GGCX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)8.84827118
2cellular response to ATP (GO:0071318)8.79981619
3negative regulation of cell aging (GO:0090344)8.51793794
4DNA strand renaturation (GO:0000733)8.31966910
5GDP-mannose metabolic process (GO:0019673)7.30153641
6mitotic cell cycle arrest (GO:0071850)7.15345275
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.84976074
8L-phenylalanine catabolic process (GO:0006559)6.84976074
9regulation of synapse structural plasticity (GO:0051823)6.83949021
10transepithelial transport (GO:0070633)6.52202334
11meiotic chromosome segregation (GO:0045132)6.51012786
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.45605819
13L-phenylalanine metabolic process (GO:0006558)6.45605819
14aromatic amino acid family catabolic process (GO:0009074)6.14555353
15lens fiber cell differentiation (GO:0070306)5.99200079
16detection of light stimulus involved in visual perception (GO:0050908)5.94240647
17detection of light stimulus involved in sensory perception (GO:0050962)5.94240647
18regulation of cytokine production involved in inflammatory response (GO:1900015)5.77781301
19adenosine receptor signaling pathway (GO:0001973)5.76198695
20tryptophan catabolic process (GO:0006569)5.54119729
21indole-containing compound catabolic process (GO:0042436)5.54119729
22indolalkylamine catabolic process (GO:0046218)5.54119729
23tryptophan metabolic process (GO:0006568)5.36155109
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.30642824
25bile acid biosynthetic process (GO:0006699)5.28463451
26kynurenine metabolic process (GO:0070189)5.19007636
27* peptidyl-glutamic acid carboxylation (GO:0017187)5.17441730
28* protein carboxylation (GO:0018214)5.17441730
29regulation of protein activation cascade (GO:2000257)5.15425808
30negative regulation of fibrinolysis (GO:0051918)5.13439771
31glyoxylate metabolic process (GO:0046487)5.12078533
32complement activation, alternative pathway (GO:0006957)5.10917783
33estrogen biosynthetic process (GO:0006703)5.09989112
34regulation of fibrinolysis (GO:0051917)5.09750354
35G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.04653123
36purinergic nucleotide receptor signaling pathway (GO:0035590)5.00356454
37alpha-linolenic acid metabolic process (GO:0036109)4.93733491
38rRNA methylation (GO:0031167)4.92671415
39urea metabolic process (GO:0019627)4.86726332
40urea cycle (GO:0000050)4.86726332
41regulation of complement activation (GO:0030449)4.85123280
42high-density lipoprotein particle remodeling (GO:0034375)4.82259228
43tyrosine metabolic process (GO:0006570)4.75823867
44behavioral response to nicotine (GO:0035095)4.69848331
45sulfur amino acid catabolic process (GO:0000098)4.68966151
46bile acid metabolic process (GO:0008206)4.58141234
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.54878576
48aromatic amino acid family metabolic process (GO:0009072)4.53565809
49positive regulation of heat generation (GO:0031652)4.47512445
50nitrogen cycle metabolic process (GO:0071941)4.43572018
51negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.43401021
52homocysteine metabolic process (GO:0050667)4.40245994
53acylglycerol homeostasis (GO:0055090)4.39940551
54triglyceride homeostasis (GO:0070328)4.39940551
55response to ATP (GO:0033198)4.33856073
56nucleotide-sugar biosynthetic process (GO:0009226)4.31616549
57cysteine metabolic process (GO:0006534)4.31413227
58reverse cholesterol transport (GO:0043691)4.30524092
59rRNA modification (GO:0000154)4.29824442
60purine ribonucleotide transport (GO:0015868)4.29779003
61heme transport (GO:0015886)4.26143076
62positive regulation of protein kinase C signaling (GO:0090037)4.23172594
63regulation of cholesterol esterification (GO:0010872)4.19751518
64protein-lipid complex remodeling (GO:0034368)4.16454814
65macromolecular complex remodeling (GO:0034367)4.16454814
66plasma lipoprotein particle remodeling (GO:0034369)4.16454814
67regulation of triglyceride catabolic process (GO:0010896)4.16285678
68nucleotide transmembrane transport (GO:1901679)4.13823734
69serine family amino acid catabolic process (GO:0009071)4.12486844
70indolalkylamine metabolic process (GO:0006586)4.10989593
71peristalsis (GO:0030432)4.10291059
72regulation of cell aging (GO:0090342)4.10204992
73regulation of phospholipid biosynthetic process (GO:0071071)4.09512760
74bile acid and bile salt transport (GO:0015721)4.08149969
75amino-acid betaine metabolic process (GO:0006577)4.05996685
76coenzyme catabolic process (GO:0009109)4.03462713
77alpha-amino acid catabolic process (GO:1901606)4.03293911
78phospholipid efflux (GO:0033700)3.98026959
79plasma lipoprotein particle clearance (GO:0034381)3.96772647
80imidazole-containing compound metabolic process (GO:0052803)3.95662850
81sphingomyelin metabolic process (GO:0006684)3.89769489
82nucleoside transmembrane transport (GO:1901642)3.88402241
83cellular glucuronidation (GO:0052695)3.88328159
84cellular biogenic amine catabolic process (GO:0042402)3.86794844
85amine catabolic process (GO:0009310)3.86794844
86cholesterol efflux (GO:0033344)3.85700476
87cellular ketone body metabolic process (GO:0046950)3.84327375
88fibrinolysis (GO:0042730)3.83397369
89lysine metabolic process (GO:0006553)3.83380607
90lysine catabolic process (GO:0006554)3.83380607
91phosphate ion homeostasis (GO:0055062)3.81473581
92trivalent inorganic anion homeostasis (GO:0072506)3.81473581
93type B pancreatic cell proliferation (GO:0044342)3.81232258
94phosphate ion transmembrane transport (GO:0035435)3.78000154
95cellular amino acid catabolic process (GO:0009063)3.72725853
96granulocyte differentiation (GO:0030851)3.71494935
97adenine nucleotide transport (GO:0051503)3.68269725
98iron coordination entity transport (GO:1901678)3.64261874
99cellular anion homeostasis (GO:0030002)3.63127103
100benzene-containing compound metabolic process (GO:0042537)3.62791876
101sphingosine metabolic process (GO:0006670)3.61907027
102negative regulation of protein activation cascade (GO:2000258)3.61338815
103semaphorin-plexin signaling pathway (GO:0071526)3.60825963
104sensory perception of taste (GO:0050909)3.59757482
105phosphatidylglycerol biosynthetic process (GO:0006655)3.59669060
