Neoplasm of the oral cavity (HP:0100649)2.00673863
75Acute lymphatic leukemia (HP:0006721)1.99418825
76Progressive cerebellar ataxia (HP:0002073)1.99211345
77Thin ribs (HP:0000883)1.97779388
78Osteomyelitis (HP:0002754)1.97758309
79Birth length less than 3rd percentile (HP:0003561)1.96245595
80Supranuclear gaze palsy (HP:0000605)1.95817442
81Volvulus (HP:0002580)1.94898756
82Urinary glycosaminoglycan excretion (HP:0003541)1.94832888
83Mucopolysacchariduria (HP:0008155)1.94832888
84Squamous cell carcinoma (HP:0002860)1.94272577
85Dialeptic seizures (HP:0011146)1.93892706
86Neuronal loss in central nervous system (HP:0002529)1.93801521
87Rib fusion (HP:0000902)1.93756793
88Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93694448
89Abnormality of polysaccharide metabolism (HP:0011012)1.93694448
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93694448
91Chronic mucocutaneous candidiasis (HP:0002728)1.93052216
92Recurrent cutaneous fungal infections (HP:0011370)1.93052216
93Recurrent fungal infections (HP:0002841)1.91693145
94Encephalitis (HP:0002383)1.91006547
95Genetic anticipation (HP:0003743)1.89532517
96Prominent nose (HP:0000448)1.88013459
97Segmental peripheral demyelination/remyelination (HP:0003481)1.86923162
98Inappropriate behavior (HP:0000719)1.86826354
99Annular pancreas (HP:0001734)1.85109387
100Trigonocephaly (HP:0000243)1.84717308
101Cheilitis (HP:0100825)1.84551479
102Long eyelashes (HP:0000527)1.84370942
103Agammaglobulinemia (HP:0004432)1.84220183
104Increased serum ferritin (HP:0003281)1.83899541
105Protruding tongue (HP:0010808)1.83840005
106Impaired vibration sensation in the lower limbs (HP:0002166)1.83482405
107Glioma (HP:0009733)1.83062305
108Colitis (HP:0002583)1.83029533
109Agnosia (HP:0010524)1.83015889
110Myopathic facies (HP:0002058)1.82818699
111Truncal ataxia (HP:0002078)1.81897439
112Lip pit (HP:0100267)1.81865702
113Ectopic kidney (HP:0000086)1.81537792
114Urticaria (HP:0001025)1.80850067
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.79856542
116Arterial thrombosis (HP:0004420)1.79780233
117Myelodysplasia (HP:0002863)1.79692288
118Restrictive lung disease (HP:0002091)1.78764368
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.78155357
120Abnormality of the thoracic spine (HP:0100711)1.77477164
121Gaze-evoked nystagmus (HP:0000640)1.76662320
122Ankle clonus (HP:0011448)1.76038540
123Capillary hemangiomas (HP:0005306)1.75585476
124Lymphopenia (HP:0001888)1.75522284
125Abnormality of glycolipid metabolism (HP:0010969)1.75121324
126Abnormality of liposaccharide metabolism (HP:0010968)1.75121324
127Abnormality of glycosphingolipid metabolism (HP:0004343)1.75121324
128Patellar aplasia (HP:0006443)1.73878814
129Insomnia (HP:0100785)1.72872624
130Progressive external ophthalmoplegia (HP:0000590)1.72111291
131Stomatitis (HP:0010280)1.71502973
132Joint stiffness (HP:0001387)1.71303103
133Increased cerebral lipofuscin (HP:0011813)1.70773190
134Hypertriglyceridemia (HP:0002155)1.70335391
135Recurrent viral infections (HP:0004429)1.70202064
136Disproportionate tall stature (HP:0001519)1.70073958
137Postural instability (HP:0002172)1.69914009
138Delayed epiphyseal ossification (HP:0002663)1.69476482
139Abnormality of cells of the lymphoid lineage (HP:0012140)1.69227990
140Pulmonary infiltrates (HP:0002113)1.67836559
141Papilloma (HP:0012740)1.67570139
142Verrucae (HP:0200043)1.67570139
143Tented upper lip vermilion (HP:0010804)1.66639105
144Anorexia (HP:0002039)1.66167445
145Akinesia (HP:0002304)1.65667032
146Medulloblastoma (HP:0002885)1.65546830
147Stereotypic behavior (HP:0000733)1.65404508
148Fatigue (HP:0012378)1.65379410
149Recurrent abscess formation (HP:0002722)1.63945898
150Abnormality of the common coagulation pathway (HP:0010990)1.63802504
151Polycythemia (HP:0001901)1.63529839
152Long palpebral fissure (HP:0000637)1.63048885
153Skin tags (HP:0010609)1.62581285
154Papillary thyroid carcinoma (HP:0002895)1.62524619
155Lower limb amyotrophy (HP:0007210)1.62499829
156Abnormal hair whorl (HP:0010721)1.62005467
157Elfin facies (HP:0004428)1.61434827
