GGACT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.22084057
2L-phenylalanine catabolic process (GO:0006559)7.37411130
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.37411130
4regulation of DNA methylation (GO:0044030)7.24535658
5L-phenylalanine metabolic process (GO:0006558)7.13934873
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.13934873
7DNA methylation involved in gamete generation (GO:0043046)7.00374961
8regulation of meiosis I (GO:0060631)6.62837295
9regulation of female gonad development (GO:2000194)6.56406041
10aromatic amino acid family catabolic process (GO:0009074)6.50703917
11meiotic cell cycle (GO:0051321)6.22868391
12tryptophan catabolic process (GO:0006569)5.78509848
13indole-containing compound catabolic process (GO:0042436)5.78509848
14indolalkylamine catabolic process (GO:0046218)5.78509848
15regulation of acrosome reaction (GO:0060046)5.73853139
16tryptophan metabolic process (GO:0006568)5.46903689
17cysteine metabolic process (GO:0006534)5.46577704
18glyoxylate metabolic process (GO:0046487)5.34116229
19bile acid biosynthetic process (GO:0006699)5.29585744
20kynurenine metabolic process (GO:0070189)5.25611691
21female gamete generation (GO:0007292)5.12203684
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.11045581
23positive regulation of humoral immune response (GO:0002922)5.05671008
24multicellular organism reproduction (GO:0032504)4.97792019
25urea cycle (GO:0000050)4.96596818
26urea metabolic process (GO:0019627)4.96596818
27serine family amino acid catabolic process (GO:0009071)4.95298960
28synapsis (GO:0007129)4.91818580
29sulfur amino acid catabolic process (GO:0000098)4.84572074
30aromatic amino acid family metabolic process (GO:0009072)4.82157380
31male meiosis I (GO:0007141)4.73365871
32oocyte development (GO:0048599)4.73168016
33nitrogen cycle metabolic process (GO:0071941)4.64912766
34high-density lipoprotein particle remodeling (GO:0034375)4.60783527
35regulation of histone H3-K9 methylation (GO:0051570)4.57890769
36regulation of fibrinolysis (GO:0051917)4.49366526
37bile acid metabolic process (GO:0008206)4.47334416
38tyrosine metabolic process (GO:0006570)4.46000742
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.43681880
40negative regulation of fibrinolysis (GO:0051918)4.42548252
41regulation of cholesterol esterification (GO:0010872)4.41942105
42alpha-amino acid catabolic process (GO:1901606)4.37052698
43retinal cone cell development (GO:0046549)4.35745745
44amino-acid betaine metabolic process (GO:0006577)4.35489475
45cellular ketone body metabolic process (GO:0046950)4.31484491
46peptidyl-glutamic acid carboxylation (GO:0017187)4.31048251
47protein carboxylation (GO:0018214)4.31048251
48lysine catabolic process (GO:0006554)4.30542171
49lysine metabolic process (GO:0006553)4.30542171
50homocysteine metabolic process (GO:0050667)4.29848910
51amine catabolic process (GO:0009310)4.26189486
52cellular biogenic amine catabolic process (GO:0042402)4.26189486
53indolalkylamine metabolic process (GO:0006586)4.25339924
54alpha-linolenic acid metabolic process (GO:0036109)4.24314585
55cellular glucuronidation (GO:0052695)4.19068192
56coenzyme catabolic process (GO:0009109)4.15628528
57positive regulation of histone H3-K4 methylation (GO:0051571)4.15384821
58uronic acid metabolic process (GO:0006063)4.14284312
59glucuronate metabolic process (GO:0019585)4.14284312
60complement activation, alternative pathway (GO:0006957)4.12859411
61drug transmembrane transport (GO:0006855)4.11609150
62* cellular amino acid catabolic process (GO:0009063)4.08914355
63short-chain fatty acid metabolic process (GO:0046459)4.07900296
64regulation of protein activation cascade (GO:2000257)4.05553197
65phospholipid efflux (GO:0033700)4.02984300
66regulation of triglyceride catabolic process (GO:0010896)4.02926923
67aldehyde catabolic process (GO:0046185)4.02499057
68serine family amino acid metabolic process (GO:0009069)4.01877177
69reverse cholesterol transport (GO:0043691)4.00895193
70glutamate metabolic process (GO:0006536)3.99724193
71protein kinase C signaling (GO:0070528)3.99108162
72acylglycerol homeostasis (GO:0055090)3.98688593
73triglyceride homeostasis (GO:0070328)3.98688593
74meiosis I (GO:0007127)3.97860681
75plasma lipoprotein particle remodeling (GO:0034369)3.94271657
76protein-lipid complex remodeling (GO:0034368)3.94271657
77macromolecular complex remodeling (GO:0034367)3.94271657
78benzene-containing compound metabolic process (GO:0042537)3.90070531
79drug catabolic process (GO:0042737)3.84544007
80bile acid and bile salt transport (GO:0015721)3.83059857
81negative regulation of reproductive process (GO:2000242)3.82412526
82glycine metabolic process (GO:0006544)3.82257303
83urate metabolic process (GO:0046415)3.81645177
84negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.80967408
85male meiosis (GO:0007140)3.79249198
86regulation of complement activation (GO:0030449)3.75712232
87ketone body metabolic process (GO:1902224)3.73749549
88* cellular modified amino acid catabolic process (GO:0042219)3.71999556
89positive regulation of gastrulation (GO:2000543)3.70775707
90gene silencing by RNA (GO:0031047)3.70614239
91* organic acid catabolic process (GO:0016054)3.68750823
92* carboxylic acid catabolic process (GO:0046395)3.68750823
93chromosome organization involved in meiosis (GO:0070192)3.68383634
94flavonoid metabolic process (GO:0009812)3.68353247
95synaptonemal complex assembly (GO:0007130)3.67026867
96imidazole-containing compound metabolic process (GO:0052803)3.63254475
97negative regulation of sterol transport (GO:0032372)3.62085322
98negative regulation of cholesterol transport (GO:0032375)3.62085322
99arginine metabolic process (GO:0006525)3.60548557
100response to nitrosative stress (GO:0051409)3.59321087
101cofactor catabolic process (GO:0051187)3.49285977
102viral transcription (GO:0019083)3.48953733
103cholesterol efflux (GO:0033344)3.47392301
104blood coagulation, intrinsic pathway (GO:0007597)3.46967278
105low-density lipoprotein particle remodeling (GO:0034374)3.46890112
106serine family amino acid biosynthetic process (GO:0009070)3.46668732
107NAD biosynthetic process (GO:0009435)3.44863094
108ethanol oxidation (GO:0006069)3.43964121