106negative regulation of lipase activity (GO:0060192)3.59335950
1073-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.59165990
108purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.59165990
109negative regulation of sterol transport (GO:0032372)3.57639420
110negative regulation of cholesterol transport (GO:0032375)3.57639420
111plasma lipoprotein particle assembly (GO:0034377)3.55698697
112cellular modified amino acid catabolic process (GO:0042219)3.53692214
113phospholipid homeostasis (GO:0055091)3.52750239
114low-density lipoprotein particle remodeling (GO:0034374)3.51261061
115glutamate metabolic process (GO:0006536)3.49593672
116complement activation (GO:0006956)3.47726601
117protein activation cascade (GO:0072376)3.47580110
118regulation of heat generation (GO:0031650)3.47333712
119positive regulation of lipoprotein lipase activity (GO:0051006)3.47319682
120positive regulation of triglyceride lipase activity (GO:0061365)3.47319682
121very-low-density lipoprotein particle assembly (GO:0034379)3.46989252
122complement activation, classical pathway (GO:0006958)3.46778034
123blood coagulation, intrinsic pathway (GO:0007597)3.46215992
124opsonization (GO:0008228)3.45937435
125ketone body metabolic process (GO:1902224)3.44449306
126positive regulation of fatty acid beta-oxidation (GO:0032000)3.44010496
127diol metabolic process (GO:0034311)3.43878039
128cholesterol homeostasis (GO:0042632)3.43098414
129urinary tract smooth muscle contraction (GO:0014848)3.42894529
130glucuronate metabolic process (GO:0019585)3.42527489
131uronic acid metabolic process (GO:0006063)3.42527489
132lipoprotein metabolic process (GO:0042157)3.41538292
133dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.39014826
134regulation of cholesterol homeostasis (GO:2000188)3.38395795
135organic acid catabolic process (GO:0016054)3.37848888
136carboxylic acid catabolic process (GO:0046395)3.37848888
137purinergic receptor signaling pathway (GO:0035587)3.37315212
138sterol homeostasis (GO:0055092)3.37246846
139regulation of plasminogen activation (GO:0010755)3.36655812
140drug catabolic process (GO:0042737)3.34030184
141arginine metabolic process (GO:0006525)3.31521011
142regulation of bile acid biosynthetic process (GO:0070857)3.30844172
143folic acid metabolic process (GO:0046655)3.30088439
144intestinal cholesterol absorption (GO:0030299)3.29891778
145positive regulation of lipid catabolic process (GO:0050996)3.29623069
146glycine metabolic process (GO:0006544)3.28979848
147purine nucleotide transport (GO:0015865)3.28908862
148fatty acid oxidation (GO:0019395)3.28833698
149fatty acid beta-oxidation (GO:0006635)3.28336952
150monocarboxylic acid catabolic process (GO:0072329)3.27710055
151cytolysis (GO:0019835)3.27159597
152DNA replication checkpoint (GO:0000076)3.25438414
153cofactor catabolic process (GO:0051187)3.24848258
154plasma lipoprotein particle organization (GO:0071827)3.24455166
155short-chain fatty acid metabolic process (GO:0046459)3.23930727
156UV protection (GO:0009650)3.22497858
157phosphatidylethanolamine biosynthetic process (GO:0006646)3.20153935
158proline metabolic process (GO:0006560)3.17974747
159melanin biosynthetic process (GO:0042438)3.17223302
160alkaloid metabolic process (GO:0009820)3.17148171
161negative regulation of interleukin-8 production (GO:0032717)3.17094124
162phosphate ion transport (GO:0006817)3.08718811
163proline biosynthetic process (GO:0006561)3.08180392
164cilium or flagellum-dependent cell motility (GO:0001539)3.07811970
165cardiolipin metabolic process (GO:0032048)3.07780217
166sphingoid metabolic process (GO:0046519)3.06474451
167estrogen metabolic process (GO:0008210)3.04349070
168mannose metabolic process (GO:0006013)3.03778545
169respiratory chain complex IV assembly (GO:0008535)2.97318229
170exogenous drug catabolic process (GO:0042738)2.93491814
171sex determination (GO:0007530)2.93107089
172phosphatidylethanolamine metabolic process (GO:0046337)2.92434375
173regulation of nuclear cell cycle DNA replication (GO:0033262)2.90294017
174grooming behavior (GO:0007625)2.90154944
175secondary metabolite biosynthetic process (GO:0044550)2.88110401
176oligosaccharide catabolic process (GO:0009313)2.84071326
177glutathione derivative biosynthetic process (GO:1901687)2.80676670
178glutathione derivative metabolic process (GO:1901685)2.80676670
179androgen biosynthetic process (GO:0006702)2.78889615
180endocytic recycling (GO:0032456)2.75393398
181nucleoside transport (GO:0015858)2.75159866
182ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.74080902
183nucleoside bisphosphate biosynthetic process (GO:0033866)2.74080902
184purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.74080902
185response to gravity (GO:0009629)2.73077611
186melanin metabolic process (GO:0006582)2.70162020
187negative regulation of digestive system process (GO:0060457)2.70050271
188folic acid transport (GO:0015884)2.69242804
189neuromuscular synaptic transmission (GO:0007274)2.66014863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.21305015
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.05990863
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.99335633
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.83551442
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.59071454
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.37997808
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.98656265
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.96282733
9VDR_21846776_ChIP-Seq_THP-1_Human3.82908597
10STAT6_21828071_ChIP-Seq_BEAS2B_Human3.72335050
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.23715128
12P68_20966046_ChIP-Seq_HELA_Human3.13320915
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.02013268
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.99396205
15* XRN2_22483619_ChIP-Seq_HELA_Human2.96309294
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75371683
17LXR_22292898_ChIP-Seq_THP-1_Human2.64035324
18* E2F1_20622854_ChIP-Seq_HELA_Human2.60995898
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.45142074
20GATA1_22025678_ChIP-Seq_K562_Human2.42991770
21ERG_21242973_ChIP-ChIP_JURKAT_Human2.33919190
