GGNBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.88119141
2axonemal dynein complex assembly (GO:0070286)9.80009347
3multicellular organism reproduction (GO:0032504)9.56418787
4spermatid development (GO:0007286)9.49519513
5motile cilium assembly (GO:0044458)9.47035942
6piRNA metabolic process (GO:0034587)9.33984179
7plasma membrane fusion (GO:0045026)9.15601623
8epithelial cilium movement (GO:0003351)9.04224775
9male meiosis (GO:0007140)8.47057039
10synaptonemal complex organization (GO:0070193)8.25196026
11reproduction (GO:0000003)8.01311325
12synaptonemal complex assembly (GO:0007130)7.94049696
13regulation of cilium movement (GO:0003352)7.73405607
14cilium movement (GO:0003341)7.53508599
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.32322779
16organic cation transport (GO:0015695)6.68347639
17single fertilization (GO:0007338)6.66587160
18negative regulation of inclusion body assembly (GO:0090084)6.63981471
19sperm capacitation (GO:0048240)6.63777581
20response to pheromone (GO:0019236)6.62630722
21* spermatogenesis (GO:0007283)6.39140953
22* male gamete generation (GO:0048232)6.36699413
23DNA methylation involved in gamete generation (GO:0043046)6.25781610
24male meiosis I (GO:0007141)6.03711708
25fertilization (GO:0009566)6.02082480
26* gamete generation (GO:0007276)5.83827847
27regulation of inclusion body assembly (GO:0090083)5.52580228
28seminiferous tubule development (GO:0072520)5.50867689
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.48163453
30germ cell development (GO:0007281)5.47572539
31chromosome organization involved in meiosis (GO:0070192)5.45989459
32meiotic nuclear division (GO:0007126)5.01225840
33microtubule depolymerization (GO:0007019)4.92745990
34ventricular system development (GO:0021591)4.88068999
35calcium ion-dependent exocytosis (GO:0017156)4.82835373
36meiosis I (GO:0007127)4.82236585
37cell recognition (GO:0008037)4.63459155
38* multicellular organismal reproductive process (GO:0048609)4.56402075
39DNA packaging (GO:0006323)4.49868135
40left/right pattern formation (GO:0060972)4.48444935
41chromosome condensation (GO:0030261)4.46651263
42microtubule severing (GO:0051013)4.41968196
43regulation of microtubule-based movement (GO:0060632)4.37524337
44amino-acid betaine transport (GO:0015838)4.27253501
45carnitine transport (GO:0015879)4.27253501
46centriole replication (GO:0007099)4.24347104
47establishment of protein localization to Golgi (GO:0072600)4.21507419
48carnitine transmembrane transport (GO:1902603)4.21069361
49meiotic cell cycle (GO:0051321)4.06913197
50protein localization to cilium (GO:0061512)4.04698642
51cellular ketone body metabolic process (GO:0046950)4.00498056
52ketone body metabolic process (GO:1902224)4.00360960
53protein targeting to Golgi (GO:0000042)3.98437794
54genitalia morphogenesis (GO:0035112)3.96326747
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.80511581
56glycerol ether metabolic process (GO:0006662)3.75107043
57sequestering of actin monomers (GO:0042989)3.73457054
58tachykinin receptor signaling pathway (GO:0007217)3.72233685
59protein polyglutamylation (GO:0018095)3.67859048
60* multicellular organismal development (GO:0007275)3.66960857
61chaperone-mediated protein complex assembly (GO:0051131)3.62258974
62indolalkylamine metabolic process (GO:0006586)3.55598844
63retrograde transport, vesicle recycling within Golgi (GO:0000301)3.54389959
64spermatid nucleus differentiation (GO:0007289)3.52923529
65DNA double-strand break processing (GO:0000729)3.52545507
66regulation of spindle checkpoint (GO:0090231)3.51060931
67ether metabolic process (GO:0018904)3.44410195
68rRNA methylation (GO:0031167)3.41809175
69photoreceptor cell maintenance (GO:0045494)3.36108472
70axoneme assembly (GO:0035082)3.34257298
71synapsis (GO:0007129)3.30146466
72intraciliary transport (GO:0042073)3.25882128
73indole-containing compound catabolic process (GO:0042436)3.24866801
74indolalkylamine catabolic process (GO:0046218)3.24866801
75tryptophan catabolic process (GO:0006569)3.24866801
76neural tube formation (GO:0001841)3.24226252
77protein localization to Golgi apparatus (GO:0034067)3.22547479
78meiotic cell cycle process (GO:1903046)3.22188087
79monoubiquitinated protein deubiquitination (GO:0035520)3.21427037
80detection of light stimulus involved in visual perception (GO:0050908)3.19854969
81detection of light stimulus involved in sensory perception (GO:0050962)3.19854969
82lactate metabolic process (GO:0006089)3.14370830
83gene silencing by RNA (GO:0031047)3.13988321
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.13948276
85tryptophan metabolic process (GO:0006568)3.11882129
86single strand break repair (GO:0000012)3.11846248
87interferon-gamma secretion (GO:0072643)3.11827536
88quaternary ammonium group transport (GO:0015697)3.11491997
89RNA localization (GO:0006403)3.08016976
90peptidyl-glutamic acid modification (GO:0018200)3.07745384
91rRNA modification (GO:0000154)3.04584352
92DNA integration (GO:0015074)3.04398336
93negative regulation of organelle assembly (GO:1902116)3.02378978
94fucose catabolic process (GO:0019317)3.01524597
95L-fucose metabolic process (GO:0042354)3.01524597
96L-fucose catabolic process (GO:0042355)3.01524597
97histone mRNA catabolic process (GO:0071044)3.00523461
98RNA destabilization (GO:0050779)2.97061154
99amine catabolic process (GO:0009310)2.95290941
100cellular biogenic amine catabolic process (GO:0042402)2.95290941
101phosphatidylethanolamine biosynthetic process (GO:0006646)2.93373508
102kynurenine metabolic process (GO:0070189)2.89989048
103phosphatidylethanolamine metabolic process (GO:0046337)2.89918668
104protein refolding (GO:0042026)2.88497143
105microtubule polymerization or depolymerization (GO:0031109)2.88130557
106cilium organization (GO:0044782)2.86859683
