GGH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)8.07759693
2intestinal cholesterol absorption (GO:0030299)7.40236461
3protein retention in ER lumen (GO:0006621)6.54091258
4digestion (GO:0007586)6.30069791
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.14484239
6signal peptide processing (GO:0006465)5.33943341
7regulation of phospholipase A2 activity (GO:0032429)4.94565475
8CENP-A containing nucleosome assembly (GO:0034080)4.82074094
9chromatin remodeling at centromere (GO:0031055)4.75076060
10positive regulation of heat generation (GO:0031652)4.44974834
11regulation of fever generation (GO:0031620)4.37806574
12proteasome assembly (GO:0043248)4.35220031
13transcytosis (GO:0045056)4.33192996
14glycolipid catabolic process (GO:0019377)4.31224922
15telomere maintenance via semi-conservative replication (GO:0032201)4.18194843
16neutrophil activation involved in immune response (GO:0002283)4.17347746
17membrane lipid catabolic process (GO:0046466)4.16656161
18DNA strand elongation involved in DNA replication (GO:0006271)4.12743936
19ceramide catabolic process (GO:0046514)4.08431571
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07787002
21mitotic metaphase plate congression (GO:0007080)4.07578448
22protein localization to kinetochore (GO:0034501)4.05754582
23DNA strand elongation (GO:0022616)4.02279764
24mitotic sister chromatid segregation (GO:0000070)4.02106842
25establishment of integrated proviral latency (GO:0075713)4.01635574
26cobalamin metabolic process (GO:0009235)3.86344005
27L-serine metabolic process (GO:0006563)3.85834431
28cullin deneddylation (GO:0010388)3.84645258
29histone exchange (GO:0043486)3.84625980
30neutrophil mediated immunity (GO:0002446)3.80145519
31sister chromatid segregation (GO:0000819)3.79358607
32regulation of heat generation (GO:0031650)3.76921041
33kinetochore organization (GO:0051383)3.75559564
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75090212
35DNA replication-independent nucleosome organization (GO:0034724)3.72748447
36DNA replication-independent nucleosome assembly (GO:0006336)3.72748447
37mitochondrial calcium ion transport (GO:0006851)3.70337757
38metaphase plate congression (GO:0051310)3.69428027
39protein deneddylation (GO:0000338)3.65205390
40mitotic recombination (GO:0006312)3.60355382
41protein localization to chromosome, centromeric region (GO:0071459)3.58913346
42telomere maintenance via recombination (GO:0000722)3.53045415
43DNA ligation (GO:0006266)3.52542368
44DNA replication checkpoint (GO:0000076)3.50604100
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45245151
46kinetochore assembly (GO:0051382)3.43059006
47cholesterol catabolic process (GO:0006707)3.39778758
48sterol catabolic process (GO:0016127)3.39778758
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39541192
50mitotic chromosome condensation (GO:0007076)3.38600201
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38266565
52establishment of viral latency (GO:0019043)3.33570846
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.28274307
54glyoxylate metabolic process (GO:0046487)3.22513808
55deoxyribonucleotide biosynthetic process (GO:0009263)3.22365105
56regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22135759
57leukotriene biosynthetic process (GO:0019370)3.22111976
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20888864
59regulation of mitochondrial translation (GO:0070129)3.15171777
60DNA unwinding involved in DNA replication (GO:0006268)3.14507542
61intestinal absorption (GO:0050892)3.12651430
62serine family amino acid biosynthetic process (GO:0009070)3.12568828
63response to peptidoglycan (GO:0032494)3.11539860
64leukotriene metabolic process (GO:0006691)3.10441670
65establishment of chromosome localization (GO:0051303)3.09445095
66negative regulation of ligase activity (GO:0051352)3.09302211
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09302211
68spindle checkpoint (GO:0031577)3.07538120
69sphingolipid catabolic process (GO:0030149)3.02026055
70myeloid leukocyte mediated immunity (GO:0002444)3.00277729
71branched-chain amino acid catabolic process (GO:0009083)3.00060921
72purine nucleobase biosynthetic process (GO:0009113)2.99421308
73glycine metabolic process (GO:0006544)2.99126553
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96970797
75chaperone-mediated protein transport (GO:0072321)2.92162239
76regulation of chromosome segregation (GO:0051983)2.91747862
77amyloid precursor protein catabolic process (GO:0042987)2.91340164
78telomere maintenance via telomere lengthening (GO:0010833)2.91274190
79peptidyl-proline hydroxylation (GO:0019511)2.91057599
80production of molecular mediator involved in inflammatory response (GO:0002532)2.89187577
81mitotic spindle checkpoint (GO:0071174)2.89177160
82establishment of protein localization to mitochondrial membrane (GO:0090151)2.87257885
83response to interferon-beta (GO:0035456)2.84975012
84regulation of double-strand break repair via homologous recombination (GO:0010569)2.84893874
85negative regulation of digestive system process (GO:0060457)2.83377438
86negative regulation of mitotic sister chromatid separation (GO:2000816)2.81357955
87negative regulation of sister chromatid segregation (GO:0033046)2.81357955
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81357955
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81357955
90negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81357955
91DNA replication initiation (GO:0006270)2.81128411
92negative regulation of chromosome segregation (GO:0051985)2.80876887
93protein K6-linked ubiquitination (GO:0085020)2.80771709
94regulation of chemokine secretion (GO:0090196)2.80751482
95chromosome segregation (GO:0007059)2.80452014
96DNA replication-dependent nucleosome assembly (GO:0006335)2.80159274
97DNA replication-dependent nucleosome organization (GO:0034723)2.80159274
98regulation of centriole replication (GO:0046599)2.79690776
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.79461058
100DNA double-strand break processing (GO:0000729)2.79150615
101neutrophil activation (GO:0042119)2.78936871
102positive regulation of monocyte chemotaxis (GO:0090026)2.78467842
103regulation of cellular amino acid metabolic process (GO:0006521)2.78405434
104cellular response to interferon-beta (GO:0035458)2.78346030
105DNA damage response, detection of DNA damage (GO:0042769)2.77126771
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76561951
107double-strand break repair via nonhomologous end joining (GO:0006303)2.75542259
108non-recombinational repair (GO:0000726)2.75542259
109desmosome organization (GO:0002934)2.75500119
110mitotic spindle assembly checkpoint (GO:0007094)2.75332586
111spindle assembly checkpoint (GO:0071173)2.74370633
112purinergic nucleotide receptor signaling pathway (GO:0035590)2.74069524
113Golgi transport vesicle coating (GO:0048200)2.73962840
114COPI coating of Golgi vesicle (GO:0048205)2.73962840
115positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.72780978