22BCOR_27268052_Chip-Seq_Bcells_Human2.33408264
23CTCF_27219007_Chip-Seq_Bcells_Human2.33394716
24MAF_26560356_Chip-Seq_TH2_Human2.32981422
25BCL6_27268052_Chip-Seq_Bcells_Human2.29994019
26PHF8_20622854_ChIP-Seq_HELA_Human2.29063377
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.28744602
28MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.27291540
29CLOCK_20551151_ChIP-Seq_293T_Human2.09712103
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05855396
31RACK7_27058665_Chip-Seq_MCF-7_Human2.02521342
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0641118
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.99748045
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95053312
35* FOXP1_21924763_ChIP-Seq_HESCs_Human1.94745999
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.94541723
37SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.93834676
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93500189
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.93240057
40CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.92908457
41TP53_22127205_ChIP-Seq_IMR90_Human1.85535871
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.84112483
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.82702730
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82511080
45CTCF_21964334_Chip-Seq_Bcells_Human1.81558352
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81445317
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80722585
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77509794
49SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.76421233
50* CTCF_20526341_ChIP-Seq_ESCs_Human1.75567505
51ERA_21632823_ChIP-Seq_H3396_Human1.71199399
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.70757426
53* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.67370998
54* FOXA2_19822575_ChIP-Seq_HepG2_Human1.66625732
55SMC4_20622854_ChIP-Seq_HELA_Human1.66031355
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.63276583
57VDR_24763502_ChIP-Seq_THP-1_Human1.61040761
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60376506
59* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60304654
60MAF_26560356_Chip-Seq_TH1_Human1.56920852
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.55740479
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.54484701
63* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.52100551
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51347973
65CTCF_21964334_ChIP-Seq_BJAB-B_Human1.48676805
66FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44172667
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42690022
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41215544
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.39321049
70CREB1_26743006_Chip-Seq_LNCaP_Human1.37631528
71* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36009848
72SA1_27219007_Chip-Seq_Bcells_Human1.34066554
73* NANOG_20526341_ChIP-Seq_ESCs_Human1.31388066
74* P53_21459846_ChIP-Seq_SAOS-2_Human1.30936208
75HTT_18923047_ChIP-ChIP_STHdh_Human1.30620302
76* HNF4A_19822575_ChIP-Seq_HepG2_Human1.27977879
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27138602
78NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.25987896
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25417784
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25417784
81GABP_19822575_ChIP-Seq_HepG2_Human1.23216228
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23073092
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21739001
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21726575
85MYC_19829295_ChIP-Seq_ESCs_Human1.20754476
86ETS1_21867929_ChIP-Seq_TH2_Mouse1.19739567
87ATF3_27146783_Chip-Seq_COLON_Human1.19396555
88P300_27268052_Chip-Seq_Bcells_Human1.19309697
89FOXM1_23109430_ChIP-Seq_U2OS_Human1.19083099
90DCP1A_22483619_ChIP-Seq_HELA_Human1.18985568
91OCT4_20526341_ChIP-Seq_ESCs_Human1.18830724
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17524296
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17083787
94UBF1/2_26484160_Chip-Seq_HMECs_Human1.15072168
95* TAF2_19829295_ChIP-Seq_ESCs_Human1.14865992
96JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.14384415
97* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.13891252
98* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13252146
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.11946605
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09688138
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08861589
102SOX2_21211035_ChIP-Seq_LN229_Human1.07428852
103CIITA_25753668_ChIP-Seq_RAJI_Human1.07404491
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06790555
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06745187
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05940149
107UTX_26944678_Chip-Seq_JUKART_Human1.05048001
108TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04611133
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04120882
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03881648
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03752219
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03001218
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01949513
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00743769
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00436535
116PIAS1_25552417_ChIP-Seq_VCAP_Human0.98628881
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98215316
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97974447
119CTCF_26484167_Chip-Seq_Bcells_Mouse0.97566106
120RAC3_21632823_ChIP-Seq_H3396_Human0.97228661
121GABP_17652178_ChIP-ChIP_JURKAT_Human0.97133440
122GATA3_21867929_ChIP-Seq_CD8_Mouse0.96889250
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96857640
124IRF8_22096565_ChIP-ChIP_GC-B_Human0.95999385
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95581124
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95140731
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93586263
128GATA4_25053715_ChIP-Seq_YYC3_Human0.89825939
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.89713774
130RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89274788
