GGPS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)4.14795429
2chaperone-mediated protein transport (GO:0072321)4.14385445
3positive regulation of protein homodimerization activity (GO:0090073)3.99464320
4presynaptic membrane assembly (GO:0097105)3.98443140
5protein deneddylation (GO:0000338)3.98288763
6protein neddylation (GO:0045116)3.91051072
7neuron cell-cell adhesion (GO:0007158)3.80361280
8presynaptic membrane organization (GO:0097090)3.74285633
9axon ensheathment in central nervous system (GO:0032291)3.68467023
10central nervous system myelination (GO:0022010)3.68467023
11L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.61327548
12respiratory chain complex IV assembly (GO:0008535)3.56196709
13intraciliary transport (GO:0042073)3.55226576
14establishment of integrated proviral latency (GO:0075713)3.52823912
15DNA double-strand break processing (GO:0000729)3.50010169
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.49024568
17transcription elongation from RNA polymerase III promoter (GO:0006385)3.46143078
18termination of RNA polymerase III transcription (GO:0006386)3.46143078
19DNA deamination (GO:0045006)3.45489250
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37914790
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28558907
22ATP synthesis coupled proton transport (GO:0015986)3.28558907
23behavioral response to nicotine (GO:0035095)3.24460110
24maturation of 5.8S rRNA (GO:0000460)3.23222146
25cytochrome complex assembly (GO:0017004)3.17029634
26long-chain fatty acid biosynthetic process (GO:0042759)3.15177273
27platelet dense granule organization (GO:0060155)3.14760804
28branched-chain amino acid catabolic process (GO:0009083)3.11850205
29GTP biosynthetic process (GO:0006183)3.09470642
30cornea development in camera-type eye (GO:0061303)3.09410148
317-methylguanosine mRNA capping (GO:0006370)3.09299171
327-methylguanosine RNA capping (GO:0009452)3.09238287
33RNA capping (GO:0036260)3.09238287
34chromatin remodeling at centromere (GO:0031055)3.08651276
35startle response (GO:0001964)3.08384313
36L-methionine biosynthetic process (GO:0071265)3.05310069
37amino acid salvage (GO:0043102)3.05310069
38L-methionine salvage (GO:0071267)3.05310069
39negative regulation of neurotransmitter transport (GO:0051589)3.02838824
40protein K11-linked ubiquitination (GO:0070979)3.01727973
41establishment of viral latency (GO:0019043)3.00830897
42CENP-A containing nucleosome assembly (GO:0034080)3.00313797
43establishment of protein localization to mitochondrial membrane (GO:0090151)2.97972793
44regulation of mitochondrial translation (GO:0070129)2.97413977
45nonmotile primary cilium assembly (GO:0035058)2.97356913
46kinetochore assembly (GO:0051382)2.95641418
47deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.94748330
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93940028
49limb bud formation (GO:0060174)2.93881011
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93794285
51mitochondrial respiratory chain complex I assembly (GO:0032981)2.93794285
52NADH dehydrogenase complex assembly (GO:0010257)2.93794285
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90478851
54ribosomal small subunit biogenesis (GO:0042274)2.89817419
55protein complex biogenesis (GO:0070271)2.88863594
56regulation of cilium movement (GO:0003352)2.86644417
57negative regulation of protein localization to cell surface (GO:2000009)2.85066994
58transcription elongation from RNA polymerase I promoter (GO:0006362)2.84131213
59neuronal action potential propagation (GO:0019227)2.83313253
60ionotropic glutamate receptor signaling pathway (GO:0035235)2.80657150
61negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79799369
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77895141
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.76827336
64glutamate receptor signaling pathway (GO:0007215)2.76584129
65spliceosomal complex assembly (GO:0000245)2.75351160
66protein-cofactor linkage (GO:0018065)2.74580440
67response to pheromone (GO:0019236)2.73833553
68L-fucose catabolic process (GO:0042355)2.72401541
69fucose catabolic process (GO:0019317)2.72401541
70L-fucose metabolic process (GO:0042354)2.72401541
71natural killer cell activation involved in immune response (GO:0002323)2.71343527
72preassembly of GPI anchor in ER membrane (GO:0016254)2.70607043
73termination of RNA polymerase I transcription (GO:0006363)2.69583607
74gamma-aminobutyric acid signaling pathway (GO:0007214)2.69018049
75postsynaptic membrane organization (GO:0001941)2.67341873
76histone mRNA metabolic process (GO:0008334)2.64265198
77histone H2B ubiquitination (GO:0033523)2.63764480
78neuron recognition (GO:0008038)2.63672059
79fatty acid elongation (GO:0030497)2.63147595
80cilium morphogenesis (GO:0060271)2.62760422
81GPI anchor biosynthetic process (GO:0006506)2.62613150
82somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61907431
83isotype switching (GO:0045190)2.61907431
84somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61907431
85rRNA modification (GO:0000154)2.60840232
86regulation of respiratory system process (GO:0044065)2.60472884
87positive regulation of synapse assembly (GO:0051965)2.59990545
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59691281
89negative regulation of ligase activity (GO:0051352)2.59691281
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59543691
91response to redox state (GO:0051775)2.59153643
92respiratory electron transport chain (GO:0022904)2.58900663
93regulation of cellular amino acid metabolic process (GO:0006521)2.58080134
94signal peptide processing (GO:0006465)2.57893143
95kinetochore organization (GO:0051383)2.56937462
96aldehyde catabolic process (GO:0046185)2.56907526
