GGNBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.75132338
2fusion of sperm to egg plasma membrane (GO:0007342)9.48429026
3sperm motility (GO:0030317)8.73802898
4epithelial cilium movement (GO:0003351)7.91383255
5acrosome assembly (GO:0001675)7.86502540
6piRNA metabolic process (GO:0034587)7.66686709
7cell wall macromolecule metabolic process (GO:0044036)7.43636470
8cell wall macromolecule catabolic process (GO:0016998)7.43636470
9multicellular organism reproduction (GO:0032504)7.38309476
10plasma membrane fusion (GO:0045026)7.25413851
11axonemal dynein complex assembly (GO:0070286)7.03462295
12sperm-egg recognition (GO:0035036)6.97675229
13cilium movement (GO:0003341)6.91345999
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.36181430
15cell-cell recognition (GO:0009988)6.28486478
16spermatid development (GO:0007286)6.01922917
17reproduction (GO:0000003)5.98711327
18male meiosis (GO:0007140)5.98416882
19binding of sperm to zona pellucida (GO:0007339)5.96942276
20acrosome reaction (GO:0007340)5.91430771
21synaptonemal complex organization (GO:0070193)5.74479912
22regulation of cilium movement (GO:0003352)5.74371069
23motile cilium assembly (GO:0044458)5.57407145
24single fertilization (GO:0007338)5.04763052
25synaptonemal complex assembly (GO:0007130)4.99088320
26centriole replication (GO:0007099)4.90735760
27DNA methylation involved in gamete generation (GO:0043046)4.89628064
28histone H3-K4 trimethylation (GO:0080182)4.82285671
29regulation of DNA endoreduplication (GO:0032875)4.72069945
30male meiosis I (GO:0007141)4.56528857
31ventricular system development (GO:0021591)4.50064903
32synapsis (GO:0007129)4.43080285
33response to pheromone (GO:0019236)4.18771360
34microtubule nucleation (GO:0007020)4.12446930
35sperm capacitation (GO:0048240)4.11943761
36spermatid nucleus differentiation (GO:0007289)4.10467056
37negative regulation of inclusion body assembly (GO:0090084)4.09283420
38fertilization (GO:0009566)4.00435387
39genitalia morphogenesis (GO:0035112)3.97247895
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95617786
41negative regulation of cell killing (GO:0031342)3.95617786
42glycerol ether metabolic process (GO:0006662)3.85186694
43meiotic nuclear division (GO:0007126)3.83860513
44meiotic chromosome segregation (GO:0045132)3.77156487
45centriole assembly (GO:0098534)3.72180616
46regulation of meiosis I (GO:0060631)3.64311887
47seminiferous tubule development (GO:0072520)3.63864665
48ether metabolic process (GO:0018904)3.56292170
49pyrimidine dimer repair (GO:0006290)3.54144478
50tachykinin receptor signaling pathway (GO:0007217)3.52493329
51protein targeting to Golgi (GO:0000042)3.51332345
52peptidyl-lysine trimethylation (GO:0018023)3.48582987
53chromosome organization involved in meiosis (GO:0070192)3.46672039
54intra-Golgi vesicle-mediated transport (GO:0006891)3.46374452
55* spermatogenesis (GO:0007283)3.44346621
56* male gamete generation (GO:0048232)3.43194102
57microtubule anchoring (GO:0034453)3.41705795
58protein localization to cilium (GO:0061512)3.39889882
59antigen processing and presentation via MHC class Ib (GO:0002475)3.39706876
60establishment of protein localization to Golgi (GO:0072600)3.37806466
61cellular process involved in reproduction in multicellular organism (GO:0022412)3.31715862
62germ cell development (GO:0007281)3.31439349
63single strand break repair (GO:0000012)3.30296185
64cell recognition (GO:0008037)3.25773245
65mitotic sister chromatid cohesion (GO:0007064)3.24966641
66regulation of protein glycosylation (GO:0060049)3.24574304
67calcium ion-dependent exocytosis (GO:0017156)3.23882097
68Golgi to endosome transport (GO:0006895)3.19205709
69meiosis I (GO:0007127)3.16512159
70leukocyte aggregation (GO:0070486)3.12472324
71retrograde transport, vesicle recycling within Golgi (GO:0000301)3.12185273
72organic cation transport (GO:0015695)3.10094320
73* gamete generation (GO:0007276)3.06090177
74axoneme assembly (GO:0035082)3.04005849
75histone H3-K9 demethylation (GO:0033169)3.02355213
76intraciliary transport (GO:0042073)3.02350391
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01336177
78negative regulation of DNA-dependent DNA replication (GO:2000104)3.00363023
79meiotic cell cycle (GO:0051321)3.00145628
80positive regulation of growth hormone secretion (GO:0060124)2.99742298
81monoubiquitinated protein deubiquitination (GO:0035520)2.99441525
82regulation of microtubule-based movement (GO:0060632)2.99187344
83protein K63-linked deubiquitination (GO:0070536)2.98073531
84GTP biosynthetic process (GO:0006183)2.96120712
85resolution of meiotic recombination intermediates (GO:0000712)2.95487380
86neural tube formation (GO:0001841)2.89686850
87histone H3-K4 methylation (GO:0051568)2.87485322
88interkinetic nuclear migration (GO:0022027)2.85809789
89negative regulation of neurotransmitter secretion (GO:0046929)2.84111396
90reciprocal DNA recombination (GO:0035825)2.82778459
91reciprocal meiotic recombination (GO:0007131)2.82778459
92histone mRNA catabolic process (GO:0071044)2.78420271
93vesicle transport along microtubule (GO:0047496)2.76871060
94negative regulation of T cell mediated immunity (GO:0002710)2.76451136
95signal peptide processing (GO:0006465)2.75633009
96response to methylmercury (GO:0051597)2.74347743
97rRNA catabolic process (GO:0016075)2.73770538
98negative regulation of meiosis (GO:0045835)2.73696434
99protein deubiquitination (GO:0016579)2.73256761
100meiotic cell cycle process (GO:1903046)2.66978688
101protein K6-linked ubiquitination (GO:0085020)2.66610985
102activated T cell proliferation (GO:0050798)2.65109423
103negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.64987292
104gene silencing by RNA (GO:0031047)2.63728488
105regulation of telomere maintenance (GO:0032204)2.61097465
