GGT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.63397329
2urate metabolic process (GO:0046415)9.38735090
3aminoglycoside antibiotic metabolic process (GO:0030647)8.61090613
4drug transport (GO:0015893)8.43104097
5lysine catabolic process (GO:0006554)7.95942065
6lysine metabolic process (GO:0006553)7.95942065
7organic cation transport (GO:0015695)7.76128517
8phosphate ion transport (GO:0006817)7.02681980
9drug catabolic process (GO:0042737)6.77534730
10exogenous drug catabolic process (GO:0042738)6.23387575
11quaternary ammonium group transport (GO:0015697)6.12572177
12glyoxylate metabolic process (GO:0046487)6.03561103
13phosphate ion transmembrane transport (GO:0035435)5.86805629
14aspartate family amino acid catabolic process (GO:0009068)5.73833142
15response to mercury ion (GO:0046689)5.51418725
16tricarboxylic acid metabolic process (GO:0072350)5.51226437
17branched-chain amino acid metabolic process (GO:0009081)5.50224398
18renal absorption (GO:0070293)5.46242736
19modified amino acid transport (GO:0072337)5.44590235
20excretion (GO:0007588)5.31715303
21valine metabolic process (GO:0006573)5.31174673
22short-chain fatty acid metabolic process (GO:0046459)5.17428501
23homocysteine metabolic process (GO:0050667)5.17063736
24proline metabolic process (GO:0006560)5.07719680
25toxin transport (GO:1901998)4.97675423
26vitamin D metabolic process (GO:0042359)4.79205952
27intestinal cholesterol absorption (GO:0030299)4.73168077
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.70131624
29branched-chain amino acid catabolic process (GO:0009083)4.67952554
30serine family amino acid catabolic process (GO:0009071)4.63792041
31oligosaccharide catabolic process (GO:0009313)4.63754553
32phosphate ion homeostasis (GO:0055062)4.62340057
33trivalent inorganic anion homeostasis (GO:0072506)4.62340057
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.59205640
35L-phenylalanine metabolic process (GO:0006558)4.59205640
36amino-acid betaine transport (GO:0015838)4.48334092
37carnitine transport (GO:0015879)4.48334092
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.47316693
39L-phenylalanine catabolic process (GO:0006559)4.47316693
402-oxoglutarate metabolic process (GO:0006103)4.45205717
41fructose metabolic process (GO:0006000)4.43975122
42intestinal absorption (GO:0050892)4.41871906
43NADH metabolic process (GO:0006734)4.38524879
44cobalamin metabolic process (GO:0009235)4.31376928
45metanephric tubule development (GO:0072170)4.29853042
46metanephric nephron tubule development (GO:0072234)4.29853042
47aromatic amino acid family catabolic process (GO:0009074)4.29742130
48* cysteine metabolic process (GO:0006534)4.21844172
49response to phenylpropanoid (GO:0080184)4.18031000
50amino-acid betaine metabolic process (GO:0006577)4.17162904
51plasma lipoprotein particle assembly (GO:0034377)4.15081459
52indole-containing compound catabolic process (GO:0042436)4.15050752
53indolalkylamine catabolic process (GO:0046218)4.15050752
54tryptophan catabolic process (GO:0006569)4.15050752
55glycoside metabolic process (GO:0016137)4.14717755
56fatty acid beta-oxidation (GO:0006635)4.12166962
57digestion (GO:0007586)4.08092703
58* leukotriene metabolic process (GO:0006691)4.01109923
59* nonribosomal peptide biosynthetic process (GO:0019184)4.00102254
60tryptophan metabolic process (GO:0006568)3.99821666
61* serine family amino acid metabolic process (GO:0009069)3.99085532
62beta-amyloid metabolic process (GO:0050435)3.95491121
63sulfur amino acid catabolic process (GO:0000098)3.93907427
64metanephric nephron epithelium development (GO:0072243)3.93742166
65vitamin transport (GO:0051180)3.90222346
66very-low-density lipoprotein particle assembly (GO:0034379)3.89762662
67fatty acid oxidation (GO:0019395)3.82259427
68regulation of cholesterol esterification (GO:0010872)3.81896000
69sulfur compound transport (GO:0072348)3.74779711
70lipid oxidation (GO:0034440)3.74322384
71regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.73917467
72* leukotriene biosynthetic process (GO:0019370)3.73327268
73protein-lipid complex assembly (GO:0065005)3.73171845
74carnitine metabolic process (GO:0009437)3.66805718
75acetyl-CoA metabolic process (GO:0006084)3.66572097
76phospholipid efflux (GO:0033700)3.65348529
77fatty acid catabolic process (GO:0009062)3.63069338
78flavonoid metabolic process (GO:0009812)3.60906682
79polyol transport (GO:0015791)3.59187659
80positive regulation of triglyceride lipase activity (GO:0061365)3.59030184
81positive regulation of lipoprotein lipase activity (GO:0051006)3.59030184
82metanephric epithelium development (GO:0072207)3.56318766
83angiotensin maturation (GO:0002003)3.52697554
84cellular ketone body metabolic process (GO:0046950)3.51378385
85triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.51361112
86alpha-amino acid catabolic process (GO:1901606)3.50923725
87* cellular amino acid catabolic process (GO:0009063)3.50824642
88nephron tubule development (GO:0072080)3.48646802
89* cellular modified amino acid catabolic process (GO:0042219)3.47859861
90regulation of cholesterol homeostasis (GO:2000188)3.47247812
91biotin metabolic process (GO:0006768)3.44744720
92drug metabolic process (GO:0017144)3.44014001
93modulation by symbiont of host immune response (GO:0052553)3.40733120
94positive regulation by symbiont of host defense response (GO:0052509)3.40733120
95modulation by symbiont of host defense response (GO:0052031)3.40733120
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40733120
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40733120
98positive regulation by organism of defense response of other organism involved in symbiotic interact3.40733120
99sodium-independent organic anion transport (GO:0043252)3.40686219
100* glutathione biosynthetic process (GO:0006750)3.38117072
101response to growth hormone (GO:0060416)3.36610979
102complement activation, alternative pathway (GO:0006957)3.34014221
103epoxygenase P450 pathway (GO:0019373)3.31672544
104monocarboxylic acid catabolic process (GO:0072329)3.31386224