97regulation of feeding behavior (GO:0060259)2.56411574
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55109822
99neuron-neuron synaptic transmission (GO:0007270)2.54855369
100mannosylation (GO:0097502)2.54790635
101regulation of timing of cell differentiation (GO:0048505)2.54429143
102negative regulation of DNA-dependent DNA replication (GO:2000104)2.54091212
103regulation of vesicle fusion (GO:0031338)2.53861594
104protein localization to synapse (GO:0035418)2.53445883
105S-adenosylmethionine metabolic process (GO:0046500)2.53407362
106viral protein processing (GO:0019082)2.53089462
107electron transport chain (GO:0022900)2.53038475
108anterograde synaptic vesicle transport (GO:0048490)2.52176582
109positive regulation of mitochondrial fission (GO:0090141)2.51499264
110histone exchange (GO:0043486)2.50552151
111proteasome assembly (GO:0043248)2.50427613
112methionine biosynthetic process (GO:0009086)2.50190549
113epithelial cilium movement (GO:0003351)2.49508063
114regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.49412654
115hydrogen ion transmembrane transport (GO:1902600)2.49339577
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48527346
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48378411
118peptidyl-histidine modification (GO:0018202)2.47875945
119regulation of rhodopsin mediated signaling pathway (GO:0022400)2.47858437
120organelle disassembly (GO:1903008)2.47813557
121glycerophospholipid catabolic process (GO:0046475)2.47777422
122positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.47549784
123transcription from RNA polymerase I promoter (GO:0006360)2.47380977
124inositol phosphate catabolic process (GO:0071545)2.47008986
125guanosine-containing compound biosynthetic process (GO:1901070)2.46817663
126synaptic transmission, glutamatergic (GO:0035249)2.46474515
127negative regulation of neurotransmitter secretion (GO:0046929)2.45582426
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.45547318
129signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.45547318
130signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.45547318
131rRNA methylation (GO:0031167)2.45089260
132regulation of respiratory gaseous exchange (GO:0043576)2.44991306
133mitochondrial respiratory chain complex assembly (GO:0033108)2.44943738
134oxidative phosphorylation (GO:0006119)2.44704834
135protein localization to cilium (GO:0061512)2.44048171
136regulation of meiosis I (GO:0060631)2.43095009
137UTP biosynthetic process (GO:0006228)2.42809262
138resolution of meiotic recombination intermediates (GO:0000712)2.42347313
139negative regulation of transcription regulatory region DNA binding (GO:2000678)2.41961083
140tRNA processing (GO:0008033)2.41787713
141microtubule polymerization or depolymerization (GO:0031109)2.41778407
142regulation of dopamine metabolic process (GO:0042053)2.41264002
143regulation of catecholamine metabolic process (GO:0042069)2.41264002
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40836837
145cerebral cortex radially oriented cell migration (GO:0021799)2.40611340
146signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.40594510
147intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.40594510
148dendrite development (GO:0016358)2.40540309
149DNA damage response, detection of DNA damage (GO:0042769)2.39738756
150regulation of development, heterochronic (GO:0040034)2.38769605
151detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38734850
152positive regulation of ligase activity (GO:0051351)2.38325608
153inositol phosphate dephosphorylation (GO:0046855)2.38179153
154phosphorylated carbohydrate dephosphorylation (GO:0046838)2.38179153
155nucleoside diphosphate catabolic process (GO:0009134)2.37487370
156transcription initiation from RNA polymerase I promoter (GO:0006361)2.37198257
157GPI anchor metabolic process (GO:0006505)2.36704350
158cullin deneddylation (GO:0010388)2.36314074
159rhodopsin mediated signaling pathway (GO:0016056)2.33390511
160dopamine transport (GO:0015872)2.33344992
161neurotransmitter uptake (GO:0001504)2.32728816
162maturation of SSU-rRNA (GO:0030490)2.32464479
163positive regulation of response to oxidative stress (GO:1902884)2.31548809
164positive regulation of cellular response to oxidative stress (GO:1900409)2.31548809
165transmission of nerve impulse (GO:0019226)2.29486888
166regulation of glutamate secretion (GO:0014048)2.28734490
167spliceosomal snRNP assembly (GO:0000387)2.28063780
168developmental pigmentation (GO:0048066)2.27815655
169exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.27750398
170RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.26131866
171tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.26131866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.68332487
2EZH2_22144423_ChIP-Seq_EOC_Human3.29173759
3ZNF274_21170338_ChIP-Seq_K562_Hela3.15075129
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87908547
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55741933
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51789529
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50718938
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47524174
9VDR_22108803_ChIP-Seq_LS180_Human2.46811842
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40145601
11TAF15_26573619_Chip-Seq_HEK293_Human2.33251097
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26900996
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.22268154
14FUS_26573619_Chip-Seq_HEK293_Human2.15948495
15* SALL1_21062744_ChIP-ChIP_HESCs_Human2.11705209
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.10835977
17* EST1_17652178_ChIP-ChIP_JURKAT_Human1.99361708
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97179074