107alditol metabolic process (GO:0019400)2.83235213
108centriole assembly (GO:0098534)2.83096790
109polyol catabolic process (GO:0046174)2.81992411
110double-strand break repair via homologous recombination (GO:0000724)2.80547720
111recombinational repair (GO:0000725)2.80439702
112positive regulation of macrophage activation (GO:0043032)2.79886891
113replication fork processing (GO:0031297)2.77578094
114nucleus organization (GO:0006997)2.77371705
115mannosylation (GO:0097502)2.76403591
116cellular component assembly involved in morphogenesis (GO:0010927)2.76030601
117regulation of meiosis I (GO:0060631)2.75064314
118fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.75016111
119regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.73004131
120retinal cone cell development (GO:0046549)2.72316094
121glycolytic process (GO:0006096)2.71021800
122regulation of protein glycosylation (GO:0060049)2.70549244
123cilium assembly (GO:0042384)2.69171139
124cornea development in camera-type eye (GO:0061303)2.68144341
125nucleosome disassembly (GO:0006337)2.66744142
126protein-DNA complex disassembly (GO:0032986)2.66744142
127cilium morphogenesis (GO:0060271)2.66521663
128auditory receptor cell stereocilium organization (GO:0060088)2.66094834
129mitotic sister chromatid cohesion (GO:0007064)2.65544541
130microtubule-based movement (GO:0007018)2.64370985
131reciprocal meiotic recombination (GO:0007131)2.64046414
132reciprocal DNA recombination (GO:0035825)2.64046414
133protein K11-linked deubiquitination (GO:0035871)2.63992581
134platelet dense granule organization (GO:0060155)2.62261233
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61222407
136negative regulation of skeletal muscle tissue development (GO:0048642)2.60008315
137sexual reproduction (GO:0019953)2.58435207
138nonmotile primary cilium assembly (GO:0035058)2.58196483
139adaptation of signaling pathway (GO:0023058)2.55466202
140phasic smooth muscle contraction (GO:0014821)2.54998443
141gene silencing (GO:0016458)2.52480592
142microtubule anchoring (GO:0034453)2.50167389
143histone H2A acetylation (GO:0043968)2.47791128
144regulation of cilium assembly (GO:1902017)2.47352657
145estrogen biosynthetic process (GO:0006703)2.45543350
146regulation of memory T cell differentiation (GO:0043380)2.40344767
147detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.40046975
148C4-dicarboxylate transport (GO:0015740)2.39893318
149preassembly of GPI anchor in ER membrane (GO:0016254)2.39203197
150sperm motility (GO:0030317)12.4516217
151fusion of sperm to egg plasma membrane (GO:0007342)12.0850624
152acrosome reaction (GO:0007340)11.4417210
153cell wall macromolecule metabolic process (GO:0044036)11.2314029
154cell wall macromolecule catabolic process (GO:0016998)11.2314029
155sperm-egg recognition (GO:0035036)11.0258442
156acrosome assembly (GO:0001675)10.9841775
157cilium or flagellum-dependent cell motility (GO:0001539)10.4481183
158binding of sperm to zona pellucida (GO:0007339)10.2638240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.99249054
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.86861904
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.93772961
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.89148786
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76956567
6IGF1R_20145208_ChIP-Seq_DFB_Human2.68014896
7GBX2_23144817_ChIP-Seq_PC3_Human2.59550328
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52552480
9FUS_26573619_Chip-Seq_HEK293_Human2.44732463
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.44728886
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41439761
12P300_19829295_ChIP-Seq_ESCs_Human2.27273828
13ER_23166858_ChIP-Seq_MCF-7_Human2.24238071
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19824310
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.14516575
16TAF15_26573619_Chip-Seq_HEK293_Human2.10790831
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.06796437
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.05528773
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05025021
20ZNF274_21170338_ChIP-Seq_K562_Hela2.04058897
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03165781
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02354315
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2689047
24VDR_22108803_ChIP-Seq_LS180_Human1.95179388
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.90849204
26EWS_26573619_Chip-Seq_HEK293_Human1.89167850
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.85688076
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81478816
29AR_25329375_ChIP-Seq_VCAP_Human1.73488402
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70346241
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69136523
32SMAD4_21799915_ChIP-Seq_A2780_Human1.68082679
33FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66410869
34STAT3_23295773_ChIP-Seq_U87_Human1.62152867
35STAT1_17558387_ChIP-Seq_HELA_Human1.61529964
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60303710
37BCAT_22108803_ChIP-Seq_LS180_Human1.54967563
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53985822
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52561010
40GATA3_21867929_ChIP-Seq_CD8_Mouse1.50597422
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.50575203
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.50167716
43KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.48556635
44TCF4_23295773_ChIP-Seq_U87_Human1.48227146
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.47037734
46* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.46308493
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45940935
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.45253895
49SOX2_19829295_ChIP-Seq_ESCs_Human1.44528099
50NANOG_19829295_ChIP-Seq_ESCs_Human1.44528099