105negative regulation of digestive system process (GO:0060457)3.29475939
106* carboxylic acid catabolic process (GO:0046395)3.27823258
107* organic acid catabolic process (GO:0016054)3.27823258
108cholesterol efflux (GO:0033344)3.27446744
109aromatic amino acid family metabolic process (GO:0009072)3.26882584
110protein retention in ER lumen (GO:0006621)3.26322054
111kynurenine metabolic process (GO:0070189)3.26227012
112pyrimidine ribonucleoside catabolic process (GO:0046133)3.25642755
113transcytosis (GO:0045056)3.25552948
114response to peptidoglycan (GO:0032494)3.25053067
115oxaloacetate metabolic process (GO:0006107)3.24243581
116alditol metabolic process (GO:0019400)3.23873441
117tricarboxylic acid cycle (GO:0006099)3.23224649
118NIK/NF-kappaB signaling (GO:0038061)3.21929232
119transepithelial transport (GO:0070633)3.21858375
120succinate metabolic process (GO:0006105)3.21047446
121low-density lipoprotein particle remodeling (GO:0034374)3.20585539
122protein-lipid complex remodeling (GO:0034368)3.18709115
123macromolecular complex remodeling (GO:0034367)3.18709115
124plasma lipoprotein particle remodeling (GO:0034369)3.18709115
125hormone catabolic process (GO:0042447)3.18410802
126high-density lipoprotein particle remodeling (GO:0034375)3.17886313
127antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17632992
128plasma lipoprotein particle organization (GO:0071827)3.15969118
129amino acid transmembrane transport (GO:0003333)3.14810204
130antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11846734
131regulation of protein activation cascade (GO:2000257)3.08445957
132antigen processing and presentation of endogenous antigen (GO:0019883)3.08431544
133glycosphingolipid catabolic process (GO:0046479)3.06583040
1344-hydroxyproline metabolic process (GO:0019471)3.06166745
135fat-soluble vitamin biosynthetic process (GO:0042362)3.05331946
136regulation of complement activation (GO:0030449)3.05274627
137negative regulation of sterol transport (GO:0032372)3.04846795
138negative regulation of cholesterol transport (GO:0032375)3.04846795
139detection of molecule of bacterial origin (GO:0032490)3.02798487
140lipoprotein metabolic process (GO:0042157)3.01670451
141regulation of triglyceride catabolic process (GO:0010896)2.99252757
142protein-lipid complex subunit organization (GO:0071825)2.99116137
143acute-phase response (GO:0006953)2.95646384
144glycolipid catabolic process (GO:0019377)2.93347639
145positive regulation of fatty acid biosynthetic process (GO:0045723)2.90942546
146glucose 6-phosphate metabolic process (GO:0051156)2.90228195
147negative regulation of fibrinolysis (GO:0051918)2.89837314
148urea metabolic process (GO:0019627)2.88640730
149macrophage activation involved in immune response (GO:0002281)2.85762890
150mannose metabolic process (GO:0006013)2.84913562
151urea cycle (GO:0000050)2.84609420
152peptidyl-glutamic acid carboxylation (GO:0017187)2.82047883
153protein carboxylation (GO:0018214)2.82047883
154regulation of interferon-beta biosynthetic process (GO:0045357)2.77899531
155reverse cholesterol transport (GO:0043691)2.77291801
156positive regulation of Cdc42 GTPase activity (GO:0043089)2.76897805
157detection of external biotic stimulus (GO:0098581)2.74759625
158nitrogen cycle metabolic process (GO:0071941)2.73008320
159diacylglycerol metabolic process (GO:0046339)2.69154117
160pinocytosis (GO:0006907)2.67830620
161proline biosynthetic process (GO:0006561)2.64338152
162lipopolysaccharide-mediated signaling pathway (GO:0031663)2.64253042
163neutrophil activation involved in immune response (GO:0002283)2.63401729
164detection of other organism (GO:0098543)2.62066243
165detection of bacterium (GO:0016045)2.61072832
166regulation of superoxide anion generation (GO:0032928)2.59772600
167* peptide catabolic process (GO:0043171)2.59262523
168positive regulation of lipid catabolic process (GO:0050996)2.53915326
169regulation of apoptotic cell clearance (GO:2000425)2.53883756
170GDP-mannose metabolic process (GO:0019673)2.52214766
171regulation of bile acid biosynthetic process (GO:0070857)2.52154739
172myeloid dendritic cell differentiation (GO:0043011)2.52091586
173plasma lipoprotein particle clearance (GO:0034381)2.51902238
174complement activation, classical pathway (GO:0006958)2.51772487
175ceramide catabolic process (GO:0046514)2.48747984
176regulation of fibrinolysis (GO:0051917)2.47869201
177immunoglobulin mediated immune response (GO:0016064)2.46535595
178cholesterol homeostasis (GO:0042632)2.46377897
179regulation of apoptotic process involved in morphogenesis (GO:1902337)2.46096500
180* glutathione metabolic process (GO:0006749)2.44744952
181negative regulation of cell killing (GO:0031342)2.43763011
182negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.43763011
183alpha-linolenic acid metabolic process (GO:0036109)2.43546470
184sterol homeostasis (GO:0055092)2.43399962
185positive regulation of extracellular matrix organization (GO:1903055)2.42761107
186positive regulation of cellular amine metabolic process (GO:0033240)2.42103653
187detection of biotic stimulus (GO:0009595)2.40242534
188regulation of extracellular matrix organization (GO:1903053)2.39648193
189T-helper 1 type immune response (GO:0042088)2.38000474
190regulation of vitamin metabolic process (GO:0030656)2.36976928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.16254320
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.88503977
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.51209809
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.92639782
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.77444559
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.42543113
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.41452091
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.18169362
9CDX2_20551321_ChIP-Seq_CACO-2_Human3.08067126
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.72495881
11VDR_21846776_ChIP-Seq_THP-1_Human2.68751609
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61984619