19MYC_18940864_ChIP-ChIP_HL60_Human1.94136860
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93367259
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91805498
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90781920
23FOXP3_21729870_ChIP-Seq_TREG_Human1.84409162
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81995503
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81342570
26* SRF_21415370_ChIP-Seq_HL-1_Mouse1.80940308
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80580605
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79960887
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79424771
30P300_19829295_ChIP-Seq_ESCs_Human1.77825760
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77012457
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76437578
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76401689
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74195778
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73576388
36ER_23166858_ChIP-Seq_MCF-7_Human1.73090865
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.72350885
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71515901
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.65473687
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63201134
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.63035387
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59401673
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55074489
44RNF2_27304074_Chip-Seq_NSC_Mouse1.53168333
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.51364400
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50747550
47EWS_26573619_Chip-Seq_HEK293_Human1.50628279
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50515503
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.50030598
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.49152822
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48727395
52* ELK1_19687146_ChIP-ChIP_HELA_Human1.48691677
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47503011
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47217471
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46423736
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45007700
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43201847
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41072566
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39828459
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.39641008
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36224958
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36015240
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34789388
64IRF1_19129219_ChIP-ChIP_H3396_Human1.33869395
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.33578716
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.33296396
67* ETS1_20019798_ChIP-Seq_JURKAT_Human1.33170123
68* TP53_22573176_ChIP-Seq_HFKS_Human1.33052039
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.33025447
70REST_21632747_ChIP-Seq_MESCs_Mouse1.32087389
71SMAD4_21799915_ChIP-Seq_A2780_Human1.30953221
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28383862
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27847496
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27713850
75IGF1R_20145208_ChIP-Seq_DFB_Human1.27710184
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.27171653
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27152477
78GABP_19822575_ChIP-Seq_HepG2_Human1.27144810
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26830227
80EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25971549
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.25613241
82P53_22387025_ChIP-Seq_ESCs_Mouse1.25612832
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25419471
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25192068
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23137421
86DCP1A_22483619_ChIP-Seq_HELA_Human1.23022247
87P300_18555785_Chip-Seq_ESCs_Mouse1.22971229
88CBP_20019798_ChIP-Seq_JUKART_Human1.21878399
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21878399
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21621908
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21594369
92AR_21572438_ChIP-Seq_LNCaP_Human1.21430432
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20677614
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20573979
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20183840
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19043024
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.18311563
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18140454
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.17994032
100EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15891009
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15891009
102TTF2_22483619_ChIP-Seq_HELA_Human1.15750968
103SOX2_19829295_ChIP-Seq_ESCs_Human1.15085000
104NANOG_19829295_ChIP-Seq_ESCs_Human1.15085000
105* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14207332
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13248054
107AR_20517297_ChIP-Seq_VCAP_Human1.13181160
108CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12726709
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12650918
110RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12626505
111FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12209335
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.12209335
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.10786139
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.10068372
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10049635