158Failure to thrive in infancy (HP:0001531)1.61124231
159Poor eye contact (HP:0000817)1.60837840
160Amyotrophic lateral sclerosis (HP:0007354)1.60672870
161Dysmetric saccades (HP:0000641)1.60599853
162Abnormality of the carotid arteries (HP:0005344)1.60049124
163Mask-like facies (HP:0000298)1.59693876
164Spinal canal stenosis (HP:0003416)1.59184726
165Recurrent bacterial skin infections (HP:0005406)1.59050582
166Neoplasm of the heart (HP:0100544)1.58972432
167Hemiplegia (HP:0002301)1.57392418
168Shawl scrotum (HP:0000049)1.57331498
169Diplopia (HP:0000651)1.56965635
170Abnormality of binocular vision (HP:0011514)1.56965635
171Facial hemangioma (HP:0000329)1.56749122
172Broad-based gait (HP:0002136)1.56491471
173Clubbing of toes (HP:0100760)1.56332132
174Vertebral arch anomaly (HP:0008438)1.56077114
175Upper motor neuron abnormality (HP:0002127)1.55601162
176Meckel diverticulum (HP:0002245)1.55012999
177Cafe-au-lait spot (HP:0000957)1.55010838
178Aplasia/Hypoplasia of the patella (HP:0006498)1.54572899
179Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.54368105
180Increased nuchal translucency (HP:0010880)1.54321925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.18537703
2MAP3K93.60043397
3TRIB33.36277041
4SIK23.05109109
5ERN13.00438389
6NTRK32.63566527
7BRD42.61054058
8MAP2K32.58843970
9SMG12.43156492
10BLK2.37690770
11SIK12.22311840
12MAP3K132.13204453
13MAP4K12.10454118
14RIPK42.05641740
15KSR21.96440257
16DAPK21.84450849
17NTRK21.81764638
18PAK61.75962357
19FGFR41.75671048
20MAPK151.73567390
21EPHA41.70466584
22TAOK11.61523251
23ALK1.60489772
24CSK1.54937827
25IRAK41.54024104
26STK381.51633167
27SGK31.51348236
28KSR11.43901048
29GRK51.43028170
30SGK21.42317699
31EEF2K1.41621541
32TYRO31.39436115
33GRK61.34859313
34TBK11.34315493
35MAP3K101.33572481
36MAP3K41.33446443
37SIK31.33330902
38BMPR21.30556961
39FES1.30414310
40HIPK21.26572212
41MAPK71.25361061
42MAPK131.20142470
43BTK1.19682122
44PKN21.12262849
45CDK41.11400296
46DAPK11.11389728
47EPHB11.11308448
48MARK21.10100897
49TNK21.08613181
50RAF11.06866095
51CDC71.02763533
52IKBKE1.02138540
53PRKD31.00120139
54RIPK11.00044270
55MAP3K111.00004442
56PRPF4B0.98402646
57PDPK10.96494966
58TXK0.96451019
59MINK10.95848853
60RPS6KA20.93132745
61LATS20.92937150
62TAOK20.92819998
63IKBKB0.92623926
64CAMKK10.92346850
65IRAK30.92338742
66MAP3K30.91744807
67MAP3K60.89569527
68PTK60.88837542
69SYK0.87202835
70CAMK1G0.87138012
71MARK10.86927392
72BMX0.85239211
73HCK0.82955010
74MAPK110.82156228
75CAMK40.81928944
76MAP3K120.81429297
77MAP2K60.80444433
78IRAK20.79784280
79PRKCH0.79495062
80NEK20.78618702
81TESK20.78185445
82STK110.76358090
83MAP2K40.75983174
84WNK10.75628609
85DYRK1B0.74735305
86MAPK100.74720875
87FGR0.74610000
88DYRK1A0.74191451
89LYN0.74079118
90JAK20.73952515
91SGK4940.73229312
92SGK2230.73229312
93JAK10.72832835
94MAP2K70.72649485
95MAPK120.71056136
96MAP3K140.70982186
97CHUK0.70303018
98MATK0.70231748
99RPS6KC10.70134308
100RPS6KL10.70134308
101MAP3K70.69502051
102CHEK10.68058370
103CDC42BPA0.67956935
104CDK50.66355394
105CDK20.64836902
106CHEK20.64382282
107MARK30.64145256
108CDK60.63120153
109ITK0.63056159
110ATR0.62699296
111SGK10.62566786
112NME20.61815920
113CDK80.60824039
114ARAF0.60812476
115LCK0.60707915
116TYK20.60401449
117FGFR30.59847716
118NTRK10.56119217
119MTOR0.55850071
120GSK3B0.55306384
121KIT0.54791225
122TTK0.53932910
123RPS6KA60.52742042
124MAP3K10.52513731
125JAK30.51872170
126ICK0.50951293
127CAMK1D0.50642768
128MAPK140.49487792
129PDK10.49068168
130CCNB10.48898238
131CSF1R0.48822870
132STK100.48137504
133MAP3K80.47608953
134MAPK80.46385594
135RPS6KA30.46255039
136CDK90.46156286
137AKT30.45521926
138TTN0.45112809
139PRKD20.44186097
140NEK60.42278160
141RET0.42003814
142ZAP700.41352347
143CDK10.41170297
144CAMK10.40681543
145ATM0.40543488
146LRRK20.40434497
147CDK190.35762046
148MAP2K20.34434825
149RPS6KA10.34220685
150YES10.32833649
151PASK0.32522985
152PIM10.32402991

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.48510443
2Olfactory transduction_Homo sapiens_hsa047401.94295179