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.59395959
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.59032805
15* GATA4_25053715_ChIP-Seq_YYC3_Human2.40204177
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.28057013
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27453315
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.19818909
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.19475887
20AR_21909140_ChIP-Seq_LNCAP_Human2.17765688
21GATA6_25053715_ChIP-Seq_YYC3_Human2.12165358
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.05807457
23MYC_22102868_ChIP-Seq_BL_Human2.05405880
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.04762546
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04369924
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.03575120
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03274093
28VDR_24763502_ChIP-Seq_THP-1_Human2.02300492
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01958099
30CLOCK_20551151_ChIP-Seq_293T_Human2.00584317
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98324180
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.90411732
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89539447
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89134656
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85777647
36* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.84755415
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.82964846
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78934652
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71980323
40TCF7_22412390_ChIP-Seq_EML_Mouse1.70667526
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.68223789
42RACK7_27058665_Chip-Seq_MCF-7_Human1.66751494
43* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66447727
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66323735
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66085119
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.63965991
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61641577
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59185773
49TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59113966
50LXR_22292898_ChIP-Seq_THP-1_Human1.58218765
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56988494
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56697003
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.56539424
54MAF_26560356_Chip-Seq_TH1_Human1.55090934
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54956028
56SOX2_20726797_ChIP-Seq_SW620_Human1.51380321
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.46617887
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.45362807
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44542398
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42626723
61* FOXA2_19822575_ChIP-Seq_HepG2_Human1.41457982
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38661359
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38261014
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36106117
65SPI1_23127762_ChIP-Seq_K562_Human1.33320451
66* UTX_26944678_Chip-Seq_JUKART_Human1.32308617
67KDM2B_26808549_Chip-Seq_DND41_Human1.31277441
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30360187
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29318381
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28705206
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.28356646
72EGR1_19032775_ChIP-ChIP_M12_Human1.27656524
73BCL6_27268052_Chip-Seq_Bcells_Human1.26238201
74* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25128558
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23871418
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23077841
77MAF_26560356_Chip-Seq_TH2_Human1.22502581
78* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21877697
79* SPI1_23547873_ChIP-Seq_NB4_Human1.21687067
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.21411505
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21142986
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20947971
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20411230
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19476254
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19288992
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18174074
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.17725162
88MYB_26560356_Chip-Seq_TH1_Human1.17697007
89ATF3_27146783_Chip-Seq_COLON_Human1.17409697
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17161445
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17026244
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16655833
93SCL_19346495_ChIP-Seq_HPC-7_Human1.15955811
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13923424
95NCOR1_26117541_ChIP-Seq_K562_Human1.12702349
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11947519
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.11497339
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11360537
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11113640
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10329404
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08741252
102GATA1_19941826_ChIP-Seq_K562_Human1.08144133
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06339408
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.06254334
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05884810
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05734009
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05637640
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04843233
109CREB1_26743006_Chip-Seq_LNCaP_Human1.04528460
110* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03794451
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03698116
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03178267
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.02086312
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01999009
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01311120