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88947357
132Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88226591
133* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87243447
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.86956682
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86948614
136SOX2_20726797_ChIP-Seq_SW620_Human0.84641329
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82766687
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.81727837
139CJUN_26792858_Chip-Seq_BT549_Human0.81506938
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81023518
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80716744
142EP300_21415370_ChIP-Seq_HL-1_Mouse0.79554834
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76412912
144BCAT_22108803_ChIP-Seq_LS180_Human0.75708165
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75569602
146PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.74541188
147FOXA1_25552417_ChIP-Seq_VCAP_Human0.74381169
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71895166
149AR_20517297_ChIP-Seq_VCAP_Human0.68907128
150AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68828840
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.66876441
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.63314999
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.63311827
154RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62100453
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.61284887
156CDX2_19796622_ChIP-Seq_MESCs_Mouse0.59078876
157TP53_18474530_ChIP-ChIP_U2OS_Human0.58996969
158* TBX20_22328084_ChIP-Seq_HEART_Mouse0.57899825
159* TBX20_22080862_ChIP-Seq_HEART_Mouse0.57899825
160FOXO3_23340844_ChIP-Seq_DLD1_Human0.57511652
161SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.57415857
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.57107587
163TP63_23658742_ChIP-Seq_EP156T_Human0.56747863
164RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56588949
165CDX2_22108803_ChIP-Seq_LS180_Human0.55870892
166CBP_21632823_ChIP-Seq_H3396_Human0.55689147
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.54631732
168EZH2_27294783_Chip-Seq_NPCs_Mouse0.54560912
169WT1_19549856_ChIP-ChIP_CCG9911_Human0.54244912
170GBX2_23144817_ChIP-Seq_PC3_Human0.54066791
171STAT1_17558387_ChIP-Seq_HELA_Human0.53909032
172GATA1_19941826_ChIP-Seq_K562_Human0.53194035
173PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.53157408
174GATA3_24758297_ChIP-Seq_MCF-7_Human0.52181434
175FOXM1_26456572_ChIP-Seq_MCF-7_Human0.50336381
176PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.50127092
177SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.49745154
178SOX9_24532713_ChIP-Seq_HFSC_Mouse0.48884565
179FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48551938
180* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.48303987
181PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.47335215
182TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.47147143
183* RARB_24833708_ChIP-Seq_LIVER_Mouse0.46960648
184ESR1_15608294_ChIP-ChIP_MCF-7_Human0.46867337
185CRX_20693478_ChIP-Seq_RETINA_Mouse0.46408892
186RARA_24833708_ChIP-Seq_LIVER_Mouse0.46397049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.54973754
2MP0002139_abnormal_hepatobiliary_system7.42644683
3MP0005360_urolithiasis6.27328060
4MP0005085_abnormal_gallbladder_physiolo5.83217278
5MP0005365_abnormal_bile_salt5.78294900
6MP0001986_abnormal_taste_sensitivity5.64002826
7MP0005174_abnormal_tail_pigmentation5.45114462
8MP0005423_abnormal_somatic_nervous4.99907931
9MP0003136_yellow_coat_color4.79093231
10MP0008875_abnormal_xenobiotic_pharmacok4.19713706
11MP0003252_abnormal_bile_duct3.86432234
12MP0003806_abnormal_nucleotide_metabolis3.41227479
13MP0003195_calcinosis3.33617137
14MP0010329_abnormal_lipoprotein_level3.29430307
15MP0005083_abnormal_biliary_tract2.88408680
16MP0005409_darkened_coat_color2.61259178
17MP0000751_myopathy2.57660179
18MP0009840_abnormal_foam_cell2.54482848
19MP0001188_hyperpigmentation2.46473240
20MP0001666_abnormal_nutrient_absorption2.45880388
21MP0005332_abnormal_amino_acid2.40480598
22MP0002160_abnormal_reproductive_system2.24492430
23MP0002638_abnormal_pupillary_reflex2.22557396
24MP0001968_abnormal_touch/_nociception2.20944768
25MP0003191_abnormal_cellular_cholesterol2.07861239
26MP0002118_abnormal_lipid_homeostasis2.04695490
27MP0008438_abnormal_cutaneous_collagen2.04039884
28MP0002138_abnormal_hepatobiliary_system1.97864730
29MP0005330_cardiomyopathy1.95542692
30MP0000609_abnormal_liver_physiology1.91202431
31MP0004019_abnormal_vitamin_homeostasis1.88125593
32MP0001502_abnormal_circadian_rhythm1.87845709
33MP0003868_abnormal_feces_composition1.86493082
34MP0000750_abnormal_muscle_regeneration1.84170494
35MP0009697_abnormal_copulation1.73928689
36MP0002736_abnormal_nociception_after1.73535630
37MP0000538_abnormal_urinary_bladder1.73111041
38MP0010368_abnormal_lymphatic_system1.69740411
39MP0001764_abnormal_homeostasis1.68994067
40MP0005319_abnormal_enzyme/_coenzyme1.62139800
41MP0005551_abnormal_eye_electrophysiolog1.54931506
42MP0005410_abnormal_fertilization1.51111638
43MP0005670_abnormal_white_adipose1.46887541
44MP0003453_abnormal_keratinocyte_physiol1.44495309
45MP0000015_abnormal_ear_pigmentation1.44055863
46MP0005408_hypopigmentation1.42358745
47MP0005220_abnormal_exocrine_pancreas1.36967570
48MP0009384_cardiac_valve_regurgitation1.35970631
49MP0003705_abnormal_hypodermis_morpholog1.33722996
50MP0001919_abnormal_reproductive_system1.29437059
51MP0009643_abnormal_urine_homeostasis1.28300567
52MP0005503_abnormal_tendon_morphology1.27951568
53MP0005275_abnormal_skin_tensile1.20737844
54MP0005584_abnormal_enzyme/coenzyme_acti1.18595032
55MP0004782_abnormal_surfactant_physiolog1.16147892
56MP0005647_abnormal_sex_gland1.10549363
57MP0003724_increased_susceptibility_to1.10285988
58MP0001324_abnormal_eye_pigmentation1.09900512
59MP0005501_abnormal_skin_physiology1.08175078
60MP0003111_abnormal_nucleus_morphology1.07765608
61MP0002078_abnormal_glucose_homeostasis1.06513818
62MP0003878_abnormal_ear_physiology1.05009918
63MP0005377_hearing/vestibular/ear_phenot1.05009918
64MP0002837_dystrophic_cardiac_calcinosis1.04942025