116HTT_18923047_ChIP-ChIP_STHdh_Human1.07130050
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07017917
118MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06856148
119KLF4_18555785_Chip-Seq_ESCs_Mouse1.05029820
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04854962
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04127102
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03035755
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03010710
124ZFX_18555785_Chip-Seq_ESCs_Mouse1.02916658
125* SOX2_16153702_ChIP-ChIP_HESCs_Human1.02683207
126EZH2_27294783_Chip-Seq_NPCs_Mouse1.02151552
127PIAS1_25552417_ChIP-Seq_VCAP_Human1.01883409
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01233872
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01233872
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.00201920
131CRX_20693478_ChIP-Seq_RETINA_Mouse0.99812445
132OCT4_18555785_Chip-Seq_ESCs_Mouse0.99402449
133SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99387297
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99220130
135EZH2_27294783_Chip-Seq_ESCs_Mouse0.98962232
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98152952
137MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98148377
138VDR_23849224_ChIP-Seq_CD4+_Human0.97960839
139KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97900793
140SOX9_26525672_Chip-Seq_HEART_Mouse0.97899378
141* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97457080
142ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96595439
143NANOG_16153702_ChIP-ChIP_HESCs_Human0.95262864
144FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93686641
145BCAT_22108803_ChIP-Seq_LS180_Human0.93308676
146AR_25329375_ChIP-Seq_VCAP_Human0.91064021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.58243126
2MP0001188_hyperpigmentation3.06171306
3MP0006292_abnormal_olfactory_placode3.03664639
4MP0005423_abnormal_somatic_nervous2.83076169
5MP0003136_yellow_coat_color2.69651365
6MP0009379_abnormal_foot_pigmentation2.67760787
7MP0005171_absent_coat_pigmentation2.49847139
8MP0001986_abnormal_taste_sensitivity2.49002021
9MP0005409_darkened_coat_color2.23794873
10MP0004147_increased_porphyrin_level2.20022754
11MP0004859_abnormal_synaptic_plasticity2.17699299
12MP0003787_abnormal_imprinting2.17102038
13MP0006276_abnormal_autonomic_nervous2.15974281
14MP0001529_abnormal_vocalization2.14534069
15MP0001968_abnormal_touch/_nociception2.13354087
16MP0004270_analgesia2.12911013
17MP0009745_abnormal_behavioral_response2.12666266
18MP0003635_abnormal_synaptic_transmissio2.11024930
19MP0001905_abnormal_dopamine_level2.05600657
20MP0002064_seizures2.04198106
21MP0009697_abnormal_copulation2.03345007
22MP0008877_abnormal_DNA_methylation2.01341567
23MP0002272_abnormal_nervous_system1.95032614
24MP0002735_abnormal_chemical_nociception1.92715334
25MP0002572_abnormal_emotion/affect_behav1.90148285
26MP0002736_abnormal_nociception_after1.89387795
27MP0002638_abnormal_pupillary_reflex1.85124678
28MP0000566_synostosis1.82363644
29MP0002063_abnormal_learning/memory/cond1.80374646
30MP0005084_abnormal_gallbladder_morpholo1.79001436
31MP0001486_abnormal_startle_reflex1.78027921
32MP0002734_abnormal_mechanical_nocicepti1.77472503
33MP0009046_muscle_twitch1.76172070
34MP0002163_abnormal_gland_morphology1.75402225
35MP0000778_abnormal_nervous_system1.73101924
36MP0001293_anophthalmia1.70978148
37MP0005075_abnormal_melanosome_morpholog1.67670093
38MP0002234_abnormal_pharynx_morphology1.66498892
39MP0004145_abnormal_muscle_electrophysio1.64336600
40MP0003011_delayed_dark_adaptation1.64155023
41MP0004142_abnormal_muscle_tone1.63356108
42MP0003786_premature_aging1.62609382
43MP0000372_irregular_coat_pigmentation1.58346750
44MP0002837_dystrophic_cardiac_calcinosis1.56960754
45MP0002184_abnormal_innervation1.52403068
46MP0005379_endocrine/exocrine_gland_phen1.51317043
47MP0005551_abnormal_eye_electrophysiolog1.50191902
48MP0006036_abnormal_mitochondrial_physio1.49177686
49MP0008995_early_reproductive_senescence1.48276391
50MP0002067_abnormal_sensory_capabilities1.48115965
51MP0003195_calcinosis1.47757233
52MP0010094_abnormal_chromosome_stability1.46570333
53MP0005646_abnormal_pituitary_gland1.40404438
54MP0010386_abnormal_urinary_bladder1.38976709
55MP0001970_abnormal_pain_threshold1.37396266
56MP0003693_abnormal_embryo_hatching1.36229857
57MP0006072_abnormal_retinal_apoptosis1.36213366
58MP0004742_abnormal_vestibular_system1.34403808
59MP0001440_abnormal_grooming_behavior1.34207122
60MP0005187_abnormal_penis_morphology1.30513104
61MP0005389_reproductive_system_phenotype1.30303477
62MP0003937_abnormal_limbs/digits/tail_de1.30228541
63MP0005645_abnormal_hypothalamus_physiol1.28138428
64MP0001501_abnormal_sleep_pattern1.27288416
65MP0002254_reproductive_system_inflammat1.25417718
66MP0001984_abnormal_olfaction1.24213239
67MP0001919_abnormal_reproductive_system1.23697308
68MP0001764_abnormal_homeostasis1.23506727
69MP0000427_abnormal_hair_cycle1.23179392
70MP0003121_genomic_imprinting1.22813600
71MP0002751_abnormal_autonomic_nervous1.22474172
72MP0002733_abnormal_thermal_nociception1.21696904
73MP0008057_abnormal_DNA_replication1.20410711
74MP0008007_abnormal_cellular_replicative1.19520169
75MP0003186_abnormal_redox_activity1.19311191
76MP0005253_abnormal_eye_physiology1.18252526
77MP0002557_abnormal_social/conspecific_i1.17084759
78MP0006035_abnormal_mitochondrial_morpho1.15778368
79MP0004957_abnormal_blastocyst_morpholog1.13661648
80MP0001324_abnormal_eye_pigmentation1.13330352
81MP0003122_maternal_imprinting1.12907727
82MP0001963_abnormal_hearing_physiology1.11489342
83MP0000516_abnormal_urinary_system1.11130560
84MP0005367_renal/urinary_system_phenotyp1.11130560