116MYB_26560356_Chip-Seq_TH2_Human1.00920355
117* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00384972
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00346847
119* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99147469
120* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99084158
121P68_20966046_ChIP-Seq_HELA_Human0.98588356
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.95040160
123TBX20_22080862_ChIP-Seq_HEART_Mouse0.95040160
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94722931
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94309843
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94300223
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93801452
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93110846
129VDR_22108803_ChIP-Seq_LS180_Human0.92351124
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91192047
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90295783
132* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88816523
133MYC_19915707_ChIP-ChIP_AK7_Human0.87333021
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87142889
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.87092326
136GATA2_19941826_ChIP-Seq_K562_Human0.86313922
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84837964
138GATA3_24758297_ChIP-Seq_MCF-7_Human0.83338337
139SMC4_20622854_ChIP-Seq_HELA_Human0.83276129
140* TP63_22573176_ChIP-Seq_HFKS_Human0.82891807
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82647268
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81800306
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.81562883
144CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81426933
145* TAF2_19829295_ChIP-Seq_ESCs_Human0.79735728
146SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79627006
147* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.78948265
148CEBPB_22108803_ChIP-Seq_LS180_Human0.78749909
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77568614
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.77317327
151ZNF263_19887448_ChIP-Seq_K562_Human0.77162078
152P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76634337
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76143681
154CDX2_22108803_ChIP-Seq_LS180_Human0.75688664
155SA1_27219007_Chip-Seq_ERYTHROID_Human0.75102146
156RAC3_21632823_ChIP-Seq_H3396_Human0.74974726
157RXR_22108803_ChIP-Seq_LS180_Human0.72420316
158* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72047720
159BCOR_27268052_Chip-Seq_Bcells_Human0.70510666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.37273504
2MP0004043_abnormal_pH_regulation5.33081743
3MP0002139_abnormal_hepatobiliary_system4.89915232
4MP0004019_abnormal_vitamin_homeostasis4.52343088
5* MP0005332_abnormal_amino_acid4.24349228
6MP0001666_abnormal_nutrient_absorption4.01419033
7MP0009643_abnormal_urine_homeostasis3.62546962
8MP0005365_abnormal_bile_salt3.34797857
9MP0001765_abnormal_ion_homeostasis3.27054660
10MP0002138_abnormal_hepatobiliary_system3.17774548
11MP0003195_calcinosis2.96247632
12MP0005085_abnormal_gallbladder_physiolo2.89908320
13MP0008875_abnormal_xenobiotic_pharmacok2.86830907
14MP0005377_hearing/vestibular/ear_phenot2.86135013
15MP0003878_abnormal_ear_physiology2.86135013
16MP0003436_decreased_susceptibility_to2.81049882
17MP0005636_abnormal_mineral_homeostasis2.76242416
18MP0001756_abnormal_urination2.69354146
19MP0003252_abnormal_bile_duct2.56691256
20MP0003303_peritoneal_inflammation2.56539362
21MP0002136_abnormal_kidney_physiology2.53164463
22MP0005084_abnormal_gallbladder_morpholo2.49368795
23MP0000685_abnormal_immune_system2.13710460
24MP0009785_altered_susceptibility_to2.04257274
25MP0005058_abnormal_lysosome_morphology2.01186078
26MP0001835_abnormal_antigen_presentation2.01053519
27MP0010155_abnormal_intestine_physiology1.96719598
28MP0004264_abnormal_extraembryonic_tissu1.95071394
29MP0001958_emphysema1.93933778
30MP0005025_abnormal_response_to1.88426826
31MP0002419_abnormal_innate_immunity1.83975374
32MP0003724_increased_susceptibility_to1.83289896
33MP0001790_abnormal_immune_system1.80725859
34MP0005387_immune_system_phenotype1.80725859
35MP0005083_abnormal_biliary_tract1.77882074
36MP0009333_abnormal_splenocyte_physiolog1.74359991
37MP0005220_abnormal_exocrine_pancreas1.74152211
38MP0002148_abnormal_hypersensitivity_rea1.74022265
39MP0000538_abnormal_urinary_bladder1.73912493
40MP0010234_abnormal_vibrissa_follicle1.72394894
41MP0006082_CNS_inflammation1.64453329
42MP0008260_abnormal_autophagy1.63645666
43MP0000858_altered_metastatic_potential1.62771584
44MP0004947_skin_inflammation1.61913646
45MP0005000_abnormal_immune_tolerance1.60129135
46MP0005464_abnormal_platelet_physiology1.58388013
47MP0001800_abnormal_humoral_immune1.56856630
48MP0003806_abnormal_nucleotide_metabolis1.54754775
49MP0005451_abnormal_body_composition1.54121175
50MP0005671_abnormal_response_to1.53874313
51MP0002723_abnormal_immune_serum1.48389126
52MP0003186_abnormal_redox_activity1.45749209
53MP0002452_abnormal_antigen_presenting1.43840541
54MP0005584_abnormal_enzyme/coenzyme_acti1.41387090
55MP0008961_abnormal_basal_metabolism1.41240919
56MP0005319_abnormal_enzyme/_coenzyme1.38976646
57MP0002876_abnormal_thyroid_physiology1.32970358
58MP0002132_abnormal_respiratory_system1.30677075
59MP0004147_increased_porphyrin_level1.29959935
60MP0001819_abnormal_immune_cell1.29791804
61MP0002420_abnormal_adaptive_immunity1.29063095
62MP0003300_gastrointestinal_ulcer1.27958496
63MP0001533_abnormal_skeleton_physiology1.27011927
64MP0004885_abnormal_endolymph1.24870229
65MP0005310_abnormal_salivary_gland1.22800393
66MP0010329_abnormal_lipoprotein_level1.17907983
67MP0002166_altered_tumor_susceptibility1.17560086
68MP0002118_abnormal_lipid_homeostasis1.16823663
69MP0001764_abnormal_homeostasis1.15644745
70MP0003191_abnormal_cellular_cholesterol1.12734008
71MP0002405_respiratory_system_inflammati1.11631074
72MP0003656_abnormal_erythrocyte_physiolo1.10955661
73MP0005076_abnormal_cell_differentiation1.09926639
74MP0003453_abnormal_keratinocyte_physiol1.08401657