116granulocyte activation (GO:0036230)2.72697996
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71803081
118antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71803081
119cell cycle G1/S phase transition (GO:0044843)2.69348134
120G1/S transition of mitotic cell cycle (GO:0000082)2.69348134
121protein maturation by protein folding (GO:0022417)2.67919011
122valine metabolic process (GO:0006573)2.67516267
123GDP-mannose metabolic process (GO:0019673)2.66969836
124aldehyde catabolic process (GO:0046185)2.66903918
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66014682
126regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.66014682
127resolution of meiotic recombination intermediates (GO:0000712)2.65463991
128ventricular cardiac muscle cell development (GO:0055015)2.64705824
129replication fork processing (GO:0031297)2.64046932
130sphingoid metabolic process (GO:0046519)2.63397857
131nucleobase-containing small molecule interconversion (GO:0015949)2.62919032
132branched-chain amino acid metabolic process (GO:0009081)2.62211473
133detection of other organism (GO:0098543)2.61950561
134regulation of ubiquitin-protein transferase activity (GO:0051438)2.61854045
135DNA topological change (GO:0006265)2.60801320
136serine family amino acid metabolic process (GO:0009069)2.60798382
137positive regulation of ligase activity (GO:0051351)2.60457235
138regulation of spindle organization (GO:0090224)2.59745154
139regulation of mitotic spindle organization (GO:0060236)2.59176713
140signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.59102148
141signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.59102148
142signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.59102148
143DNA catabolic process, exonucleolytic (GO:0000738)2.58205504
144transcription-coupled nucleotide-excision repair (GO:0006283)2.57456283
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.57362037
146intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.57362037
147DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.57348998
148protein localization to chromosome (GO:0034502)2.57077088
149positive regulation of chemokine secretion (GO:0090197)2.56874978
150positive regulation of interferon-alpha production (GO:0032727)2.56650194
151mitotic cell cycle (GO:0000278)2.56487942
152ribosome assembly (GO:0042255)2.55989226
153regulation of mitotic sister chromatid segregation (GO:0033047)2.55786123
154antigen processing and presentation of endogenous antigen (GO:0019883)2.52931456
155respiratory burst (GO:0045730)2.52062659
156positive regulation of antigen processing and presentation (GO:0002579)2.51102663
157positive regulation by symbiont of host defense response (GO:0052509)2.49692700
158modulation by symbiont of host defense response (GO:0052031)2.49692700
159modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49692700
160modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49692700
161positive regulation by organism of defense response of other organism involved in symbiotic interact2.49692700
162modulation by symbiont of host immune response (GO:0052553)2.49692700
163leukocyte aggregation (GO:0070486)2.48615789
164lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48243783
165proline biosynthetic process (GO:0006561)2.48234895
166regulation of interferon-beta biosynthetic process (GO:0045357)2.47226121
167hydrogen peroxide biosynthetic process (GO:0050665)2.44492969
168ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.44238133
169cellular response to type I interferon (GO:0071357)2.43437561
170type I interferon signaling pathway (GO:0060337)2.43437561
171peptide catabolic process (GO:0043171)2.42991394
172response to type I interferon (GO:0034340)2.41957497
173regulation of interferon-alpha production (GO:0032647)2.40541628
174superoxide anion generation (GO:0042554)2.40358641
175positive regulation of chemokine biosynthetic process (GO:0045080)2.38838721
176cysteine metabolic process (GO:0006534)2.38098198
177regulation of activation of Janus kinase activity (GO:0010533)2.36310686
178cellular response to exogenous dsRNA (GO:0071360)2.35748555
179positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.34646937
180glucosamine-containing compound catabolic process (GO:1901072)2.33848212
181antibacterial humoral response (GO:0019731)2.32727858
182sphingosine metabolic process (GO:0006670)2.32724143
183negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.31202687
184antimicrobial humoral response (GO:0019730)2.29203551
185T-helper 1 type immune response (GO:0042088)2.28130716
186reactive oxygen species biosynthetic process (GO:1903409)2.27049200
187positive regulation of cellular amide metabolic process (GO:0034250)2.26857590
188positive regulation of acute inflammatory response (GO:0002675)2.26489120
189regulation of antigen processing and presentation (GO:0002577)2.26287256
190positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.25663326
191I-kappaB phosphorylation (GO:0007252)2.25057944
192regulation of hypersensitivity (GO:0002883)2.23311383
193response to endoplasmic reticulum stress (GO:0034976)2.22956720
194membrane protein intracellular domain proteolysis (GO:0031293)2.22857458
195regulation of chemokine biosynthetic process (GO:0045073)2.22743694
196positive regulation of T cell migration (GO:2000406)2.22029202
197intestinal epithelial cell development (GO:0060576)2.21553148
198regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.19199984
199immunoglobulin mediated immune response (GO:0016064)2.19108402
200regulation of interleukin-8 secretion (GO:2000482)2.18434706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.00418379
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.27647848
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.07172737
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.66197053
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.41050583
6FOXM1_23109430_ChIP-Seq_U2OS_Human4.20311416
7E2F4_17652178_ChIP-ChIP_JURKAT_Human4.07366201
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.55813126
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.54364789
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.44525621
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.32774870
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21805178
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.20825211
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.19263605
15AR_21909140_ChIP-Seq_LNCAP_Human3.14388780
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.01027946
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95415334
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.91748080
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81323796
20* IRF8_27001747_Chip-Seq_BMDM_Mouse2.74132916
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.72152792
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68171818
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65731386