109monocarboxylic acid catabolic process (GO:0072329)3.42629390
110regulation of retinoic acid receptor signaling pathway (GO:0048385)3.41043389
111base-excision repair, AP site formation (GO:0006285)3.40000162
112intestinal cholesterol absorption (GO:0030299)3.39828154
113exogenous drug catabolic process (GO:0042738)3.39211050
114fatty acid oxidation (GO:0019395)3.39049431
115centriole replication (GO:0007099)3.38463208
116ribosomal small subunit biogenesis (GO:0042274)3.37461645
117fatty acid beta-oxidation (GO:0006635)3.36824568
118negative regulation of histone methylation (GO:0031061)3.36145682
119lipid oxidation (GO:0034440)3.33996162
120fatty acid catabolic process (GO:0009062)3.33652128
121drug transport (GO:0015893)3.33558405
122mitotic chromosome condensation (GO:0007076)3.33031751
123plasma lipoprotein particle clearance (GO:0034381)3.32299762
124synaptonemal complex organization (GO:0070193)3.31851410
125regulation of bile acid biosynthetic process (GO:0070857)3.30996151
126plasma lipoprotein particle assembly (GO:0034377)3.30256716
127translational termination (GO:0006415)3.29319725
128fibrinolysis (GO:0042730)3.28902778
129branched-chain amino acid catabolic process (GO:0009083)3.28298669
130aspartate family amino acid catabolic process (GO:0009068)3.27371392
131acetyl-CoA metabolic process (GO:0006084)3.27249806
132drug metabolic process (GO:0017144)3.26873453
133regulation of cell maturation (GO:1903429)3.26244755
134regulation of steroid hormone secretion (GO:2000831)3.25438392
135pyridine nucleotide biosynthetic process (GO:0019363)3.25029665
136nicotinamide nucleotide biosynthetic process (GO:0019359)3.25029665
137reproduction (GO:0000003)3.19734861
138meiotic nuclear division (GO:0007126)3.16276236
139protein localization to chromosome, centromeric region (GO:0071459)3.15744688
140pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14660501
141oogenesis (GO:0048477)3.14602820
142fertilization (GO:0009566)3.14499701
143chaperone-mediated protein transport (GO:0072321)3.14328551
144attachment of spindle microtubules to kinetochore (GO:0008608)3.13151186
145DNA damage induced protein phosphorylation (GO:0006975)3.11392395
146primitive streak formation (GO:0090009)3.10048151
147positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.07625143
148positive regulation of mitotic sister chromatid separation (GO:1901970)3.07625143
149positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.07625143
150CENP-A containing nucleosome assembly (GO:0034080)3.04934314
151DNA methylation (GO:0006306)3.03394187
152DNA alkylation (GO:0006305)3.03394187
153meiotic cell cycle process (GO:1903046)3.00187611
154pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.99457090
155positive regulation of cellular amine metabolic process (GO:0033240)2.98532862
156phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.92109314
157neuron fate determination (GO:0048664)2.90637854
158glycine transport (GO:0015816)2.89367098
159regulation of hypersensitivity (GO:0002883)2.84835334
160regulation of meiosis (GO:0040020)2.81150291
161N-terminal protein amino acid acetylation (GO:0006474)2.80642422
162pyrimidine-containing compound transmembrane transport (GO:0072531)2.78895834
163positive regulation of meiosis (GO:0045836)2.78688120
164cellular response to pH (GO:0071467)2.77747476
165binding of sperm to zona pellucida (GO:0007339)2.77636685
166viral protein processing (GO:0019082)2.75089661
167viral life cycle (GO:0019058)2.74084231
168organelle membrane fusion (GO:0090174)2.73966482
169translational elongation (GO:0006414)2.73855048
170mitotic metaphase plate congression (GO:0007080)2.71963150
171chromatin remodeling at centromere (GO:0031055)2.68736896
172SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68084956
173oxidative demethylation (GO:0070989)2.65753563
174type B pancreatic cell development (GO:0003323)2.65147649
175single fertilization (GO:0007338)2.64952760
176protein deneddylation (GO:0000338)2.64179814
177proteasome assembly (GO:0043248)2.63537487
178cotranslational protein targeting to membrane (GO:0006613)2.62754879
179protein targeting to ER (GO:0045047)2.61041510
180translational initiation (GO:0006413)2.60968843
181chromatin assembly (GO:0031497)2.59259951
182immunoglobulin mediated immune response (GO:0016064)2.58939094
183positive regulation of isotype switching (GO:0045830)2.58383204
184cullin deneddylation (GO:0010388)2.56912971
185interleukin-6-mediated signaling pathway (GO:0070102)2.54798103
186negative regulation of hormone metabolic process (GO:0032351)2.54793122
187positive regulation of meiotic cell cycle (GO:0051446)2.54717496
188cellular response to arsenic-containing substance (GO:0071243)2.53337444
189termination of RNA polymerase III transcription (GO:0006386)2.51566981
190transcription elongation from RNA polymerase III promoter (GO:0006385)2.51566981
191establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48329435
192regulation of chromatin silencing (GO:0031935)2.48107333
193heme transport (GO:0015886)2.47467139
194regulation of spindle organization (GO:0090224)2.46951580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.80107857
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.31956655
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.31915742
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.25606995
5BP1_19119308_ChIP-ChIP_Hs578T_Human6.13500735
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.00038645
7LXR_22158963_ChIP-Seq_LIVER_Mouse5.54135556
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.68205908
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61020971
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.97753277
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.55551709
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.31276088
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.09688356
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.61803482
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59330233
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58501041
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35625052
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35588369
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.26513976