65MP0004381_abnormal_hair_follicle1.03075816
66MP0000013_abnormal_adipose_tissue1.02750163
67MP0000598_abnormal_liver_morphology1.02748679
68MP0002735_abnormal_chemical_nociception1.01523850
69MP0005389_reproductive_system_phenotype0.99972224
70MP0005084_abnormal_gallbladder_morpholo0.98246280
71MP0002909_abnormal_adrenal_gland0.94682648
72MP0000747_muscle_weakness0.91509561
73MP0003279_aneurysm0.91210336
74MP0003186_abnormal_redox_activity0.91195952
75MP0002876_abnormal_thyroid_physiology0.90677095
76MP0001765_abnormal_ion_homeostasis0.89723511
77MP0005253_abnormal_eye_physiology0.88318241
78MP0009764_decreased_sensitivity_to0.86725016
79MP0005451_abnormal_body_composition0.86048163
80MP0002254_reproductive_system_inflammat0.85982705
81MP0009642_abnormal_blood_homeostasis0.85593498
82MP0009763_increased_sensitivity_to0.84935795
83MP0005636_abnormal_mineral_homeostasis0.84217817
84MP0002295_abnormal_pulmonary_circulatio0.83346338
85MP0000470_abnormal_stomach_morphology0.82803924
86MP0002060_abnormal_skin_morphology0.81393414
87MP0001944_abnormal_pancreas_morphology0.81362123
88MP0001661_extended_life_span0.81092229
89MP0002928_abnormal_bile_duct0.80031342
90MP0005334_abnormal_fat_pad0.79540063
91MP0005058_abnormal_lysosome_morphology0.78284284
92MP0004215_abnormal_myocardial_fiber0.77529803
93MP0002971_abnormal_brown_adipose0.76941219
94MP0000367_abnormal_coat/_hair0.76085306
95MP0004272_abnormal_basement_membrane0.75671321
96MP0009780_abnormal_chondrocyte_physiolo0.74464444
97MP0003137_abnormal_impulse_conducting0.73880974
98MP0005376_homeostasis/metabolism_phenot0.73163472
99MP0003011_delayed_dark_adaptation0.73010288
100MP0005257_abnormal_intraocular_pressure0.71981767
101MP0008469_abnormal_protein_level0.71613968
102MP0000639_abnormal_adrenal_gland0.71134001
103MP0001756_abnormal_urination0.70348518
104MP0001664_abnormal_digestion0.69573147
105MP0002168_other_aberrant_phenotype0.69030188
106MP0005535_abnormal_body_temperature0.67822050
107MP0003656_abnormal_erythrocyte_physiolo0.67160116
108MP0003690_abnormal_glial_cell0.65912085
109MP0006054_spinal_hemorrhage0.64663575
110MP0000230_abnormal_systemic_arterial0.64350943
111MP0001243_abnormal_dermal_layer0.63923278
112MP0009765_abnormal_xenobiotic_induced0.63241008
113MP0003718_maternal_effect0.62987849
114MP0002693_abnormal_pancreas_physiology0.62516416
115MP0004043_abnormal_pH_regulation0.62490911
116MP0002877_abnormal_melanocyte_morpholog0.61740542
117MP0004130_abnormal_muscle_cell0.60284426
118MP0010771_integument_phenotype0.59744085
119MP0002896_abnormal_bone_mineralization0.59437755
120MP0003077_abnormal_cell_cycle0.58524867
121MP0003953_abnormal_hormone_level0.58174788
122MP0005448_abnormal_energy_balance0.56446320
123MP0002136_abnormal_kidney_physiology0.56247578
124MP0000358_abnormal_cell_content/0.55555439
125MP0003315_abnormal_perineum_morphology0.55213238
126MP0005666_abnormal_adipose_tissue0.55021087
127MP0001542_abnormal_bone_strength0.53417806
128MP0001905_abnormal_dopamine_level0.52687020
129MP0004883_abnormal_blood_vessel0.52536704
130MP0000003_abnormal_adipose_tissue0.52475920
131MP0005164_abnormal_response_to0.51898116
132MP0005595_abnormal_vascular_smooth0.51748760
133MP0003959_abnormal_lean_body0.51119464
134MP0005395_other_phenotype0.50723551
135MP0001958_emphysema0.49635859
136MP0005023_abnormal_wound_healing0.49601688
137MP0002933_joint_inflammation0.49240432
138MP0002108_abnormal_muscle_morphology0.47458247
139MP0004197_abnormal_fetal_growth/weight/0.47254856
140MP0000249_abnormal_blood_vessel0.46755546
141MP0002075_abnormal_coat/hair_pigmentati0.45896532
142MP0000566_synostosis0.45574550
143MP0005375_adipose_tissue_phenotype0.45388581
144MP0009931_abnormal_skin_appearance0.45338052
145MP0010386_abnormal_urinary_bladder0.45299394
146MP0001879_abnormal_lymphatic_vessel0.44759915
147MP0003632_abnormal_nervous_system0.43942437
148MP0004264_abnormal_extraembryonic_tissu0.43656806
149MP0006138_congestive_heart_failure0.43633840
150MP0004957_abnormal_blastocyst_morpholog0.43324035
151MP0008770_decreased_survivor_rate0.41955822
152MP0000604_amyloidosis0.41942125
153MP0005195_abnormal_posterior_eye0.41629967
154MP0001191_abnormal_skin_condition0.41254601
155MP0008872_abnormal_physiological_respon0.40638687
156MP0001348_abnormal_lacrimal_gland0.38922448
157MP0003448_altered_tumor_morphology0.38827683
158MP0005076_abnormal_cell_differentiation0.37768228
159MP0005391_vision/eye_phenotype0.36835469
160MP0001346_abnormal_lacrimal_gland0.36471376
161MP0002210_abnormal_sex_determination0.35505413

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.72952274
2Testicular atrophy (HP:0000029)6.67206380
3Deep venous thrombosis (HP:0002625)6.63560412
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.57691594
5Rib fusion (HP:0000902)6.38039314
6* Prolonged partial thromboplastin time (HP:0003645)6.21459162
7Xanthomatosis (HP:0000991)5.83587348
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.71293777
9Dyschromatopsia (HP:0007641)5.55280822
10Mesangial abnormality (HP:0001966)5.54438146
11Attenuation of retinal blood vessels (HP:0007843)5.48306548
12Hyperlipoproteinemia (HP:0010980)5.32310889
13Complement deficiency (HP:0004431)5.17170065
14Hypobetalipoproteinemia (HP:0003563)5.14615920
15Rectovaginal fistula (HP:0000143)5.04145910
16Rectal fistula (HP:0100590)5.04145910
17Hypoglycemic coma (HP:0001325)4.87701539
18Vaginal fistula (HP:0004320)4.72637547
19Increased hepatocellular lipid droplets (HP:0006565)4.65236681
20Popliteal pterygium (HP:0009756)4.63705900
21Poikiloderma (HP:0001029)4.55431473
22Intestinal fistula (HP:0100819)4.54468324
23Lipid accumulation in hepatocytes (HP:0006561)4.46611968
24* Abnormality of the common coagulation pathway (HP:0010990)4.46211428
25Facial diplegia (HP:0001349)4.43548611
26Renal Fanconi syndrome (HP:0001994)4.42382804
27* Joint hemorrhage (HP:0005261)4.35125625
28Ulnar bowing (HP:0003031)4.30394065
29Akinesia (HP:0002304)4.29660629
30Ketosis (HP:0001946)4.24568501
31Thin bony cortex (HP:0002753)4.24214914
32Facial hemangioma (HP:0000329)4.16665928
33Aplasia of the musculature (HP:0100854)4.15002168
34* Abnormality of the intrinsic pathway (HP:0010989)4.14109966
