GGCT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.93027819
2establishment of skin barrier (GO:0061436)8.40071527
3long-chain fatty acid biosynthetic process (GO:0042759)7.79336546
4axon ensheathment in central nervous system (GO:0032291)7.28288384
5central nervous system myelination (GO:0022010)7.28288384
6regulation of water loss via skin (GO:0033561)7.03440048
7glycerophospholipid catabolic process (GO:0046475)5.22562360
8CENP-A containing nucleosome assembly (GO:0034080)4.93646400
9chromatin remodeling at centromere (GO:0031055)4.90793425
10chaperone-mediated protein transport (GO:0072321)4.81580840
11keratinization (GO:0031424)4.75495447
12establishment of integrated proviral latency (GO:0075713)4.74566270
13myelination (GO:0042552)4.65322417
14ensheathment of neurons (GO:0007272)4.64307326
15axon ensheathment (GO:0008366)4.64307326
16DNA strand elongation involved in DNA replication (GO:0006271)4.60722627
17DNA replication checkpoint (GO:0000076)4.59873433
18sphingosine metabolic process (GO:0006670)4.56197573
19cholesterol biosynthetic process (GO:0006695)4.52452220
20telomere maintenance via semi-conservative replication (GO:0032201)4.44706918
21DNA strand elongation (GO:0022616)4.42472324
22multicellular organismal water homeostasis (GO:0050891)4.40151184
23sphingoid metabolic process (GO:0046519)4.36372530
24desmosome organization (GO:0002934)4.34280737
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.23965479
26purine nucleobase biosynthetic process (GO:0009113)4.21734956
27histone exchange (GO:0043486)4.07214241
28diol metabolic process (GO:0034311)4.06558208
29long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.06048338
30ribosomal large subunit biogenesis (GO:0042273)4.05951304
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.03124763
32negative regulation of execution phase of apoptosis (GO:1900118)3.99780611
33water homeostasis (GO:0030104)3.99396849
34sterol biosynthetic process (GO:0016126)3.97652038
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.96308553
36DNA replication-independent nucleosome assembly (GO:0006336)3.95338691
37DNA replication-independent nucleosome organization (GO:0034724)3.95338691
38regulation of cell proliferation involved in kidney development (GO:1901722)3.93739414
39mitotic metaphase plate congression (GO:0007080)3.91509008
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.88953552
41negative regulation of ligase activity (GO:0051352)3.88567947
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.88567947
43phosphatidylinositol acyl-chain remodeling (GO:0036149)3.87196366
44nucleobase biosynthetic process (GO:0046112)3.86956579
45protein neddylation (GO:0045116)3.85650558
46response to redox state (GO:0051775)3.85140931
47IMP biosynthetic process (GO:0006188)3.84818409
48telomere maintenance via recombination (GO:0000722)3.84592092
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.83884836
50ribosome assembly (GO:0042255)3.83656874
51detection of bacterium (GO:0016045)3.76313776
52mitotic recombination (GO:0006312)3.75337122
53long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.74891147
54protein localization to kinetochore (GO:0034501)3.72031807
55establishment of viral latency (GO:0019043)3.71557721
56ribosomal small subunit assembly (GO:0000028)3.65696564
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.64183507
58regulation of transforming growth factor beta1 production (GO:0032908)3.57621626
59formation of translation preinitiation complex (GO:0001731)3.57179963
60isoprenoid biosynthetic process (GO:0008299)3.56951006
61maturation of SSU-rRNA (GO:0030490)3.56557654
62negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.54273071
63metaphase plate congression (GO:0051310)3.49296129
64IMP metabolic process (GO:0046040)3.49049217
65regulation of cellular amino acid metabolic process (GO:0006521)3.47327253
66termination of RNA polymerase III transcription (GO:0006386)3.45708567
67transcription elongation from RNA polymerase III promoter (GO:0006385)3.45708567
68phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.45589094
69keratinocyte differentiation (GO:0030216)3.44963285
70negative regulation of neurotransmitter transport (GO:0051589)3.43968146
71fatty-acyl-CoA metabolic process (GO:0035337)3.43759493
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43721899
73positive regulation of glomerulus development (GO:0090193)3.43278967
74rRNA modification (GO:0000154)3.40122157
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.40054357
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.40054357
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.40054357
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.38776550
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.38735252
80regulation of meiosis (GO:0040020)3.38195074
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38171904
82GPI anchor biosynthetic process (GO:0006506)3.38104041
83spliceosomal snRNP assembly (GO:0000387)3.37711933
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.37165351
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.37165351
86substantia nigra development (GO:0021762)3.36890431
87piRNA metabolic process (GO:0034587)3.36432374
88cotranslational protein targeting to membrane (GO:0006613)3.34889950
89DNA ligation (GO:0006266)3.33728596
90kinetochore organization (GO:0051383)3.33485997
91telomere maintenance via telomere lengthening (GO:0010833)3.33484758
92positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.33201000
93signal transduction involved in DNA damage checkpoint (GO:0072422)3.32609564
94signal transduction involved in DNA integrity checkpoint (GO:0072401)3.32609564
95oxidative phosphorylation (GO:0006119)3.32592294
96viral transcription (GO:0019083)3.32589730
97preassembly of GPI anchor in ER membrane (GO:0016254)3.32414231
98translational termination (GO:0006415)3.31510810
99negative regulation of neurotransmitter secretion (GO:0046929)3.30512861
100ribosomal small subunit biogenesis (GO:0042274)3.29772516
101protein targeting to ER (GO:0045047)3.29244750
102cullin deneddylation (GO:0010388)3.27843675
103regulation of mitochondrial translation (GO:0070129)3.27075055
104ATP synthesis coupled proton transport (GO:0015986)3.26831651
105energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26831651
106mitotic sister chromatid segregation (GO:0000070)3.26422784
107signal transduction involved in cell cycle checkpoint (GO:0072395)3.26342027
108DNA double-strand break processing (GO:0000729)3.24001417
109translation (GO:0006412)3.23086815
110phosphatidylcholine acyl-chain remodeling (GO:0036151)3.20579568
111fatty-acyl-CoA biosynthetic process (GO:0046949)3.20111622
112DNA catabolic process, exonucleolytic (GO:0000738)3.20007991
113DNA unwinding involved in DNA replication (GO:0006268)3.19856272
114positive regulation of ligase activity (GO:0051351)3.18360224
115DNA replication-dependent nucleosome assembly (GO:0006335)3.17569566
116DNA replication-dependent nucleosome organization (GO:0034723)3.17569566
117establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17358704
118regulation of helicase activity (GO:0051095)3.16938273
119translational initiation (GO:0006413)3.16060179
120regulation of ubiquitin-protein transferase activity (GO:0051438)3.16031049
121G1/S transition of mitotic cell cycle (GO:0000082)3.15168969
122cell cycle G1/S phase transition (GO:0044843)3.15168969
123ribonucleoprotein complex biogenesis (GO:0022613)3.14815444
124folic acid-containing compound biosynthetic process (GO:0009396)3.14267587
125apical protein localization (GO:0045176)3.13929643
126L-serine metabolic process (GO:0006563)3.13551403
127positive regulation of megakaryocyte differentiation (GO:0045654)3.13444644
128regulation of mitotic spindle checkpoint (GO:1903504)3.12913889
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12913889
130regulation of meiosis I (GO:0060631)3.12757860
131DNA replication initiation (GO:0006270)3.12152665
132protein localization to endoplasmic reticulum (GO:0070972)3.12031796
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11357840
134rRNA processing (GO:0006364)3.11349446
135positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.11328761
136eye photoreceptor cell differentiation (GO:0001754)3.08728662
137photoreceptor cell differentiation (GO:0046530)3.08728662
138non-recombinational repair (GO:0000726)3.08578203
139double-strand break repair via nonhomologous end joining (GO:0006303)3.08578203
140male meiosis (GO:0007140)3.07808901
141pseudouridine synthesis (GO:0001522)3.07684470
142DNA damage response, detection of DNA damage (GO:0042769)3.05098886
143regulation of ligase activity (GO:0051340)3.04211789
144kinetochore assembly (GO:0051382)3.03869924
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03649026
146positive regulation of cellular amine metabolic process (GO:0033240)3.03646349
147GPI anchor metabolic process (GO:0006505)3.03371193
148spindle checkpoint (GO:0031577)3.02910804
149meiotic cell cycle (GO:0051321)3.01819957
150ceramide biosynthetic process (GO:0046513)2.97774082
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97342081
152regulation of collateral sprouting (GO:0048670)2.97232281
153phosphatidylserine acyl-chain remodeling (GO:0036150)2.95524086
154female gamete generation (GO:0007292)2.93871294
155positive regulation of protein targeting to membrane (GO:0090314)2.93279458
156regulation of meiotic cell cycle (GO:0051445)2.92877721
157dopamine biosynthetic process (GO:0042416)2.91351039
158detection of other organism (GO:0098543)2.89757217
159amyloid precursor protein metabolic process (GO:0042982)2.88135528
160very long-chain fatty acid metabolic process (GO:0000038)2.87129826
161magnesium ion transport (GO:0015693)2.86086463
162asymmetric protein localization (GO:0008105)2.84148198
163keratinocyte proliferation (GO:0043616)2.84112024
164membrane lipid biosynthetic process (GO:0046467)2.83512807
165respiratory electron transport chain (GO:0022904)2.78202408
166regulation of histone H3-K27 methylation (GO:0061085)2.78086834
167epidermal cell differentiation (GO:0009913)2.77613822
168sphingolipid biosynthetic process (GO:0030148)2.77009560
169virion attachment to host cell (GO:0019062)2.76444468
170adhesion of symbiont to host cell (GO:0044650)2.76444468
171microtubule polymerization or depolymerization (GO:0031109)2.75710548
172myelination in peripheral nervous system (GO:0022011)2.74585591
173peripheral nervous system axon ensheathment (GO:0032292)2.74585591
174positive regulation of meiotic cell cycle (GO:0051446)2.74352822
175regulation of neuron projection regeneration (GO:0070570)2.73532658
176regulation of axon regeneration (GO:0048679)2.73532658
177molting cycle (GO:0042303)2.71347103
178hair cycle (GO:0042633)2.71347103
179electron transport chain (GO:0022900)2.70676820
180positive regulation of neurological system process (GO:0031646)2.69416629
181regulation of exit from mitosis (GO:0007096)2.68060003
182positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.65513861
183DNA methylation involved in gamete generation (GO:0043046)2.63750759
184regulation of glomerulus development (GO:0090192)2.62958136
185proteasome assembly (GO:0043248)2.61792447
186negative regulation of protein localization to cell surface (GO:2000009)2.60345874
187organ growth (GO:0035265)2.59489382
188centrosome localization (GO:0051642)2.58342213
189DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.56405578
190negative regulation of acute inflammatory response (GO:0002674)2.54914745
191negative regulation of meiotic cell cycle (GO:0051447)2.52594827

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.81271985
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.31485637
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08381958
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75062991
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.27819431
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24716704
7VDR_22108803_ChIP-Seq_LS180_Human3.20497099
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.19637455
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.18079023
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17735976
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14858426
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06717985
13TAF15_26573619_Chip-Seq_HEK293_Human3.03381686
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90030964
15AR_21909140_ChIP-Seq_LNCAP_Human2.86283710
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.86169978