75MP0006036_abnormal_mitochondrial_physio1.07933941
76MP0003075_altered_response_to1.07428348
77MP0003638_abnormal_response/metabolism_1.06511705
78MP0002998_abnormal_bone_remodeling1.06169298
79MP0001664_abnormal_digestion1.04929810
80* MP0000716_abnormal_immune_system1.03953867
81MP0005166_decreased_susceptibility_to1.02591727
82MP0009278_abnormal_bone_marrow1.02300850
83MP0002796_impaired_skin_barrier1.01402229
84MP0003763_abnormal_thymus_physiology1.01156509
85MP0000604_amyloidosis1.01014246
86MP0000230_abnormal_systemic_arterial0.97809163
87MP0002135_abnormal_kidney_morphology0.96404328
88MP0005535_abnormal_body_temperature0.93472393
89MP0002398_abnormal_bone_marrow0.91752131
90MP0005666_abnormal_adipose_tissue0.91296368
91MP0002928_abnormal_bile_duct0.88969890
92MP0003183_abnormal_peptide_metabolism0.87646958
93MP0002933_joint_inflammation0.87616700
94MP0002254_reproductive_system_inflammat0.87577811
95MP0009840_abnormal_foam_cell0.86957097
96* MP0002429_abnormal_blood_cell0.86746395
97MP0005670_abnormal_white_adipose0.85900195
98MP0003959_abnormal_lean_body0.85703743
99MP0002168_other_aberrant_phenotype0.85381021
100MP0003705_abnormal_hypodermis_morpholog0.85202254
101MP0002396_abnormal_hematopoietic_system0.83723884
102MP0001853_heart_inflammation0.83041226
103MP0002896_abnormal_bone_mineralization0.81691225
104MP0000609_abnormal_liver_physiology0.81198744
105MP0002722_abnormal_immune_system0.80590578
106MP0003283_abnormal_digestive_organ0.80232003
107* MP0000689_abnormal_spleen_morphology0.79544550
108MP0000249_abnormal_blood_vessel0.79424309
109MP0003868_abnormal_feces_composition0.78960565
110MP0001849_ear_inflammation0.77323920
111MP0001663_abnormal_digestive_system0.76665856
112MP0004510_myositis0.75766829
113* MP0009642_abnormal_blood_homeostasis0.75636494
114MP0009763_increased_sensitivity_to0.74589358
115MP0002006_tumorigenesis0.73207470
116MP0002098_abnormal_vibrissa_morphology0.67243798
117MP0005501_abnormal_skin_physiology0.64416816
118MP0005381_digestive/alimentary_phenotyp0.63682399
119MP0000598_abnormal_liver_morphology0.61332806
120MP0005408_hypopigmentation0.60540048
121MP0001873_stomach_inflammation0.60344671
122MP0005395_other_phenotype0.59962251
123MP0008469_abnormal_protein_level0.57686133
124MP0003172_abnormal_lysosome_physiology0.55119613
125MP0003866_abnormal_defecation0.54898286
126MP0005165_increased_susceptibility_to0.54299062
127MP0009764_decreased_sensitivity_to0.54296438
128MP0001661_extended_life_span0.52902805
129* MP0002078_abnormal_glucose_homeostasis0.50298908
130MP0003315_abnormal_perineum_morphology0.50266573
131MP0003879_abnormal_hair_cell0.48805704
132* MP0003953_abnormal_hormone_level0.47227216
133MP0001485_abnormal_pinna_reflex0.47222121
134MP0000747_muscle_weakness0.46411651
135MP0005375_adipose_tissue_phenotype0.46176585
136MP0009765_abnormal_xenobiotic_induced0.45902286
137MP0004233_abnormal_muscle_weight0.44377205
138MP0003329_amyloid_beta_deposits0.42402912
139MP0006035_abnormal_mitochondrial_morpho0.41026664
140MP0003646_muscle_fatigue0.40262271
141MP0001944_abnormal_pancreas_morphology0.39769417
142MP0000377_abnormal_hair_follicle0.39293774
143MP0000537_abnormal_urethra_morphology0.37240173
144MP0001845_abnormal_inflammatory_respons0.37173597
145MP0005448_abnormal_energy_balance0.36688307
146MP0002069_abnormal_eating/drinking_beha0.35682123
147MP0010386_abnormal_urinary_bladder0.35569022
148MP0000534_abnormal_ureter_morphology0.35446957
149* MP0003795_abnormal_bone_structure0.34738842
150MP0000490_abnormal_crypts_of0.34366132
151MP0000462_abnormal_digestive_system0.33625362
152MP0000477_abnormal_intestine_morphology0.33239791
153MP0000678_abnormal_parathyroid_gland0.32769783

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)6.91775042
2Increased circulating renin level (HP:0000848)6.76427334
3Metabolic alkalosis (HP:0200114)6.53222375
4Hypokalemic alkalosis (HP:0001949)6.34144285
5Hyperactive renin-angiotensin system (HP:0000841)6.18863936
6Hypomagnesemia (HP:0002917)6.15193153
7Polyuria (HP:0000103)5.82739415
8Abnormal urine output (HP:0012590)5.73384870
9Abnormality of chloride homeostasis (HP:0011422)5.72077297
10Abnormality of renal excretion (HP:0011036)5.65547570
11Proximal tubulopathy (HP:0000114)5.47092850
12Abnormality of magnesium homeostasis (HP:0004921)5.36553975
13Abnormality of glutamine family amino acid metabolism (HP:0010902)5.22338267
14Hyperglycinuria (HP:0003108)5.21235317
15Hyperuricemia (HP:0002149)5.02228907
16Increased purine levels (HP:0004368)5.02228907
17Polydipsia (HP:0001959)4.68149018
18Abnormal drinking behavior (HP:0030082)4.68149018
19Abnormality of purine metabolism (HP:0004352)4.68004650
20Deep venous thrombosis (HP:0002625)4.41547864
21Systemic lupus erythematosus (HP:0002725)4.36798445
22Renal salt wasting (HP:0000127)4.35305748
23Abnormality of glycine metabolism (HP:0010895)4.26149728
24Abnormality of serine family amino acid metabolism (HP:0010894)4.26149728
25Tetany (HP:0001281)4.19237010
26Abnormality of renin-angiotensin system (HP:0000847)4.19178233
27Alkalosis (HP:0001948)4.19066444
28Hyperaldosteronism (HP:0000859)4.10367112
29Generalized aminoaciduria (HP:0002909)4.06972697
30Abnormality of urine glucose concentration (HP:0011016)3.86098616
31Glycosuria (HP:0003076)3.86098616
32Ketoacidosis (HP:0001993)3.81160885
33Hypercalciuria (HP:0002150)3.76875386
34Eczematoid dermatitis (HP:0000976)3.67234453
35Complement deficiency (HP:0004431)3.60487704
36Abnormality of glycolipid metabolism (HP:0010969)3.50122879
37Abnormality of liposaccharide metabolism (HP:0010968)3.50122879
38Abnormality of glycosphingolipid metabolism (HP:0004343)3.50122879
39Abnormality of proline metabolism (HP:0010907)3.47875567
40Hydroxyprolinuria (HP:0003080)3.47875567
41Abnormality of macrophages (HP:0004311)3.47192681
42Dysostosis multiplex (HP:0000943)3.46440852
43Abnormality of nucleobase metabolism (HP:0010932)3.42703409
44Ketosis (HP:0001946)3.39694692
45Glomerulonephritis (HP:0000099)3.36063247
46Abnormality of monocarboxylic acid metabolism (HP:0010996)3.32285830