35Hypolipoproteinemia (HP:0010981)4.11505848
36Conjugated hyperbilirubinemia (HP:0002908)4.06626598
37Hypoglycemic seizures (HP:0002173)4.06266622
38Coronal craniosynostosis (HP:0004440)4.04013026
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.03053246
40Epidermoid cyst (HP:0200040)4.02041179
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.01006011
42Congenital stationary night blindness (HP:0007642)4.00703785
43Fat malabsorption (HP:0002630)3.92443445
44Choroideremia (HP:0001139)3.90441384
45Hypoalphalipoproteinemia (HP:0003233)3.83994106
46Annular pancreas (HP:0001734)3.82905072
47Abnormality of complement system (HP:0005339)3.73785515
48Hyperinsulinemic hypoglycemia (HP:0000825)3.72253049
49Ketoacidosis (HP:0001993)3.71985796
50Decreased electroretinogram (ERG) amplitude (HP:0000654)3.71137087
51Decreased central vision (HP:0007663)3.70625757
52Turricephaly (HP:0000262)3.68582390
53Hyperammonemia (HP:0001987)3.68021664
54Abnormality of methionine metabolism (HP:0010901)3.60758922
55Abnormality of glutamine family amino acid metabolism (HP:0010902)3.60090231
56Abnormality of sulfur amino acid metabolism (HP:0004339)3.58468053
57Hyperglycinemia (HP:0002154)3.57196261
58Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.55446113
59Fetal akinesia sequence (HP:0001989)3.48371072
60Abnormal albumin level (HP:0012116)3.45908122
61Hypoalbuminemia (HP:0003073)3.45908122
62Bony spicule pigmentary retinopathy (HP:0007737)3.43177799
63Chorioretinal atrophy (HP:0000533)3.43000220
64Abnormality of aspartate family amino acid metabolism (HP:0010899)3.42856930
65Hyperglycinuria (HP:0003108)3.40509988
66Amniotic constriction ring (HP:0009775)3.30274886
67Abnormality of placental membranes (HP:0011409)3.30274886
68Atrioventricular block (HP:0001678)3.29096451
69Abnormality of glycine metabolism (HP:0010895)3.23504176
70Abnormality of serine family amino acid metabolism (HP:0010894)3.23504176
71Hepatocellular carcinoma (HP:0001402)3.23431436
72Patellar aplasia (HP:0006443)3.18828603
73Squamous cell carcinoma (HP:0002860)3.18448113
74Delayed epiphyseal ossification (HP:0002663)3.15858465
75Short chin (HP:0000331)3.14662675
76Hypercholesterolemia (HP:0003124)3.14104820
77Skin nodule (HP:0200036)3.10812586
78Symptomatic seizures (HP:0011145)3.09580944
79Abnormality of fatty-acid metabolism (HP:0004359)3.09397904
80Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.08703062
81Myotonia (HP:0002486)3.02772426
82Hyperbilirubinemia (HP:0002904)3.01344182
83Increased intramyocellular lipid droplets (HP:0012240)3.01152658
84Exertional dyspnea (HP:0002875)3.00222273
85Aplasia/Hypoplasia of the patella (HP:0006498)2.95383252
86Anteriorly placed anus (HP:0001545)2.94805707
87Myocardial infarction (HP:0001658)2.90570066
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.90408941
89Increased muscle lipid content (HP:0009058)2.87853591
90Hyperglycemia (HP:0003074)2.83694470
91Abnormality of the costochondral junction (HP:0000919)2.82747131
92Abnormality of pyrimidine metabolism (HP:0004353)2.82214824
93Steatorrhea (HP:0002570)2.76307354
94Mitral stenosis (HP:0001718)2.76275734
95Zonular cataract (HP:0010920)2.74916601
96Neonatal respiratory distress (HP:0002643)2.73939297
97Enlarged kidneys (HP:0000105)2.70529467
98Vascular calcification (HP:0004934)2.70153465
99Abnormal urine phosphate concentration (HP:0012599)2.69394645
100Abnormality of nucleobase metabolism (HP:0010932)2.69299127
101Systemic lupus erythematosus (HP:0002725)2.69005199
102Cardiovascular calcification (HP:0011915)2.66752176
103Enlarged epiphyses (HP:0010580)2.65367298
104Spontaneous abortion (HP:0005268)2.63975653
105Abnormality of purine metabolism (HP:0004352)2.62841278
106Aplasia/Hypoplasia involving the musculature (HP:0001460)2.60619971
107Capillary hemangiomas (HP:0005306)2.60128068
108Abnormality of renal resorption (HP:0011038)2.59200527
109Delayed CNS myelination (HP:0002188)2.55838167
110Gout (HP:0001997)2.53338242
111Widely patent fontanelles and sutures (HP:0004492)2.51577320
112Joint stiffness (HP:0001387)2.50959499
113Respiratory difficulties (HP:0002880)2.46850143
114Pancreatic islet-cell hyperplasia (HP:0004510)2.45181650
115Generalized aminoaciduria (HP:0002909)2.43102782
116Bowed forearm bones (HP:0003956)2.42283401
117Bowing of the arm (HP:0006488)2.42283401
118Abnormality of serum amino acid levels (HP:0003112)2.41543205
119Late onset (HP:0003584)2.40193820
120Metabolic acidosis (HP:0001942)2.39416178
121Glomerulonephritis (HP:0000099)2.38114331
122Absent thumb (HP:0009777)2.37482246
123Choanal stenosis (HP:0000452)2.37201188
124Abnormality of the pancreatic islet cells (HP:0006476)2.34597252
125Abnormality of endocrine pancreas physiology (HP:0012093)2.34597252
126Increased number of teeth (HP:0011069)2.34093151
127Glycosuria (HP:0003076)2.29991518
128Abnormality of urine glucose concentration (HP:0011016)2.29991518
129Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29556961
130Dicarboxylic aciduria (HP:0003215)2.29556961
131Renal cortical cysts (HP:0000803)2.26859296
132Hypochromic microcytic anemia (HP:0004840)2.26510637
133Pterygium (HP:0001059)2.24576922
134Short humerus (HP:0005792)2.19962514
135Opisthotonus (HP:0002179)2.16268165
136Reduced antithrombin III activity (HP:0001976)2.16186573
137Renal tubular dysfunction (HP:0000124)2.13836104
138Menorrhagia (HP:0000132)2.13204147
139Pancreatitis (HP:0001733)2.10338158
140Birth length less than 3rd percentile (HP:0003561)2.09766171
141Gingival bleeding (HP:0000225)2.08957200
142Narrow nasal bridge (HP:0000446)2.06998919
143Diminished movement (HP:0002374)2.06843704
144Hyperphosphaturia (HP:0003109)2.04916983
145Esophageal varix (HP:0002040)2.04618169
146Acanthocytosis (HP:0001927)2.03925540
147Thin ribs (HP:0000883)2.03757360
148Premature graying of hair (HP:0002216)2.03660808
149Protrusio acetabuli (HP:0003179)2.03101674
150Abnormal gallbladder morphology (HP:0012437)2.03025793
151Macular degeneration (HP:0000608)2.02777088
152Malignant hyperthermia (HP:0002047)2.02316678
153Abnormal drinking behavior (HP:0030082)2.02146910
154Polydipsia (HP:0001959)2.02146910
155Lethargy (HP:0001254)2.00610924