3Nicotine addiction_Homo sapiens_hsa050331.80329516
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73803906
5Synaptic vesicle cycle_Homo sapiens_hsa047211.66831504
6Long-term potentiation_Homo sapiens_hsa047201.61583633
7Allograft rejection_Homo sapiens_hsa053301.57398629
8B cell receptor signaling pathway_Homo sapiens_hsa046621.56471114
9Glutamatergic synapse_Homo sapiens_hsa047241.54720382
10Staphylococcus aureus infection_Homo sapiens_hsa051501.53328859
11Morphine addiction_Homo sapiens_hsa050321.49420290
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46889839
13Circadian entrainment_Homo sapiens_hsa047131.46541039
14Graft-versus-host disease_Homo sapiens_hsa053321.43103352
15Primary immunodeficiency_Homo sapiens_hsa053401.42595212
16Autoimmune thyroid disease_Homo sapiens_hsa053201.40994742
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38701110
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.37590400
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36503709
20Sulfur relay system_Homo sapiens_hsa041221.30930924
21GnRH signaling pathway_Homo sapiens_hsa049121.26550787
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24577632
23mTOR signaling pathway_Homo sapiens_hsa041501.24054175
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.21394675
25GABAergic synapse_Homo sapiens_hsa047271.20897577
26T cell receptor signaling pathway_Homo sapiens_hsa046601.20581000
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20091390
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19847586
29Amphetamine addiction_Homo sapiens_hsa050311.18147637
30Dopaminergic synapse_Homo sapiens_hsa047281.17802575
31Fructose and mannose metabolism_Homo sapiens_hsa000511.17726511
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17697250
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17692355
34Cholinergic synapse_Homo sapiens_hsa047251.17036233
35Type II diabetes mellitus_Homo sapiens_hsa049301.16844604
36Hepatitis C_Homo sapiens_hsa051601.16636387
37Oxytocin signaling pathway_Homo sapiens_hsa049211.14265486
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.12803359
39Dorso-ventral axis formation_Homo sapiens_hsa043201.12275885
40Viral myocarditis_Homo sapiens_hsa054161.10733952
41ErbB signaling pathway_Homo sapiens_hsa040121.10228571
42Chemokine signaling pathway_Homo sapiens_hsa040621.09686177
43Non-small cell lung cancer_Homo sapiens_hsa052231.07023174
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06613578
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06177132
46Salivary secretion_Homo sapiens_hsa049701.05347601
47Glioma_Homo sapiens_hsa052141.04540264
48Hematopoietic cell lineage_Homo sapiens_hsa046401.04398233
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03697115
50Antigen processing and presentation_Homo sapiens_hsa046121.03550440
51Long-term depression_Homo sapiens_hsa047301.03441329
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03113786
53Chronic myeloid leukemia_Homo sapiens_hsa052201.02783133
54MAPK signaling pathway_Homo sapiens_hsa040101.01766141
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01717762
56Bladder cancer_Homo sapiens_hsa052191.01627383
57Choline metabolism in cancer_Homo sapiens_hsa052311.00700697
58Insulin secretion_Homo sapiens_hsa049111.00567640
59Taste transduction_Homo sapiens_hsa047420.99650209
60Osteoclast differentiation_Homo sapiens_hsa043800.99481794
61mRNA surveillance pathway_Homo sapiens_hsa030150.98984118
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.97295000
63Inositol phosphate metabolism_Homo sapiens_hsa005620.96886975
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95415973
65Asthma_Homo sapiens_hsa053100.95319415
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95115494
67Acute myeloid leukemia_Homo sapiens_hsa052210.93484793
68Colorectal cancer_Homo sapiens_hsa052100.93443591
69Endometrial cancer_Homo sapiens_hsa052130.92099457
70Epstein-Barr virus infection_Homo sapiens_hsa051690.91215704
71Oocyte meiosis_Homo sapiens_hsa041140.90963218
72Pancreatic cancer_Homo sapiens_hsa052120.90917932