47Hypobetalipoproteinemia (HP:0003563)3.31015759
48Hemorrhage of the eye (HP:0011885)3.29254149
49Abnormality of complement system (HP:0005339)3.23845194
50Renal tubular acidosis (HP:0001947)3.23659816
51Hypokalemia (HP:0002900)3.23632947
52Hyperphosphaturia (HP:0003109)3.22899707
53Xanthomatosis (HP:0000991)3.22470746
54Recurrent gram-negative bacterial infections (HP:0005420)3.11498497
55Abnormality of aspartate family amino acid metabolism (HP:0010899)3.07178193
56Malnutrition (HP:0004395)3.05107082
57Abnormal urine phosphate concentration (HP:0012599)3.00277553
58Delayed epiphyseal ossification (HP:0002663)2.95662245
59Nephrolithiasis (HP:0000787)2.94852057
60Vacuolated lymphocytes (HP:0001922)2.94311747
61Flat acetabular roof (HP:0003180)2.92969910
62Abnormality of fatty-acid metabolism (HP:0004359)2.92892200
63Urinary glycosaminoglycan excretion (HP:0003541)2.92614055
64Mucopolysacchariduria (HP:0008155)2.92614055
65Joint hemorrhage (HP:0005261)2.90279962
66Widely patent fontanelles and sutures (HP:0004492)2.86143698
67Hyperglycinemia (HP:0002154)2.85159283
68Abnormality of polysaccharide metabolism (HP:0011012)2.83144049
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83144049
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83144049
71Recurrent abscess formation (HP:0002722)2.81088933
72Increased cerebral lipofuscin (HP:0011813)2.77850169
73Vascular calcification (HP:0004934)2.76345209
74Purpura (HP:0000979)2.73022907
75Orchitis (HP:0100796)2.72644838
76Dehydration (HP:0001944)2.71402196
77Nephrocalcinosis (HP:0000121)2.69758336
78Prolonged partial thromboplastin time (HP:0003645)2.67194707
79Hypophosphatemia (HP:0002148)2.67116834
80Abnormality of potassium homeostasis (HP:0011042)2.66843081
81Abnormality of sulfur amino acid metabolism (HP:0004339)2.65202683
82Myositis (HP:0100614)2.61893197
83Delayed CNS myelination (HP:0002188)2.61466398
84Increased neuronal autofluorescent lipopigment (HP:0002074)2.60473541
85Recurrent bacterial skin infections (HP:0005406)2.60285910
86Hyperammonemia (HP:0001987)2.59138766
87Loss of speech (HP:0002371)2.55365453
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52586338
89Dicarboxylic aciduria (HP:0003215)2.52586338
90Metabolic acidosis (HP:0001942)2.52067215
91Metaphyseal cupping (HP:0003021)2.49072084
92Increased serum ferritin (HP:0003281)2.48165720
93Facial shape deformation (HP:0011334)2.47761510
94Potter facies (HP:0002009)2.47761510
95Nephritis (HP:0000123)2.47342691
96Mediastinal lymphadenopathy (HP:0100721)2.45897147
97Cardiovascular calcification (HP:0011915)2.44834837
98Rickets (HP:0002748)2.43102397
99Abnormal tarsal ossification (HP:0008369)2.42566410
100Gingival bleeding (HP:0000225)2.41891464
101Chronic obstructive pulmonary disease (HP:0006510)2.41772726
102Obstructive lung disease (HP:0006536)2.41772726
103Amyloidosis (HP:0011034)2.37375461
104Vomiting (HP:0002013)2.33745469
105Abnormality of the common coagulation pathway (HP:0010990)2.32745241
106Optic neuritis (HP:0100653)2.29584507
107Retrobulbar optic neuritis (HP:0100654)2.29584507
108Myocardial infarction (HP:0001658)2.28934489
109J-shaped sella turcica (HP:0002680)2.28622892
110Confusion (HP:0001289)2.28371551
111Methylmalonic aciduria (HP:0012120)2.24841272
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17439497
113Abnormality of aromatic amino acid family metabolism (HP:0004338)2.17088365
114Hyponatremia (HP:0002902)2.15956022
115Abnormal enzyme/coenzyme activity (HP:0012379)2.15664992
116Lethargy (HP:0001254)2.15278449
117Abnormality of sodium homeostasis (HP:0010931)2.15250234
118Gingivitis (HP:0000230)2.15073939
119Vasculitis (HP:0002633)2.13538721
120Thin bony cortex (HP:0002753)2.12935448
121Abnormality of the lumbar spine (HP:0100712)2.11985076
122Pustule (HP:0200039)2.11479094
123Abnormality of alkaline phosphatase activity (HP:0004379)2.10646727
124Gastrointestinal infarctions (HP:0005244)2.08991089
125Abnormality of renal resorption (HP:0011038)2.07610937
126Ileus (HP:0002595)2.03991693
127Conjugated hyperbilirubinemia (HP:0002908)2.03377598
128Abdominal distention (HP:0003270)2.03288689
129Colitis (HP:0002583)2.03033147
130Prolonged neonatal jaundice (HP:0006579)2.02125338
131Epistaxis (HP:0000421)2.01808354
132Steatorrhea (HP:0002570)2.01787442
133Pathologic fracture (HP:0002756)2.01655747
134Nausea (HP:0002018)2.00260101
135Elevated alkaline phosphatase (HP:0003155)1.99997461
136Menorrhagia (HP:0000132)1.98979242
137Abnormality of iron homeostasis (HP:0011031)1.98447297
138Nuclear cataract (HP:0100018)1.97383721
139Tubulointerstitial fibrosis (HP:0005576)1.97221922
140Meningitis (HP:0001287)1.97131666
141Axonal loss (HP:0003447)1.96572537
142Protuberant abdomen (HP:0001538)1.95533017
143Chronic diarrhea (HP:0002028)1.94747497
144Fat malabsorption (HP:0002630)1.94409277
145Enlarged kidneys (HP:0000105)1.94310124
146Abnormality of the costochondral junction (HP:0000919)1.94156873
147Hypolipoproteinemia (HP:0010981)1.93508805
148Abnormality of the vitamin B12 metabolism (HP:0004341)1.92218226
149Recurrent fungal infections (HP:0002841)1.92043132
150Renal tubular dysfunction (HP:0000124)1.91661798
151Petechiae (HP:0000967)1.89124928
152Tubular atrophy (HP:0000092)1.86830740
153Cholecystitis (HP:0001082)1.86279159
154Abnormal gallbladder physiology (HP:0012438)1.86279159
155Adrenal overactivity (HP:0002717)1.85927879
156Pulmonary infiltrates (HP:0002113)1.84150025
157Encephalitis (HP:0002383)1.82225391
158Hypotension (HP:0002615)1.81855833
159Sensorimotor neuropathy (HP:0007141)1.81149556
160Joint swelling (HP:0001386)1.81099759
161Gastrointestinal inflammation (HP:0004386)1.79986822
162Focal segmental glomerulosclerosis (HP:0000097)1.79802878
163Wide cranial sutures (HP:0010537)1.79615464
164Glomerulosclerosis (HP:0000096)1.79440463
165Hypercholesterolemia (HP:0003124)1.79403451
166Hepatocellular carcinoma (HP:0001402)1.78823374
167Bone pain (HP:0002653)1.78047729
168Abnormality of vitamin B metabolism (HP:0004340)1.76843410