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43728513
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.42635841
53TCF4_22108803_ChIP-Seq_LS180_Human1.42233858
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41360417
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40049993
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39884452
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38712417
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37857151
59MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37492127
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37449212
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37162747
62RUNX2_22187159_ChIP-Seq_PCA_Human1.36527136
63* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36161108
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.35829784
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34495300
66CBP_20019798_ChIP-Seq_JUKART_Human1.34435174
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34435174
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33705994
69GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.32410879
70CDX2_22108803_ChIP-Seq_LS180_Human1.31685741
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29833742
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.29511272
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28261471
74SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.27906251
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27805074
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.27450422
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.26832341
78P53_21459846_ChIP-Seq_SAOS-2_Human1.26390400
79AR_21572438_ChIP-Seq_LNCaP_Human1.26263005
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26061053
81ELK1_19687146_ChIP-ChIP_HELA_Human1.24549420
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23611446
83TP53_22573176_ChIP-Seq_HFKS_Human1.23462529
84LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23083312
85KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21574474
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.20695186
87* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20586510
88RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20080040
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20017662
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.20017662
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20012028
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.19735531
93KDM2B_26808549_Chip-Seq_REH_Human1.18954704
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18820914
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17442285
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17126176
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16087093
98IRF1_19129219_ChIP-ChIP_H3396_Human1.15575511
99P300_18555785_Chip-Seq_ESCs_Mouse1.15219845
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14868655
101EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14713744
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14314361
103REST_21632747_ChIP-Seq_MESCs_Mouse1.13909323
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13805322
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12844299
106SALL4_22934838_ChIP-ChIP_CD34+_Human1.12413095
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12054539
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.12027659
109TET1_21451524_ChIP-Seq_MESCs_Mouse1.11756043
110RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11080631
111ERG_20517297_ChIP-Seq_VCAP_Human1.10968225
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10842184
113MYC_27129775_Chip-Seq_CORNEA_Mouse1.10821585
114RARA_24833708_ChIP-Seq_LIVER_Mouse1.10390825
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09840513
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09840513
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09807017
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.09688795
119AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08643879
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07526486
121ETV1_20927104_ChIP-Seq_GIST48_Human1.07449965
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06709583
123GATA3_21878914_ChIP-Seq_MCF-7_Human1.06703633
124SPI1_26923725_Chip-Seq_HPCs_Mouse1.06557271
125CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06327040
126ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06306654
127MYC_18940864_ChIP-ChIP_HL60_Human1.06226655
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.06211476
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05383754
130* GF1_26923725_Chip-Seq_HPCs_Mouse1.04802968
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.04766609
132EST1_17652178_ChIP-ChIP_JURKAT_Human1.04203606
133* ESET_19884257_ChIP-Seq_ESCs_Mouse1.03463387
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.03459768
135HOXB7_26014856_ChIP-Seq_BT474_Human1.03411670
136GATA3_21867929_ChIP-Seq_TH1_Mouse1.02873694
137PHF8_20622853_ChIP-Seq_HELA_Human1.02603522
138CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02278387
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01456935
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01177248
141ELF1_20517297_ChIP-Seq_JURKAT_Human1.00338935
142* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98937206
143SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97277565
144LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97086405
145CTCF_20526341_ChIP-Seq_ESCs_Human0.96067663
146OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95869091
147OCT4_18555785_Chip-Seq_ESCs_Mouse0.94857230
148GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94734546
149SOX11_22085726_ChIP-Seq_ESNs_Mouse0.94596567
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.92956776
151CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92654851
152RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92590620
153* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91390097
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.90848293
155PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90190097
156P53_22387025_ChIP-Seq_ESCs_Mouse0.90051911
157SOX2_21211035_ChIP-Seq_LN229_Human0.88388701
158CBX2_27304074_Chip-Seq_ESCs_Mouse0.87738388
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87504939
160EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87103749
161PHF8_20622854_ChIP-Seq_HELA_Human0.86307966
162MYC_19829295_ChIP-Seq_ESCs_Human0.86177228
163LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85906816
164ESRRB_18555785_Chip-Seq_ESCs_Mouse0.85359139
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.85277141
166CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84624702
167KLF4_18555785_Chip-Seq_ESCs_Mouse0.84401444
168PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83857322
169BCOR_27268052_Chip-Seq_Bcells_Human0.83384287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.72931187
2MP0001929_abnormal_gametogenesis5.29337526
3MP0008877_abnormal_DNA_methylation4.35426473
4MP0002210_abnormal_sex_determination3.45129368
5MP0000372_irregular_coat_pigmentation3.34259176
6MP0003646_muscle_fatigue3.23209575
7MP0002161_abnormal_fertility/fecundity3.04165762
8MP0002102_abnormal_ear_morphology3.01291303
9MP0001145_abnormal_male_reproductive2.91914003
10MP0005670_abnormal_white_adipose2.86944651
11MP0000653_abnormal_sex_gland2.52362623
12MP0002160_abnormal_reproductive_system2.34221147
13MP0003136_yellow_coat_color2.33717122
14MP0005171_absent_coat_pigmentation2.29458937
15MP0001968_abnormal_touch/_nociception2.19251433
16MP0003718_maternal_effect2.18844637
17MP0005410_abnormal_fertilization15.2007151
18MP0002653_abnormal_ependyma_morphology1.98711136
19MP0001501_abnormal_sleep_pattern1.85485666
20MP0000569_abnormal_digit_pigmentation1.80076250
21MP0006072_abnormal_retinal_apoptosis1.74108436
22MP0002736_abnormal_nociception_after1.72999015
23MP0002938_white_spotting1.72920953
24MP0004233_abnormal_muscle_weight1.62702116
25MP0002138_abnormal_hepatobiliary_system1.60221707
26MP0001486_abnormal_startle_reflex1.59862429
27MP0008789_abnormal_olfactory_epithelium1.59000461
28MP0000015_abnormal_ear_pigmentation1.58317564
29MP0001986_abnormal_taste_sensitivity1.56918339
30MP0003880_abnormal_central_pattern1.51105727
31MP0004147_increased_porphyrin_level1.50305665
32MP0000427_abnormal_hair_cycle1.49197951
33MP0005645_abnormal_hypothalamus_physiol1.48281729
34MP0005365_abnormal_bile_salt1.39855493
35MP0003787_abnormal_imprinting1.37230061
36MP0001529_abnormal_vocalization1.36472018
37MP0002139_abnormal_hepatobiliary_system1.35480246
38MP0005075_abnormal_melanosome_morpholog1.34407819
39MP0005395_other_phenotype1.33493221
40MP0006292_abnormal_olfactory_placode1.30319639
41MP0001485_abnormal_pinna_reflex1.24741473
42MP0002095_abnormal_skin_pigmentation1.24388569
43MP0005647_abnormal_sex_gland1.23810973
44MP0006276_abnormal_autonomic_nervous1.22520275
45MP0008872_abnormal_physiological_respon1.22367099
46MP0010386_abnormal_urinary_bladder1.21212128
47MP0000383_abnormal_hair_follicle1.20022781
48MP0005174_abnormal_tail_pigmentation1.16536847
49MP0003011_delayed_dark_adaptation1.15111405
50MP0005389_reproductive_system_phenotype1.14583550
51MP0005367_renal/urinary_system_phenotyp1.09942872
52MP0000516_abnormal_urinary_system1.09942872
53MP0002254_reproductive_system_inflammat1.09749266
54MP0004036_abnormal_muscle_relaxation1.08436168
55MP0000751_myopathy1.05208751
56MP0000631_abnormal_neuroendocrine_gland1.04610987
57MP0009745_abnormal_behavioral_response1.03433657
58MP0006036_abnormal_mitochondrial_physio1.03372020
59MP0002837_dystrophic_cardiac_calcinosis1.03360392
60MP0005360_urolithiasis1.02778306
61MP0003878_abnormal_ear_physiology1.00260171
62MP0005377_hearing/vestibular/ear_phenot1.00260171
63MP0001765_abnormal_ion_homeostasis0.97368192
64MP0002735_abnormal_chemical_nociception0.96963242
65MP0001984_abnormal_olfaction0.96688101
66MP0005085_abnormal_gallbladder_physiolo0.96274176
67MP0000647_abnormal_sebaceous_gland0.95980175
68MP0003137_abnormal_impulse_conducting0.94669335
69MP0002168_other_aberrant_phenotype0.94321704
70MP0000749_muscle_degeneration0.90740584
71MP0002272_abnormal_nervous_system0.90573554
72MP0004885_abnormal_endolymph0.90255137
73MP0005394_taste/olfaction_phenotype0.88231012
74MP0005499_abnormal_olfactory_system0.88231012
75MP0002638_abnormal_pupillary_reflex0.86468796
76MP0008058_abnormal_DNA_repair0.86199136
77MP0004742_abnormal_vestibular_system0.84292307
78MP0002751_abnormal_autonomic_nervous0.83429293
79MP0005666_abnormal_adipose_tissue0.83090731
80MP0005379_endocrine/exocrine_gland_phen0.82727731
81MP0005084_abnormal_gallbladder_morpholo0.81790205
82MP0002282_abnormal_trachea_morphology0.80470401
83MP0002269_muscular_atrophy0.80292828
84MP0002876_abnormal_thyroid_physiology0.80088068
85MP0008875_abnormal_xenobiotic_pharmacok0.80035007
86MP0002557_abnormal_social/conspecific_i0.79953281
87MP0008995_early_reproductive_senescence0.79765782
88MP0006054_spinal_hemorrhage0.79440121
89MP0008057_abnormal_DNA_replication0.78619319
90MP0005623_abnormal_meninges_morphology0.76687102
91MP0000371_diluted_coat_color0.75513626
92MP0001970_abnormal_pain_threshold0.75352500
93MP0001963_abnormal_hearing_physiology0.74851782
94MP0003252_abnormal_bile_duct0.74772365
95MP0004924_abnormal_behavior0.72317416
96MP0005386_behavior/neurological_phenoty0.72317416
97MP0004019_abnormal_vitamin_homeostasis0.71894267
98MP0002067_abnormal_sensory_capabilities0.71433554
99MP0001764_abnormal_homeostasis0.70875560
100MP0004084_abnormal_cardiac_muscle0.68527780