106RNA destabilization (GO:0050779)2.59425716
107triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.59320143
108phenol-containing compound catabolic process (GO:0019336)2.59043037
109protein modification by small protein removal (GO:0070646)2.58192422
110negative regulation of neurotransmitter transport (GO:0051589)2.55493822
111sequestering of metal ion (GO:0051238)2.55423672
112female gamete generation (GO:0007292)2.54784530
113DNA methylation (GO:0006306)2.54730505
114DNA alkylation (GO:0006305)2.54730505
115cilium morphogenesis (GO:0060271)2.52978848
116nucleoside diphosphate phosphorylation (GO:0006165)2.52303594
117protein K48-linked ubiquitination (GO:0070936)2.50780344
118positive regulation of granulocyte differentiation (GO:0030854)2.50367084
119protein refolding (GO:0042026)2.49775019
120interferon-gamma production (GO:0032609)2.48951458
121regulation of inclusion body assembly (GO:0090083)2.47334335
122negative regulation of glycoprotein biosynthetic process (GO:0010561)2.46771896
123* multicellular organismal reproductive process (GO:0048609)2.46688668
124protein K48-linked deubiquitination (GO:0071108)2.45662844
125regulation of memory T cell differentiation (GO:0043380)2.45543740
126protein localization to Golgi apparatus (GO:0034067)2.45293442
127COPII vesicle coating (GO:0048208)2.44910090
128regulation of protein polyubiquitination (GO:1902914)2.44686079
129peptidyl-lysine methylation (GO:0018022)2.44618919
130behavioral response to nicotine (GO:0035095)2.44212504
131hypotonic response (GO:0006971)2.43744872
132peptidyl-glutamic acid modification (GO:0018200)2.40856399
133left/right pattern formation (GO:0060972)2.40211450
134regulation of germinal center formation (GO:0002634)2.39798633
135positive regulation of meiosis (GO:0045836)2.38772173
136regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.38455884
137protein polyglutamylation (GO:0018095)2.37713853
138negative regulation of mast cell activation (GO:0033004)2.37487666
139anterograde synaptic vesicle transport (GO:0048490)2.37450557
140mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.35736376
141positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.35736376
142negative regulation of type 2 immune response (GO:0002829)2.35735258
143interleukin-6-mediated signaling pathway (GO:0070102)2.35493812
144regulation of hexokinase activity (GO:1903299)2.35134969
145regulation of glucokinase activity (GO:0033131)2.35134969
146protein K11-linked deubiquitination (GO:0035871)2.35072818
147positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.34510916
148regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.34510916
149ether lipid metabolic process (GO:0046485)2.33655081
150sister chromatid cohesion (GO:0007062)2.32912507
151very-low-density lipoprotein particle assembly (GO:0034379)2.32874981
152attachment of spindle microtubules to kinetochore (GO:0008608)2.32838075
153histone H3-K9 methylation (GO:0051567)2.32653207
154UTP biosynthetic process (GO:0006228)2.32542195
155regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.31827986
156positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.31827986
157regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.31259538
158retinal cone cell development (GO:0046549)2.30394071
159regulation of T cell tolerance induction (GO:0002664)2.29172833
160lactate metabolic process (GO:0006089)2.28131410
161early endosome to late endosome transport (GO:0045022)2.28020519
162negative regulation of lymphocyte mediated immunity (GO:0002707)2.26560504
163hydrogen peroxide biosynthetic process (GO:0050665)2.25892193
164UTP metabolic process (GO:0046051)2.24883961
165cell redox homeostasis (GO:0045454)2.24728900
166erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.24436702
167L-phenylalanine catabolic process (GO:0006559)2.24436702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.83103191
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01516633
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99490976
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.95884733
5IGF1R_20145208_ChIP-Seq_DFB_Human2.90565155
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.79978009
7EZH2_22144423_ChIP-Seq_EOC_Human2.73795143
8TAF15_26573619_Chip-Seq_HEK293_Human2.70794010
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.55583666
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46178325
11FUS_26573619_Chip-Seq_HEK293_Human2.46173600
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36449434
13GBX2_23144817_ChIP-Seq_PC3_Human2.18302989
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18286936
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13736610
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11802951
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01692950
18EWS_26573619_Chip-Seq_HEK293_Human2.00723214
19* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.95533222
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.91586112
21TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.85123139
22ZNF274_21170338_ChIP-Seq_K562_Hela1.82375811
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78723058
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77962698
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.77555344
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.77043380
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75447171
28CBP_20019798_ChIP-Seq_JUKART_Human1.75283413
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.75283413
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74250865
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74024074
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73473893
33* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72132968
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.71680827