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.26513976
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.26513976
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26469905
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25916582
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.21948813
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17800578
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2343756
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95323612
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.89365626
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80925264
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.76685659
31FOXP3_21729870_ChIP-Seq_TREG_Human1.74705151
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.74199871
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65166781
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62911175
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61102991
36HTT_18923047_ChIP-ChIP_STHdh_Human1.59257955
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58495505
38GATA1_22025678_ChIP-Seq_K562_Human1.57058070
39VDR_23849224_ChIP-Seq_CD4+_Human1.54434689
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.48833889
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46494421
42TAF15_26573619_Chip-Seq_HEK293_Human1.43764174
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40842343
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.40075765
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37671010
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.37224171
47IRF1_19129219_ChIP-ChIP_H3396_Human1.36346500
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36051539
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34322396
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.33223341
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.33185409
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28973858
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.27834435
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26693757
55NANOG_20526341_ChIP-Seq_ESCs_Human1.26663593
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26523550
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26518890
58VDR_21846776_ChIP-Seq_THP-1_Human1.24903788
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24265058
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23908585
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23664123
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21223182
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17796404
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17003865
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16805732
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.14397181
67VDR_24763502_ChIP-Seq_THP-1_Human1.13675353
68HNF4A_19822575_ChIP-Seq_HepG2_Human1.13662111
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12897555
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12498934
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.12203250
72DCP1A_22483619_ChIP-Seq_HELA_Human1.09191652
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06357512
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06278544
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05877658
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05544026
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04525740
78MYC_18940864_ChIP-ChIP_HL60_Human1.04058719
79STAT1_20625510_ChIP-Seq_HELA_Human1.03729396
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03631197
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02278847
82MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01017377
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.00308534
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98868719
85E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98094530
86NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98085202
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97131080
88TFEB_21752829_ChIP-Seq_HELA_Human0.96675219
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94186567
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92905022
91NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91965120
92AR_20517297_ChIP-Seq_VCAP_Human0.91848177
93CDX2_20551321_ChIP-Seq_CACO-2_Human0.90569737
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89890796
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88851694
96RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88195194
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.88153958
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87158294
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87143715
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87143715
101ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86477350
102CLOCK_20551151_ChIP-Seq_293T_Human0.86416713
103STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86351511
104CTCF_21964334_Chip-Seq_Bcells_Human0.85612935
105GATA4_25053715_ChIP-Seq_YYC3_Human0.85554374
106SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84570217
107GABP_19822575_ChIP-Seq_HepG2_Human0.84310709
108AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83524318
109BCAT_22108803_ChIP-Seq_LS180_Human0.83137889
110FOXH1_21741376_ChIP-Seq_EPCs_Human0.83073594
111SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81794784
112KDM5A_27292631_Chip-Seq_BREAST_Human0.81779961
113SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81517111
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81382524
115ERG_20517297_ChIP-Seq_VCAP_Human0.81381447
116CTCF_26484167_Chip-Seq_Bcells_Mouse0.81095216
117FLI1_27457419_Chip-Seq_LIVER_Mouse0.80967992
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80847135
119NFE2_27457419_Chip-Seq_LIVER_Mouse0.80740872
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80336424
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80265950
122BCL6_27268052_Chip-Seq_Bcells_Human0.79393216
123ELK1_22589737_ChIP-Seq_MCF10A_Human0.79246478
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.78465129
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77513420