169Abnormality of pyrimidine metabolism (HP:0004353)1.76260544
170Thrombophlebitis (HP:0004418)1.75981816
171Pancreatitis (HP:0001733)1.75592163
172Recurrent skin infections (HP:0001581)1.75328868
173Thoracic kyphosis (HP:0002942)1.75242900
174Abnormal platelet function (HP:0011869)1.74460444
175Impaired platelet aggregation (HP:0003540)1.74460444
176Irritability (HP:0000737)1.74039068
177Metaphyseal irregularity (HP:0003025)1.73479255
178Bilateral sensorineural hearing impairment (HP:0008619)1.72259177
179Late onset (HP:0003584)1.69834038
180Chondrocalcinosis (HP:0000934)1.69758310
181Bicornuate uterus (HP:0000813)1.69376494
182Lymphangioma (HP:0100764)1.68153928
183Abnormality of serum amino acid levels (HP:0003112)1.65544034
184Megaloblastic anemia (HP:0001889)1.65229691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.08046963
2WNK36.96562082
3OXSR16.48101762
4BCKDK4.69742927
5STK394.07541903
6RIPK42.58462878
7STK38L2.38958622
8MST42.37153146
9PRPF4B2.35796625
10TYK22.14285319
11TBK12.12221545
12PDK32.00023945
13PDK42.00023945
14PDK21.95036908
15NEK11.91792056
16IRAK41.91127129
17SMG11.89820426
18ICK1.87319269
19FRK1.84874459
20BLK1.80003440
21MST1R1.78951169
22ERN11.78885640
23IKBKE1.57703299
24WNK11.55202415
25GRK61.50194618
26MAP3K11.46892385
27TAOK21.45866730
28MATK1.42750077
29SGK4941.41971184
30SGK2231.41971184
31CSF1R1.36565394
32FGR1.24753126
33AKT31.20895645
34IKBKB1.19687384
35FGFR31.19442039
36LRRK21.17829901
37STK381.17592512
38ACVR1B1.16370995
39TESK21.14589590
40MAP2K21.12709989
41NME11.12542852
42TNK21.08955238
43MAP3K131.08587851
44CDK121.02564394
45CDC42BPA0.98942238
46PTK60.98577108
47TRIB30.97046333
48JAK30.91577154
49FGFR40.89185923
50EPHB10.88433327
51MAP3K60.86181004
52BTK0.79410212
53MAP3K30.78588712
54JAK10.78278451
55IRAK10.77315002
56PRKCI0.76926653
57PIM20.76101275
58PINK10.75062815
59SYK0.75018802
60PTK20.72284941
61MAP3K70.71230770
62LYN0.71228143
63FES0.71052688
64IRAK30.70971291
65CHUK0.69888372
66SIK30.69536348
67HCK0.69187424
68STK100.69047786
69LATS10.68553293
70SGK30.68158120
71GSK3A0.67450105
72STK240.64139244
73DYRK1B0.62766981
74MAP3K20.61315559
75EPHA20.61264184
76LMTK20.60900320
77LCK0.59109856
78RIPK10.58917166
79PDPK10.58381992
80MET0.58373257
81MAP3K50.57204643
82NME20.56045998
83TESK10.55681558
84SGK20.55354238
85SIK20.54772799
86PAK40.54199739
87MAPK110.53966660
88HIPK20.53568366
89RPS6KL10.52750957
90RPS6KC10.52750957
91PRKAA10.51531073
92MYLK0.51076786
93FER0.51015053
94RET0.50561109
95MAPKAPK20.49912020
96INSRR0.47975284
97TTN0.46555866
98EPHA30.46535972
99PRKAA20.44964747
100YES10.44675628
101SCYL20.44259509
102ITK0.43215215
103RPS6KA20.41001683
104RPS6KA60.40851840
105TXK0.40758638
106KSR20.39334202
107EIF2AK30.39269372
108PDK10.38576106
109SGK10.36342266
110PKN20.35362478
111PRKG20.33454809
112TAOK30.32066393
113PRKCZ0.31018659
114MAPKAPK30.30905569
115BMX0.29956094
116ABL20.29898391
117EEF2K0.29887924
118TAOK10.26811324
119MAP3K110.26702196
120MAP2K10.26521344
121PAK30.25903672
122TGFBR20.25763661
123MAP3K80.25386427
124MAP2K60.22713120
125PRKCD0.19756873
126IRAK20.19703221
127TIE10.18980671
128AKT20.18378786
129PIK3CG0.17339139
130MTOR0.17126211
131PAK20.16568627
132PIM10.16377515
133MAP3K100.16273919
134STK110.15650601
135ZAP700.15465547
136PRKD20.14026071
137JAK20.14008238
138PRKACG0.13619181
139PRKCA0.13560461
140MAPK120.11530813
141MAP2K30.10191226
142CSK0.07170265
143MAPK150.06694340
144SIK10.05785467
145TTK0.04854279
146DDR20.04566931
147MAP3K140.04566746
148CSNK1A10.04519128
149MAP4K10.03343791
150INSR0.03305000
151PRKACA0.03280550
152NTRK10.03150629

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.37844749
2Butanoate metabolism_Homo sapiens_hsa006503.18038324
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15248266
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.08577927
5Vitamin digestion and absorption_Homo sapiens_hsa049773.08486790
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.98465187
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.93998101
8Propanoate metabolism_Homo sapiens_hsa006402.92261219
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.88343554
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.58387998
11Protein digestion and absorption_Homo sapiens_hsa049742.48345602
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47602786
13Complement and coagulation cascades_Homo sapiens_hsa046102.45859155
14Staphylococcus aureus infection_Homo sapiens_hsa051502.45236762
15Pyruvate metabolism_Homo sapiens_hsa006202.30403946
16Fatty acid degradation_Homo sapiens_hsa000712.21975474
17Peroxisome_Homo sapiens_hsa041462.21882624
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19718521
19Tryptophan metabolism_Homo sapiens_hsa003802.15321149
20Fat digestion and absorption_Homo sapiens_hsa049752.14978015
21Sulfur metabolism_Homo sapiens_hsa009202.05210407
22Renin-angiotensin system_Homo sapiens_hsa046141.92869214
23Mineral absorption_Homo sapiens_hsa049781.90090369
24Folate biosynthesis_Homo sapiens_hsa007901.86599591
25beta-Alanine metabolism_Homo sapiens_hsa004101.83912939
26Bile secretion_Homo sapiens_hsa049761.76834414
27Arginine and proline metabolism_Homo sapiens_hsa003301.68232583
28Carbon metabolism_Homo sapiens_hsa012001.65303426
29Starch and sucrose metabolism_Homo sapiens_hsa005001.61181175
30Leishmaniasis_Homo sapiens_hsa051401.59543198
31Collecting duct acid secretion_Homo sapiens_hsa049661.58359453
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55689397
33Fatty acid metabolism_Homo sapiens_hsa012121.55354376
34Glycerolipid metabolism_Homo sapiens_hsa005611.54603415
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.44405815
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44395005
37Osteoclast differentiation_Homo sapiens_hsa043801.43998468
38Other glycan degradation_Homo sapiens_hsa005111.39327401
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37308595
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34240993
41Arginine biosynthesis_Homo sapiens_hsa002201.34160922
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.33789100