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70793988
36P53_22387025_ChIP-Seq_ESCs_Mouse1.68126106
37EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.67440923
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66115930
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64623221
40IRF1_19129219_ChIP-ChIP_H3396_Human1.64345856
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62054425
42GATA1_22025678_ChIP-Seq_K562_Human1.59166884
43* STAT3_23295773_ChIP-Seq_U87_Human1.58517619
44SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58130337
45* VDR_23849224_ChIP-Seq_CD4+_Human1.58093059
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.57892130
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.57645491
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55074283
49P300_18555785_Chip-Seq_ESCs_Mouse1.54233845
50KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.53988858
51ELK1_19687146_ChIP-ChIP_HELA_Human1.52220903
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.52203399
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.51796069
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.50331386
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49550177
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.48096559
57OCT4_18555785_Chip-Seq_ESCs_Mouse1.48065048
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.46539304
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46465984
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.44815517
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44690142
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.43561919
63P300_19829295_ChIP-Seq_ESCs_Human1.43395582
64TP53_22573176_ChIP-Seq_HFKS_Human1.42654593
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.42322779
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40726840
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38402459
68SMAD4_21799915_ChIP-Seq_A2780_Human1.38248306
69STAT3_18555785_Chip-Seq_ESCs_Mouse1.38054441
70NMYC_18555785_Chip-Seq_ESCs_Mouse1.36902625
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.36454136
72ER_23166858_ChIP-Seq_MCF-7_Human1.36323827
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.36022984
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33811721
75* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33763411
76RUNX2_22187159_ChIP-Seq_PCA_Human1.33378911
77VDR_22108803_ChIP-Seq_LS180_Human1.31037347
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30029193
79ESRRB_18555785_Chip-Seq_ESCs_Mouse1.29506732
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28803012
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27651595
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26888956
83RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25847329
84BCAT_22108803_ChIP-Seq_LS180_Human1.25516960
85AR_21572438_ChIP-Seq_LNCaP_Human1.24703048
86PU1_27457419_Chip-Seq_LIVER_Mouse1.24005967
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.23071436
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.22838270
89KLF4_18555785_Chip-Seq_ESCs_Mouse1.22650511
90GATA3_26560356_Chip-Seq_TH2_Human1.22371168
91* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22147533
92OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21548158
93KDM2B_26808549_Chip-Seq_REH_Human1.21356351
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21240063
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20549730
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.20191354
97CTCF_18555785_Chip-Seq_ESCs_Mouse1.20171200
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19723081
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19347814
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19162286
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19162286
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18730679
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.18592918
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17665097
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17665097
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17658047
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17626472
108SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16514215
109* RXR_22158963_ChIP-Seq_LIVER_Mouse1.16409924
110CDX2_22108803_ChIP-Seq_LS180_Human1.13570543
111ZFX_18555785_Chip-Seq_ESCs_Mouse1.13457910
112PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12881165
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12584503
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.12053997
115GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.11699312
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11510528
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11441410
118SMRT_27268052_Chip-Seq_Bcells_Human1.11084437
119TCF4_23295773_ChIP-Seq_U87_Human1.10474588
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10305759
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09867545
122SALL4_22934838_ChIP-ChIP_CD34+_Human1.08522603
123CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07132651
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06688417
125FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05689558
126KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05608755
127AR_25329375_ChIP-Seq_VCAP_Human1.04729082
128* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04448130
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04101921
130NANOG_19829295_ChIP-Seq_ESCs_Human1.03912677
131SOX2_19829295_ChIP-Seq_ESCs_Human1.03912677
132SMAD4_21741376_ChIP-Seq_EPCs_Human1.03802324
133IRF8_27001747_Chip-Seq_BMDM_Mouse1.02955632
134TP63_19390658_ChIP-ChIP_HaCaT_Human1.02874821
135FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02529551