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83519897
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82901213
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80135298
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68886871
21ELK1_19687146_ChIP-ChIP_HELA_Human2.63353724
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.58092290
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38638904
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31619761
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30043158
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27485037
27GBX2_23144817_ChIP-Seq_PC3_Human2.25780621
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21245928
29DCP1A_22483619_ChIP-Seq_HELA_Human2.18734869
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.17886615
31FOXP3_21729870_ChIP-Seq_TREG_Human2.15669073
32VDR_23849224_ChIP-Seq_CD4+_Human2.13790689
33FUS_26573619_Chip-Seq_HEK293_Human2.12817649
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07511709
35KAP1_22055183_ChIP-Seq_ESCs_Mouse2.07248136
36POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03120362
37XRN2_22483619_ChIP-Seq_HELA_Human2.02660282
38TTF2_22483619_ChIP-Seq_HELA_Human2.00768861
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99898359
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99197045
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98564947
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90811867
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90167640
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88449557
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87035355
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.85974433
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84833718
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80083876
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79187178
50GABP_19822575_ChIP-Seq_HepG2_Human1.77447920
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.77265765
52IGF1R_20145208_ChIP-Seq_DFB_Human1.77165290
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.77017844
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76564121
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73259873
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73214677
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69966867
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.69784048
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68478021
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67886074
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67813789
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67789887
63HTT_18923047_ChIP-ChIP_STHdh_Human1.62739204
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61187909
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59785726
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59622363
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59167424
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58889831
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57095537
70RNF2_27304074_Chip-Seq_NSC_Mouse1.55942338
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.54880775
72ER_23166858_ChIP-Seq_MCF-7_Human1.54652421
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53423150
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.51165121
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48293798
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46645797
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46532462
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.45861124
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45758007
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.44588551
81MYC_18940864_ChIP-ChIP_HL60_Human1.42533827
82AR_21572438_ChIP-Seq_LNCaP_Human1.42398528
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39850689
84IRF1_19129219_ChIP-ChIP_H3396_Human1.38170013
85LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37697722
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36777324
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36737981
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35409187
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35054288
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34879017
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34111421
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.32898814
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32663412
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31606879
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.31318487
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30747108
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.30217657
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29693096
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.28891540
100RUNX1_27457419_Chip-Seq_LIVER_Mouse1.27718206
101KDM5A_27292631_Chip-Seq_BREAST_Human1.27344500
102GATA3_21867929_ChIP-Seq_TH1_Mouse1.27124535
103EST1_17652178_ChIP-ChIP_JURKAT_Human1.26874916
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26725930
105KLF4_18555785_Chip-Seq_ESCs_Mouse1.26182681
106EWS_26573619_Chip-Seq_HEK293_Human1.25912755
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25631380
108SOX2_18555785_Chip-Seq_ESCs_Mouse1.25344085
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24754392
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.24440354
111GATA6_21074721_ChIP-Seq_CACO-2_Human1.24394551
112P300_19829295_ChIP-Seq_ESCs_Human1.23721177
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22424091
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21651522
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.20826493
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.18990000
117AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18582152
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18023562
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18012663
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16655605
121GATA1_26923725_Chip-Seq_HPCs_Mouse1.16020627
122SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15864043
123P53_22387025_ChIP-Seq_ESCs_Mouse1.15580271
124NANOG_16153702_ChIP-ChIP_HESCs_Human1.15149331