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77389619
127EGR1_19032775_ChIP-ChIP_M12_Human0.77133926
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75904150
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.75498955
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75449807
131FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75171714
132TTF2_22483619_ChIP-Seq_HELA_Human0.74164783
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74036336
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.73830863
135AR_21909140_ChIP-Seq_LNCAP_Human0.73766410
136CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73633335
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73186050
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.73026782
139SOX2_20726797_ChIP-Seq_SW620_Human0.72914971
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72492064
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70390061
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70085020
143STAT1_17558387_ChIP-Seq_HELA_Human0.68930343
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.67837316
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67772409
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67550004
147ETV2_25802403_ChIP-Seq_MESCs_Mouse0.67118204
148RUNX1_27457419_Chip-Seq_LIVER_Mouse0.65933821
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.64795525
150OCT4_21477851_ChIP-Seq_ESCs_Mouse0.64670829
151RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.64051188
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63295777
153CEBPB_22108803_ChIP-Seq_LS180_Human0.61846564
154SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60458223
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.59140743
156TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.58829218
157ESR2_21235772_ChIP-Seq_MCF-7_Human0.58230222
158PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.57365520
159ZFP57_27257070_Chip-Seq_ESCs_Mouse0.57159892
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.56701878
161SMAD1_18555785_Chip-Seq_ESCs_Mouse0.56692789
162P53_21459846_ChIP-Seq_SAOS-2_Human0.56292647
163SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55902859
164EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.55626027
165FOXA1_25552417_ChIP-Seq_VCAP_Human0.54043738
166THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.53024671
167PCGF2_27294783_Chip-Seq_NPCs_Mouse0.52705668
168Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.52657145
169ESET_19884257_ChIP-Seq_ESCs_Mouse0.52409912
170ESRRB_18555785_Chip-Seq_ESCs_Mouse0.52360893
171SOX2_19829295_ChIP-Seq_ESCs_Human0.52276221
172NANOG_19829295_ChIP-Seq_ESCs_Human0.52276221
173P53_22387025_ChIP-Seq_ESCs_Mouse0.51453703
174RARA_24833708_ChIP-Seq_LIVER_Mouse0.50945707
175EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.50920157
176GBX2_23144817_ChIP-Seq_PC3_Human0.50267830
177CDX2_19796622_ChIP-Seq_MESCs_Mouse0.49892903
178MYC_19915707_ChIP-ChIP_AK7_Human0.49808727
179CBP_21632823_ChIP-Seq_H3396_Human0.49526313
180CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.48651179
181AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.48279075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.83217206
2MP0005360_urolithiasis7.04709694
3MP0005085_abnormal_gallbladder_physiolo5.82166345
4MP0005365_abnormal_bile_salt5.39711959
5MP0008875_abnormal_xenobiotic_pharmacok4.76519363
6MP0003806_abnormal_nucleotide_metabolis3.67594384
7MP0003195_calcinosis3.54290303
8MP0003252_abnormal_bile_duct3.48117705
9MP0005332_abnormal_amino_acid3.05688788
10MP0008789_abnormal_olfactory_epithelium3.03967082
11MP0010329_abnormal_lipoprotein_level2.87889586
12MP0001666_abnormal_nutrient_absorption2.76253621
13MP0005083_abnormal_biliary_tract2.72792843
14MP0005394_taste/olfaction_phenotype2.59091106
15MP0005499_abnormal_olfactory_system2.59091106
16MP0008877_abnormal_DNA_methylation2.56062954
17MP0009840_abnormal_foam_cell2.42918055
18MP0004019_abnormal_vitamin_homeostasis2.39287594
19MP0002138_abnormal_hepatobiliary_system2.35340860
20MP0003868_abnormal_feces_composition2.27980030
21MP0003890_abnormal_embryonic-extraembry2.25703064
22MP0003693_abnormal_embryo_hatching2.15212129
23MP0003191_abnormal_cellular_cholesterol2.04320440
24MP0010030_abnormal_orbit_morphology1.93731660
25MP0002118_abnormal_lipid_homeostasis1.85660150
26MP0001764_abnormal_homeostasis1.75953981
27MP0000609_abnormal_liver_physiology1.74998906
28MP0003879_abnormal_hair_cell1.73517803
29MP0009643_abnormal_urine_homeostasis1.72202713
30MP0004043_abnormal_pH_regulation1.65850174
31MP0005084_abnormal_gallbladder_morpholo1.63151599
32MP0002234_abnormal_pharynx_morphology1.60488363
33MP0005319_abnormal_enzyme/_coenzyme1.58567924
34MP0002210_abnormal_sex_determination1.57952658
35MP0003699_abnormal_female_reproductive1.55494466
36MP0002876_abnormal_thyroid_physiology1.55394617
37MP0009379_abnormal_foot_pigmentation1.54493803
38MP0005636_abnormal_mineral_homeostasis1.49499957
39MP0003183_abnormal_peptide_metabolism1.49472864
40MP0005584_abnormal_enzyme/coenzyme_acti1.48521281
41MP0001929_abnormal_gametogenesis1.45776555
42MP0003186_abnormal_redox_activity1.44926324
43MP0005451_abnormal_body_composition1.38867858
44MP0005408_hypopigmentation1.38783567
45MP0002653_abnormal_ependyma_morphology1.37052940
46MP0009697_abnormal_copulation1.37052268
47MP0003077_abnormal_cell_cycle1.32414781
48MP0005410_abnormal_fertilization1.31799963
49MP0004381_abnormal_hair_follicle1.26684004
50MP0003950_abnormal_plasma_membrane1.26632706
51MP0003646_muscle_fatigue1.19824979
52MP0008057_abnormal_DNA_replication1.19771788
53MP0002163_abnormal_gland_morphology1.19064558
54MP0003300_gastrointestinal_ulcer1.18717863
55MP0006036_abnormal_mitochondrial_physio1.18699730
56MP0008932_abnormal_embryonic_tissue1.15867291
57MP0000653_abnormal_sex_gland1.14612846
58MP0002160_abnormal_reproductive_system1.13048824
59MP0005647_abnormal_sex_gland1.11685718
60MP0003724_increased_susceptibility_to1.09836816
61MP0005220_abnormal_exocrine_pancreas1.09527685
62MP0010234_abnormal_vibrissa_follicle1.06529511
63MP0002078_abnormal_glucose_homeostasis1.03029128
64MP0001293_anophthalmia1.02083438
65MP0001119_abnormal_female_reproductive1.01063497