136FOXA1_25329375_ChIP-Seq_VCAP_Human1.02529551
137GATA3_26560356_Chip-Seq_TH1_Human1.01697882
138RUNX_20019798_ChIP-Seq_JUKART_Human1.01583363
139VDR_24787735_ChIP-Seq_THP-1_Human1.00004870
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99562473
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99499086
142PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99323145
143TCF4_22108803_ChIP-Seq_LS180_Human0.98407255
144RNF2_27304074_Chip-Seq_NSC_Mouse0.97260293
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96802676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.94445432
2MP0008877_abnormal_DNA_methylation4.34551449
3MP0002139_abnormal_hepatobiliary_system4.13534422
4MP0003698_abnormal_male_reproductive3.01002832
5MP0001929_abnormal_gametogenesis2.88573944
6MP0003724_increased_susceptibility_to2.75116888
7MP0005360_urolithiasis2.59446438
8MP0008058_abnormal_DNA_repair2.28218265
9MP0005075_abnormal_melanosome_morpholog2.21520434
10MP0002102_abnormal_ear_morphology2.18473449
11MP0005365_abnormal_bile_salt2.11550683
12MP0000015_abnormal_ear_pigmentation2.09575051
13MP0002009_preneoplasia2.01044573
14MP0008875_abnormal_xenobiotic_pharmacok1.99486048
15MP0003252_abnormal_bile_duct1.95540647
16MP0002095_abnormal_skin_pigmentation1.91324621
17MP0005085_abnormal_gallbladder_physiolo1.90017331
18MP0005671_abnormal_response_to1.89796059
19MP0002210_abnormal_sex_determination1.89139788
20MP0003718_maternal_effect1.85540509
21MP0001986_abnormal_taste_sensitivity1.83033087
22MP0002166_altered_tumor_susceptibility1.82208471
23MP0002735_abnormal_chemical_nociception1.81924245
24MP0003436_decreased_susceptibility_to1.77196924
25MP0003656_abnormal_erythrocyte_physiolo1.72893802
26MP0001188_hyperpigmentation1.71041399
27MP0009697_abnormal_copulation1.69950801
28MP0003121_genomic_imprinting1.67470278
29MP0006276_abnormal_autonomic_nervous1.66977288
30MP0002138_abnormal_hepatobiliary_system1.64320962
31MP0004142_abnormal_muscle_tone1.62126270
32MP0002234_abnormal_pharynx_morphology1.61860749
33MP0001145_abnormal_male_reproductive1.60976247
34MP0003787_abnormal_imprinting1.60348170
35MP0001529_abnormal_vocalization1.57625614
36MP0005551_abnormal_eye_electrophysiolog1.56322747
37MP0003183_abnormal_peptide_metabolism1.53259474
38MP0001968_abnormal_touch/_nociception1.50705432
39MP0002822_catalepsy1.48750155
40MP0008057_abnormal_DNA_replication1.48267190
41MP0008789_abnormal_olfactory_epithelium1.48207566
42MP0002928_abnormal_bile_duct1.45678127
43MP0005387_immune_system_phenotype1.42658016
44MP0001790_abnormal_immune_system1.42658016
45MP0000653_abnormal_sex_gland1.42452504
46MP0002161_abnormal_fertility/fecundity1.41467496
47MP0008961_abnormal_basal_metabolism1.37542031
48MP0002282_abnormal_trachea_morphology1.36902882
49MP0006292_abnormal_olfactory_placode1.34119256
50MP0005636_abnormal_mineral_homeostasis1.31413524
51MP0010234_abnormal_vibrissa_follicle1.29920998
52MP0001666_abnormal_nutrient_absorption1.27543220
53MP0000609_abnormal_liver_physiology1.26206057
54MP0003868_abnormal_feces_composition1.26083978
55MP0000685_abnormal_immune_system1.24582270
56MP0005000_abnormal_immune_tolerance1.23209468
57MP0001835_abnormal_antigen_presentation1.23184232
58MP0009785_altered_susceptibility_to1.22683006
59MP0002277_abnormal_respiratory_mucosa1.22425265
60MP0001502_abnormal_circadian_rhythm1.22369732
61MP0005386_behavior/neurological_phenoty1.20606673
62MP0004924_abnormal_behavior1.20606673
63MP0004742_abnormal_vestibular_system1.20137610
64MP0005535_abnormal_body_temperature1.18484255
65MP0009745_abnormal_behavioral_response1.18371517
66MP0005503_abnormal_tendon_morphology1.14962283
67MP0006054_spinal_hemorrhage1.14949532
68MP0000013_abnormal_adipose_tissue1.14691888
69MP0002736_abnormal_nociception_after1.13865479
70MP0000427_abnormal_hair_cycle1.13418691
71MP0000372_irregular_coat_pigmentation1.13390237
72MP0000569_abnormal_digit_pigmentation1.12947632
73MP0001533_abnormal_skeleton_physiology1.11521442
74MP0002971_abnormal_brown_adipose1.11454690
75MP0000604_amyloidosis1.11189510
76MP0002405_respiratory_system_inflammati1.10065402
77MP0003890_abnormal_embryonic-extraembry1.09940449
78MP0002272_abnormal_nervous_system1.08713774
79MP0001800_abnormal_humoral_immune1.07964425
80MP0010329_abnormal_lipoprotein_level1.06677982
81MP0001765_abnormal_ion_homeostasis1.06426192
82MP0005025_abnormal_response_to1.03080517
83MP0003763_abnormal_thymus_physiology1.02667593
84MP0002006_tumorigenesis1.01711645
85MP0001501_abnormal_sleep_pattern1.00358607
86MP0009379_abnormal_foot_pigmentation0.99518698
87MP0001845_abnormal_inflammatory_respons0.98412774
88MP0002723_abnormal_immune_serum0.97721916
89MP0002419_abnormal_innate_immunity0.97158574
90MP0001545_abnormal_hematopoietic_system0.96848089
91MP0005397_hematopoietic_system_phenotyp0.96848089
92MP0002420_abnormal_adaptive_immunity0.96623600
93MP0008995_early_reproductive_senescence0.96287306
94MP0003866_abnormal_defecation0.96081729
95MP0005394_taste/olfaction_phenotype0.94488372
96MP0005499_abnormal_olfactory_system0.94488372
97MP0003880_abnormal_central_pattern0.94146746
98MP0002067_abnormal_sensory_capabilities0.93815834
99MP0002398_abnormal_bone_marrow0.93629549
100MP0006082_CNS_inflammation0.93218958
101MP0001819_abnormal_immune_cell0.92984600
102MP0005253_abnormal_eye_physiology0.92929380
103MP0005379_endocrine/exocrine_gland_phen0.91584377
104MP0005319_abnormal_enzyme/_coenzyme0.91193144
105MP0001984_abnormal_olfaction0.91163741
106MP0005084_abnormal_gallbladder_morpholo0.90749337
107MP0009046_muscle_twitch0.90564872
108MP0001853_heart_inflammation0.90300669
109MP0005174_abnormal_tail_pigmentation0.90065667
110MP0002933_joint_inflammation0.89445135
111MP0002452_abnormal_antigen_presenting0.89087201
112MP0003300_gastrointestinal_ulcer0.88831070