125P300_18555785_Chip-Seq_ESCs_Mouse1.13515733
126P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13137893
127* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11870579
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.11291983
129* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10214004
130CBX2_27304074_Chip-Seq_ESCs_Mouse1.09934159
131KDM2B_26808549_Chip-Seq_REH_Human1.08710034
132NMYC_18555785_Chip-Seq_ESCs_Mouse1.08355071
133* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07604915
134PHF8_20622853_ChIP-Seq_HELA_Human1.06532335
135NANOG_20526341_ChIP-Seq_ESCs_Human1.06064089
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05856052
137OCT4_18555785_Chip-Seq_ESCs_Mouse1.05556512
138CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05382559
139ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05137415
140E2F1_18555785_Chip-Seq_ESCs_Mouse1.04362227
141JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03832342
142SMAD3_21741376_ChIP-Seq_EPCs_Human1.03491228
143STAT3_23295773_ChIP-Seq_U87_Human1.03425668
144HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02563599
145SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02428338
146SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02203607
147SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02061974
148* NANOG_19829295_ChIP-Seq_ESCs_Human1.01799045
149* SOX2_19829295_ChIP-Seq_ESCs_Human1.01799045
150TP63_23658742_ChIP-Seq_EP156T_Human1.01436607
151FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00453769
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99675187
153CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98891493
154SMAD_19615063_ChIP-ChIP_OVARY_Human0.98826032
155TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98793799
156SMAD4_21799915_ChIP-Seq_A2780_Human0.98694942
157ELK1_22589737_ChIP-Seq_MCF10A_Human0.98177386
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.98172447
159RBPJ_21746931_ChIP-Seq_IB4_Human0.98081332
160FOXO3_23340844_ChIP-Seq_DLD1_Human0.97482758
161CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96853616
162POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96810029
163SOX17_20123909_ChIP-Seq_XEN_Mouse0.96053258
164BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94574625
165CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92596770
166SOX2_16153702_ChIP-ChIP_HESCs_Human0.91716184
167ELF5_23300383_ChIP-Seq_T47D_Human0.89365330
168POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88539032
169NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84080252
170CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83775783
171KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83593851
172DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82490724
173TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82368115
174STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79695617
175CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76961086
176KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73635739
177ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73273423
178TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71896418
179SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71246819
180TFEB_21752829_ChIP-Seq_HELA_Human0.68793839
181CHD1_26751641_Chip-Seq_LNCaP_Human0.68609064
182SOX2_18692474_ChIP-Seq_MEFs_Mouse0.64561829
183SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.64238269
184TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.63043009
185ZNF263_19887448_ChIP-Seq_K562_Human0.61922161
186FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.59514889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition7.90020868
2MP0002796_impaired_skin_barrier5.91886029
3MP0010094_abnormal_chromosome_stability4.73589367
4MP0003693_abnormal_embryo_hatching4.45388338
5MP0008058_abnormal_DNA_repair4.14209613
6MP0003111_abnormal_nucleus_morphology3.59417867
7MP0010234_abnormal_vibrissa_follicle3.58449756
8MP0005501_abnormal_skin_physiology3.34366628
9MP0003077_abnormal_cell_cycle3.24955071
10MP0003941_abnormal_skin_development3.24233206
11MP0001529_abnormal_vocalization3.15478478
12MP0004381_abnormal_hair_follicle3.11453648
13MP0003718_maternal_effect3.01157520
14MP0003950_abnormal_plasma_membrane2.87144536
15MP0003880_abnormal_central_pattern2.78621185
16MP0010678_abnormal_skin_adnexa2.72040285
17MP0002102_abnormal_ear_morphology2.61386951
18MP0008007_abnormal_cellular_replicative2.61041438
19MP0000920_abnormal_myelination2.49842128
20MP0009697_abnormal_copulation2.41175761
21MP0003329_amyloid_beta_deposits2.32833546
22MP0000383_abnormal_hair_follicle2.28971839
23MP0004185_abnormal_adipocyte_glucose2.27081061
24MP0001905_abnormal_dopamine_level2.23537546
25MP0003186_abnormal_redox_activity2.16548434
26MP0005275_abnormal_skin_tensile2.14303925
27MP0000579_abnormal_nail_morphology2.12647856
28MP0002938_white_spotting2.08122042
29MP0010771_integument_phenotype2.07028744
30MP0001216_abnormal_epidermal_layer2.04270767
31MP0003786_premature_aging2.02486600
32MP0003453_abnormal_keratinocyte_physiol1.91408666
33MP0000372_irregular_coat_pigmentation1.88405536
34MP0003123_paternal_imprinting1.82282488
35MP0006036_abnormal_mitochondrial_physio1.79941037
36MP0004270_analgesia1.75257063
37MP0004947_skin_inflammation1.74246258
38MP0006035_abnormal_mitochondrial_morpho1.72687275
39MP0003136_yellow_coat_color1.64664260
40MP0001730_embryonic_growth_arrest1.64040718
41MP0001293_anophthalmia1.63315633
42MP0008877_abnormal_DNA_methylation1.62580048
43MP0000350_abnormal_cell_proliferation1.61781408
44MP0000566_synostosis1.61066659
45MP0005408_hypopigmentation1.60657190
46MP0002060_abnormal_skin_morphology1.55510525
47MP0000427_abnormal_hair_cycle1.54226361
48MP0006292_abnormal_olfactory_placode1.53587838
49MP0000647_abnormal_sebaceous_gland1.51302246
50MP0009672_abnormal_birth_weight1.47692169
51MP0003646_muscle_fatigue1.47023188
52MP0001697_abnormal_embryo_size1.42884636
53MP0002098_abnormal_vibrissa_morphology1.40771036
54MP0001346_abnormal_lacrimal_gland1.40531711
55MP0004742_abnormal_vestibular_system1.40256932
56MP0010030_abnormal_orbit_morphology1.36903655
57MP0001485_abnormal_pinna_reflex1.32171677
58MP0000462_abnormal_digestive_system1.31403708
59MP0010307_abnormal_tumor_latency1.30484987