156Aplasia/hypoplasia of the humerus (HP:0006507)1.99882286
157Heart block (HP:0012722)1.97360405
158Absent radius (HP:0003974)1.96846401
159Flat occiput (HP:0005469)1.93846204
160Long clavicles (HP:0000890)1.93256031
161Abnormal cartilage morphology (HP:0002763)1.92933103
162Sensorimotor neuropathy (HP:0007141)1.92812390
163Abnormality of the hepatic vasculature (HP:0006707)1.92291167
164Pendular nystagmus (HP:0012043)1.90886704
165Biconcave vertebral bodies (HP:0004586)1.90095472
166Abnormal enzyme/coenzyme activity (HP:0012379)1.89777898
167Amyloidosis (HP:0011034)1.89384720
168Hydroxyprolinuria (HP:0003080)1.88481240
169Abnormality of proline metabolism (HP:0010907)1.88481240
170Protuberant abdomen (HP:0001538)1.87119368
171Irritability (HP:0000737)1.87016706
172Cerebral palsy (HP:0100021)1.85870323
173Abnormal atrioventricular conduction (HP:0005150)1.85542998
174Absent forearm bone (HP:0003953)1.85335655
175Aplasia involving forearm bones (HP:0009822)1.85335655
176Hypoplasia of the pons (HP:0012110)1.82598128
177Nonimmune hydrops fetalis (HP:0001790)1.82534110
178Recurrent gram-negative bacterial infections (HP:0005420)1.81076515
179Cerebral edema (HP:0002181)1.79731955
180Thrombophlebitis (HP:0004418)1.79422227
181Elevated alkaline phosphatase (HP:0003155)1.78992607
182Cholelithiasis (HP:0001081)1.78058200
183Cheilitis (HP:0100825)1.78008121
184Rickets (HP:0002748)1.76956721
185Brushfield spots (HP:0001088)1.76756537
186Hemorrhage of the eye (HP:0011885)1.76013539
187Hypophosphatemic rickets (HP:0004912)1.75711959
188Type 2 muscle fiber atrophy (HP:0003554)1.75469489
189Small hand (HP:0200055)1.74822055
190Proximal tubulopathy (HP:0000114)1.74138111
191Insulin resistance (HP:0000855)1.73626195
192Nephritis (HP:0000123)1.73260537
193Vomiting (HP:0002013)1.72936469
194Neonatal onset (HP:0003623)1.72839881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.35664893
2INSRR4.93543674
3BCKDK4.17534531
4MUSK4.11933758
5SIK13.74090168
6TIE13.48286321
7ERN13.20373842
8TLK13.12493874
9TAOK33.09767461
10FGFR43.02746651
11STK162.93552943
12MAPK152.76991790
13BLK2.41551951
14FRK2.30077517
15MST1R2.24511665
16IRAK32.14275218
17PIK3CG2.03070259
18TGFBR22.03066026
19FLT31.99846396
20ADRBK21.89334070
21LATS11.88966384
22ACVR1B1.83001437
23NEK91.76859695
24AKT31.74153327
25ADRBK11.70169177
26ERBB41.69904861
27BMPR1B1.53858637
28WNK11.45353868
29TESK21.44503453
30MET1.41687241
31PTK61.39003813
32TRIB31.35026928
33EPHA31.30671249
34CAMK1D1.30461998
35FGFR21.26517934
36PINK11.23958048
37STK391.21205758
38KDR1.17806178
39CCNB11.16600800
40PKN21.15653610
41SIK21.14669457
42JAK11.14593060
43GRK11.13714623
44PDGFRA1.13527629
45MAPK111.10155708
46IRAK11.07030639
47PRKAA21.05994552
48NEK21.05174554
49TYK21.04653569
50DYRK1B1.03304229
51PDPK11.01394673
52ZAK0.99562763
53STK38L0.97953068
54TRIM280.97139801
55SGK20.97117074
56GRK60.94094201
57CDK60.92064020
58CDK150.91842300
59MAP3K30.91237315
60OXSR10.89527318
61PDK20.88840466
62CDK40.88680914
63NUAK10.88022069
64MAP2K60.86788029
65MAP2K30.85616422
66CDK180.85176168
67MYLK0.82787127
68CDK11A0.82754191
69SGK30.81758623
70MAP2K40.81063991
71PTK20.81034506
72JAK20.79588245
73EPHB20.78453307
74MAPK70.78230110
75CAMK1G0.78180887
76PRKD20.74772581
77PIK3CA0.73526524
78TEC0.73251616
79GSK3A0.71767193
80FGFR30.71470606
81MELK0.68029759
82MAP3K140.67847377
83MAP2K20.66308678
84NLK0.66258043
85PRKAA10.63900968
86BMX0.63596352
87EPHB10.63577316
88IGF1R0.61996553
89FER0.61899351
90PAK10.61673032
91TRPM70.61285925
92TGFBR10.59147595
93MAP3K70.57991213
94PLK10.57954192
95SGK4940.57718722
96SGK2230.57718722
97CSNK1D0.57594999
98WNK30.57223830
99ABL20.57025457
100CHEK20.56654255
101AURKA0.56403106
102CDK140.54442649
103GRK70.54241475
104PRKCE0.53939610
105ERBB20.53846253
106PASK0.53349883
107TBK10.52800420
108IRAK20.52763318
109STK110.52333963
110PRKACG0.51655477
111BRAF0.50596096
112RIPK10.50040154
113PHKG20.49733312
114PHKG10.49733312
115GRK50.48704324
116CHUK0.47283728
117IKBKE0.46455070
118DDR20.45944011
119BRSK20.45476463
120RPS6KA60.45221672
121MAP3K10.44653141
122HIPK20.44628046
123OBSCN0.44162014
124MTOR0.42769252
125ATR0.42670351
126PAK30.42124855
127PRKCH0.39860927
128ZAP700.39709935
129PRKD10.39419044
130IRAK40.39286086
131CAMK40.38807116
132CAMK2G0.38103593
133RPS6KA20.36735784
134MAPK80.36486655
135PRKCZ0.36286520
136MAP2K10.35859866
137EIF2AK20.35684556
138MAPK40.35343316
139MAPKAPK30.34954049
140DAPK20.34866069
141EPHA20.34078052
142MAPK120.34064834
143MAP3K60.33789170
144RPS6KA50.33379095
145PIM20.33208368
146CSK0.32788334
147PRKCQ0.31797530
148IKBKB0.31093497
149PRKCG0.29336417
150DYRK20.29314999
151PRKACA0.27944222
152STK380.26567943
153PRKCA0.23925989
154RPS6KL10.23027540
155RPS6KC10.23027540
156CDK10.22068590
157PBK0.20125487
158ARAF0.17037842
159BUB10.15742305
160PRKCD0.15010495

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.40772850
2Nitrogen metabolism_Homo sapiens_hsa009103.14746593
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.12028260
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.06821053
5Complement and coagulation cascades_Homo sapiens_hsa046102.91312008
6Tryptophan metabolism_Homo sapiens_hsa003802.85799593
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78102301
8Arginine biosynthesis_Homo sapiens_hsa002202.72058403
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52013164
10Fatty acid degradation_Homo sapiens_hsa000712.51477282
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48096052
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.37643599
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36144327
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24360355
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20776317
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18895286
17Sphingolipid metabolism_Homo sapiens_hsa006002.16204927
18Butanoate metabolism_Homo sapiens_hsa006502.12804846
19Peroxisome_Homo sapiens_hsa041462.11773400
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08045743
21PPAR signaling pathway_Homo sapiens_hsa033201.96439316
22Propanoate metabolism_Homo sapiens_hsa006401.88582093
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.88028520
24Histidine metabolism_Homo sapiens_hsa003401.87879621