85MP0002876_abnormal_thyroid_physiology1.11014239
86MP0008872_abnormal_physiological_respon1.10956837
87MP0002653_abnormal_ependyma_morphology1.10813105
88MP0004133_heterotaxia1.10067951
89MP0002752_abnormal_somatic_nervous1.08840367
90MP0000631_abnormal_neuroendocrine_gland1.08509240
91MP0001485_abnormal_pinna_reflex1.07709616
92MP0000647_abnormal_sebaceous_gland1.07695169
93MP0002277_abnormal_respiratory_mucosa1.07543896
94MP0005408_hypopigmentation1.07287736
95MP0003567_abnormal_fetal_cardiomyocyte1.06764337
96MP0004885_abnormal_endolymph1.06211293
97MP0003890_abnormal_embryonic-extraembry1.05937255
98MP0002882_abnormal_neuron_morphology1.05356187
99MP0004381_abnormal_hair_follicle1.05159979
100MP0004924_abnormal_behavior1.03528868
101MP0005386_behavior/neurological_phenoty1.03528868
102MP0002822_catalepsy1.02886346
103MP0000955_abnormal_spinal_cord1.02369036
104MP0005174_abnormal_tail_pigmentation1.01838949
105MP0000920_abnormal_myelination1.00431420
106MP0000026_abnormal_inner_ear0.99586513
107MP0002233_abnormal_nose_morphology0.99171534
108MP0005391_vision/eye_phenotype0.98039213
109MP0003119_abnormal_digestive_system0.97127950
110MP0004215_abnormal_myocardial_fiber0.96875212
111MP0003806_abnormal_nucleotide_metabolis0.95897611
112MP0008789_abnormal_olfactory_epithelium0.95131511
113MP0001286_abnormal_eye_development0.94073360
114MP0003718_maternal_effect0.93615484
115MP0002102_abnormal_ear_morphology0.92853342
116MP0001929_abnormal_gametogenesis0.92724470
117MP0000569_abnormal_digit_pigmentation0.92479869
118MP0002095_abnormal_skin_pigmentation0.92268094
119MP0002210_abnormal_sex_determination0.91775687
120MP0003938_abnormal_ear_development0.90910755
121MP0000653_abnormal_sex_gland0.90571596
122MP0001502_abnormal_circadian_rhythm0.88577448
123MP0000613_abnormal_salivary_gland0.88536834
124MP0005394_taste/olfaction_phenotype0.88472530
125MP0005499_abnormal_olfactory_system0.88472530
126MP0002938_white_spotting0.86198382
127MP0003950_abnormal_plasma_membrane0.85137363
128MP0002066_abnormal_motor_capabilities/c0.85076041
129MP0002090_abnormal_vision0.84996019
130MP0003698_abnormal_male_reproductive0.84025010
131MP0000049_abnormal_middle_ear0.83472370
132MP0003111_abnormal_nucleus_morphology0.82642918
133MP0000015_abnormal_ear_pigmentation0.81343104
134MP0001145_abnormal_male_reproductive0.80217309
135MP0009780_abnormal_chondrocyte_physiolo0.78572385
136MP0002229_neurodegeneration0.78007463
137MP0008569_lethality_at_weaning0.76297603
138MP0002152_abnormal_brain_morphology0.76208803
139MP0008058_abnormal_DNA_repair0.75813465
140MP0003941_abnormal_skin_development0.72281035
141MP0003123_paternal_imprinting0.72128638
142MP0002160_abnormal_reproductive_system0.70767463
143MP0008932_abnormal_embryonic_tissue0.69978645
144MP0003315_abnormal_perineum_morphology0.69094033
145MP0003634_abnormal_glial_cell0.68089726
146MP0000762_abnormal_tongue_morphology0.65524056
147MP0005195_abnormal_posterior_eye0.63995412
148MP0004811_abnormal_neuron_physiology0.63416714
149MP0003755_abnormal_palate_morphology0.62642153
150MP0003861_abnormal_nervous_system0.62474400
151MP0004134_abnormal_chest_morphology0.61405517
152MP0008260_abnormal_autophagy0.60554079
153MP0005410_abnormal_fertilization0.58869316

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.78946415
2Focal motor seizures (HP:0011153)3.50255251
3Progressive macrocephaly (HP:0004481)3.27093565
4Abnormal mitochondria in muscle tissue (HP:0008316)3.14849291
5Duplicated collecting system (HP:0000081)3.10441627
6Mitochondrial inheritance (HP:0001427)3.05757607
7Methylmalonic acidemia (HP:0002912)2.98650736
8Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.95061754
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.91820651
10Medial flaring of the eyebrow (HP:0010747)2.88988919
11Broad-based gait (HP:0002136)2.87352820
12Abnormal hair whorl (HP:0010721)2.84793846
13Nephronophthisis (HP:0000090)2.84281463
14Atonic seizures (HP:0010819)2.76742433
15Hepatic necrosis (HP:0002605)2.73662090
16Optic disc pallor (HP:0000543)2.72999428
17Gait imbalance (HP:0002141)2.71120438
18Epileptic encephalopathy (HP:0200134)2.69080350
19Acute encephalopathy (HP:0006846)2.68395779
20Abnormality of the renal collecting system (HP:0004742)2.68151272
21Abnormality of alanine metabolism (HP:0010916)2.64241114
22Hyperalaninemia (HP:0003348)2.64241114
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64241114
24Febrile seizures (HP:0002373)2.63521043
25Congenital primary aphakia (HP:0007707)2.61155031
26Colon cancer (HP:0003003)2.58927256
27Abnormality of the renal cortex (HP:0011035)2.57465968
28Hyperglycinemia (HP:0002154)2.57199233
29Parakeratosis (HP:0001036)2.57149718
30Methylmalonic aciduria (HP:0012120)2.54642687
31Nephrogenic diabetes insipidus (HP:0009806)2.53175097
32Cerebral edema (HP:0002181)2.50802353
33Hypothermia (HP:0002045)2.49870747
34Renal Fanconi syndrome (HP:0001994)2.47751328
35Congenital stationary night blindness (HP:0007642)2.47699738
36Increased CSF lactate (HP:0002490)2.45331869
37Increased hepatocellular lipid droplets (HP:0006565)2.43849490
38Progressive cerebellar ataxia (HP:0002073)2.43763338
39Abnormality of secondary sexual hair (HP:0009888)2.43489930
40Abnormality of the axillary hair (HP:0100134)2.43489930
41Renal cortical cysts (HP:0000803)2.41780270
42Increased serum lactate (HP:0002151)2.41480032
43Abolished electroretinogram (ERG) (HP:0000550)2.40982965
44Abnormality of the renal medulla (HP:0100957)2.35915989
45Genital tract atresia (HP:0001827)2.33127228
46Pancreatic fibrosis (HP:0100732)2.31628556
47Vaginal atresia (HP:0000148)2.31288303
483-Methylglutaconic aciduria (HP:0003535)2.31041267
49True hermaphroditism (HP:0010459)2.30585241