60MP0001851_eye_inflammation1.29144868
61MP0000537_abnormal_urethra_morphology1.28623978
62MP0004142_abnormal_muscle_tone1.26584361
63MP0001672_abnormal_embryogenesis/_devel1.25105806
64MP0005380_embryogenesis_phenotype1.25105806
65MP0003567_abnormal_fetal_cardiomyocyte1.23291989
66MP0000358_abnormal_cell_content/1.23184133
67MP0002272_abnormal_nervous_system1.22538797
68MP0005075_abnormal_melanosome_morpholog1.21225671
69MP0009046_muscle_twitch1.20962408
70MP0003632_abnormal_nervous_system1.19758320
71MP0002085_abnormal_embryonic_tissue1.17516239
72MP0001984_abnormal_olfaction1.16879151
73MP0000377_abnormal_hair_follicle1.15599133
74MP0003315_abnormal_perineum_morphology1.14422534
75MP0001188_hyperpigmentation1.14396357
76MP0003191_abnormal_cellular_cholesterol1.13978173
77MP0002080_prenatal_lethality1.13502258
78MP0001486_abnormal_startle_reflex1.12962638
79MP0001881_abnormal_mammary_gland1.12079803
80MP0000467_abnormal_esophagus_morphology1.10356397
81MP0008057_abnormal_DNA_replication1.07865127
82MP0005395_other_phenotype1.05601845
83MP0000313_abnormal_cell_death1.04930094
84MP0002084_abnormal_developmental_patter1.04572022
85MP0000762_abnormal_tongue_morphology1.04122534
86MP0000604_amyloidosis1.03934075
87MP0003984_embryonic_growth_retardation1.00925556
88MP0002088_abnormal_embryonic_growth/wei1.00504899
89MP0003890_abnormal_embryonic-extraembry1.00439224
90MP0010352_gastrointestinal_tract_polyps1.00119256
91MP0009379_abnormal_foot_pigmentation0.99889560
92MP0005410_abnormal_fertilization0.98292164
93MP0002090_abnormal_vision0.95992176
94MP0002064_seizures0.94473526
95MP0002697_abnormal_eye_size0.94254460
96MP0003806_abnormal_nucleotide_metabolis0.92768745
97MP0003937_abnormal_limbs/digits/tail_de0.92691421
98MP0003121_genomic_imprinting0.89628033
99MP0004147_increased_porphyrin_level0.89479739
100MP0002111_abnormal_tail_morphology0.88717164
101MP0009931_abnormal_skin_appearance0.87590899
102MP0001145_abnormal_male_reproductive0.87442268
103MP0003938_abnormal_ear_development0.85471233
104MP0002734_abnormal_mechanical_nocicepti0.85166835
105MP0000778_abnormal_nervous_system0.84760166
106MP0001929_abnormal_gametogenesis0.84291649
107MP0000627_abnormal_mammary_gland0.83718382
108MP0001286_abnormal_eye_development0.83206776
109MP0002751_abnormal_autonomic_nervous0.82625825
110MP0008995_early_reproductive_senescence0.81405057
111MP0005423_abnormal_somatic_nervous0.80622435
112MP0001340_abnormal_eyelid_morphology0.79862946
113MP0002229_neurodegeneration0.79589180
114MP0001727_abnormal_embryo_implantation0.79396620
115MP0001299_abnormal_eye_distance/0.79143752
116MP0001440_abnormal_grooming_behavior0.78311344
117MP0001764_abnormal_homeostasis0.77708019
118MP0002160_abnormal_reproductive_system0.77400976
119MP0004782_abnormal_surfactant_physiolog0.76745098
120MP0002019_abnormal_tumor_incidence0.76679381
121MP0009745_abnormal_behavioral_response0.76364122
122MP0002736_abnormal_nociception_after0.76325211
123MP0004197_abnormal_fetal_growth/weight/0.75569860
124MP0002653_abnormal_ependyma_morphology0.75498012
125MP0003634_abnormal_glial_cell0.75399435
126MP0002282_abnormal_trachea_morphology0.73931056
127MP0000653_abnormal_sex_gland0.72771303
128MP0001191_abnormal_skin_condition0.72160367
129MP0002163_abnormal_gland_morphology0.71527898
130MP0003635_abnormal_synaptic_transmissio0.71219165
131MP0005310_abnormal_salivary_gland0.70687678
132MP0002233_abnormal_nose_morphology0.70667748
133MP0002177_abnormal_outer_ear0.70422750
134MP0003699_abnormal_female_reproductive0.69575206
135MP0009703_decreased_birth_body0.68498263
136MP0002254_reproductive_system_inflammat0.67575400
137MP0005551_abnormal_eye_electrophysiolog0.67285948
138MP0002086_abnormal_extraembryonic_tissu0.66722155
139MP0004145_abnormal_muscle_electrophysio0.66327610
140MP0004924_abnormal_behavior0.66279116
141MP0005386_behavior/neurological_phenoty0.66279116
142MP0002752_abnormal_somatic_nervous0.66189313
143MP0003690_abnormal_glial_cell0.65902225
144MP0006276_abnormal_autonomic_nervous0.65513026
145MP0002572_abnormal_emotion/affect_behav0.64566833
146MP0003936_abnormal_reproductive_system0.64230038
147MP0001119_abnormal_female_reproductive0.64056323
148MP0002095_abnormal_skin_pigmentation0.63914310
149MP0008932_abnormal_embryonic_tissue0.63613334
150MP0001324_abnormal_eye_pigmentation0.63050890
151MP0002009_preneoplasia0.61747315
152MP0004957_abnormal_blastocyst_morpholog0.61146992
153MP0001963_abnormal_hearing_physiology0.61101700
154MP0008260_abnormal_autophagy0.60110988
155MP0000490_abnormal_crypts_of0.60008117
156MP0003878_abnormal_ear_physiology0.59889804
157MP0005377_hearing/vestibular/ear_phenot0.59889804
158MP0002210_abnormal_sex_determination0.59862179
159MP0003698_abnormal_male_reproductive0.59224627
160MP0002067_abnormal_sensory_capabilities0.58569322
161MP0001186_pigmentation_phenotype0.58481050
162MP0004885_abnormal_endolymph0.57345201
163MP0001243_abnormal_dermal_layer0.57148138
164MP0003011_delayed_dark_adaptation0.55194681
165MP0006072_abnormal_retinal_apoptosis0.54545748
166MP0005409_darkened_coat_color0.54426079
167MP0002882_abnormal_neuron_morphology0.53882043

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.55211255
2Parakeratosis (HP:0001036)7.53129591
3Congenital ichthyosiform erythroderma (HP:0007431)7.44627917
4Sensory axonal neuropathy (HP:0003390)4.67037449
5Erythroderma (HP:0001019)4.53432497
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.13549858
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.13549858
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.08233662
9Chromsome breakage (HP:0040012)3.88688993
10Reticulocytopenia (HP:0001896)3.74510949
11Neurofibrillary tangles (HP:0002185)3.69112087
12Gangrene (HP:0100758)3.62904392
13Ectropion (HP:0000656)3.59132020
14Meckel diverticulum (HP:0002245)3.37001860
15Birth length less than 3rd percentile (HP:0003561)3.36666750
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.32299117
17Abnormality of the preputium (HP:0100587)3.23588677
18Abnormality of chromosome stability (HP:0003220)3.18828644
19Acute necrotizing encephalopathy (HP:0006965)3.17457075
20Abnormality of the ileum (HP:0001549)3.13553625
21Colon cancer (HP:0003003)3.11156313
22Macrocytic anemia (HP:0001972)3.10270388
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.09836829