66MP0009764_decreased_sensitivity_to1.00268502
67MP0002161_abnormal_fertility/fecundity0.99734138
68MP0003656_abnormal_erythrocyte_physiolo0.98104347
69MP0003011_delayed_dark_adaptation0.96457539
70MP0009642_abnormal_blood_homeostasis0.95586581
71MP0001765_abnormal_ion_homeostasis0.94404020
72MP0003111_abnormal_nucleus_morphology0.93053728
73MP0005389_reproductive_system_phenotype0.92498000
74MP0001756_abnormal_urination0.91476246
75MP0005535_abnormal_body_temperature0.90951456
76MP0000678_abnormal_parathyroid_gland0.90436843
77MP0008469_abnormal_protein_level0.89578697
78MP0001145_abnormal_male_reproductive0.89201080
79MP0000598_abnormal_liver_morphology0.85904682
80MP0008058_abnormal_DNA_repair0.85783770
81MP0001661_extended_life_span0.85148652
82MP0001730_embryonic_growth_arrest0.83933781
83MP0001944_abnormal_pancreas_morphology0.83430456
84MP0001324_abnormal_eye_pigmentation0.83414665
85MP0009765_abnormal_xenobiotic_induced0.82527919
86MP0000372_irregular_coat_pigmentation0.82376403
87MP0009333_abnormal_splenocyte_physiolog0.81930674
88MP0004957_abnormal_blastocyst_morpholog0.80713083
89MP0000685_abnormal_immune_system0.79732604
90MP0001881_abnormal_mammary_gland0.78814189
91MP0009763_increased_sensitivity_to0.77849614
92MP0000358_abnormal_cell_content/0.76021881
93MP0002127_abnormal_cardiovascular_syste0.73157103
94MP0002928_abnormal_bile_duct0.72338542
95MP0002693_abnormal_pancreas_physiology0.71082685
96MP0000762_abnormal_tongue_morphology0.69909942
97MP0006035_abnormal_mitochondrial_morpho0.69765439
98MP0005670_abnormal_white_adipose0.69752096
99MP0005379_endocrine/exocrine_gland_phen0.69745862
100MP0002837_dystrophic_cardiac_calcinosis0.69249366
101MP0002136_abnormal_kidney_physiology0.69006274
102MP0005376_homeostasis/metabolism_phenot0.66849750
103MP0005310_abnormal_salivary_gland0.66432767
104MP0010307_abnormal_tumor_latency0.65235820
105MP0005501_abnormal_skin_physiology0.65179065
106MP0002148_abnormal_hypersensitivity_rea0.65076367
107MP0000049_abnormal_middle_ear0.64949251
108MP0003941_abnormal_skin_development0.64794477
109MP0002277_abnormal_respiratory_mucosa0.64785412
110MP0009785_altered_susceptibility_to0.64747010
111MP0010368_abnormal_lymphatic_system0.64333341
112MP0003953_abnormal_hormone_level0.64167162
113MP0005174_abnormal_tail_pigmentation0.64026785
114MP0002009_preneoplasia0.63999826
115MP0001790_abnormal_immune_system0.62548445
116MP0005387_immune_system_phenotype0.62548445
117MP0003638_abnormal_response/metabolism_0.62545084
118MP0000538_abnormal_urinary_bladder0.62077169
119MP0002419_abnormal_innate_immunity0.61874029
120MP0001800_abnormal_humoral_immune0.61490694
121MP0005334_abnormal_fat_pad0.61359800
122MP0004233_abnormal_muscle_weight0.61065988
123MP0001835_abnormal_antigen_presentation0.59907445
124MP0000604_amyloidosis0.59904997
125MP0002452_abnormal_antigen_presenting0.59654937
126MP0002723_abnormal_immune_serum0.59033423
127MP0000631_abnormal_neuroendocrine_gland0.58500838
128MP0005058_abnormal_lysosome_morphology0.58493800
129MP0008004_abnormal_stomach_pH0.57719821
130MP0003698_abnormal_male_reproductive0.57698366
131MP0006276_abnormal_autonomic_nervous0.57458662
132MP0002971_abnormal_brown_adipose0.55383750
133MP0000230_abnormal_systemic_arterial0.55252726
134MP0000639_abnormal_adrenal_gland0.54790151
135MP0003718_maternal_effect0.53847843
136MP0005395_other_phenotype0.53327669
137MP0005075_abnormal_melanosome_morpholog0.51767003
138MP0002132_abnormal_respiratory_system0.50418516
139MP0004142_abnormal_muscle_tone0.49365341
140MP0005464_abnormal_platelet_physiology0.48273156
141MP0004147_increased_porphyrin_level0.46765547
142MP0003959_abnormal_lean_body0.46195980
143MP0003136_yellow_coat_color0.46138355
144MP0005448_abnormal_energy_balance0.45232224
145MP0002796_impaired_skin_barrier0.43348783
146MP0002254_reproductive_system_inflammat0.42876735
147MP0008874_decreased_physiological_sensi0.41843676
148MP0004782_abnormal_surfactant_physiolog0.39859544
149MP0002638_abnormal_pupillary_reflex0.39718346
150MP0002822_catalepsy0.39526889
151MP0005646_abnormal_pituitary_gland0.38839045
152MP0005266_abnormal_metabolism0.38828021
153MP0002168_other_aberrant_phenotype0.37590166
154MP0003690_abnormal_glial_cell0.36438880
155MP0001845_abnormal_inflammatory_respons0.36402649
156MP0006292_abnormal_olfactory_placode0.35639592
157MP0003329_amyloid_beta_deposits0.34847177
158MP0001986_abnormal_taste_sensitivity0.33677888
159MP0008872_abnormal_physiological_respon0.32929592
160MP0001664_abnormal_digestion0.32101722
161MP0000566_synostosis0.30694522
162MP0006082_CNS_inflammation0.30339596
163MP0010386_abnormal_urinary_bladder0.29998271

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.01710518
2Intrahepatic cholestasis (HP:0001406)6.13830277
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.64809673
4Prolonged partial thromboplastin time (HP:0003645)5.52486921
5Deep venous thrombosis (HP:0002625)5.10189080
6Hypobetalipoproteinemia (HP:0003563)5.03690857
7Xanthomatosis (HP:0000991)4.97642878
8Osteomalacia (HP:0002749)4.96311105
9Hyperglycinemia (HP:0002154)4.56993186
10Hyperglycinuria (HP:0003108)4.28051159
11Hyperlipoproteinemia (HP:0010980)4.24421172
12Azoospermia (HP:0000027)4.19470132
13Ketosis (HP:0001946)4.09449744
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.07587167
15Hypoglycemic coma (HP:0001325)4.07447894
16Hyperammonemia (HP:0001987)4.03139988
17Joint hemorrhage (HP:0005261)3.95565426
18Abnormality of serine family amino acid metabolism (HP:0010894)3.95021715
19Abnormality of glycine metabolism (HP:0010895)3.95021715
20Complement deficiency (HP:0004431)3.82670943
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.76060153
22Conjugated hyperbilirubinemia (HP:0002908)3.70773721
23Fat malabsorption (HP:0002630)3.66779084
24Abnormality of the common coagulation pathway (HP:0010990)3.63142282
25Male infertility (HP:0003251)3.60901622
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.59875873
27Hypolipoproteinemia (HP:0010981)3.53281163
28Abnormality of methionine metabolism (HP:0010901)3.51626180
29Hypokinesia (HP:0002375)3.49615360
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.49122385
31Abnormal spermatogenesis (HP:0008669)3.48916679
32Ketoacidosis (HP:0001993)3.44935863