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60083993
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.55718623
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49160016
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47240621
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45324344
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43621350
30ELK1_19687146_ChIP-ChIP_HELA_Human2.42710479
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42304139
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.40521163
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34282256
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31841219
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26717081
36DCP1A_22483619_ChIP-Seq_HELA_Human2.25738997
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22729724
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22440449
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22251095
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22204908
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14629637
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10616822
43E2F1_21310950_ChIP-Seq_MCF-7_Human2.10407412
44THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07670293
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06121917
46MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06118392
47* SOX2_20726797_ChIP-Seq_SW620_Human2.01023585
48P63_26484246_Chip-Seq_KERATINOCYTES_Human1.98768058
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97340333
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.95424053
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.94693144
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90507918
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89641943
54GABP_19822575_ChIP-Seq_HepG2_Human1.88828674
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81582987
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79998668
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79415474
58* TTF2_22483619_ChIP-Seq_HELA_Human1.78660095
59VDR_23849224_ChIP-Seq_CD4+_Human1.76855238
60XRN2_22483619_ChIP-Seq_HELA_Human1.75057895
61* GATA4_25053715_ChIP-Seq_YYC3_Human1.74550973
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.73678911
63* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73484914
64FOXP3_21729870_ChIP-Seq_TREG_Human1.72196462
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71180681
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70897917
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68811947
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65693484
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63768340
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63502972
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61065465
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59306052
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57382139
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56903076
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56796212
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56400377
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55977131
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55605686
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51449984
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49674013
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.48465315
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46345394
83EGR1_19032775_ChIP-ChIP_M12_Human1.45660663
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44662338
85PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42632130
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41644593
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41066706
88RUNX_20019798_ChIP-Seq_JUKART_Human1.40122477
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39972611
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39972611
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.37766935
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37191584
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36914086
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34302044
95SPI1_23547873_ChIP-Seq_NB4_Human1.32021549
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31802104
97RXR_22158963_ChIP-Seq_LIVER_Mouse1.31460468
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29765857
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29728319
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29609034
101ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29034437
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27942186
103MYC_18940864_ChIP-ChIP_HL60_Human1.27910276
104GATA1_22025678_ChIP-Seq_K562_Human1.26982937
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25055851
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24782164
107CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24688563
108SOX17_20123909_ChIP-Seq_XEN_Mouse1.24623355
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24051185
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23367986
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19771613
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19302385
113GATA2_21666600_ChIP-Seq_HMVEC_Human1.19043195
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18803732
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18803732
116LXR_22158963_ChIP-Seq_LIVER_Mouse1.18443146
117MYB_26560356_Chip-Seq_TH2_Human1.17983483
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17590825
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17590825
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17590825
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16322196
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15494700
123VDR_24787735_ChIP-Seq_THP-1_Human1.15201456
124NANOG_16153702_ChIP-ChIP_HESCs_Human1.14056024
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13681349
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13595481
127YY1_21170310_ChIP-Seq_MESCs_Mouse1.13400161
128EWS_26573619_Chip-Seq_HEK293_Human1.13335361
129SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10921228
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10470835
131CJUN_26792858_Chip-Seq_BT549_Human1.10122246
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09321233
133PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08899791
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07757245
135FOXO3_23340844_ChIP-Seq_DLD1_Human1.05019297
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04726347
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03266602
138* CDX2_20551321_ChIP-Seq_CACO-2_Human1.02188812
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01958463
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01426150
141FUS_26573619_Chip-Seq_HEK293_Human1.00947008
142MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99906219