24Lip pit (HP:0100267)3.05037607
25Renal Fanconi syndrome (HP:0001994)3.04835765
26Abnormality of methionine metabolism (HP:0010901)2.97228332
27Hypoplastic pelvis (HP:0008839)2.95338911
28Increased serum pyruvate (HP:0003542)2.94012331
29Abnormality of glycolysis (HP:0004366)2.94012331
30Abnormality of the corticospinal tract (HP:0002492)2.91308316
31Increased hepatocellular lipid droplets (HP:0006565)2.89152333
32Erythema (HP:0010783)2.87943104
33Multiple enchondromatosis (HP:0005701)2.81677690
34Hepatocellular necrosis (HP:0001404)2.79219353
35Mitochondrial inheritance (HP:0001427)2.78527310
36Abnormality of nail color (HP:0100643)2.74502007
37Cerebral hypomyelination (HP:0006808)2.73517372
38Acute encephalopathy (HP:0006846)2.73359367
39Increased serum lactate (HP:0002151)2.69675026
40Adrenal hypoplasia (HP:0000835)2.65876270
41Hypotrichosis (HP:0001006)2.65687925
42Corneal erosion (HP:0200020)2.64449298
43Cerebral inclusion bodies (HP:0100314)2.61356865
44Abnormality of cells of the erythroid lineage (HP:0012130)2.61183633
45Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59530668
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59199499
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59199499
48Type I transferrin isoform profile (HP:0003642)2.58151456
49Abnormal mitochondria in muscle tissue (HP:0008316)2.57773197
50Abnormality of the anterior horn cell (HP:0006802)2.54990025
51Degeneration of anterior horn cells (HP:0002398)2.54990025
52Abnormal lung lobation (HP:0002101)2.54805341
53Lactic acidosis (HP:0003128)2.54401270
54Peripheral hypomyelination (HP:0007182)2.53252011
55Small intestinal stenosis (HP:0012848)2.51979337
56Duodenal stenosis (HP:0100867)2.51979337
57Abnormal number of erythroid precursors (HP:0012131)2.49613339
58Hypohidrosis (HP:0000966)2.48899140
59Abnormality of placental membranes (HP:0011409)2.48209791
60Amniotic constriction ring (HP:0009775)2.48209791
61Leukodystrophy (HP:0002415)2.47284735
62Progressive macrocephaly (HP:0004481)2.42626285
63Abnormality of serum amino acid levels (HP:0003112)2.41912519
64Hyperglycinemia (HP:0002154)2.39983261
65Lipid accumulation in hepatocytes (HP:0006561)2.39648404
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39456793
67Anomalous pulmonary venous return (HP:0010772)2.38970722
68Megaloblastic anemia (HP:0001889)2.35005007
69Exercise intolerance (HP:0003546)2.34779337
70Premature ovarian failure (HP:0008209)2.33668101
71Oral leukoplakia (HP:0002745)2.32795214
72Increased IgE level (HP:0003212)2.29954944
73Pancytopenia (HP:0001876)2.28258288
74Triphalangeal thumb (HP:0001199)2.27785462
75Pruritus (HP:0000989)2.27526413
76Reduced antithrombin III activity (HP:0001976)2.27423290
77Autoamputation (HP:0001218)2.22570743
78Lethargy (HP:0001254)2.20094938
79Sparse eyelashes (HP:0000653)2.19968102
80Abnormality of the duodenum (HP:0002246)2.19956963
81Male infertility (HP:0003251)2.19501565
82Stenosis of the external auditory canal (HP:0000402)2.18435798
83Breast hypoplasia (HP:0003187)2.15984215
84Chronic bronchitis (HP:0004469)2.15614890
85Myelodysplasia (HP:0002863)2.15229428
86Microvesicular hepatic steatosis (HP:0001414)2.14921540
87Rhabdomyosarcoma (HP:0002859)2.14453480
88Absent thumb (HP:0009777)2.13499664
89Ependymoma (HP:0002888)2.13151531
90Respiratory difficulties (HP:0002880)2.11862829
91Increased CSF lactate (HP:0002490)2.11800014
92Septate vagina (HP:0001153)2.11110024
93Cupped ear (HP:0000378)2.09936501
94Absent septum pellucidum (HP:0001331)2.09826344
95Vaginal atresia (HP:0000148)2.05089404
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03675659
97Aplastic anemia (HP:0001915)2.03634947
98Pallor (HP:0000980)2.02252420
99Abnormality of renal resorption (HP:0011038)2.01983463
100Genital tract atresia (HP:0001827)2.01345165
101Abnormality of the carotid arteries (HP:0005344)2.01200153
102Hepatic necrosis (HP:0002605)2.00317106
103Dehydration (HP:0001944)1.98040740
104Intention tremor (HP:0002080)1.96532345
105Lack of skin elasticity (HP:0100679)1.96513261
106Congenital primary aphakia (HP:0007707)1.96111884
107Abnormal protein glycosylation (HP:0012346)1.95891559
108Abnormal glycosylation (HP:0012345)1.95891559
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95891559
110Abnormal protein N-linked glycosylation (HP:0012347)1.95891559
111Abnormality of the salivary glands (HP:0010286)1.95575925
112Brittle hair (HP:0002299)1.95477684
113Sloping forehead (HP:0000340)1.95202096
114Glioma (HP:0009733)1.94473222
115Abnormal gallbladder physiology (HP:0012438)1.93391767
116Cholecystitis (HP:0001082)1.93391767
117Horseshoe kidney (HP:0000085)1.93167408
1183-Methylglutaconic aciduria (HP:0003535)1.92873681
119Nephroblastoma (Wilms tumor) (HP:0002667)1.92284692
120Asthma (HP:0002099)1.91423452
121Optic disc pallor (HP:0000543)1.90346822
122Curly hair (HP:0002212)1.89274854
123Congenital, generalized hypertrichosis (HP:0004540)1.89224356
124Gait imbalance (HP:0002141)1.88644105
125Dysmetria (HP:0001310)1.88566426
126Slow saccadic eye movements (HP:0000514)1.88423707
127Abnormality of glycine metabolism (HP:0010895)1.87944646
128Abnormality of serine family amino acid metabolism (HP:0010894)1.87944646
129Methylmalonic aciduria (HP:0012120)1.86744886
130Hyperglycinuria (HP:0003108)1.86447718
131Neoplasm of the colon (HP:0100273)1.86239106
132Abnormality of the pulmonary veins (HP:0011718)1.85710443
133Dry skin (HP:0000958)1.85480018
134Absent radius (HP:0003974)1.85287264
135Cleft eyelid (HP:0000625)1.85227949
136Retinal dysplasia (HP:0007973)1.85044369
137Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84973990
138Increased muscle lipid content (HP:0009058)1.83906990
139Exertional dyspnea (HP:0002875)1.83874258
140Medial flaring of the eyebrow (HP:0010747)1.83849810
141Spastic paraparesis (HP:0002313)1.82701058
142Postnatal microcephaly (HP:0005484)1.81276719
143Abnormality of alanine metabolism (HP:0010916)1.81123488
144Hyperalaninemia (HP:0003348)1.81123488
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81123488
146Abnormal respiratory motile cilium physiology (HP:0012261)1.80868299
147Testicular atrophy (HP:0000029)1.80663803
148Abnormality of secondary sexual hair (HP:0009888)1.80372725
149Abnormality of the axillary hair (HP:0100134)1.80372725
150Abnormal hair whorl (HP:0010721)1.79813139
151Clubbing of toes (HP:0100760)1.79749884
152Conical tooth (HP:0000698)1.79275340
153Fragile nails (HP:0001808)1.78791081
154Facial cleft (HP:0002006)1.78762143
155Embryonal renal neoplasm (HP:0011794)1.78346084
156Barrel-shaped chest (HP:0001552)1.78004290
157Abnormal auditory evoked potentials (HP:0006958)1.77805651
158Neoplasm of the adrenal gland (HP:0100631)1.77728637
159Palmoplantar keratoderma (HP:0000982)1.76996393
160Methylmalonic acidemia (HP:0002912)1.76680288
161Abnormality of the septum pellucidum (HP:0007375)1.74830331
162CNS hypomyelination (HP:0003429)1.72516999
163Respiratory failure (HP:0002878)1.72216600
164Increased intramyocellular lipid droplets (HP:0012240)1.72034483
165Spastic gait (HP:0002064)1.70559137
166Thickened helices (HP:0000391)1.70154771
167Onion bulb formation (HP:0003383)1.69634216
168Termporal pattern (HP:0011008)1.69192016
169Insidious onset (HP:0003587)1.69192016
170Cerebral edema (HP:0002181)1.68246098
171Severe Myopia (HP:0011003)1.68139895
172Abnormality of the labia minora (HP:0012880)1.66965872
173Nephrogenic diabetes insipidus (HP:0009806)1.66611326
174Atonic seizures (HP:0010819)1.66195578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.26970618
2VRK24.03357867
3OXSR13.47218963
4NEK12.88995481
5TSSK62.86303090
6BMPR22.84325597
7EIF2AK12.81676725
8ERBB42.62123237
9WEE12.60337014
10MAP3K62.59743941
11NME22.53406541
12MAPKAPK52.52248079
13MUSK2.50161591
14PBK2.44007847
15MOS2.42253808
16BRAF2.33216131
17BCR2.31798269
18PLK32.29001479
19KSR22.21474957
20STK162.20649873
21ARAF2.19352916
22TAF12.18472428
23MST42.18270490
24MKNK12.14794479
25MKNK22.12427484
26ZAK2.09381192
27CDK192.04915953
28TRIM281.89503906
29BRSK21.84666271
30NUAK11.71524749
31WNK41.71499831
32TAOK31.70997278
33RAF11.64681497
34MAP3K91.64645746
35FGR1.57110192
36TTK1.54377563
37LATS11.53928678
38CSNK1G31.53518316
39LATS21.53340527
40STK38L1.53039012
41MAP3K121.50227137
42MET1.43386030
43DYRK21.42847415
44PLK41.42702083
45EPHA41.41762977
46CASK1.38676146
47PDK21.33749059
48CSNK1G11.29025469
49PKN11.27798980
50CSNK1A1L1.27414006
51MAP3K131.25523971
52MAPKAPK31.22938135
53BRSK11.20330147
54EIF2AK21.19480391
55ATR1.19130235
56PNCK1.17468760
57TNIK1.17140138
58CSNK1G21.13640759
59RPS6KB21.13453807
60MST1R1.12481217
61PAK61.11421061
62WNK31.10832114
63AURKB1.09906798
64PAK40.98762808
65ALK0.95286760
66CDK70.92865520
67CAMK2A0.90365478
68NEK60.88715149
69CDC70.88638369
70MARK20.87423283
71EPHB10.86894044
72ABL20.86089713
73TAOK10.85228281
74BUB10.84818633
75ROCK20.84297006
76STK100.83912026
77PASK0.83567023
78AURKA0.80347029
79PAK30.78567071
80MAP3K40.78223022
81CHEK10.76404104
82CAMK2B0.76360602
83MELK0.75635960
84TRPM70.75617169
85GRK50.75440724
86DYRK30.74912575
87LIMK10.74611733
88KSR10.73990560
89DAPK10.72066413
90MAP3K20.70982898
91ACVR1B0.70744506
92CHEK20.70538478
93BMPR1B0.68130331
94NTRK20.67778806
95STK240.67570100
96SCYL20.67181564
97ATM0.65469393
98MAP2K40.65465054
99TESK20.65360527
100PRKD20.64584032
101STK40.64324182
102CAMK2D0.64230377
103CSNK2A20.64011389
104CCNB10.63871245
105EPHA20.63838931
106CSNK2A10.63230847
107RPS6KA40.62232470
108TGFBR10.62114634
109INSRR0.60970667
110MAP2K70.59094681
111NME10.58569078
112NEK20.55759594
113TYRO30.55486566
114SMG10.55403817
115IRAK20.53454504
116ERBB30.53084686
117PLK20.53010935
118NTRK10.52653294
119PRKCQ0.52623824
120SGK2230.51223399
121SGK4940.51223399
122EIF2AK30.50981035
123ILK0.50821003
124CSNK1D0.50806114
125FGFR10.50079957
126RIPK40.49129058
127GRK70.48075071
128ADRBK20.47668299
129CAMK2G0.47533313
130MAP3K80.46707828
131VRK10.46433972
132MAPK130.45158081
133UHMK10.43978116
134STK110.43621926
135CDK140.43549172
136CDK30.42419137
137GRK10.41962297
138WNK10.41755119
139CSNK1E0.41273149
140CDK10.40559591
141PRKCI0.38490327
142CDK80.38324682
143BCKDK0.37875164
144CDK150.37724641
145CDK180.35600770
146CDK11A0.35233359
147CDK20.33807911
148STK30.32273939
149ADRBK10.30585318
150PRKCE0.30123262
151SRPK10.29979451
152PLK10.28256733
153PRKDC0.28028050
154CLK10.26444829
155TLK10.26212696
156FLT30.23433456
157PAK10.22966383
158MAP4K20.21927283
159LRRK20.21385025
160CSNK1A10.18798030

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.38737567
2DNA replication_Homo sapiens_hsa030303.99760026
3Fatty acid elongation_Homo sapiens_hsa000623.97109194
4Steroid biosynthesis_Homo sapiens_hsa001003.87647980
5Mismatch repair_Homo sapiens_hsa034303.85489692
6Ether lipid metabolism_Homo sapiens_hsa005653.54523968
7Oxidative phosphorylation_Homo sapiens_hsa001903.41024849
8Linoleic acid metabolism_Homo sapiens_hsa005913.06060968
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93195956
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.80937036
11Sphingolipid metabolism_Homo sapiens_hsa006002.52832860
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.52623042
13Base excision repair_Homo sapiens_hsa034102.29558311
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27677954
15Parkinsons disease_Homo sapiens_hsa050122.24635085
16RNA polymerase_Homo sapiens_hsa030202.23010197
17One carbon pool by folate_Homo sapiens_hsa006702.22414872
18Spliceosome_Homo sapiens_hsa030402.18030019
19Basal transcription factors_Homo sapiens_hsa030222.14362235
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13873579
21Protein export_Homo sapiens_hsa030602.07831038
22Alzheimers disease_Homo sapiens_hsa050102.05574683
23Arachidonic acid metabolism_Homo sapiens_hsa005901.84131813
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80845944
25Huntingtons disease_Homo sapiens_hsa050161.80725842
26Proteasome_Homo sapiens_hsa030501.77294024
27Ovarian steroidogenesis_Homo sapiens_hsa049131.71502461
28Collecting duct acid secretion_Homo sapiens_hsa049661.64013632
29Ribosome_Homo sapiens_hsa030101.59263200
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55080641
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51287096
32Serotonergic synapse_Homo sapiens_hsa047261.50329533
33Histidine metabolism_Homo sapiens_hsa003401.44089509
34Vitamin B6 metabolism_Homo sapiens_hsa007501.37683989
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30364572
36Long-term depression_Homo sapiens_hsa047301.29615904
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29570122
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.28963103