50Septo-optic dysplasia (HP:0100842)2.27350331
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26580389
52Hyperglycinuria (HP:0003108)2.26280450
53Lactic acidosis (HP:0003128)2.26236164
54Abnormality of macular pigmentation (HP:0008002)2.22222718
55Abnormal ciliary motility (HP:0012262)2.20933403
56Congenital, generalized hypertrichosis (HP:0004540)2.20415321
57Type II lissencephaly (HP:0007260)2.20281021
58Cerebral hypomyelination (HP:0006808)2.19426699
59Abnormality of serum amino acid levels (HP:0003112)2.18620766
60Hypoplasia of the fovea (HP:0007750)2.18582951
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.18582951
62Abnormality of incisor morphology (HP:0011063)2.18391804
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.16138876
64Absent/shortened dynein arms (HP:0200106)2.16138876
65Hyperventilation (HP:0002883)2.14183894
66Pancreatic cysts (HP:0001737)2.13783230
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10829545
68Irregular epiphyses (HP:0010582)2.10398328
69Sclerocornea (HP:0000647)2.08689113
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06476642
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06476642
72Abnormality of serine family amino acid metabolism (HP:0010894)2.06336183
73Abnormality of glycine metabolism (HP:0010895)2.06336183
74Increased intramyocellular lipid droplets (HP:0012240)2.05810939
75Lethargy (HP:0001254)2.05555332
76Postaxial foot polydactyly (HP:0001830)2.05037133
77Respiratory failure (HP:0002878)2.02703098
78Abnormal respiratory motile cilium morphology (HP:0005938)2.02435783
79Abnormal respiratory epithelium morphology (HP:0012253)2.02435783
80Pendular nystagmus (HP:0012043)2.02098459
81Anencephaly (HP:0002323)2.01792419
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01651256
83Progressive external ophthalmoplegia (HP:0000590)2.01246051
84Oligodactyly (hands) (HP:0001180)2.00789332
85Abnormality of methionine metabolism (HP:0010901)1.98602493
86Exercise intolerance (HP:0003546)1.98554970
87Chronic hepatic failure (HP:0100626)1.98538190
88Hepatocellular necrosis (HP:0001404)1.98346226
89Focal seizures (HP:0007359)1.98291382
90Leukodystrophy (HP:0002415)1.97879084
91Thickened helices (HP:0000391)1.97173491
92Conical tooth (HP:0000698)1.95965251
93Postaxial hand polydactyly (HP:0001162)1.93654739
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92244767
95Attenuation of retinal blood vessels (HP:0007843)1.91567284
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.90034236
97Poor coordination (HP:0002370)1.88781834
98Exertional dyspnea (HP:0002875)1.88573119
99Retinal dysplasia (HP:0007973)1.88192092
100Meckel diverticulum (HP:0002245)1.87886095
101Absence seizures (HP:0002121)1.87736126
102Abnormality of the fovea (HP:0000493)1.87642303
103Abnormality of renal resorption (HP:0011038)1.87342799
104Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87194679
105Aplasia/hypoplasia of the uterus (HP:0008684)1.85689576
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.85059838
107Dialeptic seizures (HP:0011146)1.83964104
108Abnormal respiratory motile cilium physiology (HP:0012261)1.83350504
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.82128254
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82128254
111Decreased central vision (HP:0007663)1.82065637
112Aplasia/Hypoplasia of the lens (HP:0008063)1.81481960
113Myokymia (HP:0002411)1.81283058
114Abnormality of vitamin B metabolism (HP:0004340)1.80503894
115Type I transferrin isoform profile (HP:0003642)1.79966864
116Abnormality of the ileum (HP:0001549)1.79688022
117Abnormality of the septum pellucidum (HP:0007375)1.78592388
118Tubular atrophy (HP:0000092)1.78141886
119Optic nerve hypoplasia (HP:0000609)1.77792183
120Abnormality of the labia minora (HP:0012880)1.77741553
121Increased muscle lipid content (HP:0009058)1.76949178
122Absent eyebrow (HP:0002223)1.76669498
123Protruding tongue (HP:0010808)1.76045657
124Esotropia (HP:0000565)1.75300453
125Reticulocytopenia (HP:0001896)1.73420002
126Aplasia/Hypoplasia of the tibia (HP:0005772)1.73042680
127Supernumerary spleens (HP:0009799)1.72833574
128Chromsome breakage (HP:0040012)1.72375655
129Abnormality of the pons (HP:0007361)1.72214296
130Adrenal hypoplasia (HP:0000835)1.71801926
131Abnormality of urine glucose concentration (HP:0011016)1.71726906
132Glycosuria (HP:0003076)1.71726906
133Occipital encephalocele (HP:0002085)1.71423824
134Male pseudohermaphroditism (HP:0000037)1.71283436
135Hypoplastic pelvis (HP:0008839)1.70461888
136Drooling (HP:0002307)1.69947379
137Excessive salivation (HP:0003781)1.69947379
138Abnormal protein glycosylation (HP:0012346)1.69345614
139Abnormal glycosylation (HP:0012345)1.69345614
140Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69345614
141Abnormal protein N-linked glycosylation (HP:0012347)1.69345614
142Absent radius (HP:0003974)1.68214628
143Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66706967
144Limb dystonia (HP:0002451)1.65639357
145Hypoplastic nipples (HP:0002557)1.65380797
146Preaxial hand polydactyly (HP:0001177)1.64259857
147Gaze-evoked nystagmus (HP:0000640)1.64190249
148Lipid accumulation in hepatocytes (HP:0006561)1.63955929
149Split foot (HP:0001839)1.63928979
150Cupped ear (HP:0000378)1.63715300
151Astigmatism (HP:0000483)1.63662765
152Nasolacrimal duct obstruction (HP:0000579)1.63613265
153Aplasia involving forearm bones (HP:0009822)1.62895807
154Absent forearm bone (HP:0003953)1.62895807
155Absent septum pellucidum (HP:0001331)1.61595043
156Severe visual impairment (HP:0001141)1.61322428
157Gastroesophageal reflux (HP:0002020)1.60609102
158Increased serum pyruvate (HP:0003542)1.60356807
159Abnormality of glycolysis (HP:0004366)1.60356807