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.37974710
34Epidermoid cyst (HP:0200040)3.31748929
35Abnormality of the intrinsic pathway (HP:0010989)3.30932717
36Cholecystitis (HP:0001082)3.27880518
37Abnormal gallbladder physiology (HP:0012438)3.27880518
38Abnormality of fatty-acid metabolism (HP:0004359)3.27055770
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.25072844
40Gout (HP:0001997)3.18625241
41Loss of speech (HP:0002371)3.13275574
42Abnormality of abdominal situs (HP:0011620)3.09281900
43Abdominal situs inversus (HP:0003363)3.09281900
44Premature ovarian failure (HP:0008209)3.07426290
45Abnormality of pyrimidine metabolism (HP:0004353)3.06084311
46Lethargy (HP:0001254)3.03502962
47Hyperbilirubinemia (HP:0002904)3.03189514
48Hypoglycemic seizures (HP:0002173)3.02964035
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02468379
50Abnormality of serum amino acid levels (HP:0003112)3.00574873
51Alkalosis (HP:0001948)2.99585351
52Metaphyseal irregularity (HP:0003025)2.97801634
53Abnormality of nucleobase metabolism (HP:0010932)2.97556388
54Cerebral edema (HP:0002181)2.97414377
55Late onset (HP:0003584)2.95923346
56Generalized aminoaciduria (HP:0002909)2.95495051
57Abnormality of purine metabolism (HP:0004352)2.93292427
58Metabolic acidosis (HP:0001942)2.89967163
59Dicarboxylic aciduria (HP:0003215)2.87416791
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87416791
61Delayed CNS myelination (HP:0002188)2.86432936
62Hypoalphalipoproteinemia (HP:0003233)2.83793740
63Facial hemangioma (HP:0000329)2.77666119
64Anterior segment dysgenesis (HP:0007700)2.76216916
65Glycosuria (HP:0003076)2.74804512
66Abnormality of urine glucose concentration (HP:0011016)2.74804512
67Hyperinsulinemic hypoglycemia (HP:0000825)2.74015545
68Steatorrhea (HP:0002570)2.73386400
69Aplastic anemia (HP:0001915)2.73043742
70Renal Fanconi syndrome (HP:0001994)2.72166670
71Hypergonadotropic hypogonadism (HP:0000815)2.70432986
72Impulsivity (HP:0100710)2.69495049
73Abnormality of complement system (HP:0005339)2.67161700
74Symptomatic seizures (HP:0011145)2.52732662
75Irritability (HP:0000737)2.51090533
76Vascular calcification (HP:0004934)2.45250214
77Hypercholesterolemia (HP:0003124)2.45172994
78Acute encephalopathy (HP:0006846)2.44818301
79Conjunctival telangiectasia (HP:0000524)2.43726580
80Methylmalonic acidemia (HP:0002912)2.42880857
81Lip pit (HP:0100267)2.42225113
82Hyperactive renin-angiotensin system (HP:0000841)2.41726984
83Vomiting (HP:0002013)2.40698925
84Limb hypertonia (HP:0002509)2.40253989
85Supernumerary spleens (HP:0009799)2.39670984
86Abnormal number of erythroid precursors (HP:0012131)2.36972344
87Malnutrition (HP:0004395)2.34826058
88Nausea (HP:0002018)2.34362202
89Neonatal onset (HP:0003623)2.34318227
90Pancreatitis (HP:0001733)2.33211260
91Renal tubular dysfunction (HP:0000124)2.31777188
92Hypoplasia of the fovea (HP:0007750)2.27969839
93Aplasia/Hypoplasia of the fovea (HP:0008060)2.27969839
94Proximal tubulopathy (HP:0000114)2.27879209
95Hyperphosphaturia (HP:0003109)2.26289567
96Glomerulonephritis (HP:0000099)2.25107476
97Abnormality of cells of the erythroid lineage (HP:0012130)2.24302747
98Hepatic necrosis (HP:0002605)2.23825645
99Spontaneous abortion (HP:0005268)2.23515891
1003-Methylglutaconic aciduria (HP:0003535)2.23033035
101Type I transferrin isoform profile (HP:0003642)2.22782599
102Papillary thyroid carcinoma (HP:0002895)2.21694985
103Acanthocytosis (HP:0001927)2.21258667
104Respiratory difficulties (HP:0002880)2.18680290
105Hyperuricemia (HP:0002149)2.15276275
106Increased purine levels (HP:0004368)2.15276275
107Abnormality of the vasculature of the conjunctiva (HP:0008054)2.13539777
108Rickets (HP:0002748)2.13016193
109Abnormal biliary tract physiology (HP:0012439)2.12507081
110Bile duct proliferation (HP:0001408)2.12507081
111Hepatocellular carcinoma (HP:0001402)2.11696357
112Prolonged neonatal jaundice (HP:0006579)2.11172494
113Abnormality of renal resorption (HP:0011038)2.09869000
114Opisthotonus (HP:0002179)2.07116064
115Menorrhagia (HP:0000132)2.06655560
116Cardiovascular calcification (HP:0011915)2.05707596
117Elevated alkaline phosphatase (HP:0003155)2.05293373
118Congenital ichthyosiform erythroderma (HP:0007431)2.04503636
119Septo-optic dysplasia (HP:0100842)2.04300355
120Chromsome breakage (HP:0040012)2.03957406
121Hypophosphatemic rickets (HP:0004912)2.02387421
122Enlarged kidneys (HP:0000105)2.02001625
123Brushfield spots (HP:0001088)2.01351626
124Metabolic alkalosis (HP:0200114)1.99081266
125Stomatitis (HP:0010280)1.98810114
126Abnormality of alkaline phosphatase activity (HP:0004379)1.98505093
127Increased hepatocellular lipid droplets (HP:0006565)1.97796529
128Skin nodule (HP:0200036)1.96806409
129Macrocytic anemia (HP:0001972)1.96180614
130Sparse eyelashes (HP:0000653)1.95980512
131IgA deficiency (HP:0002720)1.94707112
132Abnormality of macrophages (HP:0004311)1.94477490
133Myocardial infarction (HP:0001658)1.93642834
134Acute hepatic failure (HP:0006554)1.91591782
135Gonadotropin excess (HP:0000837)1.90997409
136Abnormal urine phosphate concentration (HP:0012599)1.90419656
137Lower limb hyperreflexia (HP:0002395)1.90236324
138Increased circulating renin level (HP:0000848)1.89531080
139Infertility (HP:0000789)1.89445978
140Vacuolated lymphocytes (HP:0001922)1.88973335
141Hypotrichosis (HP:0001006)1.88930283
142Severe visual impairment (HP:0001141)1.88442258
143Sensorimotor neuropathy (HP:0007141)1.88028248
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86729660
145Abnormality of proline metabolism (HP:0010907)1.86352620
146Hydroxyprolinuria (HP:0003080)1.86352620
147Abnormality of vitamin metabolism (HP:0100508)1.85105109
148Abnormality of the fovea (HP:0000493)1.84994175
149Anhidrosis (HP:0000970)1.84739447
150Hypophosphatemia (HP:0002148)1.84519088
151Cleft eyelid (HP:0000625)1.84001146
152IgM deficiency (HP:0002850)1.83791000
153Abnormal enzyme/coenzyme activity (HP:0012379)1.83675398
154Fair hair (HP:0002286)1.83564666
155Elevated hepatic transaminases (HP:0002910)1.83005238
156Abnormal gallbladder morphology (HP:0012437)1.82944493
157Amyloidosis (HP:0011034)1.82765323
158Renal cortical cysts (HP:0000803)1.82653496
159Abnormality of chloride homeostasis (HP:0011422)1.82562993