39RNA degradation_Homo sapiens_hsa030181.26748433
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12645420
41Biosynthesis of amino acids_Homo sapiens_hsa012301.09130567
42Carbon metabolism_Homo sapiens_hsa012001.08012726
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95531765
44Glutamatergic synapse_Homo sapiens_hsa047240.92881320
45Non-homologous end-joining_Homo sapiens_hsa034500.91553761
46Folate biosynthesis_Homo sapiens_hsa007900.89796485
47mRNA surveillance pathway_Homo sapiens_hsa030150.89772644
48Butanoate metabolism_Homo sapiens_hsa006500.89659091
49Selenocompound metabolism_Homo sapiens_hsa004500.88312353
50Oocyte meiosis_Homo sapiens_hsa041140.87137331
51Axon guidance_Homo sapiens_hsa043600.86450716
52Rheumatoid arthritis_Homo sapiens_hsa053230.85707669
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85193575
54Homologous recombination_Homo sapiens_hsa034400.84021100
55Nicotine addiction_Homo sapiens_hsa050330.83931806
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.83109481
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80861535
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78894976
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.78348803
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76891969
61p53 signaling pathway_Homo sapiens_hsa041150.75393284
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74811159
63Vibrio cholerae infection_Homo sapiens_hsa051100.71184010
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70713168
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70416807
66Cell cycle_Homo sapiens_hsa041100.70120096
67Cardiac muscle contraction_Homo sapiens_hsa042600.69903922
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69676403
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68899322
70Arginine and proline metabolism_Homo sapiens_hsa003300.68892746
71Ras signaling pathway_Homo sapiens_hsa040140.68359512
72Tight junction_Homo sapiens_hsa045300.65925304
73Metabolic pathways_Homo sapiens_hsa011000.64775826
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.64732893
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64281684
76Renal cell carcinoma_Homo sapiens_hsa052110.62160931
77N-Glycan biosynthesis_Homo sapiens_hsa005100.62131615
78GnRH signaling pathway_Homo sapiens_hsa049120.61169784
79Pentose phosphate pathway_Homo sapiens_hsa000300.59043007
80Retinol metabolism_Homo sapiens_hsa008300.59042414
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58924199
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56513559
83Sulfur relay system_Homo sapiens_hsa041220.53695563
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50916678
85Nucleotide excision repair_Homo sapiens_hsa034200.50025433
86Fatty acid metabolism_Homo sapiens_hsa012120.48768130
87beta-Alanine metabolism_Homo sapiens_hsa004100.48745855
88Pyruvate metabolism_Homo sapiens_hsa006200.46860878
89Circadian rhythm_Homo sapiens_hsa047100.46737297
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45948668
91* Glutathione metabolism_Homo sapiens_hsa004800.45862163
92Sulfur metabolism_Homo sapiens_hsa009200.45847667
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.42981428
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.42900823
95GABAergic synapse_Homo sapiens_hsa047270.42529652
96Long-term potentiation_Homo sapiens_hsa047200.42492334
97ErbB signaling pathway_Homo sapiens_hsa040120.42492132
98Phototransduction_Homo sapiens_hsa047440.42196029
99Tryptophan metabolism_Homo sapiens_hsa003800.41957697
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41916592
101Peroxisome_Homo sapiens_hsa041460.41668639
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41450165
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40610135
104Vitamin digestion and absorption_Homo sapiens_hsa049770.40431155
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39599752
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39244384
107Synaptic vesicle cycle_Homo sapiens_hsa047210.39012105
108Choline metabolism in cancer_Homo sapiens_hsa052310.38537248
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.38466384
110Epstein-Barr virus infection_Homo sapiens_hsa051690.36642872
111Pyrimidine metabolism_Homo sapiens_hsa002400.36629289
112Fatty acid degradation_Homo sapiens_hsa000710.36096263
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35728504
114Tyrosine metabolism_Homo sapiens_hsa003500.34960654
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34588457
116Malaria_Homo sapiens_hsa051440.33693319
117Propanoate metabolism_Homo sapiens_hsa006400.31069743
118TGF-beta signaling pathway_Homo sapiens_hsa043500.30761760
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29751008
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.29193054
121Dorso-ventral axis formation_Homo sapiens_hsa043200.28857981
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27865369
123Morphine addiction_Homo sapiens_hsa050320.27415040
124VEGF signaling pathway_Homo sapiens_hsa043700.26124197
125Thyroid cancer_Homo sapiens_hsa052160.25683548
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25343945
127Taste transduction_Homo sapiens_hsa047420.25154387
128Chemical carcinogenesis_Homo sapiens_hsa052040.24812976
129RNA transport_Homo sapiens_hsa030130.24812141
130Purine metabolism_Homo sapiens_hsa002300.24380062
131Dopaminergic synapse_Homo sapiens_hsa047280.24364158
132Galactose metabolism_Homo sapiens_hsa000520.23965711
133Fanconi anemia pathway_Homo sapiens_hsa034600.23858363
134Fructose and mannose metabolism_Homo sapiens_hsa000510.23745019
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23405844
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.23038970
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20431221
138MAPK signaling pathway_Homo sapiens_hsa040100.19947436
139Caffeine metabolism_Homo sapiens_hsa002320.19565762
140Phenylalanine metabolism_Homo sapiens_hsa003600.18211927
141Basal cell carcinoma_Homo sapiens_hsa052170.11011806
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07863863
143Arginine biosynthesis_Homo sapiens_hsa002200.07618354
144Hippo signaling pathway_Homo sapiens_hsa043900.07107587
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05241380

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