101MP0009764_decreased_sensitivity_to0.67922988
102MP0005167_abnormal_blood-brain_barrier0.67005093
103MP0002234_abnormal_pharynx_morphology0.62717862
104MP0003950_abnormal_plasma_membrane0.62219950
105MP0003115_abnormal_respiratory_system0.61062527
106MP0005636_abnormal_mineral_homeostasis0.59893475
107MP0004043_abnormal_pH_regulation0.58832921
108MP0009278_abnormal_bone_marrow0.56216792
109MP0010329_abnormal_lipoprotein_level0.55781724
110MP0002928_abnormal_bile_duct0.54942127
111MP0001324_abnormal_eye_pigmentation0.54890529
112MP0001661_extended_life_span0.53613312
113MP0004130_abnormal_muscle_cell0.52801419
114MP0010094_abnormal_chromosome_stability0.52601367
115MP0006035_abnormal_mitochondrial_morpho0.52380717
116MP0003699_abnormal_female_reproductive0.52048990
117MP0002106_abnormal_muscle_physiology0.49395867
118MP0005319_abnormal_enzyme/_coenzyme0.48333023
119MP0004087_abnormal_muscle_fiber0.46830627
120MP0002118_abnormal_lipid_homeostasis0.46803470
121MP0000358_abnormal_cell_content/0.46734743
122MP0009046_muscle_twitch0.45872246
123MP0002971_abnormal_brown_adipose0.45872110
124MP0005397_hematopoietic_system_phenotyp0.44988975
125MP0001545_abnormal_hematopoietic_system0.44988975
126MP0001293_anophthalmia0.44820731
127MP0003195_calcinosis0.44430011
128MP0009697_abnormal_copulation0.43670638
129MP0003786_premature_aging0.40477406
130MP0010630_abnormal_cardiac_muscle0.39532376
131MP0005332_abnormal_amino_acid0.38307048
132MP0005083_abnormal_biliary_tract0.37181810
133MP0002108_abnormal_muscle_morphology0.36727778
134MP0005369_muscle_phenotype0.35541960
135MP0009115_abnormal_fat_cell0.34896868
136MP0003879_abnormal_hair_cell0.33333860
137MP0005620_abnormal_muscle_contractility0.32863102
138MP0001119_abnormal_female_reproductive0.30842912
139MP0008007_abnormal_cellular_replicative0.30827592
140MP0004215_abnormal_myocardial_fiber0.30805813
141MP0005253_abnormal_eye_physiology0.30527353
142MP0000609_abnormal_liver_physiology0.30358391
143MP0003806_abnormal_nucleotide_metabolis0.30274453
144MP0008961_abnormal_basal_metabolism0.30076628
145MP0006138_congestive_heart_failure0.29152669
146MP0005646_abnormal_pituitary_gland0.28775988
147MP0000759_abnormal_skeletal_muscle0.28651828
148MP0003045_fibrosis0.28513728
149MP0003959_abnormal_lean_body0.28259667
150MP0005375_adipose_tissue_phenotype0.27967525
151MP0004133_heterotaxia0.27359016
152MP0004134_abnormal_chest_morphology0.27275053
153MP0002127_abnormal_cardiovascular_syste0.27055210
154MP0005551_abnormal_eye_electrophysiolog0.25988432
155MP0004085_abnormal_heartbeat0.25830395
156MP0005584_abnormal_enzyme/coenzyme_acti0.25727419
157MP0005391_vision/eye_phenotype0.25206213
158MP0004145_abnormal_muscle_electrophysio0.24919319
159MP0005266_abnormal_metabolism0.23744543
160MP0003868_abnormal_feces_composition0.23670706
161MP0004808_abnormal_hematopoietic_stem0.22568900

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.80320624
2Abnormal respiratory epithelium morphology (HP:0012253)8.53105740
3Abnormal respiratory motile cilium morphology (HP:0005938)8.53105740
4Rhinitis (HP:0012384)7.64751507
5Chronic bronchitis (HP:0004469)6.97631304
6Abnormal ciliary motility (HP:0012262)6.72688847
7Infertility (HP:0000789)6.55345115
8Nasal polyposis (HP:0100582)6.11738846
9Abnormality of the nasal mucosa (HP:0000433)5.05394636
10Nephronophthisis (HP:0000090)4.85419549
11Bronchiectasis (HP:0002110)4.38439013
12Pancreatic cysts (HP:0001737)4.18568121
13Bronchitis (HP:0012387)4.13847985
14Chronic hepatic failure (HP:0100626)3.84221404
15Abnormality of the renal medulla (HP:0100957)3.70755676
16Pancreatic fibrosis (HP:0100732)3.65967495
17Male infertility (HP:0003251)3.64673506
18True hermaphroditism (HP:0010459)3.61886664
19Severe visual impairment (HP:0001141)3.47375706
20Attenuation of retinal blood vessels (HP:0007843)3.40908603
21Abnormal spermatogenesis (HP:0008669)3.33310809
22Recurrent otitis media (HP:0000403)3.15969129
23Tubulointerstitial nephritis (HP:0001970)3.05224913
24Abnormality of macular pigmentation (HP:0008002)3.00763241
25Gonadotropin excess (HP:0000837)2.94838498
26Tubular atrophy (HP:0000092)2.94160814
27Recurrent sinusitis (HP:0011108)2.92253275
28Type II lissencephaly (HP:0007260)2.90125689
29Congenital stationary night blindness (HP:0007642)2.89773091
30Intestinal atresia (HP:0011100)2.87535389
31Tubulointerstitial abnormality (HP:0001969)2.81769153
32Gaze-evoked nystagmus (HP:0000640)2.81465859
33Abnormality of the lower motor neuron (HP:0002366)2.76762873
34Abnormality of midbrain morphology (HP:0002418)2.71719212
35Molar tooth sign on MRI (HP:0002419)2.71719212
36Hypothermia (HP:0002045)2.65139647
37Azoospermia (HP:0000027)2.64591594
38Absent speech (HP:0001344)2.63431448
39Impulsivity (HP:0100710)2.55437355
40Amelogenesis imperfecta (HP:0000705)2.55319224
41Congenital primary aphakia (HP:0007707)2.54208987
42Abnormal drinking behavior (HP:0030082)2.51436623
43Polydipsia (HP:0001959)2.51436623
44Gait imbalance (HP:0002141)2.50836357
45Abnormal rod and cone electroretinograms (HP:0008323)2.50623932
46Medial flaring of the eyebrow (HP:0010747)2.49679923
47Retinal dysplasia (HP:0007973)2.43487854
48Tubulointerstitial fibrosis (HP:0005576)2.42280979
49Nephrogenic diabetes insipidus (HP:0009806)2.38654909
50Abnormal gallbladder physiology (HP:0012438)2.38613907
51Cholecystitis (HP:0001082)2.38613907
52Hyperventilation (HP:0002883)2.38434508
53Hypoproteinemia (HP:0003075)2.36141545
54Abnormality of the renal cortex (HP:0011035)2.34054496
55Genital tract atresia (HP:0001827)2.30969676
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.30425844
57Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30082200
58Stomach cancer (HP:0012126)2.25312355
59Recurrent bronchitis (HP:0002837)2.24659106
60Abolished electroretinogram (ERG) (HP:0000550)2.21015830