113MP0005464_abnormal_platelet_physiology0.88569001
114MP0000465_gastrointestinal_hemorrhage0.88236524
115MP0009764_decreased_sensitivity_to0.87924129
116MP0002876_abnormal_thyroid_physiology0.87068038
117MP0002118_abnormal_lipid_homeostasis0.86861655
118MP0005389_reproductive_system_phenotype0.86007940
119MP0003786_premature_aging0.85775682
120MP0010155_abnormal_intestine_physiology0.84876830
121MP0008469_abnormal_protein_level0.84600131
122MP0009763_increased_sensitivity_to0.83849748
123MP0001119_abnormal_female_reproductive0.83372055
124MP0004264_abnormal_extraembryonic_tissu0.81848962
125MP0003122_maternal_imprinting0.81007164
126MP0009765_abnormal_xenobiotic_induced0.80070874
127MP0003646_muscle_fatigue0.79307277
128MP0005584_abnormal_enzyme/coenzyme_acti0.79126158
129MP0002163_abnormal_gland_morphology0.79026772
130MP0001486_abnormal_startle_reflex0.79014649
131MP0003195_calcinosis0.78903409
132MP0005310_abnormal_salivary_gland0.78428290
133MP0006035_abnormal_mitochondrial_morpho0.78190450
134MP0009115_abnormal_fat_cell0.76756833
135MP0001764_abnormal_homeostasis0.76662600
136MP0003329_amyloid_beta_deposits0.75831225
137MP0005083_abnormal_biliary_tract0.75501847
138MP0002693_abnormal_pancreas_physiology0.75467495
139MP0010094_abnormal_chromosome_stability0.75168492
140MP0003172_abnormal_lysosome_physiology0.74702379
141MP0002132_abnormal_respiratory_system0.74019922
142MP0005395_other_phenotype0.73482997
143MP0004130_abnormal_muscle_cell0.72790527
144MP0009780_abnormal_chondrocyte_physiolo0.72643683
145MP0004147_increased_porphyrin_level0.72365453
146MP0000703_abnormal_thymus_morphology0.71537801
147MP0001919_abnormal_reproductive_system0.70412428
148MP0002557_abnormal_social/conspecific_i0.69683935
149MP0006072_abnormal_retinal_apoptosis0.69338230
150MP0000689_abnormal_spleen_morphology0.69246335
151MP0000371_diluted_coat_color0.67666939
152MP0002396_abnormal_hematopoietic_system0.67343848
153MP0002572_abnormal_emotion/affect_behav0.66515568
154MP0003186_abnormal_redox_activity0.66314166
155MP0006036_abnormal_mitochondrial_physio0.65458888
156MP0003699_abnormal_female_reproductive0.63361677
157MP0005367_renal/urinary_system_phenotyp0.63151533
158MP0000516_abnormal_urinary_system0.63151533
159MP0001970_abnormal_pain_threshold0.60984948
160MP0004885_abnormal_endolymph0.60685922

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.01217340
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.01217340
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.10684069
4Abnormal respiratory motile cilium physiology (HP:0012261)6.56629581
5Abnormal respiratory motile cilium morphology (HP:0005938)6.32076775
6Abnormal respiratory epithelium morphology (HP:0012253)6.32076775
7Abnormal ciliary motility (HP:0012262)6.15982488
8Nasal polyposis (HP:0100582)5.34427465
9Rhinitis (HP:0012384)5.24205492
10Chronic bronchitis (HP:0004469)4.87605303
11Abnormality of the nasal mucosa (HP:0000433)4.25806941
12Infertility (HP:0000789)4.05649030
13Bronchitis (HP:0012387)4.00260759
14Bronchiectasis (HP:0002110)3.96776300
15Recurrent sinusitis (HP:0011108)3.87393631
16Chronic hepatic failure (HP:0100626)3.67667589
17Pancreatic cysts (HP:0001737)3.63652497
18Pancreatic fibrosis (HP:0100732)3.52633090
19Recurrent bronchitis (HP:0002837)3.42031063
20Acanthocytosis (HP:0001927)3.37429323
21Absent speech (HP:0001344)3.33871113
22Spontaneous abortion (HP:0005268)3.27121610
23Widely spaced teeth (HP:0000687)3.16334162
24Nephronophthisis (HP:0000090)3.14935515
25Papillary thyroid carcinoma (HP:0002895)2.88930646
26Abnormal spermatogenesis (HP:0008669)2.79992950
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.79303972
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.79303972
29Epidermoid cyst (HP:0200040)2.79180695
30True hermaphroditism (HP:0010459)2.79041404
31Recurrent otitis media (HP:0000403)2.69039891
32Gonadotropin excess (HP:0000837)2.65350905
33Oligodactyly (hands) (HP:0001180)2.64896701
34Azoospermia (HP:0000027)2.59289709
35Severe combined immunodeficiency (HP:0004430)2.56492418
36Abnormal rod and cone electroretinograms (HP:0008323)2.53549536
37Medial flaring of the eyebrow (HP:0010747)2.52558742
38Drooling (HP:0002307)2.50601636
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49423065
40Truncal obesity (HP:0001956)2.47094812
41Median cleft lip (HP:0000161)2.46882140
42Hypothermia (HP:0002045)2.46249845
43Poikilocytosis (HP:0004447)2.45550887
44Thyroid-stimulating hormone excess (HP:0002925)2.45019143
45Vascular calcification (HP:0004934)2.44330571
46Thyroiditis (HP:0100646)2.43836094
47Prolonged partial thromboplastin time (HP:0003645)2.42696795
48Tented upper lip vermilion (HP:0010804)2.40317643
49Abnormality of the renal medulla (HP:0100957)2.40304984
50Excessive salivation (HP:0003781)2.36516191
51Gaze-evoked nystagmus (HP:0000640)2.35658198
52Metaphyseal dysplasia (HP:0100255)2.34012663
53Fair hair (HP:0002286)2.32555888
54Severe visual impairment (HP:0001141)2.31775884
55Abnormality of the corticospinal tract (HP:0002492)2.28703961
56Conjugated hyperbilirubinemia (HP:0002908)2.25307141
57Cardiovascular calcification (HP:0011915)2.24141433
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.21512115
59Abnormality of the renal cortex (HP:0011035)2.19180551
60Fibular hypoplasia (HP:0003038)2.18848587
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18260035
62Progressive cerebellar ataxia (HP:0002073)2.17923946
63Amyotrophic lateral sclerosis (HP:0007354)2.17808035
64Intestinal atresia (HP:0011100)2.14286241
65Atonic seizures (HP:0010819)2.13374415
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.13199106
67Chronic sinusitis (HP:0011109)2.11899815
68Papilledema (HP:0001085)2.11566326
69Autoimmune hemolytic anemia (HP:0001890)2.09618478