73Estrogen signaling pathway_Homo sapiens_hsa049150.90156359
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89600088
75Gastric acid secretion_Homo sapiens_hsa049710.89556809
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.89079988
77Calcium signaling pathway_Homo sapiens_hsa040200.88636259
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87102772
79cAMP signaling pathway_Homo sapiens_hsa040240.86159432
80Malaria_Homo sapiens_hsa051440.84779999
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84289098
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.83996482
83VEGF signaling pathway_Homo sapiens_hsa043700.83720500
84Renin secretion_Homo sapiens_hsa049240.82993090
85Viral carcinogenesis_Homo sapiens_hsa052030.82630617
86Cocaine addiction_Homo sapiens_hsa050300.80331178
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80132569
88Endocytosis_Homo sapiens_hsa041440.79756932
89Prolactin signaling pathway_Homo sapiens_hsa049170.78779814
90Serotonergic synapse_Homo sapiens_hsa047260.78673958
91Leishmaniasis_Homo sapiens_hsa051400.77872238
92Prostate cancer_Homo sapiens_hsa052150.77203600
93Insulin resistance_Homo sapiens_hsa049310.75576217
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.75366482
95Insulin signaling pathway_Homo sapiens_hsa049100.74732643
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74366974
97Notch signaling pathway_Homo sapiens_hsa043300.73499037
98Circadian rhythm_Homo sapiens_hsa047100.73309436
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72921942
100Hepatitis B_Homo sapiens_hsa051610.71411611
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70652618
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.69719780
103Platelet activation_Homo sapiens_hsa046110.69316274
104Thyroid cancer_Homo sapiens_hsa052160.68139261
105Tuberculosis_Homo sapiens_hsa051520.67474725
106Gap junction_Homo sapiens_hsa045400.67425861
107Influenza A_Homo sapiens_hsa051640.66305871
108* Lysosome_Homo sapiens_hsa041420.65751734
109FoxO signaling pathway_Homo sapiens_hsa040680.65066328
110MicroRNAs in cancer_Homo sapiens_hsa052060.64954658
111Base excision repair_Homo sapiens_hsa034100.64946995
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64791261
113Herpes simplex infection_Homo sapiens_hsa051680.64441303
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64103006
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.63649403
116Type I diabetes mellitus_Homo sapiens_hsa049400.63458264
117TNF signaling pathway_Homo sapiens_hsa046680.63385564
118HTLV-I infection_Homo sapiens_hsa051660.63285109
119Ras signaling pathway_Homo sapiens_hsa040140.63104544
120Pertussis_Homo sapiens_hsa051330.62975385
121Fanconi anemia pathway_Homo sapiens_hsa034600.62826873
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62265296
123Rap1 signaling pathway_Homo sapiens_hsa040150.60754580
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60318934
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60244091
126Renal cell carcinoma_Homo sapiens_hsa052110.59848572
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59744422
128Cell cycle_Homo sapiens_hsa041100.59343399
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.59231042
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59213539
131Shigellosis_Homo sapiens_hsa051310.58374551
132Apoptosis_Homo sapiens_hsa042100.58054371
133African trypanosomiasis_Homo sapiens_hsa051430.57604722
134Measles_Homo sapiens_hsa051620.57115590
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.56791685
136RNA transport_Homo sapiens_hsa030130.56705793
137Legionellosis_Homo sapiens_hsa051340.56661379
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56040703
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55731939
140HIF-1 signaling pathway_Homo sapiens_hsa040660.55311747
141Toxoplasmosis_Homo sapiens_hsa051450.55282002
142Prion diseases_Homo sapiens_hsa050200.48595512
143Salmonella infection_Homo sapiens_hsa051320.47780689
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47553459

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