61Congenital hepatic fibrosis (HP:0002612)2.18209904
62Stage 5 chronic kidney disease (HP:0003774)2.17984377
63Impaired proprioception (HP:0010831)2.17933441
64Bony spicule pigmentary retinopathy (HP:0007737)2.17305400
65Exercise-induced myalgia (HP:0003738)2.17029125
66Postaxial foot polydactyly (HP:0001830)2.14428443
67Progressive cerebellar ataxia (HP:0002073)2.14335238
68Fibular hypoplasia (HP:0003038)2.12873038
69Type I transferrin isoform profile (HP:0003642)2.10267796
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.09771898
71Volvulus (HP:0002580)2.09516034
72Vaginal atresia (HP:0000148)2.07855525
73Abnormality of renal excretion (HP:0011036)2.05452723
74Renal cortical cysts (HP:0000803)2.03628513
75Renal dysplasia (HP:0000110)2.00243272
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5347046
77Dynein arm defect of respiratory motile cilia (HP:0012255)12.2722627
78Absent/shortened dynein arms (HP:0200106)12.2722627
79Aplasia/Hypoplasia of the tibia (HP:0005772)1.98055264
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94477189
81Abnormal protein N-linked glycosylation (HP:0012347)1.94477189
82Abnormal protein glycosylation (HP:0012346)1.94477189
83Abnormal glycosylation (HP:0012345)1.94477189
84Sclerocornea (HP:0000647)1.94423979
85Febrile seizures (HP:0002373)1.94070073
86Bifid tongue (HP:0010297)1.92488345
87Albinism (HP:0001022)1.92080209
88Pendular nystagmus (HP:0012043)1.92057352
89Abnormality of dental color (HP:0011073)1.91517523
90Amyotrophic lateral sclerosis (HP:0007354)1.90732295
91Occipital encephalocele (HP:0002085)1.90672261
92Sloping forehead (HP:0000340)1.89754295
93Genetic anticipation (HP:0003743)1.89140228
94Bile duct proliferation (HP:0001408)1.88670594
95Abnormal biliary tract physiology (HP:0012439)1.88670594
96Astigmatism (HP:0000483)1.88042306
97Myoglobinuria (HP:0002913)1.87638233
98Anencephaly (HP:0002323)1.86823499
99Lissencephaly (HP:0001339)1.86355826
100Increased corneal curvature (HP:0100692)1.86095597
101Keratoconus (HP:0000563)1.86095597
102Dyschromatopsia (HP:0007641)1.84971525
103Progressive inability to walk (HP:0002505)1.84561980
104Hypoplasia of the fovea (HP:0007750)1.83538730
105Aplasia/Hypoplasia of the fovea (HP:0008060)1.83538730
106Abnormal urine output (HP:0012590)1.81060426
107Inability to walk (HP:0002540)1.80617630
108Hypoalbuminemia (HP:0003073)1.78568040
109Abnormal albumin level (HP:0012116)1.78568040
110Absent epiphyses (HP:0010577)1.78190624
111Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78190624
112Photophobia (HP:0000613)1.77633212
113Retinitis pigmentosa (HP:0000510)1.77532685
114Atonic seizures (HP:0010819)1.77087236
115Prominent nasal bridge (HP:0000426)1.77014248
116Methylmalonic acidemia (HP:0002912)1.76789898
117Oculomotor apraxia (HP:0000657)1.76368880
118Preaxial hand polydactyly (HP:0001177)1.76050750
119Poor coordination (HP:0002370)1.75961962
120Spastic tetraparesis (HP:0001285)1.74575348
121Gastrointestinal atresia (HP:0002589)1.72042125
122Prostate neoplasm (HP:0100787)1.71295089
123Focal motor seizures (HP:0011153)1.70263666
124Upper motor neuron abnormality (HP:0002127)1.69990847
125Abnormality of the fovea (HP:0000493)1.69899689
126Widely spaced teeth (HP:0000687)1.68243766
127Decreased central vision (HP:0007663)1.68225283
128Abnormality of the ileum (HP:0001549)1.67517193
129Fair hair (HP:0002286)1.67321517
130Bell-shaped thorax (HP:0001591)1.67308314
131Polyuria (HP:0000103)1.66343482
132Asymmetric septal hypertrophy (HP:0001670)1.62306727
133Short ribs (HP:0000773)1.61017848
134Rhabdomyolysis (HP:0003201)1.57956918
135Choroideremia (HP:0001139)1.57910853
136Postaxial hand polydactyly (HP:0001162)1.55201858
137Heterotopia (HP:0002282)1.52421031
138Double outlet right ventricle (HP:0001719)1.51088517
139Congenital malformation of the right heart (HP:0011723)1.51088517
140Abnormality of the dental root (HP:0006486)1.51031705
141Taurodontia (HP:0000679)1.51031705
142Abnormality of permanent molar morphology (HP:0011071)1.51031705
143J-shaped sella turcica (HP:0002680)1.47823209
144Easy fatigability (HP:0003388)1.47732078
145Short femoral neck (HP:0100864)1.47534898
146Generalized muscle weakness (HP:0003324)1.46671374
147Hemorrhage of the eye (HP:0011885)1.46637644
148Short thorax (HP:0010306)1.46433990
149Nephropathy (HP:0000112)1.46369003
150Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.46063422
151Vascular calcification (HP:0004934)1.44944047
152Facial cleft (HP:0002006)1.44510538
153Bundle branch block (HP:0011710)1.44026556
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.43946344
155Difficulty climbing stairs (HP:0003551)1.43779736
156Abnormality of the dental pulp (HP:0006479)1.42728436
157Abnormality of molar (HP:0011077)1.39878198
158Abnormality of molar morphology (HP:0011070)1.39878198
159Hyporeflexia of lower limbs (HP:0002600)1.39133990
160Exercise-induced muscle cramps (HP:0003710)1.38949455
161Deformed sella turcica (HP:0002681)1.38672413
162EMG: neuropathic changes (HP:0003445)1.37502278
163Cystic liver disease (HP:0006706)1.35686485
164Abnormality of the neuromuscular junction (HP:0003398)1.33760071
165Fatigable weakness (HP:0003473)1.33760071
166Chronic sinusitis (HP:0011109)1.32004119
167Aplasia/Hypoplasia of the lens (HP:0008063)1.28807273
168Cerebellar dysplasia (HP:0007033)1.28479949
169Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.27663727
170Retinal atrophy (HP:0001105)1.27375596
171Hyperkalemia (HP:0002153)1.25810677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.97871227
2PDK47.97871227
3TESK16.43234405
4PDK25.15795034
5FRK4.90409345
6PRKD34.73882304
7ICK4.48098305
8MAP4K22.95685024
9TRIM282.77698388
10PTK2B2.50897606
11NUAK12.44166076
12WNK42.39132191
13PLK42.36972958
14EIF2AK32.24758840
15STK382.22032103
16CASK2.05652291
17NEK22.02767510
18STK392.00229773