70Cystic liver disease (HP:0006706)2.06991099
71Abnormality of the metopic suture (HP:0005556)2.05465087
72Prominent metopic ridge (HP:0005487)2.04973186
73Broad-based gait (HP:0002136)2.04194885
74Absent frontal sinuses (HP:0002688)2.03448281
75Submucous cleft hard palate (HP:0000176)2.00750048
76Combined immunodeficiency (HP:0005387)2.00040635
77Volvulus (HP:0002580)1.98195175
78Hypobetalipoproteinemia (HP:0003563)1.96144957
79Attenuation of retinal blood vessels (HP:0007843)1.96043841
80Narrow forehead (HP:0000341)1.95487460
81Epiphyseal dysplasia (HP:0002656)1.94117675
82Tubulointerstitial nephritis (HP:0001970)1.91256145
83Recurrent gram-negative bacterial infections (HP:0005420)1.90130829
84Abnormality of the heme biosynthetic pathway (HP:0010472)1.89203072
85Abnormality of the labia minora (HP:0012880)1.87777468
86Sloping forehead (HP:0000340)1.87168773
87Congenital hepatic fibrosis (HP:0002612)1.85664254
88Abnormality of DNA repair (HP:0003254)1.84921250
89Dyskinesia (HP:0100660)1.84573406
90Broad alveolar ridges (HP:0000187)1.83923194
91Xanthomatosis (HP:0000991)1.83275995
92Hypoplasia of the thymus (HP:0000778)1.83030623
93Astigmatism (HP:0000483)1.82790311
94Pustule (HP:0200039)1.82605171
95Abnormality of eosinophils (HP:0001879)1.82546936
96Abnormality of the common coagulation pathway (HP:0010990)1.81427190
97Increased IgM level (HP:0003496)1.80551251
98Generalized hypopigmentation of hair (HP:0011358)1.80487188
99Abnormality of midbrain morphology (HP:0002418)1.80103358
100Molar tooth sign on MRI (HP:0002419)1.80103358
101Tubular atrophy (HP:0000092)1.78039737
102Abnormality of macular pigmentation (HP:0008002)1.77782260
103Short tibia (HP:0005736)1.77411861
104Congenital stationary night blindness (HP:0007642)1.77170862
105T lymphocytopenia (HP:0005403)1.75904279
106Abnormal tarsal ossification (HP:0008369)1.74539732
107Abnormality of T cell number (HP:0011839)1.74023419
108Abnormal foot bone ossification (HP:0010675)1.73978294
109Increased mean platelet volume (HP:0011877)1.73730611
110Abolished electroretinogram (ERG) (HP:0000550)1.72412692
111Male pseudohermaphroditism (HP:0000037)1.72108717
112Abnormality of chromosome stability (HP:0003220)1.71826373
113Abnormality of B cell number (HP:0010975)1.71571754
114Hyperbilirubinemia (HP:0002904)1.71549853
115Lip pit (HP:0100267)1.71214520
116Albinism (HP:0001022)1.71176231
117Hypochromic anemia (HP:0001931)1.70677450
118Atrophy/Degeneration involving motor neurons (HP:0007373)1.69257273
119Bile duct proliferation (HP:0001408)1.68165660
120Abnormal biliary tract physiology (HP:0012439)1.68165660
121Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.68139808
122Abnormal platelet volume (HP:0011876)1.68113555
123Prominent nasal bridge (HP:0000426)1.68064991
124Osteomalacia (HP:0002749)1.67695237
125Type II lissencephaly (HP:0007260)1.67664523
126Hypochromic microcytic anemia (HP:0004840)1.66317904
127Neoplasm of the tracheobronchial system (HP:0100552)1.66302670
128Thyroid carcinoma (HP:0002890)1.65137319
129Renal cortical cysts (HP:0000803)1.64921617
130Elevated erythrocyte sedimentation rate (HP:0003565)1.64580799
131Postaxial foot polydactyly (HP:0001830)1.64541168
132B lymphocytopenia (HP:0010976)1.64072780
133Myocardial infarction (HP:0001658)1.63952460
134Abnormality of the renal collecting system (HP:0004742)1.63805049
135Hepatitis (HP:0012115)1.63680516
136Abnormality of glutamine family amino acid metabolism (HP:0010902)1.62788976
137Dyschromatopsia (HP:0007641)1.62176650
138Polyphagia (HP:0002591)1.61948534
139Hypolipoproteinemia (HP:0010981)1.61316910
140Hyperventilation (HP:0002883)1.61085607
141Progressive microcephaly (HP:0000253)1.60599387
142Methylmalonic acidemia (HP:0002912)1.60282505
143Abnormal drinking behavior (HP:0030082)1.60003962
144Polydipsia (HP:0001959)1.60003962
145Menstrual irregularities (HP:0000858)1.59945532
146Abnormality of salivation (HP:0100755)1.59871423
147Abnormality of proline metabolism (HP:0010907)1.59003655
148Hydroxyprolinuria (HP:0003080)1.59003655
149Menorrhagia (HP:0000132)1.58978337
150Hyperlipoproteinemia (HP:0010980)1.58974207
151Alveolar cell carcinoma (HP:0006519)1.57842551
152Febrile seizures (HP:0002373)1.57809568
153Neonatal respiratory distress (HP:0002643)1.57508482
154Abnormal hemoglobin (HP:0011902)1.57449715
155Cupped ear (HP:0000378)1.57241422
156Abnormality of T cell physiology (HP:0011840)1.56396738
157Nephrogenic diabetes insipidus (HP:0009806)1.56119715
158Abnormality of the right ventricle (HP:0001707)1.55402038
159Abnormality of T cells (HP:0002843)1.55304727
160Chronic diarrhea (HP:0002028)1.55056498
161Tubulointerstitial abnormality (HP:0001969)1.54849541
162Gait imbalance (HP:0002141)1.54359538
163Congenital primary aphakia (HP:0007707)1.54013287
164Acute hepatic failure (HP:0006554)1.53146957
165Hyperkalemia (HP:0002153)1.53040484
166Microcytic anemia (HP:0001935)1.51705815
167Irregular epiphyses (HP:0010582)1.51344995
168Intrahepatic cholestasis (HP:0001406)1.50907920
169Protuberant abdomen (HP:0001538)1.50758005
170Delayed gross motor development (HP:0002194)1.50429336
171Chronic mucocutaneous candidiasis (HP:0002728)1.49250270
172Recurrent cutaneous fungal infections (HP:0011370)1.49250270
173Hypoalphalipoproteinemia (HP:0003233)1.48480894
174Abnormality of lateral ventricle (HP:0030047)1.46432210
175Abnormal hair whorl (HP:0010721)1.46136711
17611 pairs of ribs (HP:0000878)1.44335396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.06092744
2PDK36.06092744
3PDK23.48461517
4TAOK33.38586625
5TESK13.11794501
6PNCK3.09854131
7RIPK43.08795576
8EIF2AK32.70555259
9BCKDK2.69023769
10WNK42.58881988
11MAP3K122.33992486
12PTK2B2.18866385
13MAPK132.18138733
14BRD42.10694784
15CASK2.04646094
16CDK192.02304133
17MAP4K21.98070326
18BMPR1B1.93793172
19FRK1.93420443
20GRK61.91745420