143PU_27001747_Chip-Seq_BMDM_Mouse0.99319236
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98173440
145CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98132670
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97625968
147HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97155244
148KDM5A_27292631_Chip-Seq_BREAST_Human0.96913405
149SOX2_16153702_ChIP-ChIP_HESCs_Human0.96152723
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95315775
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94858605
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94204670
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93881517
154CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93647861
155ZNF263_19887448_ChIP-Seq_K562_Human0.93329510
156TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92981961
157POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91920240
158ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91258553
159GATA3_24758297_ChIP-Seq_MCF-7_Human0.91083040
160* GATA6_25053715_ChIP-Seq_YYC3_Human0.90469988
161SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90172667
162ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88754312
163* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88749866
164E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88615667
165SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88334405
166IRF1_19129219_ChIP-ChIP_H3396_Human0.88184772
167CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87745454
168CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87582569
169IGF1R_20145208_ChIP-Seq_DFB_Human0.87423544
170RUNX1_22412390_ChIP-Seq_EML_Mouse0.87392537
171AR_20517297_ChIP-Seq_VCAP_Human0.85929625
172STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83112764
173TP53_18474530_ChIP-ChIP_U2OS_Human0.82854683
174GATA3_26560356_Chip-Seq_TH2_Human0.82424230
175TP63_23658742_ChIP-Seq_EP156T_Human0.80789101
176CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80467663
177JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80308837
178ZNF274_21170338_ChIP-Seq_K562_Hela0.79940249
179POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79481598
180KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79057935
181ELK1_22589737_ChIP-Seq_MCF10A_Human0.78929813
182DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78418263
183SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77626834
184KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76441593
185ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75846949
186NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75512047
187DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73071250
188RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72246200
189HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.69361578
190ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68945779
191FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.68444675
192SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.65946870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption5.14179007
2MP0005083_abnormal_biliary_tract4.97999120
3MP0010094_abnormal_chromosome_stability3.81852617
4MP0005220_abnormal_exocrine_pancreas3.63046585
5MP0003693_abnormal_embryo_hatching3.41494028
6MP0009697_abnormal_copulation3.34285735
7MP0005365_abnormal_bile_salt3.24195171
8MP0004957_abnormal_blastocyst_morpholog3.00268002
9MP0008058_abnormal_DNA_repair3.00130383
10MP0003111_abnormal_nucleus_morphology2.97145917
11MP0008932_abnormal_embryonic_tissue2.80892929
12MP0003077_abnormal_cell_cycle2.72657568
13MP0002148_abnormal_hypersensitivity_rea2.69689596
14MP0001835_abnormal_antigen_presentation2.60282965
15MP0005084_abnormal_gallbladder_morpholo2.57574564
16MP0010030_abnormal_orbit_morphology2.55018479
17MP0009785_altered_susceptibility_to2.52572979
18MP0003436_decreased_susceptibility_to2.42926830
19MP0005058_abnormal_lysosome_morphology2.40474006
20MP0006082_CNS_inflammation2.38407638
21MP0003806_abnormal_nucleotide_metabolis2.33905752
22MP0002938_white_spotting2.31539968
23MP0002139_abnormal_hepatobiliary_system2.26952308
24MP0003724_increased_susceptibility_to2.22800120
25MP0006292_abnormal_olfactory_placode2.15551886
26MP0000372_irregular_coat_pigmentation2.15243960
27MP0003718_maternal_effect2.14421044
28MP0003868_abnormal_feces_composition2.05002571
29MP0002277_abnormal_respiratory_mucosa2.04452765
30MP0008007_abnormal_cellular_replicative2.01112836
31MP0001293_anophthalmia1.99558556
32MP0002796_impaired_skin_barrier1.97806521
33MP0002419_abnormal_innate_immunity1.95264440
34MP0005000_abnormal_immune_tolerance1.93101723
35MP0010234_abnormal_vibrissa_follicle1.93077542
36MP0005171_absent_coat_pigmentation1.84516780
37MP0005025_abnormal_response_to1.82088134
38MP0001529_abnormal_vocalization1.78004567
39MP0002693_abnormal_pancreas_physiology1.72500848
40MP0004947_skin_inflammation1.69742404
41MP0005085_abnormal_gallbladder_physiolo1.67746700
42MP0003186_abnormal_redox_activity1.66700437
43MP0002009_preneoplasia1.65189129
44MP0008789_abnormal_olfactory_epithelium1.62211116
45MP0008438_abnormal_cutaneous_collagen1.58990044
46MP0008004_abnormal_stomach_pH1.58555898
47MP0005671_abnormal_response_to1.57798454
48MP0001845_abnormal_inflammatory_respons1.57482911
49MP0003453_abnormal_keratinocyte_physiol1.55059252
50MP0002006_tumorigenesis1.54609143
51MP0000685_abnormal_immune_system1.54258895
52MP0005360_urolithiasis1.54252847
53MP0001533_abnormal_skeleton_physiology1.52973741
54MP0001873_stomach_inflammation1.51269537
55MP0003937_abnormal_limbs/digits/tail_de1.50695366
56MP0003941_abnormal_skin_development1.50043439
57MP0003890_abnormal_embryonic-extraembry1.49726543
58MP0005387_immune_system_phenotype1.48255716
59MP0001790_abnormal_immune_system1.48255716
60MP0002723_abnormal_immune_serum1.43033963
61MP0002098_abnormal_vibrissa_morphology1.42094151
62MP0002452_abnormal_antigen_presenting1.41547270
63MP0002060_abnormal_skin_morphology1.41313623
64MP0002254_reproductive_system_inflammat1.40988600
65MP0005275_abnormal_skin_tensile1.40128759
66MP0002234_abnormal_pharynx_morphology1.37917937
67MP0005451_abnormal_body_composition1.37183494
68MP0009764_decreased_sensitivity_to1.36172777
69MP0002233_abnormal_nose_morphology1.35758696
70MP0006054_spinal_hemorrhage1.34254977
71MP0003959_abnormal_lean_body1.32910807
72MP0001664_abnormal_digestion1.31724059
73MP0005394_taste/olfaction_phenotype1.31573615
74MP0005499_abnormal_olfactory_system1.31573615
75MP0010155_abnormal_intestine_physiology1.30956622
76MP0002697_abnormal_eye_size1.29924501
77MP0004381_abnormal_hair_follicle1.28156548
78MP0001800_abnormal_humoral_immune1.26626425
79MP0008469_abnormal_protein_level1.26553568
80MP0002420_abnormal_adaptive_immunity1.25813773
81MP0000358_abnormal_cell_content/1.25773345
82MP0001819_abnormal_immune_cell1.23980550
83MP0008875_abnormal_xenobiotic_pharmacok1.22050878
84MP0002405_respiratory_system_inflammati1.21972252
85MP0002102_abnormal_ear_morphology1.21676060