160Recurrent bacterial skin infections (HP:0005406)1.81773151
161Methylmalonic aciduria (HP:0012120)1.81368179
162Abnormality of renin-angiotensin system (HP:0000847)1.80074970
163Recurrent abscess formation (HP:0002722)1.79208071
164Reticulocytopenia (HP:0001896)1.79062632
165Systemic lupus erythematosus (HP:0002725)1.79001814
166Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78885158
167Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78885158
168Reduced antithrombin III activity (HP:0001976)1.78509478
169Recurrent gram-negative bacterial infections (HP:0005420)1.77981749
170Abnormality of the phalanges of the hallux (HP:0010057)1.77198674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.60733982
2ARAF5.40630211
3MAP3K134.86275209
4MAP3K94.10754951
5INSRR3.46100698
6STK243.39098470
7MAPK153.19164801
8CASK2.73479216
9WNK42.66553191
10FRK2.63362365
11BRAF2.58140911
12TAOK32.53231189
13FGFR42.31766708
14SIK12.25632415
15ZAK2.23078495
16PRKD22.22223117
17TTK2.17467679
18ERN12.16595749
19MAP4K22.13270666
20IRAK32.09336450
21BUB12.08528532
22MOS2.06540321
23NME22.05369344
24STK381.90481564
25MELK1.81629335
26PIK3CG1.81581758
27CDK91.80821750
28MUSK1.79366266
29TGFBR11.74665531
30KSR21.73315585
31MET1.72699227
32NLK1.62714431
33MST1R1.59987774
34IRAK11.55173352
35AURKA1.53636322
36NUAK11.52738348
37RAF11.47974351
38WNK31.47475529
39ERBB41.47332344
40PINK11.46495790
41LATS21.46243481
42STK31.40763790
43NEK61.38151913
44LATS11.35807039
45VRK21.34211460
46IRAK21.32961745
47OXSR11.30366886
48GRK61.27749796
49STK161.26731498
50CDK71.25055550
51STK391.21981445
52ACVR1B1.21709643
53PBK1.20570940
54IKBKE1.20039792
55HIPK21.18897559
56FLT31.12505602
57MAPK111.09948390
58NEK91.09672296
59EPHB21.08679133
60CSF1R1.05750860
61KIT1.05619095
62MAP3K141.05057305
63MAP2K21.04782418
64PRKCI1.03920276
65TXK1.02516172
66CDK80.99335489
67VRK10.97365004
68ADRBK20.95832986
69GRK70.95704167
70MAP2K40.93398544
71MAP3K80.92954665
72JAK20.91766683
73TBK10.91663285
74NEK20.90364004
75MST40.87413507
76TNIK0.86545109
77EIF2AK30.85718120
78DYRK1B0.84155701
79TYK20.84133135
80LMTK20.83491454
81IRAK40.82588545
82TIE10.82514290
83YES10.82450676
84KSR10.82361229
85CAMK2G0.82274654
86PASK0.81458999
87PRKAA20.80891613
88CAMKK20.78797520
89EPHA30.77588253
90MAP2K60.74700948
91ABL20.72698452
92PLK10.72341434
93SGK20.71536644
94SGK2230.71407213
95SGK4940.71407213
96MAP2K70.71275174
97MAPK40.69545519
98MAP3K30.66797049
99MAP3K10.66563589
100GRK10.66058366
101CDC70.64984670
102STK110.63998843
103MARK30.63651902
104JAK10.63027720
105TAOK20.60435444
106MAPK120.60402790
107KDR0.60353740
108MAP3K20.58410106
109STK38L0.58104580
110CSK0.57549787
111GSK3A0.57206587
112CSNK1G10.57041542
113BMPR20.56668095
114EPHB10.56411926
115LRRK20.56411536
116CDK120.56048879
117PRKG20.55872365
118MATK0.55424653
119TEC0.55421939
120RPS6KA40.54901968
121PRKCQ0.54374614
122CHEK10.54191276
123PRKACG0.54166214
124PRKD30.53818069
125PRPF4B0.52684200
126MAP3K100.52470739
127PDPK10.50451863
128TNK20.50409847
129CAMK2B0.49055466
130GRK50.48516064
131TLK10.47626957
132CDK190.46939703
133ZAP700.44975667
134PRKACA0.44264562
135CAMK1G0.42276377
136PDK10.41904295
137PRKCG0.41866087
138IKBKB0.41012303
139PIM20.40008620
140MAPKAPK30.39606291
141TESK20.39335918
142CAMK1D0.38874874
143BLK0.38325321
144SGK30.38253945
145BTK0.38061419
146PRKG10.37775514
147PAK10.37233516
148PTK20.36934803
149JAK30.36393861
150MAPKAPK50.35528948
151BMPR1B0.35295952
152CHEK20.34637935
153PRKCA0.34582069
154PRKAA10.33968956
155CAMK2A0.33462870
156MAP4K10.33037799
157UHMK10.32769003
158DAPK20.32637418
159AURKB0.32352981
160DYRK30.31859279
161PIM10.31712998
162DMPK0.31565413
163PRKD10.31355836
164STK40.29895303
165FGR0.28761541
166TGFBR20.28058444

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.32338940
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.97604524
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29648190
4Nitrogen metabolism_Homo sapiens_hsa009102.83346342
5Tryptophan metabolism_Homo sapiens_hsa003802.69211533
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68469884
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59211968
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.58201161
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57479175
10Arginine biosynthesis_Homo sapiens_hsa002202.55135146
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45405315
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.42484844
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41853834
14Base excision repair_Homo sapiens_hsa034102.41223918
15Fatty acid degradation_Homo sapiens_hsa000712.34763292
16Butanoate metabolism_Homo sapiens_hsa006502.30798954
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.26906973
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.22115313
19Peroxisome_Homo sapiens_hsa041462.20627057
20Complement and coagulation cascades_Homo sapiens_hsa046102.16379419
21Sulfur metabolism_Homo sapiens_hsa009202.12768979
22RNA polymerase_Homo sapiens_hsa030202.11845827
23Histidine metabolism_Homo sapiens_hsa003402.10539185
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00998244
25Propanoate metabolism_Homo sapiens_hsa006401.98963172
26Cell cycle_Homo sapiens_hsa041101.98604551
27Chemical carcinogenesis_Homo sapiens_hsa052041.95565622
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.90527255
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87348764
30RNA degradation_Homo sapiens_hsa030181.75930640
31beta-Alanine metabolism_Homo sapiens_hsa004101.71481986
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68907956
33Fatty acid elongation_Homo sapiens_hsa000621.67840531
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.63772917
35Fatty acid metabolism_Homo sapiens_hsa012121.61565418
36Retinol metabolism_Homo sapiens_hsa008301.59077713
37Folate biosynthesis_Homo sapiens_hsa007901.58288173
38Phenylalanine metabolism_Homo sapiens_hsa003601.57741393
39PPAR signaling pathway_Homo sapiens_hsa033201.56654211
40Homologous recombination_Homo sapiens_hsa034401.55128366
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54554674
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51601130
43Selenocompound metabolism_Homo sapiens_hsa004501.51156752