21AKT31.83841307
22PLK41.83685478
23TRIM281.79345366
24TEC1.72684313
25BCR1.67904241
26MAP3K141.65094553
27TXK1.59961261
28CAMK1G1.52167903
29WNK11.51011414
30MAPK151.48156736
31CDK121.33870092
32JAK31.32066851
33STK391.30941804
34MARK11.29492504
35MKNK21.29380102
36ERN11.27013614
37WNK31.26273358
38BMPR21.25468819
39ERBB31.20885343
40CLK11.19937472
41MAP3K21.14997305
42PRKCQ1.10042977
43CAMKK21.09064572
44IRAK11.07730119
45TRPM71.04190494
46MST1R1.03440208
47NUAK11.02600805
48PRKD31.01833828
49CSK1.01672232
50SGK20.97779464
51TBK10.97127292
52ITK0.95096663
53IRAK40.94696833
54IKBKE0.93065506
55SIK20.92224663
56ADRBK20.90570157
57MAP3K130.90469200
58PINK10.89922991
59SRPK10.87032619
60TNK20.86224670
61BRSK20.85564396
62LCK0.83478546
63MAP2K70.83349518
64TNIK0.80537156
65KSR10.80239310
66KDR0.80115266
67DYRK30.78972645
68PRKG20.73106514
69FGR0.72620714
70PRKCE0.71264244
71FES0.70755837
72SGK10.68962063
73PLK20.68559088
74STK30.67921399
75FGFR40.67857433
76TYK20.66356132
77DYRK1B0.64424865
78MST40.63725517
79SYK0.63056265
80JAK10.62760546
81PIK3CG0.62319925
82BLK0.62183396
83NTRK30.61994293
84CHUK0.61505328
85NEK60.60564544
86IKBKB0.59784352
87SGK2230.59609382
88SGK4940.59609382
89EGFR0.59352254
90MINK10.59031190
91YES10.58618158
92OXSR10.56667325
93NME10.55989202
94MAP4K10.55034186
95EPHA30.54706350
96EIF2AK10.54459089
97GRK50.54082007
98TAOK20.54069815
99STK380.53896703
100RPS6KB10.53460885
101KIT0.53052676
102MAPK70.52811762
103CSNK1G20.52710637
104EIF2AK20.52493487
105ACVR1B0.52395771
106PIM20.52360185
107STK38L0.51628613
108ATM0.50645187
109CAMK2A0.50484487
110GRK70.49329801
111TAOK10.49117190
112DAPK10.48703805
113CDK30.48549607
114PIM10.48252912
115PRKCG0.48057016
116INSRR0.47629348
117INSR0.47005645
118RPS6KA40.45996154
119ABL10.45805654
120DYRK1A0.45534616
121STK240.45262757
122CAMK1D0.44104090
123LYN0.44030090
124ARAF0.43269782
125STK160.43264506
126SIK30.42670456
127ATR0.42239374
128MAPKAPK30.41879127
129MAP3K10.41459565
130ZAP700.41446753
131FGFR30.41071769
132PRKCI0.41028169
133MAP2K40.40024443
134PDK10.39225216
135MARK30.38899634
136MAP3K40.37427790
137CDK60.37122622
138CDK90.36503955
139LMTK20.36443206
140PIK3CA0.34924473
141CSNK1E0.34729824
142CSNK1D0.34501147
143WEE10.34301544
144CHEK10.34110692
145CSF1R0.34107596
146BTK0.34003885
147GRK10.33866829
148RAF10.33275634
149PRKACB0.33273762
150MAP3K50.32510491
151IGF1R0.32464983
152PRKG10.31221052
153MAPK110.31071174
154PRKCZ0.30841223
155NLK0.30719010
156PAK30.30273816
157FER0.30075278
158PDGFRB0.29118406
159TYRO30.27721543
160RIPK10.27667079
161ADRBK10.27098856

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.28035679
2Circadian rhythm_Homo sapiens_hsa047102.83818645
3Pyruvate metabolism_Homo sapiens_hsa006202.75274965
4Sulfur metabolism_Homo sapiens_hsa009202.73713046
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.57359729
6Propanoate metabolism_Homo sapiens_hsa006402.44376340
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39915816
8Non-homologous end-joining_Homo sapiens_hsa034502.38707762
9Fanconi anemia pathway_Homo sapiens_hsa034602.25262215
10Primary immunodeficiency_Homo sapiens_hsa053402.21017880
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.17402173
12Phototransduction_Homo sapiens_hsa047442.16638621
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08355009
14Complement and coagulation cascades_Homo sapiens_hsa046101.92846294
15Dorso-ventral axis formation_Homo sapiens_hsa043201.90182181
16Oxidative phosphorylation_Homo sapiens_hsa001901.78126280
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.78120048
18RNA degradation_Homo sapiens_hsa030181.78101000
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.74191121
20Nicotine addiction_Homo sapiens_hsa050331.73681478
21Amphetamine addiction_Homo sapiens_hsa050311.72715209
22Alzheimers disease_Homo sapiens_hsa050101.65706497
23RNA transport_Homo sapiens_hsa030131.65647725
24Glucagon signaling pathway_Homo sapiens_hsa049221.63283052
25Renin secretion_Homo sapiens_hsa049241.63197739
26RNA polymerase_Homo sapiens_hsa030201.62363589
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58189704
28Huntingtons disease_Homo sapiens_hsa050161.57156557
29Homologous recombination_Homo sapiens_hsa034401.57019860
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56954369
31Histidine metabolism_Homo sapiens_hsa003401.56467743
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53439994
33Long-term potentiation_Homo sapiens_hsa047201.52424610
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47175957
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45267752
36Fatty acid biosynthesis_Homo sapiens_hsa000611.45012786
37T cell receptor signaling pathway_Homo sapiens_hsa046601.44112906
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38931049
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37927773
40Parkinsons disease_Homo sapiens_hsa050121.37782100
41Type I diabetes mellitus_Homo sapiens_hsa049401.35583906
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34241048
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29088477
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.28553657
45PPAR signaling pathway_Homo sapiens_hsa033201.27958792
46Tryptophan metabolism_Homo sapiens_hsa003801.26661761
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26283420
48Butanoate metabolism_Homo sapiens_hsa006501.24891120
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21921888
50Staphylococcus aureus infection_Homo sapiens_hsa051501.18089477
51B cell receptor signaling pathway_Homo sapiens_hsa046621.16203860
52Glycerolipid metabolism_Homo sapiens_hsa005611.15379935
53mRNA surveillance pathway_Homo sapiens_hsa030151.13969662
54ABC transporters_Homo sapiens_hsa020101.13835604
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13590634