160Submucous cleft hard palate (HP:0000176)1.59458198
161Aganglionic megacolon (HP:0002251)1.59392730
162Molar tooth sign on MRI (HP:0002419)1.58832570
163Abnormality of midbrain morphology (HP:0002418)1.58832570
164Short tibia (HP:0005736)1.58672819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.49812033
2TRIM283.16661591
3STK162.66055679
4MAP4K22.48144541
5FRK2.46220705
6VRK22.20243102
7EPHA42.19085733
8MARK12.06991278
9SRPK12.00976868
10MAP2K72.00849250
11AKT31.99919150
12NME11.92678496
13PBK1.91135524
14VRK11.87604973
15NTRK31.87366681
16IRAK31.79677121
17MAP3K121.79346967
18TNIK1.78531172
19PLK21.76163239
20BRSK21.75869930
21PNCK1.70579554
22BMPR21.69571478
23BCR1.67963223
24STK391.65684606
25BUB11.62004338
26IRAK21.61389121
27CSNK1G11.56170367
28MST41.55420003
29IRAK41.52108006
30TAOK31.50927698
31NEK61.50682474
32BMPR1B1.50370743
33NEK11.48035170
34PRPF4B1.41042941
35OXSR11.39757004
36MAPK131.36428188
37EIF2AK31.34224875
38ZAK1.34035875
39MAP3K41.33120418
40MKNK21.32286183
41ADRBK21.32084872
42TLK11.31690906
43PLK41.27898988
44TAF11.24251052
45PINK11.19597674
46BRD41.18193501
47DYRK21.17443466
48BCKDK1.13684838
49PLK31.11621058
50RPS6KA41.10919802
51YES11.10008086
52DYRK31.07401021
53MKNK11.07006764
54CAMK2B1.04983452
55IRAK11.03704788
56TSSK61.01344281
57TXK0.99836988
58GRK70.95836431
59PHKG10.94258524
60PHKG20.94258524
61CDK190.91947804
62PAK30.90223345
63PKN10.89079635
64PLK10.87254890
65DYRK1A0.86070271
66MINK10.85736167
67NUAK10.85607391
68CAMK2A0.85149850
69MAPKAPK50.84749882
70BRAF0.84256926
71CAMK2D0.82386710
72MUSK0.82210286
73WNK40.82107837
74RIPK40.81433640
75CDK30.80897473
76NLK0.80778180
77TTK0.78615539
78EIF2AK10.75705422
79GRK50.75180984
80WEE10.74752208
81SGK2230.74217772
82SGK4940.74217772
83UHMK10.73446239
84BRSK10.73080827
85FES0.72887389
86PRKCE0.72242491
87ROCK20.70925571
88EIF2AK20.67993033
89INSRR0.67884021
90ADRBK10.67157586
91CDC70.67004373
92CLK10.66615329
93CDK80.65075402
94NTRK20.63880919
95TNK20.63526562
96CAMKK20.63380523
97RPS6KA50.62711756
98CCNB10.62326426
99PRKCG0.60821474
100CSNK1G30.60581631
101PRKCI0.55411638
102FGR0.54041759
103SGK20.53783925
104STK30.53314137
105WNK30.50549014
106ACVR1B0.50407466
107ERBB30.49851440
108AURKA0.48685333
109ATR0.46757506
110FGFR20.46755086
111TGFBR10.46354654
112STK38L0.45103380
113CSNK1A10.44381273
114AURKB0.44329633
115CDK50.44297076
116CDK180.44167962
117CDK140.43653966
118MYLK0.43355117
119PASK0.43248614
120CAMK2G0.43234100
121LIMK10.42088599
122CDK11A0.41778880
123CDC42BPA0.40938586
124CSNK2A10.40643689
125PRKCQ0.40516967
126CSNK2A20.40506610
127ATM0.39257304
128CSNK1G20.39130042
129SIK30.38824498
130CDK150.38795120
131PRKACA0.38138293
132GRK10.37843956
133OBSCN0.37355416
134CSNK1A1L0.36254209
135CSNK1E0.35826425
136CHEK20.35819739
137FGFR10.31526875
138FER0.27125223

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.39406293
2RNA polymerase_Homo sapiens_hsa030203.05179693
3Nicotine addiction_Homo sapiens_hsa050332.83176626
4Parkinsons disease_Homo sapiens_hsa050122.65141272
5Ribosome_Homo sapiens_hsa030102.60203465
6Proteasome_Homo sapiens_hsa030502.53099534
7Protein export_Homo sapiens_hsa030602.43483830
8Phototransduction_Homo sapiens_hsa047442.27133593
9Alzheimers disease_Homo sapiens_hsa050102.20948480
10Propanoate metabolism_Homo sapiens_hsa006402.17142039
11Huntingtons disease_Homo sapiens_hsa050162.10567353
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96901678
13Butanoate metabolism_Homo sapiens_hsa006501.92776403
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85366187
15Collecting duct acid secretion_Homo sapiens_hsa049661.81682939
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79131025
17One carbon pool by folate_Homo sapiens_hsa006701.76671098
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65905493
19Serotonergic synapse_Homo sapiens_hsa047261.64021277
20Selenocompound metabolism_Homo sapiens_hsa004501.62795689
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.59482616
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57839710
23Morphine addiction_Homo sapiens_hsa050321.57328921
24Spliceosome_Homo sapiens_hsa030401.57041144
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56984561
26* Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55607790
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52347857
28Basal transcription factors_Homo sapiens_hsa030221.46663375
29GABAergic synapse_Homo sapiens_hsa047271.46342354
30Synaptic vesicle cycle_Homo sapiens_hsa047211.46002066
31Glutamatergic synapse_Homo sapiens_hsa047241.44869891
32Fanconi anemia pathway_Homo sapiens_hsa034601.43810846
33Vibrio cholerae infection_Homo sapiens_hsa051101.40386171
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36822988
35Sulfur metabolism_Homo sapiens_hsa009201.32671098
36Taste transduction_Homo sapiens_hsa047421.32454582
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30092455
38Pyrimidine metabolism_Homo sapiens_hsa002401.28535697
39Olfactory transduction_Homo sapiens_hsa047401.25905395
40Amphetamine addiction_Homo sapiens_hsa050311.25717761
41Circadian entrainment_Homo sapiens_hsa047131.23871610
42Long-term depression_Homo sapiens_hsa047301.22996985
43Cardiac muscle contraction_Homo sapiens_hsa042601.22769635
44Homologous recombination_Homo sapiens_hsa034401.21455766
45Peroxisome_Homo sapiens_hsa041461.17981651
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.17248254
47Nucleotide excision repair_Homo sapiens_hsa034201.15863039
48Autoimmune thyroid disease_Homo sapiens_hsa053201.15806781
49Ether lipid metabolism_Homo sapiens_hsa005651.15527553
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15068654
51Non-homologous end-joining_Homo sapiens_hsa034501.14243669