43* Glutathione metabolism_Homo sapiens_hsa004801.32230738
44Fructose and mannose metabolism_Homo sapiens_hsa000511.31889323
45Pancreatic secretion_Homo sapiens_hsa049721.31755002
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.27555935
47PPAR signaling pathway_Homo sapiens_hsa033201.26906335
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23166625
49Histidine metabolism_Homo sapiens_hsa003401.20129716
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20111968
51Allograft rejection_Homo sapiens_hsa053301.19665231
52Selenocompound metabolism_Homo sapiens_hsa004501.18790530
53Biosynthesis of amino acids_Homo sapiens_hsa012301.16163105
54B cell receptor signaling pathway_Homo sapiens_hsa046621.13664281
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13625384
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13226260
57TNF signaling pathway_Homo sapiens_hsa046681.12898562
58Pertussis_Homo sapiens_hsa051331.12360509
59Lysine degradation_Homo sapiens_hsa003101.11744337
60Nitrogen metabolism_Homo sapiens_hsa009101.11233361
61Graft-versus-host disease_Homo sapiens_hsa053321.10233259
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09073384
63Tuberculosis_Homo sapiens_hsa051521.07550876
64Autoimmune thyroid disease_Homo sapiens_hsa053201.05304060
65Influenza A_Homo sapiens_hsa051641.00317465
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98266154
67Asthma_Homo sapiens_hsa053100.90012145
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.89949815
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88085114
70Toxoplasmosis_Homo sapiens_hsa051450.86795385
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84214294
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.80990511
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79255447
74Fatty acid biosynthesis_Homo sapiens_hsa000610.79181857
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78071425
76Prion diseases_Homo sapiens_hsa050200.77716307
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77684589
78Galactose metabolism_Homo sapiens_hsa000520.76979702
79Acute myeloid leukemia_Homo sapiens_hsa052210.76810351
80Legionellosis_Homo sapiens_hsa051340.76715097
81Pentose phosphate pathway_Homo sapiens_hsa000300.76401770
82Rheumatoid arthritis_Homo sapiens_hsa053230.74718662
83Antigen processing and presentation_Homo sapiens_hsa046120.73630477
84African trypanosomiasis_Homo sapiens_hsa051430.72237294
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69737489
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.68143929
87Herpes simplex infection_Homo sapiens_hsa051680.67616438
88Primary immunodeficiency_Homo sapiens_hsa053400.65390189
89Phenylalanine metabolism_Homo sapiens_hsa003600.63367793
90Hematopoietic cell lineage_Homo sapiens_hsa046400.62002498
91Lysosome_Homo sapiens_hsa041420.61723415
92Type I diabetes mellitus_Homo sapiens_hsa049400.60536552
93* Metabolic pathways_Homo sapiens_hsa011000.59558358
94Thyroid hormone synthesis_Homo sapiens_hsa049180.58001619
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.57591002
96Chemical carcinogenesis_Homo sapiens_hsa052040.55682738
97Oxidative phosphorylation_Homo sapiens_hsa001900.55317930
98Bladder cancer_Homo sapiens_hsa052190.53755480
99Malaria_Homo sapiens_hsa051440.52744518
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52673016
101Measles_Homo sapiens_hsa051620.52259724
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52165167
103Steroid biosynthesis_Homo sapiens_hsa001000.51821435
104Apoptosis_Homo sapiens_hsa042100.51487914
105Salmonella infection_Homo sapiens_hsa051320.51239055
106Hepatitis B_Homo sapiens_hsa051610.49171583
107Chemokine signaling pathway_Homo sapiens_hsa040620.48788710
108T cell receptor signaling pathway_Homo sapiens_hsa046600.46561916
109Fatty acid elongation_Homo sapiens_hsa000620.46249821
110N-Glycan biosynthesis_Homo sapiens_hsa005100.45826462
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.44578910
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44460831
113Sphingolipid metabolism_Homo sapiens_hsa006000.42125061
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40127767
115Caffeine metabolism_Homo sapiens_hsa002320.38805602
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37377957
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.37343422
118Vibrio cholerae infection_Homo sapiens_hsa051100.35900732
119Gastric acid secretion_Homo sapiens_hsa049710.34776893
120Retinol metabolism_Homo sapiens_hsa008300.34424274
121Sulfur relay system_Homo sapiens_hsa041220.33802844
122Parkinsons disease_Homo sapiens_hsa050120.31777012
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31600685
124ABC transporters_Homo sapiens_hsa020100.25894862
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23901288
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21602416
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17652945
128* Cyanoamino acid metabolism_Homo sapiens_hsa004600.16697024
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15147853
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14421518
131Choline metabolism in cancer_Homo sapiens_hsa052310.13944131
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13062223
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09272251
134Tyrosine metabolism_Homo sapiens_hsa003500.08329186
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08297177
136Alzheimers disease_Homo sapiens_hsa050100.07856411
137Inositol phosphate metabolism_Homo sapiens_hsa005620.07825609
138Insulin resistance_Homo sapiens_hsa049310.07354649
139* Arachidonic acid metabolism_Homo sapiens_hsa005900.07159333
140Tight junction_Homo sapiens_hsa045300.05578228
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.02437215
142AMPK signaling pathway_Homo sapiens_hsa041520.00917439
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.00392351
144Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0041139
145Hepatitis C_Homo sapiens_hsa05160-0.0040468

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