86MP0003121_genomic_imprinting1.21069137
87MP0001216_abnormal_epidermal_layer1.20822847
88MP0003786_premature_aging1.20822715
89MP0008057_abnormal_DNA_replication1.20542921
90MP0002166_altered_tumor_susceptibility1.19345970
91MP0003638_abnormal_response/metabolism_1.19283497
92MP0001697_abnormal_embryo_size1.18635445
93MP0000858_altered_metastatic_potential1.18266193
94MP0005187_abnormal_penis_morphology1.17971886
95MP0002282_abnormal_trachea_morphology1.16575619
96MP0001853_heart_inflammation1.16180238
97MP0005248_abnormal_Harderian_gland1.15976108
98MP0005464_abnormal_platelet_physiology1.15300324
99MP0009053_abnormal_anal_canal1.15065344
100MP0006035_abnormal_mitochondrial_morpho1.14351440
101MP0001730_embryonic_growth_arrest1.13874571
102MP0005165_increased_susceptibility_to1.13189542
103MP0001764_abnormal_homeostasis1.13065958
104MP0000350_abnormal_cell_proliferation1.09353554
105MP0001851_eye_inflammation1.09163109
106MP0002090_abnormal_vision1.08848384
107MP0003122_maternal_imprinting1.08091192
108MP0001286_abnormal_eye_development1.07963276
109MP0003123_paternal_imprinting1.07912987
110MP0000490_abnormal_crypts_of1.07317943
111MP0002092_abnormal_eye_morphology1.06542740
112MP0002085_abnormal_embryonic_tissue1.05768885
113MP0003755_abnormal_palate_morphology1.05700295
114MP0000566_synostosis1.04998814
115MP0005501_abnormal_skin_physiology1.04895519
116MP0003315_abnormal_perineum_morphology1.03881540
117MP0005408_hypopigmentation1.03834814
118MP0005380_embryogenesis_phenotype1.03590144
119MP0001672_abnormal_embryogenesis/_devel1.03590144
120MP0002998_abnormal_bone_remodeling1.02979064
121MP0005310_abnormal_salivary_gland1.02976288
122MP0004272_abnormal_basement_membrane1.02803033
123MP0004782_abnormal_surfactant_physiolog1.01205940
124MP0002084_abnormal_developmental_patter1.00943310
125MP0003191_abnormal_cellular_cholesterol1.00743237
126MP0005257_abnormal_intraocular_pressure1.00446891
127MP0010678_abnormal_skin_adnexa1.00322205
128MP0000465_gastrointestinal_hemorrhage0.98676522
129MP0005623_abnormal_meninges_morphology0.98412094
130MP0003195_calcinosis0.98154628
131MP0001663_abnormal_digestive_system0.97585041
132MP0000383_abnormal_hair_follicle0.96488909
133MP0003448_altered_tumor_morphology0.95868100
134MP0009379_abnormal_foot_pigmentation0.95081829
135MP0003303_peritoneal_inflammation0.94614901
136MP0000647_abnormal_sebaceous_gland0.94466287
137MP0002210_abnormal_sex_determination0.94352887
138MP0003705_abnormal_hypodermis_morpholog0.94326427
139MP0003075_altered_response_to0.93832298
140MP0006036_abnormal_mitochondrial_physio0.93080554
141MP0000377_abnormal_hair_follicle0.93028691
142MP0003183_abnormal_peptide_metabolism0.92990369
143MP0000049_abnormal_middle_ear0.92682070
144MP0003567_abnormal_fetal_cardiomyocyte0.92310766
145MP0001929_abnormal_gametogenesis0.92265106
146MP0002080_prenatal_lethality0.92091987
147MP0002138_abnormal_hepatobiliary_system0.91788366
148MP0009384_cardiac_valve_regurgitation0.91678013
149MP0003385_abnormal_body_wall0.91267664
150MP0009643_abnormal_urine_homeostasis0.91008697
151MP0001324_abnormal_eye_pigmentation0.90741180
152MP0004147_increased_porphyrin_level0.90463787
153MP0003795_abnormal_bone_structure0.89260324
154MP0010368_abnormal_lymphatic_system0.88932544
155MP0004264_abnormal_extraembryonic_tissu0.88348785
156MP0005390_skeleton_phenotype0.87756576
157MP0002933_joint_inflammation0.86711062
158MP0002736_abnormal_nociception_after0.85579043
159MP0005395_other_phenotype0.84448976
160MP0003690_abnormal_glial_cell0.83506498
161MP0005197_abnormal_uvea_morphology0.83369231
162MP0003252_abnormal_bile_duct0.83100045
163MP0003172_abnormal_lysosome_physiology0.82944693
164MP0009333_abnormal_splenocyte_physiolog0.82858031
165MP0002111_abnormal_tail_morphology0.82341022
166MP0003119_abnormal_digestive_system0.81649461
167MP0000537_abnormal_urethra_morphology0.81430664
168MP0003136_yellow_coat_color0.80830044
169MP0000470_abnormal_stomach_morphology0.80788496
170MP0000343_altered_response_to0.80726056
171MP0010771_integument_phenotype0.80549284
172MP0006072_abnormal_retinal_apoptosis0.80284940
173MP0005391_vision/eye_phenotype0.79900944
174MP0000653_abnormal_sex_gland0.79725043
175MP0003984_embryonic_growth_retardation0.78930402
176MP0002877_abnormal_melanocyte_morpholog0.78911234
177MP0002118_abnormal_lipid_homeostasis0.78517167
178MP0001944_abnormal_pancreas_morphology0.77298468
179MP0000762_abnormal_tongue_morphology0.77178732
180MP0009672_abnormal_birth_weight0.76173346
181MP0001145_abnormal_male_reproductive0.75542491
182MP0005166_decreased_susceptibility_to0.75454708
183MP0003763_abnormal_thymus_physiology0.75162592
184MP0002088_abnormal_embryonic_growth/wei0.74625147
185MP0003950_abnormal_plasma_membrane0.73174798
186MP0002160_abnormal_reproductive_system0.72994241
187MP0002095_abnormal_skin_pigmentation0.69038417
188MP0000778_abnormal_nervous_system0.68604680
189MP0002751_abnormal_autonomic_nervous0.68377696

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.11199195
2Steatorrhea (HP:0002570)4.62007820
3Recurrent abscess formation (HP:0002722)4.21880311
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.09684074
5Increased serum pyruvate (HP:0003542)4.06650979
6Eczematoid dermatitis (HP:0000976)4.06602338
7Abnormality of glycolysis (HP:0004366)4.03253154
8Recurrent bacterial skin infections (HP:0005406)3.91638124
9Chromsome breakage (HP:0040012)3.83076006
10Fat malabsorption (HP:0002630)3.59519323
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.55053711
12Meckel diverticulum (HP:0002245)3.35839494
13Dysostosis multiplex (HP:0000943)3.33478557
14Abnormality of macrophages (HP:0004311)3.29897974
15Increased cerebral lipofuscin (HP:0011813)3.27969409
16Hyperglycinemia (HP:0002154)3.20891202
17Acute encephalopathy (HP:0006846)3.20195960
18Recurrent gram-negative bacterial infections (HP:0005420)3.17978701
19Abnormality of the ileum (HP:0001549)3.16058889
20Elevated erythrocyte sedimentation rate (HP:0003565)3.10250780
21Systemic lupus erythematosus (HP:0002725)3.06944658
22Acute necrotizing encephalopathy (HP:0006965)3.01589755
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.00671557
24Abnormal lung lobation (HP:0002101)2.96051399
25Type I diabetes mellitus (HP:0100651)2.87838354
26Abnormal mitochondria in muscle tissue (HP:0008316)2.87556517
27Reduced antithrombin III activity (HP:0001976)2.85592744
28Abnormality of the preputium (HP:0100587)2.81379218
29Onycholysis (HP:0001806)2.80924150
30Joint stiffness (HP:0001387)2.78024077
31Myositis (HP:0100614)2.74262468
32Abnormality of chromosome stability (HP:0003220)2.73768866
33Hypobetalipoproteinemia (HP:0003563)2.72764823
34Decreased subcutaneous fat (HP:0001002)2.70904165
35Exocrine pancreatic insufficiency (HP:0001738)2.69343171
36Urinary glycosaminoglycan excretion (HP:0003541)2.67598545
37Mucopolysacchariduria (HP:0008155)2.67598545
38Cerebral edema (HP:0002181)2.67246091
39Degeneration of anterior horn cells (HP:0002398)2.67137013