19ACVR1B1.94935267
20PLK21.85390583
21MST41.74618971
22BRSK21.71193358
23PNCK1.65632859
24ERBB31.59429535
25MAPK131.54014967
26GRK11.49438771
27TAOK31.44605067
28OXSR11.43200563
29MKNK21.36351776
30MAPK151.30242503
31MAP3K41.28875492
32DYRK1B1.27941687
33PAK31.23982183
34BCR1.20733986
35PINK11.14656790
36TGFBR11.11841078
37PDK11.04790128
38WNK11.01876139
39TXK1.01755550
40FER1.00533035
41STK160.98859076
42PRKCE0.96295108
43BMPR20.94311264
44CAMKK20.91884006
45STK30.89531529
46VRK10.87905954
47DYRK30.81193743
48MUSK0.79432732
49AKT30.78337728
50PLK30.77201624
51EPHA40.76720595
52STK38L0.75821304
53IRAK10.75800640
54MKNK10.75762122
55SIK30.75203272
56CCNB10.74248222
57CDK80.71999684
58PASK0.69083867
59CSNK1G10.67361490
60MARK10.66891836
61TEC0.66887819
62CSNK1A1L0.65552476
63TTK0.64419317
64TYRO30.64145843
65PDPK10.59791994
66NTRK30.59217809
67CAMK1G0.56579437
68BUB10.55562437
69TAF10.55294417
70CSNK1G30.54024980
71TNK20.53645308
72OBSCN0.53622435
73BRSK10.53040060
74TNIK0.50432654
75IKBKB0.49757459
76RPS6KA40.49472113
77INSRR0.49318443
78ADRBK10.48669488
79CSNK1G20.47865992
80CHEK20.47115811
81MAP2K70.46600076
82IRAK20.44532205
83PRKAA10.44071502
84PBK0.44019932
85EEF2K0.43755722
86BRD40.42140818
87BCKDK0.42074698
88ATR0.41731180
89ABL10.41453536
90TLK10.40248757
91MAP2K60.37325201
92SRPK10.37257937
93CSNK1A10.36956147
94LMTK20.36322007
95NLK0.36284392
96FLT30.36199435
97MARK30.34638045
98MTOR0.34117521
99MAP2K10.33706899
100MARK20.33360290
101CLK10.32992931
102CHEK10.32621671
103ATM0.29115630
104NTRK20.28640608
105IGF1R0.28453077
106EPHA30.28385452
107TTN0.28234970
108CHUK0.27664174
109RIPK40.25610644
110PRKCG0.24590741
111SIK10.22329873
112CSF1R0.22213194
113RPS6KB10.21443913
114CDK120.21267158
115PAK20.20876259
116SIK20.18942860
117PHKG10.18563798
118PHKG20.18563798
119TESK20.18500018
120CDC70.18435785
121WNK30.16868209
122PRKCQ0.16218511
123PAK10.14812016
124LATS10.12677387
125PAK40.11604326
126MAP3K50.10860911
127PKN10.10687137
128PRKCZ0.09347235
129PRKAA20.09333766
130TRIB30.07826259
131RPS6KA10.07809328
132PRKACG0.07684729
133MAP3K100.06103124
134PIK3CG0.05948462
135YES10.05825453
136PRKG10.05756419
137PLK10.05310097
138MYLK0.05213715
139ZAK0.05161545
140EPHB10.04964724
141WEE10.04217581
142CSNK2A10.04163257
143ZAP700.04094920
144CSK0.04038312
145NEK60.03038890
146GSK3B0.02809304
147STK40.01426483
148PRKACB0.01333756
149CDK30.01068865
150PIM10.00930303
151CSNK1D0.00795715
152MAPK80.00613919
153CAMK10.00500388
154BRAF0.00415658
155BMPR1B0.00396197
156ERN1-0.0211013
157PRKCA-0.0186788
158CAMK2A-0.0180886
159STK11-0.0176645
160CDK2-0.0172612
161ADRBK2-0.0091778
162CDK4-0.0022989
163PRKACA-0.0015942

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.16204007
2Pyruvate metabolism_Homo sapiens_hsa006204.02354768
3Propanoate metabolism_Homo sapiens_hsa006404.00833383
4Vitamin B6 metabolism_Homo sapiens_hsa007503.95316425
5Fatty acid biosynthesis_Homo sapiens_hsa000613.77133526
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.72683098
7Selenocompound metabolism_Homo sapiens_hsa004502.82172902
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.78658377
9Protein export_Homo sapiens_hsa030602.72187901
10Non-homologous end-joining_Homo sapiens_hsa034502.65902654
11Linoleic acid metabolism_Homo sapiens_hsa005912.63330684
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58472849
13Glucagon signaling pathway_Homo sapiens_hsa049222.58125649
14Phototransduction_Homo sapiens_hsa047442.50556809
15Fatty acid degradation_Homo sapiens_hsa000712.40970829
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32165786
17PPAR signaling pathway_Homo sapiens_hsa033202.24702558
18Homologous recombination_Homo sapiens_hsa034402.20507684
19Fatty acid metabolism_Homo sapiens_hsa012122.07952779
20Glycerolipid metabolism_Homo sapiens_hsa005612.05744367
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83906002
22Olfactory transduction_Homo sapiens_hsa047401.82870600
23Basal transcription factors_Homo sapiens_hsa030221.81266119
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78146892
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76891961
26Carbon metabolism_Homo sapiens_hsa012001.75244176
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73864511
28Fanconi anemia pathway_Homo sapiens_hsa034601.72408559
29Pentose phosphate pathway_Homo sapiens_hsa000301.67676190
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67483481
31Fat digestion and absorption_Homo sapiens_hsa049751.66917102
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.65648602
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.62058547
34Cardiac muscle contraction_Homo sapiens_hsa042601.60583776
35Proteasome_Homo sapiens_hsa030501.55415535
36Dorso-ventral axis formation_Homo sapiens_hsa043201.52664839
37Fructose and mannose metabolism_Homo sapiens_hsa000511.52013180
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.48987362
39Steroid biosynthesis_Homo sapiens_hsa001001.47841267
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46992272
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46783501
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45193731
43Regulation of autophagy_Homo sapiens_hsa041401.40824866
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36958965
45Caffeine metabolism_Homo sapiens_hsa002321.34932491
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.34131749
47RNA degradation_Homo sapiens_hsa030181.32766428
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30401167
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30076106
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21492301
51Huntingtons disease_Homo sapiens_hsa050161.19932278
52RNA polymerase_Homo sapiens_hsa030201.19510670
53ABC transporters_Homo sapiens_hsa020101.18390150
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16328487
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.13895140
56Chemical carcinogenesis_Homo sapiens_hsa052041.13087285
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07802007
58Amphetamine addiction_Homo sapiens_hsa050311.05447625
59Biosynthesis of amino acids_Homo sapiens_hsa012301.02474368
60Nicotine addiction_Homo sapiens_hsa050331.02466500
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01848086
62Glutathione metabolism_Homo sapiens_hsa004801.00615722
63SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00217571
64Circadian rhythm_Homo sapiens_hsa047100.99204558
65Peroxisome_Homo sapiens_hsa041460.97079635
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94956374
67Sphingolipid metabolism_Homo sapiens_hsa006000.94334495
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.93367272
69Collecting duct acid secretion_Homo sapiens_hsa049660.93311217
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93240274
71Ether lipid metabolism_Homo sapiens_hsa005650.91369671
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.89300892
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89232872
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.86465300
75Oocyte meiosis_Homo sapiens_hsa041140.83813756
76Renin secretion_Homo sapiens_hsa049240.78003741
77Bile secretion_Homo sapiens_hsa049760.75740715
78Systemic lupus erythematosus_Homo sapiens_hsa053220.73398856
79One carbon pool by folate_Homo sapiens_hsa006700.73050126
80Arachidonic acid metabolism_Homo sapiens_hsa005900.71516374
81Tryptophan metabolism_Homo sapiens_hsa003800.71313463
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69625719
83Purine metabolism_Homo sapiens_hsa002300.67243441
84Morphine addiction_Homo sapiens_hsa050320.67200265
85mRNA surveillance pathway_Homo sapiens_hsa030150.67097581
86Mineral absorption_Homo sapiens_hsa049780.67000389
87Graft-versus-host disease_Homo sapiens_hsa053320.64779183
88Asthma_Homo sapiens_hsa053100.63629599
89Type I diabetes mellitus_Homo sapiens_hsa049400.63225890
90Complement and coagulation cascades_Homo sapiens_hsa046100.63153326
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61531676
92Retinol metabolism_Homo sapiens_hsa008300.61516927
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61315202
94AMPK signaling pathway_Homo sapiens_hsa041520.58274091
95Antigen processing and presentation_Homo sapiens_hsa046120.57802558
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55700444
97Metabolic pathways_Homo sapiens_hsa011000.55367379
98Pyrimidine metabolism_Homo sapiens_hsa002400.54841662
99Serotonergic synapse_Homo sapiens_hsa047260.52540901
100Lysine degradation_Homo sapiens_hsa003100.52241757
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51774281
102Oxidative phosphorylation_Homo sapiens_hsa001900.50685563
103Allograft rejection_Homo sapiens_hsa053300.49604849
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.49449712
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48938190
106N-Glycan biosynthesis_Homo sapiens_hsa005100.48893556
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.47737273
108TGF-beta signaling pathway_Homo sapiens_hsa043500.47189431
109Calcium signaling pathway_Homo sapiens_hsa040200.46795560
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45971596
111Circadian entrainment_Homo sapiens_hsa047130.45625183
112Autoimmune thyroid disease_Homo sapiens_hsa053200.44993920
113Insulin resistance_Homo sapiens_hsa049310.43705511
114Primary immunodeficiency_Homo sapiens_hsa053400.43604519
115p53 signaling pathway_Homo sapiens_hsa041150.42960262
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.41823598
117RNA transport_Homo sapiens_hsa030130.40600464
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40006302
119Arginine biosynthesis_Homo sapiens_hsa002200.39480599
120Salivary secretion_Homo sapiens_hsa049700.38957708
121Starch and sucrose metabolism_Homo sapiens_hsa005000.38618764
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38087962
123Hedgehog signaling pathway_Homo sapiens_hsa043400.37735983
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37217669
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37098831
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36098299
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35937472
128Insulin secretion_Homo sapiens_hsa049110.33528970
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32493185
130beta-Alanine metabolism_Homo sapiens_hsa004100.32090522
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31054395
132Fatty acid elongation_Homo sapiens_hsa000620.30813379
133Phenylalanine metabolism_Homo sapiens_hsa003600.28800040
134Vitamin digestion and absorption_Homo sapiens_hsa049770.28653901
135Estrogen signaling pathway_Homo sapiens_hsa049150.27572514
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27489191
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27150537
138Butanoate metabolism_Homo sapiens_hsa006500.24551697
139Legionellosis_Homo sapiens_hsa051340.24380096
140Sulfur metabolism_Homo sapiens_hsa009200.24123118
141Sulfur relay system_Homo sapiens_hsa041220.22622314
142Nitrogen metabolism_Homo sapiens_hsa009100.20510290
143Long-term potentiation_Homo sapiens_hsa047200.19656353
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.19143971
145Pancreatic secretion_Homo sapiens_hsa049720.18627626
146Arginine and proline metabolism_Homo sapiens_hsa003300.18233478
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17257562
148Histidine metabolism_Homo sapiens_hsa003400.16682964
149Taste transduction_Homo sapiens_hsa047420.14571797
150Alcoholism_Homo sapiens_hsa050340.14383783
151B cell receptor signaling pathway_Homo sapiens_hsa046620.14332885
152Alzheimers disease_Homo sapiens_hsa050100.13709047

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