56Olfactory transduction_Homo sapiens_hsa047401.09814550
57Bile secretion_Homo sapiens_hsa049761.08229899
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.08049860
59Fatty acid degradation_Homo sapiens_hsa000711.06258633
60Caffeine metabolism_Homo sapiens_hsa002321.05973779
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04938764
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04928781
63Hematopoietic cell lineage_Homo sapiens_hsa046401.03694608
64Chemical carcinogenesis_Homo sapiens_hsa052041.02826688
65Graft-versus-host disease_Homo sapiens_hsa053321.00153715
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99219281
67Allograft rejection_Homo sapiens_hsa053300.97967455
68Autoimmune thyroid disease_Homo sapiens_hsa053200.97685824
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97479241
70Cell cycle_Homo sapiens_hsa041100.96494594
71Osteoclast differentiation_Homo sapiens_hsa043800.95111270
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93804999
73Peroxisome_Homo sapiens_hsa041460.93374003
74Antigen processing and presentation_Homo sapiens_hsa046120.91667750
75Morphine addiction_Homo sapiens_hsa050320.89453138
76Tyrosine metabolism_Homo sapiens_hsa003500.87646628
77Measles_Homo sapiens_hsa051620.87367268
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86951922
79Collecting duct acid secretion_Homo sapiens_hsa049660.86782079
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85452630
81Type II diabetes mellitus_Homo sapiens_hsa049300.85411627
82Fat digestion and absorption_Homo sapiens_hsa049750.85377197
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84684168
84Linoleic acid metabolism_Homo sapiens_hsa005910.84471313
85Basal transcription factors_Homo sapiens_hsa030220.84151525
86FoxO signaling pathway_Homo sapiens_hsa040680.82994826
87Starch and sucrose metabolism_Homo sapiens_hsa005000.82517812
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78941355
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78868754
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78201834
91Base excision repair_Homo sapiens_hsa034100.78085420
92p53 signaling pathway_Homo sapiens_hsa041150.77638058
93Mineral absorption_Homo sapiens_hsa049780.76434454
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76171908
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76043942
96Thyroid hormone synthesis_Homo sapiens_hsa049180.73773382
97Phenylalanine metabolism_Homo sapiens_hsa003600.69179156
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68842079
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66363709
100Taste transduction_Homo sapiens_hsa047420.65683958
101Dopaminergic synapse_Homo sapiens_hsa047280.64738116
102Selenocompound metabolism_Homo sapiens_hsa004500.64730630
103Platelet activation_Homo sapiens_hsa046110.64343507
104Arginine biosynthesis_Homo sapiens_hsa002200.61402870
105Asthma_Homo sapiens_hsa053100.60988334
106Epstein-Barr virus infection_Homo sapiens_hsa051690.59412325
107Legionellosis_Homo sapiens_hsa051340.58789719
108GABAergic synapse_Homo sapiens_hsa047270.58608379
109Oocyte meiosis_Homo sapiens_hsa041140.57475127
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.57441277
111Herpes simplex infection_Homo sapiens_hsa051680.56880785
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.56274598
113Retinol metabolism_Homo sapiens_hsa008300.55891839
114Rheumatoid arthritis_Homo sapiens_hsa053230.51979862
115Leishmaniasis_Homo sapiens_hsa051400.51548241
116Steroid biosynthesis_Homo sapiens_hsa001000.51488707
117Salivary secretion_Homo sapiens_hsa049700.50083259
118Vibrio cholerae infection_Homo sapiens_hsa051100.49602183
119Tuberculosis_Homo sapiens_hsa051520.49474762
120Pancreatic secretion_Homo sapiens_hsa049720.49416551
121Sulfur relay system_Homo sapiens_hsa041220.49168837
122Calcium signaling pathway_Homo sapiens_hsa040200.49150141
123Ether lipid metabolism_Homo sapiens_hsa005650.48750989
124Pentose phosphate pathway_Homo sapiens_hsa000300.48705865
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.48422346
126Long-term depression_Homo sapiens_hsa047300.47748510
127Salmonella infection_Homo sapiens_hsa051320.47435462
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46669481
129Regulation of autophagy_Homo sapiens_hsa041400.44405157
130Insulin secretion_Homo sapiens_hsa049110.44315270
131Serotonergic synapse_Homo sapiens_hsa047260.44013518
132Spliceosome_Homo sapiens_hsa030400.42696637
133Nucleotide excision repair_Homo sapiens_hsa034200.42233786
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42121926
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41683413
136Circadian entrainment_Homo sapiens_hsa047130.41598471
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41010209
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.40874834
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.39890059
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.39706326
141Malaria_Homo sapiens_hsa051440.39428767
142Estrogen signaling pathway_Homo sapiens_hsa049150.39235334
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39118518
144Fatty acid metabolism_Homo sapiens_hsa012120.38780676
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38555915
146cAMP signaling pathway_Homo sapiens_hsa040240.38533924
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38385796
148Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38289348
149Hepatitis B_Homo sapiens_hsa051610.37584614
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35872112
151Influenza A_Homo sapiens_hsa051640.35766649
152MAPK signaling pathway_Homo sapiens_hsa040100.35711135
153Shigellosis_Homo sapiens_hsa051310.35237328
154Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35178205

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