40Abnormality of the anterior horn cell (HP:0006802)2.67137013
41Abnormality of the intrinsic pathway (HP:0010989)2.66404702
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.66336368
43Orchitis (HP:0100796)2.59934808
44Abnormality of subcutaneous fat tissue (HP:0001001)2.59913962
45Duodenal stenosis (HP:0100867)2.58776890
46Small intestinal stenosis (HP:0012848)2.58776890
47Urticaria (HP:0001025)2.58368770
48Parakeratosis (HP:0001036)2.53726666
49Periodontitis (HP:0000704)2.53432834
50Pancreatitis (HP:0001733)2.52417873
51Increased CSF lactate (HP:0002490)2.50826020
52Abnormal gallbladder physiology (HP:0012438)2.50413090
53Cholecystitis (HP:0001082)2.50413090
54Increased hepatocellular lipid droplets (HP:0006565)2.50005689
55Beaking of vertebral bodies (HP:0004568)2.49704339
56Premature loss of primary teeth (HP:0006323)2.47251660
57Abnormality of serum amino acid levels (HP:0003112)2.43999983
58Hypoplastic pelvis (HP:0008839)2.42515287
59Petechiae (HP:0000967)2.42335614
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.41169762
61Abnormal protein N-linked glycosylation (HP:0012347)2.41169762
62Abnormal protein glycosylation (HP:0012346)2.41169762
63Abnormal glycosylation (HP:0012345)2.41169762
64Axonal loss (HP:0003447)2.40838911
65Retrobulbar optic neuritis (HP:0100654)2.40579052
66Optic neuritis (HP:0100653)2.40579052
67Abnormality of methionine metabolism (HP:0010901)2.40420585
68Type I transferrin isoform profile (HP:0003642)2.40037906
69Mitochondrial inheritance (HP:0001427)2.40002755
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39854734
71Stomatitis (HP:0010280)2.38107417
72Autoimmune thrombocytopenia (HP:0001973)2.35289026
73Plantar hyperkeratosis (HP:0007556)2.34731493
74Autoimmune hemolytic anemia (HP:0001890)2.34418103
75Abnormality of polysaccharide metabolism (HP:0011012)2.34037346
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34037346
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34037346
78Abnormality of the labia minora (HP:0012880)2.33745672
79Mediastinal lymphadenopathy (HP:0100721)2.29738346
80Premature skin wrinkling (HP:0100678)2.29161701
81Reticulocytopenia (HP:0001896)2.28106818
82Interstitial pulmonary disease (HP:0006530)2.27884942
83Abnormality of the duodenum (HP:0002246)2.27478449
84Progressive macrocephaly (HP:0004481)2.27355826
85Abnormality of liposaccharide metabolism (HP:0010968)2.25026490
86Abnormality of glycosphingolipid metabolism (HP:0004343)2.25026490
87Abnormality of glycolipid metabolism (HP:0010969)2.25026490
88Cortical dysplasia (HP:0002539)2.24871667
89Lipid accumulation in hepatocytes (HP:0006561)2.24828462
90Vascular calcification (HP:0004934)2.24277318
91Anhidrosis (HP:0000970)2.22085884
92Abnormality of the lumbar spine (HP:0100712)2.22041062
93Increased nuchal translucency (HP:0010880)2.22030564
94Hypoproteinemia (HP:0003075)2.21523084
95Erythema (HP:0010783)2.20379493
96Microglossia (HP:0000171)2.20212968
97Recurrent skin infections (HP:0001581)2.19509694
98Myocardial infarction (HP:0001658)2.18373988
99Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.16898636
100Abnormality of serine family amino acid metabolism (HP:0010894)2.15901674
101Abnormality of glycine metabolism (HP:0010895)2.15901674
102Progressive neurologic deterioration (HP:0002344)2.13629600
103Bifid tongue (HP:0010297)2.13287445
104Pustule (HP:0200039)2.12710259
105Prolonged partial thromboplastin time (HP:0003645)2.12678694
106Short chin (HP:0000331)2.12089342
107Hepatocellular necrosis (HP:0001404)2.11058283
108Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08905639
109Poor head control (HP:0002421)2.08625463
110Hepatosplenomegaly (HP:0001433)2.08484501
111Abnormality of the fetal cardiovascular system (HP:0010948)2.08239594
112Abnormal umbilical cord blood vessels (HP:0011403)2.08239594
113Single umbilical artery (HP:0001195)2.08239594
114Congenital ichthyosiform erythroderma (HP:0007431)2.07653268
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.06774223
116Hepatic necrosis (HP:0002605)2.05250816
117Gingivitis (HP:0000230)2.05193532
118Hypoplasia of the uterus (HP:0000013)2.05083853
119Cardiovascular calcification (HP:0011915)2.04882928
120Birth length less than 3rd percentile (HP:0003561)2.04150116
121Increased serum lactate (HP:0002151)2.04142236
122Colon cancer (HP:0003003)2.03488842
123Adrenal hypoplasia (HP:0000835)2.03224372
124Glomerulonephritis (HP:0000099)2.01772033
125Disinhibition (HP:0000734)2.01636974
126Deep venous thrombosis (HP:0002625)1.99669888
127Intrahepatic cholestasis (HP:0001406)1.99461376
128Palmoplantar hyperkeratosis (HP:0000972)1.99054838
129Short tibia (HP:0005736)1.98535052
130Facial cleft (HP:0002006)1.98130872
131Thick nail (HP:0001805)1.98103843
132Triphalangeal thumb (HP:0001199)1.97198746
133Maternal diabetes (HP:0009800)1.97024864
134Abnormality of the carotid arteries (HP:0005344)1.96414668
135Hypergammaglobulinemia (HP:0010702)1.94599570
136Popliteal pterygium (HP:0009756)1.93407212
137Vasculitis (HP:0002633)1.93033821
138Volvulus (HP:0002580)1.92648991
139Abnormality of the pons (HP:0007361)1.90563145
140Postnatal microcephaly (HP:0005484)1.90390448
141Abnormality of pyrimidine metabolism (HP:0004353)1.90278880
142Dry hair (HP:0011359)1.90144630
143Sloping forehead (HP:0000340)1.89785257
144Absent radius (HP:0003974)1.88349725
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87704936
146Lactic acidosis (HP:0003128)1.86932877
147Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86806156
148Hypotrichosis (HP:0001006)1.86751180
149Supernumerary spleens (HP:0009799)1.86045603
150Abnormality of the umbilical cord (HP:0010881)1.85647407
151Abnormal tarsal ossification (HP:0008369)1.84235611
152Renal Fanconi syndrome (HP:0001994)1.84129090
153Hyperglycinuria (HP:0003108)1.83745417
154Hypoplasia of the pons (HP:0012110)1.81336188
155Microvesicular hepatic steatosis (HP:0001414)1.80975054
156Absent forearm bone (HP:0003953)1.80913427
157Aplasia involving forearm bones (HP:0009822)1.80913427
158Tetraparesis (HP:0002273)1.80729866
159Abnormal hemoglobin (HP:0011902)1.80182617
160Thrombocytosis (HP:0001894)1.79882173
161Palmar hyperkeratosis (HP:0010765)1.79341051
162Horseshoe kidney (HP:0000085)1.78746642
163Patchy hypopigmentation of hair (HP:0011365)1.76899327
164Right ventricular cardiomyopathy (HP:0011663)1.76439079
165Hypoplasia of the odontoid process (HP:0003311)1.76135718
166Basal ganglia calcification (HP:0002135)1.75235918
167Abnormalities of placenta or umbilical cord (HP:0001194)1.74569156
168Gangrene (HP:0100758)1.73889707
169Vertebral compression fractures (HP:0002953)1.73164680
170Abnormality of the common coagulation pathway (HP:0010990)1.73157842
171Obstructive lung disease (HP:0006536)1.72654710
172Chronic obstructive pulmonary disease (HP:0006510)1.72654710
173Osteolytic defects of the hand bones (HP:0009699)1.72456130
174Osteolytic defects of the phalanges of the hand (HP:0009771)1.72456130
175Proximal placement of thumb (HP:0009623)1.71107650
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.70294631
177Sparse eyelashes (HP:0000653)1.69572597
178Nephroblastoma (Wilms tumor) (HP:0002667)1.69464608
179Generalized aminoaciduria (HP:0002909)1.66911163
180Exercise intolerance (HP:0003546)1.66300149
181Aplasia/Hypoplasia of the tibia (HP:0005772)1.66104212
182Retinal dysplasia (HP:0007973)1.65460239
183Embryonal renal neoplasm (HP:0011794)1.63511931
184Overlapping toe (HP:0001845)1.61385387
185Abnormality of monocarboxylic acid metabolism (HP:0010996)1.61195531
186Irregular epiphyses (HP:0010582)1.61063083
187Lethargy (HP:0001254)1.59322031
188Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.58808160
189Absent epiphyses (HP:0010577)1.58808160
190Atrophy/Degeneration involving motor neurons (HP:0007373)1.58469060
191Preaxial hand polydactyly (HP:0001177)1.55899632
192Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.55726593
193Decreased activity of mitochondrial respiratory chain (HP:0008972)1.55726593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.50754198
2BUB14.47706533
3NEK13.51463635
4ERN13.49056826
5WEE13.18260401
6IRAK33.08094978
7CDC73.06765985
8NME22.94551461
9MAP3K142.83164060
10TTK2.66442899
11SRPK12.57651599
12PBK2.55628388
13TRIM282.54538865
14EIF2AK12.51942119
15IRAK42.51185466
16EIF2AK32.49762201
17PIM22.48539733
18PLK42.46619157
19VRK22.39767366
20TBK12.39181971
21MST42.27412555
22MAP2K22.13452875
23PLK32.09833185
24MST1R2.03504956
25MAP3K31.95845239
26MAPKAPK31.88404210
27BLK1.87629914
28STK161.83042877
29BRSK21.81241258
30ZAK1.78486797
31IKBKE1.74339373
32TSSK61.74062495
33PLK11.71952060
34FRK1.69510417
35MAP4K21.67423444
36BRSK11.65985517
37MKNK11.61173944
38TYK21.54940054
39RIPK41.52877358
40VRK11.50753710
41CCNB11.49287972
42IKBKB1.45439163
43IRAK21.44906417
44PIK3CG1.44327485
45MKNK21.39731266
46ZAP701.35262258
47IRAK11.33374800
48TGFBR21.31141659
49NEK21.30023697
50NEK91.29595926
51MAP3K121.27794676
52PLK21.26050127
53LIMK11.24964204
54AURKB1.22339145
55MAP3K21.18942731
56TRPM71.17267071
57CSNK1G31.15188504
58NUAK11.13333995
59KIT1.12055365
60WNK31.10978340
61EPHB11.10886448
62JAK31.10455934
63CHEK21.08589252
64BMPR1B1.07996094
65TAOK31.07207519
66MAPK151.06515151
67ATR1.05573195
68INSRR1.03869191
69TXK1.02248756
70CSNK1A1L1.01528219
71CSNK1G11.00959644
72CSNK1G20.99940037
73TEC0.95562747
74SCYL20.95527706
75CSK0.93961335
76MAP4K10.92709723
77CDK70.92567098
78ERBB30.90837193
79EPHB20.90782306
80ERBB40.89216448
81ARAF0.86601330
82BMPR20.85855597
83MINK10.85368839
84RPS6KB20.84872617
85TESK10.84462917
86AURKA0.84133210
87ADRBK20.83054475
88PAK40.82224396
89PNCK0.81631520
90LRRK20.81579981
91CASK0.81496416
92SIK30.80112157
93CHUK0.79612042
94DYRK20.79171922
95CDK80.78978828
96JAK10.78365115
97MET0.78364203
98TESK20.76126629
99EPHA20.74727740
100EPHA30.74481384
101BCR0.74068247
102BTK0.73108842
103MAP3K130.71879542
104BRAF0.71861612
105GRK70.71573186
106PIK3CA0.71056997
107FER0.70545152
108MAPKAPK50.70495304
109STK390.70273410
110RIPK10.69652703
111CDK180.69017522
112CDK140.67751763
113CHEK10.65145004
114STK38L0.64783812
115LYN0.64557913
116CSF1R0.63806586
117DYRK30.63418328
118TNIK0.63329263
119MAP2K10.63078428
120FLT30.62827497
121ABL10.62499106
122ATM0.62491427
123CDK150.59892798
124MATK0.59550890
125EIF2AK20.59338718
126DYRK1B0.58657087
127CSNK2A10.57748324
128STK30.57362666
129CDK11A0.56208439
130GRK10.55958864
131SYK0.55937119
132MAP3K80.55616300
133MAP2K60.54827281
134CAMKK20.53677113
135ABL20.53348636
136TAF10.53133536
137PRKG20.52926153
138MAPKAPK20.52252981
139LCK0.50857413
140MAP2K70.50473640
141PRKCD0.50442903
142KDR0.50192032
143YES10.50180071
144CSNK2A20.49743125
145PTK60.49395645
146FGFR10.48804419
147EPHA40.48469927
148SIK10.48313481
149LATS10.47977895
150RPS6KA40.47414884
151NLK0.46755429
152PDK20.44056194
153FGR0.43500175
154JAK20.43016728
155NEK60.41770508
156CDK10.41596178
157PRKCI0.41544280
158HCK0.41507136
159PAK20.40645012
160PIM10.40235850
161TLK10.39685617
162DAPK10.39517812
163PRKCE0.39412514
164STK100.38892542
165IGF1R0.38433382
166MAP2K30.38270309
167FGFR30.37694545
168LATS20.35827202
169TGFBR10.35559386
170STK40.35237993
171RPS6KA50.34158758
172PRKCG0.33527677
173MOS0.32750130
174ITK0.32568594
175ACVR1B0.32460153
176NME10.32416046
177CDK20.31378179
178MAP3K40.31055236
179CSNK1E0.30363631

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049724.88567026
2Protein export_Homo sapiens_hsa030604.04076224
3DNA replication_Homo sapiens_hsa030303.28980101
4Fat digestion and absorption_Homo sapiens_hsa049753.27458856
5Protein digestion and absorption_Homo sapiens_hsa049743.26910818
6Mismatch repair_Homo sapiens_hsa034303.12987290
7Proteasome_Homo sapiens_hsa030503.09437642
8Other glycan degradation_Homo sapiens_hsa005112.28591203
9Steroid biosynthesis_Homo sapiens_hsa001002.26932768
10Base excision repair_Homo sapiens_hsa034102.21199469
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19931359
12Graft-versus-host disease_Homo sapiens_hsa053322.13353221
13Homologous recombination_Homo sapiens_hsa034402.13218488
14Non-homologous end-joining_Homo sapiens_hsa034502.07005359
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99382930
16Legionellosis_Homo sapiens_hsa051341.96444167
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93734485
18Fanconi anemia pathway_Homo sapiens_hsa034601.89772949
19Leishmaniasis_Homo sapiens_hsa051401.82088443
20Lysosome_Homo sapiens_hsa041421.81713369
21Nucleotide excision repair_Homo sapiens_hsa034201.81346954
22Pyruvate metabolism_Homo sapiens_hsa006201.76879719
23Sulfur metabolism_Homo sapiens_hsa009201.76865113
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75743786
25Staphylococcus aureus infection_Homo sapiens_hsa051501.75741180
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75565738
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74294974
28Biosynthesis of amino acids_Homo sapiens_hsa012301.70885188
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70139900
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.70123665
31Cell cycle_Homo sapiens_hsa041101.70119072
32One carbon pool by folate_Homo sapiens_hsa006701.70062325
33Parkinsons disease_Homo sapiens_hsa050121.62171830
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62014461
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58861255
36Pertussis_Homo sapiens_hsa051331.57363346
37RNA polymerase_Homo sapiens_hsa030201.54784165
38Allograft rejection_Homo sapiens_hsa053301.52629793
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51851376
40Pyrimidine metabolism_Homo sapiens_hsa002401.50819083
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.49973028
42Spliceosome_Homo sapiens_hsa030401.49701381
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49424779
44Carbon metabolism_Homo sapiens_hsa012001.49397539
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.49350355
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.48509371
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48458168
48Vitamin B6 metabolism_Homo sapiens_hsa007501.46746440
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46582560
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.45455356
51Glycerolipid metabolism_Homo sapiens_hsa005611.44498066
52RNA transport_Homo sapiens_hsa030131.43286552
53Vitamin digestion and absorption_Homo sapiens_hsa049771.41297273
54Rheumatoid arthritis_Homo sapiens_hsa053231.40271666
55Malaria_Homo sapiens_hsa051441.39980084
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39649100
57Arachidonic acid metabolism_Homo sapiens_hsa005901.37129149
58Sphingolipid metabolism_Homo sapiens_hsa006001.36534429
59Influenza A_Homo sapiens_hsa051641.35021634
60Linoleic acid metabolism_Homo sapiens_hsa005911.29438621
61Renin-angiotensin system_Homo sapiens_hsa046141.28818032
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28169316
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28135598
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26008087
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.25313314
66Huntingtons disease_Homo sapiens_hsa050161.23772106
67Intestinal immune network for IgA production_Homo sapiens_hsa046721.23015751
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20255468
69Type I diabetes mellitus_Homo sapiens_hsa049401.18338894
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17897140
71NF-kappa B signaling pathway_Homo sapiens_hsa040641.17386806
72NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17202356
73Basal transcription factors_Homo sapiens_hsa030221.16347583
74Sulfur relay system_Homo sapiens_hsa041221.15612918
75Drug metabolism - other enzymes_Homo sapiens_hsa009831.14121042
76SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09827123
77Tuberculosis_Homo sapiens_hsa051521.09353374
78Asthma_Homo sapiens_hsa053101.04965409
79RNA degradation_Homo sapiens_hsa030181.04412836
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04064226
81Osteoclast differentiation_Homo sapiens_hsa043801.00684234
82Phagosome_Homo sapiens_hsa041450.99409837
83Butanoate metabolism_Homo sapiens_hsa006500.98747593
84N-Glycan biosynthesis_Homo sapiens_hsa005100.96127963
85Measles_Homo sapiens_hsa051620.96098340
86Retinol metabolism_Homo sapiens_hsa008300.93174383
87Alzheimers disease_Homo sapiens_hsa050100.92967485
88Ether lipid metabolism_Homo sapiens_hsa005650.92459490
89Fatty acid metabolism_Homo sapiens_hsa012120.91844812
90Histidine metabolism_Homo sapiens_hsa003400.91631703
91Ribosome_Homo sapiens_hsa030100.90383647
92Glutathione metabolism_Homo sapiens_hsa004800.89858126
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88789862
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88446655
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87030404
96Caffeine metabolism_Homo sapiens_hsa002320.86912651
97Purine metabolism_Homo sapiens_hsa002300.84481411
98TNF signaling pathway_Homo sapiens_hsa046680.84428054
99Autoimmune thyroid disease_Homo sapiens_hsa053200.84404980
100p53 signaling pathway_Homo sapiens_hsa041150.84287665
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82050326
102Vibrio cholerae infection_Homo sapiens_hsa051100.82001795
103Arginine biosynthesis_Homo sapiens_hsa002200.81323805
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.80850181
105Propanoate metabolism_Homo sapiens_hsa006400.80611841
106Oocyte meiosis_Homo sapiens_hsa041140.78331282
107Tyrosine metabolism_Homo sapiens_hsa003500.78256022
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78232768
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78179497
110Toxoplasmosis_Homo sapiens_hsa051450.77532875
111Arginine and proline metabolism_Homo sapiens_hsa003300.76156066
112Pentose phosphate pathway_Homo sapiens_hsa000300.75368810
113Salmonella infection_Homo sapiens_hsa051320.74618546
114Chemical carcinogenesis_Homo sapiens_hsa052040.72282184
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71855723
116African trypanosomiasis_Homo sapiens_hsa051430.71269557
117Hematopoietic cell lineage_Homo sapiens_hsa046400.71154266
118Fatty acid elongation_Homo sapiens_hsa000620.71141194
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69027786
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69021664
121Phenylalanine metabolism_Homo sapiens_hsa003600.66488439
122Mineral absorption_Homo sapiens_hsa049780.65904250
123Hepatitis C_Homo sapiens_hsa051600.65550272
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64369324
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63268649
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61085338
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60834191
128Antigen processing and presentation_Homo sapiens_hsa046120.59572802
129* Folate biosynthesis_Homo sapiens_hsa007900.58222898
130Selenocompound metabolism_Homo sapiens_hsa004500.57350624
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56371250
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56314692
133Tryptophan metabolism_Homo sapiens_hsa003800.56050879
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.54691300
135Starch and sucrose metabolism_Homo sapiens_hsa005000.54170599
136Apoptosis_Homo sapiens_hsa042100.53069345
137mRNA surveillance pathway_Homo sapiens_hsa030150.53048455
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51118804
139Herpes simplex infection_Homo sapiens_hsa051680.50589607
140Peroxisome_Homo sapiens_hsa041460.47967621
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.45054664
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44261846
143Basal cell carcinoma_Homo sapiens_hsa052170.43977419
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43224653
145Galactose metabolism_Homo sapiens_hsa000520.42523907
146Viral myocarditis_Homo sapiens_hsa054160.41343947
147Hippo signaling pathway_Homo sapiens_hsa043900.39900409
148Complement and coagulation cascades_Homo sapiens_hsa046100.39462493
149beta-Alanine metabolism_Homo sapiens_hsa004100.39440320
150Fructose and mannose metabolism_Homo sapiens_hsa000510.39201685
151Shigellosis_Homo sapiens_hsa051310.38737138
152Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38362922
153Fatty acid degradation_Homo sapiens_hsa000710.36054600
154Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35004695
155Hedgehog signaling pathway_Homo sapiens_hsa043400.34662815
156TGF-beta signaling pathway_Homo sapiens_hsa043500.34485296
157Amoebiasis_Homo sapiens_hsa051460.32415813
158Lysine degradation_Homo sapiens_hsa003100.32379716
159B cell receptor signaling pathway_Homo sapiens_hsa046620.31145961
160Oxidative phosphorylation_Homo sapiens_hsa001900.29952466
161Hepatitis B_Homo sapiens_hsa051610.29527449
162Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28738747
163Metabolic pathways_Homo sapiens_hsa011000.28628643
164Alcoholism_Homo sapiens_hsa050340.27050295
165Primary immunodeficiency_Homo sapiens_hsa053400.26820708
166Cardiac muscle contraction_Homo sapiens_hsa042600.23537429
167Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22575009

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