52Long-term potentiation_Homo sapiens_hsa047201.13158573
53Purine metabolism_Homo sapiens_hsa002301.12788661
54Nitrogen metabolism_Homo sapiens_hsa009101.06945213
55Rheumatoid arthritis_Homo sapiens_hsa053231.06764988
56Folate biosynthesis_Homo sapiens_hsa007901.05908672
57Dopaminergic synapse_Homo sapiens_hsa047281.05825284
58Mismatch repair_Homo sapiens_hsa034301.03538156
59RNA degradation_Homo sapiens_hsa030181.02648028
60Pyruvate metabolism_Homo sapiens_hsa006201.00513588
61Fatty acid metabolism_Homo sapiens_hsa012120.97988204
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97853600
63Axon guidance_Homo sapiens_hsa043600.97191989
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96833994
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96093782
66Type I diabetes mellitus_Homo sapiens_hsa049400.93777891
67Sphingolipid metabolism_Homo sapiens_hsa006000.93060047
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92930469
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89721655
70* Metabolic pathways_Homo sapiens_hsa011000.88746436
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88005518
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86621372
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83070485
74Allograft rejection_Homo sapiens_hsa053300.82130023
75Alcoholism_Homo sapiens_hsa050340.79296591
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79145189
77Graft-versus-host disease_Homo sapiens_hsa053320.78888393
78Cholinergic synapse_Homo sapiens_hsa047250.78088210
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76505893
80Glutathione metabolism_Homo sapiens_hsa004800.76242854
81Calcium signaling pathway_Homo sapiens_hsa040200.76114556
82Caffeine metabolism_Homo sapiens_hsa002320.76008827
83RNA transport_Homo sapiens_hsa030130.75680754
84Vitamin B6 metabolism_Homo sapiens_hsa007500.74570582
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72320847
86DNA replication_Homo sapiens_hsa030300.72037314
87Cocaine addiction_Homo sapiens_hsa050300.70133466
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.69795543
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69469585
90Salivary secretion_Homo sapiens_hsa049700.69264395
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68216181
92Steroid biosynthesis_Homo sapiens_hsa001000.64558831
93Chemical carcinogenesis_Homo sapiens_hsa052040.64510903
94Renin secretion_Homo sapiens_hsa049240.64214022
95Insulin secretion_Homo sapiens_hsa049110.64197824
96Arachidonic acid metabolism_Homo sapiens_hsa005900.63520617
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63387694
98Tryptophan metabolism_Homo sapiens_hsa003800.63150044
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62309680
100Oocyte meiosis_Homo sapiens_hsa041140.61626385
101beta-Alanine metabolism_Homo sapiens_hsa004100.61168567
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60946317
103Epstein-Barr virus infection_Homo sapiens_hsa051690.60560394
104Oxytocin signaling pathway_Homo sapiens_hsa049210.58469735
105p53 signaling pathway_Homo sapiens_hsa041150.57475723
106Phagosome_Homo sapiens_hsa041450.55926181
107Fatty acid degradation_Homo sapiens_hsa000710.55694266
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54814379
109Ras signaling pathway_Homo sapiens_hsa040140.53614340
110Systemic lupus erythematosus_Homo sapiens_hsa053220.51644217
111Regulation of autophagy_Homo sapiens_hsa041400.50023563
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.49829100
113Primary immunodeficiency_Homo sapiens_hsa053400.47990719
114Retinol metabolism_Homo sapiens_hsa008300.47917019
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.45121645
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45043735
117Fatty acid elongation_Homo sapiens_hsa000620.44668265
118Asthma_Homo sapiens_hsa053100.44322299
119Gap junction_Homo sapiens_hsa045400.42663309
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41364889
121Circadian rhythm_Homo sapiens_hsa047100.40852873
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40370081
123cAMP signaling pathway_Homo sapiens_hsa040240.40174872
124mRNA surveillance pathway_Homo sapiens_hsa030150.39818875
125Cell cycle_Homo sapiens_hsa041100.39610052
126Wnt signaling pathway_Homo sapiens_hsa043100.39569860
127Gastric acid secretion_Homo sapiens_hsa049710.39040603
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39031216
129Carbon metabolism_Homo sapiens_hsa012000.38896259
130Linoleic acid metabolism_Homo sapiens_hsa005910.38783977
131Hematopoietic cell lineage_Homo sapiens_hsa046400.38503825
132Melanogenesis_Homo sapiens_hsa049160.36352821
133African trypanosomiasis_Homo sapiens_hsa051430.36045609
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34850921
135Fat digestion and absorption_Homo sapiens_hsa049750.34840444
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34715067
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32789224
138Base excision repair_Homo sapiens_hsa034100.32758673
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31552801
140Hedgehog signaling pathway_Homo sapiens_hsa043400.30502721
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30047686
142T cell receptor signaling pathway_Homo sapiens_hsa046600.29734809
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29492031
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.29327876
145Arginine and proline metabolism_Homo sapiens_hsa003300.28951604
146Basal cell carcinoma_Homo sapiens_hsa052170.25234155
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23956404
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23954668
149Vitamin digestion and absorption_Homo sapiens_hsa049770.23756378

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