44Ovarian steroidogenesis_Homo sapiens_hsa049131.50434811
45Tyrosine metabolism_Homo sapiens_hsa003501.46204399
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44792650
47Caffeine metabolism_Homo sapiens_hsa002321.44082589
48Dorso-ventral axis formation_Homo sapiens_hsa043201.43827147
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.40315347
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38012165
51Pyruvate metabolism_Homo sapiens_hsa006201.36927738
52Bile secretion_Homo sapiens_hsa049761.36840351
53Mismatch repair_Homo sapiens_hsa034301.31449611
54Starch and sucrose metabolism_Homo sapiens_hsa005001.30989458
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27389803
56Fat digestion and absorption_Homo sapiens_hsa049751.24124444
57Staphylococcus aureus infection_Homo sapiens_hsa051501.18014217
58Asthma_Homo sapiens_hsa053101.16559806
59Vitamin digestion and absorption_Homo sapiens_hsa049771.12099565
60Steroid biosynthesis_Homo sapiens_hsa001001.12025213
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.11804026
62Sulfur relay system_Homo sapiens_hsa041221.10284187
63Intestinal immune network for IgA production_Homo sapiens_hsa046721.10150031
64DNA replication_Homo sapiens_hsa030301.09168714
65ABC transporters_Homo sapiens_hsa020101.08250039
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07468303
67Glycosaminoglycan degradation_Homo sapiens_hsa005311.05401557
68Arginine and proline metabolism_Homo sapiens_hsa003301.03672768
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01919864
70p53 signaling pathway_Homo sapiens_hsa041151.00183014
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99440207
72Pyrimidine metabolism_Homo sapiens_hsa002400.97349998
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95491364
74Allograft rejection_Homo sapiens_hsa053300.95450055
75Nucleotide excision repair_Homo sapiens_hsa034200.94631577
76Protein export_Homo sapiens_hsa030600.91562474
77Herpes simplex infection_Homo sapiens_hsa051680.91499697
78Thyroid cancer_Homo sapiens_hsa052160.89977059
79Carbon metabolism_Homo sapiens_hsa012000.89062820
80Glutathione metabolism_Homo sapiens_hsa004800.88763510
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85855558
82Autoimmune thyroid disease_Homo sapiens_hsa053200.85030637
83Oocyte meiosis_Homo sapiens_hsa041140.81955588
84RNA transport_Homo sapiens_hsa030130.79380385
85Biosynthesis of amino acids_Homo sapiens_hsa012300.77910087
86Fanconi anemia pathway_Homo sapiens_hsa034600.74497574
87Oxidative phosphorylation_Homo sapiens_hsa001900.73779138
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73477515
89Glycerolipid metabolism_Homo sapiens_hsa005610.68225247
90Metabolic pathways_Homo sapiens_hsa011000.67511826
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67457831
92Graft-versus-host disease_Homo sapiens_hsa053320.61975892
93Notch signaling pathway_Homo sapiens_hsa043300.60732153
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54720073
95Vitamin B6 metabolism_Homo sapiens_hsa007500.54176495
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53430025
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50097706
98Lysine degradation_Homo sapiens_hsa003100.48724262
99Parkinsons disease_Homo sapiens_hsa050120.47650591
100Pentose phosphate pathway_Homo sapiens_hsa000300.47101679
101Proteasome_Homo sapiens_hsa030500.46288514
102Systemic lupus erythematosus_Homo sapiens_hsa053220.45238053
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43875332
104Purine metabolism_Homo sapiens_hsa002300.42970939
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42746885
106Rheumatoid arthritis_Homo sapiens_hsa053230.42690406
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42323671
108Leishmaniasis_Homo sapiens_hsa051400.41778771
109One carbon pool by folate_Homo sapiens_hsa006700.41375013
110Linoleic acid metabolism_Homo sapiens_hsa005910.41261213
111HTLV-I infection_Homo sapiens_hsa051660.37433419
112Spliceosome_Homo sapiens_hsa030400.36351670
113Epstein-Barr virus infection_Homo sapiens_hsa051690.35376988
114TGF-beta signaling pathway_Homo sapiens_hsa043500.35221720
115Phototransduction_Homo sapiens_hsa047440.35186194
116Alzheimers disease_Homo sapiens_hsa050100.34822860
117Osteoclast differentiation_Homo sapiens_hsa043800.34819080
118Viral carcinogenesis_Homo sapiens_hsa052030.33650748
119Antigen processing and presentation_Homo sapiens_hsa046120.33457970
120Renin-angiotensin system_Homo sapiens_hsa046140.32602170
121Hematopoietic cell lineage_Homo sapiens_hsa046400.32012697
122Prion diseases_Homo sapiens_hsa050200.31414029
123Other glycan degradation_Homo sapiens_hsa005110.31214897
124Phagosome_Homo sapiens_hsa041450.31010664
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30330896
126Galactose metabolism_Homo sapiens_hsa000520.29614349
127Fructose and mannose metabolism_Homo sapiens_hsa000510.26564088
128Fatty acid biosynthesis_Homo sapiens_hsa000610.23390975
129Arachidonic acid metabolism_Homo sapiens_hsa005900.22846384
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.22190540
131Ether lipid metabolism_Homo sapiens_hsa005650.21384499
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19731729
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17676966
134Huntingtons disease_Homo sapiens_hsa050160.12018731
135Regulation of autophagy_Homo sapiens_hsa041400.10547094
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08407072
137Insulin resistance_Homo sapiens_hsa049310.04541129
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03509122
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.01934773
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.01122729
141Glucagon signaling pathway_Homo sapiens_hsa049220.01109429
142Mineral absorption_Homo sapiens_hsa049780.00895855
143Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0484914
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0466774
145Protein digestion and absorption_Homo sapiens_hsa04974-0.0426800
146Sphingolipid metabolism_Homo sapiens_hsa00600-0.0363584
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0146017
148Pancreatic secretion_Homo sapiens_hsa04972-0.0118970
149Ribosome_Homo sapiens_hsa03010-0.0100127

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