25Fatty acid metabolism_Homo sapiens_hsa012121.87575338
26Chemical carcinogenesis_Homo sapiens_hsa052041.80569130
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80364512
28Sulfur metabolism_Homo sapiens_hsa009201.78402036
29Staphylococcus aureus infection_Homo sapiens_hsa051501.77434686
30Selenocompound metabolism_Homo sapiens_hsa004501.69484962
31beta-Alanine metabolism_Homo sapiens_hsa004101.67401289
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65689317
33Retinol metabolism_Homo sapiens_hsa008301.60707847
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.60658801
35Phenylalanine metabolism_Homo sapiens_hsa003601.56570628
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.56068772
37Tyrosine metabolism_Homo sapiens_hsa003501.55340092
38Caffeine metabolism_Homo sapiens_hsa002321.53258791
39Fatty acid elongation_Homo sapiens_hsa000621.52816137
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49794171
41Starch and sucrose metabolism_Homo sapiens_hsa005001.49626269
42ABC transporters_Homo sapiens_hsa020101.45965502
43Bile secretion_Homo sapiens_hsa049761.44157100
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38756469
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35640001
46Fanconi anemia pathway_Homo sapiens_hsa034601.28879585
47Hedgehog signaling pathway_Homo sapiens_hsa043401.26364656
48* Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25519986
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19725425
50Folate biosynthesis_Homo sapiens_hsa007901.18630807
51Pyruvate metabolism_Homo sapiens_hsa006201.15604224
52Fat digestion and absorption_Homo sapiens_hsa049751.10233650
53Steroid biosynthesis_Homo sapiens_hsa001001.07201017
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99794194
55Lysine degradation_Homo sapiens_hsa003100.97418458
56RNA polymerase_Homo sapiens_hsa030200.96895091
57Vitamin digestion and absorption_Homo sapiens_hsa049770.94257455
58Arginine and proline metabolism_Homo sapiens_hsa003300.94155666
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93814635
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93471195
61Taste transduction_Homo sapiens_hsa047420.90748463
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.88792962
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87144255
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87027002
65Vitamin B6 metabolism_Homo sapiens_hsa007500.84604404
66Carbon metabolism_Homo sapiens_hsa012000.84281289
67Biosynthesis of amino acids_Homo sapiens_hsa012300.80639452
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76007080
69Phototransduction_Homo sapiens_hsa047440.69290693
70Sulfur relay system_Homo sapiens_hsa041220.67277124
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62361866
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60722860
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59210948
74Protein export_Homo sapiens_hsa030600.58675644
75One carbon pool by folate_Homo sapiens_hsa006700.58590995
76Basal transcription factors_Homo sapiens_hsa030220.57884895
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.56767462
78Glycerolipid metabolism_Homo sapiens_hsa005610.54921205
79Prion diseases_Homo sapiens_hsa050200.54193517
80Homologous recombination_Homo sapiens_hsa034400.53098516
81Glutathione metabolism_Homo sapiens_hsa004800.51576467
82Nicotine addiction_Homo sapiens_hsa050330.50458767
83Fatty acid biosynthesis_Homo sapiens_hsa000610.50401485
84Hippo signaling pathway_Homo sapiens_hsa043900.50023724
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.49042891
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48899578
87Basal cell carcinoma_Homo sapiens_hsa052170.48133984
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46332033
89Insulin resistance_Homo sapiens_hsa049310.45022262
90Metabolic pathways_Homo sapiens_hsa011000.44536909
91Galactose metabolism_Homo sapiens_hsa000520.42173931
92Mineral absorption_Homo sapiens_hsa049780.41765689
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40044572
94Cocaine addiction_Homo sapiens_hsa050300.38500912
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35211078
96Pyrimidine metabolism_Homo sapiens_hsa002400.34438595
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30708035
98Calcium signaling pathway_Homo sapiens_hsa040200.30390463
99Non-homologous end-joining_Homo sapiens_hsa034500.29829557
100Fructose and mannose metabolism_Homo sapiens_hsa000510.27190036
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24348622
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.24290781
103Oxidative phosphorylation_Homo sapiens_hsa001900.23696454
104Glucagon signaling pathway_Homo sapiens_hsa049220.22778843
105Pentose phosphate pathway_Homo sapiens_hsa000300.21650054
106Linoleic acid metabolism_Homo sapiens_hsa005910.21395881
107Inositol phosphate metabolism_Homo sapiens_hsa005620.21213943
108Other glycan degradation_Homo sapiens_hsa005110.20960802
109Base excision repair_Homo sapiens_hsa034100.20450840
110Ovarian steroidogenesis_Homo sapiens_hsa049130.19957223
111ECM-receptor interaction_Homo sapiens_hsa045120.16633439
112Protein digestion and absorption_Homo sapiens_hsa049740.16293678
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.11558262
114Lysosome_Homo sapiens_hsa041420.11116108
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07736409
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06755595
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06015744
118Arachidonic acid metabolism_Homo sapiens_hsa005900.04921256
119AMPK signaling pathway_Homo sapiens_hsa041520.04833825
120N-Glycan biosynthesis_Homo sapiens_hsa005100.04237450
121Thyroid hormone synthesis_Homo sapiens_hsa049180.04201024
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01007682
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.00036512
124Insulin signaling pathway_Homo sapiens_hsa04910-0.0420724
125Circadian rhythm_Homo sapiens_hsa04710-0.0418036
126Amoebiasis_Homo sapiens_hsa05146-0.0357838
127Type II diabetes mellitus_Homo sapiens_hsa04930-0.0297144
128Regulation of autophagy_Homo sapiens_hsa04140-0.0249056

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »